CN109620467A - A kind of nerve trachea formula Artificial neural and preparation method thereof - Google Patents
A kind of nerve trachea formula Artificial neural and preparation method thereof Download PDFInfo
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- CN109620467A CN109620467A CN201811434650.1A CN201811434650A CN109620467A CN 109620467 A CN109620467 A CN 109620467A CN 201811434650 A CN201811434650 A CN 201811434650A CN 109620467 A CN109620467 A CN 109620467A
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- 210000005036 nerve Anatomy 0.000 title claims abstract description 107
- 230000001537 neural effect Effects 0.000 title claims abstract description 31
- 210000003437 trachea Anatomy 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 230000004936 stimulating effect Effects 0.000 claims abstract description 48
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 9
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- 239000000463 material Substances 0.000 claims description 19
- 230000003321 amplification Effects 0.000 claims description 17
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 17
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- 239000012528 membrane Substances 0.000 claims description 9
- 230000015556 catabolic process Effects 0.000 claims description 8
- 238000006731 degradation reaction Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 229920001610 polycaprolactone Polymers 0.000 claims description 8
- 230000001052 transient effect Effects 0.000 claims description 8
- 229910001297 Zn alloy Inorganic materials 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 239000000956 alloy Substances 0.000 claims description 7
- 239000004632 polycaprolactone Substances 0.000 claims description 7
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- 239000012620 biological material Substances 0.000 abstract description 3
- 210000002569 neuron Anatomy 0.000 abstract description 3
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 abstract description 2
- 238000001727 in vivo Methods 0.000 description 7
- 208000010886 Peripheral nerve injury Diseases 0.000 description 4
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- 206010003694 Atrophy Diseases 0.000 description 1
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- 108010025020 Nerve Growth Factor Proteins 0.000 description 1
- 102000007072 Nerve Growth Factors Human genes 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/1128—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis of nerves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
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Abstract
The present invention relates to a kind of nerve trachea formula Artificial neurals and preparation method thereof, belong to technical field of biological materials.Artificial neural includes hollow conduit；Along the conduction orientation of nerve signal, it is equipped with acquisition annulus in the upstream end of hollow conduit, downstream is equipped with stimulating ring band；It is laid with acquisition electrode on the electrode arrangement face of acquisition annulus, is laid with stimulating electrode on the electrode arrangement face of stimulating ring band；Along conduction orientation, the signal processing circuit being electrically connected by conducting wire is laid between acquisition electrode and stimulating electrode, signal processing circuit includes the signal generation module for being analyzed acquisition electrode nerve signal collected and being generated analog neuron signal, with the signals revivification module for exporting the nerve signal by analog neuron signal through being reduced into stimulating electrode.Setting based on aforementioned structure while growing required microenvironment to provide for nerve, guarantees that nerve signal can normally conduct on defect nerve, can be widely applied in clinical treatment field.
Description
Technical field
The present invention relates to technical field of biological material, specifically, being related to a kind of nerve trachea formula Artificial neural and its preparation side
Method.
Background technique
It is limited to normally result in patient activity as a kind of frequently-occurring disease clinically for peripheral nerve injury, or even paralyses.
It currently, is mainly nerve suture and nerve-grafting for the treatment means of peripheral nerve injury；Wherein, nerve suture is commonly used in
Occasion of the neurologic defect length less than 2 centimetres, and when defect is more than 2 centimetres, in order to avoid excessive nerve tract internal tension, lead to
Frequently with the means of nerve-grafting；For nerve-grafting, it is commonly divided into nerve autograft and Allogeneic nerve graft, wherein
Nerve autograft is generally considered the goldstandard for the treatment of neurologic defect, however autologous nerve limited source, and often band
Carry out the missing that donor site feels different degrees of, therefore clinically can also use Allogeneic nerve graft sometimes, but the meeting again of this method
Immunological rejection is brought, new danger is caused.
With the development of organizational project and biomaterials art, the neural restoration of large quantities of such as nerve tracheas etc that have been born
Material；Wherein, nerve trachea is considered as a kind of more promising method for treating peripheral nerve injury, its basic function is
Defect nerve is bridged, and provides the growing environment with facilitation in pipe for nerve.This method can reduce neuroma
The eruption of formation, side shoot with scar, is conducive to the accumulation of neurotrophic factor, thus promote the growth of aixs cylinder with dock.
A kind of nerve with contact guiding function is disclosed in the patent document of Publication No. CN106236323A
Conduit, including hollow membrane tube body have the groove structure longitudinally extended on the inner wall of the hollow membrane tube body；It is by setting
The groove structure longitudinally extended along conduit is set, the contact area of pipe inner wall can not only be effectively improved, and can be improved and lead
The space utilization rate of tube cavity；In addition, in the patent document, also disclose it is a kind of using dry-wet imitative silk method manufacture it is aforementioned in
The method of empty tubular film is specially injected polymer solution and non-solvent (or other solution) outer with micro-injection pump respectively
In layer spray orifice and internal layer spray orifice, by the double-deck spray orifice extrusion molding, behind the air gap exported between coagulation basin through the double-deck spray orifice
Into in coagulation basin, after hollow membrane tube body dimensional stability, polymer nerve trachea sample is taken out from coagulation basin, by gained
Polymer nerve trachea sample is washed with deionized and removes after excess of solvent up to this nerve trachea.
However, perineural self-regeneration is a long process, 1 year or more continued treatment is generally required, at this
Period, injuring nerve are unable to maintain that normal physiological function, not only cause huge inconvenience to the life of patient, and can because
Long-term lacking movement causes defect section downstream limbs atrophy occur.
Summary of the invention
The main object of the present invention is to provide a kind of nerve trachea formula Artificial neural, can not only provide growth for defect nerve
Required environment also can provide the access of signal transduction for defect nerve；
It is a further object of the present invention to provide a kind of methods for manufacturing above-mentioned Artificial neural.
In order to achieve the above-mentioned main objectives, nerve trachea formula Artificial neural provided by the invention include by it is biocompatible can
Degradable material is made, and the hollow conduit with inner wall and outside wall surface；Hollow conduit, which has, to be limited by inner wall and is being indulged
The central lumen upwardly extended, for storing the bioactie agent that can promote nerve growth；Along the conduction orientation of nerve signal,
It is equipped with the acquisition annulus for acquiring the nerve signal that upstream side nerve segment is exported in the upstream end of hollow conduit, downstream is set
There is the stimulating ring band for stimulating downstream side nerve segment；Acquisition annulus includes acquisition annulus ontology and is arranged in inner wall surface thereof
Acquisition electrode, stimulating ring band include stimulating ring band body and the stimulating electrode that is arranged in inner wall surface thereof；In acquisition electrode and thorn
Swash the signal processing circuit for being laid between electrode and being electrically connected by conducting wire, extremely by acquisition electrode Neurotransmission collected
Stimulating electrode.
On basis by the hollow conduit for being capable of providing nerve growth environment in the prior art, pass through arranging signal
Acquisition electrode, conducting wire, signal processing circuit and stimulating electrode construct the conduction path of nerve signal, to realize that nerve signal exists
It is normally conducted between the both ends of neurologic defect section, the microenvironment for promoting growth is both provided for nerve, also can guarantee nerve
The normal conduction of signal has both timeliness and safety when treating peripheral nerve injury.
Specific scheme is the conduction orientation along nerve signal, and signal processing circuit includes the signal amplification mould sequentially arranged
Block and signals revivification module, signal amplification module are used for the nerve signal to the output of signals revivification module after its amplification, letter
Number recovery module is used to the amplitude of the nerve signal received being restored to preset value；The position of signals revivification module is laid in thorn
By the side for swashing electrode.By adding signal amplification circuit and signals revivification circuit, signal can be effectively prevented from hollow conduit
Long range conduction in conducting wire is distorted.
Another specific scheme is that annulus ontology is openable and closable flexible band body, the inner surface structure of flexible band body
At electrode arrangement face, electrode is attached on inner surface, and the part conducting line segment being electrically connected on electrode is attached on inner surface.
More specific scheme is that flexible band body is by base tube body through cutting out, and base tube body is using degradation material in
The matrix of empty catheter is made in a manner of integrally formed；Base tube body after cutting out, the end with part and hollow conduit
Affixed connected portion is kept, and from the portion of being connected along the circumferential span portion extended towards two sides of base tube body；The wall thickness in span portion is less than
The wall thickness of hollow conduit.Acquisition annulus, the matrix of hollow conduit and stimulating ring band are integral three sections of portions of structure, acquire annulus
With stimulating ring band have smaller wall thickness, and the two with gone out certain separation by cutting on the interface of nerve growth conduit
It region on the other hand can be according to the size by somatic nerves by annulus consequently facilitating nerve segment end is put into conduit in operation
It is seamed to corresponding size.
Further embodiment is that electrode circumferentially is attached on the inner surface of the base tube body after cutting out, and is soft
Property band-like film structure.
It adjacent to the section portion of electrode is the inner surface for being attached at flexible band body that further scheme, which is conducting wire, and with patch
Subsidiary formula formula is pasted to the flexible tape membrane structure on inner wall across extension behind connected portion.
Preferred scheme is that signal processing circuit is embedded in pipe wall body defined by inner wall and outside wall surface, and conducting wire includes
It water-tightly passes through inner wall and enters the flexible tape film section in pipe wall body.
Another preferred scheme is made of electrode and conducting wire of zinc alloy material；Signal processing circuit is using transient state electricity
Sub- device building；The matrix of annulus ontology and hollow conduit is prepared using polycaprolactone.
In order to achieve the above-mentioned another object, the present invention is provided to manufacture the method for nerve trachea formula Artificial neural include with
Lower step:
Using biocompatible degradation material, it is based on extrusion by melting, hollow conduit is prepared in a manner of integrally formed
Matrix and the base tube body that is connected on matrix both ends；Matrix, which has, to be limited by inner wall surface thereof and is in the longitudinal direction extended
Chambers of the heart room, central lumen is for storing the bioactie agent that can promote nerve growth；
Base tube body is cut out, to obtain the flexible band body that wall thickness is less than hollow conduit, flexible band body has portion
Divide and keep affixed connected portion with the end of matrix, and from the portion of being connected along the circumferential span portion extended towards two sides of base tube body；
Using zinc alloy material, signal processing circuit is constructed using microelectronic manufacturing technology, and in the outer wall surface side of matrix
Cut out accommodating chamber, the structural pipe wall that cuts out of original fill back in accommodating chamber, and use medical adhesive by signal processing circuit,
Conducting wire and backfill tube wall part are fixed in accommodating chamber, to be sealed；
The acquisition electrode of flexible tape film segment structure is attached to the inner surface of corresponding flexible band body with stimulating electrode
On, and arrange that flexible tape film segment structure along the circumferentially extending of base tube body, two end side of hollow conduit is arranged in construct
On acquisition annulus and stimulating ring band, and electrode is electrically connected with signal processing circuit using conducting wire；
Signal processing circuit and the conducting wire being connected electrically are sealed processing using medical adhesive.
Specific scheme is that signal processing circuit includes the signal amplification module sequentially arranged and signals revivification module, signal
Amplification module is exported to signals revivification module through the nerve signal after its amplification, and signals revivification module is used for defeated to stimulating electrode
Amplitude is through being restored to the nerve signal of preset value out；The step of being cut out to base tube body includes will be with using machining process
The tube wall skiving of the base tube body of matrix uniform thickness, then two are cut through skiving treated base tube body and constitutes C-shaped configuration, and will
Two C-shaped configurations and matrix junction circumferentially cut out the separated region of predetermined length from notch two sides towards middle section.
Detailed description of the invention
Fig. 1 is the schematic perspective view of Artificial neural's embodiment of the present invention；
Fig. 2 is the C partial enlarged view in Fig. 1；
Fig. 3 is the axial schematic cross-sectional view of Artificial neural's embodiment of the present invention；
Fig. 4 is the upward enlarged section of Artificial neural's embodiment of the present invention A-A shown in Fig. 3；
Fig. 5 is the enlarged section on Artificial neural's embodiment of the present invention B-B direction shown in Fig. 3；
Fig. 6 is Artificial neural's embodiment of the present invention in its schematic perspective view of span portion upon deployment；
Fig. 7 is the structural schematic diagram that Artificial neural's embodiment of the present invention is connect with defect nerve.
Specific embodiment
With reference to embodiments and its attached drawing the invention will be further described.
Artificial neural's embodiment
Referring to Fig. 1 to Fig. 7, nerve trachea formula Artificial neural 1 of the present invention includes hollow conduit 2, acquisition annulus 3, stimulating ring
With 4, connecting wire 6 and hermetically it is embedded in the intracorporal signal processing circuit 5 of tube wall of hollow conduit 2.
Hollow conduit 2 is the circular tube structure with inner wall 20 Yu outside wall surface 21；Inner wall surface thereof 20 is surrounded in open at both ends,
And the cylindrical center chamber 22 extended in the longitudinal direction, central lumen 22 for store can promote the bioactivity of nerve growth because
Son, with inner tubal wall 20 guide defect nerve the direction of growth, and by hollow conduit 2 addition trophic factors and it is disease-resistant because
The substances such as son promote the self-regeneration of defect nerve.
Acquisition annulus 3 includes the acquisition on acquisition annulus ontology 30 and the inner wall 300 for being arranged in acquisition annulus ontology 30
Electrode 31, annulus ontology 30 are openable and closable flexible band body, and the inner surface of flexible band body constitutes the cloth of acquisition electrode 31
Face is set, acquisition electrode 31 attaches in this interior surface.In the present embodiment, flexible band body be cut out by round shape base tube body and
At, and the base tube body use the bio-compatibles such as polycaprolactone and biological degradable in vivo material and hollow conduit 2 matrix with
Integrally formed mode is made, i.e. base tube body and the matrix of hollow conduit 2 is prepared simultaneously with same material；After cutting out
Base tube body, the end with part and hollow conduit 2 keeps affixed connected portion 305, and from the portion 305 that is connected along base tube body
, i.e., there is Separation in the circumferential span portion 301,302 extended towards two sides between span portion 301,302 and the end face of hollow conduit 2
303,304；In this embodiment, span portion 301 is identical as 302 structure size of span portion, and wall thickness is less than the wall of hollow conduit 2
It is thick.
Acquisition annulus ontology 30 on, base tube body of the acquisition electrode 31 before not cutting out circumferentially be attached to through
On the inner surface of base tube body after cutting out, specially flexible tape membrane structure, conducting wire 61 is adjacent to the section portion of acquisition electrode
For the inner surface for being attached at flexible band body, and across being pasted to hollow conduit 2 with extending behind connected portion 305 in a manner of attaching
Inner wall 20 on flexible tape membrane structure.
Stimulating ring band 4 includes stimulating ring band body 40 and the stimulation being arranged on the inner wall 400 of stimulating ring band body 40
Electrode 41, annulus ontology 40 are openable and closable flexible band body, and the inner surface of flexible band body constitutes the cloth of stimulating electrode 41
Face is set, stimulating electrode 41 attaches in this interior surface.In the present embodiment, flexible band body be cut out by round shape base tube body and
At, and the base tube body use the bio-compatibles such as polycaprolactone and biological degradable in vivo material and hollow conduit 2 matrix with
Integrally formed mode is made, i.e. base tube body and the matrix of hollow conduit 2 is prepared simultaneously with same material；After cutting out
Base tube body, the end with part and hollow conduit 2 keeps affixed connected portion 405, and from the portion 405 that is connected along base tube body
, i.e., there is Separation in the circumferential span portion 401,402 extended towards two sides between span portion 401,402 and the end face of hollow conduit 2
403,404；In this embodiment, span portion 401 is identical as 402 structure size of span portion, and wall thickness is less than the wall of hollow conduit 2
It is thick.
On stimulating ring band body 40, the base tube body before stimulating electrode 41 is not cut out circumferentially is attached to through cutting
On the inner surface of base tube body after sanction, specially flexible tape membrane structure, conducting wire 62 is adjacent to the section portion of stimulating electrode 41
For the inner surface for being attached at flexible band body, and across being pasted to hollow conduit 2 with extending behind connected portion 405 in a manner of attaching
Inner wall 20 on flexible tape membrane structure.
Wherein, for guide nerve growth hollow conduit 2 cross section be it is O-shaped, compared to the wall thickness of hollow conduit 2, adopt
The ontology for collecting annulus 3 and stimulating ring band 4 has smaller wall thickness, and the two is gone out on the interface of hollow conduit 2 by cutting
Certain separated region, thus on the one hand convenient for nerve is put into conduit in operation, it on the other hand can be according to by somatic nerves
Annulus is seamed to corresponding size by size.
Signal processing circuit 5 includes the signal amplification module 51 being sequentially electrically connected by conducting wire 6 and signals revivification module 52.
Signal generation module 51 is used to amplify the nerve signal collected of acquisition electrode 31 processing, and passes through conducting wire 65 to signal
Recovery module 52 exports the nerve signal after amplifying, the amplitude for the nerve signal that signals revivification unit 52 is used to receive
Be restored to preset threshold, i.e., the amplitude that signal transmits in neuron, and by the output to stimulating electrode 41 of conducting wire 6.To being adopted
The nerve signal of collection, which first amplifies, restores again processing, can be effectively prevented from it and pass over long distances on hollow conduit inside conductor
It leads and nerve signal distortion occurs.The function of signals revivification module 52 be near the terminal of conduction path to enhanced processing after
Nerve signal is restored, to guarantee the normal conduction of signal, position is preferably provided at by the side of stimulating electrode 41.
Signal processing circuit 5 is embedded in the pipe wall body as defined by the wall surface and outside wall surface of interior hollow conduit 2, specifically
To be hermetically embedded in entire processing circuit 5 and associated tracks 6 in pipe wall body using medical adhesive, conducting wire 6 includes water-tightly wearing
It crosses inner wall 20 and enters the flexible tape film section 63,64 in pipe wall body.To which the nerve collected of acquisition electrode 31 be believed
Number conduction is to signal amplification module 51, by the Neurotransmission after amplifying through signal amplification module 51 to signals revivification module
52, and by the Neurotransmission after being restored through signals revivification module 52 to stimulating electrode 41.I.e. along the conduction of nerve signal
Direction, acquisition annulus 3 are installed on the upstream end of hollow conduit 2, the nerve letter exported for acquiring upstream side nerve segment 01
Number, stimulating ring band 4 is installed on the downstream of hollow conduit 2, for stimulating downstream side nerve segment 02, to realize that nerve signal exists
The intranueral conduction of defect.
Along the transmission direction of nerve signal, acquisition electrode 31 is for acquiring upstream nerve signal, and stimulating electrode 41 is for piercing
Downstream neuronal is swashed, to realize nerve signal in the supraneural normal conduction of defect.In the present embodiment, the quantity of electrode and conducting wire
It is one.
The battery module by conducting wire for the power supply of each signal processing module is embedded in the pipe wall body of hollow conduit 2,
For providing required electric energy for the normal work of entire signal processing module 5.It of courses, is the clothes of extend as far as possible Artificial neural
Duration is used as a servant, is created conditions with the reparation for defect nerve, can arrange wireless charging module in the pipe wall body of hollow conduit 2, with
It charges for battery module.
In the present embodiment, conducting wire used in the conducting wire inside electrode and circuit and signal transduction is by bio-compatible, life
The material of object degradable in vivo manufactures, such as such as kirsite；Signal processing circuit, power supply module and wireless charging module are to adopt
It is constructed with bio-compatible and biological degradable in vivo electronic component, is constructed for example, by using transient state electronic device, in
The material of the base tube body of the matrix and annulus ontology of empty catheter 2 is all made of the material preparation of bio-compatible and biological degradable in vivo
It forming, such as selects polycaprolactone (PLC), PCL has good biocompatibility as a kind of hemicrystalline macromolecule,
Degradable in vivo to need 2-3, the time required to effectively ensuring that nerve growth, fusing point is 59-64 DEG C, is suitable for using molten
Melt and sends legal system and make conduit.
This Artificial neural embodiment is made using following methods, specifically includes the following steps:
(1) according to the size by somatic nerves, using biocompatible degradation material, such as polycaprolactone, based on melting
Extrusion molding, the base tube body that the matrix of hollow conduit 2 is prepared in a manner of integrally formed and is connected on matrix both ends；Matrix tool
There is the central lumen 22 for being limited by inner wall surface thereof and being extended in the longitudinal direction, which can promote nerve raw for storing
Long bioactie agent.
(2) base tube body is cut out, to obtain the flexible band body that wall thickness is less than hollow conduit 2, the flexibility band body
End with part and matrix keeps affixed connected portion 305 and connected portion 405, and from the portion of being connected along the circumferential court of base tube body
The span portion that two sides are extended.
Wherein, the step of being cut out to the base tube body includes using machining process by the base tube with matrix uniform thickness
The tube wall skiving of body, then two are cut through skiving treated base tube body and constitutes C-shaped configuration, and by two C-shaped configurations with
Matrix junction circumferentially cuts out the separated region of predetermined length from notch two sides towards middle section.
(3) transient state electronic device is utilized, signal processing circuit is constructed based on transient state electronic manufacturing technology, and in described matrix
Outer wall surface side cut out accommodating chamber, electrical connecting wire is constructed using zinc alloy material, the structural pipe wall that cuts out of original is filled
It returns in accommodating chamber, and signal processing circuit, conducting wire and the tube wall of backfill part is fixed on the accommodating chamber using medical adhesive
It is interior, to be sealed.
(4) use zinc alloy material, construct flexible tape film segment structure acquisition electrode and stimulating electrode, and by they
It is attached on the inner surface of corresponding flexible band body, and makes flexible tape film segment structure along the circumferentially extending cloth of the base tube body
It sets, to construct the acquisition annulus 3 being arranged on two end side of hollow conduit and stimulating ring band 4, and by electrode and is believed using conducting wire
The electrical connection of number processing circuit.
(5) signal processing circuit and the conducting wire being connected electrically are sealed processing using medical adhesive.
Used material is biocompatibility and degradation material in vivo, i.e., entire people to the present invention during manufacturing
It makes nerve and is all made of biocompatible degradation material and prepared, to avoid second operation.Around the present invention can be used for treating
Neurotrosis has good biocompatibility and degradability, and mind can be maintained while promoting nerve growth
Through the conduction function to signal, with good application prospect.
As shown in fig. 7, the present invention when bridging defect nerve, can be used perineurium sewing by defect nerve upper section 01
It is sutured with acquisition annulus 3, and defect nerve lower section 02 is sutured with stimulating ring band 4；In addition, it is necessary to according to the size by somatic nerves
Suture ring band is bonded acquisition electrode 31, stimulating electrode 41 with nerve surface, to acquire nerve signal or stimulate the nerve segment.
To both provide growth required microenvironment for nerve, the normal conduction of nerve signal also can guarantee, around treatment
Timeliness and safety are had both when neurotrosis.Electrode signal acquisition can capture the signal that neurologic defect section upstream is transmitted, and
Via conducting wire input signal processing circuit, it is able to carry out length after amplifying and avoids being distorted away from conduction, finally recycles letter
The amplitude of nerve signal is restored to preset value by number recovery module, and ensures the normal conduction of nerve signal.
In the above-described embodiments, circuit part is transient circuit, is related to radio-frequency module, power module, amplification circuit module
With reduction circuit module, specific element includes antenna, rectifier diode, transistor, capacitor, inductance, resistance, ring oscillator electricity
Source and RF energy collection module, all subcomponents are all by having the material system of degradability in biocompatibility and organism
It makes, such as the silicon materials such as monocrystalline silicon or polysilicon, magnesium, magnesia, dielectric and fibroin etc..
Preparation method embodiment
In the explanation of above-mentioned Artificial neural's embodiment, preparation method embodiment of the present invention is illustrated, herein
It repeats no more.
The main idea of the present invention is by that can provide existing for the reparation of defect nerve in growth microenvironment
Acquisition electrode, signal processing circuit and the stimulation circuit being electrically connected by conducting wire are arranged in empty catheter, to be given birth in defect nerve
During long reparation, the conduction that nerve signal is provided between two sections of defects nerves provides access.It is hollow to lead according to this design
Pipe, the specific structure for acquiring annulus, stimulating ring band, electrode, conducting wire and processing circuit also change there are many obvious, not
It is confined to above-described embodiment.
Claims (10)
1. a kind of nerve trachea formula Artificial neural, including be made of biocompatible degradation material, and with inner wall and outside
The hollow conduit of wall surface；The hollow conduit has the central lumen for being limited by the inner wall and being extended in the longitudinal direction, uses
It can promote the bioactie agent of nerve growth in storage；
It is characterized by:
Along the conduction orientation of nerve signal, it is equipped in the upstream end of the hollow conduit and is exported for acquiring upstream side nerve segment
Nerve signal acquisition annulus, downstream is equipped with stimulating ring band for stimulating downstream side nerve segment；The acquisition annulus packet
The acquisition electrode for including acquisition annulus ontology and being arranged in inner wall surface thereof, the stimulating ring band includes stimulating ring band body and arrangement
Stimulating electrode in inner wall surface thereof；
The signal processing circuit being electrically connected by conducting wire is laid between the acquisition electrode and the stimulating electrode, it will be described
Acquisition electrode Neurotransmission collected is to the stimulating electrode.
2. Artificial neural according to claim 1, it is characterised in that:
Along the conduction orientation, the signal processing circuit includes the signal amplification module sequentially arranged and signals revivification module,
The signal amplification module is used for the nerve signal to signals revivification module output after its amplification, the signals revivification
Module is used to the amplitude of the nerve signal received being restored to preset value；
The position of the signals revivification module is laid in position by the side of the stimulating electrode.
3. Artificial neural according to claim 1, it is characterised in that:
Annulus ontology is openable and closable flexible band body, and the inner surface of the flexibility band body constitutes the placement-face of electrode, electricity
Pole attaches on the internal surface, and the part conducting line segment being electrically connected on electrode is attached on the inner surface.
4. Artificial neural according to claim 3, it is characterised in that:
It is described flexibility band body be by base tube body through cutting out, the base tube body using the degradation material with it is described hollow
The matrix of conduit is made in a manner of integrally formed；The base tube body after cutting out has part and the hollow conduit
End keep affixed connected portion, and from the connected portion along the circumferential span portion extended towards two sides of the base tube body；
The wall thickness in the span portion is less than the wall thickness of the hollow conduit.
5. Artificial neural according to claim 4, it is characterised in that:
Electrode circumferentially is attached on the inner surface of the base tube body after cutting out along described, is flexible tape film
Structure.
6. Artificial neural according to claim 5, it is characterised in that:
Conducting wire is the inner surface for being attached at the flexible band body adjacent to the section portion of electrode, and across described solid in a manner of attaching
The flexible tape membrane structure being pasted to extending behind portion, company on the inner wall of the hollow conduit.
7. according to claim 1 to Artificial neural described in any one of 6 claims, it is characterised in that:
The signal processing circuit is embedded in the inner wall of the hollow conduit in pipe wall body defined by the outside wall surface, leads
Line includes water-tightly passing through the inner wall of the hollow conduit and entering the intracorporal flexible tape film section of the tube wall.
8. according to claim 1 to Artificial neural described in any one of 6 claims, it is characterised in that:
Electrode and conducting wire are made of zinc alloy material；
Signal processing circuit is constructed using transient state electronic device；
The matrix of annulus ontology and hollow conduit is prepared using polycaprolactone.
9. a kind of method for manufacturing nerve trachea formula Artificial neural, which comprises the following steps:
Using biocompatible degradation material, it is based on extrusion by melting, the base of hollow conduit is prepared in a manner of integrally formed
Body and the base tube body being connected on the both ends of described matrix；Described matrix, which has, to be limited by inner wall surface thereof and is prolonged in the longitudinal direction
The central lumen stretched, the central lumen is for storing the bioactie agent that can promote nerve growth；
The base tube body is cut out, to obtain the flexible band body that wall thickness is less than the hollow conduit, the flexible-belt sheet
There is body the end of part and described matrix to keep affixed connected portion, and from the connected portion along the circumferential court of the base tube body
The span portion that two sides are extended；
Using transient state electronic device, signal processing circuit is constructed based on transient state electronic manufacturing technology, and in the outer wall of described matrix
Surface side cuts out accommodating chamber, constructs electrical connecting wire using zinc alloy material, and the structural pipe wall that original is cut out is filled back receiving
In chamber, and the signal processing circuit, conducting wire and backfill tube wall part are fixed in the accommodating chamber using medical adhesive；
Using zinc alloy material, the acquisition electrode and stimulating electrode of flexible tape film segment structure are constructed, and they are attached to
On the inner surface of corresponding flexibility band body, and arrange that flexible tape film segment structure along the circumferentially extending of the base tube body, with
The acquisition annulus and stimulating ring band being arranged on two end side of hollow conduit are constructed, and utilizes the conducting wire by electrode and the letter
The electrical connection of number processing circuit；
The signal processing circuit and the conducting wire being connected electrically are sealed processing using medical adhesive.
10. according to the method described in claim 9, it is characterized by:
The signal processing circuit includes the signal amplification module sequentially arranged and signals revivification module, the signal amplification module
To nerve signal of the signals revivification module output after its amplification, the signals revivification module is used for the stimulation electricity
Pole output amplitude is through being restored to the nerve signal of preset value；
The described the step of base tube body is cut out include using machining process by with described in described matrix uniform thickness
The tube wall skiving of base tube body, then two are cut through skiving treated base tube body and constitutes C-shaped configuration, and by two C-shaped knots
Structure and described matrix junction circumferentially cut out the separated region of predetermined length from notch two sides towards middle section.
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| CN201811434650.1A CN109620467B (en) | 2018-11-28 | 2018-11-28 | Nerve conduit type artificial nerve and preparation method thereof |
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| CN109620467B (en) | 2020-03-03 |
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