CN107320487A - A kind of ferrous bisglycinate chelate iron-supplementing preparation and preparation method thereof - Google Patents
A kind of ferrous bisglycinate chelate iron-supplementing preparation and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to field of medicine preparing technology, a kind of ferrous bisglycinate chelate iron-supplementing preparation and preparation method thereof is disclosed.Iron-supplementing preparation of the present invention includes ferrous bisglycinate chelate, vitamin C, jujube powder, Fruit powder, maltodextrin, white granulated sugar, glucose, citric acid, steviol glycoside and cyclodextrin, or ferrous bisglycinate chelate, vitamin C, jujube powder, Fruit powder, maltodextrin, white granulated sugar, glucose, citric acid, steviol glycoside and gelatin.Based on inclusion of the present invention by cyclodextrin or gelatin to ferrous bisglycinate chelate, add a variety of suitable components, prepare a kind of new ferrous bisglycinate chelate iron-supplementing preparation, iron taste can not only be covered and the stimulation to stomach is avoided, and benefit iron effect most can also be unexpectedly significantly improved, Patients with iron deficiency anemia is returned to normal hemoglobin level with less usage amount and shorter time.
Description
Technical field
The present invention relates to field of medicine preparing technology, and in particular to a kind of ferrous bisglycinate chelate iron-supplementing preparation and its preparation side
Method.
Background technology
Iron is one of important element of human body composition, and hypoferric anemia is common disease, according to reports indicate that, and the whole nation there are about
20% Genus Homo becomes the height of hypoferric anemia in different degrees of hypoferric anemia, particularly pregnant woman, children and the elderly
Send out colony.Iron-supplementing preparation species is various, and from inorganic iron, Organic Iron to biological iron supplementary, amino acid chelated iron, iron-supplementing preparation is continuous
Development.And almost all of iron-supplementing preparation, all exist that palatability is poor, there is larger iron taste, it is big to GI irritation, easily
Produce vomiting, heartburn, constipation and just black.Turn into the mark post that iron particle agent is mended in measurement therefore, it is possible to solve these problems.
Patent CN101129351A discloses a kind of iron supplementary composition, and it is by ferrous bisglycinate chelate, antioxidant and medicinal
Carrier is prepared from, although the iron supplementary as the patent is by compositional selecting and process optimization is to composition more palatable and mends iron effect
Fruit is improved, but its effect for mending iron is still barely satisfactory, it is necessary to further lifting, and iron taste covers effect
Difference.
The content of the invention
In view of this, it is an object of the invention to provide a kind of ferrous bisglycinate chelate iron-supplementing preparation and preparation method thereof so that
The iron-supplementing preparation can significantly improve benefit iron effect, and cover iron taste, not stimulating intestine and stomach.
To achieve these goals, the present invention provides following technical scheme：
A kind of ferrous bisglycinate chelate iron-supplementing preparation, including ferrous bisglycinate chelate, vitamin C, jujube powder, Fruit powder, maltodextrin,
White granulated sugar, glucose, citric acid, steviol glycoside and cyclodextrin；Or including ferrous bisglycinate chelate, vitamin C, jujube powder, fruit
Powder, maltodextrin, white granulated sugar, glucose, citric acid, steviol glycoside and gelatin.
For existing ferrous bisglycinate chelate iron supplementary effect it is poor the problem of, the present invention by cyclodextrin or gelatin to glycine
Ferrous iron is included, while being aided with other appropriate materials, can preferably cover iron taste, it is to avoid the stimulation to stomach, more
Surprisingly significantly improve benefit iron effect.
Wherein, preferably, in parts by weight, including 0.04~1.5 part of ferrous bisglycinate chelate, 0.1~2 part of vitamin C,
0.5~15 part of cyclodextrin or gelatin, 0.1~5 part of jujube powder, 1~30 fruits powder, 1~20 portion of maltodextrin, 1~50 part it is white
Granulated sugar, 1~50 part of glucose, 0.1~5 part of citric acid and 0.01~0.1 part of steviol glycoside.
In the embodiment of the present invention, the iron-supplementing preparation can be with specifically chosen following raw material (this hair
Bright parts by weight can be converted into any unit of weight, such as g, kg, kilogram, jin)：
(1) white granulated sugar 47.5g, glucose 23g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 0.1g, alpha-cyclodextrin 0.9g, steviol glycoside 0.1g；
(2) white granulated sugar 47.5g, glucose 21.3g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 0.2g, alpha-cyclodextrin 2.5g, steviol glycoside 0.1g；
(3) white granulated sugar 47.5g, glucose 23g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 0.1g, beta-schardinger dextrin 0.9g, steviol glycoside 0.1g；
(4) white granulated sugar 47.5g, glucose 21.3g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 0.2g, beta-schardinger dextrin 2.5g, steviol glycoside 0.1g；
(5) white granulated sugar 47.5g, glucose 22.4g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 0.1g, gamma-cyclodextrin 1.5g, steviol glycoside 0.1g；
(6) white granulated sugar 47.5g, glucose 21.3g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 0.2g, gamma-cyclodextrin 2.5g, steviol glycoside 0.1g；
(7) white granulated sugar 47.5g, glucose 7.5g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 1.5g, alpha-cyclodextrin 15g, steviol glycoside 0.1g；
(8) white granulated sugar 47.5g, glucose 7.5g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 1.5g, beta-schardinger dextrin 15g, steviol glycoside 0.1g；
(9) white granulated sugar 47.5g, glucose 7.5g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g,
Citric acid 5g, ferrous bisglycinate chelate 1.5g, gamma-cyclodextrin 15g, steviol glycoside 0.1g；
(10) white granulated sugar 47.5g, glucose 23.3g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder
5g, citric acid 5g, ferrous bisglycinate chelate 0.1g, edible gelatin 0.6g, steviol glycoside 0.1g；
(11) white granulated sugar 47.5g, glucose 12.5g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder
5g, citric acid 5g, ferrous bisglycinate chelate 1.5g, edible gelatin 10g, steviol glycoside 0.1g；
Preferably, the jujube powder is jujube, the filtrate after decocting mashing filtering or decocting directly filtering is spray-dried institute
；The former can add appropriate maltodextrin according to actual conditions and is spray-dried.
Preferably, the Fruit powder is sweet orange fruit powder, apple powder, mango fruit powder, orange fruit powder, lemon fruit powder, grape
It is more than one or both of fruit powder.
Preferably, the cyclodextrin is alpha-cyclodextrin, beta-schardinger dextrin or gamma-cyclodextrin.
Meanwhile, the invention provides the preparation method of the iron-supplementing preparation, including：
Step 1, using polishing or dissolve method by cyclodextrin encapsulated ferrous bisglycinate chelate, or by wall material of gelatin, it is sweet
Propylhomoserin ferrous iron is embedded for core, obtains ferrous bisglycinate chelate inclusion compound；
Step 2, by ferrous bisglycinate chelate inclusion compound and vitamin C, jujube powder, Fruit powder, maltodextrin, white granulated sugar, grape
Sugar, citric acid and steviol glycoside mixed pelletization, obtain iron-supplementing preparation.
Wherein, said preparation form can be granule, microcapsule formulations etc..
In the specific embodiment of the invention, the polishing is specific as follows：
Cyclodextrin and ferrous bisglycinate chelate are added in ball mill, the mill ball of stainless steel is added, ground 2 hours.
It is described that to dissolve method specific as follows：
Cyclodextrin, purified water, ferrous bisglycinate chelate are heated to reflux 60 minutes, less than 4 DEG C, suction filtration, precipitation are then cooled to
It washed once, dried after draining with water or 95% ethanol.
Pelletized preferably, the granulation crosses screen cloth by boiling granulating or softwood processed.
Iron-supplementing preparation of the present invention and some reference products are contrasted, as a result shown, before usage amount is suitable
Put, iron-supplementing preparation of the present invention can recover the hemoglobin of Patients with iron deficiency anemia to normal water within the shortest time
Flat, this shows, under identical recovery number of days, the iron content needed for iron-supplementing preparation of the present invention is minimum.Meanwhile, in each set product,
Product of the present invention covers the best results of iron taste, does not have any stimulation to stomach.
Based on above technical scheme, inclusion of the present invention by cyclodextrin or gelatin to ferrous bisglycinate chelate, add
A variety of suitable components, prepare a kind of new ferrous bisglycinate chelate iron-supplementing preparation, can not only cover iron taste and avoid pair
The stimulation of stomach, and benefit iron effect most can also be unexpectedly significantly improved, made with less usage amount and shorter time
Patients with iron deficiency anemia returns to normal hemoglobin level.
Embodiment
The invention discloses a kind of ferrous bisglycinate chelate iron-supplementing preparation and preparation method thereof, those skilled in the art can use for reference
Present disclosure, is suitably modified technological parameter realization.In particular, all similar replacements and change are to this area skill
It is it will be apparent that they are considered as being included in the present invention for art personnel.Product of the present invention and preparation method are
It is described by preferred embodiment, related personnel substantially can be not departing from present invention, in spirit and scope to herein
Described isolation and purification method is modified or suitably change is with combining, to realize and apply the technology of the present invention.
Just a kind of ferrous bisglycinate chelate iron-supplementing preparation provided by the present invention and preparation method thereof is described further below.
Embodiment 1：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
0.9g alpha-cyclodextrin and 0.1g ferrous bisglycinate chelate are added in ball mill, the mill ball of stainless steel is added, opens
It is ball mill operation to open power supply, and grinding obtains ferrous bisglycinate chelate inclusion compound after 2 hours.
By white granulated sugar 47.5g, glucose 23g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g are (big
Jujube is spray-dried gained after decocting mashing filtering), citric acid 5g, steviol glycoside 0.1g and above-mentioned inclusion compound add mixer
In be well mixed, suitable quantity of water is sprayed into after being seethed with excitement with fluid bed granulator as adhesive boiling granulating, 60 DEG C dry 90 minutes, to water
It is divided into less than 2%, discharging produces iron-supplementing preparation.
Embodiment 2：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
By 2.5g beta-schardinger dextrin, 3g purified waters, 0.2g ferrous bisglycinate chelates are added in round-bottomed flask, are heated to reflux (returning
Stream temperature is the boiling point of water, i.e., 100 DEG C) 60 minutes, it is poured into beaker, places in refrigerator and be cooled to less than 4 DEG C, taken out with bottle,suction
Filter, be washed once with water or 95% ethanol, and (drying temperature is controlled between 40~70 temperature, pellet moisture control for drying after draining
System is between 0.5~3.0%), obtain ferrous bisglycinate chelate inclusion compound.
By white granulated sugar 47.5g, glucose 21.3g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g
(jujube is spray-dried gained after decoction filtering), citric acid 5g, steviol glycoside 0.1g and above-mentioned inclusion compound add groove profile and mixed
In conjunction machine, appropriate 95% ethanol being added as adhesive softwood being made, pelletized with 14 eye mesh screens, 65 DEG C dry 2 hours, to moisture
Less than 3%, 14 mesh whole grains produce iron-supplementing preparation.
Embodiment 3：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
0.9g beta-schardinger dextrin and 0.1g ferrous bisglycinate chelate are added in ball mill, the mill ball of stainless steel is added, opens
It is ball mill operation to open power supply, and grinding obtains ferrous bisglycinate chelate inclusion compound after 2 hours.
By white granulated sugar 47.5g, glucose 23g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g are (big
Jujube is spray-dried gained after decocting mashing filtering), citric acid 5g, steviol glycoside 0.1g and above-mentioned inclusion compound add mixer
In be well mixed, suitable quantity of water is sprayed into after being seethed with excitement with fluid bed granulator as adhesive boiling granulating, 60 DEG C dry 90 minutes, to water
It is divided into less than 2%, discharging produces iron-supplementing preparation.
Embodiment 4：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
By 2.5g beta-schardinger dextrin, 3g purified waters, 0.2g ferrous bisglycinate chelates are added in round-bottomed flask, are heated to reflux (returning
Stream temperature is the boiling point of water, i.e., 100 DEG C) 60 minutes, it is poured into beaker, places in refrigerator and be cooled to less than 4 DEG C, taken out with bottle,suction
Filter, be washed once with water or 95% ethanol, and (drying temperature is controlled between 40~70 temperature, pellet moisture control for drying after draining
System is between 0.5~3.0%), obtain ferrous bisglycinate chelate inclusion compound.
By white granulated sugar 47.5g, glucose 21.3g, maltodextrin 6g, sweet orange powder 12g, vitamin C 0.4g, jujube powder 5g
(jujube is spray-dried gained after decoction filtering), citric acid 5g, steviol glycoside 0.1g and above-mentioned inclusion compound add groove profile and mixed
In conjunction machine, appropriate 95% ethanol being added as adhesive softwood being made, pelletized with 14 eye mesh screens, 65 DEG C dry 2 hours, to moisture
Less than 3%, 14 mesh whole grains produce iron-supplementing preparation.
Embodiment 5：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
1.5g gamma-cyclodextrin and 0.1g ferrous bisglycinate chelate are added in ball mill, the mill ball of stainless steel is added, opens
It is ball mill operation to open power supply, and grinding obtains ferrous bisglycinate chelate inclusion compound after 2 hours.
By 47.5g white granulated sugars, 22.4g glucose, 12g sweet oranges powder, 6g maltodextrins, 0.4g vitamin Cs, 5g citric acids,
5g jujube powders (jujube is spray-dried gained after decocting mashing filtering), 0.1g steviol glycosides and above-mentioned inclusion compound are added and mixed
It is well mixed in machine, suitable quantity of water is sprayed into after being seethed with excitement with fluid bed granulator as adhesive boiling granulating, 60 DEG C dries 90 minutes, extremely
Moisture is less than 2%, and discharging produces iron-supplementing preparation.
Embodiment 6：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
By 2.5g gamma-cyclodextrin, 3g parts of purified waters, 0.2g ferrous bisglycinate chelates are added in round-bottomed flask, are heated to reflux
(reflux temperature is the boiling point of water, i.e., 100 DEG C) 60 minutes, is poured into beaker, places in refrigerator and is cooled to less than 4 DEG C, uses suction filtration
Bottle suction filtration, be washed once with water or 95% ethanol, and (drying temperature is controlled between 40~70 temperature, particle water for drying after draining
Sub-control system is between 0.5~3.0%), obtain ferrous bisglycinate chelate inclusion compound.
By 47.5g white granulated sugars, 21.3g glucose, 12 sweet orange powder, 6g maltodextrins, 0.4g vitamin Cs, 5g citric acids, 5g
Jujube powder (jujube is spray-dried gained after decoction filtering), 0.1g steviol glycosides and above-mentioned inclusion compound add trough type mixing machine
In, appropriate 95% ethanol being added as adhesive softwood being made, pelletized with 14 eye mesh screens, 65 DEG C dry 2 hours, to moisture 3%
Hereinafter, 14 mesh whole grain, produces iron-supplementing preparation.
Embodiment 7：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
15g alpha-cyclodextrin and 1.5g ferrous bisglycinate chelate are added in ball mill, the mill ball of stainless steel is added, opened
Power supply is ball mill operation, and grinding obtains ferrous bisglycinate chelate inclusion compound after 2 hours.
By 47.5g white granulated sugars, 7.5g glucose, 12g sweet oranges powder, 6g maltodextrins, 0.4g vitamin Cs, 5g citric acids, 5g
Jujube powder (jujube is spray-dried gained after decocting mashing filtering), 0.1g steviol glycosides and above-mentioned inclusion compound add mixer
In be well mixed, suitable quantity of water is sprayed into after being seethed with excitement with fluid bed granulator as adhesive boiling granulating, 60 DEG C dry 90 minutes, to water
It is divided into less than 2%, discharging produces iron-supplementing preparation.
Embodiment 8：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
15g beta-schardinger dextrin and 1.5g ferrous bisglycinate chelate are added in ball mill, the mill ball of stainless steel is added, opened
Power supply is ball mill operation, and grinding obtains ferrous bisglycinate chelate inclusion compound after 2 hours.
By 47.5g white granulated sugars, 7.5g glucose, 12g sweet oranges powder, 6g maltodextrins, 0.4g vitamin Cs, 5g citric acids, 5g
Jujube powder (jujube is spray-dried gained after decocting mashing filtering), 0.1g steviol glycosides and above-mentioned inclusion compound add mixer
In be well mixed, suitable quantity of water is sprayed into after being seethed with excitement with fluid bed granulator as adhesive boiling granulating, 60 DEG C dry 90 minutes, to water
It is divided into less than 2%, discharging produces iron-supplementing preparation.
Embodiment 9：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
15g gamma-cyclodextrin and 1.5g ferrous bisglycinate chelate are added in ball mill, the mill ball of stainless steel is added, opens
It is ball mill operation to open power supply, and grinding obtains ferrous bisglycinate chelate inclusion compound after 2 hours.
By 47.5g white granulated sugars, 7.5g glucose, 12g sweet oranges powder, 6g maltodextrins, 0.4g vitamin Cs, 5g citric acids, 5g
Jujube powder (jujube is spray-dried gained after decocting mashing filtering), 0.1g steviol glycosides and above-mentioned inclusion compound add mixer
In be well mixed, suitable quantity of water is sprayed into after being seethed with excitement with fluid bed granulator as adhesive boiling granulating, 60 DEG C dry 90 minutes, to water
It is divided into less than 2%, discharging produces iron-supplementing preparation.
Embodiment 10：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
Gelatin is configured to 6% aqueous gelatin solution (i.e. 0.6g gelatin adds 9.4g water), 6% aqueous gelatin solution and 0.1g
Ferrous bisglycinate chelate is well mixed, and EAT is 170 DEG C, and feed rate is that 4mL/min is spray-dried, and obtains glycine sub-
Iron inclusion compound.
By 47.5g white granulated sugars, 23.3g glucose, 12g sweet oranges powder, 6g maltodextrins, 0.4g vitamin Cs, 5g citric acids,
5g jujube powders (jujube is spray-dried gained after decocting mashing filtering), 0.1gg steviol glycosides and above-mentioned inclusion compound add mixed
It is well mixed in conjunction machine, suitable quantity of water is sprayed into after being seethed with excitement with fluid bed granulator as adhesive boiling granulating, 60 DEG C dry 90 minutes,
It is less than 2% to moisture, discharging produces iron-supplementing preparation.
Embodiment 11：Prepare ferrous bisglycinate chelate iron-supplementing preparation of the present invention
Gelatin is configured to 10% aqueous gelatin solution (i.e. 10g gelatin adds 90g water), 10% aqueous gelatin solution and 1.5g
Ferrous bisglycinate chelate is well mixed, and EAT is 170 DEG C, and feed rate is that 4mL/min is spray-dried, and obtains glycine sub-
Iron inclusion compound.
By 47.5g white granulated sugars, 12.5g glucose, 12g sweet oranges powder, 6g maltodextrins, 0.4g vitamin Cs, 5g citric acids,
5g jujube powders (jujube is spray-dried gained after decocting mashing filtering), 0.1g steviol glycosides and above-mentioned inclusion compound are added and mixed
It is well mixed in machine, suitable quantity of water is sprayed into after being seethed with excitement with fluid bed granulator as adhesive boiling granulating, 60 DEG C dries 90 minutes, extremely
Moisture is less than 2%, and discharging produces iron-supplementing preparation.
Embodiment 12：Iron-supplementing preparation mends iron Piglet s colibacillosis
1st, control group
(1) with reference to the preparation method of embodiment 1, without using cyclodextrin and gelatin, directly by ferrous bisglycinate chelate and other each groups
Divide granulation；
(2) with reference to the preparation method of embodiment 1, directly the granulation of ferrous bisglycinate chelate, cyclodextrin and other each components (is not wrapped
Close)；
(3) prepared with reference to the preparation method of embodiment 1 in product, component and delete jujube powder；
(4) with reference to the preparation method of embodiment 1, directly the granulation of ferrous bisglycinate chelate, cyclodextrin and other each components (is not wrapped
Close), while deleting jujube powder in component；
(5) with reference to the preparation method of embodiment 10, directly the granulation of ferrous bisglycinate chelate, gelatin and other each components (is not wrapped
Close)；
(6) prepared with reference to the preparation method of embodiment 10 in product, component and delete jujube powder；
(7) with reference to the preparation method of embodiment 10, directly the granulation of ferrous bisglycinate chelate, gelatin and other each components (is not wrapped
Close), while deleting jujube powder in component；
2nd, test group
Embodiment 1-8 products
3rd, test method
Reference literature《Ferrous lactate treats the clinical research of hypoferric anemia》(Li Xiaoming, Chen upstart etc., Luzhou medical science)
In materials and methods part carry out, adjusted in usage amount, every group of patient 10, the initial hemoglobin of each group patient is each other
Between do not possess significant difference, quite, hemoglobin recovers normal value number of days and taken the mean health.
4th, result of the test
Table 1
As seen from the above table, on the premise of usage amount is suitable, iron-supplementing preparation of the present invention can be incited somebody to action within the shortest time
The hemoglobin of Patients with iron deficiency anemia recovers to normal level, and this shows, under identical recovery number of days, iron-supplementing preparation of the present invention
Required iron content is minimum.Meanwhile, in each set product, product of the present invention covers the best results of iron taste, does not have to stomach
It is any to stimulate.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (9)
1. a kind of ferrous bisglycinate chelate iron-supplementing preparation, it is characterised in that including ferrous bisglycinate chelate, vitamin C, jujube powder, Fruit powder,
Maltodextrin, white granulated sugar, glucose, citric acid, steviol glycoside and cyclodextrin；Or including ferrous bisglycinate chelate, vitamin C, big
Date powder, Fruit powder, maltodextrin, white granulated sugar, glucose, citric acid, steviol glycoside and gelatin.
2. iron-supplementing preparation according to claim 1, it is characterised in that in parts by weight, including 0.04~1.5 part of glycine Asia
Iron, 0.1~2 part of vitamin C, 0.5~15 part of cyclodextrin or gelatin, 0.1~5 part of jujube powder, 1~30 fruits powder, 1~20 part
Maltodextrin, 1~50 portion of white granulated sugar, 1~50 part of glucose, 0.1~5 part of citric acid and 0.01~0.1 part of steviol glycoside.
3. iron-supplementing preparation according to claim 1 or claim 2, it is characterised in that the jujube powder is jujube through decocting mashing filtering
Or decoct filtrate spray drying gained after directly filtering.
4. iron-supplementing preparation according to claim 1 or claim 2, it is characterised in that the Fruit powder is sweet orange fruit powder, apple powder, awns
It is more than one or both of fruit fruit powder, orange fruit powder, lemon fruit powder, grape fruit powder.
5. iron-supplementing preparation according to claim 1 or claim 2, it is characterised in that the cyclodextrin be alpha-cyclodextrin, beta-schardinger dextrin or
Gamma-cyclodextrin.
6. the preparation method of iron-supplementing preparation described in claim 1, it is characterised in that including：
Step 1, using polishing or dissolve method by cyclodextrin encapsulated ferrous bisglycinate chelate, or by wall material of gelatin, glycine
Ferrous iron is embedded for core, obtains ferrous bisglycinate chelate inclusion compound；
Step 2, by ferrous bisglycinate chelate inclusion compound and vitamin C, jujube powder, Fruit powder, maltodextrin, white granulated sugar, glucose, lemon
Lemon acid and steviol glycoside mixed pelletization, obtain iron-supplementing preparation.
7. preparation method according to claim 6, it is characterised in that the polishing is specific as follows：
Cyclodextrin and ferrous bisglycinate chelate are added in ball mill, the mill ball of stainless steel is added, ground 2 hours.
8. preparation method according to claim 6, it is characterised in that dissolve method specific as follows：
Cyclodextrin, purified water, ferrous bisglycinate chelate are heated to reflux 60 minutes, less than 4 DEG C, suction filtration, precipitation water are then cooled to
Or 95% ethanol washed once, after draining dry.
9. preparation method according to claim 6, it is characterised in that the granulation crosses screen cloth by boiling granulating or softwood processed
Granulation.
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Cited By (5)
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| CN110464011A (en) * | 2018-08-07 | 2019-11-19 | 美安康质量检测技术（上海）有限公司 | One kind is enriched blood nutrient powder and preparation method thereof |
| CN112544976A (en) * | 2020-12-11 | 2021-03-26 | 海而思（郑州）科技有限公司 | Sugar-free iron-supplementing composition and preparation method thereof |
| CN114272337A (en) * | 2022-01-13 | 2022-04-05 | 开封嘉骏生物科技有限公司 | Traditional Chinese medicine preparation for improving animal anemia and preparation method |
| CN115463124A (en) * | 2022-11-02 | 2022-12-13 | 海而思（郑州）科技有限公司 | Iron-supplementing effervescent tablet and preparation method thereof |
| CN115918827A (en) * | 2022-08-30 | 2023-04-07 | 重庆喜旋生物科技有限公司 | Calcium acetate nutrition powder and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464011A (en) * | 2018-08-07 | 2019-11-19 | 美安康质量检测技术（上海）有限公司 | One kind is enriched blood nutrient powder and preparation method thereof |
| CN112544976A (en) * | 2020-12-11 | 2021-03-26 | 海而思（郑州）科技有限公司 | Sugar-free iron-supplementing composition and preparation method thereof |
| CN114272337A (en) * | 2022-01-13 | 2022-04-05 | 开封嘉骏生物科技有限公司 | Traditional Chinese medicine preparation for improving animal anemia and preparation method |
| CN115918827A (en) * | 2022-08-30 | 2023-04-07 | 重庆喜旋生物科技有限公司 | Calcium acetate nutrition powder and preparation method thereof |
| CN115463124A (en) * | 2022-11-02 | 2022-12-13 | 海而思（郑州）科技有限公司 | Iron-supplementing effervescent tablet and preparation method thereof |
| CN115463124B (en) * | 2022-11-02 | 2024-04-05 | 海而思（郑州）科技有限公司 | Iron supplementing effervescent tablet and preparation method thereof |
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| CN107320487B (en) | 2019-11-15 |
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