CN109700957A - A kind of avermectin Chinese herbal medicine extract cream and preparation method thereof for treating dog acarid disease - Google Patents
A kind of avermectin Chinese herbal medicine extract cream and preparation method thereof for treating dog acarid disease Download PDFInfo
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Abstract
The invention discloses a kind of avermectin Chinese herbal medicine extract creams and preparation method thereof for treating dog acarid disease, belong to pharmaceutic preparation for livestock technical field.Cream of the invention is made of avermectin, Chinese herbal medicine extract, vitamin E, stearic acid, albolene, atoleine, polysorbas20, azone, sodium carboxymethylcellulose, ethyl-para-hydroxybenzoate, purified water.This product cream has many advantages, such as that external application is easy to use, property is stable, helminth is not likely to produce drug resistance, clinical efficacy is good, uneasy to recur.Emulsifiable paste uniform and smooth of the present invention, preparation process are simple, it is easy to accomplish industrialization can be used for the parasitic diseases infection such as veterinary clinic treatment acarid.
Description
Technical field
The invention belongs to pharmaceutic preparation for livestock fields, can be used for the parasitic diseases such as dog clinical treatment acarid disease, specifically
It is a kind of avermectin Chinese herbal medicine extract cream and preparation method thereof for treating dog acarid disease.
Background technique
Dog skin disease is a kind of common disease in cultivation, it not only influences the body appearance of sick dog, it is often more important that it is serious
Upset being normally carried out for sick dog daily life.Dog skin disease is many kinds of, and the cause of disease is complicated, and disease incidence is high.Studies have shown that skin disease
Account for about common clinical case 20% in dog outpatient service, wherein the infection due to caused by acarid accounts for 50-90%.Therefore, clinic needs out
Send out efficient, low toxicity, anti-drug resistance, dog easy to use antimite drug.
Avermectin is one group of 16 membered macrolide antibiotic, has the characteristics that efficient, low toxicity, pest-resistant spectrum are wide, extensively
The general arthropods helminth for the intracorporal nematode of animal repelling and skin endoparasitism, action target spot are helminth aminobutyric acid
(GABA) receptor promotes release of the GABA from nerve endings, enhances the combination of receptor on GABA and cell membrane, makes into cell
Chloride ion increases, cell membrane hyperpolarization, transmits so as to cause nerve signal suppressed, causes paralysis, dead, but the drug to light not
Stablize, after fluorescent lamp treatment with irradiation, half-life period is reduced to 3h, and with being widely used for avermectin, helminth slowly produces it
Raw drug resistance, leads to the reduction of clinical drug curative effect, and rear recurrent exerbation is even completely ineffective.Currently, obtaining Ministry of Agriculture's approval
Produce and sell license is only limitted to avermectin tablet, capsule, injection etc..
Chinese herbal medicine is rich in various active substance, and most of Chinese herbal medicine usually all has preferable antibiotic property, antibiotic property
It is widely used.But the application study in terms of Chinese herbal medicine is used for anti-dog acarid drug is also less.The present invention is by AVM hereinafter
Compound cream agent is made in rhzomorph and Chinese medical extract, can enhance its stability, is applied to veterinary clinic, and having reduces helminth
Drug resistance generates, and enhances insect resistant effect, reduces recurrence rate, improves the economic benefit of veterinary clinic therapeutic effect and cultivation, has
Vast market prospect.
Summary of the invention
Aiming at the problems existing in the prior art, the present invention provides a kind of avermectin Chinese herbal medicines for treating dog acarid disease
Extract cream.This product cream is with external application is easy to use, property is stable, helminth is not likely to produce drug resistance, does not allow
It is easy to recur, the advantages that clinical efficacy is good.Emulsifiable paste uniform and smooth of the present invention, preparation process are simple, it is easy to accomplish industrialization can be used for
The infection of the parasitic diseases such as canine clinical treatment acarid.
The present invention also provides a kind of preparation methods of avermectin Chinese herbal medicine extract cream for treating dog acarid disease.
The invention adopts the following technical scheme:
A kind of avermectin Chinese herbal medicine extract cream for treating dog acarid disease, it is by the raw material system of following parts by weight
At: avermectin 2-8, Chinese herbal medicine extract 1-5, vitamin E 0.05-0.2, stearic acid 10-15, albolene 13-20, liquid
Paraffin 15-35, polysorbas20 3-5, azone 0.1-2, sodium carboxymethylcellulose 0.1-1.5, ethyl-para-hydroxybenzoate 0.05-
0.20, purified water 9.1-55.7；The Chinese herbal medicine extract parts by weight composition are as follows: honeysuckle 40, radix scutellariae 40, dandelion 40, hundred
Portion 30, Chinese gall 30, Fructus Forsythiae 70, peppermint 20, licorice 10.
A kind of preparation method of avermectin Chinese herbal medicine extract cream that treating dog acarid disease, it includes following step
It is rapid:
(1) it takes formula ratio avermectin and is micronized, cross 60-100 mesh；
(2) preparation of Chinese herbal medicine extract: weighing Chinese herbal medicine and crush through pulverizer, crosses 60-100 mesh, is uniformly mixed, sets
Multifunction supersonic extractor is added purified water in 1:5-12 ratio, impregnates 1-2h, 70-100 DEG C is heated to, in 200-400W item
Under part, ultrasonic extraction 0.25-1.0h is extracted 2-3 times, combined extract, filtering, and 60-80 DEG C uses Rotary Evaporators, by filtrate
Being condensed into relative density is 1.1-1.3, is dried in vacuo, and is crushed, and crosses 60-100 mesh to get Chinese herbal medicine extract；
(3) recipe quantity stearic acid, vitamin E, albolene, atoleine are weighed in beaker, heating water bath keeps it molten
Change, magnetic agitation is uniform, for oily phase；
(4) recipe quantity polysorbas20, ethyl-para-hydroxybenzoate, azone, sodium carboxymethylcellulose and purified water are weighed in burning
In cup, heating water bath, magnetic agitation is uniform, is water phase；
(5) water phase is added slowly to oily phase under the conditions of magnetic agitation, is then respectively adding Chinese herbal medicine extract, Avermectin
Element is uniformly mixed, and filling, Co 60 ray sterilizing is to get product.
Temperature is 70-90 DEG C when vacuum drying in the step (2), time 24-48h.
Oily phase, heated aqueous temperature are 65-90 DEG C in the step (3) and step (4)；Mixing speed is 200-1000r/
min。
The beneficial effects of the present invention are: avermectin Chinese herbal medicine extract cream of the invention be with avermectin, in
Herb extracts are that main ingredient is equipped with the cream that excipient substance is prepared, and have good work to epizoons such as dog acariasis
With, be equipped with Chinese herbal medicine extract, to the parasitic diseases such as acariasis have apparent therapeutic effect, can be used for preventing and treating the body surfaces such as dog acariasis
Helminth, and more after without recurrence.Preparation process of the present invention is simple, and production cost is low, and stability is high, it is easy to accomplish industrialization makes
With conveniently, there is high application value.
Specific embodiment
The present invention is described in further detail combined with specific embodiments below.
Embodiment 1
The formula that the present invention treats the avermectin Chinese herbal medicine extract cream of dog acarid disease is as follows:
Prescription (parts by weight)
It is of the present invention treatment dog acarid disease avermectin Chinese herbal medicine cream the preparation method is as follows:
(1) avermectin is micronized, is sieved with 100 mesh sieve；
(2) Chinese herbal medicine extract is prepared by following methods: weighing Chinese herbal medicine (honeysuckle 40g, radix scutellariae
40, dandelion 40g, tuber of stemona 30g, Chinese gall 30g, Fructus Forsythiae 70g, peppermint 20g, licorice 10g), it is crushed through pulverizer, crosses 100
Mesh is uniformly mixed, sets multifunction supersonic extractor, and purified water is added in 1:8 ratio, impregnates 1h, 90 DEG C is heated to, in 300W
Under the conditions of, ultrasonic extraction 0.5h is extracted 2 times, combined extract, filtering, and 60 DEG C use Rotary Evaporators, and filtrate is condensed into phase
It is 1.1,90 DEG C to density to be dried in vacuo for 24 hours, crushes, sieve with 100 mesh sieve；Up to Chinese herbal medicine extract；
(3) recipe quantity stearic acid, vitamin E, albolene, atoleine are weighed in beaker, 85 DEG C of water-bath heating make
It is melted, and 600r/min magnetic agitation is uniform, for oily phase；
(4) recipe quantity polysorbas20, ethyl-para-hydroxybenzoate, azone, sodium carboxymethylcellulose and purified water are weighed in burning
In cup, 75 DEG C of heating water bath, 500r/min magnetic agitation is uniform, is water phase；
(5) water phase is added slowly to oily phase under the conditions of magnetic agitation, is then respectively adding Chinese herbal medicine extract, Avermectin
Element, 400r/min magnetic agitation are uniformly mixed, and filling, Co 60 ray sterilizing is to get product.
Embodiment 2
The formula that the present invention treats the avermectin Chinese herbal medicine extract cream of dog acarid disease is as follows:
Prescription (parts by weight)
Avermectin Chinese herbal medicine cream of the present invention the preparation method is as follows:
(1) avermectin is micronized, crosses 80 meshes；
(2) Chinese herbal medicine extract is prepared by following methods: weighing Chinese herbal medicine (honeysuckle 40g, radix scutellariae
40, dandelion 40g, tuber of stemona 30g, Chinese gall 30g, Fructus Forsythiae 70g, peppermint 20g, licorice 10g), it is crushed through pulverizer, crosses 60 mesh
Sieve is uniformly mixed, sets multifunction supersonic extractor, and purified water is added in 1:10 ratio, impregnates 2h, 100 DEG C is heated to, in 240W
Under the conditions of, ultrasonic extraction 0.25h is extracted 3 times, combined extract, filtering, and 70 DEG C use Rotary Evaporators, and filtrate is condensed into
Relative density is 1.2,60 DEG C of vacuum drying 48h, is crushed, and crosses 80 meshes to get Chinese herbal medicine extract；
(3) recipe quantity stearic acid, vitamin E, albolene, atoleine are weighed in beaker, 90 DEG C of heating water baths make
It is melted, and 1000r/min magnetic agitation is uniform, for oily phase；
(4) recipe quantity polysorbas20, ethyl-para-hydroxybenzoate, azone, sodium carboxymethylcellulose and purified water are weighed in burning
In cup, 65 DEG C of heating water baths, 200r/min magnetic agitation is uniform, is water phase；
(5) water phase is added slowly to oily phase under the conditions of magnetic agitation, is then respectively adding Chinese herbal medicine extract, Avermectin
Element, 300r/min magnetic agitation are uniformly mixed, and filling, Co 60 ray sterilizing is to get product.
Embodiment 3
The formula that the present invention treats the avermectin Chinese herbal medicine extract cream of dog acarid disease is as follows:
Prescription (parts by weight)
Avermectin Chinese herbal medicine cream of the present invention the preparation method is as follows:
(1) avermectin is micronized, crosses 60 meshes；
(2) Chinese herbal medicine extract is prepared by following methods: weighing Chinese herbal medicine (honeysuckle 40g, radix scutellariae
40, dandelion 40g, tuber of stemona 30g, Chinese gall 30g, Fructus Forsythiae 70g, peppermint 20g, licorice 10g), it is crushed through pulverizer, crosses 60 mesh
Sieve is uniformly mixed, sets multifunction supersonic extractor, and purified water is added in 1:5 ratio, impregnates 1h, 70 DEG C is heated to, in 360W item
Under part, ultrasonic extraction 0.25h is extracted 2 times, combined extract, filtering, and 80 DEG C use Rotary Evaporators, and filtrate is condensed into phase
It is 1.3,70 DEG C of vacuum drying 30h to density, crushes, crosses 60 meshes to get Chinese herbal medicine extract；
(3) recipe quantity stearic acid, vitamin E, albolene, atoleine are weighed in beaker, 80 DEG C of heating water baths make
It is melted, and 800r/min magnetic agitation is uniform, for oily phase；
(4) recipe quantity polysorbas20, ethyl-para-hydroxybenzoate, azone, sodium carboxymethylcellulose and purified water are weighed in burning
In cup, 65 DEG C of heating water baths, 400r/min magnetic agitation is uniform, is water phase；
(5) water phase is added slowly to oily phase under the conditions of magnetic agitation, is then respectively adding Chinese herbal medicine extract, Avermectin
Element, 500r/min magnetic agitation are uniformly mixed, and filling, Co 60 ray sterilizing is to get product.
Embodiment 4
The formula that the present invention treats the avermectin Chinese herbal medicine extract of dog acarid disease is as follows:
Prescription (parts by weight)
Avermectin Chinese herbal medicine cream of the present invention the preparation method is as follows:
(1) avermectin is micronized, is sieved with 100 mesh sieve；
(2) Chinese herbal medicine extract is prepared by following methods: weighing Chinese herbal medicine (honeysuckle 40g, radix scutellariae
40, dandelion 40g, tuber of stemona 30g, Chinese gall 30g, Fructus Forsythiae 70g, peppermint 20g, licorice 10g), it is crushed through pulverizer, crosses 100
Mesh is uniformly mixed, sets multifunction supersonic extractor, and purified water is added in 1:12 ratio, impregnates 2h, is heated to 100 DEG C,
Under the conditions of 400W, ultrasonic extraction 1h is extracted 3 times, combined extract, filtering, and 70 DEG C use Rotary Evaporators, and filtrate is condensed into
Relative density is 1.25,80 DEG C and is dried in vacuo for 24 hours, crushes, sieves with 100 mesh sieve to get Chinese herbal medicine extract；
(3) recipe quantity stearic acid, vitamin E, albolene, atoleine are weighed in beaker, 90 DEG C of heating water baths make
It is melted, and 700r/min magnetic agitation is uniform, for oily phase；
(4) recipe quantity polysorbas20, ethyl-para-hydroxybenzoate, azone, sodium carboxymethylcellulose and purified water are weighed in burning
In cup, 70 DEG C of heating water baths, 500r/min magnetic agitation is uniform, is water phase；
(5) water phase is added slowly to oily phase under the conditions of magnetic agitation, is then respectively adding Chinese herbal medicine extract, Avermectin
Element, 600r/min magnetic agitation are uniformly mixed, and filling, Co 60 ray sterilizing is to get product.
Embodiment 5
The formula that the present invention treats the avermectin Chinese herbal medicine extract cream of dog acarid disease is as follows:
Prescription (parts by weight)
Avermectin Chinese herbal medicine cream of the present invention the preparation method is as follows:
(1) avermectin is micronized, crosses 80 meshes；
(2) Chinese herbal medicine extract is prepared by following methods: weighing Chinese herbal medicine (honeysuckle 40g, radix scutellariae
40, dandelion 40g, tuber of stemona 30g, Chinese gall 30g, Fructus Forsythiae 70g, peppermint 20g, licorice 10g), it is crushed through pulverizer, crosses 80 mesh
Sieve is uniformly mixed, sets multifunction supersonic extractor, and purified water is added in 1:9 ratio, impregnates 1.5h, is heated to 100 DEG C,
Under the conditions of 300W, ultrasonic extraction 0.5h is extracted 2 times, combined extract, filtering, and 80 DEG C use Rotary Evaporators, and filtrate is concentrated
It is 1.15,85 DEG C of vacuum drying 40h at relative density, crushes, crosses 80 meshes to get Chinese herbal medicine extract；
(3) recipe quantity stearic acid, vitamin E, albolene, atoleine are weighed in beaker, 80 DEG C of heating water baths make
It is melted, and 900r/min magnetic agitation is uniform, for oily phase；
(4) recipe quantity polysorbas20, ethyl-para-hydroxybenzoate, azone, sodium carboxymethylcellulose and purified water are weighed in burning
In cup, 80 DEG C of heating water baths, 300r/min magnetic agitation is uniform, is water phase；
(5) water phase is added slowly to oily phase under the conditions of magnetic agitation, is then respectively adding Chinese herbal medicine extract, Avermectin
Element, 700r/min magnetic agitation are uniformly mixed, and filling, Co 60 ray sterilizing is to get product.
Comparative example 1
A kind of avermectin Chinese herbal medicine extract cream is formulated and the preparation method is the same as that of Example 1, unlike: in
Herb extracts are equivalent honeysuckle.
Comparative example 2
A kind of avermectin Chinese herbal medicine extract cream is formulated and the preparation method is the same as that of Example 1, unlike: in
Herb extracts are equivalent radix scutellariae.
Comparative example 3
A kind of avermectin Chinese herbal medicine extract cream is formulated and the preparation method is the same as that of Example 1, unlike: in
Herb extracts are equivalent dandelion.
Comparative example 4
A kind of avermectin Chinese herbal medicine extract cream is formulated and the preparation method is the same as that of Example 1, unlike: in
Herb extracts are the equivalent tuber of stemona.
Comparative example 5
A kind of avermectin Chinese herbal medicine extract cream is formulated and the preparation method is the same as that of Example 1, unlike: in
Herb extracts are equivalent Chinese gall.
Comparative example 6
A kind of avermectin Chinese herbal medicine extract cream is formulated and the preparation method is the same as that of Example 1, unlike: in
Herb extracts are equivalent Fructus Forsythiae.
Comparative example 7
A kind of avermectin Chinese herbal medicine extract cream is formulated and the preparation method is the same as that of Example 1, unlike: in
Herb extracts are equivalent peppermint.
Comparative example 8
A kind of avermectin Chinese herbal medicine extract cream is formulated and the preparation method is the same as that of Example 1, unlike: in
Herb extracts are equivalent licorice.
One, avermectin Chinese herbal medicine extract cream stability test
1 materials and methods
1.1 test drug
By prepared by embodiment 1 treat dog acarid disease avermectin Chinese herbal medicine extract cream 3 batches (171026,
171027,171028), control avermectin cream 3 batches (171029,171030,171031) is removed using with the formula of embodiment 1
Without cream made of raw material identical outside Chinese herbal medicine extract.
1.2 test method
Avermectin Chinese herbal medicine extract cream of the present invention and reference examples are subjected to light durability test (4500 respectively
± 500LX) 10 days, accelerated test (temperature is 40 DEG C ± 2 DEG C and relative humidity be 75% ± 5%) 6 months, long term test it is (warm
Degree is 25 DEG C ± 2 DEG C and relative humidity is 60% ± 10%) 12 months, it investigates avermectin Chinese herbal medicine extract cream and stablizes
Property.
2 test results
Test result is shown in Table 1-3.
1 acceleration by light test result of table
The warm and humid accelerated test result of table 2
3 long-term stable experiment result of table
Test result show the present invention treat dog acarid disease avermectin Chinese herbal medicine extract cream appearance character,
Relative amount changes less, compared with compareing avermectin cream, shows higher stability.
Two, therapeutic effect of the avermectin Chinese herbal medicine cream to dog acarid disease
1 materials and methods
1.1 test drug
Avermectin Chinese herbal medicine extract cream prepared by embodiment 1-5 and comparative example 1-8.
1.2 experimental animal
150 3-5 monthly age dogs, artificial challenge itch mite are selected in certain dog cultivation base, clinical manifestation pruitus is lost hair or feathers,
Pachyderma has crust, checks through laboratory, is diagnosed as itch mite infection.
1.3 test method
Experimental animal is divided into 15 groups and is numbered respectively for 1-15, every group 10, cropping at 1~2cm of affected part and surrounding,
In the 1st group be blank control group, do not use drug；2nd group is positive controls, uses commercially available avermectin aerosol；3-7
Group is test group, daily to smear once using the product of 1-5 of the embodiment of the present invention, is used continuously 10 days；The use pair of 8-15 group
The product of ratio 1-8, it is daily to smear primary, continuous use 10 days.
1.4 curative effect judging standard
(1) be completely recovered: symptom disappears, and affected part regenerates virgin wool.
(2) effectively: symptom, which mitigates, to disappear.
(3) invalid: symptom does not mitigate, shows pruitus, depilation, and pachyderma has incrustation.
(4) it recurs: recurrence in symptom disappearance one week, and it is increasingly severe over time.2 test results
It the results are shown in Table 4.
4 avermectin Chinese herbal medicine cream of table is to dog acarid disease therapeutic effect
Note: efficient (containing the rate of being completely recovered) (%)+inefficiency (%)=100%；Efficient (%)=complete cure rate
(%)+recurrence rate (%)
As shown in table 4, it can be seen that the avermectin Chinese herbal medicine for the treatment of dog acarid disease of the invention is extracted from 3-7 group data
Object cream is to dog mite treatment significant effect, total effective rate 100%, and more after without recurrence；And positive controls individually make
After commercially available avermectin aerosol, although dog total effective rate reaches 90%, high recurrence rate reaches 40%, this is mainly due to
As after being widely used of all kinds of antibiotic, helminth generates drug resistance enhancing, clinical drug effect is caused to reduce.Meanwhile from 8-15
It is also that curative effect is little, and several herbal raw materials are matched to the therapeutic effect of dog acarid that the data of group, which can be seen that single a herb,
It is used in conjunction with after 5 with avermectin, achievees the effect that cure dog acarid completely, and none rear recurrence.In addition, of the invention
Cream stability is good, has many advantages, such as that easy to use, property is stable, effect is fast, good effect, uneasy to recur, and animal doctor can be improved
Clinical therapeutic efficacy has a vast market foreground.
Claims (4)
1. a kind of avermectin Chinese herbal medicine extract cream for treating dog acarid disease, which is characterized in that it is by following weight
The raw material of part is made: avermectin 2-8, Chinese herbal medicine extract 1-5, vitamin E 0.05-0.2, stearic acid 10-15, Bai Fanshi
Woods 13-20, atoleine 15-35, polysorbas20 3-5, azone 0.1-2, sodium carboxymethylcellulose 0.1-1.5, P-hydroxybenzoic acid
Ethyl ester 0.05-0.20, purified water 9.1-55.7；The Chinese herbal medicine extract parts by weight composition are as follows: honeysuckle 40, radix scutellariae 40, Pu
Public English 40, the tuber of stemona 30, Chinese gall 30, Fructus Forsythiae 70, peppermint 20, licorice 10.
2. a kind of preparation method of the avermectin Chinese herbal medicine extract cream for the treatment of dog acarid disease described in claim 1,
It is characterized in that, it the following steps are included:
(1) it takes formula ratio avermectin and is micronized, cross 60-100 mesh；
(2) preparation of Chinese herbal medicine extract: weighing Chinese herbal medicine and crush through pulverizer, crosses 60-100 mesh, is uniformly mixed, sets more function
Energy ultrasonic extractor is added purified water in 1:5-12 ratio, impregnates 1-2h, be heated to 70-100 DEG C, under the conditions of 200-400W,
Ultrasonic extraction 0.25-1.0h is extracted 2-3 times, combined extract, filtering, and 60-80 DEG C uses Rotary Evaporators, and filtrate is concentrated
It is 1.1-1.3 ointment at relative density, vacuum drying crushes to get Chinese herbal medicine extract；
(3) recipe quantity stearic acid, vitamin E, albolene, atoleine are weighed in beaker, heating water bath makes its fusing,
Magnetic agitation is uniform, for oily phase；
(4) recipe quantity polysorbas20, ethyl-para-hydroxybenzoate, azone, sodium carboxymethylcellulose and purified water are weighed in beaker,
Heating water bath, magnetic agitation is uniform, is water phase；
(5) water phase is added slowly to oily phase under the conditions of magnetic agitation, is then respectively adding Chinese herbal medicine extract, avermectin,
It is uniformly mixed, filling, Co 60 ray sterilizing is to get product.
3. the preparation method of the avermectin Chinese herbal medicine extract cream for the treatment of dog acarid disease according to claim 2,
It is characterized in that, temperature is 70-90 DEG C when vacuum drying in the step (2), time 24-48h.
4. the preparation method of the avermectin Chinese herbal medicine extract cream for the treatment of dog acarid disease according to claim 2,
It is characterized in that, oily phase, heated aqueous temperature are 65-90 DEG C in the step (3) and step (4)；Mixing speed is 200-
1000r/min。
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| CN201910193993.1A CN109700957B (en) | 2019-03-14 | 2019-03-14 | Abamectin Chinese herbal medicine extract cream for treating dog acariasis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115607586A (en) * | 2020-04-24 | 2023-01-17 | 珠海岐微生物科技有限公司 | Application of dandelion and monomer compound thereof in mite killing |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158724A (en) * | 1996-10-30 | 1997-09-10 | 王玉万 | Veterinary antiparasitic lincture contg. avermectin or invermectin |
| US20100093652A1 (en) * | 2006-10-12 | 2010-04-15 | Topaz Pharmaceuticals Inc. | Preservative System for Emulsion-Based Therapeutic Topical Formulations |
| CN105920183A (en) * | 2016-05-27 | 2016-09-07 | 芜湖福民生物药业有限公司 | Abamectin dermatitis ointment and preparation method thereof |
-
2019
- 2019-03-14 CN CN201910193993.1A patent/CN109700957B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158724A (en) * | 1996-10-30 | 1997-09-10 | 王玉万 | Veterinary antiparasitic lincture contg. avermectin or invermectin |
| US20100093652A1 (en) * | 2006-10-12 | 2010-04-15 | Topaz Pharmaceuticals Inc. | Preservative System for Emulsion-Based Therapeutic Topical Formulations |
| CN105920183A (en) * | 2016-05-27 | 2016-09-07 | 芜湖福民生物药业有限公司 | Abamectin dermatitis ointment and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘刚: "《常见皮肤病治疗学》", 31 July 2016, 东南大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115607586A (en) * | 2020-04-24 | 2023-01-17 | 珠海岐微生物科技有限公司 | Application of dandelion and monomer compound thereof in mite killing |
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| CN109700957B (en) | 2021-04-06 |
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