CN109621210A - A kind of figure-eight coil and its configuring management method for transcranial magnetic stimulation control experiment - Google Patents
A kind of figure-eight coil and its configuring management method for transcranial magnetic stimulation control experiment Download PDFInfo
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- CN109621210A CN109621210A CN201811631417.2A CN201811631417A CN109621210A CN 109621210 A CN109621210 A CN 109621210A CN 201811631417 A CN201811631417 A CN 201811631417A CN 109621210 A CN109621210 A CN 109621210A
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- 238000002474 experimental method Methods 0.000 title claims abstract description 28
- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 25
- 238000007726 management method Methods 0.000 title claims abstract description 7
- 239000000178 monomer Substances 0.000 claims abstract description 47
- 230000000638 stimulation Effects 0.000 claims abstract description 13
- 230000000694 effects Effects 0.000 abstract description 9
- 238000000034 method Methods 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000004146 energy storage Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000001178 neural stem cell Anatomy 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
Abstract
The present invention provides a kind of figure-eight coil for transcranial magnetic stimulation control experiment, it contains the first circular coil and the second circular coil, the counter-clockwise coiling of first circular coil, input terminal is A2, output end is A1, the second circular coil coiling clockwise, input terminal is B1, output end is B2, the input terminal and output end of two circular coil pass through 4 monomer switch K1, K2, K3, K4 connection combination, form the identical or opposite different configuration status of two circular coil point of intersection current directions, monomer switch K1, monomer switch K2, monomer switch K3, the switch state of monomer switch K4 is controlled by control module.The present invention also provides a kind of configuring management methods of figure-eight coil, and the switch state by controlling monomer switch K1, K2, K3, K4 configures the 8 wordline circle, freely realize normal stimulus or pseudo- stimulation.In control experiment double blind effect can be realized to operator and experimenter.
Description
Technical field
The invention belongs to transcranial magnetic stimulation technical field, in particular to a kind of 8 words for transcranial magnetic stimulation control experiment
Shape coil and its configuring management method.
Background technique
Transcranial magnetic stimulation (Transcranial magnetic stimulation, abbreviation TMS) technology is a kind of using arteries and veins
Magnetic fields are rushed in central nervous system, changes the film potential of cortical neural cell, is allowed to generate induced current, influence intracerebral generation
It thanks and neural electrical activity, so as to cause a series of Neural stem cell technology of biochemical reactions.TMS has noninvasive, painless, safe
Feature can be used for stimulating cranial nerve, nerve root and peripheral nerve.Be now widely used in Neuscience, brain science research field and
The diagnosing and treating of clinical disease.
It needs to do control experiment when judging transcranial magnetic stimulation system curative effect, in general, experiment total score is experimental group and right
According to group.Experimental group is the object group for receiving experimental variable processing；Control group, also referred to as control group are not for experimental hypothesis
Receive the object group of experimental variable processing, as which as experimental group, which is usually determined at random as a control group,
In this way, in theory, due to experimental group with the influence of the irrelevant variable of control group be it is equal, be balanced, therefore tested
The difference of group and both control groups, then can regard as being the effect from experimental variable, such experimental result is believable.And
Existing transcranial magnetic stimulation curative effect comparision experiment passes through the relative position for changing stimulating coil, for example figure-eight coil posture is changed
Become 90 degree to weaken coil to the stimulus intensity of experimental subjects.But double blind effect is not achieved in such control experiment.
Summary of the invention
The purpose of the present invention is to provide a kind of 8-shaped for transcranial magnetic stimulation control experiment of achievable double blind effect
Coil and its configuring management method.
To achieve the above object, the present invention adopts the following technical scheme:
A kind of figure-eight coil for transcranial magnetic stimulation control experiment, the figure-eight coil contain the first circular coil and
Second circular coil, the counter-clockwise coiling of the first circular coil, input terminal A2, output end A1, second round wire
Coiling clockwise, input terminal B1, output end B2 are enclosed, two circular coil is connected by 4 monomer switches K1, K2, K3, K4
Combination is connect, the anode of A2 and monomer switch K1, the anode of monomer switch K2 are electrically connected and as the figure-eight coil
First terminal P1, A1 are electrically connected and with the anode of monomer switch K3, the anode of monomer switch K4 as the 8-shaped line
The Second terminal P2, B1 of circle are electrically connected with the cathode of the cathode of monomer switch K2, monomer switch K3, and B2 and monomer switch K1's is negative
Pole, monomer switch K4 cathode be electrically connected, monomer switch K1, monomer switch K2, monomer switch K3, monomer switch K4
Switch state is controlled by control module.
Described monomer switch K1, K2, K3, the K4 is high-voltage relay.
The configuring management method of figure-eight coil for transcranial magnetic stimulation control experiment, includes the following steps:
(1) in control experiment, it is the determination state for carrying out normal stimulus or pseudo- stimulation that control module, which is obtained to experimenter,；
(2) to carry out normal stimulus to experimenter, described control module control K1, K3 are disconnected, K2, K4 closure, and described 8
It is identical in point of intersection current direction that font coil is configured to two circular coils, to experimenter's normal stimulus；
(3) to carry out pseudo- stimulation, control module control K1, K3 closure to experimenter, K2, K4 are disconnected, 8 word
Shape coil is configured to two circular coils in point of intersection current direction on the contrary, carrying out pseudo- stimulation to experimenter.
Compared with prior art, the invention has the following advantages that the present invention provides one kind for transcranial magnetic stimulation to according to the facts
The figure-eight coil tested, according to the corresponding state value of experimenter, control module controls the switch of monomer switch K1, K2, K3, K4
State configures the figure-eight coil, realizes normal stimulus or pseudo- stimulation.It can be to operator and reality during control experiment
The person of testing reaches double blind effect.
Detailed description of the invention
Fig. 1 is a kind of transcranial magnetic stimulation systematic schematic diagram；
Fig. 2 is the figure-eight coil system schematic for transcranial magnetic stimulation control experiment of the invention；
Fig. 3 is the pseudo- stimulation schematic diagram of figure-eight coil configuration for transcranial magnetic stimulation control experiment of the invention；
Fig. 4 is that the figure-eight coil for transcranial magnetic stimulation control experiment of the invention configures normal stimulus schematic diagram.
Specific embodiment
Below with reference to specification embodiment and Figure of description, invention is further explained.
A kind of transcranial magnetic stimulation system principle is provided herein, as shown in Figure 1, transcranial magnetic stimulation system generally will by power supply
Then energy storage allows energy storage pulsed capacitance to discharge coil rapid large-current in energy storage pulsed capacitance, generate momentary pulse
Magnetic field stimulates patient, and general stimulating coil mostly uses figure-eight coil, when figure-eight coil normal stimulus, coil intersection point
It is identical to locate current direction, to magnetic field maximum occur in two circular coil point of intersection, for stimulating patient.
Figure-eight coil basic principle for transcranial magnetic stimulation control experiment is as shown in Fig. 2, the figure-eight coil contains
First circular coil and the second circular coil, the counter-clockwise coiling of the first circular coil, input terminal A2, output end A1,
The second circular coil coiling clockwise, input terminal B1, output end B2, two circular coil are opened by 4 monomers
K1, K2, K3, K4 connection combination are closed, the anode of A2 and monomer switch K1, the anode of monomer switch K2 is electrically connected and conduct
The anode of the first terminal P1, A1 of the figure-eight coil and monomer switch K3, the anode of monomer switch K4 are electrically connected simultaneously
Second terminal P2, B1 as the figure-eight coil are electrically connected with the cathode of the cathode of monomer switch K2, monomer switch K3, B2
It is electrically connected with the cathode of monomer switch K1, the cathode of monomer switch K4, monomer switch K1, monomer switch K2, monomer are opened
Close K3, monomer switch K4 is realized that switch state is controlled by control module by high-voltage relay.
As shown in figure 3, K2, K4 are disconnected, then A1 connect with B1 short circuit and is electrically connected with P2, and A2 is short with B2 when K1, K3 are closed
Road, which connects, to be simultaneously electrically connected with P1, so that actually two circular coils are in the current direction of point of intersection on the contrary, to export experimenter
Puppet stimulation.
As shown in figure 4, K2, K4 closure, then A1 connect with B2 short circuit and is electrically connected with P2, and A2 is short with B1 when K1, K3 are disconnected
Road connects and is electrically connected with P1, so that practical two circular coils are identical in the current direction of point of intersection, so that exporting to experimenter
Normal stimulus.
Transcranial magnetic stimulation control experiment comprises the following processes: when starting control experiment, operator uses upper computer software pair
Experimenter carries out unique encodings, and upper computer software is that random generate of each experimenter coding carries out normal stimulus or pseudo- stimulation
State value, in experimentation, the state value described in the same experimenter is unique, but the state value is not to operator and experiment
Person discloses, and control module controls monomer switch K1, K2, K3, K4 and configure to the figure-eight coil according to the state value,
If necessary to carry out normal stimulus, then configuration status is K1, K3 disconnection, K2, K4 closure；It is then configured if necessary to carry out pseudo- stimulation
State is K1, K3 closure, and K2, K4 are disconnected, and realizes normal stimulus or pseudo- stimulation on demand, after experiment, with corresponding authority
Operator can read the state value that each experimenter is assigned by the upper computer software and right from the upper computer software system
The experimental data answered.Entire control experiment process can reach double blind effect to operator and experimenter.
The above is only the preferred embodiments of the disclosure, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, it is contemplated that change or replacement should all cover this
Within the protection scope of invention.
Claims (3)
1. a kind of figure-eight coil for transcranial magnetic stimulation control experiment, it is characterised in that the figure-eight coil contains the first circle
Shape coil and the second circular coil, the counter-clockwise coiling of the first circular coil, input terminal A2, output end A1, described
The coiling clockwise of two circular coils, input terminal B1, output end B2, two circular coil by 4 monomer switch K1,
The anode of K2, K3, K4 connection combination, A2 and monomer switch K1, the anode of monomer switch K2 are electrically connected and as described 8
The anode of the first terminal P1, A1 of font coil and monomer switch K3, the anode of monomer switch K4 is electrically connected and conduct
The Second terminal P2, B1 of the figure-eight coil are electrically connected with the cathode of the cathode of monomer switch K2, monomer switch K3, B2 and list
The cathode of body switch K1, the cathode of monomer switch K4 are electrically connected, monomer switch K1, monomer switch K2, monomer switch K3,
The switch state of monomer switch K4 is controlled by control module.
2. being used for the figure-eight coil of transcranial magnetic stimulation control experiment as described in claim 1, which is characterized in that the list
Body switch K1, K2, K3, K4 are high-voltage relay.
3. a kind of configuring management method of the figure-eight coil in transcranial magnetic stimulation control experiment, based on as described in claim 1
The figure-eight coil for transcranial magnetic stimulation control experiment, include the following steps:
(1) in control experiment, it is the determination state for carrying out normal stimulus or pseudo- stimulation that control module, which is obtained to experimenter,；
(2) to carry out normal stimulus to experimenter, described control module control K1, K3 are disconnected, K2, K4 closure, the 8-shaped
It is identical in point of intersection current direction that coil is configured to two circular coils, realizes to experimenter's normal stimulus；
(3) to carry out pseudo- stimulation, control module control K1, K3 closure to experimenter, K2, K4 are disconnected, the 8-shaped line
Circle is configured to two circular coils in point of intersection current direction and carries out pseudo- stimulation to experimenter on the contrary, realizing.
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| CN201811631417.2A CN109621210A (en) | 2018-12-29 | 2018-12-29 | A kind of figure-eight coil and its configuring management method for transcranial magnetic stimulation control experiment |
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| CN201811631417.2A CN109621210A (en) | 2018-12-29 | 2018-12-29 | A kind of figure-eight coil and its configuring management method for transcranial magnetic stimulation control experiment |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643817A (en) * | 2020-06-15 | 2020-09-11 | 天津大学 | Triangular net personalized multi-coil transcranial magnetic stimulation array and control method thereof |
| CN112755396A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | Transcranial magnetic stimulation system |
| CN112755395A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | True and false pulse magnetic stimulation therapeutic instrument |
| CN113440731A (en) * | 2021-08-11 | 2021-09-28 | 成都理工大学 | Asymmetric special-shaped coil for craniocerebral electromagnetic stimulation and craniocerebral electromagnetic stimulation system |
-
2018
- 2018-12-29 CN CN201811631417.2A patent/CN109621210A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643817A (en) * | 2020-06-15 | 2020-09-11 | 天津大学 | Triangular net personalized multi-coil transcranial magnetic stimulation array and control method thereof |
| CN111643817B (en) * | 2020-06-15 | 2021-12-03 | 天津大学 | Triangular net personalized multi-coil transcranial magnetic stimulation array and control method thereof |
| CN112755396A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | Transcranial magnetic stimulation system |
| CN112755395A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | True and false pulse magnetic stimulation therapeutic instrument |
| CN112755396B (en) * | 2021-01-21 | 2023-03-24 | 武汉依瑞德医疗设备新技术有限公司 | Transcranial magnetic stimulation system |
| CN112755395B (en) * | 2021-01-21 | 2023-04-14 | 武汉依瑞德医疗设备新技术有限公司 | True and false pulse magnetic stimulation therapeutic instrument |
| CN113440731A (en) * | 2021-08-11 | 2021-09-28 | 成都理工大学 | Asymmetric special-shaped coil for craniocerebral electromagnetic stimulation and craniocerebral electromagnetic stimulation system |
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Effective date of registration: 20201211 Address after: Chengkai international building, 355 Hongqiao Road, Xuhui District, Shanghai 200030 Applicant after: Song Jin Address before: Room 101, unit 1, building 6, Guodian Huayuan, yard 12, Anding Road, Chaoyang District, Beijing 100029 Applicant before: BEIJING SHENCHANG TECHNOLOGY DEVELOPMENT Co.,Ltd. |
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Application publication date: 20190416 |