CN109718136A - A kind of skin liniment based on wormwood essential oil, phosphatide and pyrroloquinoline quinone - Google Patents
A kind of skin liniment based on wormwood essential oil, phosphatide and pyrroloquinoline quinone Download PDFInfo
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- CN109718136A CN109718136A CN201910075804.0A CN201910075804A CN109718136A CN 109718136 A CN109718136 A CN 109718136A CN 201910075804 A CN201910075804 A CN 201910075804A CN 109718136 A CN109718136 A CN 109718136A
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- essential oil
- pyrroloquinoline quinone
- skin
- wormwood essential
- phosphatide
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Abstract
The present invention relates to a kind of skin liniment, it includes: the wormwood essential oil of 5~15% weight;The phosphatide of 20~50% weight, preferably lecithin, more preferable hydrolecithin;The pyrroloquinoline quinone aqueous solution of 30~60% weight, preferred concentration are 0.05~0.5%, and preferred concentration is 0.1~0.15%.The invention further relates to the compositions of the liniment containing this mixture.Above-mentioned composition can delay wormwood essential oil to be absorbed into skin process after use, and enhancing pyrroloquinoline quinone penetrates into the ability of skin, play and play three kinds of basic substances to skin and human body and integrated protection effect.
Description
Technical field
The present invention relates to a kind of mixture skin liniments, in particular to a kind of wormwood essential oil, phosphatide and pyrroles's quinoline
Quinone is basic mixed component, and the skin liniment of fragrance is added.
Background technique
Wormwood essential oil is extracted from wormwood using extracting methods such as extraction, steam distillation, supercritical extractions
More composition volatile oil, it also includes aliphatic compound and aromatic compound etc. that main ingredient, which is small molecule terpenoid,.
By the actual use and scientific research of many years, it was demonstrated that wormwood essential oil have antibacterial, it is antimycotic, relieving asthma, inhibit platelet aggregation,
Hemostasis, analgesic, anti-inflammatory, promotes the effects of immunity at antiallergy, has been widely used in people's lives.Due to being a variety of
The mixture of composition composition, in use, there is the phenomenon that part of composition allergic reaction in part population.Meanwhile
Because main ingredient is liposoluble substance, skin infiltration rate is fast, further reduced the tolerance of allergic constitution crowd.
Pyrroloquinoline quinone abbreviation PQQ is after flavin nucleotide (FMN, FAD) and nicotinamide nucleotide (MAD, NADP)
The third prothetic group and a kind of new type water-solubility vitamin of mankind's discovery.As a kind of oxidoreducing enzyme prothetic group, can not only join
With catalysis biological vivo oxidation reduction reaction, but also have some special bioactivity and physiological function, micro PQQ is just
Metabolism and the growth function of bio-tissue can be improved, is had and is improved immunity, prevent hepatic injury, reduce free radical to human body wound
Evil improves various neurogenic diseases, promotes Amino Acid Absorption, promote synthesis growth factor and glutathione, prevent senile dementia
The effects of, or even discovery is studied also with certain anti-cancer function, therefore is referred to as " immune king ".Since PQQ is in stablizing bar
It needs to exist in the form of inorganic salts under part, usually a sodium salt or disodium salt, fat-soluble low, it is difficult to skin is penetrated into, because
This is not directly used as skin liniment generally, can not play in current cosmetics widely used superoxide dismutase SOD to skin
The protective effect of skin.
As can finding a kind of reduction skin to the infiltration rate of wormwood essential oil, while skin is promoted to the absorbability of PQQ
Method, then can effectively promote human body to the tolerance of wormwood essential oil, and play the powerful physiological function of PQQ, increase skin put on the skin
Adaptation population's range of agent improves liniment to the Global Macros effect of skin and human body.
Summary of the invention
To solve above-mentioned problems of the prior art, the present invention, which provides, utilizes Surfactant phospholipid substance and two
Kind group subassembly, and the method for being properly added fragrance.
Specific development process is as follows:
Influence of the phosphatide to wormwood essential oil skin absorption rate is added:
Wormwood essential oil that steam distillation obtains is mixed into emulsion with the phosphatide being dispersed in water, and with basis
The wormwood essential oil that oil is diluted to 10% concentration compares, and the two is coated on frosted glass plate as blank control, using gas phase
Skin is to the assimilation effect of effective ingredient in essential oil after a certain period of time for chromatography detection, and detection data is with gas-chromatography institute in original sample
Having component peak area summation is 100% calculating:
Time | Phosphatide emulsion | Base oil dilution |
It is absorbed after 15min | 13.80 | 67.44 |
It is absorbed after 30min | 25.70 | 89.40 |
It is absorbed after 1 hour | 44.79 | 98.88 |
It is absorbed after 2 hours | 69.52 | 99.99 |
It is absorbed after 4 hours | 90.71 | 100 |
It is absorbed after 8 hours | 99.14 | 100 |
It is absorbed after 16 hours | 99.99 | 100 |
Remarks one: wormwood essential oil, phosphatide, water weight ratio are 10:40:50 in this experiment.
Remarks two: being because wormwood essential oil itself has volatility using frosted glass coating purpose, blank can remove volatilization
Lose the influence to calculated result.
Remarks three: phosphatide used in this experiment is the mixture of a variety of phosphatide.
As seen from the above table, after the aqueous emulsion of Surfactant phospholipid is added, absorption rate of the skin to wormwood essential oil composition
Obviously slow down.Its reason is after dispersing due to phosphatide that the water in lotion can play certain between skin and wormwood essential oil
Barrier action.
The influence of Different Extraction Method wormwood essential oil addition non-phospholipid surfactants:
Identical experiment is done with the wormwood essential oil of n-hexane extraction and supercritical carbon dioxide extracting, with steam distillation number
It is as follows: according to comparing
Time | Steam distillation | N-hexane extraction method | Supercritical extraction |
It is absorbed after 15min | 13.80 | 17.64 | 11.95 |
It is absorbed after 30min | 25.70 | 32.17 | 22.47 |
It is absorbed after 1 hour | 44.79 | 53.99 | 39.89 |
It is absorbed after 2 hours | 69.52 | 78.83 | 63.87 |
It is absorbed after 4 hours | 90.71 | 95.52 | 86.95 |
It is absorbed after 8 hours | 99.14 | 99.80 | 98.30 |
It is absorbed after 16 hours | 99.99 | 100 | 99.97 |
As seen from the above table, phospholipid surface active is being added in the wormwood essential oil that n-hexane extraction method and supercritical extraction obtain
Equally have the effect of that skin absorption is slower after agent aqueous emulsion, illustrates that the method has wider adaptability.
The control of phosphatide and wormwood essential oil additional amount:
When very few water is added, phosphatide can not effectively disperse, unfavorable to hybrid manipulation, and very few phosphatide or mistake is added
When more wormwood essential oils, wormwood essential oil can not be effectively dispersed in water, storage can separate wormwood essential oil layer for a long time.By synthesis
Property experiment, Weight control is added 20~50% in phosphatide, and Weight control, which is added, in wormwood essential oil does not influence dispersion behaviour 5~15%
Make, and phosphatide dosage is also required to increase when the increase of essential oil weight.The water content of phosphatide has certain influence to operation simultaneously, low aqueous
The phosphatide of amount needs to reduce phosphatide and wormwood essential oil ratio, increase accordingly the ratio of water.
The selection of phosphatide:
In numerous phospholipid substances, (PC) containing phosphatidyl choline in egg yolk lecithin and soybean lecithin, to people
Body plays the role of both adjusting blood lipid, the dysbolism for improving memory, improving liver rouge, improving hypoxia-bearing capability, therefore select
Protective effect of the liniment described in this patent to human body and skin can be further promoted as surfactant.Moreover, due to
The quaternary amine alkali degree of ionization contained in PC is free of the phospholipid substance of quaternary amine relative to phosphatidylinositols, phosphatidyl-ethanolamine etc.
It is higher, ion-pair compound more effectively can be formed with PQQ, be entered in the essential oil of dispersion in the form of ion pair extraction,
PQQ is set to effectively enter skin by synergistic effect, the absorption rate and PQQ of PQQ when different phosphatide is as surfactant
It is as follows that aqueous solution is coated directly onto the data comparison on skin:
Time | PQQ aqueous solution | Pure PC | Pure phosphatidyl-ethanolamine |
It is absorbed after 15min | 0.23 | 9.77 | 4.78 |
It is absorbed after 30min | 0.46 | 18.59 | 9.33 |
It is absorbed after 1 hour | 0.92 | 33.72 | 17.79 |
It is absorbed after 2 hours | 1.83 | 56.07 | 32.42 |
It is absorbed after 4 hours | 3.62 | 80.70 | 54.33 |
It is absorbed after 8 hours | 7.10 | 96.27 | 79.14 |
It is absorbed after 16 hours | 13.70 | 99.86 | 95.69 |
Remarks: it is 10:40:50 that wormwood essential oil in the formula of phosphatide, phosphatide and PQQ solution ratio, which is added,;PQQ solution concentration
It is 0.1%.
After being stored 15 days using the liniment that PC is formulated, it has been found that liniment color burn occurs, has dense fishy smell
The phenomenon that, analysis may be that the impurity generated after the unsaturated compound in lecithin aoxidizes causes.We are by egg yolk lecithin
Hydrogen, ammonium formate and formic acid is respectively adopted as hydrogenant agent, after the reaction of the catalyst to catalyzing hydrogenating such as palladium carbon with soybean lecithin
Liniment is prepared again, does not occur this phenomenon again.It is therefore preferable that method is hydrolecithin as surfactant.
The selection of PQQ concentration:
The too low protective effect that can not be effectively played to skin of PQQ concentration, and concentration is too high then that dissolution is difficult in water, because
The concentration of this initial option 0.05~0.5%, which is used as, uses concentration.After being configured to liniment with the PQQ aqueous solution of this range of concentrations,
It was found that, since PQQ itself is red material, color is deeper on the skin for coating, for baring skin when being more than 0.2% concentration
Perception is bad, therefore final choice 0.1~0.15% is used as preferred PQQ aqueous solution compound concentration, is coated on skin under this concentration
On have the effect of similar kermes, be easy to that women user is allowed to receive.
PQQ dissolves pH selection:
PQQ is difficult to be dissolved in water in acid condition, although excessively high dissolution pH solubility increases, but results in two
A deficiency, second is that color transition occurs for PQQ under the conditions of high pH, is coated on skin first is that excessively high pH is irritating to the skin effect
Upper perception decline.By many experiments, under aforementioned each proportioning components, dissolution pH is best in 6~9 resultant effects.
Since the volatility of essential oil is larger, use process has some smells, and in wormwood essential oil user, certain customers are special
It is not that women experiences bad to this smell, or even therefore abandons using wormwood essential oil product, even if being covered using fragrance
Also the requirement of these users can not be fully met.And the liniment for using above method to prepare is due to the mixing of surfactant and water
The volatility of barrier action, essential oil is substantially reduced, and adding after fragrance can almost shield the smell of essential oil itself completely.Respectively
Kind of solid, liquid perfume have good effect, and when solid spice is added need to carry out micro mist, and obtained liniment is in suspension
Shape.
Since lecithin itself is a kind of surfactant, has the function of wash away grease, therefore match by described in this patent
The liniment of system can directly be washed with water after use, and no longer need using articless for washing such as perfumed soaps, and avoid with basis
The wormwood essential oil that oil is prepared use feeling greasy when using.
Specific embodiment
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, is all within the scope of the present invention.
The content of present invention is further explained and described below by way of example, but these examples are understood not to the present invention
The limitation of protection scope.
Embodiment 1
150mgPQQ is added with stirring in 45ml purified water, be slowly dropped into 1mol/L sodium hydroxide solution adjust pH to
8.0, it maintains the pH to continue stirring to whole dissolutions, purified water is added and is settled to 50ml.Take 20g egg yolk lecithin and 20g soybean
Lecithin is added with stirring both for product after hydrogenation into the above PQQ lysate, continues stirring until in uniform point
Object is dissipated, the stirring of 10g wormwood essential oil is added, until wormwood essential oil is fully dispersed in integral system.After adding 50mg micro mist
Menthol is dispersed with stirring completely.
Embodiment 2
120mgPQQ is added with stirring in 60ml purified water, be slowly dropped into 1mol/L sodium hydroxide solution adjust pH to
7.0, it maintains the pH to continue stirring to whole dissolutions, purified water is added and is settled to 70ml.25g hydrogenated yolk lecithin is taken, is stirred
Lower addition continues stirring until 5g wormwood essential oil and 50mg rhodamine toner is added in uniform dispersion into the above PQQ lysate
Oil stirring, until essential oil is fully dispersed in integral system.
Claims (16)
1. a kind of skin liniment, which mainly includes following component composition:
The wormwood essential oil of 5~15% weight,
The phosphatide of 20~50% weight,
The pyrroloquinoline quinone aqueous solution of 30~60% weight.
2. mixture described in claim 1, it is characterised in that the wormwood essential oil is the form of natural wormwood extract.
3. wormwood essential oil as claimed in claim 2, extracting method include but is not limited to solvent extraction, steam distillation,
Supercritical extraction etc..
4. mixture described in claim 1, it is characterised in that the phosphatide is lecithin.
5. according to claim 4, it is characterised in that the lecithin is egg yolk lecithin or soybean lecithin, or both mixing
Object.
6. according to claim 5, it is characterised in that or mixtures thereof the egg yolk lecithin or soybean lecithin are hydrogenations
Egg yolk lecithin or soybean lecithin afterwards, or both mixture.
7. the hydriding process to egg yolk lecithin or soybean lecithin includes but is not limited to hydrogen according to claim 6
Catalysis method, Catalyzed by Formic Acid method and formates catalysis method.
8. mixture described in claim 1, it is characterised in that the concentration of aqueous solution of the pyrroloquinoline quinone be 0.05~
0.5%.
9. pyrroloquinoline quinone aqueous solution according to any one of claims 8, it is characterised in that the concentration of aqueous solution of the pyrroloquinoline quinone is
0.1~0.15%.
10. pyrroloquinoline quinone aqueous solution described in claim 8~9, it is characterised in that pyrroloquinoline quinone is dissolved with sodium-salt form
Yu Shui.
11. pyrroloquinoline quinone aqueous solution described in claim 8~10, it is characterised in that the pyrroloquinoline quinone aqueous solution pH is
6~9.
12. mixing composition liniment described in claim 1, it is characterised in that its contained wormwood essential oil is absorbed into skin speed and is slower than often
Rule are with the diluted wormwood essential oil of base oil.
13. mixing composition liniment described in claim 1, it is characterised in that its contained pyrroloquinoline quinone can be absorbed into skin well
Skin.
14. mixing composition liniment described in claim 1, in addition to three kinds of wormwood essential oil, phosphatide and pyrroloquinoline quinone basic mixtures,
Its feature also includes at least one fragrance.
15. the mixing composition liniment of fragrance is added described in claim 14, it is characterized in that the form of suspension or lotion.
16. the feature that mixing composition liniment described in claim 1 has easy cleaning.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113876658A (en) * | 2021-11-01 | 2022-01-04 | 仙乐健康科技股份有限公司 | Oil-in-water emulsion composition and method for producing the same |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102166245A (en) * | 2011-04-06 | 2011-08-31 | 西北农林科技大学 | Oil in water type blumea oil nanoemulsion and preparation method thereof |
CN103340803A (en) * | 2013-07-18 | 2013-10-09 | 广州市一卡拉康美生物科技有限公司 | Micro-precision separation technique aiming at essential oil components |
CN103458865A (en) * | 2011-04-07 | 2013-12-18 | 日本乐敦制药株式会社 | Composition for external application |
CN107558243A (en) * | 2017-09-01 | 2018-01-09 | 南通香佳纺织科技有限公司 | A kind of wormwood essential oil and the microcapsules brassiere finishing agent and preparation method of Geranium Essential compounding |
US10100055B2 (en) * | 2016-12-26 | 2018-10-16 | Mitsuibishi Gas Chemical Company, Inc. | Imidazopyrroloquinoline salt, method for producing the same, medicament, cosmetic, and food |
-
2019
- 2019-01-25 CN CN201910075804.0A patent/CN109718136A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102166245A (en) * | 2011-04-06 | 2011-08-31 | 西北农林科技大学 | Oil in water type blumea oil nanoemulsion and preparation method thereof |
CN103458865A (en) * | 2011-04-07 | 2013-12-18 | 日本乐敦制药株式会社 | Composition for external application |
CN103340803A (en) * | 2013-07-18 | 2013-10-09 | 广州市一卡拉康美生物科技有限公司 | Micro-precision separation technique aiming at essential oil components |
US10100055B2 (en) * | 2016-12-26 | 2018-10-16 | Mitsuibishi Gas Chemical Company, Inc. | Imidazopyrroloquinoline salt, method for producing the same, medicament, cosmetic, and food |
CN107558243A (en) * | 2017-09-01 | 2018-01-09 | 南通香佳纺织科技有限公司 | A kind of wormwood essential oil and the microcapsules brassiere finishing agent and preparation method of Geranium Essential compounding |
Non-Patent Citations (1)
Title |
---|
常州灸世家健康科技有限公司: "艾妍堂艾草滋养乳", 《国产非特殊用途化妆品备案服务平台》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113876658A (en) * | 2021-11-01 | 2022-01-04 | 仙乐健康科技股份有限公司 | Oil-in-water emulsion composition and method for producing the same |
CN113876658B (en) * | 2021-11-01 | 2023-10-20 | 仙乐健康科技股份有限公司 | Oil-in-water emulsion composition and method for producing same |
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