CN109908467A - Nerve electric stimulation electrode assembly and preparation method thereof - Google Patents
Nerve electric stimulation electrode assembly and preparation method thereof Download PDFInfo
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- CN109908467A CN109908467A CN201910339477.5A CN201910339477A CN109908467A CN 109908467 A CN109908467 A CN 109908467A CN 201910339477 A CN201910339477 A CN 201910339477A CN 109908467 A CN109908467 A CN 109908467A
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- Electrotherapy Devices (AREA)
Abstract
This application involves a kind of nerve electric stimulation electrode assemblies and preparation method thereof.The nerve electric stimulation electrode assembly includes soluble glue, electrode catheter and puncture tube.The electrode catheter includes protection pipe and the first fixing piece including the first fixed part and the first fixed-wing.First fixed part fixing sleeve is set to protection pipe.First fixed-wing includes the first fixing end and the first free end.First fixing end is connect with one end of first fixed part.First free end invests the protection pipe by the soluble gluing.Puncture tube is sheathed on the electrode catheter.After the electrode catheter is implanted into destination organization and reaches target spot, solubility is glued contact liquid and is gradually dissolved, and loses viscosity, so that the first free end is opened automatically, is embedded into destination organization, realizes the fixation of electrode catheter and destination organization.It without using the fixed fixing piece of pipe sleeve, thus solves since frictional force is larger between casing and electrode catheter fixed structure, the problem of great inconvenience is caused to surgical operation.
Description
Technical field
This application involves medical instruments fields, more particularly to a kind of nerve electric stimulation electrode assembly and preparation method thereof.
Background technique
Stimulation system is a kind of active implantable medical devices.With widely used cardiac pacemaker system class
Seemingly, stimulation system is also made of the electrode catheter of the impulse generator of generation stimulus signal and transmitting stimulus signal.It will
Electrode catheter is implanted into the patient, and the signal that impulse generator generates passes through electrode catheter stimulation target nerve or nerve nucleus,
Regulate and control nerve by way of electro photoluminescence to achieve the purpose that treatment or improve disease symptoms.To obtain treatment steady in a long-term
Effect, it is necessary to keep stimulation contact on electrode catheter and target position constant.Therefore, it when electrode catheter is implanted into, should take
Electrode catheter and tissue are fixed effective measures.In other words, whether permanent neurologic electro photoluminescence implant surgery succeeds,
Can the electrode catheter depending on implantation be securely positioned at target position without movement.
Currently, in the neural stimulation system for carrying out electrode implantation using Percutaneous Techniques, such as implanted sacral nerve
Electric stimulation, implanted spinal cord stimulation trial system, implanted dorsal root ganglion stimulating system etc., electrode catheter passes through itself
The fixed structure having, which is realized, to be fixed.After electrode catheter is implanted to human body by puncturing operation, the fixed structure of its own is embedded in
Into tissue, to realize the fixation to electrode catheter position.Such as patent application US20030045919A1,
The relevant apparatus mentioned in CN105056397A, US20040230279A1.The electrode catheter fixed structure mentioned in above-mentioned patent
For reversed acanthoid structure.For that need to be compressed with casing to reversed acanthoid fixed structure, in electrode convenient for the implantation of the puncturing operation of electrode catheter
After conduit implants and reaches target position, then casing taken out outside the reversed acanthoid fixed structure of electrode catheter.Due to
Frictional force is larger between casing and fixed structure, causes great inconvenience to surgical operation.
Summary of the invention
Based on this, it is necessary to be directed to since frictional force is larger between casing and electrode catheter fixed structure, give surgical
Operation causes the problem of great inconvenience, provides a kind of nerve electric stimulation electrode assembly and preparation method thereof.
Nerve electric stimulation electrode assembly provided by the present application includes soluble glue, electrode catheter and puncture tube.The electrode
Conduit includes protection pipe and the first fixing piece.The protection pipe has the connecting pin and stimulated side being oppositely arranged, the connecting pin
For connecting with impulse generator, the stimulated side is for stimulating target spot.First fixing piece includes the first fixed part and the
One fixed-wing.The first fixed part fixing sleeve is set to the protection pipe.First fixed-wing includes the first fixing end and the
One free end.First fixing end is connect with one end of first fixed part.First free end can be by described
Soluble gluing invests the protection pipe.The puncture tube is sheathed on the electrode catheter, for assisting the electrode catheter to plant
Enter to target spot.
First free end is adhered to the protection pipe by soluble glue by above-mentioned nerve electric stimulation component, so that institute
First fixing piece for stating electrode catheter is fixed on the protection pipe.When the electrode catheter is implanted into destination organization and reaches target
After point, the solubility is glued contact liquid and is gradually dissolved, and loses viscosity, so that first free end is opened automatically, insertion
To the destination organization, the fixation of the electrode catheter Yu the destination organization is realized.Without using the fixed fixation of pipe sleeve
The free end of part, thus solve since frictional force is larger between casing and electrode catheter fixed structure, give surgical operation
Cause the problem of great inconvenience.
Detailed description of the invention
Fig. 1 is the structure chart for the nerve electric stimulation electrode assembly electrode catheter that one embodiment of the application provides；
Fig. 2 provides the figure of the structure of nerve electric stimulation electrode assembly electrode catheter for another embodiment of the application；
Fig. 3 is the enlarged diagram of the first fixed part that one embodiment of the application provides and soluble glue；
Fig. 4 is the amplification enlarged drawing of the first fixed part that another embodiment of the application provides and soluble glue；
Fig. 5 is the nerve electrode component preparation method flow chart that one embodiment of the application provides；
Fig. 6 is the nerve electrode component implantation process schematic diagram that one embodiment of the application provides；
Fig. 7 is the nerve electrode component method for implantation flow chart that one embodiment of the application provides.
Drawing reference numeral explanation:
Nerve electric stimulation electrode assembly 10, electrode catheter 100, protection pipe 110, connecting pin 113, stimulated side 115, connection touching
Point 114 stimulates contact 116, and target label 117, handhold element 119, the first fixing piece 120, the first fixed part 121, first is solid
Determine the wing 122, the first fixing end 1221, the first free end 1222, X-ray developing mark 123, fixinig plate 124, the second fixing piece 130,
Second fixed part 131, the second fixed-wing 132, the second fixing end 1321, the second free end 1322, the first fixed area 125, second
Fixed area 126, soluble glue 140, puncture tube 200, destination organization 300, target spot 310, nerve electric stimulation device 40, pulse generation
Device 410.
Specific embodiment
Referring to FIG. 1, nerve electric stimulation electrode assembly 10 provided by the present application includes soluble glue 140, electrode catheter 100
With puncture tube 200.The electrode catheter 100 includes protection pipe 110 and the first fixing piece 120.The protection pipe 110 has opposite
The connecting pin 113 and stimulated side 115 of setting, for connecting with impulse generator, the stimulated side 115 is used for the connecting pin 113
In stimulation target spot.First fixing piece 120 includes the first fixed part 121 and the first fixed-wing 122.First fixed part
121 fixing sleeves are set to the protection pipe 110.First fixed-wing 122 includes the first fixing end 1221 and the first free end
1222.First fixing end 1221 is connect with one end of first fixed part 121.First free end 1222 can lead to
It crosses the soluble glue 140 and is adhered to the protection pipe 110.The puncture tube 200 is sheathed on the electrode catheter 100, is used for
The electrode catheter 100 is assisted to be implanted to target spot.It should be understood that the puncture tube 200 is hollow structure.And the puncture tube 200
Internal diameter be greater than the electrode catheter 100 outer diameter, in order to which the puncture tube 200 is sheathed on the electrode catheter 100.
First free end 1222 is adhered to described by above-mentioned nerve electric stimulation electrode assembly 10 by soluble glue 140
Protection pipe 110, so that first fixing piece 120 of the electrode catheter 100 is fixed on the protection pipe 110.When the electricity
After pole conduit 100 is implanted into destination organization and reaches target spot, the solubility glue 140 contacts body fluid and gradually dissolves, and loses viscosity,
So that first free end 1222 is opened automatically, it is embedded into the destination organization, realizes the electrode catheter 100 and the mesh
Mark the fixation of tissue.Without using the free end of the fixed fixing piece of pipe sleeve, thus solve due to casing and electrode catheter
Frictional force is larger between 100 fixed structures, and the problem of great inconvenience is caused to surgical operation.
In one embodiment, the protection pipe 110 is the cannula structure body of interior sky, and encirclement forms inner cavity.The stimulation
End 115 is closing structure, and the head of the stimulated side 115 can be smooth curved surface, is conducive to be implanted into destination organization, stimulates target
Point.The connecting pin 113 is hatch frame, in order to which inside insertion steel wire facilitates surgical procedure.
In one embodiment, the connecting pin 113 includes multiple connecting terminals 114, and the stimulated side 115 includes multiple
Stimulate contact 116, the connecting terminal 114 is equal with the stimulation quantity of contact 116, the connecting terminal 114 with it is described
It stimulates contact 116 to correspond by conducting wire to be electrically connected.
In the above-described embodiments, the multiple connecting terminal 114 is for receiving different pulse signals from impulse generator
Or pulse signal in different time periods.The received pulse signal of the multiple connecting terminal 114 is transmitted to by different conducting wires
The different stimulation contacts 116 conveys different pulse signal or pulse signal in different time periods to target spot to realize, reaches
To therapeutic effect.It should be understood that between the adjacent connecting terminal 114, it is electrical each other between the adjacent stimulation contact 116
Isolation.
In one embodiment, the connecting terminal 114 can be ring structure body, be embedded in the protection pipe 110.Institute
Stating connecting terminal 114 can be made of the conductive material with biocompatibility, such as stainless steel, cobalt alloy, titanium, titanium close
Gold, tantalum, platinumiridio etc..In another embodiment, the stimulation contact 116 can be ring structure body.The stimulation touching
Point 116 can be electrically connected by way of resistance spot welding or laser spot welding with the conducting wire.The stimulation contact 116 can be by leading
The material composition with biocompatibility of electricity, such as platinum or platinumiridio or surface are coated with platinum or platinumiridio coating
Material.
In one embodiment, the conducting wire runs through the inner cavity of the entire protection pipe 110.The conducting wire can be
More helixes or twisted wire, and mutually insulated.Each wire both ends respectively with a connecting terminal 114 and a stimulation contact
116 link together.The conducting wire can pass the electric impulse signal that the connecting pin 113 is received from the impulse generator
It is sent to the stimulated side 115.
In one embodiment, in a free state (no external force apply state), described the of first fixed-wing 122
One free end 1222 is tilted towards the direction far from the protection pipe 110 opens, and surrounds and forms an opening.It should be understood that being opened when described
When mouthful direction is towards the connecting pin 113, towards the company after the electrode catheter 100 can be prevented to be implanted into the destination organization
It is mobile to connect end 113.When the opening direction is towards the stimulated side 115, the electrode catheter 100 can be prevented to be implanted into described
It is mobile towards the stimulated side 115 after destination organization.First fixing piece 120 has unidirectional shrinkage, under stress,
First free end 1222 of first fixed-wing 122 can be compressed completely, fit in the protection pipe 110.Deng
It is free by described first by the soluble glue 140 after being fitted in the protection pipe 110 to first free end 1222
End 1222 is adhered to the protection pipe 110, then removes external force.It is described solvable after the electrode catheter 100 is implanted into destination organization
Property glue 140 encounter body fluid and decompose and lose viscosity, first free end 1222 tilts automatically opens, and is embedded into the target group
In knitting, fixed function is played to the electrode catheter 100.Without using fixed first free end 1222 of pipe sleeve, thus solve
It has determined since frictional force is larger between 100 fixed structure of casing and electrode catheter, has caused great inconvenience to surgical operation
The problem of.
In one embodiment, the material that the material of first fixing piece 120 can be good for shrinkage, such as poly- ammonia
Ester, silicon rubber or polyurethane-silastic polymer.In the above-described embodiments, described that first fixed part 121 is sheathed on the guarantor
It on pillar 110, and can be fixed with the mode of bonding or welding, then by 120 He of the first fixing piece of the electrode catheter 100
The drying completely of protection pipe 110.
Fig. 2 is referred to, the protection pipe 110 further includes at least one second fixing piece 130 in one embodiment.Each
Second fixing piece 130 includes the second fixed part 131 and two the second fixed-wings 132.Second fixed part, 131 fixing sleeve
Set on the protection pipe 110.Described two fixed-wings are respectively arranged at the opposite both ends of second fixed part 131.Each institute
Stating the second fixed-wing 132 includes the second fixing end 1321 and the second free end 1322.Second fixing end 1321 is set to institute
State the second fixed part 131.Second free end 1322 can be adhered to the protection pipe 110 by the soluble glue 140.
(no external force applies state) in a free state, each second free end 1322 is directed away from the protection pipe 110
Direction tilt open, surround formed one opening.The opening direction that one of them described second free end 1322 is formed is towards institute
The connecting pin 113 of protection pipe 110 is stated, the opening direction that another described second free end 1322 is formed is towards the protection
The stimulated side 115 of pipe 110.Under stress, described two second free ends 1322 are shunk, and fit in the guarantor respectively
Pillar 110.Described two second free ends 1322 are adhered to by the protection pipe 110 by the soluble glue 140 respectively again,
Until after the solubility glue 140 is fully cured, then the external force of application is removed, so that described two second free ends 1322 pass through
The solubility glue 140 is adhered to the protection pipe 110.After the electrode catheter 100 is implanted into the destination organization, it is described can
Soluble gum 140 contacts body fluid, gradually dissolves and loses viscosity, two second free ends 1322 are respectively facing the stimulated side
115 and the connecting pin 113 open, the destination organization is embedded in, so that the electrode catheter 100 is fixed on the target group
It knits.Described two free ends are in the opposite direction, it can prevent the electrode catheter 100 from moving towards the connecting pin 113
It is dynamic, the electrode catheter 100 is also possible to prevent towards the stimulated side 115 movement, has further fixed the electrode catheter 100
Position in the destination organization.
In one embodiment, the protection pipe 110 includes two first fixing pieces 120.First fixing piece
120 are respectively arranged at the two sides of second fixing piece 130, and the direction of two first free ends 1222 is opposite.At this
In embodiment, described two first free ends 1222 are in the opposite direction, it can prevent the electrode catheter 100 towards institute
It is mobile to state connecting pin 113, is also possible to prevent the electrode catheter 100 towards the stimulated side 115 movement, has further fixed institute
State position of the electrode catheter 100 in the destination organization.Fig. 2 is referred to, in one embodiment, the protection pipe 110 is wrapped
Include two first fixing pieces 120 and second fixing piece 130.The court of one of them first free end 1222
To with the second free end 1322 described in one of them towards identical, the direction of another first free end 1222 with it is another
A second free end 1322 towards identical.This setup can further strengthen the fixed electrode catheter 100
Position in the destination organization prevents the electrode catheter 100 from moving towards the stimulated side 115 or the connecting pin 113
It is dynamic.
In one embodiment, the protection pipe 110 includes multiple first fixing pieces 120.Along the protection pipe 110
Axis direction, the direction of at least one first free end 1222 and the first free end 1222 described in other are towards phase
Instead.
Referring again to Fig. 1, in one embodiment, the protection pipe 110 is divided for the first fixed area 125 and the second fixed area
126.The quantity for first fixing piece 120 that first fixed area 125 and second fixed area 126 are arranged is identical.Position
First free end 1222 in first fixed area 125 and described first positioned at second fixed area 126 are free
The direction at end 1222 is opposite.In one embodiment, first fixed area 125 is close to the connecting pin 113, is located at described the
First free end 1222 of first fixing piece 120 of one fixed area 125 is being located at institute towards the stimulated side 115
After first free end 1222 opening for stating the first fixed area 125, it is embedded in destination organization, the electrode catheter can be prevented
100 is mobile towards the stimulated side 115.It is fixed to be located at described second close to the stimulated side 115 for second fixed area 126
First free end 1222 of first fixing piece 120 in area 126 is being located at described second towards the connecting pin 113
After first free end 1222 of fixed area 126 is opened, it is embedded in destination organization, 100 court of electrode catheter can be prevented
It is mobile to the connecting pin 113.The 120 quantity phase of the first fixing piece of first fixed area 125 and second fixed area 126
Together, can make after first free end 1222 opens and is embedded in destination organization, the stress of the electrode catheter 100 is equal
It is even, prevent it mobile towards both ends, so that fixed effect is more preferable.
Fig. 3 is referred to, in one embodiment, first fixed-wing 122 includes multiple fixinig plates 124, the multiple
Fixinig plate 124 is around the setting of first fixed part 121 interval.The multiple institutes being uniformly arranged around first fixed part 121
Destination organization can be embedded in order to first fixed-wing 122 by stating fixinig plate 124, not easily to fall off.And multiple fixations
The structure of piece 124, which can increase, can stick together area, adhere to first fixed-wing 122 and described convenient for the soluble glue 140
Protection pipe 110.
In one embodiment, the multiple fixinig plate 124 fits in the protection pipe 110,140 points of the glue of solubility
It is applied to the edge of the fixinig plate 124.In another embodiment, the soluble glue 140, which can be put, is applied to the fixinig plate 124
Edge and the protection pipe 110.140 points of the glue of solubility is applied to the edge of the fixinig plate 124, leads convenient for the electrode
After pipe 100 is implanted into destination organization, the solubility glue 140 is contacted with body fluid, increases connecing for solubility glue 140 and the body fluid
Contacting surface product, opens as early as possible convenient for first free end 1222, is embedded in the destination organization.
Fig. 4 is referred to, in one embodiment, the solubility glue 140 is coated on outside first fixed-wing 122,
One layer of film for surrounding first fixed-wing 122 is formed, first free end 1222 is adhered to by the soluble glue 140
In the protection pipe 110.In another embodiment, the soluble glue 140 surrounds the fixinig plate 124 with two neighboring fixation
Gap between piece 124 forms layer protecting film.The package area that the soluble glue 140 can be increased, leads in the electrode
After pipe 100 is implanted into the destination organization, the contact area of the soluble glue 140 and body fluid is increased, thus can described in accelerating
The solution rate of soluble gum 140 accelerates the electrode catheter 100 in the target so that the fixinig plate 124 is easier to open
Fixation in tissue.Referring again to Fig. 1, in one embodiment, the electrode catheter 100 further includes target label 117, setting
Between the connecting pin 113 and first fixing piece 120；The end pair of the target label 117 and the puncture tube 200
The stimulated side 115 of Qi Shi, the electrode catheter 100 reach target spot.
In the above-described embodiments, when the target label 117 is implanted into for the electrode catheter 100 to paracentesis depth
Monitoring.The target label 117 can be sheathed in the protection pipe 110 etch, brush, paste, fixing sleeve setting tool have it is bright
The color or structure of aobvious distinction.For example, white stripes can be brushed in the protection pipe 110 or paste white ribbon etc..
During the electrode catheter 100 is implanted into the destination organization, the puncture tube 200 is inserted into the destination organization, described
The piercing end of puncture tube 200 is located at target position.The other end of the puncture tube 200 is exposed to outside the destination organization.Again will
The electrode catheter 100 is inserted into the puncture tube 200, when the target label 117 and the puncture tube 200 of the protection pipe 110
The end part aligning being located at outside the destination organization when, the stimulated side 115 of the electrode catheter 100 reaches target spot, therefore is convenient for
Real-time monitoring paracentesis depth, it is ensured that the stimulated side 115 of the electrode catheter 100 reaches the target spot, to reach therapeutic effect.
In one embodiment, the electrode catheter 100 further includes two X-ray developing marks 123, is respectively arranged at described
The starting position of fixing piece and terminated site, for positioning first fixing piece 120.The X-ray developing mark 123 is used for institute
State the position for determining first fixing piece 120 after electrode catheter 100 is implanted under x-ray.The X-ray developing mark 123
By to the biggish material production of X-ray absorption decaying, such as tantalum, platinum, platinumiridio or baric, tungstenic, the polymer of bismuth-containing etc..
In one embodiment, the electrode catheter 100 further includes handhold element 119, and the handhold element 119 is set to
The connecting pin 113 is implanted into the electrode catheter 100 for assisting.The connecting pin 113 of the protection pipe 110 is hatch frame,
The handhold element 119 can be inserted in the opening.The handhold element 119 is used to enhance the rigidity of electrode, convenient for described
Electrode catheter 100 is implanted into the destination organization, is convenient for surgical procedure.After the electrode catheter 100 is implanted into the destination organization,
The handhold element 119 can be taken out from the electrode catheter 100, be detached from the electrode catheter 100.
In one embodiment, the material of the soluble glue 140 is starch, dextrin, cellulose, polyvinylpyrrolidone
Or N vinylamide polymer.Above-mentioned material has dissolvable or degradable in vivo, good biocompatibility, water solubility in vivo
The characteristic of polymer, when destination organization contacts one section with body fluid after, can gradually dissolve or decompose and lose viscosity, so that institute
It states the first free end 1222 or second free end 1322 to be fully deployed, be embedded into destination organization, realize that the electrode is led
The fixation of pipe 100 and the destination organization.
In one embodiment, the soluble glue 140 can be polyvinylpyrrolidonesolution solution (PVP).Polyethylene pyrrole
Pyrrolidone solution (PVP) has excellent solubility property and physiological compatibility, and molecular weight K value is bigger, and viscosity is bigger, cementability
Stronger, rate of dissolution is slower.The polyvinylpyrrolidone K value used in one embodiment is 90.By polyvinylpyrrolidone
Solution can successively be put on the side (edge) and the protection pipe 110 for being coated in each fixinig plate 124, complete to PVP
After solidification, the external force of application is removed, the fixinig plate 124 is sticked together with the protection pipe 110.
In one embodiment, the material of the protection pipe 110 is polyurethane, silicon rubber or polyurethane-silicon rubber polymerization
Object.The material of the fixing piece may be polyurethane, silicon rubber or polyurethane-silastic polymer.The polyurethane, silicon rubber
Glue or polyurethane-silastic polymer material and the soluble glue 140 have it is good glue stickiness, be convenient for the fixed-wing
Free end the protection pipe 110 is adhered to by the soluble glue 140.
In one embodiment, the usage amount of the soluble glue 140 should ensure that first fixed-wing 122 or described the
Two fixed-wings 132 can compress completely, fit in the protection pipe 110.And the electrode catheter 100 is being implanted to target
After tissue, the solubility glue 140 loses viscosity, and first fixed-wing 122 or second fixed-wing 132 open institute completely
It takes time and is less than 12h.
Fig. 5 is referred to, present invention also provides a kind of preparation methods 20 of nerve electric stimulation electrode assembly 10.The preparation
Method 20 the following steps are included:
First fixed part 121 of first fixing piece 120 is sheathed on and is fixed on the protection pipe 110 by S210；
S220 applies external force to the first fixed-wing 122 of first fixing piece 120, pastes first free end 1222
Together in the protection pipe 110；
S230 applies the soluble glue 140 between first free end 1222 and the protection pipe 110；
After the solidification of solubility glue 140 described in S240, the external force of application is removed, so that first free end 1222 fits in
The protection pipe 110.
In one embodiment, the step S210 specifically includes fixed by described the first of first fixing piece 120
Portion 121 is sheathed in the protection pipe 110, with heat gun under conditions of 150 DEG C, by first fixed part 121 and described
The hot melt of protection pipe 110 is fixed together.Then by first fixing piece 120 and the protection pipe 110 in alcohol or isopropanol
Solvent in ultrasonic cleaning (or plasma cleaning), the impurity on surface and greasy dirt are cleaned up.After cleaning up, air blast is used
Drying box dries first fixing piece 120 and the protection pipe 110 completely.Then implement the step S220 to described
First free end 1222 of one fixed-wing 122 applies external force, makes the compression completely of the first free end 1222, fits in guarantor
On pillar 110.The soluble glue 140 used in the step S230 can be polyvinylpyrrolidonesolution solution (PVP),
It is with excellent solubility property and physiological compatibility, and molecular weight K value is bigger, and viscosity is bigger, and cementability is stronger, rate of dissolution
Slower, the polyvinylpyrrolidone K value that the present embodiment uses is 90.Polyvinylpyrrolidonesolution solution is successively put and is coated in each institute
On the side and the protection pipe 110 for stating the first free end 1222, after PVP is fully cured, the external force of application is removed, described
One fixed-wing 122 is sticked together with the protection pipe 110.
It should be understood that the first fixing piece 120 described herein and second fixing piece 130 are that function is identical, material phase
With the only different structure of function, therefore, by second fixing piece 130 be fixed on the mode of the protection pipe 110 with will be described
The mode that first fixing piece 120 is fixed on the protection pipe 110 is identical.Use the soluble glue 140 make described second from
The operating process of the protection pipe 110 are adhered to by end 1322 and the soluble glue 140 is used to make described the with free end
1222 be adhered to the protection pipe 110 operating process it is identical, do not repeat them here.
Fig. 6 and Fig. 7 are referred to, present invention also provides a kind of method for implantation 30 of nerve electric stimulation electrode assembly.It is described
Method for implantation 30 the following steps are included:
Puncture tube 200 is inserted into destination organization 300 by S310, and the piercing end of puncture tube 200 is made to be located at target position
310；
Electrode catheter 100 is inserted into the puncture tube 200 by S320, so that the stimulated side 115 of the electrode catheter 100 is located at
The target position；
S330 extracts the puncture tube 200；
S340 is after soluble glue 140 loses viscosity, and the first fixed-wing 122 of the first fixing piece 120 opens automatically, insertion
Into the destination organization 300.
In one embodiment, the method for implantation 30 can also include that step S350 passes through X-ray after step S340
Development detects the position of first fixing piece 120, in order to monitor first fixing piece 120 in the destination organization 300
In position.
In one embodiment, the step S310, which is specifically included, is put into destination organization 300 for the puncture needle with groove
Middle searching target spot position 310, the groove of puncture needle exposes to the destination organization 300 at this time.Then along the puncture needle by institute
It states puncture tube 200 to be inserted into the destination organization 300, so that the puncture tube 200 exposes to one end of the destination organization 300
It is aligned with the groove of the puncture needle, the piercing end of the puncture tube 200 is located at target position 310 at this time.Again by the puncture
Needle, which is extracted and executes the step S320, is inserted into the puncture tube 200 for the electrode catheter 100, so that the electrode catheter
100 stimulated side 115 is located at the target position 310, i.e., the target label 117 of the described electrode catheter 100 is worn with described
Thorn pipe 200 exposes to one end alignment of the destination organization 300.It should be understood that institute in the electrode catheter 100 in step S320
First free end 1222 for stating the first fixed-wing 122 is in compressive state, fits in the protection pipe 110.It executes again
The step S330 extracts the puncture tube 200.It finally executes the step S340 and waits for that the soluble glue 140 loses viscosity
Afterwards, the first fixed-wing 122 of first fixing piece 120 opens automatically, is embedded into the destination organization 300.In the step
It needs to keep 100 position of electrode catheter motionless 5 minutes in rapid S340, to guarantee that the soluble glue 140 is contacted with body fluid and is opened
Begin to dissolve.After soluble 140 glue gradually dissolves, first free end 1222 is automatic to open, and is embedded into destination organization
300, realize being completely fixed for the electrode catheter 100 and destination organization 300.Oneself of the fixing piece is fixed without using pipe sleeve
It by holding, thus solves since frictional force is larger between casing and electrode catheter fixed structure, causes pole to surgical operation
Big inconvenient problem.
It should be understood that " the first fixing piece 120 " or second fixing piece described in above-mentioned method for implantation 30
130, correspondingly, " first fixed-wing 122 " or second fixed-wing 132.
In one embodiment, present invention also provides a kind of nerve electric stimulation devices 40.The nerve electric stimulation device
40 include above-mentioned nerve electric stimulation electrode assembly 10, further includes impulse generator 410.The impulse generator 410 is set to institute
State connecting pin 113.The impulse generator 410 can emit electric impulse signal.The electric impulse signal passes through the connecting pin
113 reach the stimulated side 115 to stimulate target spot, and target for modulation nerve is by way of electro photoluminescence to reach treatment or improvement
The purpose of disease symptoms.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of nerve electric stimulation electrode assembly characterized by comprising
Soluble glue (140)；
Electrode catheter (100), comprising:
Protection pipe (110), has the connecting pin (113) and stimulated side (115) that are oppositely arranged, the connecting pin (113) for
Impulse generator connection, the stimulated side (115) is for stimulating target spot；
First fixing piece (120), comprising:
First fixed part (121), the first fixed part (121) fixing sleeve are set to the protection pipe (110)；
First fixed-wing (122), first fixed-wing (122) include the first fixing end (1221) and the first free end
(1222), first fixing end (1221) connect with one end of first fixed part (121), first free end
(1222) protection pipe (110) can be adhered to by the soluble glue (140)；
Puncture tube (200), the puncture tube (200) is sheathed on the electrode catheter (100), for assisting the electrode catheter
(100) it is implanted into target spot.
2. nerve electric stimulation electrode assembly as described in claim 1, which is characterized in that the protection pipe further includes at least one
Second fixing piece (130), each second fixing piece (130) include:
Second fixed part (131), the second fixed part (131) fixing sleeve are set to the protection pipe (110)；
Two the second fixed-wings (132), are respectively arranged at the opposite both ends of second fixed part (131), and each described second
Fixed-wing (132) includes the second fixing end (1321) and the second free end (1322), and second fixing end (1321) is set to
Second fixed part (130), second free end (1322) can be adhered to the guarantor by the soluble glue (140)
Pillar (110).
3. nerve electric stimulation electrode assembly as claimed in claim 2, which is characterized in that the protection pipe (110) includes two
First fixing piece (120), first fixing piece (120) are respectively arranged at the two sides of second fixing piece (130), and
The direction of two first free ends (1222) is opposite.
4. nerve electric stimulation electrode assembly as described in claim 1, which is characterized in that the protection pipe includes multiple described
One fixing piece (120), the axis direction along the protection pipe (110), the direction of at least one first free end (1222)
It is opposite with the direction of the first free end (1222) described in other.
5. nerve electric stimulation electrode assembly as described in claim 1, which is characterized in that the protection pipe is divided into the first fixed area
(125) and the second fixed area (126), described the first of first fixed area (125) and second fixed area (126) setting
The quantity of fixing piece (120) is identical, is located at first free end (1222) of first fixed area (125) and is located at described
The direction of first free end (1222) of second fixed area (126) is opposite.
6. nerve electric stimulation electrode assembly as described in claim 1, which is characterized in that first fixed-wing (122) includes
Multiple fixinig plates (124), the multiple fixinig plate (124) are the multiple solid around the setting of first fixed part (121) interval
Stator (124) fits in the protection pipe (110), and the solubility glue (140) puts the edge for being applied to the fixinig plate (124).
7. nerve electric stimulation electrode assembly as described in claim 1, which is characterized in that the solubility glue (140) is coated on
First fixed-wing (122) is external, forms one layer of film for surrounding first fixed-wing (122), first free end
(1222) protection pipe (110) can be adhered to by the soluble glue (140).
8. nerve electric stimulation electrode assembly as described in claim 1, which is characterized in that the material of the solubility glue (140)
For starch, dextrin, cellulose, polyvinylpyrrolidone or N vinylamide polymer.
9. nerve electric stimulation electrode assembly as described in claim 1, which is characterized in that the material of first fixing piece (120)
Material is polyurethane, silicon rubber or polyurethane-silastic polymer.
10. a kind of preparation method of nerve electric stimulation electrode assembly as claimed in any one of claims 1-9 wherein, feature exist
In, comprising the following steps:
The first fixed part (121) of first fixing piece (120) is sheathed on and is fixed on the protection pipe (110)；
External force is applied to the first fixed-wing (122) of first fixing piece (120), is bonded first free end (1222)
In the protection pipe (110)；
The soluble glue (140) is applied between first free end (1222) and the protection pipe (110)；
After the solubility glue (140) solidifies, remove the external force of application so that first free end (1222) fit in it is described
Protection pipe (110).
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| CN201910339477.5A CN109908467B (en) | 2019-04-25 | 2019-04-25 | Nerve electric stimulation electrode assembly and preparation method thereof |
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| CN111686369A (en) * | 2020-06-22 | 2020-09-22 | 山东大学齐鲁医院 | Barb device and system for preventing sacral nerve stimulation electrode from inwards shifting |
| WO2024017027A1 (en) * | 2022-07-19 | 2024-01-25 | 景昱医疗科技（苏州）股份有限公司 | Transmission module and electrical stimulation device |
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| CN109908467B (en) | 2024-04-30 |
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