AU2017326424B2 - Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury - Google Patents

Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury Download PDF

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Publication number
AU2017326424B2
AU2017326424B2 AU2017326424A AU2017326424A AU2017326424B2 AU 2017326424 B2 AU2017326424 B2 AU 2017326424B2 AU 2017326424 A AU2017326424 A AU 2017326424A AU 2017326424 A AU2017326424 A AU 2017326424A AU 2017326424 B2 AU2017326424 B2 AU 2017326424B2
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cells
composition
spinal cord
cord injury
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AU2017326424A1 (en
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Jane S. Lebkowski
Edward D. Wirth III
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Asterias Biotherapeutics Inc
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Asterias Biotherapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2017326424A 2016-09-14 2017-09-14 Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury Active AU2017326424B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662394226P 2016-09-14 2016-09-14
US62/394,226 2016-09-14
US201762449580P 2017-01-23 2017-01-23
US62/449,580 2017-01-23
US201762518591P 2017-06-12 2017-06-12
US62/518,591 2017-06-12
PCT/US2017/051677 WO2018053210A1 (en) 2016-09-14 2017-09-14 Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury

Publications (2)

Publication Number Publication Date
AU2017326424A1 AU2017326424A1 (en) 2019-04-18
AU2017326424B2 true AU2017326424B2 (en) 2023-12-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017326424A Active AU2017326424B2 (en) 2016-09-14 2017-09-14 Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury

Country Status (7)

Country Link
US (1) US20190262405A1 (enExample)
EP (1) EP3518945A4 (enExample)
JP (3) JP2019526584A (enExample)
CN (1) CN109715175A (enExample)
AU (1) AU2017326424B2 (enExample)
CA (1) CA3036832A1 (enExample)
WO (1) WO2018053210A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12365872B2 (en) 2018-09-19 2025-07-22 Lineage Cell Therapeutics, Inc. Methods for differentiating pluripotent stem cells in dynamic suspension culture
CN115667503A (zh) * 2020-05-01 2023-01-31 儿童医疗中心有限公司 促进髓鞘化的组合物和方法
EP4284397A4 (en) * 2021-01-28 2025-04-16 Asterias Biotherapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATING SPINAL CORD INJURIES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285415B2 (en) * 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
AR046076A1 (es) * 2003-07-18 2005-11-23 Otsuka Pharma Co Ltd Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHARP ET AL.: "Human Embryonic Stem Cell -Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery after Cervical Spinal Cord Injury", STEM CELLS, vol. 28, no. 1, January 2010 (2010-01-01), pages 152 - 163, XP055499221 *

Also Published As

Publication number Publication date
AU2017326424A1 (en) 2019-04-18
US20190262405A1 (en) 2019-08-29
EP3518945A4 (en) 2020-04-22
CA3036832A1 (en) 2018-03-22
WO2018053210A1 (en) 2018-03-22
JP2019526584A (ja) 2019-09-19
JP2022130483A (ja) 2022-09-06
CN109715175A (zh) 2019-05-03
JP2024096794A (ja) 2024-07-17
EP3518945A1 (en) 2019-08-07

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