JPS62263109A - Method for blending phospholipid stably - Google Patents

Method for blending phospholipid stably

Info

Publication number
JPS62263109A
JPS62263109A JP61102140A JP10214086A JPS62263109A JP S62263109 A JPS62263109 A JP S62263109A JP 61102140 A JP61102140 A JP 61102140A JP 10214086 A JP10214086 A JP 10214086A JP S62263109 A JPS62263109 A JP S62263109A
Authority
JP
Japan
Prior art keywords
phospholipid
aqueous solution
electrolyte
transparent
phospholipids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP61102140A
Other languages
Japanese (ja)
Inventor
Toshio Mikitani
御器谷 敏夫
Masanori Takenouchi
竹ノ内 正紀
Yoshio Okaya
岡谷 吉雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pola Orbis Holdings Inc
Original Assignee
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc filed Critical Pola Chemical Industries Inc
Priority to JP61102140A priority Critical patent/JPS62263109A/en
Publication of JPS62263109A publication Critical patent/JPS62263109A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26Optical properties
    • A61K2800/262Transparent; Translucent

Abstract

PURPOSE:To prevent reduction in quality of a transparent aqueous solution resulting from hydrolysis of phospholipid with time and to maintain long-term preservation of phospholipid stably, by blending the transparent aqueous solution containing phospholipid with a specific electrolyte and adjusting the blend into proper pH. CONSTITUTION:A transparent aqueous solution of a lower fatty alcohol containing phospholipid such as purified soybean phospholipid, etc., useful as hair tonic, skin medicine for promoting nutrition or surface active agent is blended with an inorganic and/or organic electrolyte so that phospholipid in the transparent aqueous solution is stabilized. An electrolyte having pH buffering action at pH 5.5-8.6 is used as the electrolyte and disodium hydrogenphosphate, sodium carbonate, sodium hydrogencarbonate, citric acid, sodium citrate, sodium polyacrylate, etc., may be cited as the electrolyte. The prepared phospholipid- containing aqueous solution shows transparent - semitransparent appearance, the phospholipid acts as a solubilizer and the aqueous solution is used as lotion or a gelatinous solution.

Description

【発明の詳細な説明】 本発明はリン脂質を安定に配合する方法に関する。従来
よりリン脂質は、毛髪・皮膚栄養剤として化粧品分野に
おいて配合することはよく行われてさたが、近年に至り
、これら毛髪・皮膚栄毘剤としてではなく、界面活性剤
として医療・化粧品・食品分野で用いようとする試みか
なされている。
DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for stably blending phospholipids. Traditionally, phospholipids have often been incorporated into cosmetics as hair and skin nourishing agents, but in recent years, phospholipids have been used as surfactants in medical products, cosmetics, and cosmetics, rather than as hair and skin nourishing agents. Attempts have been made to use it in the food field.

リン脂質は、合成界面活性剤と異なり、天然物a。Unlike synthetic surfactants, phospholipids are natural products.

であるため比較的安定性が高いとい、う利点を有する一
方、経時において各製品系での共存する添加物の分解に
より、系のpI−1の低下が起こりやすく、よってリン
脂質の加水分解か促進され、その結果・界面活性剤とし
て機能しなくなる傾向がある。実際、リン脂質を界面活
性剤として用いた乳化系、可溶化系の透明水溶液では経
日放置試験により外観が著しく変化することが観察され
た。一部において、リン脂質を界面活性剤として用いろ
際、トコフェロール・ステロール類を併用すると処方系
の安定性が向上する事が文献に報告されているが、本発
明台らの実験によると、この場合でも処方系のp I−
[か低下することが知見されたつすなわち、pi−[4
,5以丁になった系では、10℃、3ケ月間の経日で乳
化系では分離が、可溶化系では白濁が当初の状態と比較
して明らかな差がみとめられた。
Although it has the advantage of being relatively stable, over time, the pI-1 of the system tends to decrease due to the decomposition of coexisting additives in each product system, and therefore, the hydrolysis of phospholipids is likely to occur. as a result, it tends to cease to function as a surfactant. In fact, it was observed that the appearance of transparent aqueous solutions of emulsification and solubilization systems using phospholipids as surfactants changed significantly when left in storage tests over time. It has been reported in the literature that when phospholipids are used as surfactants, the stability of formulations is improved when tocopherols and sterols are used in combination. Even if the prescription system p I-
[i.e., pi-[4
, 5 in the system, after 3 months at 10°C, clear differences were observed in the emulsion system with separation and the solubilization system with cloudiness compared to the initial state.

そこで、本発明者らは、か\る現状に濫み、テア゛ン脂
質の加水分解とpl−1との関連を追及した結果、電解
質を用いろことにより、長期の保存においても透明性水
溶液中でリン脂質を安定に推持できろ方法を見出し、本
発明を完成するに至ったものである。
Therefore, the present inventors investigated the relationship between the hydrolysis of thean lipid and pl-1, and found that by using an electrolyte, a transparent aqueous solution can be obtained even during long-term storage. The inventors discovered a method for stably supporting phospholipids in the process, and completed the present invention.

すなイつち、本発明は、リン脂質を含有した透明性水溶
液に無機および/または有機の電解質が配合されてなる
ことを特徴とするリン脂質を安定に配合する方法に関す
るしのである。
In other words, the present invention relates to a method for stably blending phospholipids, which is characterized by blending an inorganic and/or organic electrolyte into a transparent aqueous solution containing phospholipids.

本発明リン脂質含有水溶液の安定化法においては、特に
緩衝作用を有する無機、有機の電解質が含有され、p 
Hを特定範囲に調整することにより、経時におけろリン
脂質の加水分解によって誘発される透明性水溶液の品質
低下を効果的に防止する二とかできる。
In the method for stabilizing a phospholipid-containing aqueous solution of the present invention, an inorganic or organic electrolyte having a buffering effect is contained, and p
By adjusting H within a specific range, it is possible to effectively prevent the quality deterioration of the transparent aqueous solution induced by the hydrolysis of phospholipids over time.

以下、本発明について詳述する。The present invention will be explained in detail below.

本発明に使用されるリン脂質としてはフオスファヂンル
コリン、フ十スファチジルイノシトール、フォスファヂ
ノルエタノールアミン、フオスファヂジルセリン、スフ
ィンゴミエリン等の大豆、卵黄その他動植物の組織に由
来する物質(例、大豆レノヂン、卵黄レノヂノ等)お上
、びこれらの精製物、水素添加物などがあり・、また、
合成リン脂質としては、ジステアロイルフオスファチノ
ルコリン、ジパルミトイルフォスファチジルコリン等が
挙げられろ。その他大腸菌等の微生物から抽出されるリ
ン脂質を用いてもよい。これらリン脂質のうち、フォス
ファチジルコリンを主成分として含有しフォスファチジ
ルエタノールアミンら含有するリン脂質は、水への溶解
性が良く、可溶化剤として好適に使用できる。
Phospholipids used in the present invention include substances derived from soybean, egg yolk, and other animal and plant tissues, such as phosphadin lucholine, phosphatidylinositol, phosphadinorethanolamine, phosphadydylserine, and sphingomyelin. (For example, soybean renojin, egg yolk renojin, etc.) There are also refined products and hydrogenated products of these.
Examples of synthetic phospholipids include distearoylphosphatinorcholine, dipalmitoylphosphatidylcholine, and the like. Other phospholipids extracted from microorganisms such as E. coli may also be used. Among these phospholipids, phospholipids containing phosphatidylcholine as a main component and phosphatidylethanolamine have good solubility in water and can be suitably used as a solubilizing agent.

本発明に用いられる電解質は、萌述のとおり、無機また
は有機のいずれでもよく、これらはl)H緩衝作用があ
り、か\る電解質を1種又は2種以上用いて透明性水溶
液に含有仕しめろらのである。
As mentioned above, the electrolyte used in the present invention may be either inorganic or organic, and these electrolytes have 1) H buffering effect, and are prepared by containing one or more of these electrolytes in a transparent aqueous solution. It's Shimerorano.

リン脂質はこの電解質を含有した水用に配合することが
できる。電解質として具体的なものを挙げると、例えば
、リン酸二水素ナトリウム、リン酸二水素カリウム、リ
ン酸水素二ナトリウム、クエン酸、クエン酸ナトリウム
、コハク酸ナトリウム、ホウ酸、炭酸ナトリウム、炭酸
水素ナトリウム、ポリアクリル酸ナトリウム、ポリアク
リル酸カリウム等が挙げられる。(電解質であっても例
えば水酸化ナトリウムなどは単独で使用しても経時で系
が化学変化を起こし、すみやかにpHが低下して白濁し
、系を安定に維持することができない傾向があり、単独
では本発明の目的には適さない。)上記電解質は本発明
の水溶液全重量中0.1〜5重量%望ましくは0.05
〜1重量%配合する。
Phospholipids can be formulated for this electrolyte-containing water. Specific examples of electrolytes include sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, citric acid, sodium citrate, sodium succinate, boric acid, sodium carbonate, and sodium hydrogen carbonate. , sodium polyacrylate, potassium polyacrylate, and the like. (Even if an electrolyte such as sodium hydroxide is used alone, the system will undergo chemical changes over time, the pH will quickly drop and it will become cloudy, and the system will tend to be unable to be maintained stably.) (It is not suitable for the purpose of the present invention alone.) The above electrolyte is contained in an amount of 0.1 to 5% by weight, preferably 0.05% by weight based on the total weight of the aqueous solution of the present invention.
~1% by weight is blended.

0.0IEli量%未満ては、1)I−(緩衝作用が小
さく、+) H低下が経時て生じて、リン脂質の加水分
解が促進され、白濁が生じやすい。5重量%以上では塩
析効果か杆しく、系が不安定となり、リン脂質が界面活
性剤として機能しなくなる傾向がある。
If the amount is less than 0.0 IEli, 1) I-(buffering effect is small, +) H decreases over time, phospholipid hydrolysis is promoted, and white turbidity is likely to occur. If it exceeds 5% by weight, the salting-out effect tends to be severe, the system becomes unstable, and the phospholipid tends not to function as a surfactant.

リン脂質と電解質との構成比率としては、リン脂質1に
対し電解質0.01=0.5の割合゛が系の安定性の点
てよい。
Regarding the composition ratio of phospholipid and electrolyte, a ratio of 1 phospholipid to 0.01 electrolyte=0.5 is good in terms of system stability.

また、上記電解質:まp I−15、5〜8.6の範囲
で配合されることが水溶液中でのリン脂質の加水分解を
防ぐき味で効果的である。l)Hが上記pHの範囲外で
は水溶液かにごりや白濁を生じfコリ、系が分離しrコ
リする傾向がある。また、pIIが8.6を超えた場合
、皮膚に対する一次刺激による皮膚障害が生じやすいの
で適当でない。
In addition, blending the above electrolyte in a range of 5 to 8.6 is effective in preventing hydrolysis of phospholipids in an aqueous solution. l) When H is outside the above pH range, the aqueous solution tends to become cloudy or cloudy, leading to stiffness and separation of the system, causing stiffness. Furthermore, if pII exceeds 8.6, it is not suitable because it tends to cause skin damage due to primary irritation to the skin.

本発明に用いろ透明性水溶液には、目的に応じ低級脂肪
族アルコール(例えばエタノール、プロピルアルコール
、イソプロピルアルコール等)、多価アルコール(例え
ばプロピレングリコール、1.3−ブタンジオール、工
、ヂレングリコール、ポリエチレングリコール、グリセ
リン等)、水溶性物質(例、コンドロイチン硫酸ナトリ
ウム、ヒアルロン酸ナトリウム、パンテチン、PCAソ
ーダ、クインンードガム等)、油溶性物質(例、ビタミ
ンE、ビタミンA等)ζどを配合してもよい。
Depending on the purpose, the transparent aqueous solution used in the present invention may contain lower aliphatic alcohols (e.g., ethanol, propyl alcohol, isopropyl alcohol, etc.), polyhydric alcohols (e.g., propylene glycol, 1,3-butanediol, dilene glycol, etc.). , polyethylene glycol, glycerin, etc.), water-soluble substances (e.g., sodium chondroitin sulfate, sodium hyaluronate, pantethine, PCA soda, Quinund gum, etc.), and oil-soluble substances (e.g., vitamin E, vitamin A, etc.). Good too.

まノニ、現水性界性剤は、安全性面の点からこれを含合
さ仕す、あるいはその使用を抑えることが望ましい。
From the viewpoint of safety, it is desirable to include a water-based surfactant or to suppress its use.

本発明のリン脂質を安定に配合する方法によって得られ
るリン脂質含有の透明性水溶液の調製は、常法により行
うことができるが、例えば、リン脂質と低板脂肪族アル
コールとを溶解し、こ1−、に、別に溶解した電解質を
含有するJ川水溶液からなる水相をpH5,5〜8.6
の範囲において添加し、これらを可溶化せしめることに
よって調製できる。
A transparent aqueous solution containing phospholipids obtained by the method of stably blending phospholipids of the present invention can be prepared by a conventional method, but for example, by dissolving phospholipids and a low lamellar aliphatic alcohol, 1-, the aqueous phase consisting of a J River aqueous solution containing a separately dissolved electrolyte was adjusted to pH 5.5 to 8.6.
It can be prepared by adding these in the following range and solubilizing them.

この可溶化に際しては、攪拌、加圧処理、超音波処理等
の技術手段を適宜用いることができる。
For this solubilization, technical means such as stirring, pressure treatment, and ultrasonic treatment can be used as appropriate.

かくして得られたリン脂質含有水溶液は、透明〜半透明
の外観を呈し、リン脂質は可溶化剤として働き、脂肪油
、油溶性ビタミン、香料を適当量に加えても液は濁らず
、またリン脂質自体が皮膚に対して柔軟、平滑性を与え
る効果を有するものである。また、このリン脂質を含有
した透明性水溶液は、ローションやゲル溶液として用い
ることができ、エマルジョン系の乳化物その他各種の剤
型からなる系に添加して応用した製品を得ることができ
る。
The phospholipid-containing aqueous solution obtained in this way has a transparent to translucent appearance; the phospholipid acts as a solubilizer, and even when appropriate amounts of fatty oil, oil-soluble vitamins, and fragrances are added, the solution does not become cloudy; Lipid itself has the effect of imparting softness and smoothness to the skin. In addition, this transparent aqueous solution containing phospholipids can be used as a lotion or gel solution, and can be added to emulsion-based emulsions and other systems of various dosage forms to obtain applied products.

次に、本発明に係る電解質を用いたリン脂質を安定に配
合する方法について実験した結果を述べる。実験は、リ
ン脂質を含有した透明性可溶化系水溶液での40℃6ケ
月放置による促進試験を以て行った。
Next, the results of an experiment on a method for stably blending phospholipids using an electrolyte according to the present invention will be described. The experiment was carried out using an accelerated test in which a transparent solubilizing aqueous solution containing phospholipids was left at 40°C for 6 months.

(試料) 実験に用いた可溶化系の試料は、精製大豆リン脂質0.
5重量%エタノール10.0重量%、防腐剤(Pメチル
安息呑酸エステル)適徽からなる透明性水溶液を50℃
、30分間混合溶解し、これに任意のpHに調整する為
に各種電解質を所定量加えたイオン交換水を全量が10
0重量%となるように加えて攪拌して得られた透明性可
溶化系水溶液を用いた。この際、精製大豆リン脂質は、
フォスファチジルコリン (rPcJと略)80%、フ
ォスファチジエタノールアミン15%、リゾレシチン5
%を含有したしのである。
(Sample) The solubilized sample used in the experiment was purified soybean phospholipid 0.
A transparent aqueous solution consisting of 5% by weight ethanol, 10.0% by weight and a preservative (P-methylbenzoic acid ester) was heated at 50°C.
, mix and dissolve for 30 minutes, and add ion-exchanged water to which a predetermined amount of various electrolytes was added to adjust the pH to a desired pH.
A transparent solubilized aqueous solution obtained by adding and stirring the solution to a concentration of 0% by weight was used. At this time, purified soybean phospholipids are
Phosphatidylcholine (abbreviated as rPcJ) 80%, Phosphatidiethanolamine 15%, Lysolecithin 5
It contains %.

(実験方法) 表−■に示される調製した電解質を含有するリン脂質可
溶化系の試料■〜@を各々40°Cで6ケ月放置し、実
験開始時の各試料と6ケ月放置後の各試料のp I−[
、精製大豆リン脂質中における「PC」の残存量(液体
クロマトグラフ法による)および外観を比較した。その
結果を後記表−■に示す。
(Experimental method) Samples of the phospholipid solubilized system containing the prepared electrolytes shown in Table -■ were left at 40°C for 6 months. Sample p I-[
The residual amount (by liquid chromatography) and appearance of "PC" in purified soybean phospholipids were compared. The results are shown in Table-■ below.

(評fJIiの結果) 表−■より、試料■と■のようハpHが非常に低い場合
を除1き、実験開始時においていずれも透明の外観を星
しており、電解質添加による安定化かはかふれている。
(Results of evaluation fJIi) From Table -■, except for samples ■ and ■ where the pH is very low, all of them had a transparent appearance at the start of the experiment, which may be due to stabilization due to electrolyte addition. It's faded.

また、40°C6ケ月放置後においては、試料■は白濁
、試料■は上1mへ油滴が分層、試r′1のと■及びコ
ントロールの試料・■は浮、ω物を発生し、外観的にい
ずれも雉がみられ、しから7pc4の残存量が著しく低
下している。な、お辺衝作用を何する電解質を加えてい
ないコントロール1偽1よ、当初のI) t[か・1.
80という弱酸性であり1こに乙かかわらず、!10°
06ケ月後にはpH、t 、 :32にl;す、大幅r
jpH低下を起こしているのか判る。これに対し、p 
Hが5.5〜8.6の範囲にある試Fl■、■、■、■
〜・ルは、「PC」の残(? 771の低下が少なく、
透明外観をイイC持し、良好t工拮果を得ている。従っ
て、本発明力く、この範囲のI)11に、r;いて、最
乙電解質添加による透明性水溶液中てJ)リン脂質の経
時安定性を’1(ff持することか理解5メ−るらのて
めるっ また、ホウ酸、コハク酸ナトリウム、リン酸二水素カリ
ウム、リン酸二水素ナトリウム、ボリアグリル酸カリウ
ム等のpH緩新作用を有する他の電解質についても同様
に経時安定性の実験を行ったが、は望同様の結果が得ら
れた。
In addition, after being left at 40°C for 6 months, sample (■) became cloudy, sample (■) had oil droplets separated to the top 1m, sample r'1 and (2) and control sample (■) floated, and ω substances were generated. Pheasant was observed in all cases, and the remaining amount of Shishi 7pc4 was significantly reduced. Control 1 False 1, in which no electrolytes were added to have a compromising effect, compared to the original I) t[ka・1.
It has a weak acidity of 80, so regardless of whether it is 1 or 2, it is! 10°
After 0.6 months, the pH decreased significantly to 32.
It can be seen whether the pH is decreasing. On the other hand, p
Trial Fl■,■,■,■ with H in the range of 5.5 to 8.6
~・Le has a small decrease in "PC" (? 771),
It has a good transparent appearance and good performance. Therefore, the present invention emphasizes that within this range I) 11, it is understood that J) the stability of phospholipids over time in a transparent aqueous solution due to the addition of an electrolyte is maintained at 1 (ff). Similarly, other electrolytes that have a pH-reducing effect, such as boric acid, sodium succinate, potassium dihydrogen phosphate, sodium dihydrogen phosphate, and potassium boriagrilate, have been shown to be stable over time. I conducted an experiment, and the results were similar to my expectations.

次に本発明のリン脂質を安定に配合する方法により得ら
れた透明性水溶液の実施例を示す。(重量%) 実施例1 可溶化ローション L香  料                    
   0.02−2工、、!2+F、1.つ、    
  。、1レオン交換水      加えて全[100
Aと水相のBとを各々別:こ溶解=t、、PH6,81
においでAにBを添加して可溶化せしめ:A製した。
Next, examples of transparent aqueous solutions obtained by the method of stably blending phospholipids of the present invention will be shown. (% by weight) Example 1 Solubilized Lotion L Fragrance
0.02-2 engineering,,! 2+F, 1. One,
. , 1 leon exchange water plus all [100
Separate A and B in the aqueous phase: Dissolution = t, PH6,81
B was added to A to solubilize it by smell: A was prepared.

この可溶化ローションは透明の外観を呈し、40℃6ケ
月放置においてら経時安定性が浸れていた。
This solubilized lotion had a transparent appearance and had excellent stability over time after being left at 40° C. for 6 months.

実施例2 可溶化ローション 1精製大豆レシチン        0.2□ lエタノール            8.0え 一ン酸二水素ナトリウム      0.02ヨイオン
交換水      加えて全m100Aと水相のBとを
各々別に溶解し、PH7,48においてAにBを添加し
て可溶化けしめ調製した。
Example 2 Solubilized lotion 1 Purified soybean lecithin 0.2 □ l Ethanol 8.0 Sodium dihydrogen monophosphate 0.02 Ion-exchanged water In addition, total ml 100 A and aqueous phase B were dissolved separately, and the pH was adjusted to 7, In step 48, B was added to A to solubilize and tighten.

この可溶化ローションは透明の外観を呈し、40’C6
ケ月放置においてら経時安定性が量れていた。
This solubilized lotion has a transparent appearance and is 40'C6
The stability over time was determined after being left for several months.

Claims (1)

【特許請求の範囲】 1、リン脂質を含有した透明性水溶液に無機および/ま
たは有機の電解質が配合されてなることを特徴とするリ
ン脂質を安定に配合する方法。 2、電解質がpH5.5〜8.6の範囲で配合されてな
る特許請求の範囲第1項記載のリン脂質を安定に配合す
る方法。 3、電解質がpH緩衝作用を有する電解質である特許請
求の範囲第1項及び第2項記載のリン脂質を安定に配合
する方法。
[Scope of Claims] 1. A method for stably blending phospholipids, which comprises blending an inorganic and/or organic electrolyte into a transparent aqueous solution containing phospholipids. 2. A method for stably blending a phospholipid according to claim 1, wherein the electrolyte is blended at a pH in the range of 5.5 to 8.6. 3. A method for stably blending phospholipids according to claims 1 and 2, wherein the electrolyte is an electrolyte having a pH buffering effect.
JP61102140A 1986-05-06 1986-05-06 Method for blending phospholipid stably Pending JPS62263109A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP61102140A JPS62263109A (en) 1986-05-06 1986-05-06 Method for blending phospholipid stably

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61102140A JPS62263109A (en) 1986-05-06 1986-05-06 Method for blending phospholipid stably

Publications (1)

Publication Number Publication Date
JPS62263109A true JPS62263109A (en) 1987-11-16

Family

ID=14319458

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61102140A Pending JPS62263109A (en) 1986-05-06 1986-05-06 Method for blending phospholipid stably

Country Status (1)

Country Link
JP (1) JPS62263109A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01319412A (en) * 1988-05-02 1989-12-25 Henkel Kgaa Natural component-containing hair treatment preparation
WO1994009015A1 (en) * 1992-10-15 1994-04-28 Q. P. Corporation Phosphatidylcholine and process for producing the same
JPH06157283A (en) * 1992-07-24 1994-06-03 Unilever Nv Use of cosmetics composition
WO1998021215A1 (en) * 1996-11-13 1998-05-22 Q.P. Corporation Phospholipid composition

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5910511A (en) * 1982-07-07 1984-01-20 Eisai Co Ltd Aqueous solution containing fat-soluble substance
JPS62419A (en) * 1985-06-26 1987-01-06 Shiseido Co Ltd Water-soluble agent containing fat-soluble vitamin
JPS624215A (en) * 1985-07-01 1987-01-10 Shiseido Co Ltd Cosmetic

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5910511A (en) * 1982-07-07 1984-01-20 Eisai Co Ltd Aqueous solution containing fat-soluble substance
JPS62419A (en) * 1985-06-26 1987-01-06 Shiseido Co Ltd Water-soluble agent containing fat-soluble vitamin
JPS624215A (en) * 1985-07-01 1987-01-10 Shiseido Co Ltd Cosmetic

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01319412A (en) * 1988-05-02 1989-12-25 Henkel Kgaa Natural component-containing hair treatment preparation
JPH06157283A (en) * 1992-07-24 1994-06-03 Unilever Nv Use of cosmetics composition
WO1994009015A1 (en) * 1992-10-15 1994-04-28 Q. P. Corporation Phosphatidylcholine and process for producing the same
WO1998021215A1 (en) * 1996-11-13 1998-05-22 Q.P. Corporation Phospholipid composition
US6054494A (en) * 1996-11-13 2000-04-25 Q. P. Corporation Phospholipid composition

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