CN109793687A - A kind of preparation method of the toothpaste for periodontitis - Google Patents
A kind of preparation method of the toothpaste for periodontitis Download PDFInfo
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- CN109793687A CN109793687A CN201910231895.2A CN201910231895A CN109793687A CN 109793687 A CN109793687 A CN 109793687A CN 201910231895 A CN201910231895 A CN 201910231895A CN 109793687 A CN109793687 A CN 109793687A
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Abstract
The present invention relates to daily chemical product fields, the preparation method of especially a kind of toothpaste for periodontitis, it is matched according to following component and parts by weight: sorbierite 30, propylene glycol 10, saccharin sodium 0.5, lauryl sodium sulfate 3.0, silica 22, carmethose 1.0, xanthan gum 0.5, Lotus Leafextract 3, andrographolide 0.5, eugenol 0.7, methylparaben 0.02, Buddhist nun's platinum propyl ester 0.02, essence 1.2, surplus is water, it is prepared using three-in-one Manufacturing medicine extract machine, toothpaste prepared by the present invention can be up to 98.75% to the total effective rate of periodontitis, there is safety for the prevention and treatment of periodontitis, significant curative effect.
Description
Technical field
The present invention relates to daily chemical product field, the preparation method of especially a kind of toothpaste for periodontitis.
Background technique
With advancing age, gum will appear phenomena such as atrophy, tooth mobility, displacement.Also with bleeding, suppurate, tooth
All swelling, chewing pain etc..
Chronic periodontitis is not paid attention to by patient, and clinical manifestation is early stage oral pocket and absorption of alveolar bone, but degree occur
Relatively light, tooth does not loosen still, only gum redness and bleeding when brushing teeth, feeding, and does not often cause the attention of patient.So that alveolar bone
It absorbs seriously, after forming deep oral pocket, tooth mobility, masticatory atonia or pain occurs, acute periodontal abscess etc. can also occur
It just goes to a doctor, but disease has been advanced stage at this time, illness rate obviously increases after 35 years old.
And the main pathogenic of chronic periodontal disease is bacterium, long-run development causes the formation of oral pocket, the suction of alveolar bone
It receives, the loose shift etc. of tooth.Porphyromonas gingivalis is most important dominant bacteria in chronic periodontitis lesion；With unwrapping wire unwrapping wire
Bacterium is the flora of aggressive periodontitis；Fusobacterium nucleatum is on gum and the dominant bacteria at the positions such as subgingival plaque, oral pocket.
So in daily cleaning tooth simultaneously it is necessary to the carry out early prevention of periodontitis and treatment.
Summary of the invention
In order to solve the above technical problems, the invention discloses a kind of preparation methods of toothpaste for periodontitis.
Specific technical solution is as follows:
A kind of preparation method of the toothpaste for periodontitis, is matched according to following component and parts by weight: sorbierite 30,
Propylene glycol 10, saccharin sodium 0.5, lauryl sodium sulfate 3.0, silica 22, carmethose 1.0, xanthan gum 0.5, lotus
Leaf extract 3, andrographolide 0.5, eugenol 0.7, methylparaben 0.02, Buddhist nun's platinum propyl ester 0.02, essence 1.2；
Specific preparation process is as follows:
(1) eugenol, andrographolide are weighed in proportion, are dissolved in essence and are put into essence bucket for use；
(2) lauryl sodium sulfate, silica, carmethose, xanthan gum, Lotus Leafextract are weighed in proportion,
It is put into powder material tank stand-by；
(3) methylparaben, Buddhist nun's platinum propyl ester are weighed in proportion, are dissolved in propylene glycol for use, are weighed mountain is added in proportion
Pears alcohol, propylene glycol, saccharin sodium are placed into water batch can together and stir evenly for use；
(4) vacuum for opening three-in-one Manufacturing medicine extract machine, water batch can in step (3) is pumped into vacuum degree -0.4MP into main cooker
Water material, in vacuum degree -0.85MP, open main cooker inside wall rabbling mechanism of scraping be stirred；Open high speed homogenization dispersion
Wheel disperses the powder in wheel rotation sucking step (2) powder material tank using high speed homogenization；After the sucking of whole powders, in vacuum degree-
Timing when 0.95MP closed vacuum function after 15 minutes, by the essence in essence adding mouth sucking step (1) essence bucket, stirring
Be again turned on vacuum after one minute, continue stirring squeeze out after ten minutes it is filling.
The essence is one or more of fragrant purple perilla, Thymol, eugenol or peppermint oil.
It is whole in whipping process in the step (4) to open ultrasonic wave, carry out ultrasonic emulsification.
Bottom side is equipped with pneumatic hammer inside the powder material tank of the three-in-one Manufacturing medicine extract machine, destroys powder knot wall.
In the main cooker of the three-in-one Manufacturing medicine extract machine it is high-power, scrape wall rabbling mechanism, mixing speed is 65-180 revs/min
The main cooker side of three-in-one Manufacturing medicine extract machine is arranged in the essence adding mouth.
The high speed homogenization dispersion wheel is arranged in three-in-one Manufacturing medicine extract machine inside main cooker, for thoroughly breaking material and powder
Dissipate refinement.
Compared with prior art, the present invention has following advantageous effects:
(1) primary raw material function of the invention is as follows:
Dripping pills of andrographolide is the effective ingredient extracted from Herba Andrographitis, and monomer purity is up to 98% or more, effect etc.
Same Herba Andrographitis.The ingredient of creat lactone dripping pill, Herba Andrographitis are the herb of acanthaceous plant Herba Andrographitis.The annual grass of Herba Andrographitis
This, originates in Southeast Asia.The effect of Herba Andrographitis: bitter, it is cold in nature；Return heart, lung, stomach, bladder meridian；It is inducing diuresis and reducing edema with clearing heat and detoxicating
The effect of；Cure mainly wind-heat cold, warm disease and fever, lung heat cough and asthma, pertussis, pulmonary abscess, abscess of throat, diarrhea due to damp-heat, jaundice, heat
Leaching, blood strangury, eczema, erysipelas, mumps, boil carbuncle swells, burn and scald, venomous snake bite.So dripping pills of andrographolide has heat-clearing solution
The effect of poison, antibacterial anti-inflammatory, while Herba Andrographitis has inhibitory or killing effect to porphyromonas gingivalis.
Lotus Leafextract: containing chalcopyrite cpds in Lotus Leafextract is effective component, red to periodontitis, halitosis, gum
The main pathogenic bacteria of the illnesss such as swollen has to be acted on compared with high inhibition.
Eugenol: for plant clove of myrtaceae dry flower through distilling resulting volatile oil.Warm stomach, warm kidney.It cures mainly
Stomach cold pain swollen, hiccup, vomiting and diarrhoea, numbness pain, colic, halitosis, toothache.Eugenol is to Candida albicans, staphylococcus aureus, chain pearl
Bacterium etc. has inhibiting effect, and a pharmacological action with antiviral, analgesia, surface anesthesia, and safe and non-toxic non-stimulated, can be used for
Thrush and canker sore.Eugenol and andrographolide share, and can promote the bacteriostasis of andrographolide.
(2) present invention uses fragrant purple perillas as essence, is not traditional compound essence, and is derived from pure natural plant
Object is white crystalline powder made of extracting from the stem, leaf of natural perfume purple perilla plant, there is faint amber aroma, spreads
Strong and smell is lasting, can give essence lively harmonious lasting fragrance, and body and mind is loosened in tranquilizing the mind.
(3) present invention uses the three-in-one Manufacturing medicine extract machine of vacuum, and liquid charging stock is pre-dispersed in the completion predissolve of water batch can, by vacuum
Suction system sucks powder in main cooker；For powder in powder material tank, powder material tank bottom side is equipped with pneumatic hammer, destroys powder knot wall phenomenon,
And residual powder in storehouse can be made to be completely introduced into main cooker, guarantee raw material proportioning.Powder is sucked by unit of vacuum material-suction system and is led in powder material tank
In pot.In main cooker it is high-power, scrape wall rabbling mechanism and can guarantee and be sufficiently mixed material.High speed homogenization dispersion is taken turns material and powder
Body thoroughly breaks up refinement；Main cooker side is additionally provided with essence adding mouth, wastes micro flavor of raw material not and is thoroughly mixed into material.Pot
It inside can also increase grinder, keep material finer.Heat produced during the preparation process can lead to cooling water by interlayer reduces temperature
Degree, bubble are discharged outside pot by vacuum defoamation function.The fineness of grind that can guarantee raw material, is uniformly mixed, primary efficacy
Raw material be inside lotion it is evenly dispersed, without dead angle, vacuum defoamation can guarantee when in use with oral cavity, tooth and tongue
Contact fitting is closer, gives full play to drug effect.
Specific embodiment
The present invention is described in detail combined with specific embodiments below, but protection scope of the present invention is not by embodiment institute
Limit.
Three-in-one Manufacturing medicine extract machine used in embodiment is the RH type three of that Witter Administration & Mechanical Development Co., Ltd of Wuxi English production
Unify vacuum Manufacturing medicine extract machine.
Embodiment 1:
A kind of preparation method of the toothpaste for periodontitis, is matched: sorbierite according to following component and parts by weight
30g, propylene glycol 10g, saccharin sodium 0.5g, lauryl sodium sulfate 3.0g, silica 22g, carmethose 1.0g, xanthan
Glue 0.5g, Lotus Leafextract 3g, andrographolide 0.5g, eugenol 0.7g, methylparaben 0.02g, Buddhist nun's platinum propyl ester
0.02g, fragrant purple perilla and the total 1.2g of Thymol；
Specific preparation process is as follows:
(1) eugenol, andrographolide are weighed in proportion, are dissolved in fragrant purple perilla and Thymol is put into essence bucket for use；
(2) lauryl sodium sulfate, silica, carmethose, xanthan gum, Lotus Leafextract are weighed in proportion,
It is put into powder material tank stand-by；
(3) methylparaben, Buddhist nun's platinum propyl ester are weighed in proportion, are dissolved in propylene glycol for use, are weighed mountain is added in proportion
Pears alcohol, propylene glycol, saccharin sodium are placed into water batch can together and stir evenly for use；
(4) vacuum for opening three-in-one Manufacturing medicine extract machine, water batch can in step (3) is pumped into vacuum degree -0.4MP into main cooker
Water material, in vacuum degree -0.85MP, open main cooker inside wall rabbling mechanism of scraping be stirred；Open high speed homogenization dispersion
Wheel disperses the powder in wheel rotation sucking step (2) powder material tank using high speed homogenization；After the sucking of whole powders, in vacuum degree-
Timing when 0.95MP closed vacuum function after 15 minutes, by the essence in essence adding mouth sucking step (1) essence bucket, stirring
Be again turned on vacuum after one minute, continue stirring squeeze out after ten minutes it is filling.
It is whole in whipping process in the step (4) to open ultrasonic wave, carry out ultrasonic emulsification.
Bottom side is equipped with pneumatic hammer inside the powder material tank of the three-in-one Manufacturing medicine extract machine, destroys powder knot wall.
In the main cooker of the three-in-one Manufacturing medicine extract machine it is high-power, scrape wall rabbling mechanism, mixing speed is 65 revs/min
The main cooker side of three-in-one Manufacturing medicine extract machine is arranged in the essence adding mouth.
The high speed homogenization dispersion wheel is arranged in three-in-one Manufacturing medicine extract machine inside main cooker, for thoroughly breaking material and powder
Dissipate refinement.
Embodiment 2:
Difference from Example 1 is that the essence is eugenol and peppermint oil.
Embodiment 3:
Difference from Example 1 is that the essence is peppermint oil.
Carrying out microorganism detection to toothpaste prepared by embodiment 1, the results are shown in Table 1:
1 microorganism detection result of table
| Detection project | Testing result | Standard value |
| Total number of bacterial colonies (CFU/g) | <20 | ≤200 |
| Fungus colony sum (CFU/g) | <20 | ≤100 |
| Escherichia coli | It is not detected | It must not detect |
| Staphylococcus aureus | It is not detected | It must not detect |
| Hemolytic streptococcus | It is not detected | It must not detect |
| Pseudomonas aeruginosa | It is not detected | It must not detect |
160 patients with periodontitis are chosen, toothpaste three months prepared using the embodiment of the present invention 1 are being used 5 days respectively
Afterwards, the effect after 6-15 days and 16-20 days is counted, and the results are shown in Table 2:
2 160 patients with periodontitis using effects of table
It can be seen that toothpaste prepared by the present invention to periodontitis according to the using effect investigation result to 160 experimenters
Total effective rate can be up to 98.75%, have safety, significant curative effect for the prevention and treatment of periodontitis.
Claims (7)
1. a kind of preparation method of the toothpaste for periodontitis, it is characterised in that: matched according to following component and parts by weight:
Sorbierite 30, propylene glycol 10, saccharin sodium 0.5, lauryl sodium sulfate 3.0, silica 22, carmethose 1.0, xanthan
Glue 0.5, Lotus Leafextract 3, andrographolide 0.5, eugenol 0.7, methylparaben 0.02, Buddhist nun's platinum propyl ester 0.02, essence
1.2；
Specific preparation process is as follows:
(1) eugenol, andrographolide are weighed in proportion, are dissolved in essence and are put into essence bucket for use；
(2) lauryl sodium sulfate, silica, carmethose, xanthan gum, Lotus Leafextract are weighed in proportion, are put into
It is stand-by in powder material tank；
(3) methylparaben, Buddhist nun's platinum propyl ester are weighed in proportion, be dissolved in propylene glycol it is stand-by, weigh in proportion be added sorbierite,
Propylene glycol, saccharin sodium are placed into water batch can together and stir evenly for use；
(4) vacuum for opening three-in-one Manufacturing medicine extract machine, the water of water batch can in step (3) is pumped into vacuum degree -0.4MP into main cooker
Material is opened the wall rabbling mechanism of scraping inside main cooker and is stirred in vacuum degree -0.85MP；Open high speed homogenization dispersion wheel, benefit
Disperse the powder in wheel rotation sucking step (2) powder material tank with high speed homogenization；After the sucking of whole powders, in vacuum degree-
Timing when 0.95MP closed vacuum function after 15 minutes, by the essence in essence adding mouth sucking step (1) essence bucket, stirring
Be again turned on vacuum after one minute, continue stirring squeeze out after ten minutes it is filling.
2. the preparation method of the toothpaste according to claim 1 for periodontitis, it is characterised in that: the essence is fragrant purple
One or more of Soviet Union, Thymol, eugenol or peppermint oil.
3. the preparation method of the toothpaste according to claim 1 for periodontitis, it is characterised in that: in the step (4)
It is whole in whipping process to open ultrasonic wave, carry out ultrasonic emulsification.
4. the preparation method of the toothpaste according to claim 1 for periodontitis, it is characterised in that: the three-in-one cream processed
Bottom side is equipped with pneumatic hammer inside the powder material tank of machine, destroys powder knot wall.
5. the preparation method of the toothpaste according to claim 1 for periodontitis, it is characterised in that: the three-in-one cream processed
In the main cooker of machine it is high-power, scrape wall rabbling mechanism, mixing speed is 65-180 revs/min.
6. the preparation method of the toothpaste according to claim 1 for periodontitis, it is characterised in that: the essence adding mouth
The main cooker side of three-in-one Manufacturing medicine extract machine is set.
7. the preparation method of the toothpaste according to claim 1 for periodontitis, it is characterised in that: the high speed homogenization point
It dissipates wheel to be arranged in three-in-one Manufacturing medicine extract machine inside main cooker, for material and powder thoroughly to be broken up refinement.
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| CN201910231895.2A CN109793687A (en) | 2019-03-26 | 2019-03-26 | A kind of preparation method of the toothpaste for periodontitis |
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| CN201910231895.2A CN109793687A (en) | 2019-03-26 | 2019-03-26 | A kind of preparation method of the toothpaste for periodontitis |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1345599A (en) * | 2000-09-28 | 2002-04-24 | 国家医药管理局上海医药工业研究院 | Oral cavity bacteriostatic composition containing extract of Chinese herb lotus leaf |
| US20060264497A1 (en) * | 2005-03-28 | 2006-11-23 | Zeligs Michael A | Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health |
| CN102895147A (en) * | 2012-09-25 | 2013-01-30 | 广州中汉口腔用品有限公司 | Toothpaste with anti-inflammation and anti-allergic effects and making technology thereof |
| CN109223663A (en) * | 2018-11-23 | 2019-01-18 | 丹东康齿灵牙膏有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis |
-
2019
- 2019-03-26 CN CN201910231895.2A patent/CN109793687A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1345599A (en) * | 2000-09-28 | 2002-04-24 | 国家医药管理局上海医药工业研究院 | Oral cavity bacteriostatic composition containing extract of Chinese herb lotus leaf |
| US20060264497A1 (en) * | 2005-03-28 | 2006-11-23 | Zeligs Michael A | Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health |
| CN102895147A (en) * | 2012-09-25 | 2013-01-30 | 广州中汉口腔用品有限公司 | Toothpaste with anti-inflammation and anti-allergic effects and making technology thereof |
| CN109223663A (en) * | 2018-11-23 | 2019-01-18 | 丹东康齿灵牙膏有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis |
Non-Patent Citations (1)
| Title |
|---|
| 谢明勇 等: "《日用化学品实用生产技术与配方》", 30 June 2002, 江西科学技术出版社 * |
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Application publication date: 20190524 |
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