CN109745347A - The composition of North America amaranth vitamin D and its enhancing immune response and the purposes for extending body half-life period - Google Patents
The composition of North America amaranth vitamin D and its enhancing immune response and the purposes for extending body half-life period Download PDFInfo
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Abstract
The invention discloses a kind of compositions, it includes North America amaranth and vitamin D or derivatives thereof.The present invention also provides a kind of anti-inflammatory food, health food or drugs, it is using composition above-mentioned as active constituent, in addition the preparation that pharmaceutically acceptable auxiliary material or complementary ingredient are prepared.Inflammation can be effectively relieved in the present composition, can treat benign prostate inflammation, and application prospect is good.
Description
Technical field
The present invention relates to drug natural medicine field, one kind includes North America amaranth and vitamin D.
Background technique
The common a member of North America Amaranthus in Amaranthus, can be grown in the most area of America & Canada,
Europe and the other areas in the world can also be grown in.
North America amaranth has been used a very long time, usually occurs at present with the product form of tea, can be used for delaying
Solve it is various do not accommodated as caused by inflammation disease or it is relevant to inflammatory process do not accommodate disease, for example, by benign prostate
Various symptoms caused by hyperplasia disease (BPH), urogenital tract or hemorrhoid infection etc..
The various preparations of North America amaranth, especially dry medicinal tea is very popular on European market, fewer in other areas
See.In Europe, it is primarily used to alleviate benign prostatic hyperplasis (BPH), moreover, its good effect has obtained market
It is widely recognized as.Meanwhile the medical application of the plant also has passed through systematic research confirmation, for example, Bogdan Boskovic,
" pharmacology-toxicity of Amer tea-clinical expert report ";National poison control center, Belgrade, in Serbia (2005)
Describe the related efficacy of North America amaranth.Disease and its other medicinal functions are treated about Amaranthus is used in this document
Have recorded.
However, the preparation that aforementioned North America amaranth is used alone, acts on not fully the healing of clinical symptoms.Usual situation
Under, using this preparation cannot as desired by user and care-giver complete incidence graph symptom, discomfort or cure potential disease.
Summary of the invention
To solve the above-mentioned problems, more efficiently to release we provide a kind of composition comprising North America amaranth
Tea-drinking, for alleviating benign prostatic hyperplasis (BPH), prostatitis, women prostate occlusive syndrome, urogenital infections
With various discomforts caused by hemorrhoid, thus achieve the effect that cure these diseases.
Content of the invention
For the explanation of the present invention and its not limited embodiment in each project number text section below
It is illustratively illustrated in falling.The phrase arrived used in paragraph is illustrated in the text of these project numbers: " according to above-mentioned
Or any one of following " refer to content in sundry item number text paragraph in the part.In these text paragraphs, this
Phrase has explicitly indicated that the illustrative embodiment in this document contains the content in each project number text paragraph,
Simultaneously also comprising any combination with the subject content in any one or more sundry items number.The purpose of applicant be
Both can be with individualism in being explicitly described the contents of these project numbers, it can also any combination each other.It wherein also include appointing
Listed alternative solution and any combination between them in what project.Therefore, it has been wrapped in the embodiment published
Main contents, alternative solution containing each noncontinuous item, and with the combined application form of any other item subject (including its
Middle illustrated alternative).Applicant retains special for involved any in the statement of these project text paragraphs
The claim of subject content, including the alternative of independent, various or various combining forms.
The present invention provides a kind of pharmaceutical compositions, it includes North America amaranth and vitamin D or derivatives thereof.
Wherein, the North America amaranth is Amaranthus amaranthaceous plant North America amaranth Amaranthus blitoides S.Watson.
Wherein, the North America amaranth is the dried leaf of North America amaranth.Preferably, wherein the U.S. amaranth is North America amaranth dried leaf
Full leaf, fragment or powder or the mixture that they are mixed with arbitrary proportion.
Wherein, the vitamin D is vitamine D1, calciferol, vitamine D3, vitamine D4, Vitamin D5 or dimension life
Plain D6.
Wherein, in the composition, the ratio of North America amaranth and vitamin D is 1g:(1~350) IU, preferably 1g:1,2,
3,4.5.10,15,20,25,30,40,50,60,75,100,125,150,175,200,225 250,275,300,325 or
350IU。
Wherein, in the composition, the ratio of North America amaranth and vitamin D is 1g:(1-2000) IU, 2g:100IU or
5g:400IU.
Wherein, minerals, organic matter, vitamin, amino acid or the battalion eaten suitable for the mankind are also contained in the composition
Support substance.
Wherein, the composition includes following any one or more of substance: such as: zinc, copper, iodine, chromium, iron, molybdenum, selenium, silicon,
Boron, vanadium, germanium, potassium, calcium, phenol, sterol, free fatty acid;Vitamin C, vitamin E, vitamin B-6 and other vitamins rely ammonia
Acid, glycine and tyrosine;Sea-buckthorn, lycopene, Quercetin, African pea pierce nettle, pumpkin seed oil, chinaroot greenbrier, ginseng, cream
Ji, kelp, pollen, linseed, beeswax, glycine.
The present invention also provides a kind of food, health food or drug, it be with the bulk pharmaceutical chemicals of composition above-mentioned, or
Using its water, perhaps extractive with organic solvent is active constituent plus pharmaceutically acceptable auxiliary material or the preparation of complementary ingredient to person
Made of preparation.
Wherein, the preparation is oral preparation.
Wherein,said preparation is oral preparations.
Wherein, the food is infant foods;And/or the food is candy, bread, cake, biscuit.
Wherein, the preparation is energy drink, tea, coffee, lemonade, fruit juice, fruit drink, soft drink, water, seasoning water
Beverage or nutritious drink.
Wherein, the preparation is medicinal tea, capsule, powder, decoction, granule, tablet, capsule, oral solution, pill.
Wherein, in the capsule or tablet, the ratio of North America amaranth and vitamin D is 0.6718g:400IU.
Wherein, in the capsule or tablet, in every 1 capsule, the weight of North America amaranth is 0.6718g, and vitamin D is
400IU。
Wherein, in every 1 capsule or tablet, contain 0.1,0.2,0.5,1.0,2.0,3.0,4.0,5.0,7.0,10,
15,20,25,50,100,150,200,250 or 500 grams of North America amaranths.
Wherein, the auxiliary material is filler, preservative, colorant, sweetener or the flavoring agent eaten suitable for the mankind.
The present invention also provides a kind of preparation methods for preparing aforementioned food, health food or drug, and steps are as follows: taking
The raw material of North America amaranth in composition above-mentioned, or progress water mentions or organic solvent extracts, and is added, vitamin D or its derivative
Object adds pharmaceutically acceptable auxiliary material or complementary ingredient.
The present invention also provides a kind of health beverages, it includes water penetration container and composition above-mentioned, the combination
Object is placed in water penetration container.
The aforementioned health beverages of the present invention, adopt and drink after being soaked in water.
Wherein, in the health beverages, the ratio of North America amaranth and vitamin D is 2g:100IU or 5g:400IU.
Wherein, contain 0.1,0.2,0.5,1.0,2.0,3.0,4.0,5.0,7.0,10,15,20 in every 1 health beverages,
25,50,100,150,200,250 or 500 grams of North America amaranths.
Wherein, the water penetration container is the tea bag of tea bag.
The present invention also provides a kind of methods of aforementioned health beverages, it is characterised in that: steps are as follows: taking combination above-mentioned
Object is packed into water penetration container, sealing.
The present invention also provides composition above-mentioned, food above-mentioned, health food or drugs, health beverages above-mentioned
Purposes in the food of preparation treatment or adjuvant treatment inflammation, health food or drug.
The present invention also provides composition above-mentioned, food above-mentioned, health food or drugs, health beverages above-mentioned
In preparation treatment or adjuvant treatment arthritis, benign prostatic hyperplasis, women prostate occlusive syndrome, urogenital tract sense
Preferably, the arthritis is rheumatoid joint to purposes in the food of dye and/or hemorrhoid inflammation, health food or drug
It is scorching.
The present invention also provides composition above-mentioned, food above-mentioned, health food or drugs, health beverages above-mentioned
Improving the purposes in immunity of organisms and/or the food, health food or drug that activate vitamin D receptor.
The present invention also provides compositions above-mentioned, aforementioned food, health food or the drug, health care above-mentioned
Purposes of the drink in the food, health food or drug in preparation treatment metabolic syndrome.
The present invention also provides the bulk pharmaceutical chemicals of composition above-mentioned to prepare the purposes in animal feed.
In the present composition, North America Amaranthus is not belonging to grain in straw or like vegetable, and North America amaranth itself can resist disease pest
Evil, does not need to spray insecticide, therefore the present composition is prepared into animal feed, can overcome existing grain prepare and
At feed various defects, for example, there is pesticide, it is not easy to digestion etc..
Present invention firstly discovers that North America amaranth contains vitamine D3, after testing, in the amaranth of North America, the content of vitamine D3 is less than
The content of 0.0200IU/g, calciferol are less than 0.0800IU/g.
Vitamin, especially vitamine D3 is added in the present invention in the amaranth of North America, and immunity of organisms, activation dimension life can be improved
Plain D receptor alleviates verifying, treatment of arthritis, benign prostatic hyperplasis, women prostate occlusive syndrome, urogenital tract sense
Dye and/or hemorrhoid inflammation.
Extend half-life period and defence
Inflammatory effect 50% or more population in the world, is such as prostate the main reason for leading to many disease types
Inflammation and rheumatoid arthritis.In the present invention, vitamine D3 intrinsic in the amaranth of North America can extend half-life period (keeping it longer)
It ensure that the validity and feasibility of North America amaranth and its extract for treatment.The extension of half-life period ensures North America amaranth and its mentions
It takes object to promote the activation of mankind's vitamin D receptor (VDR), and then swelling and inflammation can be reduced, necessary protection is provided, control
Inflammation is horizontal in body acceptable, and control inflammation the generation increased with other inflammation related diseases.The vitamin D meeting of activation
In conjunction with vitamin D receptor, regulate and control the responsive transcription of body, in body, regulation of the vitamin D receptor by VDR gene.
It is worth further, it is emphasized that North America amaranth and its extract, which are added in drug, can extend its validity.We
It is believed that extending intrinsic substance in North America amaranth or its extract by our work (vitamin D is added in the amaranth of North America)
The effect of (vitamine D3), it can be ensured that when treating inflammation and its related disease, lasting dosage is capable of providing, to generate product
Polar region, lasting curative effect.
Inflammation can be effectively relieved in the present composition, have benign prostate inflammation to have definite curative effect, and application prospect is good.
International unit used in this document (IU) is the metering list for referring to various forms of vitamin Ds and its derivative
Position.As described below, international unit used is measurement unit of equal value for replacing 65 picomoles in this document.
When referring to vitamine D3, i.e. (3 β, 5Z, 7E) -9,10- open loop cholesteric -5,7,10 (19)-triolefin -3- alcohol, vitamin
D3 is also referred to as the 7-DHC of Vitamin D3 and activation.When an international unit (IU) refers to 0.025 microgram, due to
The molecular weight of vitamine D3 is 384.64g/mol, and the vitamine D3 of an international unit (IU) is equal to pure (the 3 of 65 picomoles
β, 5Z, 7E) -9,10- open loop cholesteric -5,7,10 (19)-triolefin -3.Common recognition herein is that the quality of 65 picomole substances will depend on
In the size of its molecular weight.For the different molecular weight of substance, the quality of picomole substance will also change therewith.Equally,
" activity " (such as vitamin D activities measurement) in given measurement, such as the substance (such as 65 picomoles) of specified rate, in measurement
" activity " then will depend on substance catalytic activity.If the substance is in completely pure active form, " activity "
Also the intrinsic activity of the substance will be depended on.To avoid reader from generating any ambiguity to these concepts, illustrate hereby, a world
The vitamin D of unit (IU) and the substance equivalent of 65 picomoles.For example, being added to 100 worlds in the U.S., in every glass of milk
The vitamin D of unit (IU);That is the content of vitamin D is about 2.5 micrograms in every glass of milk.
Term used in this document be " North America amaranthOne gram equivalent "Refer to one gram of cured leaf of North America amaranth, or by one gram
Any extract, derivative and liquid made of cured leaf.For example, the amount of liquid obtained by impregnating one gram equivalent of North America amaranth
It is equal to the retrievable amount of liquid from every gram of cured leaf.Such as 25 grams of cured leafs are immersed in 250 milliliters of water, in every 10 milliliters of water
Understand the Amaranthus containing one gram equivalent.If identical liquid is concentrated into 50ml, meeting in every 2 milliliters of water from 250ml
Contain one gram equivalent of Amaranthus.
It is previously mentioned in this documentContainerThis term refers to sack or object similar with sack, especially this place
The water penetration container stated.This container allows them to be contacted with liquid while storing North America amaranth composition, with rear
It also can be convenient for users to being drawn off.This is roughly the same as the Sheng concept of tea container with using tea bag, i.e., user can be very convenient
Used tea bag is placed or taken out into hot water in ground.
Composition described in this document can be used to alleviate the related symptoms and discomfort caused by inflammation.For example, scorching
Disease property disease, benign prostatic hyperplasis, women prostate occlusive syndrome, urogenital infections and hemorrhoid etc..It can also quilt
For treating associated disease, their application method is hereinafter also listed.
North America amaranth
Amaranthus blitoides
North America amaranth is to be under the jurisdiction of the edible herbaceous plant of one of Amaranthus.Many countries of this plant in Europe are outstanding
To be common, including, Germany, France, Italy, Croatia, Studenica Monastery republic.It is being up to several centuries
Time in, it is used as the food of the mankind and domestic animal.Also never there is any significant side effect in period.In the U.S., it
Occur on the market, being often made into flour usually in the form of various health care products and organic food, bread, pasta and other
Bakery.In addition, being free of seitan in three-coloured amaranth.
Similar all Amaranthus, it also has male and the instaminate flower of separation.Male flower usually has 4 to 5 valve calyxs
Piece, 3 stamens, and there is no petal.Instaminate flower usually has 4 to 5 sepals, and does not have petal.The sepal of male flower and female flower is equal
For long round shape lanceolar, it is about 1/8 inch.
North America amaranth is typically considered to originate from the middle part or eastern region in the U.S. earliest.Nowadays, people can be in gas
Mild North America is waited, wild North America amaranth is seen in South America and Eurasia.It usually summer grow, like it is sunny and
The soil in moist and fertile area.It is the plant by anemophily, and plant can usually grow into 0.6 to 1 meter.North America amaranth
Flower gather around the column cap there are three axillary form, the tip portion and flower itself of petal are equally long.Every flower can generate a capsule,
Each capsule can discharge a seed again, seed be it is edible, appearance is shinny dark-brown or black, and it is rounded and
Flat disk, about 1.1 to 1.7 millimeters of diameter.It is cultivated, harvest, dry and preparation process are known to market, meanwhile,
On market today, it often occurs with several different business forms.
It is such as to calculate basis with weight percent, the content of protein is higher than the content in milk in the amaranth of North America, moreover,
Fiber content is more three times higher than wheat, and iron content is five times higher than wheat.Meanwhile it also has a vitamin A of high level, C, calcium, potassium
And phosphorus.Quite high-caliber lysine contained in the amaranth seed of North America is also exactly the element lacked in other cereal.The plant
Object also contains a large amount of macroscopic view and micronutrient, for example, vitamin C, carrotene, starch, protein, fat oil, sugar are fine
Dimension element, flavonoids, tannic acid, glycine betaine, saponin, glycoprotein, Sitosterolum, TRF, iron, manganese, copper, cobalt, potassium, zinc and sodium etc..Together
When, it is also the important sources for refining rape oil and stigmasterol.For a long time, which all has analgesia, anti-inflammatory and spasmolysis with it
Pharmacological property and it is famous, unquestionably, mentioned component plays the role of vital wherein.For example, flavone compound with
Free radical combines, and can achieve anti-inflammatory, antibacterial and antiviral effect.Saponin(e then has unique anti-inflammatory effect.It is rich in
Protein and glycoprotein the effect of being considered to have good antibacterial and antioedematous.Sitosterolum is that one kind can pass through interference
Prostaglandin metabolism and the phytosterol for reaching anti-inflammatory effect, meanwhile, it has been reported and shows that Sitosterolum has anti-benign prostate
The effectiveness of hyperplasia (BPH).In addition, the plant steroid of two kinds of entitled campesterols and stigmasterol is also found in the plant extracts
Alcohol.According to records, both elements can help to improve cholesterol level.Meanwhile they are for peripheral arterial lesion and coronal dynamic
The symptom of arteries and veins disease can also play certain relaxation effect.
In one embodiment, the leaf of North America amaranth is dried.And in another arrangement, leaf be with
Other modes are chopped into, and are crushed, powdered or decomposition.Its leaf may be alternatively used for preparing any one or more of liquid medicine
Product, for example, tea, tincture, prepare the concentrated extract of beverage.Including healthy beverage, nutritional supplement drinks and sports drink
Deng.Meanwhile can also be used to process various formulas, for example, solid dispersions, liquid dispersion, capsule, tablet etc..
Vitamin D
Vitamin D
Vitamin D is a kind of necessary nutrient in Human physiology.Most important influence is played for human nutrition
Two kinds of vitamins are respectively calciferol (ergocalciferol) and vitamine D3 (Vitamin D3).The vitamin D of other forms is also
Including vitamine D1 (product that calciferol and lumisterol are mixed with the ratio of 1:1), vitamine D4 (ergocalciferol) and
Vitamin D5 (calciferol).Calciferol and D3 are the precursors of physiologically active compound.The two is all by two hydroxyls
Addition reaction and generate activation.First addition reaction typically occurs in inside liver, and second addition reaction usually occurs
Inside kidney or among the cell of immune system.And the reaction carried out in the latter usually will cause the vitamin after activation
Generate cytokine activity variation.
Vitamine D3 after activated combines generated compound (D-VDR) with its receptor, then with retinoid receptor
(RXR) it combining and forms heterodimer, this heterodimer combines in its sensitive regulatory region with vitamine D3 response factor again,
Both combination can be realized the transcription variation of gene, the effect of transcription variation is not only limited by heterodimer and gene
In conjunction with, also simultaneously influenced by a series of common activator.Including CBP/SRC co-activating factor coniplexes and vitamin
The albumen composition (DRIP) of D acceptor interaction, through RAS activation ETS transcription factor and SWI/SNF compound and
The member of CCAAT enhancing binding protein family.Vitamine D3 responsive genes, usually to participating in calcium and phosphate transport and albumen
The encoding regulator of matter.Especially to the protein coding of transport protein, wherein again especially significant with TRPV6 and calbindin.
Molecular biology reflects major physiological activity of the vitamin D in terms of the proper level for adjusting calcium phosphorus, especially
It is adjusted by their absorption activities in enteron aisle.These activities sufficiently explain due to being deficient in vitamin D and cause
Pathologic, physiologic effect: bone mineralising obstacle, and due to children's osteomalacia caused by the loss of calcium during osteomalacia, at
People's bone malacosis, and adult hyperparathyroidism.
In the world in the more flourishing country of economy, this phenomenon of vitamin D deficiency is forced essentially by government
This mode of vitamin D is added in certain foods and is prevented.For example, prevention is by adding in every glass of milk in the U.S.
Add the vitamin D of 100 international units (IU) " contain " and realizes.However, internal evidence suggests, many American Womens
Still lack enough vitamin Ds.It can be seen that there is still a need for continue the supplementary quota in diet for they for these crowds
Outer vitamin D.(referring to Christakos et al.(2003), J.Cellular Biochem.88:695-705;
Christakos et al.(2006), Ann.NYAcad.Sci.106:194-203;Christakos et al.(2007)
Ann, NYAcad.Sci.1116:340-348 and National Report on Biochemical Indicators of
Diet and Nutrition in the US Population (1999-2002), Fat Soluble Vitamins&
Nutrients:Vitamin D;The 61-69 pages).In addition, lacking on market today some for can not normal stool dairy produce
The meal supplement source that eats of crowd, and the present invention contains the birth of the North America amaranth product of abundant vitamine D3, just may be used
Needed for life to meet such crowd.
It has been investigated that vitamine D3 plays important role during immunological regulation, and can participate in certain
In the process for resisting cancer.It is also demonstrated to for inhibiting cell Proliferation, and point of a plurality of types of tumour cells of promotion
Change.Including prostate cancer cell line and primary prostate tumor cells system.Meanwhile it can also be helped outside opposed body
(Song waits (200X) .1,25- dihydroxyvitamin D3 that can help to reduce human prostate cancer cells for the invasion of prostate gland cancer cell
Adherency and migratory movement (Stanford University Medical institute, endocrine, gerontology and metabolism).In addition, vitamin D energy
Enough inductions reduce the expression quantity of α 6 and 4 integrator gene of β, this is exactly migrated with the increase of prostate gland cancer cell in vitro and invasion
Relevant (Song waits (2000) cellular elements endocrinology, 164:133-143).In addition, the experiment proved that, vitamine D3 class
Like object, i.e. BXL-628, prostatic growth can be prevented, to reduce the prostate in the 5th stage of clinical test IIa phase
Volume (Colli waits (2006), European urology, 49:82-86).Also reference can be made to WO2005/027923: using vitamine D3
Analogue treatment hyperplasia of prostate.
The source of vitamin D compounds
It is suitable for the diversified forms that the mankind eat as described in every related invention in this document, present on market today
Vitamin D can individually or synthesis by way of obtain.Including vitamine D1, calciferol, vitamine D3,
The separate constituent or composition of vitamine D4 or Vitamin D5.
For example, vitamine D3 can be sold on the market in the form of different soluble formulations, this in the application
It is identical of views in the various embodiments being previously mentioned.Wherein, Falcon International Trade Corporation mainly sells vitamine D3 gallbladder calcium
Change alcohol;It is soluble white crystalline powder, and fusing point reaches 82-87 DEG C;Absorbance is 0.46-0.50;Optical activity is+105-+
112°;Activity is 38,800,000-41,200,000IU/g (97.0-75.0) 103.0% purity);7-DHC <
0.2%.LycoRed company also provides a series of Vitamin D preparation that suitable mankind eat to market.One of which is powder
The preparation of form, the vitamin D in said preparation can be used to process dietary supplements, often in the form of tablet and hard-shell capsule
Occur.The preparation containing calciferol and D3 of the type has following given activity: calciferol 100,000 and 850,
000IU/g;Vitamine D3 100,000,500,000 and 1,000,000IU/g.Can be used for of especially preparing, is also sold by the said firm
The microencapsulated powder of food and beverage adding ingredient, including calciferol 100E (100,000IU/g) and vitamine D3 100E
(100,000IU/g).Meanwhile the said firm also provides the cold water-dispersible powder preparation that can be used for food and beverage adding ingredient,
Including calciferol 100CWD (100,000IU/g) and vitamine D3 100CWD (100,000IU/g).The said firm also can be to visitor
Family provides the oil suspension for being suitable for processing soft gel capsule, including contains 1,000,000IU/g calciferol and 1, and 000,
The preparation of the vitamine D3 of 000IU/g.
These preparations can be used in the various embodiments of invention described in this document.
These and other such formulations may be used in accordance with
various embodiments of the inventions herein described.
The metabolism of vitamin D and dosage
Metabolism and Dosage of Vitamin D
Health adult is very wide in range for the tolerance range of vitamin D dosage;But in being excessively used and also causing
Poison.Such as daily using the dosage of about 1250 μ g or more, toxicity can be presented in normal adults in vivo.It is daily continuous in two weeks
Take in the vitamin D of 375 μ g/kg (90lb people about 15mg), it will usually cause to generate acute toxicity in adult body.Connect daily for a long time
Continue the vitamin D (for 90lb people about 1mg) of 25 μ g/kg of intake, toxicity can also be presented in adult human body.If user suffers from
Certain diseases, body can also correspondingly improve the sensibility of vitamin D.In certain extreme cases, it even slightly mentions
The vitamin D level risen may also lead to human body and suffer from adult hypercalcinemia.Pregnant woman is such as diagnosed with hypercalcinemia, then may be used
Foetus can be caused to suffer from the illnesss such as congenital baryencephalia and facial deformity.Referring to Remington:The Science
and Practice of Pharmacy 21th Ed., P.Beringer, pps 1696-1697, Lippincott,
Williams&Wilkins, Baltimore, MD (2006).
The composition of North America amaranth-vitamin D of the present invention
It is referred to the methods for obtaining North America amaranth and vitamin D in certain embodiments: 1) obtaining in a usual manner;2)
It is obtained from commercial supplier.In addition, vitamin D can also be configured to it is water-soluble, and together with the amaranth composition of North America by with
In preparation various types of beverages (for example, tea-drinking).In certain embodiments, it can be seen that the composition of North America amaranth and vitamin D exists
Preserved material or tea bag are prepared in container by immersion way.
In certain embodiments, related North America amaranth is under the jurisdiction of S.Watson class Amaranthus.
In certain embodiments, the effective vitamin D product provided to subject, its essence is by vitamine D1,
Calciferol, vitamine D3, vitamine D4 or a variety of are formed one of Vitamin D5 or derivatives thereof.
In certain embodiments, North America amaranth is crushed with being chopped into, powdered or above-mentioned any one or more of mixture
Form occur.
In certain embodiments, North America amaranth shreds leaf, the form appearance of crushed leaves or powder leaf with full leaf.Meanwhile
It can be mixed by above-mentioned various modes.
In certain embodiments, the ratio of vitamin D and North America amaranth is about are as follows: containing from 1,2,3 in every gram of North America amaranth,
4.5,10,15,25,30,40,50,60,75,100,125,150,175,200,225,250,275,300,325 to 350 states
The vitamin D of border unit (IU) inequality.
In certain embodiments, the ratio of vitamin D and North America amaranth is about within the scope of following: containing in every gram of North America amaranth
Have from 1-2,000,2-2,000,5-1,000,5-500,10-10,000,1-10,500,1-15,000,20-500,50-1,
000,50-500,50-250,50-125,25-250,25-750,75-750,75-500,75-225,0.1-100,0.5-50,
The vitamin D of 0.25-25,1-25,1-15 to 1-10 international unit (IU) inequality.
In certain embodiments, composition also includes other substances eaten suitable for the mankind.
In certain embodiments, composition also includes any one or more of following substance of certain amount and combination:
Filler, preservative, colorant, sweetener or the flavoring agent eaten suitable for the mankind.
In certain embodiments, composition also includes a certain or various other metals, for example, minerals, organic matter,
Vitamin, amino acid and other substances, and the nutriment eaten suitable for the mankind.In certain embodiments, the combination
Object include following any one or more of element: such as: zinc, copper, iodine, chromium, iron, molybdenum, selenium, silicon, boron, vanadium, germanium, potassium, calcium and/it is more
Phenol, sterol (such as sitosterol), free fatty acid;Vitamin C, vitamin E, vitamin B-6 and other vitamins;Lysine,
Glycine and tyrosine;Sea-buckthorn, lycopene, Quercetin, African pea, thorn nettle, pumpkin seed oil, chinaroot greenbrier, ginseng, milk thistle,
Kelp, pollen, linseed, beeswax, glycine.
In certain embodiments, composition is formulated with ratio described in this document added with vitamin D
North America amaranth extract, tincture or other liquid.It is also possible to further add any one or more of group of mentioned component
Synthesis point.For example, thickener, filler, preservative, colorant, sweetener or flavoring agent.In embodiments, extract is
It is used to prepare tea-drinking, the concentrated extract of sports drink or Other Drinks.
In certain embodiments, composition is adapted for the beverage that the mankind drink.For example, tea-drinking, sports drink, energy drink
Material, lemonade, fruit juice or fruit drink, soft drink season water drinks or nutritious drink.Concentration is added in these beverages
North America amaranth and vitamin d compositions, other compositions described above also or optionally.
In certain embodiments, composition is placed on the capsule eaten suitable for the mankind, caplet, tablet or other are solid
In body preparation.In certain schemes, these compositions are stored in water penetration container, for example, the container for making tea.Another
In some schemes, composition is then stored in the container made of following any one or more of material: filter paper, nylon or silk
Silk fabric.
Embodiment, provides a kind of water penetration container, the ingredient specific gravity of storable composition is about 0.1,0.2,
0.5,1.0,2.0,3.0,4.0,5.0,7.0,10,15,20,25,50,100,150,200,250 or 500 gram.
The ingredient ratio of a kind of water penetration container, storable composition weighs about within the scope of following: 0.1-100,
0.5-500,0.5-25,1-5,1-10,1-10,000,2-10,4,2-20,2-200,15-150,25-750 or 50-5,000 gram.
Caplet, tablet or other solid pharmaceutical preparations are also provided in embodiment, wherein composition as described above contains
Amount about are as follows: 0.1,0.2,0.5,1.0,2.0,3.0,4.0,5.0,7.0,10,15,20,25,50,100,150,200,250 or
500 grams.
The capsule eaten suitable for the mankind, caplet, tablet or other solid pharmaceutical preparations are additionally provided in embodiment.Wherein as above
The content of composition described in text is about 0.1-0.5,0.2-1.0,0.5-2.0,1.0-3.0,2.0-4.0,3.0-5.0,2.5-
7.5,5.0-10,7.5-15,10-20,15-30,25-50,30-60,50-100,75-125,100-150,125-175,150-
200,175-250,200-300,250-500 grams or more.
Effect
The composition of North America amaranth as described herein and vitamin D can be used for mitigation and inflammation, arthritis, benign prostate
Hyperplasia (BPH), women prostate occlusive syndrome, sense of discomfort caused by urogenital infections or hemorrhoid etc..In embodiment
The therapeutic modality referred to will not cause unnecessary sex dysfunction.
The composition of North America amaranth as described herein and vitamin D can be used for treating inflammation, arthritis, and benign prostate increases
Raw (BPH), women prostate occlusive syndrome, urogenital infections or hemorrhoid.The therapeutic modality referred in embodiment is not
It can cause unnecessary sex dysfunction.
Embodiment, provides for treating by inflammation, arthritis, benign prostatic hyperplasis (BPH), prostate, women
The method of one or more symptoms or hemorrhoid caused by prostate occlusive syndrome, urogenital infections and inflammation.Wherein wrap
It includes to subject in need and the composition of North America amaranth and vitamin D as described herein is provided.
Embodiment is also provided for treating the side with one or more malaise symptoms caused by immune-related disease
Method.The composition of North America amaranth and vitamin D as described herein is provided including to subject in need.
Embodiment is provided for treating inflammation, benign prostatic hyperplasis (BPH), women prostate occlusive syndrome,
The method of any one or more of urogenital infections or hemorrhoidal diseases.It is provided such as including to subject in need
The composition of North America amaranth and vitamin D as described herein.
Embodiment, provides a kind of with immune-related disorders methods for treating, including to it is in need by
Examination person provides the composition of North America amaranth and vitamin D as described herein.
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
Certain purposes of case study on implementation provided below North America amaranth only for the purpose of illustration and vitamin combination.Value
It must illustrate, purposes is not limited merely to these schemes recited herein.In order to more comprehensively be fully understood from this paper institute
These case study on implementation stated, reader is firstly the need of the full content of this application material is read over, secondly, needing to have certain
Professional knowledge relevant to the field.
Embodiment 1: the preparation of North America amaranth
The leaf of North America amaranth plant (North America Amaranthaceae Amaranthus Amaranthus blitoides S.Watson amaranth) is taken, is dried, pressure
Broken or chopping.
Embodiment 2: the preparation of the composition of North America amaranth and vitamin D
Take two kilograms of embodiments 1 prepare crushing North America amaranth leaf, then with one gramD3100E(100,
000IU/g) mix, whereinD3 100E is a kind of microencapsulation vitamine D3 powder system in food
Agent.
Final composition obtained includes the vitamin D and 2 grams of North America amaranth leaves of 100IU (1 milligram).
The preparation of North America amaranth tea bag of the embodiment 3 rich in vitamin D
According to the standard practices for being used to prepare the tea bag drunk suitable for the mankind, final composition prepared by embodiment 2
(including 1 milligram of vitamine D3 and 2 grams of North America amaranth leaves) is added in each tea bag packet.
Thus each tea-bag prepared includes the vitamine D3 system of 2 grams of dry North America amaranth leaves and 1 milligram of microencapsulation
Agent.
Vitamin d3 levels in every packet tea-bag reach 100IU, with the dimension added in one glass of milk selling in the U.S.
The content of raw element D3 is roughly the same.
The preparation of North America amaranth tea-drinking of the embodiment 4 rich in vitamin D
The North America amaranth tea bag that vitamine D3 is rich in described in embodiment 3 is impregnated about 5 points in one glass of boiled water (8 ounces)
Clock obtains the North America amaranth tea-drinking for being rich in vitamine D3.
The preparation of the concentration sports drink of embodiment 5
According to method described in embodiment 4 North America amaranth tea-drinking is prepared, by being evaporated in vacuo or freezing and evaporating (freeze-drying)
Tea-drinking is concentrated 100 times by mode.Gained concentrate is added in the preparation of sports drink with the ratio of 1:99 again, just can be obtained
To the North America amaranth sports drink for being rich in vitamine D3.
Alternatively, before mixing North America amaranth with vitamine D3, concentrating agents is first refined from the amaranth of North America, then by amount to concentration
Vitamine D3 is added in agent, is finally added among sports drink preparation or sports drink step by step.
The preparation of 6 capsule of embodiment
In order to produce capsule, the drying and crushing leaf of North America amaranth is mixed with vitamine D3 powder and is put into pharmaceutically acceptable
Capsule in.
In every 1 capsule, the weight of North America amaranth is 0.6718g, and the weight of vitamine D3 powder is 0.012mg (400IU).
The preparation of North America amaranth tea bag of the embodiment 7 rich in vitamin D
According to the standard practices for being used to prepare the tea bag drunk suitable for the mankind, the North America amaranth of crushing prepared by embodiment 1
Leaf and vitamine D3 are added in each tea bag packet.
Thus each tea-bag prepared includes 5 grams of dry North America amaranth leaves and 0.012 milligram of (400IUs) vitamine D3
Preparation.
Beneficial effects of the present invention are proved with the mode of experimental example below:
The treatment of the symptom relevant to inflammation of experimental example 1
Prepare tea-drinking according to the method for embodiment 4, allow with inflammation-related condition (including colon, rectal prostatic cancer
With the inflammation in joint) subject (100) daily absorb, the volume of tea-drinking is 8 ounces every time, daily absorb 2~5 times, should
Process continues at least two weeks.
After two weeks terminate, the inflammatory symptom of subject is alleviated.
Experimental example 2 treats symptom relevant to inflammation
With the daily ingestion of North America amaranth vitamine D3 capsule of subject relevant to inflammation (100) (such as institute in embodiment 6
State capsule), 2 capsules are taken in every time, and daily 3~5 times, which continues at least two weeks.
After two weeks terminate, the inflammatory symptom of subject is alleviated.
Experimental example 3 treats symptom relevant to benign prostatic hyperplasis (BPH)
Prepare tea-drinking according to the method for embodiment 4, allow with inflammation-related condition (including colon, rectal prostatic cancer
With the inflammation in joint) subject (100) daily absorb, the volume of tea-drinking is 8 ounces, daily absorb 2~5 times, the process
Continue at least two weeks.
After two weeks terminate, the partial symptoms (mainly inflammation) of subject are alleviated.
Experimental example 4 treats symptom relevant to benign prostatic hyperplasis (BPH)
The daily ingestion of amaranth vitamine D3 of the North America twice capsule of subject (100) with benign prostate scorching (BPH) is (such as
Capsule described in embodiment 6), 2 capsules are taken in every time, and daily 3~5 times, which continues at least two weeks.
After two weeks terminate, the partial symptoms (mainly inflammation) of subject are alleviated.
Inflammation can be effectively relieved in the results show, the present composition, can treat benign prostate inflammation, before
Scape is good.
Claims (28)
1. a kind of composition, it is characterised in that: it includes North America amaranth and vitamin D or derivatives thereof.
2. composition according to claim 1, it is characterised in that: the North America amaranth is Amaranthus North America amaranth
Amaranthus blitoides S.Watson。
3. composition according to claim 1 or 2, it is characterised in that: the North America amaranth is the dried leaf of North America amaranth, preferably
For the full leaf of North America amaranth dried leaf, fragment or powder or they with arbitrary proportion mix mixture.
4. composition according to claim 1, it is characterised in that: the vitamin D is vitamine D1, calciferol, dimension
In raw element D3, vitamine D4, Vitamin D5, vitamin D 6 or their derivative any one or it is any number of.
5. composition described in any one according to claim 1~4, it is characterised in that: in the composition, North America amaranth and dimension
The ratio of raw element D is 1g:(1~350) IU, preferably 1g:1,2,3,4.5.10,15,20,25,30,40,50,60,75,100,
125,150,175,200,225,250,275,300,325 or 350IU.
6. composition described in any one according to claim 1~4, it is characterised in that: in the composition, North America amaranth and dimension
The ratio of raw element D is 1g:(1-2000) IU, 2g:100IU or 5g:400IU.
7. composition described in any one according to claim 1~6, it is characterised in that: also contain mineral in the composition
Matter, organic matter, vitamin, amino acid or the nutriment eaten suitable for the mankind.
8. composition according to claim 7, it is characterised in that: the composition includes following any one or more of object
Matter: such as: zinc, copper, iodine, chromium, iron, molybdenum, selenium, silicon, boron, vanadium, germanium, potassium, calcium, phenol, sterol, free fatty acid;Vitamin C, dimension life
Plain E, vitamin B-6 and other vitamins, lysine, glycine and tyrosine;Sea-buckthorn, lycopene, Quercetin, African pea
Beans pierce nettle, pumpkin seed oil, chinaroot greenbrier, ginseng, milk thistle, kelp, pollen, linseed, beeswax, glycine.
9. a kind of food, health food or drug, it is characterised in that: it is with group described in claim 1~8 any one
Close object bulk pharmaceutical chemicals, either using its water or extractive with organic solvent as active constituent, and pharmaceutically acceptable auxiliary material or
The preparation that the complementary ingredient of person is prepared.
10. food according to claim 9, health food or drug, it is characterised in that: the food is children's food
Product;And/or the food is candy, bread, cake, biscuit.
11. food according to claim 9, health food or drug, it is characterised in that: the preparation is oral system
Agent.
12. food according to claim 11, health food or drug, it is characterised in that: the preparation is energy drink
Material, tea, coffee, lemonade, fruit juice, fruit drink, soft drink, water, seasoning water drinks or nutritious drink.
13. food according to claim 11, health food or drug, it is characterised in that: the preparation is medicinal tea, glue
Wafer, tablet, oral solution, powder, decoction, granule or pill.
14. food according to claim 13, health food or drug, it is characterised in that: the capsule or piece
In agent, the ratio of North America amaranth and vitamin D is 0.6718g:400IU.
15. food according to claim 13, health food or drug, it is characterised in that: the capsule or piece
In agent, in every 1 capsule or tablet, the weight of North America amaranth is 0.6718g, vitamin D 400IU.
16. food according to claim 13, health food or drug, it is characterised in that: every 1 capsule or tablet
In, contain 0.1,0.2,0.5,1.0,2.0,3.0,4.0,5.0,7.0,10,15,20,25,50,100,150,200,250 or
500 grams of North America amaranths.
17. according to food described in claim 9~16 any one, health food or drug, it is characterised in that: described auxiliary
Material is filler, preservative, colorant, sweetener or the flavoring agent eaten suitable for the mankind.
18. a kind of method for preparing food described in claim 9~17 any one, health food or drug, feature
Be: steps are as follows: taking the raw material of the North America amaranth in composition described in claim 1~8 any one, or carries out water and mention
Or organic solvent extracts, and vitamin D or derivatives thereof is added, and adds pharmaceutically acceptable auxiliary material or complementary ingredient,
?.
19. a kind of health beverages, it is characterised in that: it includes described in water penetration container and claim 1~8 any one
Composition, the composition are placed in water penetration container.
20. health beverages according to claim 19, it is characterised in that: in the health beverages, North America amaranth and vitamin D
Ratio be 2g:100IU or 5g:400IU.
21. health beverages according to claim 20, it is characterised in that: contain 0.1,0.2 in every 1 health beverages,
0.5,1.0,2.0,3.0,4.0,5.0,7.0,10,15,20,25,50,100,150,200,250 or 500 gram of North America amaranth.
22. health beverages described in 9~21 any one according to claim 1, it is characterised in that: the water penetration container is by filtering
Made by paper, nylon or silk;The preferably tea bag of tea bag.
23. a kind of method for preparing health beverages described in claim 19~22 any one, it is characterised in that: steps are as follows:
Composition described in claim 1~8 any one is taken, is packed into water penetration container, sealing.
24. composition described in claim 1~8 any one, food, health care described in claim 9~17 any one
Health beverages described in food or drug, claim 19~22 any one are in preparation treatment or assist in the treatment of inflammation
Purposes in food, health food or drug.
25. composition described in claim 1~8 any one, food, health care described in claim 9~17 any one
Health beverages described in food or drug, claim 19~22 any one are in preparation treatment or adjuvant treatment joint
Food, the health care of inflammation, benign prostatic hyperplasis, women prostate occlusive syndrome, urogenital infections and/or hemorrhoid inflammation
Purposes in food or drug;Preferably, the arthritis is rheumatoid arthritis.
26. composition described in claim 1~8 any one, food, health care described in claim 9~17 any one
Health beverages described in food or drug, claim 19~22 any one improve immunity of organisms in preparation and/or swash
Purposes in the food of vitamin D receptor living, health food or drug.
27. composition described in claim 1~8 any one, food, health care described in claim 9~17 any one
Health beverages described in food or drug, claim 19~22 any one preparation treatment metabolic syndrome food,
Purposes in health food or drug.
28. the bulk pharmaceutical chemicals of composition described in claim 1~8 any one are preparing the purposes in animal feed.
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US20120164240A1 (en) * | 2010-12-22 | 2012-06-28 | Audino David Lawrence | Enriched a. blitoides compositions and uses thereof |
US20160331796A1 (en) * | 2010-12-22 | 2016-11-17 | David AUDINO | Enriched amaranthus blitoides compositions and uses thereof |
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