CN205055188U - Neural electric stimulating electrode subassembly of implanted and electrode pipe thereof - Google Patents
Neural electric stimulating electrode subassembly of implanted and electrode pipe thereof Download PDFInfo
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- CN205055188U CN205055188U CN201520724822.4U CN201520724822U CN205055188U CN 205055188 U CN205055188 U CN 205055188U CN 201520724822 U CN201520724822 U CN 201520724822U CN 205055188 U CN205055188 U CN 205055188U
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- protective casing
- fixture
- electrode catheter
- electrical stimulation
- implantable neural
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Abstract
The utility model relates to a neural electric stimulating electrode subassembly of implanted, including an electrode pipe, one be used for seeking the pjncture needle of target spot and one be used for assisting the puncture tube of target spot is put into to the electrode pipe, the electrode pipe includes wire, protective case and mounting, the wire is located protective case runs through whole protective case, the mounting cover is located protective case's predetermined position, protective case is that one end opening one end is closed, the sleeve pipe structure of interior sky, protective case the opening tip is provided with the connection ends including a plurality of connecting terminals, and closed end is provided with including a plurality of amazing tip that contact, protective case's middle part is provided with the mounting and visuals the mark.
Description
Technical field
This utility model belongs to implantation medical equipment manufacturing technology field, is specifically related to a kind of implantable neural electrical stimulation electrode assemblie and electrode catheter thereof.
Background technology
Implantable neural electrical stimulator is a kind of active implantable medical devices.Implantable neural electrical stimulator by the mode of electricity irritation come excited, suppress or nervous system regulation conduction, thus reach the therapeutic effect recovering or improve function of human body running.Implantable neural electrical stimulation therapy has been proved plants maladjusted nervous system disease to more than 20 and has definite curative effect.Compare with surgical operation damage method with traditional pharmaceutical methods, implantable nerve irritation therapy safety is reversible, is used just more and more clinically.Implantable neural electrical stimulator is according to the difference of stimulation location, implanted lesions located in deep brain system, implanted cortex stimulating system can be subdivided into, implanted spinal cord stimulation trial system, implanted Sacral nerve electrical stimulation system, implanted vagus nerve electric stimulation etc., or be called brain depth stimulator, vagus nerve stimulator, spinal stimulator, sacral nerve stimulator, peripheral nerve stimulation device etc.
Similar with widely used cardiac pacemaker system, implantable neural electrical stimulator is also made up of the electrode catheter of the pulse generator and transmission stimulus signal that produce stimulus signal.The signal that pulse generator produces is delivered to stimulation location (target spot) by electrode catheter and produces therapeutic effect.To obtain therapeutic effect steady in a long-term, must holding electrode supravasal stimulation contact and target position constant.Therefore, when electrode catheter is implanted, should adopt an effective measure is fixed electrode catheter and tissue.
One class of current extensive use is realized by the independently device such as fixation clamp (or fixed sleeving, mooring anchor), the relevant apparatus such as, mentioned in U.S. Patent application US20090030492A1, US005484445A.
Fixation clamp and tissue, fixation clamp and electrode catheter fix when implanting by the electrode assemblie of this kind of implantable neural electrical stimulator respectively, thus realize fixing between electrode catheter and tissue, this implantable neural electrical stimulation electrode assemblie needs larger operative incision usually, larger to damage to patient.
Utility model content
In view of this, necessaryly provide that a kind of structure is simple, doctor is easy to operation, little, the lower-cost implantable neural electrical stimulation electrode assemblie of patient trauma and electrode catheter thereof.
Implantable neural electrical stimulation electrode assemblie comprises one for finding a puncture needle for target spot, described puncture needle is provided with labelling groove, one electrode catheter, it comprises wire, protective casing and fixture, described wire is positioned at described protective casing and runs through whole described protective casing, described fixture is sheathed on the predetermined position of described protective casing, described protective casing is that one end open one end is closed, the sleeve structure body of interior sky, described protective casing, the end adjacent with described opening is provided with the connecting end portion comprising multiple connecting terminal, the end adjacent with described closing end is provided with the stimulation end comprising multiple stimulation contact, the middle part of described protective casing, described stimulation end is provided with fixture, the first visual label of the supervision to paracentesis depth when implanting for electrode catheter is provided with between described connecting end portion and described fixture, position after described fixture is used for the implantation of described electrode catheter is fixed, and, one puncture tube, target spot is put into for auxiliary described electrode catheter, described puncture tube is tubular body structure, the internal diameter of described puncture tube is greater than the external diameter of described electrode catheter and described puncture needle, described puncture tube can be sheathed on described electrode catheter and described puncture needle, described puncture tube is provided with labelling groove.
Described fixture comprises multiple fixed-wing and a fixed part; described multiple fixed-wing and a fixed part are structure as a whole body; described fixture is sheathed on described protective casing by described fixed part; each fixed-wing is connected with described fixed part; each fixed-wing in a free state free end away from described fixed part direction tilt extend; collapsible by external force, remove external force elastic return free state.
The material of described fixture is polyurethane, silicone rubber or polyurethane-silastic copolymer.
The middle part of described protective casing, be provided with one second visual label further, described second visual label is between described first visual label and described connecting end portion.
The middle part of described protective casing, be provided with two X-ray developing marks further, in the initial position of described fixture with stop position and respectively arrange one.
Described wire is stainless steel wire, vitallium line, Nitinol line, platinumiridio line, tungsten alloy wire or carbon nano tube line.
The surface of described wire is provided with the group improving lubricity or biocompatibility further and draws synthetic fibre coating or plastic coating of fluoride.
Described stimulation contact is platinum or platinumiridio, or the loop configuration body of surface coverage platinum or platinumiridio coating.
A kind of electrode catheter being applied to implantable neural electrical stimulation electrode assemblie, it comprises wire, protective casing and fixture, described wire is positioned at described protective casing and runs through whole described protective casing, described fixture is sheathed on the predetermined position of described protective casing, described protective casing is that one end open one end is closed, the sleeve structure body of interior sky, described protective casing, the end adjacent with described opening is provided with the connecting end portion comprising multiple connecting terminal, the end adjacent with described closing end is provided with the stimulation end comprising multiple stimulation contact, the middle part of described protective casing, described stimulation end is provided with fixture, the visual label of the supervision to paracentesis depth when implanting for electrode catheter is provided with between described connecting end portion and described fixture, position after described fixture is used for the implantation of described electrode catheter is fixed.
Relative to prior art, the implantable neural electrical stimulation electrode assemblie that this utility model provides has following beneficial effect: the implant surgery of electrode catheter becomes simple puncturing operation by traditional surgical operation, and for doctor, operation technique more simple, operation used time reduces; For patient, can replace general anesthesia with local anesthesia, anesthetic risks reduces greatly, and puncturing operation wound is little simultaneously, and wound healing is fast, makes patient more comfortable.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the implantable neural electrical stimulation electrode assemblie electrode catheter that this utility model first embodiment provides.
Fig. 2 is the application decomposition schematic diagram of the implantable neural electrical stimulation electrode assemblie that this utility model first embodiment provides.
Fig. 3 is the schematic diagram of the implantable neural electrical stimulation electrode assemblie electrode catheter that this utility model second embodiment provides.
Fig. 4 is the schematic diagram of the implantable neural electrical stimulation electrode assemblie that this utility model second embodiment provides.
Fig. 5 is the schematic diagram of the implantable neural electrical stimulation electrode assemblie electrode catheter that this utility model the 3rd embodiment provides.
Fig. 6 is the schematic diagram of the implantable neural electrical stimulation electrode assemblie electrode catheter that this utility model the 4th embodiment provides.
Main element symbol description
| Electrode catheter | 100 |
| Handhold element | 101 |
| Connecting end portion | 110 |
| Connecting terminal | 111 |
| Protective casing | 120 |
| Opening | 121 |
| Closing end | 122 |
| Stimulate end | 140 |
| Stimulate contact | 141 |
| First visual label | 150 |
| Second visual label | 155 |
| Fixture | 160 |
| Fixed-wing | 161 |
| Fixed part | 162 |
| X-ray developing mark thing | 170 |
| Puncture needle | 300 |
| Puncture needle indicia band | 310 |
| Puncture tube | 400 |
| Tissue | 180 |
| Target spot | 185 |
Following detailed description of the invention will further illustrate this utility model in conjunction with above-mentioned accompanying drawing.
Detailed description of the invention
The implantable neural electrical stimulation electrode assemblie and electrode catheter thereof that this utility model embodiment provides is described in detail below with reference to accompanying drawing.The example of described embodiment is shown in the drawings, and wherein identical label represents identical components or has component that is identical or similar functions.Be exemplary below by the embodiment be described with reference to the drawings, be intended to for explaining this utility model, and can not be interpreted as restriction of the present utility model.
In description of the present utility model, it will be appreciated that, term " longitudinal direction ", " transverse direction ", " on ", D score, " front ", " afterwards ", " left side ", " right side ", " vertically ", " level ", " top ", " end " " interior ", orientation or the position relationship of the instruction such as " outward " are based on orientation shown in the drawings or position relationship, only this utility model and simplified characterization for convenience of description, instead of indicate or imply that the device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore can not be interpreted as restriction of the present utility model.
In description of the present utility model, it should be noted that, unless otherwise clearly defined and limited, term " installation ", " being connected ", " connection ", " fixing " should be interpreted broadly, and such as, can be fixedly connected with, also can be removably connect, or integration connect; Can be mechanical connection, also can be that electromagnetic force connects; Can be directly be connected, also indirectly can be connected by intermediary, can be the connection of two element internals.For the ordinary skill in the art, concrete condition the concrete meaning of above-mentioned term in this utility model can be understood.
Refer to Fig. 1 and Fig. 2, this utility model first embodiment provides implantable neural electrical stimulation electrode assemblie.Described implantable neural electrical stimulation electrode assemblie comprises electrode catheter 100, puncture needle 300 and puncture tube 400.Described puncture needle 300 is for finding target stimulation sites, and target stimulation sites is medically also called target spot 185.Described puncture tube 400 puts into target spot for auxiliary electrode conduit 100, and implanting and being used as the element of electricity irritation into human body is described electrode catheter 100.Described implantable neural electrical stimulation electrode assemblie of the present utility model is sold as a whole.
Described electrode catheter 100 comprises handhold element 101, wire (figure does not indicate), protective casing 120 and fixture 160.Described handhold element 101 is inserted in protective casing 120, for the rigidity of intensifier electrode, facilitates operation technique.Described wire 102 is positioned at described protective casing 120 and runs through whole described protective casing 120.Described fixture 160 is sheathed on the predetermined position of described protective casing 120.Handhold element 101, after electrode catheter is implanted, departs from electrode catheter, takes out.
The material of described wire can be the stainless steel wire of tape insulation layer, vitallium line, Nitinol line, platinumiridio line, tungsten alloy wire or carbon nano tube line etc., and the form that can be twisted wire or helix exists, to improve overall anti-fatigue performance.Further, each root of described wire there is the coating for electric insulation, this coating or have the effect improving lubricity or biocompatibility concurrently, such as, draw synthetic fibre coating or plastic coating of fluoride etc. in surface deposition group.
Described protective casing 120 to be relative two ends be opening 121 and closing end 122, the sleeve structure body of interior sky, the head of described closing end 122 is smooth curved surface, such as hemispherical.Described protective casing 120, adjacent with described opening 121 end is provided with connecting end portion 110, and the end adjacent with described closing end 122 is provided with and stimulates end 140.Middle part, the close described stimulation end 140 of described protective casing 120 are provided with fixture 160, are provided with visual label 150 between described connecting end portion 110 and described fixture 160.The material of described protective casing 120 can be polyurethane, silicone rubber or polyurethane-silastic copolymer etc.
Described connecting end portion 110 is provided with multiple connecting terminal 111, and described connecting terminal 111 can be loop configuration body, is made up of, such as MP35N or rustless steel etc. the material with biocompatibility conducted electricity.
Described stimulation end 140 is provided with multiple stimulation contact 141, described stimulation contact 141 can be loop configuration body, be made up of the material with biocompatibility conducted electricity, such as platinum or platinumiridio, or the material of surface coverage platinum or platinumiridio coating, be electrically connected with described wire by the mode of resistance spot welding or laser spot welding.Stimulate contact 141 for platinumiridio ring described in the present embodiment.
Described multiple connecting terminal 111 is for receiving different pulse signals or the pulse signal of different time sections, the pulse signal that described multiple connecting terminal 111 receives is sent to different stimulation contacts 141 by different wires, carries different pulse signals or the pulse signal etc. of different time sections to realize multiple stimulation contact 141 to target spot 185.Connected by corresponding wire between corresponding connecting terminal 111 with stimulation contact 141, split by insulator, to keep electrical isolation between adjacent described multiple connecting terminal 111 or described multiple stimulation contact 141.
The supervision to paracentesis depth when described visual label 150 is implanted for electrode catheter; can be etching on described protective casing 120, brush, paste color or the structure with obvious distinction; such as on described protective casing 120, brush white stripes, or paste white ribbon etc. on described protective casing 120.In the present embodiment, described visual label 150 is the indicia band be pasted onto with white silicone rubber strip on described protective casing 120.
In the present embodiment; the number of described fixture 160 is four; each fixture 160 comprises four fixed-wings 161 and a fixed part 162; described fixture 160 is sheathed on described protective casing 120 by fixed part described in it 162; each fixed-wing 161 is connected with described fixed part 162, each fixed-wing 161 in a free state free end away from described fixed part 162 direction tilt extend.Described fixture 160 is fixed for the position after described electrode catheter 100 implantation.Described fixture 160 has one direction contractility, when described electrode catheter 100 is implanted by described puncture tube 400, described fixed-wing 161 shrinks, conveniently to puncture implantation, and described fixed-wing 161 automatically opens, is embedded in tissue after the implantation, fixation is produced to electrode catheter.The material of described fixture 160 is polyurethane, silicone rubber or polyurethane-silastic copolymer.In the present embodiment, the silastic material that described fixture 160 is 80D by hardness makes, and the fixed part 162 of described fixture 160 is bonded on described protective casing 120 by adhesive.
Described puncture needle 300, for finding target spot 185, described puncture needle 300 is provided with labelling groove 310, and described puncture tube 400 puts into target spot 185 position for the stimulation contact 141 of auxiliary described electrode catheter 100.The interior caliber of described puncture tube 400 is greater than the external diameter of described puncture needle 300 and electrode catheter 100, to such an extent as to makes described puncture tube 400 be sheathed on described puncture needle 300 or electrode catheter 100 smoothly.Described puncture tube 400 is provided with labelling groove (sign).The using method of the described implantable neural electrical stimulation electrode assemblie that the present embodiment provides is further illustrated here by Fig. 2.Apply implantable neural electrical stimulation electrode assemblie Shi doctor of the present utility model first described puncture needle 300 to be put into tissue 180 and search out target spot 185 position, now the described labelling groove 310 of described puncture needle 300 exposes to tissue 180, then described puncture tube 400 is placed in tissue 180 along described puncture needle 300, labelling groove on described puncture tube 400 is alignd with the labelling groove 310 on described puncture needle 300, described puncture needle 300 is extracted subsequently from tissue 180, by the hollow space implant into body tissue 180 of electrode catheter 100 by described puncture tube 400, treat that the visual label 150 on electrode catheter 100 aligns with the labelling groove on puncture tube 400, namely shown that electrode catheter arrives precalculated position.Extract described puncture tube 400 from tissue 180 subsequently, the fixed-wing 161 of the described fixture 160 on described electrode catheter 100 opens, is embedded into tissue 180, realizes the fixing of described electrode catheter 100.
Refer to Fig. 3 and Fig. 4, the implantable neural electrical stimulation electrode assemblie that this utility model second embodiment provides and electrode catheter 100.Implantable neural electrical stimulation electrode assemblie and the electrode catheter 100 of the implantable neural electrical stimulation electrode assemblie of the present embodiment and electrode catheter 100 and above-mentioned first embodiment are substantially identical, difference is, described electrode catheter 100 comprises one second visual label 155 further, this second visual label 155 keeps at a certain distance away with described first visual label 150, arrange near described connecting end portion 110 relative to described first visual label 150, therefore described second visual label 155 is between described first visual label 150 and described connecting end portion 110.
Electrode catheter 100 is inserted human body along puncture tube 400 by the implantable neural electrical stimulation electrode assemblie Shi doctor of application the present embodiment, when the first visual label 150 of electrode catheter 100 aligns with the end face of puncture tube 400, the stimulation end 140 of electrode catheter 100 arrives precalculated position, now stops the insert action of electrode catheter 100; Then holding electrode conduit 100 is motionless, is outwards pulled out by puncture tube 400, and when the end face of puncture tube 400 aligns with the second visual label 155 of electrode catheter 100, the fixture 160 of electrode catheter 100 stretches out puncture tube 400 completely.When the fixture 160 of electrode catheter 100 is in puncture tube 400, its fixed-wing 161 is in compressive state, now there is larger frictional force between electrode catheter 100 and puncture tube 400, during this period, doctor should carefully operate, and avoids electrode catheter 100 or puncture tube 400 to move with the other side.
Refer to Fig. 5, the electrode catheter 100 of the implantable neural electrical stimulation electrode assemblie that this utility model the 3rd embodiment provides.The electrode catheter 100 of the implantable neural electrical stimulation electrode assemblie of the present embodiment is substantially identical with the electrode catheter 100 of the implantable neural electrical stimulation electrode assemblie of above-mentioned first embodiment, difference is, described electrode catheter 100 comprises two X-ray developing marks 170 further, is arranged at the initial position of described fixture 160 and stops each one of position.Described X-ray developing mark 170 determines the position of fixture 160 under X-ray after implanting for electrode catheter 100.Described X-ray developing mark 170 is made by the material larger to X-ray attenuation by absorption, the such as polymer etc. of tantalum, platinum, platinumiridio, platinum-tungsten alloys or baric.In the present embodiment, X-ray developing mark 170 is made by platinumiridio.
Refer to Fig. 6, the electrode catheter 100 of the implantable neural electrical stimulation electrode assemblie that this utility model the 4th embodiment provides.The electrode catheter 100 of the implantable neural electrical stimulation electrode assemblie of the present embodiment is substantially identical with the electrode catheter 100 of the implantable neural electrical stimulation electrode assemblie of above-mentioned second embodiment, difference is, described electrode catheter 100 comprises two X-ray developing marks 170 further, is arranged at the initial position of described fixture 160 and stops each one of position.Described X-ray developing mark 170 determines the position of fixture 160 under X-ray after implanting for electrode catheter 100.Described X-ray developing mark 170 is made by the material larger to X-ray attenuation by absorption, the such as polymer etc. of tantalum, platinum, platinumiridio, platinum-tungsten alloys or baric.In the present embodiment, X-ray developing mark 170 is made by platinumiridio.
Relative to prior art, the implantable neural electrical stimulation electrode assemblie that this utility model provides has following beneficial effect: the implant surgery of electrode catheter becomes simple puncturing operation by traditional surgical operation, and for doctor, operation technique more simple, operation used time reduces; For patient, can replace general anesthesia with local anesthesia, anesthetic risks reduces greatly, and puncturing operation wound is little simultaneously, and wound healing is fast, makes patient more comfortable.
In addition, those skilled in the art also can do other changes in this utility model spirit, and certainly, these changes done according to this utility model spirit, all should be included within this utility model scope required for protection.
Claims (9)
1. an implantable neural electrical stimulation electrode assemblie, is characterized in that, comprising:
One, for finding the puncture needle of target spot, described puncture needle is provided with labelling groove;
One electrode catheter, it comprises wire, protective casing and fixture, described wire is positioned at described protective casing and runs through whole described protective casing, described fixture is sheathed on the predetermined position of described protective casing, described protective casing is that one end open one end is closed, the sleeve structure body of interior sky, described protective casing, the end adjacent with described opening is provided with the connecting end portion comprising multiple connecting terminal, the end adjacent with described closing end is provided with the stimulation end comprising multiple stimulation contact, the middle part of described protective casing, described stimulation end is provided with fixture, the first visual label of the supervision to paracentesis depth when implanting for electrode catheter is provided with between described connecting end portion and described fixture, position after described fixture is used for the implantation of described electrode catheter is fixed, and,
One puncture tube, target spot is put into for auxiliary described electrode catheter, described puncture tube is tubular body structure, the internal diameter of described puncture tube is greater than the external diameter of described electrode catheter and described puncture needle, described puncture tube can be sheathed on described electrode catheter and described puncture needle, described puncture tube is provided with labelling groove.
2. implantable neural electrical stimulation electrode assemblie as claimed in claim 1; it is characterized in that; described fixture comprises multiple fixed-wing and a fixed part; described multiple fixed-wing and a fixed part are structure as a whole body; described fixture is sheathed on described protective casing by described fixed part, and each fixed-wing is connected with described fixed part, each fixed-wing in a free state free end away from described fixed part direction tilt extend; collapsible by external force, remove external force elastic return free state.
3. implantable neural electrical stimulation electrode assemblie as claimed in claim 2, it is characterized in that, the material of described fixture is polyurethane, silicone rubber or polyurethane-silastic copolymer.
4. implantable neural electrical stimulation electrode assemblie as claimed in claim 1; it is characterized in that; the middle part of described protective casing, be provided with one second visual label further, described second visual label is between described first visual label and described connecting end portion.
5. the implantable neural electrical stimulation electrode assemblie as described in claim 1 or 4, is characterized in that, the middle part of described protective casing, is provided with two X-ray developing marks further, in the initial position of described fixture with stop position and respectively arrange one.
6. implantable neural electrical stimulation electrode assemblie as claimed in claim 1, is characterized in that, described wire is the stainless steel wire of tape insulation layer, vitallium line, Nitinol line, platinumiridio line, tungsten alloy wire or carbon nano tube line.
7. implantable neural electrical stimulation electrode assemblie as claimed in claim 6, it is characterized in that, the surface of described wire is provided with the group improving lubricity or biocompatibility further and draws synthetic fibre coating or plastic coating of fluoride.
8. implantable neural electrical stimulation electrode assemblie as claimed in claim 1, it is characterized in that, described stimulation contact is platinum or platinumiridio, or the loop configuration body of surface coverage platinum or platinumiridio coating.
9. one kind is applied to the electrode catheter of implantable neural electrical stimulation electrode assemblie, it is characterized in that, comprise wire, protective casing and fixture, described wire is positioned at described protective casing and runs through whole described protective casing, described fixture is sheathed on the predetermined position of described protective casing, described protective casing is that one end open one end is closed, the sleeve structure body of interior sky, described protective casing, the end adjacent with described opening is provided with the connecting end portion comprising multiple connecting terminal, the end adjacent with described closing end is provided with the stimulation end comprising multiple stimulation contact, the middle part of described protective casing, described stimulation end is provided with fixture, the visual label of the supervision to paracentesis depth when implanting for electrode catheter is provided with between described connecting end portion and described fixture, position after described fixture is used for the implantation of described electrode catheter is fixed.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520724822.4U CN205055188U (en) | 2015-09-18 | 2015-09-18 | Neural electric stimulating electrode subassembly of implanted and electrode pipe thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520724822.4U CN205055188U (en) | 2015-09-18 | 2015-09-18 | Neural electric stimulating electrode subassembly of implanted and electrode pipe thereof |
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| CN205055188U true CN205055188U (en) | 2016-03-02 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111990995A (en) * | 2020-09-10 | 2020-11-27 | 中国科学院半导体研究所 | Flexible electrode implantation system |
| CN113577536A (en) * | 2020-04-30 | 2021-11-02 | 浙江迈达佩思医疗科技有限公司 | Implanted lead electrode, preparation method and sacral nerve stimulator |
-
2015
- 2015-09-18 CN CN201520724822.4U patent/CN205055188U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113577536A (en) * | 2020-04-30 | 2021-11-02 | 浙江迈达佩思医疗科技有限公司 | Implanted lead electrode, preparation method and sacral nerve stimulator |
| CN113577536B (en) * | 2020-04-30 | 2024-02-27 | 浙江迈达佩思医疗科技有限公司 | Implantable lead electrode, preparation method and sacral nerve stimulator |
| CN111990995A (en) * | 2020-09-10 | 2020-11-27 | 中国科学院半导体研究所 | Flexible electrode implantation system |
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Effective date of registration: 20160930 Address after: 102200 Beijing city Changping District Nan Shao Zhen Xing Chang Road No. 1 Building 1 layer 5 Patentee after: Beijing Pins Medical Co., Ltd. Address before: 100084 Beijing Beijing 100084-82 mailbox Patentee before: Tsinghua University Patentee before: Beijing Pins Medical Co., Ltd. |