CN109669033A - A kind of immune affinity column operating device - Google Patents
A kind of immune affinity column operating device Download PDFInfo
- Publication number
- CN109669033A CN109669033A CN201710963224.6A CN201710963224A CN109669033A CN 109669033 A CN109669033 A CN 109669033A CN 201710963224 A CN201710963224 A CN 201710963224A CN 109669033 A CN109669033 A CN 109669033A
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- China
- Prior art keywords
- affinity column
- operating device
- cabinet
- immune affinity
- injection needle
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000000243 solution Substances 0.000 claims abstract description 30
- 239000007788 liquid Substances 0.000 claims abstract description 23
- 239000007924 injection Substances 0.000 claims abstract description 18
- 238000002347 injection Methods 0.000 claims abstract description 18
- 238000004140 cleaning Methods 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000011084 recovery Methods 0.000 abstract description 13
- 230000003749 cleanliness Effects 0.000 abstract description 4
- 238000005406 washing Methods 0.000 abstract description 4
- 238000002203 pretreatment Methods 0.000 abstract description 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 238000004886 process control Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
A kind of immune affinity column operating device, it is related to a kind of improvement of liquid chromatogram pre-treatment instrument, and in particular to a kind of immune affinity column operating device.Solution pallet is located at enclosure top rear portion, saves the space for placing solution bottle；Service sink is located at the front end of cabinet, in addition it is the cleaning part for injection needle that a part of service sink, which is used to place the part of sample bottle and returnable bottle,.Corresponding cylindrical hole is arranged according to the position of injection needle in the described cleaning part, and injection needle is placed directly in hole when cleaning, cleans while realizing needle inside and outside wall.It is long that it solves the mode of operation time existing for existing immune affinity column, flow rate of liquid is uncontrollable, it is influenced by sample viscosity and cleanliness, it provide a kind of multichannel, flow rate of liquid is controllable, realize positive pressure loading, sample recovery rate is high and stable and consistent, pipeline is capable of washing, immune affinity column operating device of low-residual.
Description
Technical field
The present invention relates to a kind of improvement of liquid chromatogram pre-treatment instrument, and in particular to a kind of affine in immunity column operation dress
It sets.
Background technique
Immunoaffinity chromatography (IAFC) immunoaffinity chromatography is another using the side in antigen-antibody as the affine absorption of aglucon
The separation system of side is known as immunoaffinity chromatography.
The operating device of existing immune affinity column is to be connect by injector syringe with affine top end, then will connection
Two good components are fixed on bracket, so that sample and required elution solution is flowed through affinity column in such a way that liquid is self-possessed, this
The kind mode of operation time is long, and flow rate of liquid is uncontrollable, is influenced by sample viscosity and cleanliness, solution can not be made repeatedly to pass through
Affinity column, sample recovery rate are big by the intervention difference of people.
Summary of the invention
In view of the defects and deficiencies of the prior art, the present invention intends to provide a kind of immune affinity column operating device,
It provide a kind of multichannel, flow rate of liquid is controllable, realize positive pressure loading, liquid can it is repeated multiple times by affinity column,
Sample recovery rate is high and stable and consistent, pipeline is capable of washing, immune affinity column operating device of low-residual.
To achieve the above object, the present invention is using following technical scheme: it include LCD touch control flow 1, cabinet 2,
Power control button 3, three-way magnetic valve 4, Multi-channel switching valve 5, six channel switching valves 6, syringe pump 7, solution pallet 8, injection
Needle fixed frame 9, service sink 13, column attachment device 14, solution pallet 8 are located at 2 top rear portion of cabinet, save and place solution bottle
Space；Service sink 13 is located at the front end of cabinet 1, and a part of service sink 13 is used to place the part 12 of sample bottle and returnable bottle,
It in addition is the cleaning part 10 for injection needle.
Corresponding cylindrical hole is arranged according to the position of injection needle in the cleaning part 10, and injection needle is direct when cleaning
It is placed in hole, is cleaned while realizing needle inside and outside wall.
The service sink 13 is provided with liquid reflux slot and output channel.It is exhausted directly to outside instrument for waste liquid will to be cleaned
Waste liquid barrel in；This device is to facilitate taking for sample and returnable bottle, is also convenient for the cleaning of needle, improves operating efficiency, avoids
Cross contamination.
The column attachment device 14 includes column connection both ends and fixed frame two parts, and center pillar connects both ends according to affine
Column shape specific customization is processed into required taper, facilitates the connection at affinity column both ends, can be realized by way of directly plugging
It mounts and separates, pipeline is fixed and attached in flow path system by the other side at column connection both ends by universal joint；Fixed frame
Part can place more affinity columns simultaneously, and each affinity column is connect side pressure with column by adjustable tabletting after affinity column placement
Tightly, guarantee to reveal under system high pressure.
The pipe-line system of the Multi-channel switching valve 5, syringe pump 7, three-way magnetic valve 4 and six channel switching valves 6 composition.
The switching of different solutions may be implemented by switching valve, the switching in different channels may be implemented in solenoid valve, and syringe pump ensure that molten
The accuracy of liquid sample volume and the stable and consistent of flow velocity.Pipeline uses polytetrafluoroethylene material, and injection needle is 316L stainless steel
Material, it is corrosion-resistant, it is ensured that solution is not contaminated, and entire flow path realizes solution quantitative, constant speed, multiple by specific process control
Immune affinity column can be passed through back and forth, realize the high-recovery of sample.Entire flow path realizes solution by specific process control
Quantitative, constant speed repeatedly can pass through immune affinity column back and forth, realize the high-recovery of sample.
Multiple Multi-channel switching valves 2 are mounted on the front panel of immune affinity column cabinet 1, multiple three-way magnetic valves
4 be mounted on cabinet panel it is adjacent with six channel switching valves 6, syringe pump 7 be mounted on it is adjacent with switching valve on 1 panel of cabinet, parent
Device, which is connected and fixed, with column is located at cabinet front end.Convenient for the replacement of affinity column, syringe pump, switching valve, solenoid valve and affinity column connect
Connect the flow path system that fixed device is made up of whole device pipeline.
The solution pallet 8 is located at 1 top rear of cabinet, in a concave shape.For placing various solution, not only save
The placement space of solvent bottle, and shorten flow path length.
Switching valve of the invention, syringe pump, solenoid valve, solvent recovery unit are all that hidden is laid, and flow path is to greatest extent
It is blocked, keeps immune affinity column operating device succinct, neat, it is easy to use.
After adopting the above technical scheme, the invention has the following beneficial effects: it solves operation side existing for existing immune affinity column
The formula time is long, and flow rate of liquid is uncontrollable, is influenced by sample viscosity and cleanliness, solution can not be made repeatedly to pass through affinity column,
Sample recovery rate is intervened the big technical problem of difference by people, provide a kind of multichannel, flow rate of liquid is controllable, realize positive pressure
Loading, liquid can it is repeated multiple times by affinity column, sample recovery rate is high and stable and consistent, pipeline it is capable of washing, low residual
The immune affinity column operating device stayed.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention without any creative labor, may be used also for those of ordinary skill in the art
To obtain other drawings based on these drawings.
Fig. 1 is structural schematic diagram of the invention；
Fig. 2 is the left view of Fig. 1；
Fig. 3 is the top view of Fig. 1；
Fig. 4 is axonometric drawing of the invention；
Fig. 5 is the structural schematic diagram of service sink 13 in the present invention；
Fig. 6 is the structural schematic diagram of main attachment device 14 in invention.
Description of symbols: LCD touch control flow 1, cabinet 2, power control button 3, three-way magnetic valve 4,16 channels
Switching valve 5, six channel switching valves 6, syringe pump 7, solution pallet 8, injection needle fixed frame 9, service sink 13, column attachment device 14.
Specific embodiment
Referring to shown in Fig. 1-Fig. 6, present embodiment the technical solution adopted is that: it is by LCD touch control flow 1, machine
Case 2, power control button 3, three-way magnetic valve 4,16 channel switching valves 5, six channel switching valves 6, syringe pump 7, solution pallet
8, injection needle fixed frame 9, service sink 13, column attachment device 14 form, and solution pallet 8 is located at 2 top rear portion of cabinet, saves and put
Set the space of solution bottle；Service sink 13 is located at the front end of cabinet 1, and a part of service sink 13 is for placing sample bottle and returnable bottle
Part 12, be in addition the cleaning part 10 for injection needle.
Corresponding cylindrical hole is arranged according to the position of injection needle in the cleaning part 10, and injection needle is direct when cleaning
It is placed in hole, is cleaned while realizing needle inside and outside wall.
The service sink 13 is provided with liquid reflux slot and output channel.It is exhausted directly to outside instrument for waste liquid will to be cleaned
Waste liquid barrel in；This device is to facilitate taking for sample and returnable bottle, is also convenient for the cleaning of needle, improves operating efficiency, avoids
Cross contamination.
The column attachment device 14 includes column connection both ends and fixed frame two parts, and center pillar connects both ends according to affine
Column shape specific customization is processed into required taper, facilitates the connection at affinity column both ends, can be realized by way of directly plugging
It mounts and separates, pipeline is fixed and attached in flow path system by the other side at column connection both ends by universal joint；Fixed frame
Part can place more affinity columns simultaneously, and each affinity column is connect side pressure with column by adjustable tabletting after affinity column placement
Tightly, guarantee to reveal under system high pressure.
The pipeline system of the 16 channel switching valves 5, syringe pump 7, three-way magnetic valve 4 and six channel switching valves 6 composition
System.The switching of different solutions may be implemented by switching valve, the switching in different channels may be implemented in solenoid valve, and syringe pump ensure that
The accuracy of solution sample volume and the stable and consistent of flow velocity.Pipeline uses polytetrafluoroethylene material, and injection needle is 316L stainless steel
Material, it is corrosion-resistant, it is ensured that solution is not contaminated, and entire flow path realizes solution quantitative, constant speed, more by specific process control
It is secondary to pass through immune affinity column back and forth, realize the high-recovery of sample.Entire flow path is realized molten by specific process control
Liquid is quantitative, constant speed, repeatedly can pass through immune affinity column back and forth, realizes the high-recovery of sample.
Multiple 16 channels switching valve 2 is mounted on the front panel of immune affinity column cabinet 1, multiple threeway electromagnetism
Valve 4 be mounted on cabinet panel it is adjacent with six channel switching valves 6, syringe pump 7 be mounted on it is adjacent with switching valve on 1 panel of cabinet,
Affinity column is connected and fixed device and is located at cabinet front end.Convenient for the replacement of affinity column, syringe pump, switching valve, solenoid valve and affinity column
It is connected and fixed the flow path system that device is made up of whole device pipeline.
The solution pallet 8 is located at 1 top rear of cabinet, in a concave shape.For placing various solution, not only save
The placement space of solvent bottle, and shorten flow path length.
Switching valve of the invention, syringe pump, solenoid valve, solvent recovery unit are all that hidden is laid, and flow path is to greatest extent
It is blocked, keeps immune affinity column operating device succinct, neat, it is easy to use.
After adopting the above technical scheme, the invention has the following beneficial effects: it solves operation side existing for existing immune affinity column
The formula time is long, and flow rate of liquid is uncontrollable, is influenced by sample viscosity and cleanliness, solution can not be made repeatedly to pass through affinity column,
Sample recovery rate is intervened the big technical problem of difference by people, provide a kind of multichannel, flow rate of liquid is controllable, realize positive pressure
Loading, liquid can it is repeated multiple times by affinity column, sample recovery rate is high and stable and consistent, pipeline it is capable of washing, low residual
The immune affinity column operating device stayed.
The above is only used to illustrate the technical scheme of the present invention and not to limit it, and those of ordinary skill in the art are to this hair
The other modifications or equivalent replacement that bright technical solution is made, as long as it does not depart from the spirit and scope of the technical scheme of the present invention,
It is intended to be within the scope of the claims of the invention.
Claims (7)
1. a kind of immune affinity column operating device, it is characterised in that: it includes LCD touch control flow (1), cabinet (2), power supply
Control button (3), three-way magnetic valve (4), 16 channel switching valves (5), six channel switching valves (6), syringe pump (7), solution support
Disk (8), injection needle fixed frame (9), service sink (13), column attachment device (14), after solution pallet (8) is located at cabinet (2) top
Portion；Service sink (13) is located at the front end of cabinet (1), and a part of service sink (13) is used to place the part of sample bottle and returnable bottle
(12), in addition it is cleaning part (10) for injection needle.
2. a kind of immune affinity column operating device according to claim 1, it is characterised in that: the cleaning part (10)
Corresponding cylindrical hole is set according to the position of injection needle, injection needle is placed directly in hole when cleaning.
3. a kind of immune affinity column operating device according to claim 1, it is characterised in that: the service sink (13) is set
It is equipped with liquid reflux slot and output channel.
4. a kind of immune affinity column operating device according to claim 1, it is characterised in that: the column attachment device
(14) comprising column connection both ends and fixed frame two parts, center pillar connects both ends and is processed into institute according to affinity column shape specific customization
Pipeline is fixed and attached in flow path system by the other side of the taper needed, column connection both ends by universal joint；Fixed part
More affinity columns can be placed simultaneously by dividing.
5. a kind of immune affinity column operating device according to claim 1, it is characterised in that: the 16 channels switching
The pipe-line system of valve (5), syringe pump (7), three-way magnetic valve (4) and six channel switching valves (6) composition.
6. a kind of immune affinity column operating device according to claim 1, it is characterised in that: multiple 16 channels
Switching valve (2) is mounted on the front panel of immune affinity column cabinet (1), and multiple three-way magnetic valves (4) are mounted on cabinet panel
Adjacent with six channel switching valves (6), syringe pump (7) is mounted on adjacent with switching valve on cabinet (1) panel, and affinity column is connected and fixed
Device is located at cabinet front end.
7. a kind of immune affinity column operating device according to claim 1, it is characterised in that: the solution pallet (8)
It is in a concave shape positioned at cabinet (1) top rear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710963224.6A CN109669033A (en) | 2017-10-17 | 2017-10-17 | A kind of immune affinity column operating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710963224.6A CN109669033A (en) | 2017-10-17 | 2017-10-17 | A kind of immune affinity column operating device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109669033A true CN109669033A (en) | 2019-04-23 |
Family
ID=66140331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710963224.6A Pending CN109669033A (en) | 2017-10-17 | 2017-10-17 | A kind of immune affinity column operating device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109669033A (en) |
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|---|---|---|---|---|
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| JP2007309938A (en) * | 2006-05-17 | 2007-11-29 | Amr Inc | Needle unit for sample injection, and sample suction/cleaning device of syringe using the same |
| CN201161989Y (en) * | 2007-08-14 | 2008-12-10 | 百奇生物科技(上海)有限公司 | Multicenter protein compatible chromatography purification instrument |
| JP2010271300A (en) * | 2009-04-23 | 2010-12-02 | National Institute Of Advanced Industrial Science & Technology | Protein separating and refining device using liquid chromatography |
| CN103293253A (en) * | 2013-05-24 | 2013-09-11 | 中国科学院过程工程研究所 | Efficient purification-analysis system for biotechnological medicine and medicine separation detection method thereof |
| CN204151270U (en) * | 2014-10-30 | 2015-02-11 | 江苏汉邦科技有限公司 | A kind of industrial preparation scale protein separation system |
| CN104407083A (en) * | 2014-11-28 | 2015-03-11 | 天津博纳艾杰尔科技有限公司 | Full-automatic separation system and application of full-automatic separation system in separation of polar components in edible oil |
| US20160136543A1 (en) * | 2013-07-05 | 2016-05-19 | Hitachi, Ltd. | Separation device and separation method |
| CN106872612A (en) * | 2015-12-11 | 2017-06-20 | 中国科学院大连化学物理研究所 | A kind of Full automatic array solid-phase extraction device |
| CN206305137U (en) * | 2016-11-18 | 2017-07-07 | 力合科技（湖南）股份有限公司 | A kind of outer wall cleaning device for sample introduction needle |
-
2017
- 2017-10-17 CN CN201710963224.6A patent/CN109669033A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005121384A (en) * | 2003-10-14 | 2005-05-12 | Tosoh Corp | Channel switching valve and liquid chromatograph |
| JP2007309938A (en) * | 2006-05-17 | 2007-11-29 | Amr Inc | Needle unit for sample injection, and sample suction/cleaning device of syringe using the same |
| CN201161989Y (en) * | 2007-08-14 | 2008-12-10 | 百奇生物科技(上海)有限公司 | Multicenter protein compatible chromatography purification instrument |
| JP2010271300A (en) * | 2009-04-23 | 2010-12-02 | National Institute Of Advanced Industrial Science & Technology | Protein separating and refining device using liquid chromatography |
| CN103293253A (en) * | 2013-05-24 | 2013-09-11 | 中国科学院过程工程研究所 | Efficient purification-analysis system for biotechnological medicine and medicine separation detection method thereof |
| US20160136543A1 (en) * | 2013-07-05 | 2016-05-19 | Hitachi, Ltd. | Separation device and separation method |
| CN204151270U (en) * | 2014-10-30 | 2015-02-11 | 江苏汉邦科技有限公司 | A kind of industrial preparation scale protein separation system |
| CN104407083A (en) * | 2014-11-28 | 2015-03-11 | 天津博纳艾杰尔科技有限公司 | Full-automatic separation system and application of full-automatic separation system in separation of polar components in edible oil |
| CN106872612A (en) * | 2015-12-11 | 2017-06-20 | 中国科学院大连化学物理研究所 | A kind of Full automatic array solid-phase extraction device |
| CN206305137U (en) * | 2016-11-18 | 2017-07-07 | 力合科技（湖南）股份有限公司 | A kind of outer wall cleaning device for sample introduction needle |
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| TA01 | Transfer of patent application right |
Effective date of registration: 20230321 Address after: 214000 Area B, Floor 1, No. 1719-5, Huishan Avenue, Huishan Economic Development Zone, Wuxi City, Jiangsu Province Applicant after: Wuxi Guanyi Biotechnology Co.,Ltd. Address before: 100000 room 2519, building 12, yard 22, Fengtai District, Beijing Applicant before: PURUIBANG (BEIJING) TECHNOLOGY Co.,Ltd. |
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Application publication date: 20190423 |
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