CN109715175A - 用于治疗脊髓损伤的多潜能干细胞衍生的少突胶质细胞祖细胞 - Google Patents

用于治疗脊髓损伤的多潜能干细胞衍生的少突胶质细胞祖细胞 Download PDF

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Publication number
CN109715175A
CN109715175A CN201780056381.7A CN201780056381A CN109715175A CN 109715175 A CN109715175 A CN 109715175A CN 201780056381 A CN201780056381 A CN 201780056381A CN 109715175 A CN109715175 A CN 109715175A
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China
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composition
cell
spinal cord
cord injury
stem cell
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CN201780056381.7A
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English (en)
Chinese (zh)
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E·D·维尔斯三世
J·S·莱布考斯基
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ASTERIAS BIOTHERAPY CORP
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ASTERIAS BIOTHERAPY CORP
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201780056381.7A 2016-09-14 2017-09-14 用于治疗脊髓损伤的多潜能干细胞衍生的少突胶质细胞祖细胞 Pending CN109715175A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662394226P 2016-09-14 2016-09-14
US62/394,226 2016-09-14
US201762449580P 2017-01-23 2017-01-23
US62/449,580 2017-01-23
US201762518591P 2017-06-12 2017-06-12
US62/518,591 2017-06-12
PCT/US2017/051677 WO2018053210A1 (en) 2016-09-14 2017-09-14 Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury

Publications (1)

Publication Number Publication Date
CN109715175A true CN109715175A (zh) 2019-05-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780056381.7A Pending CN109715175A (zh) 2016-09-14 2017-09-14 用于治疗脊髓损伤的多潜能干细胞衍生的少突胶质细胞祖细胞

Country Status (7)

Country Link
US (1) US20190262405A1 (enExample)
EP (1) EP3518945A4 (enExample)
JP (3) JP2019526584A (enExample)
CN (1) CN109715175A (enExample)
AU (1) AU2017326424B2 (enExample)
CA (1) CA3036832A1 (enExample)
WO (1) WO2018053210A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019342741B2 (en) 2018-09-19 2025-12-11 Lineage Cell Therapeutics, Inc. Methods for differentiating pluripotent stem cells in dynamic suspension culture
CA3181413A1 (en) * 2020-05-01 2021-11-04 The Children's Medical Center Corporation Compositions and methods of promoting myelination
US20240082311A1 (en) * 2021-01-28 2024-03-14 Asterias Biotherapeutics, Inc. Compositions and methods for treating spinal cord injuries

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1833021A (zh) * 2003-07-18 2006-09-13 大冢制药株式会社 少突胶质祖细胞和获得及培养它们的方法
CN1852971A (zh) * 2002-07-11 2006-10-25 加利福尼亚大学董事会 衍生自人胚胎干细胞的用于脊髓损伤的再髓鞘化和治疗的少突胶质细胞

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1852971A (zh) * 2002-07-11 2006-10-25 加利福尼亚大学董事会 衍生自人胚胎干细胞的用于脊髓损伤的再髓鞘化和治疗的少突胶质细胞
CN1833021A (zh) * 2003-07-18 2006-09-13 大冢制药株式会社 少突胶质祖细胞和获得及培养它们的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAPMAN等: "Evaluating the First-in-Human Clinical Trial of a Human Embryonic Stem Cell-Based Therapy", 《KENNEDY INSTITUTE OF ETHICS JOURNAL》 *
PRIEST等: "Preclinical safety of human embryonic stem cell-derived oligodendrocyte progenitors supporting clinical trials in spinal cord injury", 《REGEN. MED》 *
SHARP等: "Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery after Cervical Spinal Cord Injury", 《STEM CELLS》 *

Also Published As

Publication number Publication date
AU2017326424B2 (en) 2023-12-14
US20190262405A1 (en) 2019-08-29
JP2024096794A (ja) 2024-07-17
CA3036832A1 (en) 2018-03-22
AU2017326424A1 (en) 2019-04-18
JP2022130483A (ja) 2022-09-06
EP3518945A4 (en) 2020-04-22
JP2019526584A (ja) 2019-09-19
EP3518945A1 (en) 2019-08-07
WO2018053210A1 (en) 2018-03-22

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