CN109674865A - A kind of burn and scald medicament and preparation method thereof - Google Patents
A kind of burn and scald medicament and preparation method thereof Download PDFInfo
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- CN109674865A CN109674865A CN201910154001.4A CN201910154001A CN109674865A CN 109674865 A CN109674865 A CN 109674865A CN 201910154001 A CN201910154001 A CN 201910154001A CN 109674865 A CN109674865 A CN 109674865A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The invention belongs to clinical medicine technical fields, a kind of burn and scald medicament and preparation method thereof is disclosed, the burn and scald medicament is made of 15-30 parts of rheum officinale, 15-30 parts of gypsum rubrum, 10-20 parts of gypsum, 20-30 parts of the coptis and 10-20 parts of charred RADIX SANGUISORBAE according to parts by weight.The present invention beats powder using Chinese medicine, and the mode that sesame oil reconciles specifies drug ratio in prescription, utmostly retains effective ingredient, reconciliation and excipient using sesame oil are stablized effective component release and are mitigated, have clearing heat and detoxicating, the effect of swelling and pain relieving, and paste saves conveniently, can take at any time.By Long-term Clinical Observation, burned patient, after affected part applies the paste, patient's redness, the symptom of pain of minor scald can obviously relieve even symptom and disappear substantially.It for the patient of moderate scald, can be relieved pain rapidly after the use of this paste, eliminate the bubble occurred after wound, effect is obviously promoted to the regeneration of surface of a wound skin tissue.
Description
Technical field
The invention belongs to clinical medicine technical fields more particularly to a kind of burn and scald medicament and preparation method thereof.
Background technique
Burn and scald, which refers to, to be caused in human body because of boiling water (oil), raging fire, light, electricity, radioactive ray or the chemical substance the effects of
Damage, it includes skin or mucosa injury, and serious person may injure subcutaneous tissue, be it is most common in routine work and life and
One of extremely complex injury.If handling in some cases not in time, undesirable consequence will lead to.
The weight at the position of the main root root burn and scald of the severity of burn and scald, size and burn and scald judges.
Depth is pressed by burn and scald, is generally divided into three degree:
Once burn and scald: epidermis is only injured, injured rubefaction, swelling, feeling of pain is stronger, but appearance without blister.
Two degree of burn and scalds: injuring skin corium, and part is red and swollen, generates heat, in great pain, there is obvious bubble.
Three degree of burn and scalds: full thickness skin includes that fat, bone and the muscle below skin all come to harm, and skin is burned black, bad
Extremely, because having damaged nerve, pain is not violent instead.
The chemicals for the treatment of burn and scald are more at present, such as antibacterials, silver salt, main function are anti-inflammatory, antibacterial, town
Bitterly, but there are certain adverse reaction, promote the surface of a wound of deep burn that the power of regeneration of skin tissue is poor, treats burnt degree
In place of the deficiencies of consumer edema effect is undesirable；" the U.S. treasured board " ointment for treating scald, Jiangxi produced with common burn, scald plaster such as Beijing
The treatment such as " new Asia is new " ointment for treating scald produced curative effect is not satisfactory.Healing time is long, and curative effect is slow, and price, patient's use at
This height cures scar sometimes.And Chinese medicine is relieving pain, detumescence, there is obvious characteristic and excellent in terms of wound healing
Gesture, possesses clearing heat and detoxicating, and ointment for treating burn and scald the effects of swelling and pain relieving, myogenic is often used.As Chinese Patent Application No. is
95110884.0 " a kind of Chinese medicine for treating burn, scald " is using more than ten kinds of centipede, scorpio, day Lan Xing, the root of Dahurain angelica, coptis etc.
Powder made of prepared from traditional Chinese medicines, it reduces the production cost expense of ointment accordingly, and it is negative to alleviate the economy that patient uses
Load, still, treatment use or more complex, also to concoct and use with diluent, text for patient, especially to rural area
The not high patient of change degree, if allotment it is not satisfactory if be extremely difficult to the optimum efficiency for the treatment of, and use very numb
It is tired of, unsatisfactory curative effect, treatment time is long.
In conclusion problem of the existing technology is:
(1) at present treatment burn and scald chemicals it is more, there are certain adverse reaction, treat burnt degree detumescence,
In place of the deficiencies of analgesic effect is undesirable.
(2) common ointment healing time is long at present, and curative effect is slow, and price, and patient's use cost is high, and meeting when healing
Scar.
(3) gained Chinese medicine preparation active ingredient is not known, and weight is unstable.
Therefore the effective component for being badly in need of a kind of pair of rapid recovery burn and scald redness pain and wound repairing skin tissue at present is bright
Really, the stable paste of weight.
Summary of the invention
In view of the problems of the existing technology, the present invention provides a kind of burn and scald medicaments and preparation method thereof.
The invention is realized in this way a kind of burn and scald medicament, the burn and scald medicament is according to parts by weight by rheum officinale 15-
30 parts, 15-30 parts of gypsum rubrum, 10-20 parts of gypsum, 20-30 parts of the coptis and 10-20 parts of charred RADIX SANGUISORBAE compositions.
Another object of the present invention is to provide a kind of preparation method of burn and scald medicament, the burn and scald medicament
Preparation method the following steps are included:
Step 1: by weight, by 15-30 parts of rheum officinale, 15-30 parts of gypsum rubrum, 10-20 parts of gypsum, 20-30 parts of the coptis and
10-20 parts of charred RADIX SANGUISORBAE drying；
Step 2: said medicine is sterilized；
Step 3: all drugs are ground as smalls, are sieved with 100 mesh sieve；
Step 4: medicine end is reconciled with 30-60 parts of sesame oil, storage bottle is spare.
Further, the burn and scald preparation spreads on affected part.
In conclusion advantages of the present invention and good effect are as follows:
This paste beats powder using Chinese medicine, and the mode that sesame oil reconciles specifies drug ratio in prescription, utmostly retains drug
Effective component, reconciliation and excipient using sesame oil, make effective component release stablize mitigate, have it is clearing heat and detoxicating, swelling and pain relieving
Effect, and paste saves conveniently, can take at any time.
By Long-term Clinical Observation, burned patient, after affected part applies the paste, the patient of minor scald is red and swollen, pain
Symptom can obviously relieve even symptom disappear substantially.For the patient of moderate scald, can be relieved pain rapidly after the use of this paste,
The bubble occurred after wound is eliminated, effect is obviously promoted to the regeneration of surface of a wound skin tissue.
The present invention uses the dosage form of Chinese medicine ointment, and ointment can make drug persistently play treatment being locally slowly absorbed
Effect, drug is smashed and is ground, and can be increased medical surfaces product, be increased dissolution rate, reduce crude drug consumption；Meanwhile sesame oil is directly adjusted
The mode of sum can be done directly on affected part part, and thin deposited increase local comfort degree reduces drug waste；Paste is easy to save, behaviour
Facilitate, is easy to grasp, facilitates Emergency use.
Detailed description of the invention
Fig. 1 is the preparation method flow chart of burn and scald medicament provided in an embodiment of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Burn and scald medicament provided in an embodiment of the present invention according to parts by weight by 15-30 parts of rheum officinale, 15-30 parts of gypsum rubrum,
10-20 parts of gypsum, 20-30 parts of the coptis and 10-20 parts of charred RADIX SANGUISORBAE compositions.
Rheum officinale, which has, attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances and other effects.Modern research shows that big xanthorrhiza shape
Furthermore stem still contains tannin containing Anthraquinone derivatives such as Rhein, rheum emodin, Chrysophanol, aloe-emodin, Physcions
Deng.Rheum officinale rhizomes and root have the effects of clearing away heat and purging, broken product stasis eliminatings, antibacterial anti-inflammatory.Gypsum rubrum also can clearing heat-fire.Gypsum
Clearing heat-fire, relieving restlessness are quenched the thirst, restrain myogenic, modern research shows that can inhibit heat-regulating centers, mitigate skeletal muscle excitability,
Vasopermeability is reduced, therefore has the effects of antipyretic, antispastic, anti-inflammatory.Coptis bitter, it is cold in nature.Return heart, spleen, stomach, liver, gallbladder, large intestine
Through.Can heat-clearing and damp-drying drug, purging fire for removing toxin.Garden burnet belongs to hemostatic, has cooling blood and hemostasis, and removing toxic substances sore effect is that treatment blood-head is each
The kind common drugs such as bleeding and scald.
Application principle of the invention is explained in detail with reference to the accompanying drawing.
Burn and scald medicament provided in an embodiment of the present invention is made of rheum officinale, gypsum rubrum, gypsum, the coptis and garden burnet.
As shown in Figure 1, the preparation method of burn and scald medicament provided in an embodiment of the present invention the following steps are included:
S101: by weight, by 15-30 parts of rheum officinale, 15-30 parts of gypsum rubrum, 10-20 parts of gypsum, 20-30 parts of the coptis and ground
10-20 parts of elm charcoal drying；
S102: said medicine is sterilized；
S103: all drugs are ground as smalls, are sieved with 100 mesh sieve；
S104: medicine end is reconciled with 30-60 parts of sesame oil, storage bottle is spare.
Rheum officinale, gypsum rubrum, gypsum, the coptis and charred RADIX SANGUISORBAE composition, all medicines are end, and sesame oil reconciles, and spread on affected part.
Effect: effect: clearing heat and detoxicating, swelling and pain relieving.
Application effect of the invention is explained in detail below with reference to Pharmacological Analysis.
Rheum officinale: rheum officinale rhizomes is containing dissociated anthraquinones such as Rhein, rheum emodin, Chrysophanol, aloe-emodin, Physcions
Derivative, furthermore still containing tannin etc..Its antibiotic effective ingredient: Rhein, rheum emodin, aloe-emodin.Antibacterial mechanism: shadow
Ring the enzyme system of folic acid；Inhibit bacterial nucleic acid and protein synthesis；Inhibit bacterium living beings oxidase system；Inducement interferon.
Gypsum rubrum: gypsum rubrum is salty-cold, can heat-clearing and fire-reducing, sharp key, detumescence.Erysipelas is controlled, is scalded.Modern pharmacodynamic study is not
It is more, but the past traditional Chinese medicine ancient books and records are recorded in treatment burn-scald medicine prescription, and gypsum rubrum is key agents.
Gypsum: gypsum clearing heat-fire, relieving restlessness are quenched the thirst, and myogenic are restrained, modern research shows that can inhibit in body heat regulation
Pivot the excitability for mitigating skeletal muscle, reduces vasopermeability, therefore has the effects of antipyretic, antispastic, anti-inflammatory.
The coptis: confrontation bacteriotoxin reduces staphylococcus aureus coagulase, hemolysin potency, reduces Escherichia coli
Virulence.Inhibit kinds of experiments inflammation, effective component is jamaicin, and Anti-inflammatory Mechanism is related with stimulation corticotropin release.
Garden burnet: in vitro test shows garden burnet to Escherichia coli, bacterium sonnei, proteus, typhoid bacillus, paratyphoid
Bacillus, Pseudomonas aeruginosa, comma bacillus, tubercle bacillus, diplococcus meningitidis etc. have antibacterial action, fry charcoal more the clinic and are used as medicine.Ground
Elm contains a large amount of tannins and saponin, and antimicrobial spectrum is wide, but bacteriostasis lowers after high-temperature process.
Concrete application case study on implementation is explained in detail application effect of the invention below.
Zhang, in July, 2016 is medical, and 41 years old, the right slight boiled water of skin of dorsum of hand was scalded more than 3 hours.Existing disease are as follows: right upper extremity hand
Back is red and swollen, there is a bubble, parts against wear, Pi Wengao, and skin touching has feeling of pain.Disposition is not given from after scald.Then the medicine is used
Agent is applied with, and timing is advised to spread on affected part.Follow-up after 3 days, feedback effects are obvious, and symptom is relieved, and without discomfort.After a week
Follow-up, patient indicate that right hand malaise symptoms have disappeared, do not stay scar.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (3)
1. a kind of burn and scald medicament, which is characterized in that the burn and scald medicament is according to parts by weight by 15-30 parts of rheum officinale, Han Shui
15-30 parts of stone, 10-20 parts of gypsum, 20-30 parts of the coptis and 10-20 parts of charred RADIX SANGUISORBAE compositions.
2. a kind of preparation method of burn and scald medicament as described in claim 1, which is characterized in that the preparation of the burn and scald medicament
Method the following steps are included:
Step 1: by weight, by 15-30 parts of rheum officinale, 15-30 parts of gypsum rubrum, 10-20 parts of gypsum, 20-30 parts of the coptis and garden burnet
10-20 parts of charcoal drying；
Step 2: said medicine is sterilized；
Step 3: all drugs are ground as smalls, are sieved with 100 mesh sieve；
Step 4: medicine end is reconciled with 30-60 parts of sesame oil, storage bottle is spare.
3. the preparation method of burn and scald preparation as claimed in claim 2, which is characterized in that the burn and scald preparation spreads on trouble
Place.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910154001.4A CN109674865A (en) | 2019-03-01 | 2019-03-01 | A kind of burn and scald medicament and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910154001.4A CN109674865A (en) | 2019-03-01 | 2019-03-01 | A kind of burn and scald medicament and preparation method thereof |
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| Publication Number | Publication Date |
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| CN109674865A true CN109674865A (en) | 2019-04-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910154001.4A Pending CN109674865A (en) | 2019-03-01 | 2019-03-01 | A kind of burn and scald medicament and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111514203A (en) * | 2020-06-21 | 2020-08-11 | 南京中医药大学 | Application of garden burnet charcoal in preventing and treating tinea corporis, tinea cruris, tinea manus and tinea pedis |
-
2019
- 2019-03-01 CN CN201910154001.4A patent/CN109674865A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 于作洋等: "《国医大家刘弼臣学术经验集成》", 31 January 2013, 中国中医药出版社 * |
| 赵旭涛等: "《实用中医诊疗学》", 28 February 2006, 吉林科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111514203A (en) * | 2020-06-21 | 2020-08-11 | 南京中医药大学 | Application of garden burnet charcoal in preventing and treating tinea corporis, tinea cruris, tinea manus and tinea pedis |
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Application publication date: 20190426 |