CN109646544B

CN109646544B - Traumatic injury medicine and preparation method thereof

Info

Publication number: CN109646544B
Application number: CN201811527651.0A
Authority: CN
Inventors: 张钦明
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-03-05
Filing date: 2019-03-05
Publication date: 2021-08-13
Anticipated expiration: 2039-03-05
Also published as: CN109646544A

Abstract

The invention discloses a medicine for treating traumatic injury and a preparation method thereof, relating to the field of traditional Chinese medicines. The traumatic injury medicine provided by the invention is prepared by selecting more than ten Chinese medicinal materials of pseudo-ginseng, cortex acanthopanacis, eucommia bark, lycopodium clavatum, frankincense, myrrh, dragon's blood, rhizoma cibotii, centipede, caulis spatholobi and the like as raw materials, reasonably mixing, scientifically processing and then externally applying to an affected part, thereby achieving the effects of activating blood circulation to dissipate blood stasis, relieving swelling and pain, reuniting bones and muscles and clearing and activating channels and collaterals; the microcirculation of the affected part is improved by mobilizing the regeneration capacity of the tissues of the human body, so that the aims of promoting the formation of callus, accelerating the healing of wounds and recovering skills are fulfilled. Compared with the traditional treatment method, the traditional Chinese medicine composition has the advantages of good curative effect, low cost, short recovery time and no sequelae after recovery, and has outstanding curative effect on elderly patients with big age, weak constitution and complex basic diseases.

Description

Traumatic injury medicine and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a medicine for treating traumatic injury and a preparation method thereof.

Background

Fracture is a multiple surgical disease, and is particularly common in the middle-aged and the elderly. Incomplete/complete fracture of bone and even comminuted change are mostly caused by serious trauma such as traumatic injury, impact injury, and smashing injury. The main symptoms are pain, blood stasis/bleeding, swelling, malposition, deformity, functional disorder, abnormal movement and grating bone sound. Long course of disease, slow recovery, great pain and more sequelae.

The traditional western medicine treatment method comprises operation reduction, plaster fixation and natural recovery. Especially for middle-aged and elderly people, due to calcium loss and osteoporosis, local microcirculation is poor, bone regeneration ability is weak, disease course is long, recovery is slow, and sequelae are many. The recovery period is as long as several months, the bone growth period is 1-3 years, the treatment uncertainty of secondary operation and secondary injury exists, and the risk and economic burden of patients are increased.

According to traditional Chinese medicine, the fracture injury part is subjected to blood stasis and swelling, meridian blockage and qi and blood blockage, and the treatment principle mainly comprises the functions of promoting blood circulation to remove blood stasis and promoting qi circulation to dissipate. The treatment of fracture healing is the primary treatment of detumescence and stasis dissipation. Further, the purposes of relieving pain, removing blood stasis, promoting tissue regeneration, strengthening bones and muscles and reuniting bones and muscles are achieved by dredging qi and blood and improving blood circulation of the affected part, and the formation of callus is promoted. And the muscles and joints are relaxed and the collaterals are activated, so that the adjacent tissues and joints of the fracture part can freely and flexibly move, and the function of the fracture part in the next day is recovered.

Disclosure of Invention

The first invention of the invention is that: aiming at the existing problems, the traumatic injury medicine is an external pure traditional Chinese medicine preparation, can quickly reduce swelling and remove blood stasis, strengthen blood circulation, improve microcirculation, promote the quick recovery of tissue injury around fracture and the quick formation of callus, does not leave sequelae after recovery, has short time and low cost, and is particularly suitable for middle-aged and old patients.

The second object of the present invention is to provide a method for producing the traumatic injury drug described above, which promotes better efficacy.

The technical scheme adopted by the invention is as follows:

a medicine for treating traumatic injury comprises, by mass, 50-70 parts of pseudo-ginseng, 25-35 parts of cortex acanthopanacis, 25-35 parts of eucommia ulmoides, 25-35 parts of lycopodium clavatum, 20-30 parts of frankincense, 20-30 parts of myrrh, 20-30 parts of dragon's blood, 10-20 parts of rhizoma cibotii, 5-15 parts of centipede and 200 parts of caulis spatholobi.

The traumatic injury medicine of the invention also comprises 20-40 parts of earthworm, 5-15 parts of saffron, 5-15 parts of scorpion, 10-20 parts of cape jasmine, 10-20 parts of drynaria rhizome, 10-20 parts of dipsacus root, 5-15 parts of ground beetle and 10-20 parts of click beetle by mass.

The invention relates to a medicine for treating traumatic injury, which comprises the following raw materials of 60 parts of pseudo-ginseng, 30 parts of cortex acanthopanacis, 30 parts of eucommia bark, 30 parts of lycopodium clavatum, 25 parts of frankincense, 25 parts of myrrh, 25 parts of dragon's blood, 15 parts of rhizoma cibotii, 10 parts of centipede, 180 parts of caulis spatholobi, 30 parts of earthworm, 10 parts of saffron crocus, 10 parts of scorpion, 15 parts of cape jasmine, 15 parts of rhizoma drynariae, 15 parts of dipsacus root, 10 parts of ground beetle and 15 parts of click beetle.

In the invention, the basis for selecting the medicinal materials is as follows:

pseudo-ginseng: contains notoginsenoside and triterpenoid saponin, has effects of removing blood stasis, stopping bleeding, promoting blood circulation, and relieving pain, and is especially used as main ingredient for treating traumatic injury, fracture of bones and muscles, and swelling and pain due to blood stasis.

Earthworm: contains earthworm extract and earthworm thermokalite; cold in nature, entering liver, stomach, lung and bladder meridians; clearing heat, calming liver, relieving asthma, and dredging collaterals, and can be used for treating hyperpyrexia, dysphoria, convulsive epilepsy, convulsion, lung heat, cough and asthma, retention of urine, arthralgia, numbness of limbs, hemiplegia, pyocutaneous disease, toxic swelling, etc.

Centipede: containing histamine-like substances, hemolyzed proteins, tyrosine, formic acid, cholesterol, etc.; warm in nature, entering liver meridian; has effects in calming endogenous wind, relieving spasm, removing toxic substances, resolving hard mass, dredging collaterals, and relieving pain, and can be used for treating rheumatism, suppurative sore, and lymphoid tuberculosis.

Cortex acanthopanacis: contains 4-methoxysalicylaldehyde, fatty acid, and vitamin A-like substance; has the effects of dispelling pathogenic wind, removing dampness, and strengthening tendons and bones, and can be used for treating soreness of waist and legs, and traumatic injury.

Saffron: contains crocin, and crocoquinone glycoside; has the effects of promoting blood circulation, dredging collaterals, removing blood stasis and relieving pain, and can be used for treating traumatic injury, blood stasis and pain.

Eucommia ulmoides: contains gutta Percha, resin, and tannin; enter liver and kidney meridians and strengthen tendons and bones, and are indicated for soreness and pain of waist and knees.

B, common clubmoss herb: contains alkaloid, lycopodine and lycopodine; has effects of dispelling pathogenic wind, promoting diuresis, relieving rigidity of muscles and activating collaterals, and can be used for treating rheumatism bone and muscle pain, sprain gall.

Scorpion: contains various amino acids; pungent and mild; entering liver meridian; xifeng to relieve spasm, counteract toxic pathogen to dissipate nodulation, unblock collaterals to alleviate pain, and is indicated for stubborn arthralgia due to wind-damp, migraine, sore and ulcer, scrofula.

Frankincense: contains resin, gum and volatile oil, and has analgesic effect.

Myrrh: contains resin, volatile oil and gum: has antibacterial, antiinflammatory, and astringent effects. The frankincense and the myrrh have the functions of activating blood and promoting qi circulation, relaxing tendons and activating collaterals, relieving pain and swelling and promoting granulation, and are mainly used for treating traumatic injury and blood stasis and blood coagulation dragon's blood: contains dracorhodin, and demethyl dracorhodin; has effects in promoting blood circulation, dispelling blood stasis, relieving pain, stopping bleeding, healing sore, and promoting granulation, and can be used for treating traumatic injury and arthralgia and myalgia.

Gardenia: is rich in gardenoside (C-A), and has antiinflammatory and repercussive effects.

Rhizoma drynariae: contains hesperidin and hesperetin; walking the kidney meridian, strengthening the bone, and treating injury and pain.

And (3) Himalayan teasel root: contains triterpenoid saponin and iridoid; has effects in inhibiting osteoblast proliferation, bone injury, and osteoporosis, and also has antiinflammatory, antiallergic, and immunity enhancing effects.

Rhizoma cibotii: contains terpenes, steroids, and flavones; has hemostatic, antibacterial, and osteoporosis preventing and treating effects.

Ground beetle: has effects of removing blood stasis, eliminating diseases, and treating wound, and can be used for treating wound and fracture.

Click beetles: pungent taste and mild nature; enters liver and kidney meridians, has the efficacy of strengthening tendons and bones, and is mainly used for treating hand and foot atrophy and weakness.

The traumatic injury medicine is prepared from cortex acanthopanacis, eucommia ulmoides, lycopodium clavatum and radix dipsaci; the rhizoma Cibotii, fructus Gardeniae, rhizoma Drynariae, and click beetle are processed with salt; the Olibanum, Myrrha, and Lumbricus can be processed; the Eupolyphaga Seu Steleophaga is parched for use.

A preparation method of a medicine for treating traumatic injury comprises the following steps: the traumatic injury medicine of any one of claims 1-4 is prepared by pulverizing raw materials, mixing, adding whey, concocting, and naturally fermenting to obtain paste.

The invention relates to a preparation method of a medicine for treating traumatic injury, which comprises the steps of crushing, and sieving with a 200-mesh sieve; 200 portions and 300 portions of the milk powder are added by mass.

The preparation method of the traumatic injury medicine of the invention comprises the fermentation process, wherein the temperature is maintained at 28-32 ℃, and the humidity is 65-75%.

In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:

the invention provides a medicament for treating traumatic injury and process for preparation, wherein the medicament is prepared from multiple Chinese medicinal herbs through proportioning, processing and applying on the affected part, the medicament has the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, promoting reunion of bone, dredging meridian passage. The microcirculation of the affected part is improved by mobilizing the regeneration capacity of the tissues of the human body, so that the aims of promoting the formation of callus, accelerating the healing of wounds and recovering skills are fulfilled. The concrete points are as follows:

1. the traditional operation is performed by using a steel plate to fix the bone position, and plaster is used for fixation, so that the circulation of qi and blood around the fracture part is influenced, qi stagnation and blood stasis and microcirculation are not smooth, poor absorption and blood stasis and swelling at the wound part are caused, callus formation is influenced in a light patient, fracture healing is slow, peripheral tissue necrosis is caused in a heavy patient, and functional disorder is formed. The traumatic injury medicine provided by the invention is an external pure traditional Chinese medicine preparation, does not need an operation, relieves the pain of a patient, can quickly reduce swelling and remove blood stasis, strengthens blood circulation, improves microcirculation, promotes quick recovery of tissue injury around fracture and quick formation of callus, and does not leave sequelae after recovery.

2. The traditional operation steel plate is generally plastered for self-recovery after being fixed, and the steel plate is taken out after one to three years of secondary operation and then is subjected to rehabilitation recovery treatment, so that the time is long, the pain of a patient is relieved, and the treatment cost is high. The traumatic injury medicine provided by the invention can effectively avoid the pain and high cost of secondary operation, and the recovery time is greatly shortened.

3. The traumatic injury medicine provided by the invention is used for treating patients with bone fracture without operation, and has the advantages of short time, low cost and no sequelae.

4. Particularly, the traumatic injury medicine provided by the invention has outstanding curative effects on elderly patients with big age, weak constitution and complex basic diseases. The old patients are difficult to form callus due to calcium loss, osteoporosis and the like, and bed-rest for a long time after fracture easily induces other life-threatening diseases. The traumatic injury medicine provided by the invention acts on the wound surface by dredging the channels and collaterals, and comprehensively regulates the qi and blood circulation of the human body, so that the patient can recover quickly and the pain is small.

Drawings

The invention will now be described, by way of example, with reference to the accompanying drawings, in which:

FIG. 1 is a DR image of a patient's Luo-femoral fracture;

FIG. 2 is a DR image of a patient after a rhodesis operation;

FIG. 3 is a DR image of a patient after taking the traumatic injury drug provided by the present invention for 6 weeks;

FIG. 4 is a DR image of a right ankle avulsion fracture of a patient;

FIG. 5 is a DR image of a patient after taking the traumatic injury medicine of the present invention for 33 days.

Detailed Description

All of the features disclosed in this specification, or all of the steps in any method or process so disclosed, may be combined in any combination, except combinations of features and/or steps that are mutually exclusive.

Any feature disclosed in this specification (including any accompanying claims, abstract) may be replaced by alternative features serving equivalent or similar purposes, unless expressly stated otherwise. That is, unless expressly stated otherwise, each feature is only an example of a generic series of equivalent or similar features.

Example 1

The present embodiment provides a medicine for traumatic injury, which comprises the raw materials of 50g of pseudo-ginseng, 35g of cortex acanthopanacis, 25g of eucommia bark, 35g of lycopodium clavatum, 20g of frankincense, 20g of myrrh, 20g of dragon's blood, 20g of cibotium barometz, 5g of centipede and 160g of caulis spatholobi.

Example 2

The embodiment provides a medicine for treating traumatic injury, which is prepared from the following raw materials of 70g of pseudo-ginseng, 25g of cortex acanthopanacis, 35g of eucommia ulmoides, 25g of lycopodium clavatum, 30g of frankincense, 30g of myrrh, 30g of dragon blood, 10g of rhizoma cibotii, 15g of centipede, 200g of caulis spatholobi, 40g of earthworm, 5g of saffron crocus, 5g of scorpion, 20g of cape jasmine, 10g of rhizoma drynariae, 10g of dipsacus root, 15g of ground beetle and 10g of click beetle.

Example 3

The embodiment provides a medicine for treating traumatic injury, which is prepared from the following raw materials of 55g of pseudo-ginseng, 28g of cortex acanthopanacis, 32g of eucommia ulmoides, 26g of lycopodium clavatum, 22g of frankincense, 24g of myrrh, 28g of dragon blood, 16g of rhizoma cibotii, 8g of centipede, 170g of caulis spatholobi, 20g of earthworm, 15g of saffron crocus, 15g of scorpion, 10g of cape jasmine, 20g of rhizoma drynariae, 20g of dipsacus root, 5g of ground beetle and 20g of click beetle.

Example 4

The embodiment provides a medicine for treating traumatic injury, which is prepared from raw materials of 60g of pseudo-ginseng, 30g of cortex acanthopanacis, 30g of eucommia ulmoides, 30g of lycopodium clavatum, 25g of frankincense, 25g of myrrh, 25g of dragon blood, 15g of cibotium barometz, 10g of centipede, 180g of caulis spatholobi, 30g of earthworm, 10g of saffron crocus, 10g of scorpion, 15g of cape jasmine, 15g of rhizoma drynariae, 15g of dipsacus root, 10g of ground beetle and 15g of click beetle.

Example 5

The embodiment provides a medicine for treating traumatic injury, which is prepared from raw materials of 60g of pseudo-ginseng, 30g of processed cortex acanthopanacis, 30g of processed eucommia ulmoides, 30g of processed lycopodium clavatum, 25g of processed frankincense, 25g of processed myrrh, 25g of dragon's blood, 15g of salted cibotium barometz, 10g of centipede, 180g of caulis spatholobi, 30g of processed earthworm, 10g of saffron crocus, 10g of scorpion, 15g of salted gardenia, 15g of salted rhizoma drynariae, 15g of processed radix dipsaci from Sichuan of China, 10g of fried ground beetle and 15g of salted click beetle.

Example 6

This embodiment provides a method for preparing a traumatic injury drug, which is suitable for preparing the traumatic injury drugs in embodiments 1 to 5, and comprises the following steps:

weighing the raw materials according to the formula ratio, crushing, sieving with a 200-mesh sieve, uniformly mixing, adding 200-300g of whey, blending, and naturally fermenting into a paste medicament in an environment with the temperature of 28-32 ℃ and the humidity of 65-75%.

The traumatic injury medicine provided by the invention is an external preparation, and a paste medicament is applied to an affected part and fixed by a splint, and the medicine is replaced once a week. The medication time is selected according to the actual condition of the patient. The actual use of the patient proves that: the mild patient can be cured in three weeks, and the severe patient can be cured in five weeks.

Example 7

In this example, the safety of the traumatic injury drug provided by the present invention was verified, and a basis for the safety of the preparation was provided.

The experimental method comprises the following steps: (1) toxicology experiments and skin mucosa irritation experiments were performed according to the methods provided in the treatises of Ling Chi et al (Ling Chi, Chen kang Yuan, Zhoujunde, et al. externally applied Chinese medicine refute yellow hydrology research [ J ]. Chinese medicine guidance, 2008,5(33): 5-7.). The microbial colony number is detected by a microbial limit detection method provided in Chinese pharmacopoeia 2015 edition. The results of the experiment are shown in table 1:

TABLE 1 safety test results of traumatic injury drugs

As can be seen from Table 1, the traumatic injury drug provided by the invention is safe and nontoxic, has no skin irritation, and completely meets the requirement of drug safety.

Example 8

The embodiment verifies the effectiveness of the traumatic injury medicine provided by the invention and provides a further basis for the clinical application of the preparation.

In order to verify the curative effect of the traumatic injury medicine provided by the invention, clinical observation and regular inspection are carried out on 100 fracture patients, 50 cases are respectively carried out on a control group and a test group, the control group adopts conventional therapy to treat, and the test group adopts the traumatic injury medicine provided by the invention to treat. The Chinese medicinal composition is effective in relieving symptoms (fracture, blood stasis and swelling and pain), and can be cured by eliminating symptoms (fracture, blood stasis and swelling and pain) and moving without pain.

Wherein, the control group has 28 men and 22 women with the age of 40-78 years, and the curative effect is shown in Table 2; the experimental group comprises 24 men and 26 women, the age is 45-83 years, and the curative effect is shown in Table 3.

TABLE 2 control group treatment

Categories	Number of cases	Effective rate of 3 weeks	5 weeks cure rate
				Open fracture	15	Has no obvious effect	Has no cure
Closed fracture	22	Has no obvious effect	Has no cure
				Bone fracture	13	Has no obvious effect	Has no cure
Total up to	50	0	0

TABLE 3 treatment of the test groups

As shown in Table 2, the effect of treating various subtypes of traumatic injuries by using the conventional treatment method is very poor, and the effective rate in 3 weeks and the cure rate in 5 weeks are zero. As can be seen from Table 3, the traumatic injury treatment medicine provided by the invention has a remarkable effect, the effective rate reaches 100%, and the cure rate reaches 96%. Therefore, the traumatic injury medicine provided by the invention can effectively shorten the treatment time and relieve the pain of patients.

Example 9

This example provides 2 specific examples of treatment with the traumatic injury drug provided by the present invention.

1. Patient Luo Zhi, female, 83 years old.

Traumatic injury and femoral fracture in 2018, 8,5 and 5 days. The medical history includes artificial replacement of femoral head. Symptoms are: fracture, thigh pain, swelling, limited leg movement. Through DR examination image, fracture of femur. The DR image is shown in FIG. 1.

The bone setting position is not fixed by gypsum after the operation of 2018, 8, 6 and 6 days. The DR image is shown in fig. 2.

After operation, the traumatic injury medicine provided by the invention has obvious effect, is fully cured after 6 weeks, and can freely walk out of the bed. A review of the DR image is shown in FIG. 3.

2. Patient Wangzhi, female, 58 years old.

If the ankle joint is accidentally sprained in 2018, 8 and 20 months, the right ankle joint feels pain and swelling immediately, and the right ankle joint is restricted in movement and is pressed and painful. The bone fracture of right ankle bone avulsion is detected by DR image. The DR image is shown in fig. 4.

After the bone-knitting pill is used for 33 days and is rechecked by DR images, the avulsed bone fracture of the right ankle bone is healed, the swelling is reduced, the walking is painless, and no abnormality is found. The DR image is shown in FIG. 5.

The invention is not limited to the foregoing embodiments. The invention extends to any novel feature or any novel combination of features disclosed in this specification and any novel method or process steps or any novel combination of features disclosed.

Claims

1. The traumatic injury medicine is characterized by comprising, by mass, 50-70 parts of pseudo-ginseng, 25-35 parts of cortex acanthopanacis, 25-35 parts of eucommia ulmoides, 25-35 parts of lycopodium clavatum, 20-30 parts of frankincense, 20-30 parts of myrrh, 20-30 parts of dragon blood, 10-20 parts of rhizoma cibotii, 5-15 parts of centipede, 200 parts of caulis spatholobi 160, 20-40 parts of lumbricus, 5-15 parts of saffron crocus, 5-15 parts of scorpion, 10-20 parts of fructus gardeniae, 10-20 parts of rhizoma drynariae, 10-20 parts of dipsacus root, 5-15 parts of ground beeltle and 10-20 parts of click beetle.

2. The traumatic injury drug according to claim 1, wherein the raw materials comprise, by mass, 60 parts of pseudo-ginseng, 30 parts of cortex acanthopanacis, 30 parts of eucommia ulmoides, 30 parts of lycopodium clavatum, 25 parts of frankincense, 25 parts of myrrh, 25 parts of dragon's blood, 15 parts of cibotium barometz, 10 parts of centipede, 180 parts of caulis spatholobi, 30 parts of earthworm, 10 parts of saffron crocus, 10 parts of scorpion, 15 parts of cape jasmine, 15 parts of rhizoma drynariae, 15 parts of dipsacus root, 10 parts of ground beetle and 15 parts of click beetle.

3. The traumatic injury medicine of claim 2, wherein cortex acanthopanacis, cortex eucommiae, lycopodium clavatum and radix dipsaci from Sichuan of China are processed and used; the rhizoma Cibotii, fructus Gardeniae, rhizoma Drynariae, and click beetle are processed with salt; the Olibanum, Myrrha, and Lumbricus can be processed; the Eupolyphaga Seu Steleophaga is parched for use.

4. A preparation method of a medicine for treating traumatic injury is characterized by comprising the following steps: the traumatic injury medicine of any one of claims 1-3 is prepared by pulverizing raw materials, mixing, adding whey, concocting, and naturally fermenting to obtain paste.

5. The process for preparing a medicine for traumatic injury according to claim 4, wherein the medicine is prepared by pulverizing, sieving with 200 mesh sieve; 200 portions and 300 portions of the milk powder are added by mass.

6. The preparation method of the traumatic injury medicine according to claim 5, wherein the temperature is maintained at 28-32 ℃ and the humidity is 65% -75% in the fermentation process.