CN109770134A - A kind of plant beverage of resisting ovarian failure and preparation method thereof - Google Patents
A kind of plant beverage of resisting ovarian failure and preparation method thereof Download PDFInfo
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Abstract
A kind of plant beverage of resisting ovarian failure and preparation method thereof, the raw material including following parts by weight: 0.8-1.5 parts of mulberry juice, 6-7 parts of lemon juice, 6-7 parts of ginger juice, 6-7 parts of honey, rich 80-90 parts of strontium water, 5-8 parts of xylitol, 0.09-0.15 parts of tea extract, 3-9 parts of Chinese medical extract, 0.002-0.006 parts of Sucralose, 0.1-0.15 parts of isoflavones, 0.3-5 parts of konjaku flour, 0.45-5.21 parts of food additives.Plant beverage Multiple components scientific compatibility of the present invention, it can tonifying liver, kidney-nourishing, nourishing yin and supplementing blood, nourish ovary, keep body endocrine normal, and uterine cell can be nourished, activity is improved, delay menopause, it enhances human immunity, promotes blood circulation simultaneously, invigorating qi for consolidating superficies keeps function health and the coordination of each tract of whole body.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of plant beverage of resisting ovarian failure and preparation method thereof.
Background technique
Premature ovarian failure, which refers to women once, the natural menstrual cycle, and occurs ovarian atrophy before 45 years old through measuring
It reduces, menstrual period shorten, and the menstrual cycle increases, until continuing amenorrhoea, the cause of disease may be infection, iatrogenic premature ovarian failure, idiopathic
Premature ovarian failure and immune factor etc..Premature ovarian failure clinical signs secondary sex characters is shunk back, and face is occurred and is warmed, is vexed, is easy
The menopause symptoms such as anger, usually easy catching a cold, blood follicular stimulating hormone level increase, and up to more than 40 units, are equivalent to postmenopausal women
Level, and blood estradiol is horizontal significant low, irregular menstruation is the earliest indication of ovarian failure.
Hormone replacement therapy is the important method of current Modern medical therapy ovarian-senescence related symptoms and disease, but is supplemented
Estrogen cannot effect a permanent cure, and can only improve symptom, be unable to improve the function of ovary, and long-term a large amount of complementing estrogens can not only give
Body brings certain side effect, while ovary also being made to be in dependent status, and after drug stops, itself lacks estrogen
Situation may be worse, or even has and lead to the worse possibility of ovarian function, also, existing research shows that hormone therapy have it is more
Kind side effect and carcinogenicity at a specified future date, clinical application are subject to significant restrictions.Chinese medicine thinks, the interpretation of the cause, onset and process of an illness and kidney of premature ovarian failure
Water is insufficient, liver-yang Kang Sheng is related, kidney water deficiency, and usually yin essence is deficient, a series of deficiency of Yin symptom occurs, this warms with face,
Vexed, not firm, tinnitus etc. of sleeping is consistent, and the deficiency of Yin often leads to that sun is high, and kidney water cannot nourish edema with the liver involved, also result in liver-yang naturally
Rising.
Summary of the invention
The purpose of the present invention is to provide plant beverage of a kind of resisting ovarian failure and preparation method thereof, plant drinks
Product nourishing yin and supplementing blood nourishes ovary, keeps body endocrine normal, and can nourish uterine cell, improves activity, delays menopause, together
When enhance human immunity, promote blood circulation, invigorating qi for consolidating superficies.
The technical solution adopted by the invention is as follows:
A kind of plant beverage of resisting ovarian failure, the raw material including following parts by weight: 0.8-1.5 parts of mulberry juice,
6-7 parts of lemon juice, 6-7 parts of ginger juice, 6-7 parts of honey, rich 80-90 parts of strontium water, 5-8 parts of xylitol, tea extract 0.09-
0.15 part, 3-9 parts of Chinese medical extract, 0.002-0.006 parts of Sucralose, 0.1-0.15 parts of isoflavones, konjaku flour 0.3-5
Part, 0.45-5.21 parts of food additives；The Chinese medical extract is extracted by Traditional Chinese drug mixture, Traditional Chinese drug mixture include with
The Chinese medicine of lower parts by weight: 0.03-0.04 parts of perilla leaf, 0.03-0.04 parts of Fructus Forsythiae, 0.03-0.04 parts of rosemary, cassia seed
0.03-0.04 parts, 0.03-0.04 parts of lophatherum gracile, 0.1-0.15 parts of ginkgo, 0.3-0.4 parts of Radix Angelicae Sinensis.
Further, food addition includes nisin 0.1-0.15 parts, 0.3-5 parts of cycloheptaamylose, sorbic acid
0.05-0.06 parts of potassium.
A kind of plant beverage of resisting ovarian failure, the raw material including following parts by weight: 1 part of mulberry juice, lemon juice
6.2 parts, 6.3 parts of ginger juice, 6.5 parts of honey, rich 86 parts of strontium water, 6 parts of xylitol, 0.12 part of tea extract, Chinese medical extract 6
Part, 0.004 part of Sucralose, 0.12 part of isoflavones, 2 parts of konjaku flour, 2 parts of food additives, including nisin
0.15 part, 1.8 parts of cycloheptaamylose, 0.05 part of potassium sorbate；The Chinese medical extract is extracted by Traditional Chinese drug mixture, Chinese medicine
Mixture includes the Chinese medicine of following parts by weight: 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, 0.04 part of rosemary, cassia seed 0.03
Part, 0.03 part of lophatherum gracile, 0.12 part of ginkgo, 0.4 part of Radix Angelicae Sinensis.
Inventive formulation pharmacological action is as follows:
Mulberries: it is sweet, sour, it trembles with fear, return heart, liver and kidney channel.Tonifying liver, kidney-nourishing, enriching yin of enriching blood, fluid dryness control liver-kidney Yin deficiency, disappear
Yearningly, constipation, mesh is dark, tinnitus, scrofula, articular instability, enhances immune function.
Lemon: acid, sweet and neutral.Preventing phlegm from forming and stopping coughing, stomach invigorating of promoting the production of body fluid are used for bronchitis, pertussis, loss of appetite, Vitamin C
Deficiency disease, heatstroke polydipsia.
Ginger: pungent, tepor, return lung, spleen, stomach meridian.Relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, preventing phlegm from forming and stopping coughing are used for anemofrigid cold, stomach
Cold vomiting, cold productive cough are coughed.
Honey: sweet and neutral.Return lung, spleen, large intestine channel.Bowl spares is moisturized, and is relieved pain, removing toxic substances, empty bitterly for stomach duct and abdomen, dryness of the lung dry cough,
Dry constipation of intestines.
Isoflavones: isoflavones is typical phytoestrogen, and isoflavones can replace estrogen in conjunction with ER
Estrogen-like action is played, and can interfere estrogen in conjunction with ER, shows as the effect of antiestrogenic sample.Isoflavones shows female
Hormonal activity or antiestrogenic depend primarily on the hormone metabolism state of study subject itself, to the horizontal person of high estrogen,
Such as the animal and young woman of young animals and estrogen, antiestrogenic is shown, to estrogen level junior, such as children
Toy, removal ovary animal, menopausal women show estrogenic activity.The estrogen-like action of isoflavones is to elderly woman
Many and Hormone Withdrawal moves back relevant disease such as blood lipid raising, atherosclerosis and osteoporosis etc., has certain prevention and controls
Treatment effect, isoflavones compound can improve myocardial ischemia symptom by different approach, and expansion blood vessel inhibits blood platelet solidifying
It is poly-, blood cholesterol and content of triglyceride are reduced, and there is anti-arrhythmia cordis to act on.
Konjaku flour: konjaku has hypoglycemic, reducing blood lipid, decompression, dissipates poison, beauty treatment, promote blood circulation, lose weight, defaecation, more function such as appetizing
Energy.
Rich strontium water: strontium is a kind of alkalescent microelement, and human body supplements strontium in right amount, can increase intracorporal alkaline element, in
And acidic constitution, so as to improve the sub-health state of human body, strontium also has the function of anti-oxidant anti-aging, can also reduce liver
Wound, has the function of relieving the effect of alcohol, sober up, and by adding rich strontium water, supplements strontium element for human body, adjusts human acid-base balance.
Tea extract: main component is tea polyphenols, by improving human immunoglobulin's total amount and it being made to maintain height
Level, stimulates the variation of antibody activity, to improve the overall immune ability of people, inhibits and kill the various nocuousness for causing diarrhea
Pathogen, and the tense situation for stomach of releiving, to achieve the effect that anti-inflammatory antidiarrheal.Flavanols compounds can pierce in tea polyphenols
Swash Renal vascular diastole, increase the blood flow of kidney, to increase the filtration rate of glomerulus, exclude the lactic acid in urine,
Lactic acid in human muscle, tissue is a kind of fatigue substances, and lactic acid, which excretes, can be such that the human body of fatigue is restored.
Perilla leaf: acrid in flavour and warm in nature, return lung, the spleen channel.Relieving exterior syndrome and dispelling cold, relieving QI stagnancy in the stomach are used for anemofrigid cold, and evil of vomitting of coughing, gestation is vomitted
It spits, fish and crab poisoning, there is refrigeration function, bacteriostasis, promote enterocinesia.
Fructus Forsythiae: bitter, slightly cold, return lung, the heart, small intestinl channel.Clearing heat and detoxicating, dispersing swelling and dissipating binds are used for ulcer, scrofula, acute mastitis, pellet
Poison, anemopyretic cold, warm disease is from the beginning of warm is joined the army, hyperpyrexia polydipsia, coma macular eruption, heat gonorrhea renal shutdown, has antibacterial, antivirus action.
Rosemary: acrid flavour, it is warm-natured.Sweating, invigorating the spleen are calmed the nerves, and analgesic has the function of to urge through to involutional neurological disorders
Caused hypomenorrhia or menopause can accelerate menstrual onset with this.Repeatedly fragrant alkali can also reinforce corticocerebral process of inhibition for choosing,
There are hypnosis, anticonvulsant action.The volatile oil of rosemary leave has antibacterial action.
Cassia seed: it is sweet, bitter, salty, it is slightly cold, return liver, large intestine channel, heat-clearing improving eyesight, relax bowel and defecation is used for the puckery pain of hot eyes, photophobia
More tears, headache and dizziness, mesh is secretly unknown, constipation.
Lophatherum gracile: cold in nature, sweet in flavor, light, thoughts of returning home warp, stomach meridian, small intestinl channel.Clearing heat and relieving fidgetness, diuresis.
Ginkgo: it is sweet, bitter, puckery, it puts down, distributed in heart and lung channels.Astringing lung-QI is relievingd asthma, activating microcirculation and removing stasis medicinal, and analgesic is used for deficiency syndrome of the lung cough and asthma, coronary disease
Disease, angina pectoris, hyperlipidemia.
Radix Angelicae Sinensis: sweet, acrid, warm returns liver, the heart, the spleen channel.Replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels are used for blood deficiency chlorosis, dizzy
Dizzy palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, dry constipation of intestines, rheumatic arthralgia, injury from falling down, ulcer sores.
Mulberry juice master of the present invention enters liver kidney, tonifying liver, kidney-nourishing, enriching yin of enriching blood, and tea extract stimulation of renal vasodilation increases
The blood flow of kidney, and the two can improve the immunity of the human body, the rosemary in Chinese medical extract has the function of to urge through Radix Angelicae Sinensis is mended
Blood promoting blood circulation, menstruction regulating and pain relieving, isoflavones adjust estrogen level, improve estrogen metabolism, and Multiple components scientific compatibility reaches
The effect of resisting ovarian failure, and Chinese medical extract antibacterial, antiviral efficacy are effectively relieved ovarian function caused by infection and decline
It moves back, separately plus the relieving exterior syndrome and dispelling colds such as lemon juice, ginger juice, perilla leaf, relieving QI stagnancy in the stomach, the profit such as honey, perilla leaf, konjaku flour, cassia seed
Intestines defaecation, rich strontium water improve the sub-health state of human body, enhance general immunity, keep the function health of each tract of whole body
With coordination.
Further, Traditional Chinese drug mixture further includes 0.1-0.15 parts of pueraria lobata, 0.1-0.15 parts of Radix Glycyrrhizae, fennel seeds 0.3-0.4
Part, 0.1-0.2 parts of tremella, 0.3-0.4 parts of saponin rice.Pueraria lobata expelling pathogenic factors from muscles and skin brings down a fever, promotes the production of body fluid, promoting eruption, Shengyang Zhixie.Radix Glycyrrhizae tonifying spleen benefit
Gas, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.Fennel seeds cold-dispelling pain-relieving, regulating qi-flowing for harmonizing stomach, sexual hormonelike are made
With fennel oil can be such that its liver regeneration degree increases.Tremella nourishing is promoted the production of body fluid, and moistening lung nourishing the stomach can promote liver RNA to synthesize, and delay senescence,
Saponin rice promotes enterogastric peristalsis, accelerates defecation, and reducing phlegm and resolving masses prevents blood glucose rise, further increased by adding this five kinds of ingredients
The effect of the strong plant beverage resisting ovarian failure, and it is normal to adjust endocrine.
Further, Traditional Chinese drug mixture further includes 0.1-0.2 parts of Rosa roxburghii Tratt, 4-7 parts of quinoa, 3-6 parts of seaweed, Herba Epimedii 0.1-
1.0 part.Rosa roxburghii Tratt can enhance body's immunity, go back delaying sanility, eliminate fatigue, improve and sleep, add enthusiasm, eliminating color
Spot, the multi-effects such as beauty treatment skin, has the effect of strengthening body.Quinoa can alleviate vascular pressure, and preventing hypertension reduces
Cholesterol has good health-care efficacy.Cellular immunity and humoral immune function is remarkably reinforced in seaweed, has reducing blood lipid, delays
The effects of aging, hypoglycemic, anti-liver injury, Herba Epimedii have the effects that resisting pathogenic microbes, delay senescence, and these types of ingredient is matched
5, reach the effect of keeping fit and healthy, further to prevent ovarian failure.
Further, Traditional Chinese drug mixture further includes 2-5 parts of Herba Cistanches, 3-7 parts of Radix Astragali, 10-20 parts of motherwort, lily 0.1-
0.15 part.Herba Cistanches can enhance body fluid and cellular immune function, have and delay senescence, decompression, resist and dash forward, adjustment endocrine, promote
The effect of metabolism, Radix Astragali have the effects that anti-oxidant, antiviral, anticancer, improve renal function and renal pathology change, motherwort
Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema, lily Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing, the formula is by improving immunity, adjusting endocrine, delaying
Aging, improvement renal function etc. further enhance the effect of resisting ovarian failure.
Further, Traditional Chinese drug mixture further includes 0.4-0.5 parts of fructus lycii, 2-5 parts of American Ginseng, 5-6 parts of jujube, fig 3-
5 parts, 5-7 parts of sanchi flower, 0.5-3 parts of hawthorn, 0.3-2 parts of Pollen Typhae.Fructus lycii is nourishing liver and kidney, benefiting shrewd head, and American Ginseng tonifying Qi is supported
Yin, clearing heat and promoting fluid, jujube tonifying middle-Jiao and Qi, nourishing blood and tranquilization, fig invigorating stomach and promoting bower movements, subdhing swelling and detoxicating, sanchi flower heat-clearing, calming the liver, drop
Pressure, hawthorn digesting stomach invigorating, scattered stasis, Pollen Typhae activating microcirculation and removing stasis medicinal, inducing diuresis for treating strangurtia, the formula enhance liver-kidney tonifying, Yin-nourishing and Qi-supplementing
The effect of.
Further, Traditional Chinese drug mixture further includes 0.1-0.15 parts of longan, 0.5-2 parts of brown sugar, 1-5 parts of Cordyceps militaris, safflower
1-5 parts, 2-3 parts of selenium malt.Longan nourishing the heart and spleen, replenishing qi and blood, strengthening the spleen and stomach, nourishing the muscles, brown sugar are enriched blood, toxin expelling, active qi and blood, are accelerated
Blood circulation and skin cell metabolism, Cordyceps militaris tonifying lung yin, kidney-replenishing, delay senescence, safflower blood circulation, removing blood stasis and acesodyne, selenium
Malt is anti-oxidant, anticancer, the formula mainly further enhance enrich blood, effect of invigorating blood circulation.
A kind of preparation method of the plant beverage of resisting ovarian failure, which comprises the following steps:
(1) mulberries, lemon, ginger are cleaned into broken wall respectively and takes juice, 60 DEG C are cooled to after decoction hereinafter, to weigh formula ratio standby
With；
(2) tea extract and Chinese medical extract of formula ratio are weighed, is added into 30-50 parts of rich strontium water, and heat and stir
It mixes uniformly, it is spare；
(3) honey, xylitol, Sucralose, isoflavones, konjaku flour, the food additives of formula ratio are weighed, are added
Into 20-25 parts of rich strontium water, and heating stirring is uniform, spare；
(4) solution that step (1)-(3) obtain is added into preparing tank, remaining rich strontium water is added, stirs evenly, so
It filters, sterilized to get the plant beverage of resisting ovarian failure afterwards.
Further, in step (2), heating temperature is 60 DEG C.
Further, in step (3), heating temperature is 40 DEG C.
Further, the plant beverage of resisting ovarian failure can also be prepared as capsule, soaked liquor, vinegar ball, wine ball, honey
Ball.
Further, further include 9-10 parts of making vinegar, the residue that step (1) and step (4) obtain is placed in brewing food
Post-processing is impregnated in vinegar into powder, and is packaged into capsule.
In conclusion by adopting the above-described technical solution, the beneficial effects of the present invention are:
1. plant beverage Multiple components scientific compatibility of the present invention, can tonifying liver, kidney-nourishing, nourishing yin and supplementing blood, nourish ovary, keep body
Secretion is normal in vivo, and can nourish uterine cell, improve activity, delay menopause, enhances human immunity simultaneously, blood is promoted to follow
Ring, invigorating qi for consolidating superficies keep function health and the coordination of each tract of whole body；
2. Traditional Chinese drug mixture of the present invention can also have strengthen immunity by addition, adjust endocrine, liver-kidney tonifying, enriching yin
Tonifying Qi, the ingredient enriched blood, invigorated blood circulation and other effects further increase the effect of resisting ovarian failure；
3, according to Traditional Chinese Medicine compatibility theory, the functionality of selected " in Compendium of Materia Medica " food and medicine consangunity is specific to plant the present invention
Object scientific composition precisely measures, product functionality and safety is effectively ensured.
Detailed description of the invention
Fig. 1 is mouse hair, color situation of change.
Specific embodiment
All features disclosed in this specification can be with any other than mutually exclusive feature and/or step
Mode combines.
Embodiment 1
A kind of preparation method of the plant beverage of resisting ovarian failure, comprising the following steps:
(1) by 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, 0.04 part of rosemary, 0.03 part of cassia seed, 0.03 part of lophatherum gracile,
It is heated to impregnating 20 days in white wine after 0.12 part of ginkgo, Radix Angelicae Sinensis 0.4 part of broken wall, milling, filters, distills, being concentrated, being drying to obtain
Medicament extract；
(2) mulberries, lemon, ginger are cleaned into broken wall respectively and takes juice, 60 DEG C are cooled to after decoction hereinafter, weighing mulberry juice 1
Part, 6.2 parts of lemon juice, 6.3 parts of ginger juice it is spare；
(3) 0.12 part and 6 parts of Chinese medical extract of tea extract is weighed, is added into 40 parts of rich strontium water, and at 60 DEG C
At a temperature of stir evenly, it is spare；
(4) 6.5 parts of honey, 6 parts of xylitol, 0.004 part of Sucralose, 0.12 part of isoflavones, konjaku flour 2 are weighed
Part, 0.15 part of nisin, 1.8 parts of cycloheptaamylose, 0.05 part of potassium sorbate are added into 20 parts of rich strontium water, and
It is stirred evenly at a temperature of 40 DEG C, it is spare；
(5) solution that step (2)-(4) obtain is added into preparing tank, remaining 26 parts rich strontium water is added, stir evenly,
Then it filters, sterilize to get the plant beverage of resisting ovarian failure, the residue that step (2) and step (5) obtain is placed in 9 parts
Post-processing is impregnated in making vinegar into powder, and is packaged into capsule.
Embodiment 2
A kind of preparation method of the plant beverage of resisting ovarian failure, comprising the following steps:
(1) by 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, 0.04 part of rosemary, 0.03 part of cassia seed, 0.03 part of lophatherum gracile,
It is heated to impregnating 20 days in white wine after 0.12 part of ginkgo, Radix Angelicae Sinensis 0.4 part of broken wall, milling, filters, distills, being concentrated, being drying to obtain
Medicament extract；
(2) mulberries, lemon, ginger are cleaned into broken wall respectively and takes juice, 60 DEG C are cooled to after decoction hereinafter, weighing mulberry juice
0.8 part, 6 parts of lemon juice, 6 parts of ginger juice it is spare；
(3) 0.09 part and 3 parts of Chinese medical extract of tea extract is weighed, is added into 30 parts of rich strontium water, and at 60 DEG C
At a temperature of stir evenly, it is spare；
(4) weigh 6 parts of honey, 5 parts of xylitol, 0.002 part of Sucralose, 0.1 part of isoflavones, 0.5 part of konjaku flour,
0.1 part of nisin, 0.3 part of cycloheptaamylose, 0.05 part of potassium sorbate are added into 20 parts of rich strontium water, and at 40 DEG C
At a temperature of stir evenly, it is spare；
(5) solution that step (2)-(4) obtain is added into preparing tank, remaining 30 parts rich strontium water is added, stir evenly,
Then it filters, sterilize to get the plant beverage of resisting ovarian failure, the residue that step (2) and step (5) obtain is placed in 9 parts
Post-processing is impregnated in making vinegar into powder, and is packaged into capsule.
Embodiment 3
A kind of preparation method of the plant beverage of resisting ovarian failure, comprising the following steps:
(1) by 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, 0.04 part of rosemary, 0.03 part of cassia seed, 0.03 part of lophatherum gracile,
It is heated to impregnating 20 days in white wine after 0.12 part of ginkgo, Radix Angelicae Sinensis 0.4 part of broken wall, milling, filters, distills, being concentrated, being drying to obtain
Medicament extract；
(2) mulberries, lemon, ginger are cleaned into broken wall respectively and takes juice, 60 DEG C are cooled to after decoction hereinafter, weighing mulberry juice
1.5 parts, 7 parts of lemon juice, 7 parts of ginger juice it is spare；
(3) 0.15 part and 9 parts of Chinese medical extract of tea extract is weighed, is added into 50 parts of rich strontium water, and at 60 DEG C
At a temperature of stir evenly, it is spare；
(4) 7 parts of honey, 8 parts of xylitol, 0.006 part of Sucralose, 0.15 part of isoflavones, konjaku flour 4.5 are weighed
Part, 0.15 part of nisin, 5 parts of cycloheptaamylose, 0.06 part of potassium sorbate are added into 25 parts of rich strontium water, and 40
It is stirred evenly at a temperature of DEG C, it is spare；
(5) solution that step (2)-(4) obtain is added into preparing tank, remaining 15 parts rich strontium water is added, stir evenly,
Then it filters, sterilize to get the plant beverage of resisting ovarian failure, by plant beverage concentration, sterilizing post package at capsule,
The residue that step (2) and step (5) obtain, which is placed in 9 parts of making vinegars, impregnates post-processing into powder, and is packaged into capsule.
Embodiment 4
The present embodiment and the difference of embodiment 1 are only that: Chinese medical extract is by 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, fan
Repeatedly fragrant 0.04 part, 0.03 part of cassia seed, 0.03 part of lophatherum gracile, 0.12 part of ginkgo, 0.4 part of Radix Angelicae Sinensis, 0.1 part of pueraria lobata, Radix Glycyrrhizae 0.15
It is heated to impregnating 20 days in white wine after part, 0.35 part of fennel seeds, 0.15 part of tremella, saponin rice 0.3 part of broken wall, milling, filtering is steamed
It evaporates, be concentrated, dry and obtain.
Embodiment 5
The present embodiment and the difference of embodiment 1 are only that: Chinese medical extract is by 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, fan
Repeatedly fragrant 0.04 part, 0.03 part of cassia seed, 0.03 part of lophatherum gracile, 0.12 part of ginkgo, 0.4 part of Radix Angelicae Sinensis, 0.2 part of Rosa roxburghii Tratt, quinoa 5.5
Be heated to impregnating 20 days in white wine after part, 4.5 parts of seaweed, Herba Epimedii 0.5 part of broken wall, milling, filtering, distillation, concentration, it is dry and
?.
Embodiment 6
The present embodiment and the difference of embodiment 1 are only that: Chinese medical extract is by 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, fan
Repeatedly fragrant 0.04 part, 0.03 part of cassia seed, 0.03 part of lophatherum gracile, 0.12 part of ginkgo, 0.4 part of Radix Angelicae Sinensis, 3.5 parts of Herba Cistanches, Radix Astragali 5
Be heated to impregnating 20 days in white wine after part, 15 parts of motherwort, lily 0.1 part of broken wall, milling, filtering, distillation, concentration, it is dry and
?.
Embodiment 7
The present embodiment and the difference of embodiment 1 are only that: Chinese medical extract is by 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, fan
Repeatedly fragrant 0.04 part, 0.03 part of cassia seed, 0.03 part of lophatherum gracile, 0.12 part of ginkgo, 0.4 part of Radix Angelicae Sinensis, 0.4 part of fructus lycii, American Ginseng 3
It is heated to impregnating in white wine after part, 5 parts of jujube, 4 parts of fig, 6 parts of sanchi flower, 2 parts of hawthorn, Pollen Typhae 1.2 parts of broken walls, millings
20 days, filtering, concentration, was dried and is obtained distillation.
Embodiment 8
The present embodiment and the difference of embodiment 1 are only that: Chinese medical extract is by 0.03 part of perilla leaf, 0.04 part of Fructus Forsythiae, fan
Repeatedly fragrant 0.04 part, 0.03 part of cassia seed, 0.03 part of lophatherum gracile, 0.12 part of ginkgo, 0.4 part of Radix Angelicae Sinensis, 0.1 part of longan, 1 part of brown sugar,
It is heated to impregnating 20 days in white wine after 3 parts of Cordyceps militaris, 3 parts of safflower, selenium malt 2 parts of broken walls, millings, filtering, concentration, is done distillation
It is dry and obtain.
Embodiment 9
One, experimental material:
1, reagent:
0.9wt% physiological saline；
Estradiol valerate tablet (Progynova), specification 1mg/ piece, product batch number 397A, producer DELPHARM LI LLE
S.A.S, purchase are configured to the solution of 0.01mg/ml, 4 DEG C of preservations with distilled water from affiliated hospital, southwestern medical university；
Syklofosfamid ampoule (endoxan), specification 0.2g/ branch, batch number 8A211A, producer Baxter onco
Logy Gmbh, purchase is saved from affiliated hospital, southwestern medical university, 4 DEG C, in use, being infused with 10ml 0.9wt% physiological saline
Enter ampere bottle, after dissolution, take 4.5ml stoste, with 5.5ml normal saline dilution at the solution of 9mg/ml；
Plant beverage prepared by embodiment 1；
Anti- Miao Le formula pipe hormone (AMH) detection kit (enzyme-linked immunosorbent assay), article No. CEA228Mu, brand are excellent
You are raw, 96 hole of specification；
Auspicious formula dye liquor, article No. G1040, brand Suo Laibao, specification 500ml；
4% paraformaldehyde, article No. BL539A, brand biosharp, specification 500ml；
It adheres to glass slide (25*75mm), article No. 188105W, brand generation is safe.
2, animal: 6-8 weeks C57 female mice 40 (buying from Chongqing Teng Xin Bioisystech Co., Ltd) is classified as
Normal group (physiological saline), model control group (physiological saline), positive controls (estradiol valerate tablet), experimental group are (real
Apply the plant beverage of the preparation of example 1), every group of 10 mouse；
Two, test method
1, modeling: model control group, positive controls and experimental mice use disposable celiac injection method, with 90mg/
Kg dose Cyclophosphamide replicates the animal model of follicular development obstacle caused by Ovary reserve declines；
2, it tests: recording Mouse Oestrous Cycle variation from second day starting row vaginal exfoliated smear after modeling
Situation, while observing activity, diet and the fur variation of each group mouse.All mouse continue stomach-filling 30 days, every 0.3ml/ days/
It is secondary, wherein Normal group and model control group physiological saline stomach-filling.Second day execution mouse after stomach-filling, detection are anti-
Miao Le formula pipe hormone (AMH) is horizontal, after blood sampling, wins mouse bilateral ovaries tissue, weighs ovary weight in wet base, uses after ovary weighing
4% paraformaldehyde is fixed, wax embedding, and wax stone is cut into the thin slice of 4 μ m-thicks, HE dyeing.
Vaginal smear method: mousetail root has been pinched with left hand thumb and index finger and has been lifted, has been placed on Mouse cage cover, in mouse
When creeping forward, left hand lifts rat-tail, and palm pins head and back, fixes in handstand shape；The right hand draws 10 μ with pipettor
L0.9wt% physiological saline is slowly inserted in 1-2mm at mouse vagina internal orifice, aspirates 3-4 times repeatedly, then by the rifle of pipettor
Liquid in head is uniformly applied on glass slide；Vaginal smear is dyed using auspicious formula decoration method, finally puts down glass slide
It is put in and vagina epithelium cast-off cells situation is observed and recorded under inverted microscope.
Mouse vagina smear epithelial cell Variation Features: preoestrus is almost to have core superficial cell entirely, it is seen that few
Measure seedless superficial cell；Estrus is almost seedless superficial cell entirely, occasionally there is core epithelial cell；Metaoestrus,
Superficial cell is reduced, it is seen that a small amount of leucocyte and a small amount of mucus；Anoestrum, superficial cell are reduced, and cytoplasm is reduced
Shrinkage, it is seen that a large amount of leucocytes and more mucus.
Statistical analysis method: test data indicates that data analyze software using SPSS9.0, between group using Mean ± SEM
Compare, measurement data does normality and homogeneity test of variance first, meets homogeneity of variance, carries out variance using single-factor analysis therapy
Analysis is unsatisfactory for homogeneity of variance and is examined using nonparametric method.
3, test result:
(1) the reproducible female mice Ovary reserve decline model of the method disposably injected using CTX row abdominal cavity: normal right
Normal according to group mouse diet amount, fur is dry and comfortable smooth, and the state of mind is good, and stool is in black wheat shape, other group of mouse appetite
Decline, fur, which is made soaked with sweat, erects sparse, apathetic, hunchbacked atrophy, and happiness is crowded sleeping dynamic without liking, and burnout is drowsiness, syntexis, big loose stool,
In light gray.Except for the normal group, because stomach-filling is improper after modeling, dead two.Cyclophosphamide is injected under female mice abdominal cavity causes ovary storage
Standby function reduction model success.
(2) plant beverage of the present invention can be effectively improved Mouse Oestrous Cycle disturbance state: Normal group mouse is emotionally all
Phase stablizes at 4-5 days or so, and model control group mouse oestrous cycle after chemotherapy modeling gets muddled, cycle stretch-out to 8-11
It, experimental mice oestrous cycle disturbance state is improved, and more regular oestrous cycle alternating occurs, and the time is 6-9 days.
(3) it is dull can be effectively improved hypotrichosis caused by Ovary reserve declines, color for plant beverage of the present invention: as schemed
Shown in 1, cyclophosphamide inducing mouse ovarian failure, chaeta is intense darkness without light, bleaches, and takes plant beverage of the present invention, hair color
Normally, it is evenly distributed, effect is better than positive controls.
(4) effect of the plant beverage of the present invention to mice serum AMH level: Normal group AMH is 0.48 ± 0.02ng/
Ml, model control group AMH are 0.34 ± 0.03ng/ml, and positive controls AMH is 0.41 ± 0.02ng/ml, and experimental group AMH is
0.42±0.01ng/ml.The AMH value of model control group is significantly lower than Normal group (P < 0.05), illustrates cyclophosphamide to it
Ovary causes toxicity damage, accelerates follicle number sharply to decline so as to cause Ovary reserve decline.Experimental group and positive control
The AMH value of group is above model control group (P<0.05), and the AMH value of experimental group and positive controls is suitable (P>0.05), explanation
Ovary reserve can be effectively improved by taking plant beverage of the present invention.
Embodiment 10
Plant beverage prepared by embodiment 1 is encapsulated as oral solution, 50ml/ branch, daily one, one month is a conditioning
Period.Typical case is as follows:
One, Zhang, female 48 years old, are up to time menstrual disorder more than 2 years, take menopause half a year before plant beverage of the present invention
It is more, every physical examination index: 1. flitropins<FSH>: 41.20 (being in menopause)；2, estradiol: < 73.4 is (in exhausted
Menstrual period)；3, anti-Miao Le Shi: 0.06 (being in luteal phase)；4, blood glucose: 6.01.Continuously take plant beverage of the present invention 22 days later
Menstruation, after two conditioning periods, menstrual period are punctual, and menstrual flow is normal, and blood glucose is declined slightly, every physical examination index: 1. promote ovarian follicle thorn
Hormone<FSH>: 20.67 (being in the onset of ovulation)；2, estradiol: 1317 (being in the onset of ovulation) 3, anti-Miao Le Shi: 0.09 (are in corpus luteum
Phase)；4, blood glucose: 5.9.
Two, Ma, female, 50 years old, menopause was up to the time more than 1 year before taking plant beverage of the present invention, every physical examination index:
1. flitropin<FSH>: 87.24 (being in menopause)；2, estradiol: 10 (being in menopause)；3, anti-Miao Le Shi: 0.10
(being in menopause).Plant beverage of the present invention is continuously taken after one month, flitropin<FSH>decline 10 or so, ovary
Function is restored, every physical examination index: 1. flitropins<FSH>: 77.42 (being in menopause)；2, estradiol: 10
(being in menopause)；3, anti-Miao Le Shi: 0.10 (being in menopause).
Three, week so-and-so, female, 44 years old, every physical examination index before taking plant beverage of the present invention: 1. flitropins <
FSH>:4.56；2, estradiol: 215；3, anti-Miao Le Shi: 1.37；4, blood glucose: 4.33.Continuously take plant beverage one of the present invention
After month, flitropin<FSH>decline, estradiol increases, ovarian function recovery, every physical examination index: 1. promote ovarian follicle stimulation
Plain<FSH>: 3.53；2, estradiol: 249；3, anti-Miao Le Shi: 1.01；4, blood glucose: 4.33.
Four, Mr. Li, female, 39 years old, every physical examination index before taking plant beverage of the present invention: 1. flitropins <
FSH>:8.579；2, estradiol: 62.17；3, blood glucose: 5.91.Plant beverage of the present invention is continuously taken after one month, promotees ovarian follicle thorn
Hormone<FSH>is from follicular phase promotion to the onset of ovulation, and blood glucose drops to 4.6 from 5.91, these bodies for all embodying experiencer are in
Recovery state, every physical examination index: 1. flitropins<FSH>: 11.26；2, estradiol: 2095；3, blood glucose: 4.6.
It is as described above the embodiment of the present invention.The present invention is not limited to the above-described embodiments, anyone should learn that
The structure change made under the inspiration of the present invention, the technical schemes that are same or similar to the present invention each fall within this
Within the protection scope of invention.
Claims (9)
1. a kind of plant beverage of resisting ovarian failure, which is characterized in that the raw material including following parts by weight: mulberry juice
0.8-1.5 parts, 6-7 parts of lemon juice, 6-7 parts of ginger juice, 6-7 parts of honey, rich 80-90 parts of strontium water, 5-8 parts of xylitol, tealeaves mentions
Take 0.09-0.15 parts of object, 3-9 parts of Chinese medical extract, 0.002-0.006 parts of Sucralose, 0.1-0.15 parts of isoflavones, evil spirit
0.3-5 parts of taro powder, 0.45-5.21 parts of food additives；
The Chinese medical extract is extracted by Traditional Chinese drug mixture, and Traditional Chinese drug mixture includes the Chinese medicine of following parts by weight: purple perilla
0.03-0.04 parts of leaf, 0.03-0.04 parts of Fructus Forsythiae, 0.03-0.04 parts of rosemary, 0.03-0.04 parts of cassia seed, lophatherum gracile 0.03-
0.04 part, 0.1-0.15 parts of ginkgo, 0.3-0.4 parts of Radix Angelicae Sinensis.
2. a kind of plant beverage of resisting ovarian failure according to claim 1, which is characterized in that the food addition
Including 0.1-0.15 parts of nisin, 0.3-5 parts of cycloheptaamylose, 0.05-0.06 parts of potassium sorbate.
3. a kind of plant beverage of resisting ovarian failure according to claim 1, which is characterized in that the Chinese medicine mixing
Object further includes 0.1-0.15 parts of pueraria lobata, 0.1-0.15 parts of Radix Glycyrrhizae, 0.3-0.4 parts of fennel seeds, 0.1-0.2 parts of tremella, saponin rice
0.3-0.4 parts.
4. a kind of plant beverage of resisting ovarian failure according to claim 1, which is characterized in that the Chinese medicine mixing
Object further includes 0.1-0.2 parts of Rosa roxburghii Tratt, 4-7 parts of quinoa, 3-6 parts of seaweed, 0.1-1.0 parts of Herba Epimedii.
5. a kind of plant beverage of resisting ovarian failure according to claim 1, which is characterized in that the Chinese medicine mixing
Object further includes 2-5 parts of Herba Cistanches, 3-7 parts of Radix Astragali, 10-20 parts of motherwort, 0.1-0.15 parts of lily.
6. a kind of plant beverage of resisting ovarian failure according to claim 1, which is characterized in that the Chinese medicine mixing
Object further includes 0.4-0.5 parts of fructus lycii, 2-5 parts of American Ginseng, 5-6 parts of jujube, 3-5 parts of fig, 5-7 parts of sanchi flower, hawthorn 0.5-3
Part, 0.3-2 parts of Pollen Typhae.
7. a kind of plant beverage of resisting ovarian failure according to claim 1, which is characterized in that the Chinese medicine mixing
Object further includes 0.1-0.15 parts of longan, 0.5-2 parts of brown sugar, 1-5 parts of Cordyceps militaris, 1-5 parts of safflower, 2-3 parts of selenium malt.
8. a kind of preparation method of the plant beverage of the resisting ovarian failure as described in any one of claim 1-7, special
Sign is, comprising the following steps:
(1) mulberries, lemon, ginger are cleaned into broken wall respectively and takes juice, 60 DEG C are cooled to after decoction hereinafter, to weigh formula ratio spare；
(2) tea extract and Chinese medical extract of formula ratio are weighed, is added into 30-50 parts of rich strontium water, and heating stirring is equal
It is even, it is spare；
(3) honey, xylitol, Sucralose, isoflavones, konjaku flour, the food additives of formula ratio are weighed, are added extremely
In 20-25 parts of rich strontium water, and heating stirring is uniform, spare；
(4) solution that step (1)-(3) obtain is added into preparing tank, remaining rich strontium water is added, stirs evenly, then mistake
Filter sterilizes to get the plant beverage of resisting ovarian failure.
9. the preparation method of the plant beverage of resisting ovarian failure according to claim 8, which is characterized in that further include making
9-10 parts of vinegar are made, the residue that step (1) and step (4) obtain is placed in making vinegar and impregnates post-processing into powder, and is sealed
Dress up capsule.
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