CN109730250A - A kind of anti-oxidation health alimentation composition and preparation method thereof containing algae extract - Google Patents
A kind of anti-oxidation health alimentation composition and preparation method thereof containing algae extract Download PDFInfo
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Abstract
The invention discloses a kind of anti-oxidation health alimentation composition containing algae extract, prepares raw material and is composed of the following parts by weight: 20~30 parts of oat Ultramicro-powder, 10~15 parts of wheat germ powder, 20~30 parts of glycyrrhiza glabra rhizome, 10~20 parts of marigold, 1~3 part of chlorella extract, 3~5 parts of haematococcus pluvialis extract, 3~5 parts of halimasch, 1~3 part of pollen pini, 3~5 parts of trehalose.The preparation method of the present invention also provides a kind of anti-oxidation health alimentation composition containing algae extract.Present invention combination traditional Chinese medicine integration of drinking and medicinal herbs mechanism and nutrition, together by a variety of natural material reasonable compatibilities, play good anti-oxidant and strengthen immunity double effects, in addition, anti-oxidation health alimentation composition of the invention is prepared using pure natural raw material, edible safety, it is in good taste, obvious effect, it is without any side effects, it has a good application prospect.
Description
Technical field
The invention belongs to health product technology fields, and in particular to a kind of anti-oxidation health nutrient combination containing algae extract
Object and preparation method thereof.
Background technique
The oxidation mechanism of human body is to update tissue as target, but human body is with advancing age, body function decline, or
Obstinate disease or unsound life style etc., easily cause body excessive oxidation and injury tissue, organ.Traditional Chinese medicine is recognized
Are as follows: overstrain may lead to decline of vital energy, idleness bringing about stagnation of QI, always then laboured breathing, especially food drink does not save, delicious food savoury is excessive etc., more easily cause body constitution
Decline, be often presented with the bodily form obesity, abdomen grossness is soft, and skin of face grease is more, aversion to cold and cold limbs, greenish-yellow complexion and it is dark,
Eye born of the same parents are micro- floating, are easy sleepy, tongue body hypertrophy, not well, the loose stool of body weight.The mostly dirty vigour virtual loss of lung spleen kidney three, the deficiency of yang are powerless
It is metabolized not normal and is formed, the health care product of anti-oxidation efficacy has the very big market space.
Antioxidant in existing diet has certain validity to the prevention of a variety of diseases, but in environment to people
Body negative effect factor become increasingly complex it is changeable, if haze weather to human body invade, cause respiratory disease frequently to occur；
Electronic product is used for a long time in office, causes the stimulus such as radiation to increase body effect, and then lead to various chronic diseases
Potential generation etc., antioxidant in the prior art have been unable to satisfy disease prevention that is more and more diversified and complicating.Cause
This, it is necessary to a kind of new anti-oxidation health object be developed, to overcome drawbacks described above.
Summary of the invention
The present invention provides a kind of anti-oxidation health alimentation composition containing algae extract, solve in the prior art by
The variability of external condition in environment, it is pre- that existing antioxidant has been unable to satisfy disease that is more and more diversified and complicating
Anti- problem.
The first purpose of the invention is to provide a kind of the anti-oxidation health alimentation composition containing algae extract, preparation
Raw material is composed of the following parts by weight: 20~30 parts of oat Ultramicro-powder, 10~15 parts of wheat germ powder, glycyrrhiza glabra root
20~30 parts of stem, 10~20 parts of marigold, 1~3 part of chlorella extract, 3~5 parts of haematococcus pluvialis extract, halimasch 3~
5 parts, 1~3 part of pollen pini, 3~5 parts of trehalose.
Preferably, the anti-oxidation health alimentation composition containing algae extract prepares raw material by following parts by weight
Group is grouped as: 25 parts of oat Ultramicro-powder, 10 parts of wheat germ powder, 25 parts of glycyrrhiza glabra rhizome, 15 parts of marigold, chlorella are extracted
2 parts of object, 4 parts of haematococcus pluvialis extract, 4 parts of halimasch, 2 parts of pollen pini, 4 parts of trehalose.
Preferably, the partial size of the oat Ultramicro-powder is 50 μm.
The preparation of a second object of the present invention is to provide a kind of anti-oxidation health alimentation composition containing algae extract
Method, comprising the following steps:
Step 1,20~30 parts of oat Ultramicro-powder, 10~15 parts of wheat germ powder, glycyrrhiza glabra rhizome are weighed by weight
20~30 parts, 10~20 parts of marigold, 1~3 part of chlorella extract, 3~5 parts of haematococcus pluvialis extract, halimasch 3~5
Part, 1~3 part of pollen pini, 3~5 parts of trehalose are spare；
Step 2, glycyrrhiza glabra rhizome weighed in step 1 is smashed it through into 20 meshes, obtains glycyrrhiza glabra rhizome powder, it is past
Addition weight is that the ethanol solution that the mass concentration of 5 times of glycyrrhiza glabra rhizome powder is 95% carries out ultrasound in glycyrrhiza glabra rhizome powder
Extraction, carries out ultrafiltration after having extracted, filtrate obtains the extraction of glycyrrhiza glabra rhizome after being concentrated under reduced pressure into the 1/3 of former filtrate volume
Object will obtain glycyrrhiza glabra rhizome extract freeze-dried powder after glycyrrhiza glabra rhizome extract freeze-drying；
Step 3, marigold weighed in step 1 is smashed it through into 60 meshes, then using ethyl alcohol as entrainer, with overcritical
Carbon dioxide recycle counter-current extraction 3h, extracting pressure 35Mpa, extraction temperature is 50 DEG C, and extraction finishes to obtain marigold extraction
Object will obtain marigold extract freeze-dried powder after the freeze-drying of marigold extract liquor；
Step 4, will halimasch weighed in step 1 activation after be inoculated in PDA culture medium carry out enrichment expand culture, training
Armillaria mellea fermented solution is obtained after supporting；Armillaria mellea will be obtained after Armillaria mellea fermented solution filters pressing, by armillaria mellea
Armillaria mellea freeze-dried powder is obtained after freeze-drying；
Step 5, by wheat germ powder weighed in step 1, chlorella extract, haematococcus pluvialis extract, pollen pini,
Glycyrrhiza glabra rhizome extract freeze-dried powder obtained in trehalose, step 2, marigold extract freeze-dried powder obtained in step 3
And armillaria mellea freeze-dried powder mixed powder obtained is broken in step 4, sieves with 100 mesh sieve, and obtains mixed powder, then into mixed powder
Weighed oat Ultramicro-powder in step 1 is added, is uniformly mixed to get the anti-oxidation health nutrition group containing algae extract described in
Close object.
Preferably, the concrete operations condition that ultrasound extracts in the step 2 are as follows: at 50 DEG C, power is the condition of 200w
Lower ultrasonic extraction 30min.
Preferably, the feedstock quality of entrainer is the 5% of feed carbon dioxide quality in the step 3.
Preferably, being freeze-dried in the step 2-4 specific steps are as follows:
3h is pre-chilled at -30 DEG C in material to be dried, is then placed in freeze dryer, is cooled to -30 DEG C rapidly in 2h, to
After material becomes block structure, it is warming up to 0 DEG C in 3h, is then cooled to -30 DEG C rapidly in 0.5h, becomes loose to material
After ice-like structure, vacuum system is opened, so that vacuum degree is slowly increased to 30Pa in 30min, is then turned on heating system, material is made to exist
It is to slowly warm up to 40 DEG C in 4h, vacuum degree and temperature-resistant is maintained in 5h, vacuum system is then shut off, restores pressure slowly
To normal pressure to get arrive freeze-dried powder；
Wherein, the material to be dried is the glycyrrhiza glabra rhizome extract in step 2, the extraction of the marigold in step 3
Armillaria mellea in object and step 4.
The performance of each raw material is as follows in the present invention:
Oat is the food of a kind of low sugar, high nutrition, and nutritive value is higher, is mainly manifested in nutrition, health care side
Face.Oat, which has, to reduce blood pressure, reduces cholesterol, prevention and treatment intestinal cancer, the medical value and health-care effect for preventing and treating heart disease.This
Outside, oat is that best antioxidation foodstuff row is stepped in only honor in five cereals rich in ingredients such as protein, calcium, riboflavin, thiamines
Row list, every suitable oat of daily ingestion can accelerate human metabolism, accelerate the synthesis of amino acid, promote cell turnover.
Wheat embryo is the nutriment of a kind of high protein, homovitamin E, low-heat, low fat, low cholesterol, contains vitamin B
More than 10 minerals such as race, vitamin D, unsaturated fatty acid, nucleic acid, folic acid, the pure and mild calcium of octacosane, iron, zinc, selenium etc. are
The supply source of ideal minor metallic element.The physiological activity efficiency of natural VE is synthesize VE nearly 30 in wheat embryo
Times, the generation of lipid oxide is prevented in vivo, protects cell membrane, inhibits free radical, promotes human metabolism, is delayed senescence,
Improve liver function.Glutathione peroxidase in wheat embryo enzyme is a kind of natural that effect is fabulous, is resisted
Oxidability is 500 times stronger than vitamin E, is a kind of effective efficiency factor of anti-cancer that delays senescence.28 contained by wheat embryo
Alkanol has the effect of enhancing endurance, energy and physical strength.
There is the very strong depigmentation of skin of antioxygenic activity in the histocyte of glycyrrhiza glabra rhizome, the function of lightening the stain at
Point, and be main component, i.e., glycyrrhiza glabra element and glycyrrhiza glabra are fixed.
Contain a large amount of lutein in marigold, lutein has stronger antioxidation, can inhibitory activity oxygen freedom
The activity of base prevents destruction of the active oxygen radical to normal cell.It is related it is demonstrated experimentally that active oxygen radical can be with DNA, egg
White matter, lipid react, and weaken their physiological function, and then cause such as cancer, artery sclerosis, increase the yellow evil spirit denaturation of rheological properties
The generation lutein of disease chronic diseases can by physically or chemically quenching effect inactivate singlet oxygen, thus protect body from
Injury, enhances the immunocompetence of body.
Chlorella is a kind of good green nourishing source food, with high protein, low fat, low sugar, it is low in calories and
The abundant advantage of vitamin, Mineral element content.Bead algae glycoproteins have antioxidation, can remove interior free yl.
Free radical is the intermediate product of human life activity's mesophytization reaction, this includes ultra-oxygen anion free radical (O2) and hydroxyl freedom
Base (OH) etc..
Haematococcus pluvialis mainly contains astaxanthin, and astaxanthin is a kind of important carotenoid, but with carrotene and
Vitamin E etc. is compared, and it is the substance for belonging to human-body safety that astaxanthin, which has stronger bioactivity,.The anti-oxidant work of astaxanthin
Property is about 10 times higher than beta carotene, and about 500 times higher than vitamin E, astaxanthin has been considered as " supper vitamin E ", has
Wide application value.Astaxanthin has unique effect and purposes at many aspects, can prevent lipid peroxidation, protects machine
Body escapes injury, and pre- anti-cancer occurs, moreover it is possible to and promote the generation of human immunoglobulin, there is very high immunoregulatory activity,
There is good therapeutic effect to UV-induced cutaneum carcinoma, also have preferable preventive and therapeutic effect to the eye disease as caused by diabetes,
Have wide practical use in terms of functional food and medicine.
Contain polyalcohol, phenol, organic acid, ester type compound, purine, derivative, Protoilludanes in the mycelium of halimasch
Type sequiterpene aromatic esters etc..Halimasch is full of nutrition, also has medical value.It is reported that dry mushroom contains crude protein 11.4%, rouge
Fat 5.2%, carbohydrate 75.9%, cellulose 5.8%, ash content 7.5%, 384 kilocalories of heat.Also the Soviet Union containing D- comes in fructification
Alcohol, vitamin A etc. are powerful to treatment lumbocrural pain, rickets, epileptics.Often edible halimasch, can prevent eyesight and subtract
It moves back, yctalopia, dry skin, and human body can be enhanced to the resistance of certain respiratory tracts and infectious disease of the digestive tract.
Pollen pini is the spermatid of pine tree pistil, containing whole nutritions needed for most long-lived life entity, including
Multiple proteins, amino acid, minerals, enzyme and coenzyme, nucleic acid, monosaccharide, polysaccharide etc., total content is up to more than 200.Ingredient collocation is closed
Reason, can supplement, nutrition needed for balancing human body comprehensively.Its health-care effect is big, and conditioning range is wide, all ages and classes, different constitutions
User, all can receive good effect to varying degrees in a relatively short period of time.
Trehalose is a kind of best Sweet flavor modifier, is able to maintain the original local flavor of product but does not damage product storage
Phase.In addition, due to the stability of trehalose property hydrolysis will not be generated, product color is constant and keeps original gloss.
Based on this, present invention incorporates traditional Chinese medicine integration of drinking and medicinal herbs mechanism and nutrition, and above-mentioned each raw material component is closed
Reason collocation, promotes mutually, mutually cooperates with, and the anti-oxidation health alimentation composition for integrating nutrition and conditioning is prepared.This
The anti-oxidation health alimentation composition of invention can play oxidation resistant effect, and raw material is equal according to the needs of modern consumer
It is in good taste without any side effect for natural material, firmly get liking for consumer.
Compared with prior art, the beneficial effects of the present invention are:
Present invention combination traditional Chinese medicine integration of drinking and medicinal herbs mechanism and nutrition, by chlorella extract, haematococcus pluvialis extract
Together with a variety of natural material reasonable compatibilities, good anti-oxidant and strengthen immunity double effects are played, are prepared
Anti-oxidation health alimentation composition can effectively remove by force internal a variety of free radicals, have stronger antioxygenic property；In addition,
The anti-oxidation health alimentation composition that the present invention prepares can also improve the immunocompetence of immune cell, maintain in body
Environmental balance has excellent effect to maintenance human health.
Anti-oxidation health alimentation composition of the invention is prepared using pure natural raw material, and edible safety is in good taste, and effect is aobvious
It writes, and without any side effects, has a good application prospect.
Specific embodiment
In order to enable those skilled in the art to more fully understand, technical solution of the present invention is practiced, below with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
The test method of actual conditions is not specified in following embodiments, according to conventional methods in the art with condition into
Row, if material used is commercially available without specified otherwise.
Embodiment 1
A kind of anti-oxidation health alimentation composition containing algae extract, prepares raw material by the component of following parts by weight
Composition: 25 parts of oat Ultramicro-powder, 10 parts of wheat germ powder, 25 parts of glycyrrhiza glabra rhizome, 15 parts of marigold, chlorella extract 2
Part, 4 parts of haematococcus pluvialis extract, 4 parts of halimasch, 2 parts of pollen pini, 4 parts of trehalose.
It is specific the preparation method is as follows:
Step 1,25 parts of oat Ultramicro-powder, 10 parts of wheat germ powder, 25 parts of glycyrrhiza glabra rhizome, Wan Shou are weighed by weight
15 parts of chrysanthemum, 2 parts of chlorella extract, 4 parts of haematococcus pluvialis extract, 4 parts of halimasch, 2 parts of pollen pini, 4 parts of trehalose, it is standby
With；
Step 2, glycyrrhiza glabra rhizome weighed in step 1 is smashed it through into 20 meshes, obtains glycyrrhiza glabra rhizome powder, it is past
Addition weight is that the ethanol solution that the mass concentration of 5 times of glycyrrhiza glabra rhizome powder is 95% carries out ultrasound in glycyrrhiza glabra rhizome powder
Extraction, wherein the operating condition of ultrasound extraction is, at 50 DEG C, ultrasound extraction 30min under conditions of power is 200w；Extraction
Ultrafiltration is carried out after complete, filtrate obtains glycyrrhiza glabra rhizome extract after being concentrated under reduced pressure into the 1/3 of former filtrate volume, by the light
Glycyrrhiza glabra rhizome extract freeze-dried powder is obtained after the freeze-drying of fruit Radix Glycyrrhizae rhizome extract；
Step 3, marigold weighed in step 1 is smashed it through into 60 meshes, then using ethyl alcohol as entrainer, with overcritical
Carbon dioxide recycle counter-current extraction 3h, extracting pressure 35Mpa, extraction temperature is 50 DEG C, and extraction finishes to obtain marigold extraction
Object will obtain marigold extract freeze-dried powder after the freeze-drying of marigold extract liquor；
Step 4, will halimasch weighed in step 1 activation after be inoculated in PDA culture medium carry out enrichment expand culture, training
Armillaria mellea fermented solution is obtained after supporting；Armillaria mellea will be obtained after Armillaria mellea fermented solution filters pressing, by armillaria mellea
Armillaria mellea freeze-dried powder is obtained after freeze-drying；
Step 5, by wheat germ powder weighed in step 1, chlorella extract, haematococcus pluvialis extract, pollen pini,
Glycyrrhiza glabra rhizome extract freeze-dried powder obtained in trehalose, step 2, marigold extract freeze-dried powder obtained in step 3
And crushed after armillaria mellea freeze-dried powder obtained mixing in step 4, it sieves with 100 mesh sieve, obtains mixed powder, then toward mixed powder
Weighed oat Ultramicro-powder in middle addition step 1 is uniformly mixed to get the anti-oxidation health nutrient combination containing algae extract is arrived
Object.
Apply example 2
A kind of anti-oxidation health alimentation composition containing algae extract, prepares raw material by the component of following parts by weight
Composition: 20 parts of oat Ultramicro-powder, 15 parts of wheat germ powder, 20 parts of glycyrrhiza glabra rhizome, 10 parts of marigold, chlorella extract 3
Part, 5 parts of haematococcus pluvialis extract, 3 parts of halimasch, 1 part of pollen pini, 5 parts of trehalose.
The preparation method is the same as that of Example 1 for embodiment 2, the difference is that formula is different.
Embodiment 3
A kind of anti-oxidation health alimentation composition containing algae extract, prepares raw material by the component of following parts by weight
Composition: 30 parts of oat Ultramicro-powder, 10 parts of wheat germ powder, 25 parts of glycyrrhiza glabra rhizome, 10 parts of marigold, chlorella extract 1
Part, 3 parts of haematococcus pluvialis extract, 5 parts of halimasch, 3 parts of pollen pini, 3 parts of trehalose.
The preparation method is the same as that of Example 1 for embodiment 3, the difference is that formula is different.
Embodiment 4
A kind of anti-oxidation health alimentation composition containing algae extract, prepares raw material by the component of following parts by weight
Composition: 25 parts of oat Ultramicro-powder, 15 parts of wheat germ powder, 30 parts of glycyrrhiza glabra rhizome, 20 parts of marigold, chlorella extract 1
Part, 3 parts of haematococcus pluvialis extract, 3 parts of halimasch, 1 part of pollen pini, 3 parts of trehalose.
The preparation method is the same as that of Example 1 for embodiment 4, the difference is that formula is different.
Embodiment 5
A kind of anti-oxidation health alimentation composition containing algae extract, prepares raw material by the component of following parts by weight
Composition: 20 parts of oat Ultramicro-powder, 10 parts of wheat germ powder, 20 parts of glycyrrhiza glabra rhizome, 10 parts of marigold, chlorella extract 3
Part, 5 parts of haematococcus pluvialis extract, 5 parts of halimasch, 3 parts of pollen pini, 5 parts of trehalose.
The preparation method is the same as that of Example 1 for embodiment 5, the difference is that formula is different.
Embodiment 6
A kind of anti-oxidation health alimentation composition containing algae extract, prepares raw material by the component of following parts by weight
Composition: 25 parts of oat Ultramicro-powder, 12 parts of wheat germ powder, 25 parts of glycyrrhiza glabra rhizome, 15 parts of marigold, chlorella extract 2
Part, 4 parts of haematococcus pluvialis extract, 4 parts of halimasch, 2 parts of pollen pini, 4 parts of trehalose.
The preparation method is the same as that of Example 1 for embodiment 6, the difference is that formula is different.
It should be noted that the feedstock quality of entrainer is the 5% of feed carbon dioxide quality in step 3.
Need further exist for explanation, it is being freeze-dried in step 2-4 specific steps are as follows:
3h is pre-chilled at -30 DEG C in material to be dried, is then placed in freeze dryer, is cooled to -30 DEG C rapidly in 2h, to
After material becomes block structure, it is warming up to 0 DEG C in 3h, is then cooled to -30 DEG C rapidly in 0.5h, becomes loose to material
After ice-like structure, vacuum system is opened, so that vacuum degree is slowly increased to 30Pa in 30min, is then turned on heating system, material is made to exist
It is to slowly warm up to 40 DEG C in 4h, vacuum degree and temperature-resistant is maintained in 5h, vacuum system is then shut off, restores pressure slowly
To normal pressure to get arrive freeze-dried powder；
Wherein, the material to be dried is the glycyrrhiza glabra rhizome extract in step 2, the extraction of the marigold in step 3
Armillaria mellea in object and step 4.
In order to illustrate effect of the invention, comparative experiments has also been devised in experiment, specific processing mode is as follows.
Comparative example 1
Specific formula and preparation step with embodiment 1, the difference is that in formula without be added chlorella extract and
Haematococcus pluvialis extract.
Comparative example 2
Specific formula and preparation step are with embodiment 1, the difference is that halimasch and pollen pini is not added in formula.
Examples 1 to 6 has prepared the anti-oxidation health alimentation composition containing algae extract to work well, below
It is tested using performance of the zoopery to the anti-oxidation health alimentation composition containing algae extract that the present invention prepares,
To illustrate the effect of Examples 1 to 6.It should be noted that the antioxygen containing algae extract prepared due to Examples 1 to 6
It is similar to change health nutrient composition properties, therefore only using embodiment 1 as explanation.
1, experimental animal
Old-age group SPF grades of December healthy kunming mice, half male and half female.
2, experimental method
Old-age group SPF grades of healthy kunming mice in December is randomly divided into 6 groups, every group 10, respectively low dose group, middle dosage
Group, high dose group, aged controls group, control group 1 and control group 2.Wherein, low dose group, middle dose group, high dose group are tested
The daily feeding amount of object is respectively health nutrient composition prepared by 0.5g/kg, 2.5g/kg, 5.0g/kg embodiment 1；Aged controls
Normal conventional feed, the health nutrient composition that 1 feeding comparative example 1 of control group is prepared, and the day feeding amount of feeding of group is 2.5g/
kg；The health nutrient composition that 2 feeding comparative example 2 of control group is prepared, and day feeding amount is 2.5g/kg；6 groups of mouse continuously feed
It is put to death after supporting 30 days, then surveys Serum MDA (MDA), reductive glutathione content (GSH), anti-oxidant enzyme activity in Mice Body
Power.
3, statistical procedures
Using SPSS11.0 statistical software carry out statistical disposition, measurement data data withIt indicates, with multiple samples
The one-way analysis of variance that mean compares, enumeration data use x2It examines.
4, experimental result
Lipid oxidation products, protein oxidation products, antioxidase, three positives in antioxidant four indices, can
Determine that the given the test agent anti-oxidation function results of animal is positive.
(1) to the influence of MDA content in animal blood serum
MDA level is shown in Table 1 in groups of animals serum.
MDA concentration in 1 animal blood serum of table
Note: compared with aged controls group,*P<0.01。
As known from Table 1, after being fed 30 days using anti-oxidation health alimentation composition made from embodiment 1, in mice serum
MDA concentration obviously lowers, and illustrates that low, middle and high dose groups animal has significant difference compared with aged controls group animal；Control
1 animal feeding of group is after 30 days, and for MDA concentration compared with aged controls group, difference is unobvious in mice serum, illustrates that chlorella is extracted
Object, haematococcus pluvialis extract contribute entire anti-oxidation health alimentation composition anti-oxidation function very big；
2 animal feeding of control group is after 30 days, and for MDA concentration compared with aged controls group, difference is obvious in mice serum, but not
And test sample group effect is good, illustrates that halimasch and pollen pini have entire anti-oxidation health alimentation composition anti-oxidation function
Certain contribution, but still chlorella extract and the haematococcus pluvialis extract to play a major role；
Test sample group is compared with aged controls group, and MDA concentration reduces statistically significant, experimental result in mice serum
For the positive.
(2) to the influence of reductive glutathione content
The measurement result of GSH content is shown in Table 2 in animal blood serum
GSH concentration in 2 animal blood serum of table
Note: compared with aged controls group,*P<0.01。
As shown in Table 2, after being fed 30 days using anti-oxidation health alimentation composition made from embodiment 1, in mice serum
GSH content is significantly higher than aged controls group, and GSH content becomes compared with aged controls group without significant in 1 mice serum of control group
Change, GSH content is significantly higher than aged controls group in 2 mice serum of control group, but lower than given the test agent, illustrates halimasch and preserved egg
Powder has certain contribution to entire anti-oxidation health alimentation composition anti-oxidation function, but the still chlorella to play a major role
Extract and haematococcus pluvialis extract.The anti-oxidation health alimentation composition that the present invention prepares, which has, keeps GSH concentration raised
Effect, this index result are positive.
(3) to the influence of mice serum antioxidase activity
The measurement of superoxide dismutase (SOD) vigor and glutathione peroxidase (GSH-Px) vigor in animal blood serum
It the results are shown in Table 3.
SOD vigor and GSH-Px vigor in 3 animal blood serum of table
Note: compared with aged controls group,*P<0.01。
As shown in Table 3, after being fed 30 days using anti-oxidation health alimentation composition made from embodiment 1, mice serum SOD
Vigor and GSH-Px vigor are significantly raised, but 1 mice serum SOD vigor of control group and GSH-Px vigor have no significant change,
2 mice serum SOD vigor of control group and GSH-Px vigor are significantly higher than aged controls group, test sample group and aged controls group ratio
Compared with the raising of mice serum antioxidase activity is statistically significant, and experimental result is the positive.
It follows that the low, middle and high dose groups mouse of the anti-oxidation health alimentation composition of the feeding embodiment of the present invention 1
Compared with aged controls group, MDA level is significantly reduced in serum, antioxidant GSH content, SOD activity, GSH-Px activity
It is significant to increase, show that anti-oxidation health alimentation composition of the invention has good anti-oxidant, health-care efficacy.
It should be noted that involved in claims of the present invention when numberical range, it is thus understood that each numberical range
Any one numerical value can be selected between two endpoints and two endpoints, due to step method and the Examples 1 to 6 phase of use
Together, it repeats in order to prevent, description of the invention preferred embodiment, once a person skilled in the art knows basic
Creative concept, then additional changes and modifications may be made to these embodiments.It is wrapped so the following claims are intended to be interpreted as
It includes preferred embodiment and falls into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (7)
1. a kind of anti-oxidation health alimentation composition containing algae extract, which is characterized in that it prepares raw material by following weight
The group of number is grouped as: 20~30 parts of oat Ultramicro-powder, 10~15 parts of wheat germ powder, 20~30 parts of glycyrrhiza glabra rhizome, ten thousand
10~20 parts of longevity chrysanthemum, 1~3 part of chlorella extract, 3~5 parts of haematococcus pluvialis extract, 3~5 parts of halimasch, pollen pini 1~
3 parts, 3~5 parts of trehalose.
2. the anti-oxidation health alimentation composition according to claim 1 containing algae extract, which is characterized in that it is prepared
Raw material is composed of the following parts by weight: 25 parts of oat Ultramicro-powder, 10 parts of wheat germ powder, 25 parts of glycyrrhiza glabra rhizome,
15 parts of marigold, 2 parts of chlorella extract, 4 parts of haematococcus pluvialis extract, 4 parts of halimasch, 2 parts of pollen pini, 4 parts of trehalose.
3. the anti-oxidation health alimentation composition according to claim 1 or 2 containing algae extract, which is characterized in that institute
The partial size for stating oat Ultramicro-powder is 50 μm.
4. the preparation method of the anti-oxidation health alimentation composition according to claim 1 containing algae extract, feature
It is, comprising the following steps:
Step 1, weigh by weight 20~30 parts of oat Ultramicro-powder, 10~15 parts of wheat germ powder, glycyrrhiza glabra rhizome 20~
30 parts, 10~20 parts of marigold, 1~3 part of chlorella extract, 3~5 parts of haematococcus pluvialis extract, 3~5 parts of halimasch, pine
1~3 part of pollen, 3~5 parts of trehalose, it is spare；
Step 2, glycyrrhiza glabra rhizome weighed in step 1 is smashed it through into 20 meshes, obtains glycyrrhiza glabra rhizome powder, toward light fruit
Addition weight is that the ethanol solution that the mass concentration of 5 times of glycyrrhiza glabra rhizome powder is 95% carries out ultrasonic leaching in Radix Glycyrrhizae rhizome powder
It mentioning, carries out ultrafiltration after having extracted, filtrate obtains glycyrrhiza glabra rhizome extract after being concentrated under reduced pressure into the 1/3 of former filtrate volume,
Glycyrrhiza glabra rhizome extract freeze-dried powder will be obtained after glycyrrhiza glabra rhizome extract freeze-drying；
Step 3, marigold weighed in step 1 is smashed it through into 60 meshes, then using ethyl alcohol as entrainer, with overcritical dioxy
Change carbon cycle counter-current extraction 3h, extracting pressure 35Mpa, extraction temperature is 50 DEG C, and extraction finishes to obtain marigold extract, will
Marigold extract freeze-dried powder is obtained after the freeze-drying of marigold extract liquor；
Step 4, will halimasch weighed in step 1 activation after be inoculated in PDA culture medium carry out enrichment expand culture, cultivated
Armillaria mellea fermented solution is obtained after finishing；Armillaria mellea will be obtained after Armillaria mellea fermented solution filters pressing, armillaria mellea is freezed
Armillaria mellea freeze-dried powder is obtained after drying；
Step 5, by wheat germ powder weighed in step 1, chlorella extract, haematococcus pluvialis extract, pollen pini, seaweed
Sugar, glycyrrhiza glabra rhizome extract freeze-dried powder obtained in step 2, in step 3 marigold extract freeze-dried powder obtained and
Armillaria mellea freeze-dried powder mixed powder obtained is broken in step 4, sieves with 100 mesh sieve, and obtains mixed powder, then be added into mixed powder
Weighed oat Ultramicro-powder in step 1 is uniformly mixed to get the anti-oxidation health nutrient combination containing algae extract described in
Object.
5. the preparation method of the anti-oxidation health alimentation composition according to claim 4 containing algae extract, feature
It is, the concrete operations condition of ultrasound extraction in the step 2 are as follows: at 50 DEG C, power is ultrasonic extraction under conditions of 200w
30min。
6. the preparation method of the anti-oxidation health alimentation composition according to claim 4 containing algae extract, feature
It is, the feedstock quality of entrainer is the 5% of feed carbon dioxide quality in the step 3.
7. the preparation method of the anti-oxidation health alimentation composition according to claim 4 containing algae extract, feature
Be, it is being freeze-dried in the step 2-4 specific steps are as follows:
3h is pre-chilled at -30 DEG C in material to be dried, is then placed in freeze dryer, is cooled to -30 DEG C rapidly in 2h, to material
After becoming block structure, it is warming up to 0 DEG C in 3h, is then cooled to -30 DEG C rapidly in 0.5h, becomes loose ice-like to material
After structure, vacuum system is opened, so that vacuum degree is slowly increased to 30Pa in 30min, is then turned on heating system, makes material in 4h
40 DEG C are to slowly warm up to, vacuum degree and temperature-resistant is maintained in 5h, vacuum system is then shut off, is restored to pressure slowly often
It presses to get freeze-dried powder is arrived；
Wherein, the material to be dried be step 2 in glycyrrhiza glabra rhizome extract, the marigold extract in step 3 with
And the armillaria mellea in step 4.
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| CN104432037A (en) * | 2014-11-24 | 2015-03-25 | 广州市香雪制药股份有限公司 | Antioxidative health care nutrition composition, as well as preparation method and application thereof |
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Application publication date: 20190510 |