CN109758554A - A kind of blood activating and fat reducing coronary dilatation expands blood vessel heart particle living and preparation method thereof - Google Patents
A kind of blood activating and fat reducing coronary dilatation expands blood vessel heart particle living and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of blood activating and fat reducing coronary dilatations to expand blood vessel heart particle living and preparation method thereof, the heart particle living and the component divided including following weight, 10~15g of rhizoma corydalis, 10~15g of peach kernel, 10~15g of safflower, 10~15g of Rhizoma Chuanxiong, 10~15g of radix paeoniae rubra, 15~20g of Radix Salviae Miltiorrhizae, 12~18g of Radix Angelicae Sinensis, 10~15g of Radix Rehmanniae, 10~15g of green peel, 10~15g of rhizoma cyperi, 3~8g of olibanum, 10~15g of ramulus cinnamomi, 3~8g of roud cardamon seed；The present invention also provides the preparation methods of above-mentioned heart particle living.Pathological characteristics of the present invention according to coronary heart disease, start with from activating microcirculation and removing stasis medicinal, regulating qi and dredging collateral, select Chinese herbal medicine reasonable compatibility, and the work heart particle of a kind of good drug efficacy, few side effects is provided, reducing blood lipid, coronary dilatation, the effect for expanding blood vessel can be played, to alleviate patients with coronary heart disease clinical symptoms.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of blood activating and fat reducing coronary dilatation to expand blood vessel heart particle living and its preparation
Method.
Background technique
Coronary heart disease, that is, coronary cardiopathy is the heart disease as caused by coronary artery pathological changes.Due to its morbidity
Rate is high, and the death rate is high, the health of the mankind is seriously endangered, to be referred to as " the first killers of the mankind ".
Coronary artery is first branch of aorta, supplies heart blood.In case of lesion cause luminal stenosis or
Occlusion, i.e. generation coronary circulation obstacle, keep myocardial blood insufficient, then cause heart disease, usual symptom have angina pectoris and
Palpitaition infraction.Angina pectoris is the temporary ischemic of heart sharply and clinical symptoms caused by but oxygen, and feature is before paroxysmal
Chest narrows or sensation of pain, is predominantly located at breastbone rear portion, can emit to shirtfront left upper extremity, and nitrous is rested or used to last for several minutes
It disappears after hydrochlorate preparation；Palpitaition infraction is to occur that part cardiac muscle because of severe persistent ischemic due to coronary artery acute occlusion
Local necrosis, clinically have violent and lasting retrosternal pain, shock, fever, leukocytosis, red blood cell sink color add
Fastly, sero-enzyme activity is increased and the performance such as progressive ECG Change.Both the above symptom is all because of coronary insufficiency
Caused by lesion, so treatment coronary heart disease should focus on activating microcirculation and removing stasis medicinal, adjustment softening it is coronarius hardening and removing lumen it is narrow
Narrow and occlusion.
The morbidity of coronary heart disease is increased with the growth at age, and degree is also aggravated with the growth at age.Data show that from
Start within 40 years old, every to increase by 10 years old, the illness rate of coronary heart disease increases 1 times.After male 50 years old, women 60 years old, coronary sclerosis hair
Open up it is rapider, the dangerous growth also with the age of same myocardial infarction and increase.
The World Health Organization is classified as follows coronary heart disease: primary cardiac all standing, angina pectoris, myocardial infarction, ischemic cardiac
Heart failure, arrhythmia cordis in popular name for.Though coronary heart disease is fallen ill after the middle age, lesion coronarius can also be originating from child
The ratio of epoch in year, brain worker and physical labourer's morbidity is about 2: 1.
When coronary heart disease qi depression to blood stasis, as twisted, fixed pain is very then chested pain radiating to the back for the common ambition sharp ache of disease, such as thorn,
Backache radiating to the heart, or pain draw shoulder back, are often accompanied by uncomfortable in chest, do not recover for a long time, and disease can aggravate due to violent rage, dimly red tongue, or purple dark, more
See ecchymosis, the sublingual visible channels stasis of blood is bent, and tongue fur is thin, stringy and hesitant pulse or knot, generation, rush.And in cardiovascular disease in recent years, most of patient
All there is the combination situation that high blood pressure, blood lipid are high, blood glucose is high, blood viscosity is big, using current drug therapy, needs various drug therapies
Side proves effective, and various side effects are full of contradictions.
For patients with coronary heart disease clinical symptoms are effectively relieved, it is badly in need of a kind of reducing blood lipid, coronary dilatation, the drug for expanding blood vessel at present.
Summary of the invention
The present invention provides one kind to solve problems of the prior art and can play reducing blood lipid, coronary dilatation, expand blood vessel
Effect, so that the blood activating and fat reducing coronary dilatation for alleviating patients with coronary heart disease clinical symptoms expands blood vessel heart particle living and preparation method thereof.
To achieve the above object, the invention adopts the following technical scheme:
The first purpose of the invention is to provide a kind of blood activating and fat reducing coronary dilatations to expand blood vessel heart particle living, including following weight point
Component, it is 10~15 parts of rhizoma corydalis, 10~15 parts of peach kernel, 10~15 parts of safflower, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of radix paeoniae rubra, red
Join 15~20 parts, 12~18 parts of Radix Angelicae Sinensis, 10~15 parts of Radix Rehmanniae, 10~15 parts of green peel, 10~15 parts of rhizoma cyperi, 3~8 parts of olibanum, osmanthus
10~15 parts, 3~8 parts of roud cardamon seed of branch.
In order to optimize above-mentioned technical solution, the technical measures that the present invention takes further include:
It is further preferred that the blood activating and fat reducing coronary dilatation expands blood vessel heart particle living, the component including following weight point is prolonged recklessly
10~12 parts of rope, 10~12 parts of peach kernel, 10~12 parts of safflower, 10~12 parts of Rhizoma Chuanxiong, 10~12 parts of radix paeoniae rubra, 15~17 parts of Radix Salviae Miltiorrhizae,
12~14 parts of Radix Angelicae Sinensis, 10~12 parts of Radix Rehmanniae, 10~12 parts of green peel, 10~12 parts of rhizoma cyperi, 3~5 parts of olibanum, 10~12 parts of ramulus cinnamomi,
3~5 parts of roud cardamon seed.
A second object of the present invention is to provide the preparation method that a kind of above-mentioned blood activating and fat reducing coronary dilatation expands blood vessel heart particle living,
The following steps are included:
Step 1, it according to formula rate, weighs the drug component other than roud cardamon seed and cleans, add 10~15 times of volume water loggings
Half an hour is steeped, is heated to slightly boiled, is kept for slightly boiled 1.5 hours, then roud cardamon seed is cleaned and is put into, then keep slightly boiled 0.5~1 small
When, medical fluid is obtained by filtration in the dregs of a decoction；
Step 2, medical fluid is made in step 1 and is cooled to 50~60 DEG C, being concentrated under reduced pressure into specific gravity is 1.06-1.08；
Step 3, the material after step 2 concentration is spray-dried using spray dryer, the air inlet of spray dryer
Temperature is 160~180 DEG C, and leaving air temp is 95~105 DEG C；
Step 4, it collects spray powder after step 3 drying, spray powder be crushed into 70~80 meshes；
Step 5, spray powder obtained in step 4 is prepared into capsule, tablet, pill or oral solution.
In order to optimize above-mentioned technical solution, the technical measures that the present invention takes further include:
It is further preferred that a kind of above-mentioned blood activating and fat reducing coronary dilatation expands the preparation method of blood vessel heart particle living, including following step
It is rapid:
Step 1, it according to formula rate, weighs the drug component other than roud cardamon seed and cleans, add 14~15 times of submission water loggings
Half an hour is steeped, is heated to slightly boiled, is kept for slightly boiled 1.5 hours, then roud cardamon seed is cleaned and is put into, then keep slightly boiled 0.8~1 small
When, medical fluid is obtained by filtration in the dregs of a decoction；
Step 2, medical fluid is made in step 1 and is cooled to 58~60 DEG C, being concentrated under reduced pressure into specific gravity is 1.07-1.08；
Step 3, the material after step 2 concentration is spray-dried using spray dryer, the air inlet of spray dryer
Temperature is 175~180 DEG C, and leaving air temp is 100~105 DEG C；
Step 4, it collects spray powder after step 3 drying, spray powder be crushed into 78~80 meshes；
Step 5, spray powder obtained in step 4 is prepared into capsule, tablet, pill or oral solution.
It is further preferred that optionally increasing suitable food thickening agent and food additives in the step 5.
It is further preferred that the food thickening agent includes guar gum, xanthan gum, locust bean gum, konjac glucomannan, pectin, OK a karaoke club
At least one of glue, agar, gelatin, Arabic gum, the food additives include Aspartame, edible essence fragrance, red
At least one of sugar.
It is further preferred that the pill includes that common specification and big specification blood activating and fat reducing coronary dilatation expand blood vessel heart particle living,
Common specification blood activating and fat reducing coronary dilatation expands every 20~30mg of weight of blood vessel heart particle living, and big specification blood activating and fat reducing coronary dilatation expands the blood vessel heart living
Particle every is more than or equal to 50mg again.
In the present invention using peach kernel, safflower, rhizoma corydalis, Radix Salviae Miltiorrhizae, rhizoma cyperi, Rhizoma Chuanxiong, radix paeoniae rubra, Radix Angelicae Sinensis, Radix Rehmanniae, green peel, olibanum,
Ramulus cinnamomi, roud cardamon seed have promoting qi circulation and removing obstruction in the collateral, the effect of activating microcirculation and removing stasis medicinal after mentioned component compatibility synergy.
Peach kernel, bitter, sweet, flat have promoting blood circulation, relax bowel and defecation, relieving cough and asthma effect.
Safflower, acrid flavour is warm-natured, has the effect of blood circulation, removing blood stasis and acesodyne.
Rhizoma corydalis, pungent, bitter, temperature has the effect of promoting blood circulation, promoting the circulation of qi, analgesic.
The effect of Radix Salviae Miltiorrhizae, bitter is slightly cold, has promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle.
Rhizoma cyperi, pungent, slight bitter, micro- sweet and neutral have the effect of soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.
Rhizoma Chuanxiong, acrid flavour is warm-natured, has the effect of blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix paeoniae rubra, bitter, cold nature have the effect of clearing heat and cooling blood, removing blood stasis and acesodyne.
Radix Angelicae Sinensis, it is sweet, pungent, warm, it enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturizing dryness and lubricating intestine.The main all cards of the deficiency of blood；Irregular menstruation；Menostasis；Bitterly
Through；Abdominal mass knot is poly-；Metrorrhagia and metrostaxis；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness；Intestines are dry and shit is difficult；Weight after dysentery with bloody stool；Ulcer sores；Injury from falling down.
Radix Rehmanniae, it is sweet in flavor, it is cold in nature, there is the effect of clearing heat and cooling blood, benefiting yin are promoted the production of body fluid.
Green peel, it is bitter, pungent, it is warm-natured, there are soothing the liver relieving stagnant Qi, the stagnant effect of disperse accumulationization.
Olibanum, acrid flavour, hardship are warm-natured, have the effect of blood-activating and qi-promoting analgesic, detumescence and promoting granulation.
Ramulus cinnamomi, it is acrid flavour, sweet, it is warm-natured, there is the effect of sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi.
Roud cardamon seed, regulating the flow of QI to ease the stomach, dry cold-dampness, relieving alcoholism, the diseases such as abdominal distension for the treatment of for stomachache, gas gastric disorder causing nausea；
After mentioned component compatibility synergy, can the positive dampness elimination promoting the circulation of qi of temperature, the benefits of playing activating microcirculation and removing stasis medicinal, regulating qi and dredging collateral altogether.
The present invention by adopting the above technical scheme, compared with prior art, has the following technical effect that
Pathological characteristics of the present invention according to coronary heart disease, start with from activating microcirculation and removing stasis medicinal, regulating qi and dredging collateral, and full cloth selection Chinese herbal medicine is reasonable
Compatibility, and a kind of good drug efficacy is provided, the blood activating and fat reducing coronary dilatation of few side effects expands blood vessel heart particle living, can play reducing blood lipid, coronary dilatation,
The effect for expanding blood vessel, to alleviate patients with coronary heart disease clinical symptoms.
Specific embodiment
The present invention is described in more detail below by specific embodiment, for a better understanding of the present invention,
But following embodiments are not intended to limit the scope of the invention.
Embodiment 1
It includes 10 parts of rhizoma corydalis, 10 parts of peach kernel, safflower 10 that blood activating and fat reducing coronary dilatation of the present invention, which expands blood vessel heart particle living,
Part, 10 parts of Rhizoma Chuanxiong, 10 parts of radix paeoniae rubra, 15 parts of Radix Salviae Miltiorrhizae, 12 parts of Radix Angelicae Sinensis, 10 parts of Radix Rehmanniae, 10 parts of green peel, 10 parts of rhizoma cyperi, 3 parts of olibanum, osmanthus
10 parts, 3 parts of roud cardamon seed of branch.
Above-mentioned blood activating and fat reducing coronary dilatation expands the preparation method of blood vessel heart particle living, comprising the following steps:
Step 1, it according to formula rate, weighs the drug component other than roud cardamon seed and cleans, 20 times of volume of water is added to impregnate half
Hour, it is heated to slightly boiled, is kept for slightly boiled 1.5 hours, then roud cardamon seed is cleaned and is put into, then is kept for slightly boiled 0.5 hour, by the dregs of a decoction
Medical fluid is obtained by filtration；
Step 2, medical fluid is made in step 1 and is cooled to 60 DEG C, being concentrated under reduced pressure into specific gravity is 1.06；
Step 3, the material after step 2 concentration is spray-dried using spray dryer, the air inlet of spray dryer
Temperature is 160- DEG C, and leaving air temp is 95 DEG C；
Step 4, it collects spray powder after step 3 drying, spray powder be crushed into 80 meshes；
Step 5, spray powder obtained in step 4 is added into guar gum and Aspartame is prepared into the common of every weight 20mg
Specification pill.
Embodiment 2
It includes 15 parts of rhizoma corydalis, 15 parts of peach kernel, safflower 15 that blood activating and fat reducing coronary dilatation of the present invention, which expands blood vessel heart particle living,
Part, 15 parts of Rhizoma Chuanxiong, 15 parts of radix paeoniae rubra, 15 parts of Radix Salviae Miltiorrhizae, 18 parts of Radix Angelicae Sinensis, 15 parts of Radix Rehmanniae, 15 parts of green peel, 15 parts of rhizoma cyperi, 8 parts of olibanum, osmanthus
15 parts, 8 parts of roud cardamon seed of branch.
Above-mentioned blood activating and fat reducing coronary dilatation expands the preparation method of blood vessel heart particle living, comprising the following steps:
Step 1, it according to formula rate, weighs the drug component other than roud cardamon seed and cleans, 20 times of volume of water is added to impregnate half
Hour, it is heated to slightly boiled, is kept for slightly boiled 1.5 hours, then roud cardamon seed is cleaned and is put into, then is kept for slightly boiled 0.5 hour, by the dregs of a decoction
Medical fluid is obtained by filtration；
Step 2, medical fluid is made in step 1 and is cooled to 60 DEG C, being concentrated under reduced pressure into specific gravity is 1.06；
Step 3, the material after step 2 concentration is spray-dried using spray dryer, the air inlet of spray dryer
Temperature is 160- DEG C, and leaving air temp is 95 DEG C；
Step 4, it collects spray powder after step 3 drying, spray powder be crushed into 80 meshes；
Step 5, spray powder obtained in step 4 is added into guar gum and Aspartame is prepared into the common of every weight 20mg
Specification pill.
Embodiment 3
It includes 12.5 parts of rhizoma corydalis, 15 parts of peach kernel, safflower that blood activating and fat reducing coronary dilatation of the present invention, which expands blood vessel heart particle living,
12.5 parts, 12.5 parts of Rhizoma Chuanxiong, 10 parts of radix paeoniae rubra, 15 parts of Radix Salviae Miltiorrhizae, 12 parts of Radix Angelicae Sinensis, 15 parts of Radix Rehmanniae, 12.5 parts of green peel, 12.5 parts of rhizoma cyperi,
3 parts of olibanum, 12.5 parts of ramulus cinnamomi, 3 parts of roud cardamon seed.
Above-mentioned blood activating and fat reducing coronary dilatation expands the preparation method of blood vessel heart particle living, comprising the following steps:
Step 1, it according to formula rate, weighs the drug component other than roud cardamon seed and cleans, 20 times of volume of water is added to impregnate half
Hour, it is heated to slightly boiled, is kept for slightly boiled 1.5 hours, then roud cardamon seed is cleaned and is put into, then is kept for slightly boiled 0.5 hour, by the dregs of a decoction
Medical fluid is obtained by filtration；
Step 2, medical fluid is made in step 1 and is cooled to 60 DEG C, being concentrated under reduced pressure into specific gravity is 1.06；
Step 3, the material after step 2 concentration is spray-dried using spray dryer, the air inlet of spray dryer
Temperature is 160- DEG C, and leaving air temp is 95 DEG C；
Step 4, it collects spray powder after step 3 drying, spray powder be crushed into 80 meshes；
Step 5, spray powder obtained in step 4 is added into guar gum and Aspartame is prepared into the big rule of every weight 50mg
Lattice pill.
Embodiment 4
It includes 10 parts of rhizoma corydalis, 12 parts of peach kernel, safflower 15 that blood activating and fat reducing coronary dilatation of the present invention, which expands blood vessel heart particle living,
Part, 10 parts of Rhizoma Chuanxiong, 13 parts of radix paeoniae rubra, 15 parts of Radix Salviae Miltiorrhizae, 17 parts of Radix Angelicae Sinensis, 12 parts of Radix Rehmanniae, 10 parts of green peel, 13 parts of rhizoma cyperi, 5 parts of olibanum, osmanthus
10 parts, 5 parts of roud cardamon seed of branch.
Above-mentioned blood activating and fat reducing coronary dilatation expands the preparation method of blood vessel heart particle living, comprising the following steps:
Step 1, it according to formula rate, weighs the drug component other than roud cardamon seed and cleans, 20 times of volume of water is added to impregnate half
Hour, it is heated to slightly boiled, is kept for slightly boiled 1.5 hours, then roud cardamon seed is cleaned and is put into, then is kept for slightly boiled 0.5 hour, by the dregs of a decoction
Medical fluid is obtained by filtration；
Step 2, medical fluid is made in step 1 and is cooled to 60 DEG C, being concentrated under reduced pressure into specific gravity is 1.06；
Step 3, the material after step 2 concentration is spray-dried using spray dryer, the air inlet of spray dryer
Temperature is 160- DEG C, and leaving air temp is 95 DEG C；
Step 4, it collects spray powder after step 3 drying, spray powder be crushed into 80 meshes；
Step 5, spray powder obtained in step 4 is added into guar gum and Aspartame is prepared into the big rule of every weight 50mg
Lattice pill.
Specific embodiments of the present invention are described in detail above, but it is merely an example, the present invention is simultaneously unlimited
It is formed on particular embodiments described above.To those skilled in the art, any couple of present invention carries out equivalent modifications and
Substitution is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and
Modification, all should be contained within the scope of the invention.
Claims (9)
1. a kind of blood activating and fat reducing coronary dilatation expands blood vessel heart particle living, which is characterized in that according to parts by weight, including following components: prolong
10~15 parts of Hu rope, 10~15 parts of peach kernel, 10~15 parts of safflower, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of radix paeoniae rubra, Radix Salviae Miltiorrhizae 15~20
Part, 12~18 parts of Radix Angelicae Sinensis, 10~15 parts of Radix Rehmanniae, 10~15 parts of green peel, 10~15 parts of rhizoma cyperi, 3~8 parts of olibanum, ramulus cinnamomi 10~15
Part, 3~8 parts of roud cardamon seed.
2. blood activating and fat reducing coronary dilatation according to claim 1 expands blood vessel heart particle living, which is characterized in that according to parts by weight,
Including following components: 10~12 parts of rhizoma corydalis, 10~12 parts of peach kernel, 10~12 parts of safflower, 10~12 parts of Rhizoma Chuanxiong, radix paeoniae rubra 10~12
Part, 15~17 parts of Radix Salviae Miltiorrhizae, 12~14 parts of Radix Angelicae Sinensis, 10~12 parts of Radix Rehmanniae, 10~12 parts of green peel, 10~12 parts of rhizoma cyperi, olibanum 3~5
Part, 10~12 parts of ramulus cinnamomi, 3~5 parts of roud cardamon seed.
3. the preparation method that a kind of blood activating and fat reducing coronary dilatation as claimed in claim 1 or 2 expands blood vessel heart particle living, which is characterized in that
The following steps are included:
Step 1, it according to formula rate, weighs the drug component other than roud cardamon seed and cleans, 10~15 times of volume of water is added to impregnate half
Hour, it is heated to slightly boiled, is kept for slightly boiled 1.5 hours, then roud cardamon seed is cleaned and is put into, then is kept for slightly boiled 0.5~1 hour, it will
Medical fluid is obtained by filtration in the dregs of a decoction；
Step 2, medical fluid is made in step 1 and is cooled to 50~60 DEG C, being concentrated under reduced pressure into specific gravity is 1.06-1.08；
Step 3, the material after step 2 concentration is spray-dried using spray dryer, the inlet air temperature of spray dryer
It is 160~180 DEG C, leaving air temp is 95~105 DEG C；
Step 4, it collects spray powder after step 3 drying, spray powder be crushed into 60~150 meshes；
Step 5, spray powder obtained in step 4 is prepared into capsule, tablet, pill or oral solution.
4. blood activating and fat reducing coronary dilatation expands the preparation method of blood vessel heart particle living according to claim 3, which is characterized in that step 1
In, the additional amount of the water is 12~13 times of the drug component quality other than the roud cardamon seed；It is kept for slightly boiled 0.8~1 hour.
5. blood activating and fat reducing coronary dilatation expands the preparation method of blood vessel heart particle living according to claim 3, which is characterized in that step 2
In, the cooling temperature of the medical fluid is 55~57 DEG C；The concentration specific gravity is 1.07-1.08.
6. blood activating and fat reducing coronary dilatation expands the preparation method of blood vessel heart particle living according to claim 3, which is characterized in that step 3
In, the inlet air temperature of the spray dryer is 174~177 DEG C；Leaving air temp is 98~100 DEG C.
7. blood activating and fat reducing coronary dilatation as claimed in claim 3 expands the preparation method of blood vessel heart particle living, alternative in the step 5
Ground increases suitable food thickening agent and food additives.
8. blood activating and fat reducing coronary dilatation as claimed in claim 7 expands the preparation method of blood vessel heart particle living, the food thickening agent includes
At least one of guar gum, xanthan gum, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum, the food
Product additive includes at least one of Aspartame, edible essence fragrance, brown sugar.
9. blood activating and fat reducing coronary dilatation as claimed in claim 3 expands the preparation method of blood vessel heart particle living, the pill includes common rule
Lattice and big specification blood activating and fat reducing coronary dilatation expand blood vessel heart particle living, and it is every that the common specification blood activating and fat reducing coronary dilatation expands blood vessel heart particle living
20~30mg of weight, the big specification blood activating and fat reducing coronary dilatation expand blood vessel heart particle every living and are more than or equal to 50mg again.
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Application publication date: 20190517 |