CN109692214A - It is a kind of for treating the pharmaceutical composition of hypertension - Google Patents
It is a kind of for treating the pharmaceutical composition of hypertension Download PDFInfo
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- CN109692214A CN109692214A CN201710992806.7A CN201710992806A CN109692214A CN 109692214 A CN109692214 A CN 109692214A CN 201710992806 A CN201710992806 A CN 201710992806A CN 109692214 A CN109692214 A CN 109692214A
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- hypertension
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- pharmaceutical composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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Abstract
The present invention provides a kind of for treating the pharmaceutical composition of hypertension.The present invention is made of drugs such as Cortex Eucommiae (stir-fry), motherwort, Prunella vulgaris, radix scutellariae, uncarias, through crushing, extraction, concentration, drying, capsule or tablet is made.Product obtained by the present invention has kidney tonifying, calming the liver, heat-clearing.Effect is used for the vascular hypertension of kidney deficiency liver-yang hyperactivity.Drug safety performance is high, and quality is stable, reliable, low in cost, easy to carry and storage, meets enterprise scale production requirement at this stage, the great prospect of marketing, effective percentage up to 98%, cure rate is up to 90%, and uneasy to recur.
Description
Technical field
The invention belongs to technical field of medicine, are related to a kind of pharmaceutical composition for treating hypertension.
Background technique
Hypertension (hypertension) refers to that it is main for increasing with systemic arterial blood pressure (systolic pressure and/or diastolic pressure)
Feature (systolic pressure >=140 millimetress of mercury, diastolic pressure >=90 millimetress of mercury), can be with the function or device matter of the organs such as the heart, brain, kidney
Property damage clinical syndrome.Hypertension is the most common chronic disease and the most important risk factor of cardiovascular and cerebrovascular diseases.
Currently, for the high blood pressure method thoroughly eradicated not yet, only by drug and patient it is good self
Health care, Morbidity control is preferable horizontal at one.The drug for being currently usually used in decompression mainly has following 5 class: calcium antagonist, blood
Guanine converting enzyme inhibitor (ACEI), hypertensinⅡreceptorretarder (ARB), thiazide diuretic, beta receptor retardance
Agent.Common compound preparation has compound reserpine (Compound Reserpine), compound hypoensive piece (decompression 0), precious chrysanthemum
Hypertension pill etc..
There is palliative, side effect big the drawbacks of needing Long-term taking medicine using western medicine method.Use immobilised compound
When preparation, the contraindication of its constituent of to master and possible adverse reaction.Therefore exploitation treating both manifestation and root cause of disease, curative effect are steady, malicious
The Chinese materia medica preparation of Small side effects is of great significance to guarantee human health, promotion Chinese medicine development.
Summary of the invention
The present invention is intended to provide a kind of, quality stable, significant in efficacy, easy to carry use with storage high with security performance
In the composition for the treatment of hypertension.
Composition provided by the present invention for treating hypertension is prepared by the medicinal material of following weight ratio:
28 ~ 30 parts of Cortex Eucommiae (stir-fry), 28 ~ 30 parts of motherwort, 16 ~ 18 parts of Prunella vulgaris, 16 ~ 18 parts of radix scutellariae, 7 ~ 9 parts of uncaria.
A kind of above-described preparation method of composition for treating hypertension includes the following steps:
1) in the above five kinds of Chinese medicine, it is spare that uncaria takes half amount to be ground into fine powder；
2) it in the above five kinds of Chinese medicine, takes half amount uncaria of prescription and other four traditional Chinese medicine materials that 8 times of amount water is added to decoct three times, 1 hour every time, closes
And decocting liquid, filtration, stand 24 hours, Aspirate supernatant, be concentrated into relative density be 1.35~1.38(80 DEG C) liquid extract；
3) above-mentioned uncaria fine powder is uniformly mixed with liquid extract, 60 DEG C are dried, crushed into fine powder；
4) 3) gained fine powder appropriate alcoholic solution is pelletized, 60 DEG C of dry 1.5h, 20 mesh sieves；
5) by 4) the gained additional lubricant total mix of dry particl, capsule or tablet is made in intermediates content measurement as needed.
Product obtained by the present invention has kidney tonifying, calming the liver, heat-clearing.Effect is used for the vascular hypertension of kidney deficiency liver-yang hyperactivity.Drug
Security performance is high, and quality is stable, reliable, low in cost, easy to carry and storage, and meeting the production of enterprise scale at this stage needs
It asks, the great prospect of marketing.Effective percentage up to 98%, cure rate is up to 90%, and uneasy to recur.
Medicinal material meridian distribution of property and flavor, function used by pharmaceutical composition of the present invention and cure mainly respectively it is as follows:
Cortex Eucommiae: sweet in flavor, micro-pungent；It is warm-natured.Enter liver and kidney channel.Nourishing liver and kidney , Qiang Zhu bone, miscarriage prevention.For kidney deficiency and liver, soreness of waist and knee joint , Zhu
Bone is powerless, has a dizzy spell, blood leaking in gestation, threatened abortion.
Motherwort: it is bitter, pungent, it is slightly cold.Return liver, pericardium, bladder meridian.Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema are clearing heat and detoxicating.For
Irregular menstruation, dysmenorrhea menostasis, lochiorrhagia, edema and little urine, sore swollen toxin.
Prunella vulgaris: it is pungent, bitter, it trembles with fear.Return liver, gallbladder channel.Clearing liver-fire, improving eyesight, mass dissipating and swelling eliminating.For red eye, swell pain, mesh pearl night
Bitterly, headache and dizziness, scrofula, goiter, acute mastitis, breast illness, swollen breasts.
Radix scutellariae: it is bitter, it trembles with fear.Return lung, gallbladder, spleen, large intestine, small intestinl channel.Heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention.For wet
Temperature, summer-heat and damp, chest tightness and emesis, damp and hot feeling of fullness, dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, movement of the foetus
It is uneasy.
Uncaria: it is sweet, it is cool.Return liver, pericardium channel.Dispelling wind and relieving convulsion, The flat liver of heat-clearing.For liver wind agitation, twitch, high fever is frightened
It faints, dysphoric cold, children's crying with fear, pre-eclampsia, headache and dizziness.
Specific embodiment
The present invention can be described in more detail in following implementation, but the invention is not limited in any way.
Embodiment 1
Prescription: 29 parts of Cortex Eucommiae (stir-fry), 29 parts of motherwort, 17 parts of Prunella vulgaris, 17 parts of radix scutellariae, 8 parts of uncaria
Preparation method:
1) in the above five kinds of Chinese medicine, it is spare that uncaria takes half amount to be ground into fine powder；
2) it in the above five kinds of Chinese medicine, takes half amount uncaria of prescription and other four traditional Chinese medicine materials that 8 times of amount water is added to decoct three times, 1 hour every time, closes
And decocting liquid, filtration, stand 24 hours, Aspirate supernatant, be concentrated into relative density be 1.35~1.38(80 DEG C) liquid extract；
3) above-mentioned uncaria fine powder is added, mixes, 60 DEG C are dried, crushed into fine powder；
4) by weight be added 95% ethanol solution granulation, 60 DEG C drying 2 hours, 20 mesh sieves；
5) additional 1% superfine silica gel powder, it is filling in No. 1 capsule, every 0.3g to get.
Embodiment 2
Prescription: 29 parts of Cortex Eucommiae (stir-fry), 29 parts of motherwort, 17 parts of Prunella vulgaris, 17 parts of radix scutellariae, 8 parts of uncaria
Preparation method:
1) in the above five kinds of Chinese medicine, it is spare that uncaria takes half amount to be ground into fine powder；
2) it in the above five kinds of Chinese medicine, takes half amount uncaria of prescription and other four traditional Chinese medicine materials that 8 times of amount water is added to decoct three times, 1 hour every time, closes
And decocting liquid, filtration, stand 24 hours, Aspirate supernatant, be concentrated into relative density be 1.35~1.38(80 DEG C) liquid extract；
3) fine powders such as above-mentioned uncaria are added, mix, 60 DEG C are dried, crushed into fine powder；
4) by weight be added 80% ethanol solution granulation, 60 DEG C drying 2 hours, 20 mesh sieves；
5) additional 1% magnesium stearate, 8mm scrobicula circular die tabletting, every 0.3g；
6) it is coated after taking pharmaceutical films coating premixing auxiliary material (gastric solubility) plus appropriate 80% ethyl alcohol to mix, film coating weight gain 3% ~
5% to get.
Embodiment 3:
Prescription: 28 parts of Cortex Eucommiae (stir-fry), 28 parts of motherwort, 16 parts of Prunella vulgaris, 16 parts of radix scutellariae, 7 parts of uncaria
The preparation method is the same as that of Example 1.
Embodiment 4:
Prescription: 28 parts of Cortex Eucommiae (stir-fry), 28 parts of motherwort, 16 parts of Prunella vulgaris, 16 parts of radix scutellariae, 7 parts of uncaria
Preparation method is the same as embodiment 2.
Embodiment 5:
Prescription: 30 parts of Cortex Eucommiae (stir-fry), 30 parts of motherwort, 18 parts of Prunella vulgaris, 18 parts of radix scutellariae, 9 parts of uncaria
The preparation method is the same as that of Example 1.
Embodiment 6:
Prescription: 30 parts of Cortex Eucommiae (stir-fry), 30 parts of motherwort, 18 parts of Prunella vulgaris, 18 parts of radix scutellariae, 9 parts of uncaria
Preparation method is the same as embodiment 2.
Clinical data:
Case 1: text certain, female, 61 years old, usually there are the symptoms such as headache and dizzy, dizziness, tinnitus, palpitaition, insomnia in retired employees, doctor
Institute is diagnosed as with moderate hypertension, blood pressure are as follows: systolic pressure 168, diastolic pressure 110.Doctor opens western medicine of depressurization, but the used time then drops,
Drug withdrawal then rises, and brings a series of adverse reactions such as increased heart rates, nodal tachycardia, headache, low blood pressure, lassitude.
Take Chinese medicine composition of the invention, one time 5,3 times a day, symptom is effectively relieved after two weeks, each after treatment 30 days
Kind symptom disappears, and blood pressure maintains normal value: systolic pressure 120, diastolic pressure 77, a year and a half is without recurrence.
Case 2: Liu, male, 44 years old, private enterprise senior executive, it was big to treat more operating pressures with courtesy, produced head at 40 years old
Dizzy, palpitaition, insomnia, mind is not peaceful, the symptoms such as absent minded, after be diagnosed as hypertension, blood pressure is systolic pressure 165, is relaxed
Open pressure 100.Take Chinese medicine composition of the invention, one time 5,3 times a day, symptom is effectively relieved after 10 days, treatment 30
Various symptoms disappear after it, and blood pressure maintains normal value: systolic pressure 118, diastolic pressure 76.Follow-up 2 years without recurrence.
Case 3: Lee, male, 42 years old, worker, discovery suffered from hypertension when physical examination, and blood pressure is systolic pressure 170, diastolic pressure
108, doctor suggests that movement is outer and takes drugs conditioning, takes Chinese medicine composition of the invention, one time 5,3 times a day, continuous clothes
After 30 days, blood pressure is restored to normal value: systolic pressure 115, diastolic pressure 72, follow-up half a year is without recurrence.
Claims (4)
1. a kind of for treating the pharmaceutical composition of hypertension, which is characterized in that be prepared by the medicinal material of following weight ratio:
28 ~ 30 parts of Cortex Eucommiae (stir-fry), 28 ~ 30 parts of motherwort, 16 ~ 18 parts of Prunella vulgaris, 16 ~ 18 parts of radix scutellariae, 7 ~ 9 parts of uncaria.
2. according to claim 1 a kind of for treating the pharmaceutical composition of hypertension it is characterized in that, prepared by composition
Method includes the following steps:
1) in the above five kinds of Chinese medicine, it is spare that uncaria takes half amount to be ground into fine powder；
2) it in the above five kinds of Chinese medicine, takes half amount uncaria of prescription and other four traditional Chinese medicine materials that 8 times of amount water is added to decoct three times, 1 hour every time, closes
And decocting liquid, filtration, stand 24 hours, Aspirate supernatant, be concentrated into relative density be 1.35~1.38(80 DEG C) liquid extract；
3) above-mentioned uncaria fine powder is uniformly mixed with liquid extract, 60 DEG C are dried, crushed into fine powder；
4) 3) gained fine powder appropriate alcoholic solution is pelletized, 60 DEG C of dry 1.5h, 20 mesh sieves；
5) by 4) the gained additional lubricant total mix of dry particl, capsule or tablet is made in intermediates content measurement as needed.
3. according to claim 2 a kind of for treating the pharmaceutical composition of hypertension, which is characterized in that the alcoholic solution
Concentration is 80-95%.
4. according to claim 2 a kind of for treating the pharmaceutical composition of hypertension, which is characterized in that the lubricant
For superfine silica gel powder or magnesium stearate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710992806.7A CN109692214A (en) | 2017-10-23 | 2017-10-23 | It is a kind of for treating the pharmaceutical composition of hypertension |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710992806.7A CN109692214A (en) | 2017-10-23 | 2017-10-23 | It is a kind of for treating the pharmaceutical composition of hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109692214A true CN109692214A (en) | 2019-04-30 |
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ID=66225815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710992806.7A Pending CN109692214A (en) | 2017-10-23 | 2017-10-23 | It is a kind of for treating the pharmaceutical composition of hypertension |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109692214A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494556A (en) * | 2020-11-25 | 2021-03-16 | 王红卫 | Oral medicine for treating hypertension |
| CN115192644A (en) * | 2022-05-23 | 2022-10-18 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | Application of eucommia ulmoides compound preparation in preparation of medicines for treating non-alcoholic fatty liver disease |
-
2017
- 2017-10-23 CN CN201710992806.7A patent/CN109692214A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494556A (en) * | 2020-11-25 | 2021-03-16 | 王红卫 | Oral medicine for treating hypertension |
| CN115192644A (en) * | 2022-05-23 | 2022-10-18 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | Application of eucommia ulmoides compound preparation in preparation of medicines for treating non-alcoholic fatty liver disease |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190430 |
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| WD01 | Invention patent application deemed withdrawn after publication |