CN111643817A - Triangular net personalized multi-coil transcranial magnetic stimulation array and control method thereof - Google Patents
Triangular net personalized multi-coil transcranial magnetic stimulation array and control method thereof Download PDFInfo
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Abstract
The invention discloses a triangulation network personalized multi-coil transcranial magnetic stimulation array and a control method thereof, and belongs to the technical field of transcranial magnetic stimulation. The array includes: a series of hexagonal prism-shaped connecting nodes which can be controlled by a host computer to control the gating direction, and a series of coil sections which form an equilateral triangle. In the triangular mesh personalized multi-coil magnetic stimulation array provided by the invention, coil sections and nodes are utilized to form a series of adjacent equilateral triangular stimulation units, and personalized magnetic stimulation is realized by controlling the gating direction and the down-leading direction of the nodes through an upper computer. The novel transcranial magnetic stimulation coil array provided by the invention can be used for synchronously stimulating at a plurality of parts of the whole brain area, and is different from the traditional multi-coil magnetic stimulation array in that the shape, the size and the position of a stimulation unit can be selected. The stimulation form and the stimulation position of the coil array are flexible and changeable, and the personalized requirements on transcranial magnetic stimulation can be realized.
Description
Technical Field
The invention relates to the technical field of transcranial magnetic stimulation, in particular to a triangular mesh personalized multi-coil transcranial magnetic stimulation array and a control method thereof, which can realize personalized transcranial magnetic stimulation.
Background
Because the magnetic permeability of each part of the head is basically the same, when a magnetic field passes through high-impedance tissues such as a skull or a scalp, the magnetic field intensity of the magnetic field is hardly attenuated, and the intensity of induced current in brain tissues cannot be influenced by the existence of the high-impedance tissues, as shown in fig. 1. In the human brain, the impedance of scalp, fat and bone is high, and the induced current is proportional to the electrical conductivity of the tissue in the brain, so the intensity of the induced current is small, the excitation state of the brain pain receptor is hardly caused, and pain is not sensed. At present, transcranial magnetic stimulation technology is widely applied to brain function and cognitive science research.
The existing transcranial magnetic stimulation technology mostly adopts a single-channel coil for stimulation, such as a traditional O-shaped coil or an 8-shaped coil, and the stimulation mode can only stimulate one part at the same time. With the development of medical technology and engineering science, the single-channel magnetic stimulation device cannot meet higher requirements of transcranial magnetic stimulation on full-brain-domain multi-site synchronous stimulation, personalized stimulation modes, accurate stimulation positioning and the like, so that a multi-coil magnetic stimulation treatment mode is developed.
The study of multi-channel magnetic stimulation began in 1998 with several simple-structured single coils arranged in a certain spatial arrangement. The existing multi-coil transcranial magnetic stimulation technology mostly adopts square (as shown in figure 2.a), round (as shown in figure 2.b) and straight lead (as shown in figure 2.c) multi-coil arrays, and all use a certain shape as a basic unit to form a network structure. The circular coil has a gap between adjacent coils due to the shape of the coil itself, which makes it difficult to obtain high-resolution stimulation, and secondly, the size of the stimulation unit of the circular coil is fixed and unchanged, which does not allow for adjustment of the stimulation area and shape. Although the square coil and the straight wire coil solve the problem of circular coil resolution, the special shape of the coil can only stimulate in a rectangular or linear mode, and the flexibility of magnetic stimulation is difficult to meet in many cases.
In summary, the several multi-coil transcranial magnetic stimulation designs shown in fig. 2 have the problems of low resolution and difficult shape change due to limitations, which limits the development of multi-coil transcranial magnetic stimulation technology to some extent. In the process of realizing multi-coil transcranial magnetic stimulation, the shape, size and position of the stimulation coil are individually adjusted according to requirements, which cannot be realized by the traditional multi-coil scheme. Aiming at the current situation, the design provides a novel triangulation network personalized multi-coil transcranial magnetic stimulation array based on a triangulation network structure and a control method thereof.
Disclosure of Invention
The invention aims to provide a brand-new individual multi-coil transcranial magnetic stimulation array capable of covering the whole brain area and a control method thereof.
The technical scheme for realizing the purpose of the invention is as follows:
a triangulation personalized multi-coil transcranial magnetic stimulation array is characterized in that: the array is designed based on a triangular mesh structure, and is a mesh multi-coil array structure formed by closely arranging small equilateral triangles; the array comprises a series of hexagonal prism-shaped connecting nodes and a series of coil sections forming a small equilateral triangle, wherein the gating directions of the hexagonal prism-shaped connecting nodes can be independently controlled by an upper computer; the coil sections connected with the two opposite side surfaces of the same node form a certain angle, so that the array can form a curved surface to cover the whole brain area.
The array forms a curved surface by connecting two coil sections which are positioned in the same plane and connected by the same node above the top of the head in an angle of 156 degrees, the radian of the curved surface conforms to the curved surface shape of the skull of a human body, and the whole coil array can cover the whole brain area; the array consists of a series of small equilateral triangles, and the side length of each equilateral triangle is 20 mm; the TMS coils are closely arranged without intervals.
The node is gated by an upper computer, and the upper computer can select the current conduction direction in the node, so that a passage is formed between two coil sections connected to the same node in two directions; the upper computer can select the current down-leading direction in the node, so that the stimulating unit forms a coil structure.
The upper computer can control the node gating direction and the down-leading direction, the stimulation coils with different shapes, sizes and positions can be selected, the stimulation units are formed by connecting the paths among a plurality of nodes, the shapes of the stimulation units can be switched among any shapes which can be spliced by a plurality of equilateral triangles, and personalized transcranial magnetic stimulation is realized; the shape of the stimulation unit can be triangle, rhombus and hexagon, trapezoid or hexagram, and other shapes which can be formed by splicing equilateral triangles.
The structure of the node is hexagonal prism-shaped, and the node is divided into four layers from top to bottom, and the four layers are respectively connected with the coil sections; and power-on interfaces connected with the stimulation main circuit are arranged above and below the nodes.
Among a plurality of nodes forming one stimulation unit, only one node is used as a node for connecting the stimulation unit with the main stimulation circuit, the upper and lower power-on interfaces form a passage with the main stimulation circuit, and the current directions of the two power-on interfaces are opposite; the power-on interfaces of the other nodes do not form a path with the main stimulation circuit.
The interior of each layer of the four layers of the nodes is provided with a gating circuit with the same structure, a first relay and a second relay are respectively arranged in each direction of the side surfaces of the six directions of one node, the first relay is provided with four normally open contacts, and the normally open contacts are respectively positioned on each layer of the interior of the nodes; the second relay is provided with four normally open contacts and four normally closed contacts, and one normally open contact and one normally closed contact form a group of layers positioned in the node; one end of a normally open contact of the first relay is connected with the port of the coil section, and the other end of the normally open contact is connected with one end of the same layer of the normally open contact and one end of the normally closed contact of the second relay; the power on and power off of each relay in the node are controlled by the upper computer.
Normally open contacts of first relays on the sides of the six directions of the node are collectively represented by K11, K21, K31, K41, K51 and K61, normally open contacts of first relays on one to four layers of the node are respectively represented by K11a, K11b, K11c and K11d, normally closed contacts of second relays on one to four layers are represented by K12a, K12b, K12c and K12d, and normally open contacts of second relays on one to four layers are represented by K12A, K12B, K12C and K12D; normally open contacts of first relays in the direction of the node (II) are respectively represented by K21a, K21b, K21c and K21d, normally closed contacts of second relays in the direction of the node (II) are respectively represented by K22a, K22b, K22c and K22d, and normally open contacts of second relays in the direction of the node (II) are respectively represented by K22A, K22B, K22C and K22D; normally open contacts of a first relay in the direction of the node iii on the first layer to the fourth layer are respectively represented by K31a, K31b, K31c and K31d, normally closed contacts of a second relay in the direction of the node iii on the first layer to the fourth layer are represented by K32a, K32b, K32c and K32d, and normally open contacts of the second relay on the first layer to the fourth layer are represented by K32A, K32B, K32C and K32D; normally open contacts of the first relay in the direction of the node (r) at the first to fourth layers are respectively represented by K41a, K41b, K41c and K41d, normally closed contacts of the second relay in the direction of the node (r) at the first to fourth layers are respectively represented by K42a, K42b, K42c and K42d, and normally open contacts of the second relay at the first to fourth layers are respectively represented by K32A, K42B, K42C and K42D; normally open contacts of first relays in the direction of a node (c) at the first layer to the fourth layer are respectively represented by K51a, K51b, K51c and K51d, normally closed contacts of second relays in the direction of the node (c) at the first layer to the fourth layer are represented by K52a, K52b, K52c and K52d, and normally open contacts of second relays at the first layer to the fourth layer are represented by K52A, K52B, K52C and K52D; normally open contacts of a first relay in the node direction at one to four layers are respectively represented by K61a, K61b, K61c and K61d, normally closed contacts of a second relay in the node direction at one to four layers are represented by K62a, K62b, K62c and K62d, and normally open contacts of the second relay at one to four layers are represented by K62A, K62B, K62C and K62D;
one ends of normally open contacts K11a, K21a, K31a, K41a, K51a and K61a of the first relay are respectively connected with coil section ports in the directions of (1), (2), (iii), (iv), (v) and (iv), the other ends of the six normally open contacts of the first relay on the side surface of each direction are respectively connected with normally closed contacts K12a, K22a, K32a, K42a, K52a and K62a of the second relay in the same direction, the other ends of the six normally closed contacts are connected in a node center in a converging manner, and the converging point is called a central point;
the center point of the first layer of the node is connected with the power-on interface of the main stimulating circuit above the node, and the center points of the second layer, the third layer and the fourth layer of the node are not connected with the power-on interface; one end of a normally open contact of the second relay on the upper layer is connected with the central point of the next layer, and the other end of the normally open contact of the first relay on the same layer is connected with one end of the normally open contact of the first relay on the same layer; taking the direction of the first layer as an example, one end of the normally open contact K12D of the second relay of the fourth layer is connected with the power-on interface of the main stimulation circuit below the node, and the other end of the normally open contact K12D of the second relay of the fourth layer is connected with one end of the normally open contact of the first relay of the same layer.
A control method of a triangulation personalized multi-coil transcranial magnetic stimulation array comprises the following steps:
a) conducting control is carried out on a normally open contact of a relay between the node and the main stimulation circuit through an upper computer, so that the node is connected with the main stimulation circuit; one of the nodes of the stimulation unit is required to be used as a node forming a passage with the main stimulation circuit, and the other nodes are not conducted with the main stimulation circuit; the node which is conducted with the main stimulation circuit in one stimulation unit is required to be a down-leading node, one stimulation unit is provided with one down-leading node, and the down-leading node is selected by an operator;
b) conducting control is carried out on normally open contacts in all directions of the gating circuit of the four layers of the nodes through an upper computer, so that coil sections in two directions in one node are conducted; by controlling the plurality of nodes, the stimulation coils with different shapes can be obtained, so that the purpose of personalized stimulation is achieved.
The display interface of the upper computer comprises the following information:
displaying a tiled drawing of a triangular mesh personalized multi-coil transcranial magnetic stimulation array worn on a brain on one side of a display interface, and displaying a node control related menu on the other side, wherein the node control related menu comprises a node name selection frame, a gating direction selection, a gating confirmation key, a gating reset key, a pull-down direction selection, a pull-down confirmation key and a pull-down reset key; a node name selection frame is arranged in a node control related menu, each node has a name of the node, the node to be controlled can be selected in the node name selection frame through the name, and the corresponding node can be highlighted on a tiled image interface after the node is selected;
after the gating direction of the node is selected, gating is carried out on the corresponding direction of the node through a gating confirmation key, and if the gating information of the node needs to be reset, a gating reset key is pressed; if the node is used as a down-lead node, selecting the down-lead direction of the node, then down-leading the corresponding direction of the node through a down-lead confirmation key, and if down-lead information of the node needs to be reset, pressing down a down-lead reset key;
when a stimulation unit capable of stimulation has been formed in the array, the stimulation unit is highlighted at the corresponding location in the tile.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a brand-new multi-coil array transcranial magnetic stimulation design method based on a triangulation network structure. Compared with the traditional transcranial magnetic stimulation coil, the transcranial magnetic stimulation coil array designed based on the theory has the following characteristics and advantages:
(1) flexible variability of shape, size, number and position of transcranial magnetic stimulation coils can be achieved
Through the control of the nodes and the coil sections, the shape of the transcranial magnetic stimulation coil can be switched in various states such as triangle, diamond and hexagon, and stimulation coils with different sizes can be selected through the method; the stimulation coils can be generated at a plurality of positions in the coil array of the whole brain domain, the positions and the number of the coils are flexible and variable, and the individual requirements of transcranial magnetic stimulation can be realized.
(2) Capable of generating complex types of stimuli
Different from the traditional design scheme of the transcranial magnetic stimulation multi-coil array, which only can generate O-shaped coils or square coils, in the scheme, except for generating triangular and hexagonal coils with the stimulation effect similar to that of the O-shaped coils, rhombic coils with the stimulation effect similar to that of the square coils are generated, and coils in various shapes such as a six-mango star shape or a trapezoid shape can be generated by arranging nodes and coil sections through an operator. Can generate diversified stimulation schemes according to the requirements of various stimulation effects, and realize personalized magnetic stimulation.
Drawings
Fig. 1 is a schematic diagram of a transcranial magnetic stimulation technique.
Fig. 2 shows different designs of the multi-channel transcranial magnetic stimulation in the prior art, wherein (a) is a square coil array, (b) is a circular coil array, and (c) is a straight wire coil array.
Fig. 3 shows various shapes of stimulation units that can be produced by the present invention, (a) small triangular coils, (b) diamond coils, (c) hexagonal coils, and (d) larger triangular coils.
FIG. 4(a) is a schematic view of a hierarchical structure of nodes of an embodiment of a triangulated personalized multi-coil transcranial magnetic stimulation array in accordance with the present invention,
FIG. 4(b) is a schematic diagram of the connection between the nodes and the main stimulation circuit of an embodiment of the triangulated personalized multi-coil transcranial magnetic stimulation array of the present invention,
FIG. 4(c) is a schematic top view of a single-layer gating circuit in a node according to an embodiment of the invention, wherein: (i) are six directional side surfaces in the node,
fig. 4(d) is a schematic cross-sectional structure diagram of a node of an embodiment of the triangulation network personalized multi-coil transcranial magnetic stimulation array of the invention, which is sectioned in the direction of (r) and the direction of (r),
FIG. 4(e) is a schematic view showing the directions of (i) and (ii) of the single-layer conduction inside the node according to an embodiment of the triangulation network personalized multi-coil transcranial magnetic stimulation array,
figure 4(f) is a schematic view of the triangular gating direction,
FIG. 4(g) is a drawing-down diagram of the node (r), taking the conductive connection in the (r) direction and the (r) direction as an example,
FIG. 4(h) shows that the normal node has no downward indication, taking the conduction in the (r) direction and the (r) direction as an example,
fig. 4(i) is an example of connection of one stimulation unit.
Fig. 5 is a schematic diagram of a triangulated personalized multi-coil transcranial magnetic stimulation array worn on the head in accordance with the present invention.
Fig. 6 is a schematic view of a local tiling of a triangulated personalized multi-coil transcranial magnetic stimulation array of the present invention.
Fig. 7 is a schematic diagram of coil segments in a triangulated personalized multi-coil transcranial magnetic stimulation array in accordance with the present invention.
Figure 8(a) is a schematic diagram of the connection of a coil segment and two adjacent nodes,
fig. 8(b) is a schematic diagram of the connection of a plurality of coil segments and nodes.
Fig. 9 is a schematic view of the direction of the closing coil current.
Fig. 10 is a schematic view of an operation interface of the upper computer.
Fig. 11 is a schematic diagram of a minimal triangular stimulation coil implemented in accordance with the present invention.
Fig. 12 is a schematic diagram of an implementation of a diamond-shaped stimulation coil of the present invention.
Fig. 13 is a schematic diagram of an implementation of a hexagonal stimulation coil in accordance with the present invention.
Fig. 14 is a schematic diagram of a larger triangular shaped stimulation coil implemented in accordance with the present invention.
FIG. 15 is a simulation result of the current density induced by the minimal triangular stimulation coil to the lower scalp layer according to the present invention.
FIG. 16(a) is a schematic diagram showing the connection of the node to the stimulation circuit when using IGBT circuit control,
fig. 16(b) is a schematic diagram of a node internal single-layer circuit when the gate direction in the node is controlled using the IGBT circuit.
Detailed Description
The invention provides a design scheme of a multi-coil transcranial magnetic stimulation array capable of covering the whole brain. The coil array is composed of a series of hexagonal connection nodes which can be controlled by an upper computer to control the gating direction, and a series of coil sections which form an equilateral triangle. The coil sections are connected with the side faces of the nodes to form a series of triangular net structures which are closely arranged, and the coil sections connected with the two opposite side faces of the same node form a certain angle, so that the array can form a curved surface to cover the whole brain area.
Each node in the coil array is independently controlled by an upper computer, and the upper computer can control whether the node is connected with the main stimulation circuit or not and can control the gating direction inside the node, so that the shape of the stimulation coil is controlled.
The electrified coil can generate a magnetic field around the electrified coil, the traditional transcranial magnetic stimulation coil can generate a magnetic field with the same waveform vertical to the plane of the coil after being electrified with time-varying current, and the changed magnetic field acts on the human brain to induce an induced electric field, so that nerve cells of the human brain are stimulated. In the scheme, the combined closed coil is electrified with time-varying current, so that a magnetic field can be generated in the closed coil to stimulate the brain. Different stimulation effects can be generated by combining the closed coils (stimulation units) with different shapes and sizes, and the closed coils arranged at different positions can realize simultaneous stimulation of multiple parts of the whole brain area.
The invention is further described below with reference to the accompanying drawings.
The invention provides a triangulation personalized multi-coil transcranial magnetic stimulation array scheme as shown in figure 5. The scheme is characterized in that a series of hexagonal connection nodes capable of being independently controlled by an upper computer to gate the direction and a series of coil sections forming an equilateral triangle are arranged. The coil sections are connected with the side surfaces of the nodes to form a series of triangular net structures which are closely arranged, and a certain angle is formed between the coil sections which are connected with the two opposite side surfaces of the same node. The coil array is formed by connecting two coil sections which are positioned in the same plane and connected through the same node above the top of the head in an angle of 156 degrees, the radian of the curved surface conforms to the curved surface shape of the skull of a human body, and the whole coil array can cover the whole brain area. The stimulation can be synchronously performed at a plurality of parts of the whole brain area, and the difference from the traditional multi-coil magnetic stimulation array is that the shape, the size and the position of the stimulation unit can be selected. The stimulation form and the stimulation position of the coil array are flexible and changeable, and the personalized requirements on transcranial magnetic stimulation can be realized. The TMS coils are closely arranged without intervals.
The upper computer controls the node gating direction, the shape of the stimulating coil formed by the connection of the paths among the nodes can be triangular (as shown in fig. 3.a), rhombic (as shown in fig. 3.b), hexagonal (as shown in fig. 3.c) and the like, and the size of the stimulating coil can be selected by the method (as shown in fig. 3.a and 3.d, the stimulating coils have the same shape and different sizes). The stimulation units with different shapes and sizes are obtained by controlling the nodes through the upper computer.
Fig. 6 is a partial tiling schematic diagram of the multi-coil array, which includes a series of hexagonal connection nodes capable of being controlled by the upper computer to control the gating direction and a series of coil segments forming an equilateral triangle. The coil sections are connected with the side surfaces of the nodes to form a series of triangular net structures which are closely arranged.
The coil node has a hexagonal prism shape, and is divided into four layers from top to bottom as shown in fig. 4(a), and the four layers are respectively connected with the four layers of the coil segment. The upper and lower parts of the node are provided with an electrifying interface connected with the stimulation main circuit, and the connection between the node and the stimulation main circuit is controlled by a normally open contact, as shown in fig. 4 (b). The four layers in the middle of the node are connected with the coil section. The gating circuits with the same structure are arranged in each layer of the four layers of the nodes, the top view of the gating circuit of the single layer in the nodes is shown in fig. 4(c), normally open contacts and normally closed contacts are adopted, the conduction and the closing of corresponding road sections can be controlled by controlling the closing of the corresponding normally open contacts in the diagram, the gating circuits in the directions of the first layer and the second layer of the single node are controlled by an upper computer, and the shape of a coil can be selected. (taking the first layer as an example), a first relay and a second relay are respectively arranged in each of six direction sides of a node, wherein normally open contacts of the first relays are respectively represented by K11, K21, K31, K41, K51 and K61, normally open contacts of the first relays in the direction of the node (r) are respectively represented by K11a, K11b, K11c and K11d in one to four layers, a total of four normally open contacts and four normally closed contacts of the second relays are represented by K12a, K12b, K12c and K12d in one to four layers, normally open contacts of the second relays in one to four layers are represented by K12A, K12B, K12C and K12D, and the contact representation methods in other directions are similar.
Normally open contacts exist between two adjacent layers, taking the first layer as an example, one ends of normally open contacts K11a, K21a, K31a, K41a, K51a and K61a of a first relay are respectively connected with coil section ports in the directions of (i), (ii), (iii), (iv), (v) and (sixth), the other ends of the six normally open contacts are respectively connected with normally closed contacts K12a, K22a, K32a, K42a, K52a and K62a of a second relay in the same direction, the other ends of the six normally closed contacts are converged and connected in the center of a node, and the converged point is called a central point. The center point of the first layer of the node is connected with the power-on interface of the main stimulating circuit above the node, and the center points of the second layer, the third layer and the fourth layer of the node are not connected with the power-on interface.
The cross-sectional view of the node cut along the directions of (i) and (iv) is shown in fig. 4(d), taking the direction of (i) as an example, the first relay has four normally open contacts respectively located at each layer inside the node, the second relay has four normally open contacts and four normally closed contacts, and one normally open contact and one normally closed contact form a group located at each layer inside the node. One end of a normally open contact of the first relay is connected with the port of the coil section, and the other end of the normally open contact is connected with one end of the same layer of the second relay and one end of the normally closed contact. The other end of the normally closed contact K12a of the second relay on the first layer is connected to the power-on interface of the main stimulation circuit above the node, the other end of the normally open contact K12A of the second relay on the first layer is connected to one end of the normally closed contact K12b of the second relay on the next layer, the other end of the normally closed contact K12b is connected with one end of the normally open contact K11b of the first relay on the same layer and one end of the normally open contact K12B of the second relay, the other end of K11b is connected to the coil section port of the second layer, and the other end of K12B is connected to one end of the normally closed contact K12c of the second relay on the next layer; and repeating the connection process to connect the circuits of the third layer and the fourth layer, wherein one end, facing the center of the node, of the normally open contact K12D of the second relay at the lowest layer is connected to the electrical interface of the stimulation main circuit below the node, the other end of the normally open contact K12D is connected with the normally open contact K11d of the first relay at the same layer, and the circuit structures of the other four layers in all directions are similar. The connection point of K12a and K42a, namely the center point of the first layer, is connected with K22a, K32a, K52a and K62a besides K12a and K42a, the four normally closed contacts are not shown in the cross section, and the connection of the rest layers is similar.
The power on and power off of each relay in the node are controlled by the upper computer. For one relay, when the relay is electrified, the corresponding normally open contact is closed, the normally closed contact is opened, when the relay is not electrified, the corresponding normally open contact is opened, and the normally closed contact is closed. Taking the direction of the nodes as an example, when the first relay is electrified, the normally open contacts K11a, K11b, K11c and K11d are closed, and when the first relay is not electrified, the normally open contacts K11a, K11b, K11c and K11d are opened; when the second relay is powered on, the normally closed contacts K12a, K12b, K12c and K12d are closed, the normally open contacts K12A, K12B, K12C and K12D are opened, and when the second relay is powered on, the normally closed contacts K12a, K12b, K12c and K12d are opened, and the normally open contacts K12A, K12B, K12C and K12D are closed.
The control method for the nodes comprises the following steps:
a) and conducting and controlling a normally open contact of a relay between the node and the main stimulation circuit through the upper computer, so that the node is connected with the main stimulation circuit. One of the nodes of the stimulation unit is required to be used as a node forming a passage with the main stimulation circuit, and the other nodes are not conducted with the main stimulation circuit. The node which is conducted with the main stimulation circuit in one stimulation unit is required to be a down-leading node, one stimulation unit is provided with one down-leading node, and the down-leading node can be selected by an operator; drop node stimulation unit
b) The upper computer conducts conduction control on the normally open contacts in all directions of the gating circuit of the four layers of the nodes, so that coil sections in two directions in one node are conducted, as shown in a top view of a first layer when the first layer and the fourth layer of the nodes are conducted, a gray part is an internal passage of the node, the normally open contacts K11a and K41a are closed by controlling the first relays in the first direction and the fourth direction to be electrified, the normally closed contacts K12a and K42a are kept closed by controlling the second relays in the first direction and the fourth direction to be deenergized, and a passage shown in a gray part in the figure is obtained. When the current flows in from the direction of (r), the current flows out from the direction of (r), and when the current flows in from the direction of (r), the current flows out from the direction of (r). By controlling the plurality of nodes, the stimulation coils with different shapes can be obtained, so that the purpose of personalized stimulation is achieved. A triangular coil can be formed: the nodes at three angular positions of the triangular stimulating unit are gated, and circuits at two sides of the 60-degree angle in the triangular are gated, so that the triangular stimulating unit is formed, as shown in fig. 4 (f).
In order to form a coil structure, a circuit with one downward lead is needed between two adjacent layers, so that a node is needed to be selected in one stimulating unit to lead a circuit in a coil downward, as shown in fig. 4(g), the circuit downward lead is shown in the direction of the node, and by taking sectional views in the direction of the node and the direction of the node as examples, by controlling a first relay in the direction of the node and the direction of the node to be powered on, a corresponding normally open contact is closed, then controlling a second relay in the direction of the node to be powered on, a corresponding normally open contact is closed, a normally closed contact is opened, controlling a second relay in the direction of the node to be powered off, a corresponding normally open contact is kept open, a normally closed contact is kept closed, a circuit shown in a gray part in fig. 4(g) is formed, and the node is called as a downward lead node. One stimulating unit has only one downward leading node, and the other nodes do not carry out passage downward leading, as shown in a sectional view in the direction of (r) and the direction of (r) in a figure 4(h), a first relay in the direction of (r) and the direction of (r) is powered on, a second relay is powered off, a node internal passage shown in the figure 4(h) is obtained, and the passage condition is that a common node is conducted in the direction of (r) and the direction of (r). Taking a stimulation unit with three nodes as an example, as shown in fig. 4(i), in order to visually show the corresponding connection mode, the image is tiled, the middle node is used as a down-leading node, the nodes on two sides are used as common nodes, and assuming that current flows in from above the down-leading node, the current can flow down layer by layer through the gray part path in the figure until flows out from the lower conduction interface of the down-leading node, so as to form a coil structure.
In addition, the present invention can also select switching modes such as an IGBT anti-parallel structure to realize gate control and pull-down node selection control in different directions, as shown in fig. 16(a) and 16 (b).
The coil segments connected to the nodes are shown in fig. 7, the coil segments are composed of good conductors and insulating layers wrapped outside the good conductors, one coil segment has four layers, so that a coil with 4 turns can be formed with the nodes, the connection of the coil segment to two adjacent nodes is shown in fig. 8(a), and the connection of a plurality of nodes and the coil is shown in fig. 8 (b).
By setting the gating directions of the nodes, various shapes of the magnetic stimulation coil can be obtained, taking a minimum triangular unit as an example, three adjacent nodes A, B and C are selected as connecting nodes, the gating A, B and the gating C are towards the directions of two sides of the triangle with an angle of 60 degrees, the node B is selected as a down-lead node, the adjacent two layers of coils are connected and are used as nodes for connecting the stimulation main circuits, and the current direction of the whole stimulation unit is shown as a black thickened directional line segment in fig. 9.
The requirements of the stimulation shape, size and position of the coil are determined by the actual condition of the patient and are controlled by an upper computer. The display interface of the upper computer is shown in fig. 10, and includes the following information:
displaying a tiled drawing of a triangular mesh personalized multi-coil transcranial magnetic stimulation array worn on a brain on one side of a display interface, and displaying a node control related menu on the other side, wherein the node control related menu comprises a node name selection frame, a gating direction selection, a gating confirmation key, a gating reset key, a pull-down direction selection, a pull-down confirmation key and a pull-down reset key;
each node has a name, the node to be controlled can be selected on the right panel through the name, and the node can be highlighted on the left interface after being selected. After the gating direction of the node is selected, the corresponding direction of the node is gated through a gating confirmation key, and if the node gating information needs to be reset, a gating reset key is pressed. If the node is used as a down-lead node, selecting the down-lead direction of the node, then down-leading the corresponding direction of the node through a down-lead confirmation key, and if the down-lead information of the node needs to be reset, pressing down a down-lead reset key. It is noted that there is one and only one down node in one stimulation unit, and the down node must be the node connecting the stimulation unit with the main stimulation circuit.
When a stimulation unit capable of stimulation has been formed in the array, the stimulation unit is highlighted in the corresponding position in the left image.
Buttons of different areas of the human brain can be arranged in the tile map interface, and the array of the currently selected area is displayed in the array display window of the tile map interface by selecting the different areas of the human brain; or the user can directly select the approximate region needing to be stimulated and researched through a mouse box, and then the approximate region is subjected to personalized control.
Based on the triangular network structure, transcranial magnetic stimulation coils of other shapes can be constructed:
a) constructing a diamond coil: the minimum rhombic coil consists of two adjacent triangular units with a common side, circuits facing two sides of a 60-degree angle in the rhombus are gated in two nodes connected by a long symmetry axis of the rhombus, and circuits facing two sides of a 120-degree angle in the rhombus are gated in two nodes connected by a short symmetry axis of the rhombus, so that the minimum rhombic coil is formed;
b) constructing a hexagonal coil: the minimum hexagonal coil consists of six adjacent triangular units with a common vertex, circuits facing the two sides of the 120-degree angle in the hexagon are gated in six nodes of the hexagon, and the node in the center of the hexagon is not gated in any direction, so that the minimum hexagonal coil is formed;
c) constructing a larger triangular coil: the larger triangular coil is composed of four triangular units, one triangular unit is positioned in the center, and the other three triangular units respectively have a common side with the central triangular unit. The nodes on the three corners of the larger triangle gate the circuits facing to the two sides of the 60-degree angle in the triangle, and the three nodes on the three sides of the triangle gate the circuits in the same direction as the sides of the triangle, so that a larger triangle coil is obtained;
the number of the stimulating coils is determined according to the required stimulating effect, the plurality of parts of the head are arranged according to the arrangement mode of a single coil, a plurality of single-channel transcranial magnetic stimulating coils can be generated simultaneously, and therefore the multi-channel transcranial magnetic stimulation is realized.
As shown in fig. 11, by setting the conduction direction of each node, it is possible to produce in a coil arrayTriangular stimulating coils with black lines as outlines in the figure can be obtained by gating ① and ② directions of an A node, ③ and ④ directions of a B node and ⑤ and ⑥ directions of a C node through an upper computer, wherein the perimeter of a small equilateral triangular stimulating unit is 20mm, the diameter of a lead adopted by each layer in a coil section is 2mm, the number of turns is 4, the height of the coil section is 8mm, and the area of the coil is 173mm2。
By setting the conduction directions of the individual nodes, diamond shaped stimulation coils can be generated in the coil array, as shown in fig. 12. The rhombic stimulating coil with black lines as the outline in the figure can be obtained by gating the directions of the A node and the fifth node by the upper computer, gating the directions of the B node and the third node, gating the directions of the C node and the sixth node and gating the directions of the D node.
By setting the conduction directions of the individual nodes, a hexagonal stimulating coil can be created in the coil array, as shown in fig. 13. The upper computer is used for gating the directions of the node A and the node V, the directions of the node B and the node B, the directions of the node C and the node C, the directions of the node D and the node D, the directions of the node E and the node V, the directions of the node F and the node V, and the middle node is not gated in any direction, so that the hexagonal stimulating coil with black lines as the outline in the figure can be obtained.
By setting the conduction directions of the various nodes, as shown in fig. 14, a larger triangular stimulation coil can be produced in the coil array. The upper computer is used for gating the directions of the node A and the node B, the directions of the node B and the node B, the directions of the node C and the node C, the directions of the node D and the node D, the directions of the node E and the node F, and the directions of the node F and the node F, so that the large triangular stimulating coil with black lines as the outline in the figure can be obtained.
Fig. 15 shows a distribution diagram of induced current density obtained when the smallest triangular coil is stimulated in the present invention, and the distribution diagram is annularly distributed below the stimulation region, and conforms to the current density distribution corresponding to the conventional O-shaped coil. Based on the simulation result, the triangular mesh array provided by the scheme can be found to meet the design index of the coil, so that the scheme has certain feasibility.
The main stimulation circuit in the invention is a conventional circuit in the existing transcranial magnetic stimulation device.
Nothing in this specification is said to apply to the prior art.
Claims (10)
1. A triangulation personalized multi-coil transcranial magnetic stimulation array is characterized in that: the array is designed based on a triangular mesh structure, and is a mesh multi-coil array structure formed by closely arranging small equilateral triangles; the array comprises a series of hexagonal prism-shaped connecting nodes and a series of coil sections forming a small equilateral triangle, wherein the gating directions of the hexagonal prism-shaped connecting nodes can be independently controlled by an upper computer; the coil sections connected with the two opposite side surfaces of the same node form a certain angle, so that the array can form a curved surface to cover the whole brain area.
2. The stimulation array of claim 1, wherein the array is curved by the 156 ° connection of two coil segments in the same plane connected by the same node above the vertex, the curvature of the curved surface conforming to the curved shape of the human skull, the entire coil array covering the whole brain area; the TMS coils are closely arranged without intervals.
3. The stimulation array of claim 1, wherein: the node is gated by an upper computer, and the upper computer can select the current conduction direction in the node, so that a passage is formed between two coil sections connected with the same node in two directions; the upper computer can select the current down-leading direction in the node to enable the stimulation unit to form a coil structure; and the gating control and the selection control of the down-leading node in different directions are realized by an IGBT (insulated gate bipolar transistor) anti-parallel structure or a relay mode.
4. The stimulation array of claim 1, wherein: the upper computer can control the node gating direction and the down-leading direction, the stimulation coils with different shapes, sizes and positions can be selected, the stimulation units are formed by connecting the paths among a plurality of nodes, the shapes of the stimulation units can be switched among any shapes which can be spliced by a plurality of equilateral triangles, and personalized transcranial magnetic stimulation is realized; the shape of the stimulation unit is triangle, diamond, hexagon, trapezoid or hexagram.
5. The stimulation array of claim 4, wherein: among a plurality of nodes forming the stimulation unit, only one node is used as a node for connecting the stimulation unit with the main stimulation circuit, the upper and lower power-on interfaces form a passage with the main stimulation circuit, and the current directions of the two power-on interfaces are opposite; the power-on interfaces of the other nodes do not form a path with the main stimulation circuit.
6. The stimulation array of claim 1, wherein: the structure of the node is hexagonal prism-shaped, and the node is divided into four layers from top to bottom, and the four layers are respectively connected with the coil sections; and power-on interfaces connected with the stimulation main circuit are arranged above and below the nodes.
7. The stimulation array of claim 6, wherein: the interior of each layer of the four layers of the nodes is provided with a gating circuit with the same structure, a first relay and a second relay are respectively arranged in each direction of the side surfaces of the six directions of one node, the first relay is provided with four normally open contacts, and the normally open contacts are respectively positioned on each layer of the interior of the nodes; the second relay is provided with four normally open contacts and four normally closed contacts, and one normally open contact and one normally closed contact form a group of layers positioned in the node; one end of a normally open contact of the first relay is connected with the port of the coil section, and the other end of the normally open contact is connected with one end of the same layer of the normally open contact and one end of the normally closed contact of the second relay; the power on and power off of each relay in the node are controlled by the upper computer.
8. The stimulation array of claim 7, wherein the normally open contacts of the first relays on the six direction sides of the node are collectively represented by K11, K21, K31, K41, K51 and K61, the normally open contacts of the first relays on the (r) direction of the node are respectively represented by K11a, K11b, K11c and K11d on the one to four layers, the four normally open contacts and the four normally closed contacts of the second relays are collectively represented by K12a, K12b, K12c and K12d on the one to four layers, and the normally open contacts of the second relays on the one to four layers are represented by K12A, K12B, K12C and K12D; normally open contacts of first relays in the direction of the node (II) are respectively represented by K21a, K21b, K21c and K21d, normally closed contacts of second relays in the direction of the node (II) are respectively represented by K22a, K22b, K22c and K22d, and normally open contacts of second relays in the direction of the node (II) are respectively represented by K22A, K22B, K22C and K22D; normally open contacts of a first relay in the direction of the node iii on the first layer to the fourth layer are respectively represented by K31a, K31b, K31c and K31d, normally closed contacts of a second relay in the direction of the node iii on the first layer to the fourth layer are represented by K32a, K32b, K32c and K32d, and normally open contacts of the second relay on the first layer to the fourth layer are represented by K32A, K32B, K32C and K32D; normally open contacts of the first relay in the direction of the node (r) at the first to fourth layers are respectively represented by K41a, K41b, K41c and K41d, normally closed contacts of the second relay in the direction of the node (r) at the first to fourth layers are respectively represented by K42a, K42b, K42c and K42d, and normally open contacts of the second relay at the first to fourth layers are respectively represented by K32A, K42B, K42C and K42D; normally open contacts of first relays in the direction of a node (c) at the first layer to the fourth layer are respectively represented by K51a, K51b, K51c and K51d, normally closed contacts of second relays in the direction of the node (c) at the first layer to the fourth layer are represented by K52a, K52b, K52c and K52d, and normally open contacts of second relays at the first layer to the fourth layer are represented by K52A, K52B, K52C and K52D; normally open contacts of a first relay in the node direction at one to four layers are respectively represented by K61a, K61b, K61c and K61d, normally closed contacts of a second relay in the node direction at one to four layers are represented by K62a, K62b, K62c and K62d, and normally open contacts of the second relay at one to four layers are represented by K62A, K62B, K62C and K62D;
one ends of normally open contacts K11a, K21a, K31a, K41a, K51a and K61a of the first relay are respectively connected with coil section ports in the directions of (1), (2), (iii), (iv), (v) and (iv), the other ends of the six normally open contacts of the first relay on the side surface of each direction are respectively connected with normally closed contacts K12a, K22a, K32a, K42a, K52a and K62a of the second relay in the same direction, the other ends of the six normally closed contacts are connected in a node center in a converging manner, and the converging point is called a central point;
the center point of the first layer of the node is connected with the power-on interface of the main stimulating circuit above the node, and the center points of the second layer, the third layer and the fourth layer of the node are not connected with the power-on interface; one end of a normally open contact of the second relay on the upper layer is connected with the central point of the next layer, and the other end of the normally open contact of the first relay on the same layer is connected with one end of the normally open contact of the first relay on the same layer; taking the direction of the first layer as an example, one end of the normally open contact of the second relay on the fourth layer is connected with the power-on interface of the stimulation main circuit below the node, and the other end of the normally open contact of the second relay on the fourth layer is connected with one end of the normally open contact of the first relay on the same layer.
9. A control method of a triangulation personalized multi-coil transcranial magnetic stimulation array comprises the following steps:
a) conducting control is carried out on a normally open contact of a relay between the node and the main stimulation circuit through an upper computer, so that the node is connected with the main stimulation circuit; one of the nodes of the stimulation unit is required to be used as a node forming a passage with the main stimulation circuit, and the other nodes are not conducted with the main stimulation circuit; the node which is conducted with the main stimulation circuit in one stimulation unit is required to be a down-leading node, one stimulation unit is provided with one down-leading node, and the down-leading node is selected by an operator;
b) conducting control is carried out on normally open contacts in all directions of the gating circuit of the four layers of the nodes through an upper computer, so that coil sections in two directions in one node are conducted; by controlling the plurality of nodes, the stimulation coils with different shapes can be obtained, so that the purpose of personalized stimulation is achieved.
10. The control method according to claim 9, wherein the display interface of the upper computer includes the following information:
displaying a tiled drawing of a triangular mesh personalized multi-coil transcranial magnetic stimulation array worn on a brain on one side of a display interface, and displaying a node control related menu on the other side, wherein the node control related menu comprises a node name selection frame, a gating direction selection, a gating confirmation key, a gating reset key, a pull-down direction selection, a pull-down confirmation key and a pull-down reset key; a node name selection frame is arranged in a node control related menu, each node has a name of the node, the node to be controlled can be selected in the node name selection frame through the name, and the corresponding node can be highlighted on a tiled image interface after the node is selected;
after the gating direction of the node is selected, gating is carried out on the corresponding direction of the node through a gating confirmation key, and if the gating information of the node needs to be reset, a gating reset key is pressed; if the node is used as a down-lead node, selecting the down-lead direction of the node, then down-leading the corresponding direction of the node through a down-lead confirmation key, and if down-lead information of the node needs to be reset, pressing down a down-lead reset key;
when a stimulation unit capable of stimulation has been formed in the array, the stimulation unit is highlighted at the corresponding location in the tile.
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