CN110193143B - Transcranial magnetic stimulation system and method - Google Patents
Transcranial magnetic stimulation system and method Download PDFInfo
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- CN110193143B CN110193143B CN201910318507.4A CN201910318507A CN110193143B CN 110193143 B CN110193143 B CN 110193143B CN 201910318507 A CN201910318507 A CN 201910318507A CN 110193143 B CN110193143 B CN 110193143B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
Abstract
The application discloses transcranial magnetic stimulation systems and methods comprising: the device comprises an upper computer module and two stimulation modules. The upper computer module is connected with a first stimulation module in the two stimulation modules, and the first stimulation module is connected with a second stimulation module; the upper computer module is used for sending a plurality of paths of control signals to the first stimulation module; the first stimulation module is used for receiving the multipath control signals, controlling the coil to discharge according to a first path of control signals corresponding to the stimulation module, and sending other paths of control signals to a second stimulation module connected with the first path of control signals; the second stimulation module is used for receiving the other paths of control signals sent by the first stimulation module, and controlling the coil to discharge according to the second path of control signals corresponding to the local stimulation module in the other paths of control signals. The upper computer module is used for controlling the plurality of stimulation modules simultaneously, so that a plurality of targets can be stimulated synchronously, the stimulation intensity, the stimulation frequency and the stimulation time of each stimulation module can be respectively adjusted, and the stimulation effect is improved.
Description
Technical Field
The present application relates to the field of electrical stimulation, and in particular to a transcranial magnetic stimulation system and method.
Background
Transcranial magnetic stimulation (Transcrania Magnetic Stimulation, TMS) technology has been perfected in recent years, and therapeutic effects for treating cerebral nerve diseases by magnetic stimulation have been widely accepted. With the acceleration of the modern life rhythm, the pressure of people is increased, the occurrence of neurological diseases is more and more, and the occurrence of transcranial magnetic stimulation technology just solves the problems.
The transcranial magnetic stimulation technology utilizes a magnetic stimulation coil to generate a high-intensity pulse magnetic field to stimulate cerebral nerves to change the electrical activity of nerve cells in the brain, so as to achieve the aim of treating neurological diseases. The non-invasive therapeutic scheme is safe and reliable, has obvious therapeutic effect and is accepted by patients.
The traditional magnetic stimulation device can only focus on a certain target point for treatment, but the treatment effect of the mode on certain nerve diseases is not obvious.
In view of the foregoing, there is a need for a system and method that can simultaneously stimulate multiple targets.
Disclosure of Invention
To address the above issues, the present application proposes a transcranial magnetic stimulation system and method.
In one aspect, the present application proposes a transcranial magnetic stimulation system comprising: the upper computer module and two stimulation modules, wherein,
the upper computer module is connected with a first stimulation module in the two stimulation modules, and the first stimulation module is connected with a second stimulation module;
the upper computer module is used for sending a plurality of paths of control signals to the first stimulation module;
the first stimulation module is used for receiving the multipath control signals, controlling the coil to discharge according to a first path of control signals corresponding to the stimulation module, and sending other paths of control signals to a second stimulation module connected with the first path of control signals;
and the second stimulation module is used for receiving the other paths of control signals sent by the first stimulation module and controlling the coil to discharge according to the second path of control signals corresponding to the local stimulation module in the other paths of control signals.
Preferably, the system further comprises N stimulation modules connected in sequence with the second stimulation module;
the second stimulation module is further used for sending control signals except the first path of control signals and the second path of control signals in the multipath control signals to the stimulation module connected with the second stimulation module;
and the ith stimulation module in the N stimulation modules is used for receiving the control signals sent by the upper stimulation modules and controlling the coil to discharge according to the ith control signal corresponding to the ith stimulation module in the control signals sent by the upper stimulation modules.
Preferably, in the case that the i-th stimulation module is connected to the lower-stage stimulation module, the i-th stimulation module transmits other control signals except the i-th control signal among the multiple control signals received from the upper-stage stimulation module to the lower-stage stimulation module connected to the i-th stimulation module.
Preferably, the stimulation module comprises: the device comprises a control signal processing unit, a high-voltage pulse power supply unit, an energy storage unit, a switch, a coil and a lead-out interface;
the control signal processing unit is respectively connected with the high-voltage pulse power supply unit, the switch and the lead-out interface, the high-voltage pulse power supply unit is connected with the energy storage unit, and the switch is connected with the coil;
the control signal processing unit is used for receiving the control signal sent by the upper-level stimulation module, controlling the high-voltage pulse power supply unit and the switch according to the control signal corresponding to the stimulation module, and sending the control signal to be sent to the lower-level stimulation module to the extraction interface;
the high-voltage pulse power supply unit is used for charging the energy storage unit according to the control signal;
the energy storage unit is used for storing electric energy;
the switch is used for releasing the electric energy in the energy storage unit into the coil according to the control signal, and the coil is instantaneously discharged;
the coil is used for receiving instantaneous electric energy passing through the switch and generating magnetic stimulation pulses;
the extraction interface is used for sending a control signal to be sent to a subordinate stimulation module to the stimulation module connected with the extraction interface.
Preferably, the coils comprise circular ring stimulation coils, 8-shaped stimulation coils, and/or double 8-shaped stimulation coils.
Preferably, the housings of the 8-shaped stimulation coils and the double 8-shaped stimulation coils are provided with marks of coil focuses.
Preferably, the stimulating module further comprises an emergency stop unit for monitoring the temperature of the coil, when the temperature of the coil exceeds a safety range, the stimulating module is controlled to stop stimulating and perform over-temperature warning until the temperature is restored to be within a normal range, the warning is eliminated, and the stimulating module is controlled to resume operation.
Preferably, the upper computer module is specifically configured to send multiple paths of control signals corresponding to the number of the stimulation modules, and set stimulation intensities, stimulation frequencies and stimulation times of the multiple stimulation modules.
Preferably, the upper computer module is further used for displaying basic information of the patient, a treatment scheme memo, coil types, equipment working states, working modes, coil temperature display, stimulation progress and stimulation modes.
In a second aspect, the present application proposes a transcranial magnetic stimulation method comprising the steps of:
the upper computer module sends a multi-path control signal to the first stimulation module;
the first stimulation module receives the multipath control signals, controls the coil to discharge according to a first path of control signals corresponding to the first stimulation module, and sends other paths of control signals to a second stimulation module connected with the first stimulation module;
the second stimulation module receives the other paths of control signals sent by the first stimulation module, and controls the coil to discharge according to a second path of control signals corresponding to the local stimulation module in the other paths of control signals.
The application has the advantages that: the upper computer module is used for simultaneously controlling the plurality of stimulation modules, so that a plurality of targets can be stimulated synchronously; and the stimulation intensity, the stimulation frequency and the stimulation time of each stimulation module can be respectively adjusted according to the treatment scheme, so that the stimulation effect is improved.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for the purpose of illustrating preferred embodiments and are not to be construed as limiting the application. Also, like reference numerals are used to designate like parts throughout the figures. In the drawings:
FIG. 1 is a schematic diagram of a transcranial magnetic stimulation system provided herein;
FIG. 2 is a schematic illustration of a stimulation module transposition connection of a transcranial magnetic stimulation system provided herein;
FIG. 3 is a schematic diagram of a transcranial magnetic stimulation system according to the present application coupled to N stimulation modules;
FIG. 4 is a schematic illustration of the connection of the stimulation modules of the transcranial magnetic stimulation system provided herein when N is equal to 1;
FIG. 5 is a schematic diagram of the connection of the stimulation modules of the transcranial magnetic stimulation system according to the present application when N equals 2;
FIG. 6 is a schematic diagram of a stimulation module of a transcranial magnetic stimulation system provided herein;
fig. 7 is a schematic diagram of steps of a transcranial magnetic stimulation method provided herein.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
According to an embodiment of the present application, there is provided a transcranial magnetic stimulation system, as shown in fig. 1, comprising: the upper computer module and two stimulation modules, wherein,
the upper computer module is connected with a first stimulation module in the two stimulation modules, and the first stimulation module is connected with a second stimulation module;
the upper computer module is used for sending a plurality of paths of control signals to the first stimulation module;
the first stimulation module is used for receiving the multipath control signals, controlling the coil to discharge according to a first path of control signals corresponding to the stimulation module, and sending other paths of control signals to a second stimulation module connected with the first path of control signals;
and the second stimulation module is used for receiving the other paths of control signals sent by the first stimulation module and controlling the coil to discharge according to the second path of control signals corresponding to the local stimulation module in the other paths of control signals.
The first stimulation module (main equipment) is one of two stimulation modules, and the first stimulation module is connected with the upper computer.
The second stimulation module (slave device) is one of the two stimulation modules, which is connected with the first stimulation module.
As shown in fig. 2, the connection sequence of the two stimulation modules and the upper computer can be exchanged, that is, the stimulation modules corresponding to the master device and the slave device can be exchanged.
As shown in fig. 3, the system further includes N stimulation modules sequentially connected to the second stimulation module;
the second stimulation module is further used for sending control signals except the first path of control signals and the second path of control signals in the multipath control signals to the stimulation module connected with the second stimulation module;
and the ith stimulation module in the N stimulation modules is used for receiving the control signals sent by the upper stimulation modules and controlling the coil to discharge according to the ith control signal corresponding to the ith stimulation module in the control signals sent by the upper stimulation modules.
And under the condition that the ith stimulation module is connected with the lower-level stimulation module, the ith stimulation module transmits other control signals except the ith control signal in the multipath control signals received from the upper-level stimulation module to the lower-level stimulation module connected with the ith stimulation module.
The connection order of the modules in the N stimulation modules can be exchanged with each other.
The N may be a natural number of 1, 2, 3, 4, 5 … …, etc.
As shown in fig. 4, taking n=1 as an example, the third stimulation module is connected to the second stimulation module. The third stimulation module is used for receiving the control signals sent by the upper-level stimulation module (the second stimulation module) and controlling the coil to discharge according to the control signals (the 3 rd path control signals) corresponding to the third stimulation module (the local stimulation module) in the control signals sent by the second stimulation module.
As shown in fig. 5, taking n=2 as an example, the third stimulation module is connected to the second stimulation module, and the fourth stimulation module is connected to the third stimulation module. The third stimulation module is used for receiving the control signals sent by the upper-level stimulation module (the second stimulation module), controlling the coil to discharge according to the 3 rd path of control signals corresponding to the third stimulation module (the local stimulation module) in the control signals sent by the second stimulation module, and sending the control signals except the 3 rd path of control signals in the received control signals to the fourth stimulation module (the lower-level stimulation module connected with the third stimulation module).
The fourth stimulation module is used for receiving the control signals sent by the superior stimulation module (the third stimulation module) and controlling the coil to discharge according to the control signals (the 4 th path of control signals) corresponding to the fourth stimulation module (the local stimulation module) in the control signals sent by the third stimulation module.
As shown in fig. 6, the stimulation module includes: the device comprises a control signal processing unit, a high-voltage pulse power supply unit, an energy storage unit, a switch, a coil and a lead-out interface;
the control signal processing unit is respectively connected with the high-voltage pulse power supply unit, the switch and the lead-out interface, the high-voltage pulse power supply unit is connected with the energy storage unit, and the switch is connected with the coil;
the control signal processing unit is used for receiving the control signal sent by the upper-level stimulation module, controlling the high-voltage pulse power supply unit and the switch according to the control signal corresponding to the stimulation module, and sending the control signal to be sent to the lower-level stimulation module to the extraction interface;
the high-voltage pulse power supply unit is used for charging the energy storage unit according to the control signal;
the energy storage unit is used for storing electric energy;
the switch is used for releasing the electric energy in the energy storage unit into the coil according to the control signal, and the coil is instantaneously discharged;
the coil is used for receiving instantaneous electric energy passing through the switch and generating magnetic stimulation pulses;
the extraction interface is used for sending a control signal to be sent to a subordinate stimulation module to the stimulation module connected with the extraction interface.
The number of the leading-out interfaces corresponds to the number of the stimulation modules in the system.
The switch comprises a thyristor switch.
The coils comprise annular stimulating coils, 8-shaped stimulating coils and/or double 8-shaped stimulating coils.
The coil also comprises a stimulation coil in an eccentric splayed mode.
The housings of the 8-shaped stimulation coils and the double 8-shaped stimulation coils are provided with marks of coil focuses so that workers can conveniently focus on areas needing stimulation during stimulation.
The stimulation module further comprises an emergency stop unit for monitoring the temperature of the coil, when the temperature of the coil exceeds a safety range (human body safety range), the stimulation module is controlled to stop stimulation, and over-temperature warning is carried out until the temperature is restored to be within a normal range, warning is eliminated, and the stimulation module is controlled to restore work.
The upper computer module is specifically used for sending multipath control signals corresponding to the number of the stimulation modules, and setting the stimulation intensity, the stimulation frequency and the stimulation time of the stimulation modules.
The upper computer module can also set synchronous stimulation interval time, working mode and other important parameters of each stimulation module.
The synchronous stimulation interval time of each stimulation module is set by setting the millisecond level of the stimulation coil of each stimulation module, controlling the stimulation coil of each stimulation module, and realizing the millisecond level synchronous interval of the discharge of each stimulation coil.
The upper computer module is also used for displaying basic information of a patient, a treatment scheme memo, coil types, equipment working states, working modes, coil temperature display, stimulation progress, stimulation modes and the like.
The upper computer module is also used for monitoring the working state of the whole system.
According to an embodiment of the present application, there is also provided a transcranial magnetic stimulation method, as shown in fig. 7, comprising the steps of:
the upper computer module sends a multi-path control signal to the first stimulation module;
the first stimulation module receives the multipath control signals, controls the coil to discharge according to a first path of control signals corresponding to the first stimulation module, and sends other paths of control signals to a second stimulation module connected with the first stimulation module;
the second stimulation module receives the other paths of control signals sent by the first stimulation module, and controls the coil to discharge according to a second path of control signals corresponding to the local stimulation module in the other paths of control signals.
The first stimulation module (main equipment) is one of two stimulation modules, and the first stimulation module is connected with the upper computer.
The second stimulation module (slave device) is one of the two stimulation modules, which is connected with the first stimulation module.
The connection sequence of the two stimulation modules and the upper computer can be exchanged, namely, the stimulation modules corresponding to the master device and the slave device can be exchanged.
In the system of the application, the upper computer module can realize multi-path synchronous multi-target stimulation by connecting a plurality of stimulation modules, so that the multi-target stimulation can be carried out on the area needing to be stimulated by using the plurality of stimulation modules synchronously, the stimulation intensity, the stimulation frequency and the stimulation time of each stimulation module can be respectively adjusted according to the treatment scheme, and the stimulation effect is improved.
The foregoing is merely a preferred embodiment of the present application, but the scope of the present application is not limited thereto, and any changes or substitutions easily contemplated by those skilled in the art within the technical scope of the present application should be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (8)
1. A transcranial magnetic stimulation system, comprising: the upper computer module and two stimulation modules, wherein,
the upper computer module is connected with a first stimulation module in the two stimulation modules, and the first stimulation module is connected with a second stimulation module;
the upper computer module is used for sending a plurality of paths of control signals to the first stimulation module;
the first stimulation module is used for receiving the multipath control signals, controlling the coil to discharge according to a first path of control signals corresponding to the stimulation module, and sending other paths of control signals to a second stimulation module connected with the first path of control signals;
the second stimulation module is used for receiving the other paths of control signals sent by the first stimulation module and controlling the coil to discharge according to a second path of control signals corresponding to the stimulation module in the other paths of control signals;
the system also comprises N stimulation modules which are sequentially connected with the second stimulation module;
the second stimulation module is further used for sending control signals except the first path of control signals and the second path of control signals in the multipath control signals to the stimulation module connected with the second stimulation module;
the ith stimulation module in the N stimulation modules is used for receiving the control signals sent by the upper stimulation module and controlling the coil to discharge according to the ith control signal corresponding to the ith stimulation module in the control signals sent by the upper stimulation module;
the stimulation module includes: the device comprises a control signal processing unit, a high-voltage pulse power supply unit, an energy storage unit, a switch, a coil and a lead-out interface;
the control signal processing unit is respectively connected with the high-voltage pulse power supply unit, the switch and the lead-out interface, the high-voltage pulse power supply unit is connected with the energy storage unit, and the switch is connected with the coil;
the control signal processing unit is used for receiving the control signal sent by the upper-level stimulation module, controlling the high-voltage pulse power supply unit and the switch according to the control signal corresponding to the stimulation module, and sending the control signal to be sent to the lower-level stimulation module to the extraction interface;
the high-voltage pulse power supply unit is used for charging the energy storage unit according to the control signal;
the energy storage unit is used for storing electric energy;
the switch is used for releasing the electric energy in the energy storage unit into the coil according to the control signal, and the coil is instantaneously discharged;
the coil is used for receiving instantaneous electric energy passing through the switch and generating magnetic stimulation pulses;
the extraction interface is used for sending a control signal to be sent to a subordinate stimulation module to the stimulation module connected with the extraction interface.
2. The transcranial magnetic stimulation system of claim 1, wherein in the case where the i-th stimulation module is connected to the lower-stage stimulation module, the i-th stimulation module transmits control signals other than the i-th control signal among the multiple control signals received from the upper-stage stimulation module thereof to the lower-stage stimulation module connected to the i-th stimulation module.
3. A transcranial magnetic stimulation system according to claim 1, wherein the coils comprise annular stimulation coils, 8-shaped stimulation coils and/or double 8-shaped stimulation coils.
4. A transcranial magnetic stimulation system according to claim 3, wherein the housing of the figure 8 stimulation coil and the double figure 8 stimulation coil has indicia of coil focus.
5. The transcranial magnetic stimulation system of claim 1 wherein the stimulation module further comprises a scram unit for monitoring the temperature of the coil, controlling the stimulation module to stop stimulation when the temperature of the coil exceeds a safe range, and performing an overtemperature warning until the temperature returns to within a normal range, eliminating the warning, and controlling the stimulation module to resume operation.
6. The transcranial magnetic stimulation system of claim 1, wherein the host computer module is specifically configured to send multiple control signals corresponding to the number of stimulation modules, and set stimulation intensities, stimulation frequencies, and stimulation times of the multiple stimulation modules.
7. The transcranial magnetic stimulation system of claim 1, wherein the host computer module is further configured to display patient basic information, treatment protocol notes, coil type, device operating status, mode of operation, coil temperature display, stimulation schedule, stimulation mode.
8. A transcranial magnetic stimulation method for use in a system according to any one of claims 1 to 7, comprising the steps of:
the upper computer module sends a multi-path control signal to the first stimulation module;
the first stimulation module receives the multipath control signals, controls the coil to discharge according to a first path of control signals corresponding to the first stimulation module, and sends other paths of control signals to a second stimulation module connected with the first stimulation module;
the second stimulation module receives the other paths of control signals sent by the first stimulation module, and controls the coil to discharge according to a second path of control signals corresponding to the local stimulation module in the other paths of control signals.
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