CN109715634B - Menin-mll相互作用的稠合二环抑制剂 - Google Patents

Menin-mll相互作用的稠合二环抑制剂 Download PDF

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Publication number
CN109715634B
CN109715634B CN201780056197.2A CN201780056197A CN109715634B CN 109715634 B CN109715634 B CN 109715634B CN 201780056197 A CN201780056197 A CN 201780056197A CN 109715634 B CN109715634 B CN 109715634B
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alkyl
hydrogen
optionally substituted
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substituents
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CN109715634A (zh
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P.R.安吉博
V.潘德
B.赫克特
D.J.科罗斯基
O.A.G.克洛勒
A.N.帕特里克
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780056197.2A 2016-09-14 2017-09-13 Menin-mll相互作用的稠合二环抑制剂 Active CN109715634B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662394291P 2016-09-14 2016-09-14
US62/394291 2016-09-14
EP16192424.6 2016-10-05
EP16192424 2016-10-05
EP17180228 2017-07-07
EP17180228.3 2017-07-07
PCT/EP2017/073001 WO2018050684A1 (en) 2016-09-14 2017-09-13 Fused bicyclic inhibitors of menin-mll interaction

Publications (2)

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CN109715634A CN109715634A (zh) 2019-05-03
CN109715634B true CN109715634B (zh) 2022-09-27

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US (2) US10611778B2 (https=)
EP (1) EP3512858B1 (https=)
JP (1) JP7033141B2 (https=)
KR (1) KR102493364B1 (https=)
CN (1) CN109715634B (https=)
AU (1) AU2017326485B2 (https=)
CA (1) CA3033020A1 (https=)
ES (1) ES2966316T3 (https=)
IL (1) IL265231B (https=)
MA (1) MA46228A (https=)
MX (1) MX389598B (https=)
TW (1) TWI753016B (https=)
WO (1) WO2018050684A1 (https=)

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TW201823249A (zh) 2018-07-01
CN109715634A (zh) 2019-05-03
KR20190046888A (ko) 2019-05-07
US10975100B2 (en) 2021-04-13
CA3033020A1 (en) 2018-03-22
EP3512858C0 (en) 2023-11-08
IL265231B (en) 2021-06-30
US10611778B2 (en) 2020-04-07
US20200172556A1 (en) 2020-06-04
MX2019002959A (es) 2019-07-04
KR102493364B1 (ko) 2023-01-27
US20190218230A1 (en) 2019-07-18
AU2017326485B2 (en) 2021-04-22
EP3512858B1 (en) 2023-11-08
JP7033141B2 (ja) 2022-03-09
TWI753016B (zh) 2022-01-21
ES2966316T3 (es) 2024-04-19
MX389598B (es) 2025-03-11
IL265231A (en) 2019-05-30
BR112019004764A2 (pt) 2019-05-28
AU2017326485A1 (en) 2019-02-21
WO2018050684A1 (en) 2018-03-22
MA46228A (fr) 2019-07-24
EP3512858A1 (en) 2019-07-24
JP2019530745A (ja) 2019-10-24

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