CN109771484A - A kind of antibacterial anti hemorrhagic plaster and preparation method thereof - Google Patents
A kind of antibacterial anti hemorrhagic plaster and preparation method thereof Download PDFInfo
- Publication number
- CN109771484A CN109771484A CN201910165496.0A CN201910165496A CN109771484A CN 109771484 A CN109771484 A CN 109771484A CN 201910165496 A CN201910165496 A CN 201910165496A CN 109771484 A CN109771484 A CN 109771484A
- Authority
- CN
- China
- Prior art keywords
- parts
- plaster
- antibacterial anti
- anti hemorrhagic
- tanguticum maxim
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of antibacterial anti hemorrhagic plaster and preparation method thereof, belong to pharmaceutical technology field, including the bulk pharmaceutical chemicals by following weight parts: 20 ~ 30 parts of styrax, 60 ~ 80 parts of Rheum tanguticum Maxim, 20 ~ 40 parts of common embelia fruit, 50 ~ 80 parts of falcate crazyweed herb, 400~600 parts of sesame oil, 60~80 parts of vaseline, 100~120 parts of beeswax.The invention also discloses a kind of preparation methods of antibacterial anti hemorrhagic plaster.The present invention is according to Tibetan medicine medication basic principle and modern pharmacology result, antibacterial anti hemorrhagic composition meets antibacterial anti hemorrhagic formula in Tibetan medicine and pharmacology, again using the application targeting of active site and the high efficiency of drug effect in each taste medicine in these compositions, it is prepared for low dose of, high activity antibacterial anti hemorrhagic plaster in sequence.
Description
Technical field
The invention belongs to pharmaceutical technology field, it is related to a kind of antibacterial anti hemorrhagic plaster and preparation method thereof.
Background technique
It is all to prevent the drug to be acted on based on internal external hemorrhage, claim hemostatic.It acts on as follows with indication:
1. cooling blood and hemostasis: the various bleedings of blood-heat bleeding；
2. astringing to arrest bleeding: how puckery pharmacological property is, with it is various go out blood trouble (except stagnation of blood stasis goes out blood trouble)；
3. removing blood stasis and hemostasis: stagnation of blood stasis goes out blood trouble symptoms include color is purple dark, or has stasis of blood block, and not with local pain, sore spot
The diseases such as shifting；
4. warming channel for arresting bleeding: deficient cold type bleeding.Symptoms include how light color is, sallow complexion, pale tongue, out of strength, aversion to cold and cold limbs, arteries and veins are thin or
Late.
Blood trouble out: such as hemoptysis, hemoptysis, bleeding from five sense organs or subcutaneous tissue, haematemesis, hematochezia, hematuria, metrorrhagia and metrostaxis, purpura and traumatic hemorrhage.
Modern pharmacological research proves that most haemostatic medicaments are respectively provided with local vasoconstriction, shortens the clotting time；Improve blood
Tube wall function increases capillary to the resistance of damage；Vasopermeability is reduced, activity of fibrinolysin etc. is inhibited to make
With.Its mechanism of action mainly passes through reinforcement intravascular coagulation factor or inhibits anticoagulant factor, to promote the blood of bleeding part solidifying
Gu and reaching hemostasis purpose.Some drugs also can increase blood platelet.Individual drugs are respectively provided with coronary artery dilator, increase hat
Shape blood flow volume reduces the effect of myocardial oxygen consumption；Or antimalarial, antitumaous effect；Or cough-relieving, the effects of relievining asthma.
In currently available technology, there are no a kind of short treating periods, the antibacterial anti hemorrhagic drug of Small side effects and preparation method thereof.
Summary of the invention
The purpose of the present invention is to provide a kind of short treating periods, the antibacterial anti hemorrhagic plaster of Small side effects and preparation method thereof.
Itself the specific technical proposal is:
A kind of antibacterial anti hemorrhagic plaster, including the bulk pharmaceutical chemicals by following weight parts: 20~30 parts of styrax, Rheum tanguticum Maxim 60
~80 parts, 20~40 parts of common embelia fruit, 50~80 parts of falcate crazyweed herb, 400~600 parts of sesame oil, 60~80 parts of vaseline, beeswax 100
~120 parts.
Preferably, including the bulk pharmaceutical chemicals by following weight parts: 25 parts of styrax, 78 parts of Rheum tanguticum Maxim, 30 parts of common embelia fruit,
72 parts of falcate crazyweed herb, 558 parts of sesame oil, 70 parts of vaseline, 100 parts of beeswax.
Rheum tanguticum Maxim (Rh.tanguticum Maxim.ex Balf.) distribution is wide, and the sedimentation of taste bitter cold is usually used in controlling
Haematemesis, bleeding from five sense organs or subcutaneous tissue caused by blood-heat bleeding are treated, is mostly applied in compound, it can also using single rheum officinale.Also have extensive antibacterium,
The effects of antimycotic, antiviral, antiprotozoan.Effective bacteriostatic ingredients are free aglycons, wherein big with Rhein, rheum emodin and aloe
Flavine antibacterial action is most strong.Rheum emodin shows pseudomonas aeruginosa, methicillin-resistant staphylococcus aureus significant anti-
Bacterium activity, rheum emodin can also inhibit the growth of helicobacter pylori, have to the treatment of Helicobacter pylori gastric ulcer important
Meaning can obviously reduce recurrence rate.The external infected by influenza of rheum officinale, herpes simplex virus, hepatitis B, Coxsackie virus have
Different degrees of inhibiting effect.Rheum emodin is to hepatitis B, cytomegalovirus, Epstein-Barr virus, coronavirus, poliovirus
There is inhibiting effect, there is effect of killing the virus to a certain extent.
Oxytropis falcate Bunge (Oxytropis falcata Bunge), also known as " cowherb reaches the summer ", are pulse family Genus Oxytropis Dc
The perennial acaulescence herbaceous plant of (Oxytropis D.C.), with all herbal medicine.Its main product is in China Tibet, Qinghai, Gan Sunan
The high altitude localities on the ground such as portion, western Sichuan, it is resourceful.It is falcate crazyweed herb acrid flavour, cold in nature, enter lung, spleen two passes through, enjoys " herbal medicine
King " reputation.Falcate crazyweed herb is often used to treatment plague, leprosy, flu, hematochezia, bone fracture, knife wound etc. in Tibetan medicine, passes through medicine
Reason experiment discovery, falcate crazyweed herb general flavone and volatile-oil composite percutaneous dosing have good anti-inflammatory and antalgic activity, wherein always
Flavone aglycone has stronger bacteriostasis to 9 kinds of pathogens；2' in falcate crazyweed herb, 4'- dihydroxy chalcone have shortening small
The mouse bleeding time accelerates blood coagulation and shortens the effect of prothrombin time.
Common embelia fruit is the dry mature fruit of Myrsinacea plant Embelia laeta [Embelia laeta (L.) Mez], also known as sour
Jiang, sour rattan head, embelin, salty tart fruit, it is sweet in flavor, sour, it is mild-natured, there is astringing to arrest bleeding, can be used for the deficiency of blood, gingiva bleeding gingival hemorrhage etc.
Disease.Common embelia fruit is also Tibetan conventional crude drugs, and Tibetan medicine name " Qi Dangga ", Tibetan is used as medicine after mostly being dried with its mellow fruit, modern
Pharmaceutical research shows that Embelia laeta has the pharmacotoxicological effects such as antitumor, antibacterial.
Styrax is the dry of Styracaceae plant styrax tonkinensis Craib ex Hart Styraxtonkinensis (Pierre) Craib ex Hart.
Dry resin, nature and flavor be it is pungent, bitter, put down, have effects that inducing resuscitation of having one's ideas straightened out, the promoting flow of qi and blood circulation, analgesic.
Anti-inflammatory, the hemostasis in certain polar solvent extraction Rheum tanguticum Maxim, falcate crazyweed herb and common embelia fruit are utilized in the present invention
After active constituent, active constituent is purified by anion exchange resin, to improve antibacterial anti hemorrhagic drug effect.In the preparation of plaster
Process first carries out phenolic glycoside constituents, common embelia fruit that Rheum tanguticum Maxim and falcate crazyweed herb are successively mixed into after the suitable refining of plaster substrate
Flavones ingredient and benzoin resin, thus not only increase gained plaster in antibacterial anti hemorrhagic effect, but also have analgesic
And stimulating effect.
The present invention is according to Tibetan medicine medication basic principle and modern pharmacology as a result, antibacterial anti hemorrhagic composition meets in Tibetan medicine and pharmacology
Antibacterial anti hemorrhagic formula, and using the application targeting of active site and the high efficiency of drug effect in each taste medicine in these compositions, it presses
Certain sequence is prepared for low dose of, high activity antibacterial anti hemorrhagic plaster.According to Literature Consult, in disclosed patent not in
The identical composition of this plaster and preparation method.
A kind of preparation method of antibacterial anti hemorrhagic plaster of the present invention, comprising the following steps:
(1) each bulk pharmaceutical chemicals are weighed according to parts by weight of the present invention；
(2) Rheum tanguticum Maxim and falcate crazyweed herb are crushed, cross 80 meshes, mixed, 15~30 times of 30% ethyl alcohol of amount is added to impregnate 8
~12 hours；
(3) filtered again in 40-60 DEG C of heating and refluxing extraction 1h, the dregs of a decoction also extract twice in same condition, filter, and merge
3 filtrates, concentration, obtain Rheum tanguticum Maxim and falcate crazyweed herb concentrate；
(4) by Rheum tanguticum Maxim and falcate crazyweed herb concentrate 4%NaOH tune pH=9~11, on the yin handled well from
Sub-exchange resin column distills washing anion-exchange resin column with 6BV~8BV；
(5) after eluting anion-exchange resin column with the 2mol/L hydrochloric acid of 2BV~3BV again, and with the 70% of 10BV~12BV
Ethanol eluate is concentrated under reduced pressure in the parsing of~95% ethyl alcohol, dry, grinding, obtains the phenolic glycoside member of Rheum tanguticum Maxim and falcate crazyweed herb
Position powder；
(6) by dry common embelia fruit, crush, cross 80 meshes, mix, 15~30 times of 60~80% ethyl alcohol of amount is added to impregnate 1~2
Hour after, 40-60 DEG C of heating and refluxing extraction three times, each 1h, filtering, merge filtrate three times, be concentrated, obtain common embelia fruit concentration
Liquid；
(7) take pure free from admixture sesame oil to be put into pot, add beeswax, vaseline, be heated to 200 DEG C, put and temper 1-2 on stove fire
Hour；
(8) the oil that will have been tempered is cooled to 80 DEG C from fire, slowly by the phenolic glycoside class position of Rheum tanguticum Maxim and honest and clean shape whin
Powder is put into the plaster oil refined, and stirring when temperature is down to 40 DEG C, is added after styrax is dissolved, and is stirred, is added
Common embelia fruit concentrate is again stirring for get antibacterial anti hemorrhagic plaster.
Further, the step (4) in by Rheum tanguticum Maxim and falcate crazyweed herb concentrate 4%NaOH tune pH=9~11.
Further, the step (5) in 2BV~3BV 2mol/L hydrochloric acid elution anion-exchange resin column after, with
70%~95% ethyl alcohol of 10BV~12BV parses；
Further, the step (7) in the oil that will have been tempered, 80 DEG C are cooled to from fire, slowly by Rheum tanguticum Maxim and sickle
The phenolic glycoside class position powder of shape whin is put into the plaster oil refined, stirring, and when temperature is down to 40 DEG C, it is molten that styrax is added
Xie Hou, stirring, is eventually adding common embelia fruit and is again stirring for.
Compared with prior art, the invention has the benefit that
1, Rheum tanguticum Maxim has the effects that extensive antibacterium, antimycotic, antiviral, antiprotozoan, and external convection current is susceptible
Poison, herpes simplex virus, hepatitis B, Coxsackie virus have different degrees of inhibiting effect, and effective bacteriostatic ingredients are trips
From phenolic glycoside class aglycon；Falcate crazyweed herb is often used to treatment plague, leprosy, flu, hematochezia, bone fracture, knife wound etc. in Tibetan medicine, passes through
Pharmacological evaluation finds that the phenolic glycoside class aglycon in falcate crazyweed herb has stronger bacteriostasis to 9 kinds of pathogens.For this purpose, in the present invention
Using the similar principle that mixes, it is extracted in Rheum tanguticum Maxim and falcate crazyweed herb after glycoside, it is both real on anion-exchange resin column
Glycoside degradation is showed, and aglycon is made to achieve the effect that separation.This method not only solves active constituent in different medicinal materials and extracts
It is the problems such as process operating procedure is more, the period is long caused by two mutually independent processes, and also ensures obtained
Active site yield is high, purity is high, so that it is in the production of drug, research and clinically has a higher application value.
2, the antibacterial anti hemorrhagic plaster and preparation method thereof that the present invention obtains is to have relatively strong antibacterial and antibacterial effect hiding
The active phenolic glycoside of medicine Rheum tanguticum Maxim and falcate crazyweed herb member, common embelia fruit and inducing resuscitation of having one's ideas straightened out, analgesic, antiulcer with astringing to arrest bleeding
The styrax of effect.This not only enables gained plaster efficient in antibacterial anti hemorrhagic effect, but also has analgesic and stimulating effect.
3, the solvent that operation of the present invention process uses is ethyl alcohol, safety.
4, it is directed to active site, using suitable polarity solvent, realization is efficiently separated and prepared, to improve plaster application
Targeting and drug effect high efficiency.
Specific embodiment
Technical solution of the present invention is described in more detail combined with specific embodiments below.
A kind of antibacterial anti hemorrhagic plaster of embodiment 1 and preparation method thereof, comprising the following steps:
(1) a kind of composition of antibacterial anti hemorrhagic plaster are as follows: styrax 20g, Rheum tanguticum Maxim 60g, common embelia fruit 20g, crescent spine
Beans 50g, sesame oil 400g, vaseline 70g, beeswax 100g；
(2) Rheum tanguticum Maxim and falcate crazyweed herb are crushed, cross 80 meshes, mixed, 15 times of 30% ethyl alcohol of amount is added to impregnate 8 hours；
(3) filtered again in 40 DEG C of heating and refluxing extraction 1h, the dregs of a decoction also extract twice in same condition, and filtering merges 3 times
Filtrate, concentration, obtains Rheum tanguticum Maxim and falcate crazyweed herb concentrate；
(4) by Rheum tanguticum Maxim and falcate crazyweed herb concentrate 4%NaOH tune pH=9, on the anion handled well hand over
Resin column is changed, distills washing anion-exchange resin column with 6BV；
(5) after eluting anion-exchange resin column with the 2mol/L hydrochloric acid of 2BV again, and with the parsing of 70% ethyl alcohol of 10BV, subtract
Pressure concentration ethanol eluate, dry, grinding obtains the phenolic glycoside class position powder of Rheum tanguticum Maxim and falcate crazyweed herb；
(6) by dry common embelia fruit, crush, cross 80 meshes, mix, after adding 15 times of 60 ethyl alcohol of amount to impregnate 1 hour, at 40 DEG C
Three times, each 1h, filtering merges filtrate three times to heating and refluxing extraction, is concentrated, obtains common embelia fruit concentrate；
(7) take pure free from admixture sesame oil to be put into pot, add beeswax, vaseline, be heated to 200 DEG C, put and temper 1.5 on stove fire
Hour；
(8) the oil that will have been tempered is cooled to 80 DEG C from fire, slowly by the phenolic glycoside class position of Rheum tanguticum Maxim and honest and clean shape whin
Powder is put into the plaster oil refined, and stirring when temperature is down to 40 DEG C, is added after styrax is dissolved, and is stirred, is added
Common embelia fruit concentrate and stirring to get antibacterial anti hemorrhagic plaster.
A kind of antibacterial anti hemorrhagic plaster of embodiment 2 and preparation method thereof, comprising the following steps:
(1) a kind of composition of antibacterial anti hemorrhagic plaster are as follows: styrax 25g, Rheum tanguticum Maxim 78g, common embelia fruit 30g, crescent spine
Beans 72g, sesame oil 558g, vaseline 70g, beeswax 100g；
(2) Rheum tanguticum Maxim and falcate crazyweed herb are crushed, cross 80 meshes, mixed, 20 times of 30% ethyl alcohol of amount is added to impregnate 9 hours；
(3) filtered again in 50 DEG C of heating and refluxing extraction 1h, the dregs of a decoction also extract twice in same condition, and filtering merges 3 times
Filtrate, concentration, obtains Rheum tanguticum Maxim and falcate crazyweed herb concentrate；
(4) by Rheum tanguticum Maxim and falcate crazyweed herb concentrate 4%NaOH tune pH=9, on the anion handled well hand over
Resin column is changed, distills washing anion-exchange resin column with 6BV；
(5) after eluting anion-exchange resin column with the 2mol/L hydrochloric acid of 2BV again, and with the parsing of 80% ethyl alcohol of 10BV, subtract
Pressure concentration ethanol eluate, dry, grinding obtains the phenolic glycoside member position powder of Rheum tanguticum Maxim and falcate crazyweed herb；
(6) by dry common embelia fruit, crush, cross 80 meshes, mix, after adding 20 times of 65% ethyl alcohol of amount to impregnate 1 hour, 50
Three times, each 1h, filtering merges filtrate three times for DEG C heating and refluxing extraction, is concentrated, obtains common embelia fruit concentrate；
(7) take pure free from admixture sesame oil to be put into pot, add beeswax, vaseline is heated to 200 DEG C, puts and temper 1.5 on stove fire
Hour；
(8) the oil that will have been tempered is cooled to 80 DEG C from fire, slowly by the phenolic glycoside class position of Rheum tanguticum Maxim and honest and clean shape whin
Powder is put into the plaster oil refined, and stirring when temperature is down to 40 DEG C, is added after styrax is dissolved, and is stirred, is added
Common embelia fruit concentrate is again stirring for get antibacterial anti hemorrhagic plaster.
A kind of antibacterial anti hemorrhagic plaster of embodiment 3 and preparation method thereof, comprising the following steps:
(1) a kind of composition of antibacterial anti hemorrhagic plaster are as follows: styrax 25g, Rheum tanguticum Maxim 70g, common embelia fruit 30g, crescent spine
Beans 65g, sesame oil 550g, vaseline 70g, beeswax 110g；
(2) Rheum tanguticum Maxim and falcate crazyweed herb are crushed, cross 80 meshes, mixed, add 25 times of 30% ethyl alcohol of amount to impregnate 10 small
When；
(3) filtered again in 55 DEG C of heating and refluxing extraction 1h, the dregs of a decoction also extract twice in same condition, and filtering merges 3 times
Filtrate, concentration, obtains Rheum tanguticum Maxim and falcate crazyweed herb concentrate；
(4) by Rheum tanguticum Maxim and falcate crazyweed herb concentrate 4%NaOH tune pH=10, on the anion handled well
Exchange resin column distills washing anion-exchange resin column with 7BV；
(5) after eluting anion-exchange resin column with the 2mol/L hydrochloric acid of 3BV again, and with the parsing of 85% ethyl alcohol of 11BV, subtract
Pressure concentration ethanol eluate, dry, grinding obtains the phenolic glycoside member position powder of Rheum tanguticum Maxim and falcate crazyweed herb；
(6) by dry common embelia fruit, crush, cross 80 meshes, mix, after adding 25 times of 80% ethyl alcohol of amount to impregnate 1.5 hours,
Three times, each 1h, filtering merges filtrate three times to 55 DEG C of heating and refluxing extractions, is concentrated, obtains common embelia fruit concentrate；
(7) take pure free from admixture sesame oil to be put into pot, add beeswax, vaseline, be heated to 200 DEG C, put and temper 1.5 on stove fire
Hour；
(8) the oil that will have been tempered is cooled to 80 DEG C from fire, slowly by the phenolic glycoside class position of Rheum tanguticum Maxim and honest and clean shape whin
Powder is put into the plaster oil refined, and stirring when temperature is down to 40 DEG C, is added after styrax is dissolved, and is stirred, is added
Common embelia fruit concentrate is again stirring for get antibacterial anti hemorrhagic plaster.
A kind of antibacterial anti hemorrhagic plaster of embodiment 4 and preparation method thereof, comprising the following steps:
(1) a kind of composition of antibacterial anti hemorrhagic plaster are as follows: styrax 28g, Rheum tanguticum Maxim 75g, common embelia fruit 35g, crescent spine
Beans 75g, sesame oil 600g, vaseline 70g, beeswax 110g；
(2) Rheum tanguticum Maxim and falcate crazyweed herb are crushed, cross 80 meshes, mixed, add 30 times of 30% ethyl alcohol of amount to impregnate 11 small
When；
(3) filtered again in 55 DEG C of heating and refluxing extraction 1h, the dregs of a decoction also extract twice in same condition, and filtering merges 3 times
Filtrate, concentration, obtains Rheum tanguticum Maxim and falcate crazyweed herb concentrate；
(4) by Rheum tanguticum Maxim and falcate crazyweed herb concentrate 4%NaOH tune pH=10, on the anion handled well
Exchange resin column distills washing anion-exchange resin column with 7BV；
(5) after eluting anion-exchange resin column with the 2mol/L hydrochloric acid of 3BV again, and with the parsing of 85% ethyl alcohol of 12BV, subtract
Pressure concentration ethanol eluate, dry, grinding obtains the phenolic glycoside member position powder of Rheum tanguticum Maxim and falcate crazyweed herb；
(6) by dry common embelia fruit, crush, cross 80 meshes, mix, after adding 25 times of 75% ethyl alcohol of amount to impregnate 2 hours, 60
Three times, each 1h, filtering merges filtrate three times for DEG C heating and refluxing extraction, is concentrated, obtains common embelia fruit concentrate；
(7) take pure free from admixture sesame oil to be put into pot, add beeswax, vaseline, be heated to 200 DEG C, put that temper 2 on stove fire small
When；
(8) the oil that will have been tempered is cooled to 80 DEG C from fire, slowly by the anthraquinone position powder of Rheum tanguticum Maxim and honest and clean shape whin
End is put into the plaster oil refined, and stirring when temperature is down to 40 DEG C, is added after styrax is dissolved, and is stirred, is added acid
Rattan fruit concentrate is again stirring for get antibacterial anti hemorrhagic plaster.
A kind of antibacterial anti hemorrhagic plaster of embodiment 5 and preparation method thereof, comprising the following steps:
(1) a kind of composition of antibacterial anti hemorrhagic plaster are as follows: styrax 30g, Rheum tanguticum Maxim 80g, common embelia fruit 40g, crescent spine
Beans 80g, sesame oil 600g, vaseline 80g, beeswax 120g；
(2) Rheum tanguticum Maxim and falcate crazyweed herb are crushed, cross 80 meshes, mixed, add 30 times of 30% ethyl alcohol of amount to impregnate 12 small
When；
(3) filtered again in 60 DEG C of heating and refluxing extraction 1h, the dregs of a decoction also extract twice in same condition, and filtering merges 3 times
Filtrate, concentration, obtains Rheum tanguticum Maxim and falcate crazyweed herb concentrate；
(4) by Rheum tanguticum Maxim and falcate crazyweed herb concentrate 4%NaOH tune pH=11, on the anion handled well
Exchange resin column distills washing anion-exchange resin column with 8BV；
(5) after eluting anion-exchange resin column with the 2mol/L hydrochloric acid of 3BV again, and with the parsing of 95% ethyl alcohol of 12BV, subtract
Pressure concentration ethanol eluate, dry, grinding obtains the phenolic glycoside member position powder of Rheum tanguticum Maxim and falcate crazyweed herb；
(6) by dry common embelia fruit, crush, cross 80 meshes, mix, after adding 30 times of 80% ethyl alcohol of amount to impregnate 2 hours, 60
Three times, each 1h, filtering merges filtrate three times for DEG C heating and refluxing extraction, is concentrated, obtains common embelia fruit concentrate；
(7) take pure free from admixture sesame oil to be put into pot, add beeswax and vaseline, be heated to 200 DEG C, put that temper 2 on stove fire small
When；
(8) the oil that will have been tempered is cooled to 80 DEG C from fire, slowly by the phenolic glycoside class position of Rheum tanguticum Maxim and honest and clean shape whin
Powder is put into the plaster oil refined, and stirring when temperature is down to 40 DEG C, is added after styrax is dissolved, and is stirred, is added
Common embelia fruit concentrate and stirring to get antibacterial anti hemorrhagic plaster.
The foregoing is only a preferred embodiment of the present invention, the scope of protection of the present invention is not limited to this, it is any ripe
Know those skilled in the art within the technical scope of the present disclosure, the letter for the technical solution that can be become apparent to
Altered or equivalence replacement are fallen within the protection scope of the present invention.
Claims (6)
1. a kind of antibacterial anti hemorrhagic plaster, which is characterized in that including the bulk pharmaceutical chemicals by following weight parts: 20~30 parts of styrax, Tang
Ancient especially big yellow 60~80 parts, 20~40 parts of common embelia fruit, 50~80 parts of falcate crazyweed herb, 400~600 parts of sesame oil, vaseline 60~80
Part, 100~120 parts of beeswax.
2. antibacterial anti hemorrhagic plaster according to claim 1, which is characterized in that including the bulk pharmaceutical chemicals by following weight parts: peace
Cease fragrant 25 parts, 78 parts of Rheum tanguticum Maxim, 30 parts of common embelia fruit, 72 parts of falcate crazyweed herb, 558 parts of sesame oil, 70 parts of vaseline, beeswax 100
Part.
3. the preparation method of antibacterial anti hemorrhagic plaster described in a kind of claim 1, which comprises the following steps:
(1) each bulk pharmaceutical chemicals are weighed according to parts by weight described in claim 1；
(2) Rheum tanguticum Maxim and falcate crazyweed herb are crushed, cross 80 meshes, mixed, 15~30 times of 30% ethyl alcohol of amount is added to impregnate 8~12
Hour；
(3) filtered again in 40-60 DEG C of heating and refluxing extraction 1h, the dregs of a decoction also extract twice in same condition, and filtering merges 3 times
Filtrate, concentration, obtains Rheum tanguticum Maxim and falcate crazyweed herb concentrate；
(4) by Rheum tanguticum Maxim and falcate crazyweed herb concentrate 4%NaOH tune pH=9~11, on the anion handled well hand over
Resin column is changed, distills washing anion-exchange resin column with 6BV~8BV；
(5) again with after the 2mol/L hydrochloric acid of 2BV~3BV elution anion-exchange resin column, and with the 70% of 10BV~12BV~
Ethanol eluate is concentrated under reduced pressure in the parsing of 95% ethyl alcohol, dry, and grinding obtains the phenolic glycoside member portion of Rheum tanguticum Maxim and falcate crazyweed herb
Position powder；
(6) by dry common embelia fruit, crush, cross 80 meshes, mix, 15~30 times of 60~80% ethyl alcohol of amount is added to impregnate 1~2 hour
Afterwards, 40-60 DEG C of heating and refluxing extraction three times, each 1h, filtering, merge filtrate three times, be concentrated, obtain common embelia fruit concentrate；
(7) take pure free from admixture sesame oil to be put into pot, add beeswax, vaseline, be heated to 200 DEG C, put and tempered on stove fire 1-2 hours；
(8) the oil that will have been tempered is cooled to 80 DEG C from fire, slowly by the phenolic glycoside class position powder of Rheum tanguticum Maxim and honest and clean shape whin
It is put into the plaster oil refined, stirring when temperature is down to 40 DEG C, is added after styrax is dissolved, and stirs, adds sour rattan
Fruit concentrate is again stirring for get antibacterial anti hemorrhagic plaster.
4. the preparation method of antibacterial anti hemorrhagic plaster according to claim 3, which is characterized in that the step (4) in by Tang Gute
Rheum officinale and falcate crazyweed herb concentrate 4%NaOH tune pH=9~11.
5. the preparation method of antibacterial anti hemorrhagic plaster according to claim 3, which is characterized in that the step (5) in use 2BV
After~3BV 2mol/L hydrochloric acid elutes anion-exchange resin column, parsed with 70%~95% ethyl alcohol of 10BV~12BV.
6. the preparation method of antibacterial anti hemorrhagic plaster according to claim 3, which is characterized in that the step (7) in will temper
Good oil, be cooled to 80 DEG C from fire, is slowly put into the phenolic glycoside class position powder of Rheum tanguticum Maxim and falcate crazyweed herb and has refined
In plaster oil, stirring, when temperature is down to 40 DEG C, after styrax dissolution is added, stirring is eventually adding common embelia fruit and is again stirring for.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910165496.0A CN109771484A (en) | 2019-03-05 | 2019-03-05 | A kind of antibacterial anti hemorrhagic plaster and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910165496.0A CN109771484A (en) | 2019-03-05 | 2019-03-05 | A kind of antibacterial anti hemorrhagic plaster and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109771484A true CN109771484A (en) | 2019-05-21 |
Family
ID=66486109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910165496.0A Pending CN109771484A (en) | 2019-03-05 | 2019-03-05 | A kind of antibacterial anti hemorrhagic plaster and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109771484A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129488A (en) * | 2007-09-14 | 2008-02-27 | 张建林 | Traditional Chinese medicine ointment for treating burn, scald and method of producing the same |
-
2019
- 2019-03-05 CN CN201910165496.0A patent/CN109771484A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129488A (en) * | 2007-09-14 | 2008-02-27 | 张建林 | Traditional Chinese medicine ointment for treating burn, scald and method of producing the same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2015018129A1 (en) | Antihypertensive chinese medicine preparation and preparation method therefor | |
| CN110693997A (en) | Preparation for removing putrefaction and promoting granulation of scald and burn and preparation method thereof | |
| CN107582899B (en) | Mongolian medicine for clearing heat and stopping bleeding and its preparing process | |
| CN109771484A (en) | A kind of antibacterial anti hemorrhagic plaster and preparation method thereof | |
| CN103989813A (en) | Traditional Chinese medicinal anesthetic for dental operations and preparation method thereof | |
| CN108096318B (en) | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method and application thereof | |
| CN103977266B (en) | Dendrobium officinale traditional Chinese medicine composition for hemostasis | |
| CN106421424A (en) | Anticancer traditional Chinese medicine electuary and preparation method thereof | |
| CN111939238A (en) | A Chinese medicinal composition for resisting virus, preventing infection and preventing epidemic, and its preparation method | |
| CN100496583C (en) | Volatile clove oil and its process for producing medicine composition | |
| CN108743800A (en) | A kind of traditional Chinese medicine powder for treating cardiovascular and cerebrovascular | |
| CN105213871A (en) | A kind of emergency department bactericidal haemostatic Chinese medicine preparation | |
| Tiwari | Phytochemical analysis and medicinal value of Kalmegh (Andrographis paniculata Nees) | |
| KR20020052639A (en) | Process for preparing ginseng extracts | |
| CN109512901A (en) | Radix Wikstroemae extract and its preparing the application in antalgic and inflammation relieving drug | |
| JP2006257018A (en) | Antiobestic agent, medicine and beverage or food | |
| CN107233486A (en) | It is a kind of to treat old salt lemon composition of pharyngitis and preparation method thereof | |
| CN114159536B (en) | Pharmaceutical composition, preparation method and application thereof | |
| CN103565707A (en) | Antiviral traditional Chinese medicine bath gel | |
| CN100459997C (en) | Composition of bitter tea and rhubarb horsetails and preparation method thereof | |
| RO132471A2 (en) | Natural phytotherapeutic product for affections of urinary bladder and reno-urinary tract and process for preparing the same | |
| CN104173747A (en) | Hemostatic anti-inflammation nursing agent and preparation method thereof | |
| CN115969898A (en) | Buccal cigarette lozenge for preventing and treating dental ulcer and preparation method thereof | |
| CN105168809A (en) | Pharmaceutical composition for treatment of onychomycosis | |
| CN110433212A (en) | A kind of preparation method of xingren zhike syrup |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190521 |
|
| RJ01 | Rejection of invention patent application after publication |