CN109640969A - 用于減少体重的皮下注射剂及其用途 - Google Patents
用于減少体重的皮下注射剂及其用途 Download PDFInfo
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- CN109640969A CN109640969A CN201780050055.5A CN201780050055A CN109640969A CN 109640969 A CN109640969 A CN 109640969A CN 201780050055 A CN201780050055 A CN 201780050055A CN 109640969 A CN109640969 A CN 109640969A
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- curcumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
Abstract
本发明提供一种用于减少体重的皮下注射剂,包含聚氧乙烯蓖麻油衍生物所形成的多个含药微胞、以及被包覆在所述含药微胞中的姜黄色素类物质。所述用于减少体重的皮下注射剂可减少过重或肥胖个体的体重及内脏脂肪,且具有剂量低、高稳定性、高度脂肪组织生物利用率、低副作用、以及缓释等优点。
Description
PCT国内申请,说明书已公开。
Claims (1)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2016/055102 WO2017037594A2 (zh) | 2015-08-28 | 2016-08-26 | 用于减少局部脂肪的医药组成物及其用途 |
IBPCT/IB2016/055102 | 2016-08-26 | ||
IBPCT/IB2016/055101 | 2016-08-26 | ||
PCT/IB2016/055101 WO2017037593A2 (zh) | 2015-08-28 | 2016-08-26 | 用于减少局部脂肪的医药组成物及其用途 |
PCT/IB2017/055129 WO2018037384A1 (zh) | 2016-08-26 | 2017-08-25 | 用于減少体重的皮下注射剂及其用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109640969A true CN109640969A (zh) | 2019-04-16 |
Family
ID=66641545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780050055.5A Pending CN109640969A (zh) | 2016-08-26 | 2017-08-25 | 用于減少体重的皮下注射剂及其用途 |
Country Status (6)
Country | Link |
---|---|
US (2) | US10716824B2 (zh) |
EP (1) | EP3505168A1 (zh) |
KR (1) | KR20190040305A (zh) |
CN (1) | CN109640969A (zh) |
CA (1) | CA3033041A1 (zh) |
WO (1) | WO2018037384A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016314546C1 (en) | 2015-08-28 | 2021-07-22 | Caliway Biopharmaceuticals Co., Ltd. | Pharmaceutical composition used for reducing localised fat and use of pharmaceutical composition |
US11318110B2 (en) | 2015-08-28 | 2022-05-03 | Caliway Biopharmaceuticals Co., Ltd. | Pharmaceutical composition for reducing local fat and uses thereof |
US20230372378A1 (en) * | 2022-05-16 | 2023-11-23 | Caliway Biopharmaceuticals Co., Ltd. | Compositions and methods for alleviating conditions caused by abnormal subcutaneous deposit of adipose tissue or fat |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6475530B1 (en) * | 2000-05-31 | 2002-11-05 | Eric H. Kuhrts | Methods and compositions for producing weight loss |
US20050267221A1 (en) * | 2004-05-14 | 2005-12-01 | Research Development Foundation | Use of curcumin and analogues thereof as inhibitors of ACC2 |
CN1895239A (zh) * | 2006-06-20 | 2007-01-17 | 中国人民解放军第二军医大学 | 一种姜黄素制剂及其制备方法 |
CN101310718A (zh) * | 2007-05-23 | 2008-11-26 | 中国科学院上海生命科学研究院 | 减肥降血脂的含儿茶素的组合物及其用途 |
US20090324703A1 (en) * | 2006-03-06 | 2009-12-31 | Frautschy Sally A | Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders |
CN103054807A (zh) * | 2011-12-22 | 2013-04-24 | 苏州雷纳药物研发有限公司 | 一种肌内或皮下注射用姜黄素微粉组合物及其制备方法和用途 |
CN103285401A (zh) * | 2013-05-27 | 2013-09-11 | 沈阳药科大学 | 一种能提高难溶性药物溶解性和生物利用度的组合物 |
WO2014138426A2 (en) * | 2013-03-07 | 2014-09-12 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
WO2015081319A2 (en) * | 2013-11-27 | 2015-06-04 | Research Foundation Of The City University Of New York | Activity enhancing curcumin compositions and methods of use |
WO2016029870A1 (zh) * | 2014-08-28 | 2016-03-03 | 康霈生技股份有限公司 | 用于减少局部脂肪与减少体重的组合物及其医药品与应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040071799A1 (en) | 2001-02-12 | 2004-04-15 | Xiurong Xu | Herbal compositions and methods for effecting weight loss in humans |
JP4179494B2 (ja) * | 2001-10-23 | 2008-11-12 | 株式会社カネカ | ペルオキシソーム増殖剤応答性受容体リガンド剤 |
US20060188590A1 (en) * | 2005-01-05 | 2006-08-24 | Mitsunori Ono | Compositions for treating diabetes or obesity |
US10226503B2 (en) | 2014-08-28 | 2019-03-12 | Caliway Biopharmaceuticals Co., Ltd. | Plant extract composition for reducing topical fat and promoting weight loss as well as applications thereof |
AU2016314546C1 (en) | 2015-08-28 | 2021-07-22 | Caliway Biopharmaceuticals Co., Ltd. | Pharmaceutical composition used for reducing localised fat and use of pharmaceutical composition |
-
2017
- 2017-08-25 CA CA3033041A patent/CA3033041A1/en not_active Abandoned
- 2017-08-25 US US16/327,466 patent/US10716824B2/en active Active
- 2017-08-25 CN CN201780050055.5A patent/CN109640969A/zh active Pending
- 2017-08-25 EP EP17843043.5A patent/EP3505168A1/en not_active Withdrawn
- 2017-08-25 WO PCT/IB2017/055129 patent/WO2018037384A1/zh unknown
- 2017-08-25 KR KR1020197008320A patent/KR20190040305A/ko active Search and Examination
-
2020
- 2020-07-10 US US16/926,631 patent/US20200338152A1/en not_active Abandoned
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6475530B1 (en) * | 2000-05-31 | 2002-11-05 | Eric H. Kuhrts | Methods and compositions for producing weight loss |
US20050267221A1 (en) * | 2004-05-14 | 2005-12-01 | Research Development Foundation | Use of curcumin and analogues thereof as inhibitors of ACC2 |
US20090324703A1 (en) * | 2006-03-06 | 2009-12-31 | Frautschy Sally A | Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders |
CN1895239A (zh) * | 2006-06-20 | 2007-01-17 | 中国人民解放军第二军医大学 | 一种姜黄素制剂及其制备方法 |
CN101310718A (zh) * | 2007-05-23 | 2008-11-26 | 中国科学院上海生命科学研究院 | 减肥降血脂的含儿茶素的组合物及其用途 |
CN103054807A (zh) * | 2011-12-22 | 2013-04-24 | 苏州雷纳药物研发有限公司 | 一种肌内或皮下注射用姜黄素微粉组合物及其制备方法和用途 |
WO2014138426A2 (en) * | 2013-03-07 | 2014-09-12 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
CN103285401A (zh) * | 2013-05-27 | 2013-09-11 | 沈阳药科大学 | 一种能提高难溶性药物溶解性和生物利用度的组合物 |
WO2015081319A2 (en) * | 2013-11-27 | 2015-06-04 | Research Foundation Of The City University Of New York | Activity enhancing curcumin compositions and methods of use |
WO2016029870A1 (zh) * | 2014-08-28 | 2016-03-03 | 康霈生技股份有限公司 | 用于减少局部脂肪与减少体重的组合物及其医药品与应用 |
Non-Patent Citations (2)
Title |
---|
HU ET AL: "Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System", 《AAPS PHARMSCITECH》 * |
KISS 等: "Kinetic Analysis of the Toxicity of Pharmaceutical Excipients Cremophor EL and RH40 on Endothelial and Epithelial Cells", 《RAPID COMMUNICATION》 * |
Also Published As
Publication number | Publication date |
---|---|
US10716824B2 (en) | 2020-07-21 |
WO2018037384A1 (zh) | 2018-03-01 |
US20200338152A1 (en) | 2020-10-29 |
EP3505168A1 (en) | 2019-07-03 |
US20190167753A1 (en) | 2019-06-06 |
KR20190040305A (ko) | 2019-04-17 |
CA3033041A1 (en) | 2018-03-01 |
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Legal Events
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190416 |