CN109674867A - 一种用于过敏性牙周炎和牙龈炎的药物及其制备方法 - Google Patents
一种用于过敏性牙周炎和牙龈炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于过敏性牙周炎和牙龈炎的药物及其制备方法，药用有效成分由木犀、松花粉壳、火炭母、绞股蓝、淫羊藿及臭山羊制成。本发明的药物具有抗敏、活血镇痛、潜阳顾本、清热解毒、促进消炎、生肌和固齿功效，达到了纠正细胞呼吸与物质代谢，改善牙龈微循环障碍的作用，用于过敏性牙周炎和牙龈炎治疗实用性强，在治疗时无需使用抗生素。
Description
技术领域
本发明涉及一种用于过敏性牙周炎和牙龈炎的药物及其制备方法，属于药品技术的领域。
背景技术
牙周病是指发生在牙支持组织(牙周组织)的疾病，包括仅累及牙龈组织的牙龈病和波及深层牙周组织(牙周膜、牙槽骨、牙骨质)的牙周炎两大类。牙周疾病是常见的口腔疾病，是引起成年人牙齿丧失的主要原因之一，也是危害人类牙齿和全身健康的主要口腔疾病。
牙周病的早期症状不易引起重视，造成牙周组织长期慢性感染，炎症反复发作，不仅损害口腔咀嚼系统的功能，还会严重影响健康。
牙周炎在牙周病中最常见，主要表现有牙龈红肿出血，牙周袋形成、牙周袋溢脓、牙齿松动、牙龈退缩、牙周脓肿等，牙周炎以形成病理性牙周袋为主要病变。
牙龈炎主要是局限于牙龈组织的炎症性病变，一般不累及深部牙周组织。
多年来，人类为与自然界疾病作斗争同时研制和发明了各种针对疾病的有效药物，而我国民间更有很多显效优秀而可靠的药物；亦是我国的瑰宝，而目前用于过敏性牙周炎和牙龈炎的药物疗效及效速尚不理想，药物还有一定毒副作用。
因此，发明这种有具有抗敏、活血镇痛、潜阳顾本、清热解毒、促进消炎、生肌和固齿功效，用于过敏性牙周炎和牙龈炎的药物具有重要的意义。
发明内容
本发明的目的在于，提供一种用于过敏性牙周炎和牙龈炎的药物。本发明的药物具有抗敏、活血镇痛、潜阳顾本、清热解毒、促进消炎、生肌和固齿功效，达到了纠正细胞呼吸与物质代谢，改善牙龈微循环障碍的作用，用于过敏性牙周炎和牙龈炎治疗实用性强，在治疗时无需使用抗生素。
本发明的技术方案：一种用于过敏性牙周炎和牙龈炎的药物，药用有效成分照重量组份计算，由木犀5-25份、松花粉壳5-25份、火炭母10-30份、绞股蓝5-25份、淫羊藿5-25份、臭山羊5-25份制成。
前述的用于过敏性牙周炎和牙龈炎的药物中，所述药用有效成分照重量组份计算，由木犀15份、松花粉壳15份、火炭母20份、绞股蓝15份、淫羊藿15份、臭山羊15份制成。
前述用于过敏性牙周炎和牙龈炎的药物的制备方法，取上述药物，与药物中可接受的辅料进行组合，或不加辅料，按照常规方法进行加工，制成相应的药物制剂。
前述用于过敏性牙周炎和牙龈炎的药物的制备方法中，所述药物制剂为口服制剂。
前述用于过敏性牙周炎和牙龈炎的药物的制备方法中，所述口服制剂为汤剂、颗粒剂或煎膏剂。
前述用于过敏性牙周炎和牙龈炎的药物的制备方法中，所述汤剂这样制备：按比例称取上述药物，加入1-3倍量的水，砂锅文火煎煮15-20min，趁热滤过药渣保留煎液A，向药渣中加入1-2倍量的水，文火煎煮15-20min，趁热滤过药渣保留煎液B，合并煎液A和煎液B，即得该汤剂。
前述用于过敏性牙周炎和牙龈炎的药物的制备方法中，所述颗粒剂这样制备：按比例称取上述药物，粉碎成最粗粉，加水浸泡20-30min，文火煎煮三次，每次20min，合并煎液，滤过，滤液浓缩至80℃时相对密度为1.30～1.35的稠膏，加入制成量38％的糊精、制成量50％的蔗糖，混匀，制成颗粒，干燥，即得该颗粒剂。
前述用于过敏性牙周炎和牙龈炎的药物的制备方法中，所述煎膏剂这样制备：按比例称取上述药物，粉碎成最粗粉，加水浸泡20-30min，煎煮3次，第一次用4倍量的水煎煮30min，第二次用3倍量的水煎煮20min，第三次用2倍量的水煎煮10min，合并煎液，滤过，浓缩成60-65℃时相对密度为的1.10-1.15的浸膏，然后于浸膏中加入浸膏量50％的蜂蜜,加热混匀，浓缩至60-65℃时相对密度为1.2-1.25的浸膏，即得该煎膏剂。
本发明药用有效成分由木犀、松花粉壳、火炭母、绞股蓝、淫羊藿及臭山羊制成，其中木犀，又名桂花，为木犀科植物木犀Osmanthus fragrans(Thunb.)Lour.的花；具有温肺化饮，散寒止痛之功效；用于痰饮咳喘，脘腹冷痛，肠风血痢，经闭痛经，寒疝腹痛，牙痛，口臭。松花粉壳，为松科植物马尾松Pinus massoniana Lamb.、油松Pinus tabulaeformisCarr.或同属数种植物的干燥花粉；功能主治燥湿，收敛止血；用于湿疹，黄水疮，皮肤糜烂，脓水淋漓，外伤出血；尿布性皮炎。火炭母，为蓼科植物火炭母草的干燥地上部分；有清热解毒，利湿消滞，凉血止痒，明止退翳功效；用于痢疾，消化不良，肝炎，感冒，扁桃体炎，咽喉炎，白喉，百日咳，角膜云翳，乳腺炎，霉菌性阴道炎，白带，疖肿，小儿脓疱，湿疹，毒蛇咬伤。绞股蓝，为葫芦科植物绞股蓝的全草；功能主治为：消炎解毒，止咳祛痰；用作滋补强壮药。淫羊藿，为小檗科植物淫羊藿Epimedium brevicornum Maxim.、箭叶淫羊藿Epimediumsagittatum(Sieb.et Zucc.)Maxim.、柔毛淫羊藿Epimedium pubescens Maxim.、巫山淫羊藿Epimedium wushanense T.S.Ying或朝鲜淫羊藿Epimedium koreanum Nakai的干燥地上部分；有补肾阳，强筋骨，祛风湿功效；用于阳痿遗精，筋骨痿软，风湿痹痛，麻木拘挛；更年期高血压。臭山羊，为芸香科植物日本常山的根；功能主治为：清热解表，行气止痛，祛风利湿。治风热感冒，咳嗽，喉痛，牙痛，胃痛，风湿关节痛，痢疾，无名肿毒。
本方所治疾病为过敏性牙周炎、牙龈炎、牙龈退缩，方中木犀、松花粉壳、火炭母、绞股蓝抗敏、活血镇痛，淫羊藿潜阳顾本，臭山羊清热解毒，诸药配伍，共凑纠正细胞呼吸与物质代谢、改善牙龈微循环障碍,促进消炎、生肌，固齿的效果。
与现有技术相比，本发明具有以下特点：
1.疗效好、起效快，治疗效果稳定：
2.安全，无任何毒副作用；
3.无需使用抗生素，避免患者对抗生素的依赖，同时避免因使用抗生素所产生的毒副作用；
4.能有效针对感染或因创伤引发的发炎疼痛，还能解决牙龈萎缩坏死导致的牙齿松动问题，治疗无需打针、输液，更无需拔牙，解决了患者诸多方面痛苦之忧虑。
发明人为验证本发明的效果进行了大量的实验研究，以下为本发明实验研究的结果：
实验例1：药效研究
治疗实例
患者1：陆国云，男，30岁，现居住贵州省独山县森林公园；
患者症状：牙龈组织肿胀，牙龈发痒不适，牙龈出血，
患者排服用本发明实施例1所制成的药物1天后症状好转，3天后恢复正常，无不良反应。
经患者自述：
用药第一天，牙龈发痒感减轻，牙龈组织肿胀初步消退；
用药第二天，牙龈发痒感消除，牙龈组织肿胀消退；
用药第三天；牙龈完全恢复正常，无肿胀和发痒不适感。
患者2：莫启群，女，现61，独山县城西村梁家院小组村民；
患者症状：牙龈红肿，有牙痛，对冷和酸的食物有刺激和敏感的表现。
牙龈组织肿胀，牙龈发痒不适，牙龈出血，
患者排服用本发明实施例1所制成的药物3天后症状好转，6天后恢复正常，无不良反应。
经患者自述：
用药第二天，牙龈红肿初步消退；
用药第三天，牙龈红肿消除，牙痛明显减轻；
用药第四天，对冷和酸食物的刺激和敏感程度大幅降低；
用药第六天；牙龈完全恢复正常，牙痛消失，对冷和酸食物已无刺激和敏感表现。
患者3：孟庆远，男，30岁，独山县城西村梁家院小组村民；
患者症状：因骑摩托车跌伤，损伤牙齿，患处牙龈发蓝坏死，牙齿有松动现象。
患者排服用本发明实施例1所制成的药物3天后症状好转，一周后恢复正常，无不良反应。
经患者自述：
用药第二天，患处牙龈逐渐愈合，牙痛减轻；
用药第三天，患处牙龈创口明显缩小；
用药第五天，患处牙龈组织被复，牙齿有松动现象减轻；
用药第七天；牙龈坏死部分完全恢复正常，牙痛消失。
患者4：曹敏，女，独山县人民医院神经内科临床主治医师；
患者症状：牙龈炎，并有脓肿疼痛难忍，导致牙齿松动。
患者排服用本发明实施例1所制成的药物3天后恢复正常，无不良反应。
经患者自述：
用药第一天，牙龈脓肿初步消退，疼痛减轻；
用药第二天，牙龈脓肿消除，疼痛明显减轻；
用药第三天，牙龈完全恢复正常，疼痛消失，无牙齿松动表现。
上述患者在治疗时均未使用抗生素药物，避免了抗生素的危害。
综上所述，本发明的药物具有抗敏、活血镇痛、潜阳顾本、清热解毒、促进消炎、生肌和固齿功效，达到了纠正细胞呼吸与物质代谢，改善牙龈微循环障碍的作用，用于过敏性牙周炎和牙龈炎治疗实用性强，在治疗时未使用抗生素，也无需打针和输液，更无需拔牙，解决了患者诸多方面痛苦之忧虑。
具体实施方式
下面结合实施例对本发明作进一步的说明，但并不作为对本发明限制的依据。
实施例1：一种用于过敏性牙周炎和牙龈炎的药物，药用有效成分由木犀15g、松花粉壳15g、火炭母20g、绞股蓝15g、淫羊藿15g、臭山羊15g制成。
所述药物为汤剂，该汤剂这样制备：按比例称取上述药物，加入1.5倍量的水，砂锅文火煎煮17min，趁热滤过药渣保留煎液A，向药渣中加入1倍量的水，文火煎煮17min，趁热滤过药渣保留煎液B，合并煎液A和煎液B，即得该汤剂。
用法用量：口服，100ml/次，3次/日，饭后半小时温服。
实施例2：一种用于过敏性牙周炎和牙龈炎的药物，药用有效成分由木犀50g、松花粉壳50g、火炭母100g、绞股蓝50g、淫羊藿50g、臭山羊50g制成。
所述药物为颗粒剂，该颗粒剂这样制备：按比例称取上述药物，粉碎成最粗粉，加水浸泡25min，文火煎煮三次，每次20min，合并煎液，滤过，滤液浓缩至80℃时相对密度为1.33的稠膏，加入制成量38％的糊精、制成量50％的蔗糖，混匀，制成颗粒，干燥，分装成5g/袋，即得该颗粒剂。
用法用量：饭前半小时温水冲服，每日2-3次，每次2-3袋。
实施例3：一种用于过敏性牙周炎和牙龈炎的药物，药用有效成分由木犀25g、松花粉壳25g、火炭母30g、绞股蓝25g、淫羊藿25g、臭山羊25g制成。
所述药物为煎膏剂，该煎膏剂这样制备：按比例称取上述药物，粉碎成最粗粉，加水浸泡25min，煎煮3次，第一次用4倍量的水煎煮30min，第二次用3倍量的水煎煮20min，第三次用2倍量的水煎煮10min，合并煎液，滤过，浓缩成65℃时相对密度为的1.14的浸膏，然后于浸膏中加入浸膏量50％的蜂蜜,加热混匀，浓缩至65℃时相对密度为1.24的浸膏，即得该煎膏剂。
用法用量：饭前半小时温水冲服，每日2-3次，每次10-30g。
Claims (8)
1.一种用于过敏性牙周炎和牙龈炎的药物，其特征在于：药用有效成分照重量组份计算，由木犀5-25份、松花粉壳5-25份、火炭母10-30份、绞股蓝5-25份、淫羊藿5-25份、臭山羊5-25份制成。
2.根据权利要求1所述的用于过敏性牙周炎和牙龈炎的药物，其特征在于：所述药用有效成分照重量组份计算，由木犀15份、松花粉壳15份、火炭母20份、绞股蓝15份、淫羊藿15份、臭山羊15份制成。
3.一种如权利要求1或2所述用于过敏性牙周炎和牙龈炎的药物的制备方法，其特征在于：取上述药物，与药物中可接受的辅料进行组合，或不加辅料，按照常规方法进行加工，制成相应的药物制剂。
4.根据权利要求3所述用于过敏性牙周炎和牙龈炎的药物的制备方法，其特征在于：所述药物制剂为口服制剂。
5.根据权利要求4所述用于过敏性牙周炎和牙龈炎的药物的制备方法，其特征在于：所述口服制剂为汤剂、颗粒剂或煎膏剂。
6.根据权利要求5所述用于过敏性牙周炎和牙龈炎的药物的制备方法，其特征在于：所述汤剂这样制备：按比例称取上述药物，加入1-3倍量的水，砂锅文火煎煮15-20min，趁热滤过药渣保留煎液A，向药渣中加入1-2倍量的水，文火煎煮15-20min，趁热滤过药渣保留煎液B，合并煎液A和煎液B，即得该汤剂。
7.根据权利要求5所述用于过敏性牙周炎和牙龈炎的药物的制备方法，其特征在于：所述颗粒剂这样制备：按比例称取上述药物，粉碎成最粗粉，加水浸泡20-30min，文火煎煮三次，每次20min，合并煎液，滤过，滤液浓缩至80℃时相对密度为1.30～1.35的稠膏，加入制成量38％的糊精、制成量50％的蔗糖，混匀，制成颗粒，干燥，即得该颗粒剂。
8.根据权利要求5所述用于过敏性牙周炎和牙龈炎的药物的制备方法，其特征在于：所述煎膏剂这样制备：按比例称取上述药物，粉碎成最粗粉，加水浸泡20-30min，煎煮3次，第一次用4倍量的水煎煮30min，第二次用3倍量的水煎煮20min，第三次用2倍量的水煎煮10min，合并煎液，滤过，浓缩成60-65℃时相对密度为的1.10-1.15的浸膏，然后于浸膏中加入浸膏量50％的蜂蜜,加热混匀，浓缩至60-65℃时相对密度为1.2-1.25的浸膏，即得该煎膏剂。
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