CN109646415A - It is a kind of can effective calcium-supplement but also the calcium tablet for promoting cell development preparation method - Google Patents
It is a kind of can effective calcium-supplement but also the calcium tablet for promoting cell development preparation method Download PDFInfo
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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Abstract
The invention discloses it is a kind of can effective calcium-supplement but also the calcium tablet for promoting cell development preparation method, include the following steps: raw material into purchase, it examines, it weighs, mixing granulation and drying, tabletting, chip select and packaging, it is divided into two kinds by the calcium tablet that the present invention produces, a kind of suitable children are edible, another kind is suitble to designed for old people, children are when growing up, the phenomenon that often will appear calcium deficiency, the elderly is due to older, the phenomenon that being easy to appear osteoporosis, thus, the present invention produces corresponding calcium tablet for children and the elderly, relative to traditional calcium tablet in the market, it is more easier to absorb, and effect of supplemented calcium is more preferably, simultaneously, this kind of calcium tablet also has the effect of promoting cell development, it is beneficial to the health of people.
Description
Technical field
The present invention relates to calcium tablet product technique field, more particularly to a kind of effective calcium-supplement but also cell development can be promoted
The preparation method of calcium tablet.
Background technique
The blood calcium of normal person maintains 2.18-2.63 mM/ls (9-11 milligrams/decilitre), if being lower than this range,
Then regard as calcium deficiency.
In the developmental process of people, the more universal age bracket of calcium deficiency is divided into juvenile and old.
When child occur following some symptoms when, be just considered as whether calcium deficiency: be not easy to fall asleep, be not easily accessible deep sleep,
Love is cryed, is easily waken up with a start, hidrosis after sleep after sleep；Paroxysmal abdominal pain, diarrhea knot, breastbone pain, " X ' type leg, " O " type leg,
Pigeon breast, nail is greyish white or has white mark；Anorexia, partial eclipse；Daytime irritability is on tenterhooks；Intellectual development is slow, it is late to speak；It learns to walk late, 13
Just start to learn to walk after a month；It in teething evening, just teethes after 10 months, teeth arrangement is not sparse, irregular, close, and tooth is darkly sharp
Shape or zigzag；Hair sparse；Out of condition, easy to catch cold etc..Since the resistance of children is poor, if children's calcium deficiency,
The health of children can be made to be deteriorated, and then be easy to keep children often sick.
After adult, human body just slowly enters the negative calcium balance phase, i.e., calcareous absorption is reduced, excretion increases.The elderly
It is to cause calcium deficiency phenomenon because of the loss of calcium mostly.They have senile dermatosis to itch at the symptom of self diagnosis；Heel pain,
Lumbar vertebrae, cervical vertebra ache；Tooth mobility falls off；Apparent bow-backed, height reduces；Appetite stimulator, digestive tract ulcer, constipation；It is more
Dream, insomnia, agitation, irritability etc..The resistance of the elderly is also poor, if the elderly's calcium deficiency, the influence to health is also larger.
Currently, the calcium tablet occurred in the market is mostly to be suitble to masses edible, without good specific aim, lead to effect of supplemented calcium
It is not good enough, meanwhile, traditional calcium tablet only has the effect of replenishing the calcium, and is unable to reach the effect for promoting cell development, and then to people
Health useful degree it is limited, it is then desired to be improved to this.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and the one kind proposed can effective calcium-supplement
It can promote the preparation method of the calcium tablet of cell development.
To achieve the goals above, present invention employs following technical solutions:
It is a kind of can effective calcium-supplement but also the calcium tablet for promoting cell development preparation method, include the following steps:
S1, raw material is into purchase: raw material includes calcium citrate, vitamine D3, milk powder, linseed meal, dextrin, magnesium stearate and sweet tea
Taste agent, raw material is into after purchase, then cooperates into purchase auxiliary material, and auxiliary material includes starch；
S2 is examined: the raw material in step S1 being sieved with 100 mesh sieve screening, the comparatively fine raw material of particle is filtered out and gives over to
It is spare, cold water 20ml is first added in starch and stirs evenly, then plus about 200ml hot water side trimming stirring, then with 100 meshes
Filtering；
S3 is weighed: the supplementary material in step S2 is weighed to the amount of needs according to the proportion；
S4, mixing granulation and drying: by the supplementary material in step S3 by softwood processed, wet granular processed, dry wet particle, whole
Grain, the process processing that disintegrating agent, wetting agent is added；
S5, tabletting: by the mixture in step S4 by pressure testing, tabletting, sieving process processing；
S6, chip select are simultaneously packed: the tabletting in step S5 being handled by chip select, selects the tabletting for reaching standard, then
Carry out packing processes.
Further, raw material proportioning described in step S3 are as follows: 55-75 parts of calcium citrate, vitamine D3 0.0002-0.0003
Part, 8-12 parts of milk powder, 2-5 parts of linseed meal, 12-15 parts of dextrin, 0.1-0.3 parts of magnesium stearate, 12-14 parts of sweetener.
Further, the sweetener is one of white sugar and xylitol, and the starch supplementary material of addition is 0.5-2 parts.
Further, the step S4:
Softwood processed: by load weighted calcium citrate, vitamine D3, milk powder, linolenic acid powder, sweetener, dextrin are put into CH-10
Several minutes are stirred in mixing machine after mixing, is slowly added into starch slurry stirring, until the suitable softwood of humidity viscosity is made；
Wet granular processed: the softwood made is squeezed into particle from stainless steel mesh with YK-60 oscillating granulator；
Dry wet particle: manufactured particle is dry with FG-3 boiling drier, and drying temperature is 50-60 DEG C, after dry
Survey particle angle of repose < 40 °, loss on drying 2%-4%；
Whole grain: by particle 20 mesh and 80 mesh sieves of moisture content qualification after drying, taking cannot by 20 meshes
Particle by 80 meshes is spare；
Disintegrating agent and wetting agent is added: weighing 1-3 parts of talcum powder, 0.1-0.3 parts of magnesium stearate, it is complete to be added into whole grain
Particle is uniformly mixed.
Further, the tabletting in the step S5:
Pressure testing: first with particle pressure testing on ZP19 rotary tablet machine uniformly mixed on a small quantity, adjusting pressure and loading,
Until slice weight is 1.5g or 2.5g；
Tabletting: installing hopper, puts dry particl into hopper, booting carries out tabletting；
Sieving: the piece pressed is weeded out into fine powder, puts into hermetic bag.
Further, it if the raw material in step S2 is more coarse, needs to first pass through pulverizer and carries out pulverization process.
Further, in the softwood processed, the raw material of addition is with moist.
One kind proposed by the present invention can effective calcium-supplement but also promote cell development calcium tablet preparation method, beneficial effect
It is: is divided into two kinds by the calcium tablet that the present invention produces, a kind of suitable children are edible, and another kind is suitble to designed for old people, children
When growing up, the phenomenon that often will appear calcium deficiency, the elderly is due to older, the phenomenon that being easy to appear osteoporosis, because
And the present invention produces corresponding calcium tablet for children and the elderly, relative to traditional calcium tablet in the market, is more easier to inhale
It receives, and effect of supplemented calcium is more preferably, meanwhile, this kind of calcium tablet also has the effect of promoting cell development, is beneficial to the health of people.
Detailed description of the invention
Fig. 1 be one kind of the present invention can effective calcium-supplement but also promote cell development calcium tablet preparation method flow chart.
Specific embodiment
Below in conjunction with embodiment, further description of the specific embodiments of the present invention, and following embodiment is only used for more
Add and clearly demonstrate technical solution of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
It is a kind of can effective calcium-supplement but also the calcium tablet for promoting cell development preparation method, include the following steps:
S1, raw material is into purchase: raw material includes calcium citrate, vitamine D3, milk powder, linseed meal, dextrin, magnesium stearate and sweet tea
Taste agent, raw material is into after purchase, then cooperates into purchase auxiliary material, and auxiliary material includes starch；
S2 is examined: the raw material in step S1 being sieved with 100 mesh sieve screening, the comparatively fine raw material of particle is filtered out and gives over to
It is spare, cold water 20ml is first added in starch and stirs evenly, then plus about 200ml hot water side trimming stirring, then with 100 meshes
Filtering；
S3 is weighed: the supplementary material in step S2 is weighed to the amount of needs according to the proportion；
S4, mixing granulation and drying: by the supplementary material in step S3 by softwood processed, wet granular processed, dry wet particle, whole
Grain, the process processing that disintegrating agent, wetting agent is added；
S5, tabletting: by the mixture in step S4 by pressure testing, tabletting, sieving process processing；
S6, chip select are simultaneously packed: the tabletting in step S5 being handled by chip select, selects the tabletting for reaching standard, then
Carry out packing processes.
Raw material proportioning in step S3 are as follows: 60 parts of calcium citrate, 0.00027 part of vitamine D3,10 parts of milk powder, linseed meal
3.5 parts, 13.5 parts of dextrin, 0.19973 part of magnesium stearate, 12.8 parts of sweetener.
Sweetener is white sugar, and the starch supplementary material of addition is 0.8 part, the children's calcium tablet being fabricated to every weight 1500mg.
Step S4:
Softwood processed: by load weighted calcium citrate, vitamine D3, milk powder, linolenic acid powder, sweetener, dextrin are put into CH-10
Several minutes are stirred in mixing machine after mixing, is slowly added into starch slurry stirring, until the suitable softwood of humidity viscosity is made；
Wet granular processed: the softwood made is squeezed into particle from stainless steel mesh with YK-60 oscillating granulator；
Dry wet particle: manufactured particle is dry with FG-3 boiling drier, and drying temperature is 60 DEG C, survey after drying
Grain angle of repose < 40 °, loss on drying 3%；
Whole grain: by particle 20 mesh and 80 mesh sieves of moisture content qualification after drying, taking cannot by 20 meshes
Particle by 80 meshes is spare；
Disintegrating agent and wetting agent is added: weighing 2 parts of talcum powder, 0.19973 part of magnesium stearate, is added into complete of whole grain
Grain is uniformly mixed.
Tabletting in step S5:
Pressure testing: first with particle pressure testing on ZP19 rotary tablet machine uniformly mixed on a small quantity, adjusting pressure and loading,
Until slice weight is 1.5g or 2.5g；
Tabletting: installing hopper, puts dry particl into hopper, booting carries out tabletting；
Sieving: the piece pressed is weeded out into fine powder, puts into hermetic bag.
If the raw material in step S2 is more coarse, needs to first pass through pulverizer and carry out pulverization process.
In softwood processed, the raw material of addition is with moist.
Embodiment 2
It is a kind of can effective calcium-supplement but also the calcium tablet for promoting cell development preparation method, include the following steps:
S1, raw material is into purchase: raw material includes calcium citrate, vitamine D3, milk powder, linseed meal, dextrin, magnesium stearate and sweet tea
Taste agent, raw material is into after purchase, then cooperates into purchase auxiliary material, and auxiliary material includes starch；
S2 is examined: the raw material in step S1 being sieved with 100 mesh sieve screening, the comparatively fine raw material of particle is filtered out and gives over to
It is spare, cold water 20ml is first added in starch and stirs evenly, then plus about 200ml hot water side trimming stirring, then with 100 meshes
Filtering；
S3 is weighed: the supplementary material in step S2 is weighed to the amount of needs according to the proportion；
S4, mixing granulation and drying: by the supplementary material in step S3 by softwood processed, wet granular processed, dry wet particle, whole
Grain, the process processing that disintegrating agent, wetting agent is added；
S5, tabletting: by the mixture in step S4 by pressure testing, tabletting, sieving process processing；
S6, chip select are simultaneously packed: the tabletting in step S5 being handled by chip select, selects the tabletting for reaching standard, then
Carry out packing processes.
Raw material proportioning in step S3 are as follows: 60 parts of calcium citrate, 0.00027 part of vitamine D3,10 parts of milk powder, linseed meal
3.5 parts, 13.5 parts of dextrin, 0.19973 part of magnesium stearate, 12.8 parts of sweetener.
Sweetener is xylitol, and the starch supplementary material of addition is 0.8 part, old calcium tablet every weight 2500mg being fabricated to.
Step S4:
Softwood processed: by load weighted calcium citrate, vitamine D3, milk powder, linolenic acid powder, sweetener, dextrin are put into CH-10
Several minutes are stirred in mixing machine after mixing, is slowly added into starch slurry stirring, until the suitable softwood of humidity viscosity is made；
Wet granular processed: the softwood made is squeezed into particle from stainless steel mesh with YK-60 oscillating granulator；
Dry wet particle: manufactured particle is dry with FG-3 boiling drier, and drying temperature is 60 DEG C, survey after drying
Grain angle of repose < 40 °, loss on drying 3%；
Whole grain: by particle 20 mesh and 80 mesh sieves of moisture content qualification after drying, taking cannot by 20 meshes
Particle by 80 meshes is spare；
Disintegrating agent and wetting agent is added: weighing 2 parts of talcum powder, 0.19973 part of magnesium stearate, is added into complete of whole grain
Grain is uniformly mixed.
Tabletting in step S5:
Pressure testing: first with particle pressure testing on ZP19 rotary tablet machine uniformly mixed on a small quantity, adjusting pressure and loading,
Until slice weight is 1.5g or 2.5g；
Tabletting: installing hopper, puts dry particl into hopper, booting carries out tabletting；
Sieving: the piece pressed is weeded out into fine powder, puts into hermetic bag.
If the raw material in step S2 is more coarse, needs to first pass through pulverizer and carry out pulverization process.
In softwood processed, the raw material of addition is with moist.
Experimental example: choosing the small white mouse young rat 30 just given a birth and be only divided into three groups, and every group is 10, and every group of code name point
Not Wei A group, B group, C group, then choose 2 years small white mouses 30 of growth and be only divided into three groups, every group 10, every group of code name is respectively D
Group, E group, F group, wherein to the calcium tablet obtained of small white mouse feeding embodiment 1 of A group, B group, to the small white mouse feeding market of C group
On common calcium tablet, to the calcium tablet obtained of small white mouse feeding embodiment 2 of D group, E group, and in the market to F group small white mouse feeding
Common calcium tablet, and after continuing 30 days, the DHA in bone density and blood to small white mouse is detected respectively.
Table 1: clinical detection result
The experimental results showed that the small white mouse being just born is after the calcium tablet in the edible embodiment of the present invention 1, what is lasted a long time is small
White mouse is after the calcium tablet in the edible embodiment of the present invention 2, the little Bai of the bone density data of bone compared to edible traditional calcium tablet
The content of the bone density of mouse is higher；And the content of DHA obtains in the blood of the small white mouse after the calcium tablet in the edible present invention
Raising is higher, and then can promote the development of small white mouse cell, since the mankind and small white mouse belong to mammal, after childbirth
Calcium tablet in the edible present invention of infant and the elderly when, replenishing the calcium and promoting itself for infant and the elderly can be promoted
The development of cell, and then be conducive to the health of infant and the elderly.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (7)
1. one kind can effective calcium-supplement but also promote cell development calcium tablet preparation method, which is characterized in that including walking as follows
It is rapid:
S1, raw material is into purchase: raw material includes calcium citrate, vitamine D3, milk powder, linseed meal, dextrin, magnesium stearate and sweet taste
Agent, raw material is into after purchase, then cooperates into purchase auxiliary material, and auxiliary material includes starch；
S2, examine: the raw material in step S1 is sieved with 100 mesh sieve into screening, filter out the comparatively fine raw material of particle give over to it is spare,
Cold water 20ml is first added in starch to stir evenly, then plus about 200ml hot water side trimming stirring, then with 100 mesh screens；
S3 is weighed: the supplementary material in step S2 is weighed to the amount of needs according to the proportion；
S4, mixing granulation and drying: by step S3 supplementary material by softwood processed, wet granular processed, dry wet particle, whole grain,
The process processing of disintegrating agent, wetting agent is added；
S5, tabletting: by the mixture in step S4 by pressure testing, tabletting, sieving process processing；
S6, chip select are simultaneously packed: the tabletting in step S5 being handled by chip select, the tabletting for reaching standard is selected, then carries out
Packing processes.
2. one kind according to claim 1 can effective calcium-supplement but also promote cell development calcium tablet preparation method,
It is characterized in that, raw material proportioning described in step S3 are as follows: 55-75 parts of calcium citrate, 0.0002-0.0003 parts of vitamine D3, cream
8-12 parts of powder, 2-5 parts of linseed meal, 12-15 parts of dextrin, 0.1-0.3 parts of magnesium stearate, 12-14 parts of sweetener.
3. one kind according to claim 1 can effective calcium-supplement but also promote cell development calcium tablet preparation method,
It is characterized in that, the sweetener is one of white sugar and xylitol, and the starch supplementary material of addition is 0.5-2 parts.
4. one kind according to claim 1 can effective calcium-supplement but also promote cell development calcium tablet preparation method,
It is characterized in that, the step S4:
Softwood processed: by load weighted calcium citrate, vitamine D3, milk powder, linolenic acid powder, sweetener, dextrin are put into CH-10 mixing
Several minutes are stirred in machine after mixing, is slowly added into starch slurry stirring, until the suitable softwood of humidity viscosity is made；
Wet granular processed: the softwood made is squeezed into particle from stainless steel mesh with YK-60 oscillating granulator；
Dry wet particle: manufactured particle is dry with FG-3 boiling drier, and drying temperature is 50-60 DEG C, survey after drying
Grain angle of repose < 40 °, loss on drying 2%-4%；
Whole grain: by particle 20 mesh and 80 mesh sieves of moisture content qualification after drying, taking cannot be passed through by 20 meshes
The particle of 80 meshes is spare；
Disintegrating agent and wetting agent is added: weighing 1-3 parts of talcum powder, 0.1-0.3 parts of magnesium stearate, is added into complete of whole grain
Grain is uniformly mixed.
5. one kind according to claim 1 can effective calcium-supplement but also promote cell development calcium tablet preparation method,
It is characterized in that, the tabletting in the step S5:
Pressure testing: first with particle pressure testing on ZP19 rotary tablet machine uniformly mixed on a small quantity, adjusting pressure and loading, until
Slice weight is 1.5g or 2.5g；
Tabletting: installing hopper, puts dry particl into hopper, booting carries out tabletting；
Sieving: the piece pressed is weeded out into fine powder, puts into hermetic bag.
6. one kind according to claim 1 can effective calcium-supplement but also promote cell development calcium tablet preparation method,
It is characterized in that, if the raw material in step S2 is more coarse, needs to first pass through pulverizer and carry out pulverization process.
7. one kind according to claim 4 can effective calcium-supplement but also promote cell development calcium tablet preparation method,
It is characterized in that, in the softwood processed, the raw material of addition is with moist.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110200931A (en) * | 2019-07-03 | 2019-09-06 | 宣城柏维力生物工程有限公司 | A kind of calcium vitamin D chewable tablets |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200931A (en) * | 2019-07-03 | 2019-09-06 | 宣城柏维力生物工程有限公司 | A kind of calcium vitamin D chewable tablets |
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Application publication date: 20190419 |