CN109700488B - External fine particle fat preparation all-in-one - Google Patents
External fine particle fat preparation all-in-one Download PDFInfo
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- CN109700488B CN109700488B CN201910125174.3A CN201910125174A CN109700488B CN 109700488 B CN109700488 B CN 109700488B CN 201910125174 A CN201910125174 A CN 201910125174A CN 109700488 B CN109700488 B CN 109700488B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000010419 fine particle Substances 0.000 title claims abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 32
- 238000005520 cutting process Methods 0.000 claims abstract description 27
- 238000000338 in vitro Methods 0.000 claims abstract description 9
- 238000005406 washing Methods 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000007789 sealing Methods 0.000 claims description 10
- 238000007599 discharging Methods 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims 1
- 238000002054 transplantation Methods 0.000 abstract description 10
- 210000000130 stem cell Anatomy 0.000 abstract description 7
- 238000007443 liposuction Methods 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 229920001296 polysiloxane Polymers 0.000 abstract description 2
- 238000000746 purification Methods 0.000 abstract description 2
- 239000002699 waste material Substances 0.000 abstract description 2
- 239000008187 granular material Substances 0.000 description 9
- 210000001789 adipocyte Anatomy 0.000 description 6
- 210000000577 adipose tissue Anatomy 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 210000003195 fascia Anatomy 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000004429 Calibre Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
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- 239000010865 sewage Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
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- External Artificial Organs (AREA)
- Crushing And Pulverization Processes (AREA)
Abstract
An in-vitro fine particle fat preparation integrated machine comprisesAn aseptic sealed cavity provided with an inlet and an outlet, wherein the inlet of the cavity is connected with a large-caliber liposuction tube (the tube diameter is more than or equal to 4mm, the side hole area is more than or equal to 10 mm) 2 ) And the outlet of the cavity is connected with the high negative pressure device through a silicone tube, and a fat particle cutting device and a washing device are arranged in the cavity. The invention solves the problems of time and labor waste in fat suction, low content of fat stem cells, easy pollution in the purification process and the like in the fat transplantation process.
Description
Technical Field
The invention relates to an in-vitro fine particle fat preparation integrated machine.
Background
The autologous fat has the advantages of abundant sources, convenient material taking, no rejection, simple operation, good filling appearance, no disease infection, no scar left after operation and the like, and is widely used in clinic, and is a common means for tissue filling and wound repair in plastic surgery. The uncertainty of their graft survival, especially long-term survival, has so far remained a major obstacle limiting their use. Improving the survival rate of fat after transplantation, especially long-term survival rate, is still a problem that needs to be solved urgently. A number of studies have shown that: at present, the volume of transplanted adipose tissue still can only be reserved by 50% -80.
Studies have shown that: in early stage of transplantation, adipose tissue is in ischemic and anoxic state, and the surrounding tissue fluid is used for providing nutrition, so that fat cells are well stored in the tissue interstitial fluid 1.5+/-0.5 mm away from the tissue interstitial fluid, and the blood vessels which are newly grown in 5 days after operation start to germinate from the periphery of the graft, but if the diameter of the fat particles exceeds 2mm, the fat cells in the center of the fat particles are limited by the dispersion distance of the tissue fluid, and the fat cells in the center of the fat particles are liquefied and necrotized due to the limitation of nutrition acquisition and oxygen. Therefore, the early acquisition of nutrition by transplanted fat in the affected area and the timely establishment of blood supply are largely dependent on fat particle diameter.
In 2001, zuk et al found mesenchymal stem cells (mesenchymal stem cells, MSCs) in adipose tissue for the first time, called adipose-derived stem cells (adicose-derived stem cells, ADSCs). Like bone marrow derived MSCs, ADSCs also have good self-renewal and multipotent differentiation potential. But the adipose-derived stem cells are more convenient to obtain, the pain is less, and more importantly, the content of the stem cells in adipose tissues is 500-1000 times of that of bone marrow. ADSCs can improve the blood vessel density in free transplanted adipose tissue on one hand in the fat transplantation process, and help the early establishment of timely and sufficient blood supply of the transplant; on the other hand, the fat cells can be differentiated, and the reduced quantity of the fat cells is supplemented, so that the survival rate of the transplanted fat is effectively improved. Increasing the ADSCs content in the transplanted fat.
Large pipe diameter (phi is more than or equal to 4mm, and the caliber area S of the side hole is more than or equal to 10 mm) 2 Tube diameter) of the liposuction needle, while the dispersion distance of the tissue fluid is limited, fat center cells are necrotized due to poor blood circulation. Thus, it is clinically accepted that small tube diameters (phi=2 mm, s=1 mm 2 ) Low negative pressure fat suction is the key to successful fat transplantation, and large-diameter fat suction tubes are not recommended for fat transplantation and fat suction.
Although the small-caliber liposuction tube has a plurality of advantages, the content of ADSCs in the sucked granular fat is low, the analysis reasons possibly relate to the fact that the ADSCs are mainly distributed around interstitial blood vessels and fascia connective tissues of adipose tissues, and the content of the ADSCs in the fat obtained by the small-caliber liposuction tube is obviously reduced compared with the content of the ADSCs in a supply area due to the characteristics of relatively compact tissues and high toughness of the blood vessels and fascia connective tissues.
Disclosure of Invention
The invention solves the defects of the prior art and provides an in-vitro fine particle fat preparation integrated machine with high fat suction efficiency and high survival rate of transplanted fat, wherein the fine particle fat refers to particle fat with particle diameter d less than 2 mm.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the utility model provides an external fine particle fat preparation all-in-one, includes a sterile seal's cavity, the cavity is equipped with import and export, the import and the heavy-calibre fat suction tube of cavity are connected, the export of cavity is connected with high negative pressure device through the silicone tube, be provided with fat granule cutting device and washing device in the cavity. The device utilizes a hospital negative pressure suction system or a conventional fat negative pressure suction device (the negative pressure value of the high negative pressure device is 0.02-0.07 Mpa), and the negative pressure suction system is connected with a silica gel tube connected with an outlet of the cavity, so that high negative pressure is formed in the cavity and at the outlet of the cavity, fat of a patient is sucked through a large-caliber fat suction tube, and the sucked large-particle fat is cut and crushed into small-particle fat through a fat particle cutting device, so that the problem of fat cell necrosis caused by overlarge fat particles is solved, the problem of too low ADSCs content in the obtained fat tissue is solved, the cell activity is ensured, and experiments also find that the clinical fat suction efficiency can be remarkably improved by adopting the large-caliber fat suction tube.
Further, the fat particle cutting device comprises a blade set arranged right below the funnel outlet for receiving fat particles in the cavity and a first motor for driving the blade set to rotate.
Further, the blade sets are axially distributed along the rotating shaft, each blade set comprises at least two blades symmetrically distributed along the rotating shaft, and the blades and the horizontal plane are provided with an included angle of 0-15 degrees, namely the blades can be parallel to the horizontal plane.
Further, the cavity is also provided with a washing device for cleaning the fat in the cavity by passing through water and a fat discharge and collection port for discharging fat, and the washing water in the cavity is discharged through a high negative pressure device at the outlet of the cavity.
Further, washing device includes water inlet and collection dish, fat granule cutting device's export and collection dish top opening intercommunication, the collection dish all around and bottom surface are filter screen, upper portion opening, the filter screen aperture of collection dish is less than the fat granule after the cutting, the bottom of collection dish is equipped with the valve and passes through pipeline and discharge and collect the mouth intercommunication, the export setting of cavity is in the outside of collection dish. And a spray head is arranged on the water inlet in the cavity body, and faces the fat particle cutting device.
Further, the bottom of the collecting tray is in an inverted cone shape.
Further, a stirring device is arranged below the collecting tray in the cavity.
Further, the stirring device comprises a stirring blade arranged in the cavity and a second motor for driving the stirring blade to rotate.
Further, a drain outlet is arranged at the bottom of the cavity.
Further, including the barrel, the barrel middle part forms the cavity, from the top down includes cutting area, collection area and stirring area in proper order in the cavity, fat granule cutting device sets up at cutting area, the collection dish sets up at collection area, the agitator sets up at stirring area.
Further, the blade is connected with a first motor output end arranged outside the cylinder body through a rotating shaft, the rotating shaft is sealed with the inner wall of the cavity body through a sealing component, and the stirring shaft of the stirring device is also sealed with the inner wall of the cavity body through the sealing component.
By adopting the device, the inherent clinical thinking that a small-caliber low-negative-pressure fat suction tube is needed when fat transplantation and fat suction is performed is changed, and through careful analysis and preliminary experimental verification, the problems faced by the current fat transplantation are solved and a brand new and complete set of fat transplantation technology is created on the basis of manufacturing the external fine-particle fat grinder. The comparison analysis shows that the small-caliber fat suction tube sucks the same volume of granular fat ADSCs content at low negative pressure and high negative pressure, and after digestion, culture and counting, the number of stem cells contained in the latter is 1.7-3 times of that of the former, so that the large-caliber and high negative pressure suction tube is more beneficial to ADSCs acquisition.
In conclusion, the invention solves the problems of time and labor waste in fat suction, low content of fat stem cells, easy pollution in the purification process and the like in the fat transplantation process.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a front view of one embodiment of a bladeset of the present invention.
Fig. 3 is a left side view of fig. 2.
Fig. 4 is a top view of fig. 2.
Fig. 5 is a front view of another embodiment of a bladeset of the present invention.
Fig. 6 is a top view of fig. 5.
In the drawing, 1, a cylinder body, 11, a fat suction port, 12 and a water inlet; 13. the negative pressure water outlet, 14, the fat discharging and collecting port, 15, the drain outlet, 21, the first motor, 22, the first motor fixing frame, 23, the first rotating shaft, 24, the blade, 25, the knife rest, 26, the first sealing piece, 27, the first transmission device, 31, the second motor, 32, the second transmission device, 33, the second sealing piece, 34, the stirring blade, 4, the collecting disc, 5, the protective net, 6, the supporting leg, 7 and the soft pipeline.
Detailed Description
The invention will be further described in detail below with reference to the drawings and examples of implementation for a better understanding of the invention, but the embodiments of the invention are not limited thereto, and the scope of protection of the invention also relates to equivalent technical means that can be conceived by a person skilled in the art based on the inventive concept.
Example 1:
as shown in FIG. 1, the embodiment is used as the core of the device and comprises a barrel 1, wherein the barrel 1 is supported on the ground through a supporting leg 6, a cavity is formed in the middle of the barrel 1, the barrel 1 is provided with a fat suction port 11, a water inlet 12, a negative pressure water outlet 13, a fat discharge collection port 14 and a drain outlet 15, the inlet of the fat suction port 11 is connected with a large-caliber fat suction pipe (phi of the large-caliber fat suction pipe is more than or equal to 4mm, and caliber area S of a side hole is more than or equal to 10 mm) 2 ) The negative pressure water outlet13 are connected with a high negative pressure suction pipe (the high negative pressure is the negative pressure value of 0.02-0.07 Mpa), and a fat particle cutting device is arranged in the cylinder body 1.
The fat particle cutting device comprises a blade set arranged right below a fat suction port 11 in a cylinder body 1 and a first motor 21 for driving the blade set to rotate, wherein the first motor 21 is fixed on the cylinder body 1 through a first motor fixing frame 22, the first motor 21 is connected with a first rotating shaft 23 through a first transmission device 27, the blade set is arranged on the first rotating shaft 23, and the first rotating shaft 23 is in sealing connection with the cylinder body through a first sealing piece 26.
In this embodiment, a first funnel 111 is disposed below the fat suction port 11, and the outlet of the first funnel 111 is aligned with the blade set, so as to ensure that the fat coming from the fat suction port 11 enters the next step after passing through the cutting of the blade set.
As shown in fig. 2 to 5, the blade set has various arrangements,
first kind: the blade sets comprise a layer, each set comprising two blades 24 or four blades 24 symmetrically mounted on a blade holder 25, said blades 24 being at an angle a of 0 ° to the horizontal.
Second kind: the blade sets are arranged in an upper group and a lower group, each blade set comprises two blades 24 or four blades 24 symmetrically arranged on a tool rest 25, and the included angle a between the blades and the horizontal plane is 15 degrees.
By cutting large particles of fat into finer fat particles with double or even multi-layered blades, better fat reception is achieved.
In this example
Example 2:
this embodiment is further improved on the basis of embodiment 1, is equipped with the shower nozzle on the water inlet in barrel 1, the shower nozzle is towards the blade group, fat granule cutting device's export and collection dish 4 top opening intercommunication, the filter screen, upper portion opening are all around and the bottom surface of collection dish 4, the filter screen aperture of collection dish 4 is less than the fat granule after the cutting, the bottom of collection dish 4 is equipped with the valve and passes through hose line 7 and discharge and collect the mouth intercommunication, the negative pressure outlet 13 of barrel 1 sets up in the outside side of collection dish 4, is not higher than the upper portion opening of collection dish 4. By adopting the embodiment, the cleaning of fat particles can be realized while the large-particle fat is cut, the cleaned blood is pumped out from the outlet of the cavity through negative pressure, and the small-particle fat is remained in the collecting tray due to the filtering effect of the filter screen, and can be clamped with the injector through the fat discharging and collecting port, so that the small-particle fat is pumped out.
In this example, the bottom of the collecting tray 4 is in an inverted cone shape, so that the collection of fat particles is facilitated.
Example 3:
this embodiment is further improved on the basis of embodiment 2, is equipped with agitating unit in barrel 1 in the below of collecting tray 4, separates through protection network 5 between collecting tray 4 and the agitating unit, agitating unit includes stirring vane 34 and the rotatory second motor 31 of drive stirring vane that sets up in the cavity, second motor 31 passes through second transmission 32 and is connected with the second rotation axis, stirring vane 34 installs on the second rotation axis, second rotation axis passes through second sealing member 33 sealing connection with barrel 1, from the top down includes cutting area, collecting area and stirring area in proper order in the cavity, fat granule cutting device sets up in the cutting area, the collecting tray sets up in the collecting area, agitating unit sets up in the stirring area like this, and agitating unit stirs the broken fat granule of cutting for sewage further discharges, guarantees the cleaning performance of fat granule, moreover through the drain of the bottom of cavity can also wash the cavity.
When the device is used, the negative pressure suction system of the hospital is connected to the cavity inlet through the silica gel tube, so that high negative pressure is formed in the cavity and at the cavity outlet, and fat of a patient is sucked through the large-caliber fat suction tube.
In addition, it should be noted that, the present invention is not limited to the above embodiments, and as long as the parts thereof are not described in specific dimensions or shapes, the parts may be any dimensions or shapes suitable for the structures thereof, and any changes in the material composition thereof, and all the structural designs provided by the present invention are all modifications of the present invention, which should be considered to be within the scope of the present invention.
Claims (6)
1. An in vitro fine particle fat preparation all-in-one machine which is characterized in that: comprises a sterile sealed cavity, wherein the fine granular fat refers to granular fat with the particle diameter d less than 2mm, the cavity is provided with an inlet and an outlet, the inlet of the cavity is connected with a large-caliber fat suction pipe, the phi of the large-caliber fat suction pipe is more than or equal to 4mm, and the caliber area S of a side hole is more than or equal to 10mm 2 The device comprises a cavity, a high negative pressure device, a fat particle cutting device, a washing device, a fat discharge collection port and a fat discharge device, wherein an outlet of the cavity is connected with the high negative pressure device, the negative pressure value of the high negative pressure device is 0.02-0.07 mpa, the fat particle cutting device is arranged in the cavity and comprises a first funnel which is arranged in the cavity and used for receiving fat particles, a blade group which is arranged right below the outlet of the first funnel, and a first motor which drives the blade group to rotate, the cavity is also provided with the washing device for cleaning fat in the cavity through water and the fat discharge collection port used for discharging fat, and washing water in the cavity is discharged through the high negative pressure device at the outlet of the cavity;
the washing device comprises a water inlet and a collecting disc, an outlet of the fat particle cutting device is communicated with an opening above the collecting disc, the periphery and the bottom surface of the collecting disc are both provided with a filter screen and an opening at the upper part, the pore diameter of the filter screen of the collecting disc is smaller than that of the cut fat particles, a valve is arranged at the bottom of the collecting disc and communicated with a fat discharging collecting opening through a pipeline, an outlet of the cavity is arranged at the outer side of the collecting disc, and the bottom of the collecting disc is in an inverted cone shape;
the utility model discloses a fat particle stirring device, including the cavity, the cavity is equipped with agitating unit in the below of collecting tray, still includes the barrel, the barrel middle part forms the cavity, from the top down includes cutting area, collecting area and stirring area in proper order in the cavity, fat particle cutting device sets up in cutting area, the collecting tray sets up in collecting area, agitating unit sets up in stirring area.
2. The in vitro fine particulate fat preparation all-in-one machine of claim 1, wherein: the blade sets are axially distributed along the rotating shaft, each blade set comprises at least two blades symmetrically distributed along the rotating shaft, and the blades and the horizontal plane are provided with an included angle of 0-15 degrees.
3. The in vitro fine particulate fat preparation all-in-one machine according to claim 1 or 2, characterized in that: and a spray head is arranged on the water inlet in the cavity body, and faces the fat particle cutting device.
4. An in vitro fine particulate fat preparation all-in-one machine according to claim 3, wherein: the stirring device comprises a stirring blade arranged in the cavity and a second motor for driving the stirring blade to rotate.
5. An in vitro fine particulate fat preparation all-in-one machine according to claim 3, wherein: and a drain valve is arranged at the bottom of the cavity.
6. The in vitro fine particulate fat preparation all-in-one machine of claim 2, wherein: the blade is connected with a first motor output end arranged outside the cylinder body through a rotating shaft, the rotating shaft is sealed with the inner wall of the cavity body through a sealing component, and the stirring shaft of the stirring device is also sealed with the inner wall of the cavity body through the sealing component.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910125174.3A CN109700488B (en) | 2019-02-20 | 2019-02-20 | External fine particle fat preparation all-in-one |
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| CN201910125174.3A CN109700488B (en) | 2019-02-20 | 2019-02-20 | External fine particle fat preparation all-in-one |
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| CN109700488A CN109700488A (en) | 2019-05-03 |
| CN109700488B true CN109700488B (en) | 2023-09-26 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110523491B (en) | 2019-09-30 | 2024-08-06 | 长沙赋妍医疗科技有限公司 | Fat cutter |
| CN110560232B (en) * | 2019-09-30 | 2024-04-30 | 长沙赋妍医疗科技有限公司 | External fine particle fat preparation all-in-one |
| WO2021062967A1 (en) * | 2019-09-30 | 2021-04-08 | 中南大学湘雅医院 | Adipose cutter and all-in-one machine for in-vitro fine granular adipose preparation |
| CN110743447B (en) * | 2019-10-15 | 2021-10-08 | 北京润美玉之光医疗美容门诊部 | Method for improving autologous fat transplantation survival rate |
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| KR20090000768U (en) * | 2008-12-18 | 2009-01-28 | 배동환 | Hand piece for liposuction device |
| CN105438655A (en) * | 2015-12-31 | 2016-03-30 | 暨南大学 | Low-temperature granular fat collecting device for fat transplantation |
| CN108014384A (en) * | 2017-12-28 | 2018-05-11 | 山西阳光中天医疗器械有限公司 | A kind of closed full-automatic fat transfer equipment and its fat transfer method |
| CN207452106U (en) * | 2017-06-27 | 2018-06-05 | 谭铖洸 | For the fat-derived primary stem cell collection piece-rate system of binary channels of human body liposuction |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10967110B2 (en) * | 2011-07-08 | 2021-04-06 | Jointechlabs, Inc. | System and methods for preparation of adipose-derived stem cells |
| US10188777B2 (en) * | 2015-08-20 | 2019-01-29 | Aurastem Llc | Liposuction device and system and use thereof |
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- 2019-02-20 CN CN201910125174.3A patent/CN109700488B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090000768U (en) * | 2008-12-18 | 2009-01-28 | 배동환 | Hand piece for liposuction device |
| CN105438655A (en) * | 2015-12-31 | 2016-03-30 | 暨南大学 | Low-temperature granular fat collecting device for fat transplantation |
| CN207452106U (en) * | 2017-06-27 | 2018-06-05 | 谭铖洸 | For the fat-derived primary stem cell collection piece-rate system of binary channels of human body liposuction |
| CN108014384A (en) * | 2017-12-28 | 2018-05-11 | 山西阳光中天医疗器械有限公司 | A kind of closed full-automatic fat transfer equipment and its fat transfer method |
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