CN109700488A - A kind of external fine grained fat prepares all-in-one machine - Google Patents
A kind of external fine grained fat prepares all-in-one machine Download PDFInfo
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- CN109700488A CN109700488A CN201910125174.3A CN201910125174A CN109700488A CN 109700488 A CN109700488 A CN 109700488A CN 201910125174 A CN201910125174 A CN 201910125174A CN 109700488 A CN109700488 A CN 109700488A
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- 238000007443 liposuction Methods 0.000 claims abstract description 26
- 230000008676 import Effects 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims abstract description 4
- 238000005520 cutting process Methods 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 210000000577 adipose tissue Anatomy 0.000 claims description 9
- 239000010865 sewage Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 abstract description 8
- 229920001296 polysiloxane Polymers 0.000 abstract description 4
- 238000000746 purification Methods 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 9
- 210000001789 adipocyte Anatomy 0.000 description 6
- 239000004519 grease Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 4
- 230000017074 necrotic cell death Effects 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000036770 blood supply Effects 0.000 description 2
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000003195 fascia Anatomy 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000002711 centrocyte Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Crushing And Pulverization Processes (AREA)
Abstract
A kind of external fine grained fat prepares all-in-one machine, the cavity including a sterile sealing, and the cavity is equipped with inlet and outlet, the import of the cavity and heavy caliber liposuction pipe (caliber >=4mm, side opening area >=10mm2) connect, the outlet of the cavity is connect by silicone tube with high negative pressure device, and lipochondrion cutter device and wash mill are provided in the cavity.The problems such as suction lipectomy is time-consuming and laborious during the present invention solves fat transfer, and fat stem cell content is low, purification process is easy to pollute.
Description
Technical field
The present invention relates to a kind of external fine grained fat to prepare all-in-one machine.
Background technique
Autologous fat is because of abundance, and materials are convenient, and no rejection is easy to operate, and filling shape is good, and there is no diseases to pass
Dye, it is postoperative not leave the multiple advantages such as scar, it is widely used in clinic, is even more to become tissue filling in plastic surgery, the surface of a wound is repaired
Multiple conventional means.But its transplanting survival rate, the uncertainty of especially long-term surviving are still the main barrier for limiting its application so far
Hinder.Survival rate especially long-term surviving rate fatty after transplanting is improved, is still that current needs urgently solve the problems, such as.Numerous studies are aobvious
Show: transplant fat tissue volume still can only retain 50%-80 at present.
Researches show that: transplanting early stage, adipose tissue are in ischemic, anaerobic condition, provide nutrition, rouge by surrounding tissue liquid
Fat cell is away from by existence in area 1.5 ± 0.5mm of interstitial fluid, well, 5 days after operation new vessels are sprouted by graft periphery
Hair, but such as lipochondrion diameter is more than 2mm, is limited by tissue fluid disperse distance, and lipochondrion center fat cell is sought because obtaining
It supports and oxygen is limited and liquefaction, necrosis occurs.So the fat of transplanting is being obtained nutrition early stage by area, is establishing blood supply in time and exist
It is largely determined by lipochondrion diameter.
2001, Zuk etc. had found mescenchymal stem cell (mesenchymal stem in adipose tissue for the first time
Cells, MSCs), referred to as adipose-derived stem cells (adipose-derived stem cells, ADSCs).With derived from bone marrow
MSCs is the same, and ADSCs equally has good self-renewing and multi-lineage potential.But fat stem cell, which obtains, to be more convenient, and
Pain is smaller, it is often more important that stem cell content is 500~1000 times of marrow in adipose tissue.ADSCs is in fat transfer
On the one hand the vessel density in free grafting adipose tissue can be improved in journey, help graft early stage to establish in time and sufficient
Blood supply；On the other hand it can be divided into fat cell, reduced adipocyte number is supplemented, to effectively raise transplanting rouge
The survival rate of fat.Improve the content of ADSCs in transplant fat.
Large Diameter Pipeline (refers to φ >=4mm, side opening aperture area S >=10mm2Caliber) liposuction needle obtain lipochondrion
Greatly, and the disperse of tissue fluid apart from limited, fatty centrocyte transports bad necrosis because of blood.Therefore, clinical generally acknowledged small diameter tube (φ=
2mm, S=1mm2), lower negative pressure suction lipectomy be that fat transfer is successfully crucial, Large Diameter Pipeline liposuction pipe do not recommend for fat move
Plant liposuction.
Although small diameter tube liposuction pipe liposuction has many advantages, ADSCs content is lower in the Grainy fat tissue aspirated,
Analysis reason may be mainly distributed on ADSCs it is related around the interstitial blood vessel and fascia connective tissue of adipose tissue, due to blood
The relatively fine and close and larger toughness feature of the tissue of pipe and fascia connective tissue, causes in fat acquired in small-bore liposuction pipe
ADSCs content is substantially reduced compared with donor site ADSCs content.
Summary of the invention
The present invention solves the deficiencies in the prior art and provides that a kind of liposuction is high-efficient, fatty survival rate is high after transplanting
External fine grained fat prepares all-in-one machine, and fine grained fat here refers to the Grainy fat tissue of particle diameter d < 2mm.
To achieve the goals above, the present invention adopts the following technical scheme:
A kind of external fine grained fat prepares all-in-one machine, the cavity including a sterile sealing, and the cavity is equipped with import
And outlet, the import of the cavity are connect with heavy caliber liposuction pipe, the outlet of the cavity passes through silicone tube and high negative pressure device
It connects, is provided with lipochondrion cutter device and wash mill in the cavity.The present apparatus using hospital's vacuum suction system or
Conventional fatty negative suction system (negative pressure value of high negative pressure device here is in 0.02~0.07Mpa), by vacuum suction system
It unites and is connected with the silicone tube for the outlet for connecting the cavity, so that cavity is interior and cavity outlet forms high negative pressure, passed through
Heavy caliber liposuction pipe aspirates patient's fat, and the bulky grain fat after suction passes through the cutting and grinding of lipochondrion cutter device
For little particle fat, not only solve the problems, such as because lipochondrion it is excessive caused by fat cell necrosis, and and solve institute
The problem that ADSCs content is too low in adipose tissue is obtained, while also ensuring cell activity, experiment is it has also been found that use Large Diameter Pipeline liposuction
Pipe, is remarkably improved clinical liposuction efficiency.
Further, the lipochondrion cutter device includes that setting is accepting the hopper outlet of lipochondrion just in the cavity
The set of blades of lower section and the first motor for driving the set of blades rotation.
Further, the multiple groups that the set of blades is axially laid along rotary shaft, every group of set of blades includes along axisymmetry
At least two panels blade laid, the blade and horizontal plane are equipped with 0 °~15 ° of angle, that is, say that blade can be with horizontal plane
In parallel.
Further, it is additionally provided on the cavity to the wash mill of chamber body fat water flowing cleaning and for fat discharge
Fat discharge collection port, the intracorporal washing water of chamber is discharged by the high negative pressure device of cavity outlet.
Further, the wash mill includes water inlet and catch tray, the outlet of the lipochondrion cutter device with
The connection of catch tray upper opening, the surrounding of the catch tray and bottom surface are strainer, upper opening, the opening of sieve of the catch tray
Diameter is less than the lipochondrion after cutting, and the bottom of the catch tray is equipped with valve and is connected to by pipeline with fat discharge collection port,
The outside of catch tray is arranged in the outlet of the cavity.Spray head is equipped in the cavity on water inlet, the spray head is towards rouge
Fat particle cutter device.
Further, the bottom of the catch tray is back taper.
Further, agitating device is equipped in the lower section of catch tray in the cavity.
Further, the agitating device includes the of setting stirring blade in the cavity and driving stirring blade rotation
Two motors.
Further, the bottom of the cavity is equipped with sewage draining exit.
Further, including cylinder, the cylinder middle part form the cavity, successively include from top to bottom in the cavity
Cutting region, collecting zone and stirring region, the lipochondrion cutter device setting is in cutting region, the catch tray setting
In collecting zone, the blender is arranged in stirring region.
Further, the blade is connect by rotary shaft with the first motor output end being arranged outside cylinder, the rotation
Axis and cavity inner wall are sealed using seal assembly, and the agitating shaft of the agitating device also uses seal assembly close with cavity inner wall
Envelope.
Using above-mentioned apparatus, change that " small diameter tube, lower negative pressure liposuction pipe must be used when fat transfer liposuction " is intrinsic to face
Bed thinking, by carefully analyze and preliminary experiment verify, production invent external fine grained fat pulverizer on the basis of, solve
The obstacle that current fat transfer is faced starts a completely new, a whole set of fat transfer technology.Pass through comparative analysis osculum
Diameter liposuction pipe, in high negative pressure, aspirates equal volume Grainy fat tissue ADSCs content in lower negative pressure and heavy caliber liposuction pipe, digested,
After cultivating and counting, stem cell population contained by the latter is found as the former 1.7~3 times, therefore heavy caliber, high negative pressure suction tube are more
Be conducive to ADSCs acquisition, the present apparatus makes bulky grain rouge using the fatty cutting and grinding in vitro being aspirated heavy caliber liposuction pipe
Fat becomes little particle fat, not only solve the problems, such as because lipochondrion it is excessive caused by fat cell necrosis, and solve institute
The problem that ADSCs content is too low in adipose tissue is obtained, while also ensuring cell activity, experiment is it has also been found that use Large Diameter Pipeline liposuction
Pipe, is remarkably improved clinical liposuction efficiency (up to 3~5 times).
In conclusion suction lipectomy is time-consuming and laborious during the present invention solves fat transfer, fat stem cell content is low,
The problems such as purification process is easy to pollute.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention.
Fig. 2 is a kind of main view of embodiment of set of blades of the present invention.
Fig. 3 is the left view of Fig. 2.
Fig. 4 is the top view of Fig. 2.
Fig. 5 is the main view of the another embodiment of set of blades of the present invention.
Fig. 6 is the top view of Fig. 5.
In attached drawing, 1, cylinder, 11, grease absorbing port, 12, water inlet；13, drainage by suction mouth, 14, fat discharge collection port, 15,
Sewage draining exit, 21, first motor, 22, first motor fixed frame, the 23, first rotary shaft, 24, blade, 25, knife rest, 26, first is close
Sealing, the 27, first transmission device, the 31, second motor, the 32, second transmission device, 33, second seal, 34, stirring blade, 4,
Catch tray, 5, protective net, 6, stabilizer blade, 7, hose road.
Specific embodiment
For a better understanding of the present invention, with reference to the accompanying drawing and embodiment, invention is described in further detail, but
Embodiments of the present invention are not limited only to this, and protection scope of the present invention is also related to those skilled in the art and conceives according to the present invention
It is conceivable that equivalent technologies mean.
Embodiment 1:
As shown in Figure 1, core of the present embodiment as the present apparatus, including cylinder 1, the cylinder 1 are supported on by stabilizer blade 6
On ground, cavity is formed in the middle part of the cylinder 1, the cylinder 1 is equipped with grease absorbing port 11, water inlet 12, drainage by suction mouth 13, fat
Discharge collection port 14 and sewage draining exit 15, the import of the grease absorbing port 11 connect the (φ of heavy caliber liposuction pipe with heavy caliber liposuction pipe
>=4mm, side opening aperture area S >=10mm2), the drainage by suction mouth 13 connect that (high negative pressure here is with high negative pressure suction tube
Negative pressure value is in 0.02~0.07Mpa), lipochondrion cutter device is provided in the cylinder 1.
The lipochondrion cutter device includes being arranged in cylinder 1 described in the set of blades and drive of 11 underface of grease absorbing port
The first motor 21 of set of blades rotation, the first motor 21 are fixed on cylinder 1 by first motor fixed frame 22, and described the
One motor 21 is connect by the first transmission device 27 with the first rotary shaft 23, and the set of blades is mounted in the first rotary shaft 23,
First rotary shaft 23 is tightly connected by first seal 26 and cylinder.
In the present embodiment, the lower section of grease absorbing port 11 is equipped with first funnel 111, and the outlet of the first funnel 111 is directed at knife
Piece group guarantees to enter back into after the cutting that the fat that grease absorbing port 11 is come in passes through set of blades to next step.
As shown in Fig. 2 to 5, there are many set of blades is arranged form,
The first: set of blades include one layer, every group of set of blades include the two panels blade 24 being symmetrically mounted on knife rest 25 or
The angle a of four blades 24, the blade 24 and horizontal plane is 0 °.
Second: set of blades sets two groups up and down, and every group of set of blades includes the two panels blade 24 being symmetrically mounted on knife rest 25
Or four blades 24, the angle a of the blade and horizontal plane are 15 °.
It, can be more preferable by the way that bulky grain fat can be cut into thinner lipochondrion under the double-deck even multi-layer cutter blade
Undertaking fat.
In this example
Embodiment 2:
The present embodiment is further improved on the basis of embodiment 1, is equipped with spray head, the spray in cylinder 1 on water inlet
Head are connected to set of blades, the outlet of the lipochondrion cutter device with 4 upper opening of catch tray, and the four of the catch tray 4
Week and bottom surface are strainer, upper opening, and the aperture of filter screen of the catch tray 4 is less than the lipochondrion after cutting, the collection
The bottom of disk 4 is equipped with valve and is connected to by hose road 7 with fat discharge collection port, and the drainage by suction mouth 13 of the cylinder 1 is arranged
In the exterior lateral sides of catch tray 4, not higher than the upper opening of catch tray 4.It, can be in cutting bulky grain fat using the present embodiment
While realize the cleaning of lipochondrion, watery blood after cleaning from the outlet of cavity by negative pressure extraction, and little particle fat by
In the filtration of strainer, to stay in catch tray, collection port, which is discharged, by fat can be clamped syringe, by little particle rouge
Fat extraction.
In this example, the bottom of the catch tray 4 is back taper, facilitates the collection of lipochondrion.
Embodiment 3:
The present embodiment is further improved on the basis of embodiment 2, is equipped with stirring dress in the lower section of catch tray 4 in cylinder 1
It sets, is separated between catch tray 4 and agitating device by protective net 5, the agitating device includes the paddle of setting in the cavity
Second motor 31 of piece 34 and driving stirring blade rotation, second motor 31 pass through the second transmission device 32 and the second rotation
Axis connection, the stirring blade 34 are mounted on the second shaft axis, and the second shaft axis and cylinder 1 pass through second seal 33
It is tightly connected, from top to bottom successively includes cutting region, collecting zone and stirring region in the cavity, the lipochondrion is cut
Device setting is cut in cutting region, in collecting zone, the agitating device is arranged in stirring region, in this way for the catch tray setting
Agitating device stirs the lipochondrion of cutting and crushing, so that sewage is further discharged, guarantees the cleaning effect of lipochondrion, and
And the sewage draining exit of the bottom by the cavity, cavity can also be cleaned.
In use, vacuum suction system is connected to the cavity by silicone tube and is entered using hospital's vacuum suction system
Mouthful, so that cavity is interior and cavity outlet forms high negative pressure, patient's fat is aspirated by heavy caliber liposuction pipe.
In addition, it should be noted that, this patent is not limited to above embodiment, as long as its part does not specify specific size
Or shape, then the part can be any size or shape adaptable with its structure, no matter and making in its material composition
Any variation, it is all to be designed using structure provided by the present invention, all it is a kind of deformation of the invention, is considered as in the present invention
Within protection scope.
Claims (12)
1. a kind of external fine grained fat prepares all-in-one machine, it is characterised in that: the cavity including a sterile sealing, the cavity
Equipped with inlet and outlet, the import of the cavity is connect with heavy caliber liposuction pipe, and the outlet of the cavity and high negative pressure device connect
It connects, lipochondrion cutter device is provided in the cavity.
2. external fine grained fat according to claim 1 prepares all-in-one machine, it is characterised in that: the lipochondrion cutting
Device include setting accept in the cavity the first funnel of lipochondrion, the set of blades that is arranged in immediately below the first hopper outlet and
Drive the first motor of the set of blades rotation.
3. external fine grained fat according to claim 2 prepares all-in-one machine, it is characterised in that: the set of blades is along rotation
The multiple groups that axis is axially laid, every group of set of blades include at least two panels blade laid along axisymmetry, the blade and level
Face is equipped with 0 °~15 ° of angle.
4. preparing all-in-one machine to external fine grained fat described in one of 3 according to claim 1, it is characterised in that: the cavity
On be additionally provided with to chamber body fat water flowing cleaning wash mill and for fat discharge fat discharge collection port, the cavity
Interior washing water is discharged by the high negative pressure device of cavity outlet.
5. external fine grained fat according to claim 4 prepares all-in-one machine, it is characterised in that: the wash mill includes
The outlet of water inlet and catch tray, the lipochondrion cutter device is connected to catch tray upper opening, and the four of the catch tray
Week and bottom surface are strainer, upper opening, and the aperture of filter screen of the catch tray is less than the lipochondrion after cutting, the catch tray
Bottom be equipped with valve by pipeline with fat be discharged collection port be connected to, the outside of catch tray is arranged in the outlet of the cavity.
6. external fine grained fat according to claim 5 prepares all-in-one machine, it is characterised in that: intaking in the cavity
Mouth is equipped with spray head, and the spray head is towards lipochondrion cutter device.
7. external fine grained fat according to claim 5 prepares all-in-one machine, it is characterised in that: the bottom of the catch tray
For back taper.
8. external fine grained fat according to claim 5 prepares all-in-one machine, it is characterised in that: collected in the cavity
The lower section of disk is equipped with agitating device.
9. external fine grained fat according to claim 8 prepares all-in-one machine, it is characterised in that: the agitating device includes
Stirring blade in the cavity and the second motor of driving stirring blade rotation are set.
10. external fine grained fat according to claim 5 prepares all-in-one machine, it is characterised in that: the bottom of the cavity
Equipped with sewage draining valve.
11. external fine grained fat according to claim 8 prepares all-in-one machine, it is characterised in that: it further include cylinder, it is described
The cavity is formed in the middle part of cylinder, from top to bottom successively includes cutting region, collecting zone and stirring region, institute in the cavity
The setting of lipochondrion cutter device is stated in cutting region, the catch tray setting exists in collecting zone, the agitating device setting
Stirring region.
12. external fine grained fat according to claim 11 prepares all-in-one machine, it is characterised in that: the blade passes through rotation
Shaft is connect with the first motor output end outside setting cylinder, and the rotary shaft and cavity inner wall are sealed using seal assembly, institute
The agitating shaft for stating agitating device also uses seal assembly to seal with cavity inner wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910125174.3A CN109700488B (en) | 2019-02-20 | 2019-02-20 | External fine particle fat preparation all-in-one |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910125174.3A CN109700488B (en) | 2019-02-20 | 2019-02-20 | External fine particle fat preparation all-in-one |
Publications (2)
| Publication Number | Publication Date |
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| CN109700488A true CN109700488A (en) | 2019-05-03 |
| CN109700488B CN109700488B (en) | 2023-09-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910125174.3A Active CN109700488B (en) | 2019-02-20 | 2019-02-20 | External fine particle fat preparation all-in-one |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110523491A (en) * | 2019-09-30 | 2019-12-03 | 中南大学湘雅医院 | A kind of Fat cutter |
| CN110560232A (en) * | 2019-09-30 | 2019-12-13 | 中南大学湘雅医院 | External fine particle fat preparation all-in-one |
| CN110743447A (en) * | 2019-10-15 | 2020-02-04 | 北京润美玉之光医疗美容门诊部 | Method for improving autologous fat transplantation survival rate |
| WO2021062967A1 (en) * | 2019-09-30 | 2021-04-08 | 中南大学湘雅医院 | Adipose cutter and all-in-one machine for in-vitro fine granular adipose preparation |
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| CN110523491A (en) * | 2019-09-30 | 2019-12-03 | 中南大学湘雅医院 | A kind of Fat cutter |
| CN110560232A (en) * | 2019-09-30 | 2019-12-13 | 中南大学湘雅医院 | External fine particle fat preparation all-in-one |
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| CN110743447A (en) * | 2019-10-15 | 2020-02-04 | 北京润美玉之光医疗美容门诊部 | Method for improving autologous fat transplantation survival rate |
| CN110743447B (en) * | 2019-10-15 | 2021-10-08 | 北京润美玉之光医疗美容门诊部 | Method for improving autologous fat transplantation survival rate |
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| Publication number | Publication date |
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| CN109700488B (en) | 2023-09-26 |
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