CN109603010B - A kind of preparation method of even the optical fiber puncture needle of light and slit and light uniforming device out - Google Patents
A kind of preparation method of even the optical fiber puncture needle of light and slit and light uniforming device out Download PDFInfo
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- CN109603010B CN109603010B CN201811332047.2A CN201811332047A CN109603010B CN 109603010 B CN109603010 B CN 109603010B CN 201811332047 A CN201811332047 A CN 201811332047A CN 109603010 B CN109603010 B CN 109603010B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N2005/0612—Apparatus for use inside the body using probes penetrating tissue; interstitial probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
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Abstract
The present invention relates to the preparation method of a kind of even the optical fiber puncture needle of light and slit and light uniforming device out, optical fiber puncture needle includes optical fiber, and optical fiber includes main part, and main part is connect with the light uniforming device that can uniformly go out light；Light uniforming device includes the pipe sleeve that its inner wall has reflecting effect, and the side of the pipe sleeve is equipped with the slit that can go out inside and outside pipe sleeve and uniformly light；The periphery of main part is enclosed with main body tube, and the periphery of light uniforming device is enclosed with point petaloid syringe needle being made of memory metal.The puncture needle passes through the mutual synergistic effect of all parts, can be realized the purpose transmitted in long blood vessel faster, as can smoothly walking nearly 2 meters of length of vessel；And can be realized higher light extraction efficiency and therapeutic effect, there is important application value and meaning in photodynamic tumor-treatment.
Description
Technical field
The present invention relates to a kind of the field of medical instrument technology, and in particular to it is a kind of it is even go out light optical fiber puncture needle and slit and
The preparation method of light uniforming device.
Background technique
Photodynamic therapy (Photodynamic Therapy, PDT) is to carry out medical diagnosis on disease using photodynamic effect and control
A kind of new technology treated.Its exposure basis is photodynamic effect.This is a kind of light of adjoint biological effect for having oxygen molecule to participate in
Sensitized reaction.Its process is that the laser irradiation of specific wavelength excites the photosensitizer of tissue resorption, and excitation state is photosensitive
Agent generates highly active singlet oxygen, oxygen occurs for singlet oxygen and adjacent large biological molecule again energy transmission to the oxygen of surrounding
Change reaction, generates cytotoxic effect, and then lead to cell damage or even death.Compared to traditional remedies, photodynamic therapy has
Wound is small, targeting is good, without drug resistance and the advantages of toxic side effect.But since the main wavelength of photodynamic therapy concentrates on more than 600
The red spectral band of nanometer, this wave band is big in the loss of people's body absorption, can only generally transmit several millimeters to tens of milliseconds magnitude, for
Some deep tumors can not play the role of effective optical dynamic therapy.By optical fiber, endoscope and other interventional techniques, can incite somebody to action
Laser aiming is treated to internal deep, the wound and pain caused by operation such as avoids out chest, opens abdomen.It uses and contains at present
The puncture needle of optical fiber can introduce light into vivo, but due to needing to export light from optical fiber, needle point needs to have sufficiently large
Small hole increases the diameter of syringe needle so that light appears.To overcome penetration Resistance, optical fiber is wrapped up by hard metal material,
Needle tubing is thicker, needs to make its puncture using very big pressure in puncture process, be easy to cause biggish wound, destroy normal blood
Tubing causes bleeding.Therefore, in response to this series of problems, the application has studied a kind of memory metal optical fiber puncture needle tubing.
Further, since fiber end face generally only has several microns to hundred micron dimensions, the shadow surface of the tissue by laser of outgoing
Product very little, needs a kind of dodging device that laser is evenly distributed on lesions position.It in general, is edge to the requirement of dodging device
Side goes out light, and uniformly light-emitting length is 5mm-20mm or so, and wants sufficiently fine in favor of in the devices such as puncture needle, endoscope
It uses.
It is (such as powder, small by scatterer in fiber cores at present there are many scatter-type lateral emitting dodging device
Ball, grating etc.) light scattered into optical fiber side.Such as United States Patent (USP) U.S.PatNos.5196005 and 5330465 is in optical fiber tail
Scatterer powder is embedded in the silica sandwich layer in portion, and the concentration of scatterer powder increases as length increases.
Scatterer powder selection in U.S.PatNos.5269777 mixes in the surrounding layer of optical fiber, rather than is entrained in fiber core layer
In.U.S.Pat No.4986628 uses the method that scatterer is mixed in polymer.United States Patent (USP) U.S.Pat
Nos.6398778B1 uses production fiber grating pair light in a fiber and is scattered, and fiber grating is type II type Prague
Grating causes refractive index modulation that light laterally sheds along optical fiber by grating.U.S.PatNo.5207669 is proposed multimode light
Fine surrounding layer is constituted along the mode that fiber length is gradually thinned.Due to being thinned for surrounding layer, the portion transmitted in fiber cores
Light splitting is issued by way of dredging the wave that dies to side surface coupling, and remaining continuation is transmitted in the core and is persistently coupled out optical fiber.
Above various methods for constituting even beam devices have some shortcomings point, including make special doping concentration scatterer and
The fiber grating of gradual change specification needs higher processing technology, inevitably causes the rising of cost；Partial dispersion body structure
Breakage caused by heat absorption is easy to produce when light intensity is stronger, to destroy light uniforming device function；Due to scatterer and grating
Etc. being scattered to lateral 360 degree, be unable to control it is lateral go out light direction, power dispersion is within 360 degree radial, if lesion portion
Light is caused excessively to disperse and the lesion tissue optical power density deficiency of side in irradiation area side in position.
Summary of the invention
In view of this, the object of the present invention is to provide the preparations of a kind of even the optical fiber puncture needle and slit and light uniforming device of light out
Method solves the deficiencies in the prior art.
The purpose of the present invention is be achieved through the following technical solutions:
An inventive point of the invention is to provide a kind of optical fiber puncture needle of even light out comprising optical fiber, the optical fiber include
Main part, the main part are connect with the light uniforming device that can uniformly go out light；
The light uniforming device is the guiding device being made of tubular structure or club shaped structure, which includes its inner wall tool
There is the pipe sleeve of reflecting effect, the side of the pipe sleeve is equipped with the slit that can go out inside and outside pipe sleeve and uniformly light；
The periphery of the main part is enclosed with main body tube, and the periphery of the light uniforming device is enclosed with point being made of memory metal
Petaloid syringe needle, the heating under illumination effect of point petaloid syringe needle generate deformation to opening and make the light of optical fiber from the front end of pipe sleeve and
The slit of side projects；This point of petaloid syringe needle is made of multiple conical lobes；
When temperature is T0, each conical lobe closure in point petaloid syringe needle being made of memory metal, closure later should
Dividing petaloid syringe needle is in cone shape structure, and is closed this point of petaloid syringe needle later and is wrapped in outside light uniforming device just；
When temperature is T1, each conical lobe in point petaloid syringe needle being made of memory metal is opened, the light uniforming device
Outside is exposed to so that light is uniformly exported from light uniforming device.
Further, the guiding device is any one in following two structure: (a) guiding device is internal
Pipe sleeve with cavity, light is transmitted by the reflection of pipe sleeve inner wall, and is uniformly exported from slit；(b) the guide-lighting dress
It sets including transparent rods and pipe sleeve, the pipe sleeve is sleeved on outside transparent rods, and light transmits under the reflex of pipe sleeve along transparent rods,
And it is uniformly exported from the slit of pipe sleeve.
Further, the optical fiber further includes head, and the rear end on the head is connect with main part, and the front end on head is set
There is the light uniforming device；The head is wrapped with metal-coating；The metal-coating is equipped with dentalation so that it is preceding
Into when resistance small retrogressing when resistance it is big, to effectively reduce the thrust for puncturing and needing.
Further, the length of the guiding device is 5mm-20mm, and the internal diameter of guiding device is 0.1-2mm.
Further, the main body tube is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is to be cut using laser
Cut the helical structure to form helical form joint-cutting；The length of main body tube is 1-2m.
Further, the inner wall of the pipe sleeve be reflective type inner wall with metallic diaphragm reflector or first polishing treatment again
It is coated with the metallic diaphragm with reflecting effect.
Further, the shape of the slit includes bar shaped, helical form or hole shape, and the slit of described hole shape is by more
The bar shaped that a hole is constituted or spiral helicine slit.
Further, the size of the slit are as follows: 1. slit width meets formula with length variationIts
In, d (z) is the width of slit；L is the length of pipe sleeve；Z is the transmission direction along light, the length at measuring point slit point；
R is the internal diameter of guiding device；Width by controlling slit can be such that the light of outgoing is uniformly distributed.The formula is also of the invention
One inventive point.
Further, 2. the outgoing transmitance of the slit meets formulaWherein, T (z) be
The transmitance that light is emitted out of slit at z.The formula is also an inventive point of the invention.
Further, when transmitance T (z) < 1, at z the width of slit and formula 1. in d (z) equivalent width；Work as transmission
When rate T (z) > 1, the width of slit needs to be modified on the basis of formula 1. middle calculating resulting d (z) at z.
Another inventive point of the invention is to provide the production method of slit described in one kind, the method are as follows: in pipe sleeve
Above it is capable of the slit of even light out by the methods of machining or etching production, the width d coincidence formula of the slit is 1.
Resulting width is calculated, by slit obtained by this method, the transmitance of light is almost the same everywhere.
Another inventive point of the invention is to provide a kind of production method of light uniforming device, the method are as follows:
If A. guiding device is a pipe sleeve, preparation method are as follows: the then pipe sleeve for preparing tubular structure is made on pipe sleeve
Make the slit for capableing of even light out；If B. guiding device includes pipe sleeve and transparent rods, preparation method are as follows: transparent described in preparing
Stick, then high reflecting metal film is plated by plated film mode outside transparent rods and constitutes reflection-type light guide structure, the metal film structure plated
At the pipe sleeve of metal material.
It is main to have the present invention provides the preparation method of a kind of even the optical fiber puncture needle of light and slit and light uniforming device out
Beneficial effect are as follows:
The puncture needle be can be realized and be transmitted in long blood vessel faster by the mutual synergistic effects of all parts
Purpose, as can smoothly walking nearly 2 meters of length of vessel；And can be realized higher light extraction efficiency and therapeutic effect, in light
There is important application value and meaning in power oncotherapy.And the puncture needle tubing can also be applied in other fields, such as
Eliminate blood vessel occlusion or carry out vascular puncture etc..The forms such as metal coating can be used in pipe sleeve by light in light uniforming device in puncture needle
Output is reflected from the slit of pipe sleeve side, while the width by controlling slit makes light radially keep uniformly, realizing along pipe sleeve
The function of the even light of single-sided linear, certainly, slit may be configured as helical form or hole shape etc., therefore can also realize that spiral linear goes out light
Or along the dotted light out of unilateral line/helix.
In addition, the setting of slit can not only expand lighting area in light uniforming device, and even light out is able to ascend for affected part
Radiation response, improve the utilization rate of light, it is final to improve illumination efficiency and therapeutic effect.Importantly, its with it is seamless
Metal tube is compared, more soft, i.e., can be improved the flexibility of light uniforming device on the basis of rigidity, so as in the blood vessel into
Row preferably walking.And the present invention cleverly uses the characteristic of memory metal, and creative with body temperature, the thermal effect of light
It should wait and be combined, realize in transmission process, a point petaloid syringe needle for closure can be punctured, and be conducive to during walking
Across blood vessel walking, practicability are stronger；And by the heating effect of light so that will divide in illumination petaloid syringe needle open, make light from
It is exported in light uniforming device and shines directly into purpose position and realize treatment etc..
The application uses the effective exposure rate for making light to greatly promote by light uniforming device, is conducive to illumination and photosensitizer
Effectively cooperation, the waste for reducing light or photosensitizer reduce cost to increase therapeutic effect.
From power, the application gives the formula of gap width, can guarantee the uniform in light emission of gap everywhere substantially,
So that the gap production of even light out has the foundation of a quantization, production is more convenient, and effect is more preferable.And the present invention passes through in metal
Pawl shape structure is designed outside housing, then cooperates vibrating motor, realizes effective transmission that is convenient, being not easy retrogressing of advancing, has
Conducive to smoothly walking in the blood vessel.And the specific structure setting of metal-coating can not only proof strength and flexibility, also one
A important function be just their ability to vibrating motor cooperate can regular generation smile deformation, before facilitating in the blood vessel
Row.
The puncture needle can be used in a variety of diseases that treatment needs light to irradiate, swollen more particularly to be used in light power well
In tumor, to irradiate the tumor tissues for having photosensitizer, photosensitizer is made to play the effect for the treatment of tumour under the irradiation catalysis of light.It is whole
For body, clinical good application effect is practical, has biggish application value.
Detailed description of the invention
Structural schematic diagram when Fig. 1 is the optical fiber puncture needle closure；
Fig. 2 is the structural schematic diagram when optical fiber punctures needle open；
Fig. 3 is free from the schematic perspective view of the guiding device of transparent rods；
Fig. 4 is the structural schematic diagram of the guiding device containing transparent rods；
Fig. 5 is the cross section structure schematic diagram of the guiding device containing transparent rods；
Fig. 6 is the transmittance distribution schematic diagram in slit different places；
Fig. 7 is the even light effect two-dimensional representation at the outer 1mm of slit；
Fig. 8 be at the central axes Fig. 5 light intensity along the distribution schematic diagram of slit length z；
Fig. 9 is the structural schematic diagram of spiral slit on pipe sleeve；
Figure 10 is the structural schematic diagram of another spiral slit on pipe sleeve；
Figure 11 is the structural schematic diagram of hole shape slit on pipe sleeve；
Figure 12 is the structural schematic diagram that pipe sleeve is pyramidal structure；
Figure 13 is the structural schematic diagram of optical fiber puncture needle described in embodiment 10；
Figure 14 is the structural schematic diagram of optical fiber puncture needle head and conical lobe；
Figure 15 is the cross section structure schematic diagram of optical fiber puncture needle head and conical lobe；
Figure 16 is the structural schematic diagram on optical fiber puncture needle head；
Figure 17 is malformation schematic diagram of the optical fiber puncture needle under the driving of vibrating motor；
Figure 18 is Temperature Distribution schematic diagram when a point petaloid syringe needle has light irradiation；
Figure 19 is the section structural schematic diagram (seeing from inside to outside) of main body tube；
Figure 20 is wound around the cross-sectional structure schematic diagram of the main body tube outside fiber body portion；
Figure 21 is cross-sectional view when point petaloid syringe needle is closed together；
Figure 22 is cross-sectional view when point petaloid syringe needle is opened.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
It is a part of the embodiment of the present invention, instead of all the embodiments.The detailed description of the embodiment of the present invention presented below is simultaneously
It is not intended to be limiting the range of claimed invention, but is merely representative of selected embodiment of the invention.Based in the present invention
Embodiment, this field commonsense method personnel every other embodiment obtained without creative efforts,
It shall fall within the protection scope of the present invention.
Embodiment 1
It is a kind of it is even go out light optical fiber puncture needle comprising optical fiber, the optical fiber include main part 8, the main part 8 with can
Light uniforming device 2 for going out light connects.As shown in Figs. 1-2, due to optical fiber not visible from outside, therefore optical fiber is represented by dashed line.
As shown in figure 3, the light uniforming device 2 is the guiding device being made of tubular structure or club shaped structure, the guiding device
There is the pipe sleeve 11 of reflecting effect including its inner wall, the side of the pipe sleeve 11 is equipped with inside and outside pipe sleeve 11 and can be uniform
The slit 12 of light out, then the light in pipe sleeve 11 can uniformly be projected from slit 12, which can be for through the entire of pipe sleeve
Length direction, or a part of pipe sleeve length direction is configured as needed.
The periphery of the main part 8 is enclosed with main body tube 9, and the periphery of the light uniforming device 2 is equipped with to be made of memory metal
Point petaloid syringe needle 3, the heating under illumination effect of point petaloid syringe needle generate deformation to open make the light of optical fiber from pipe sleeve most before
The slit of end and side projects；Described point of petaloid syringe needle 3 is cone shape, this point of petaloid syringe needle 3 is made of multiple conical lobes 31, such as
Shown in Fig. 5-6.Memory metal includes but is not limited to Nitinol, corronil, albronze, ormolu etc..
When temperature is T0, as shown in Figure 1, each conical lobe 31 in point petaloid syringe needle 3 being made of memory metal closes
It closes, this divides petaloid syringe needle 3 to be in cone shape structure after closure, and this point of petaloid syringe needle 3 is wrapped in even light just after closure
Outside device 2, light can not be appeared；Light uniforming device 2 is wrapped in point valvular structure, light uniforming device 2, and the process walked in the blood vessels are protected
In, circular cone figure divides valvular structure is convenient to walk in the blood vessel, and advance resistance is small, and backing resistance is big, convenient to move ahead.
When temperature is T1, each conical lobe 31 in point petaloid syringe needle 3 being made of memory metal is opened, the sample of opening
Son is as shown in Fig. 2, then the light uniforming device 2 is exposed to outside, and the light emission in optical fiber enters in pipe sleeve, and then light is again from pipe sleeve side
Projected in slit, certain light can also be projected from the opening of pipe sleeve front end, and make project illumination be incident upon in tumour or other
Affected part.
The light uniforming device can be any one in following two structure: 1. the guiding device is internal with cavity
Pipe sleeve, as shown in Fig. 3, in this case, the cavity inside optical fiber and pipe sleeve is concentric or axis, so that the luminous energy in optical fiber
Enough smoothly to enter in pipe sleeve, light is transmitted in empty pipe sleeve by the reflection of pipe sleeve inner wall, is then carried out by slit
The uniform output of light；2. the guiding device includes transparent rods 13 and pipe sleeve 11, the pipe sleeve is sleeved on outside transparent rods 13, is such as schemed
Shown in 4-5, in this case, preferred fiber and 13 closed butt joint of transparent rods be so that light is efficiently transferred in transparent rods 13, due to
The reflex of pipe sleeve 11, light are concentrated mainly in transparent rods 13 and are transmitted, and the uniform output of light is then carried out by slit.
If the opening of pipe sleeve front end is not closed, light can also be exported from pipe sleeve front end simultaneously, if being closed, light is only from slit
Middle output is preferably exported from front end and slit simultaneously depending on actual needs.
As further preferred embodiment, the length of the guiding device is 5mm-20mm, such as 10mm, guiding device
Internal diameter be 0.1-2mm, i.e., the internal diameter of pipe sleeve be 0.1-2mm, such as 0.4mm；Outer diameter is arranged according to actual needs, generally without departing from
The outer diameter of fibre-optic catheter, such as 0.6mm.The light uniforming device of the specification can preferably with some optical fiber applied before the applicant
Conduit carries out fit applications, realizes the high efficiency illumination of deep within the body tumour.When using photosensitizing agents tumour, illumination and light
According to effect play an important role for therapeutic effect, therefore, efficient irradiation can be achieved to promote the effect of therapeutic effect.
As further preferred embodiment, 11 inner wall of pipe sleeve has polishing and/or metal-plated membrane layer, in this way
Inner wall it is few to the consume of light, promote the light transmissioning efficiency of light.
It is preferred that the inner wall of the pipe sleeve 11 is the reflective type inner wall with metallic diaphragm reflector, or first polishing treatment is plated again
There is the metallic diaphragm with reflecting effect, then pipe sleeve inner wall is made to form the film layer of high reflection effect.
It is preferred that the metallic diaphragm includes silverskin or golden film, effect is more excellent.
As further preferred embodiment, the pipe sleeve 11 includes metal pipe sleeve, polymer pipe sleeve or quartz pipe sleeve.
It is reflexive strong but since the refractive index of metal is low, therefore it is preferred that metal pipe sleeve, there is the purpose or technical effect of realizing the application
Benefit.
As further preferred embodiment, the transparent rods 13 are the solid rodlike knot constituted using transparent material
Structure, the transparent material include quartz or polymer etc.；The refractive index of the transparent rods is preferably 1.5, to the efficiency of transmission of light
It is high.
As further preferred embodiment, the slit 12 includes the slit of bar shaped, helical form or hole shape.
In the present embodiment, in use, which is connected into light source, it is logical which can be laser
Optical fiber introducing is crossed, then the light emission in optical fiber enters in pipe sleeve, is also possible to incoherent light and introduces by focusing.By light uniforming device gap
Position alignment needs irradiated site, forms the light field of linear homogeneous distribution, while rotating light uniforming device as needed to irradiated site
It is scanned.
Embodiment 2
On the basis of embodiment 1, can uniformly go out light slit 12 it is necessary to meet following condition, i.e., slit width is with length
1. degree variation meets formulaWherein, d (z) is the width of slit at z；L is the length of pipe sleeve；Z is along light
Transmission direction, the slit length at measuring point z；R is the internal diameter (i.e. the internal diameter of pipe sleeve) of guiding device；By the formula 1. come
The width of control slit can be such that the light of outgoing is uniformly distributed.
In the slit 12 2. the transmitance of light meets formulaWherein, T (z) be at z light from
The transmitance being emitted in slit 12, L are the length of pipe sleeve；Z is the transmission direction along light, the slit length at measuring point z；r
For the internal diameter of guiding device.
As transmitance T (z) < 1, at z the width of slit and formula 1. in d (z) width it is almost the same.
Formula (12) will appear the situation of transmitance infinity or slit width infinity in z=L, therefore in transmitance T > 1
When need practical slit width is modified.I.e. as transmitance T (z) > 1, at z slit width need formula 1. in calculate institute
It is modified on the basis of the d (z) obtained, modified method are as follows: on the basis of the value of transmitance T (z) when T (z) < 1, using mould
Quasi- software carries out simulation calculating to optical output field, corrects practical slit width according to calculated result, reaches the optical output field uniformity most
It is good.
The simulation softward can use LightTools software, and when which can be to T (z) > 1 the case where is effectively repaired
Just.
In the present embodiment, if being not provided with slit at z=L, i.e., along optical transmission direction, the side of front end is not narrow
Seam, then can also be without data correction.
Embodiment 3
On the basis of embodiment 1 or 2, in pipe sleeve in transmission process, part light is exported light by the slit of side.It is logical
The width for crossing control slit can be such that the light of outgoing is uniformly distributed, and derive below to the expression formula of slit width d (z).
Assume initially that the optical transmission direction in pipe sleeve is the direction z, the internal diameter of pipe sleeve is r, and the interior optical power at z of pipe sleeve is
The relationship of P (z), optical power density I (z) and P (z) are as follows:
Or
P (z)=π r2I(z) (2)
Assuming that the width of slit is d (z), then the transmitance T (z) that light is emitted out of pipe sleeve at z at z are as follows:
Therefore the optical power penetrated from gap at available z are as follows:
2 π rdz (4) of dP (z)=- I (z) T (z)
Need to allow the optical power of transmission to keep uniformly now, that is, requiring dP (z) is a constant value, therefore is obtained:
22 π r=const=c (5) of I (z) T (z)
Wherein, const and c refer both to constant；
(5), which are brought into (4), to be obtained:
DP (z)=- cdz (6)
It solves (6), and according to boundary condition P (0)=P0, P (L)=0, can obtain:
By (7)
And it is obtained according to (5) and (8):
(1) is brought into (9) again to obtain:
It is obtained after (7) are brought into (10):
It is obtained further according to (3):
The slit for changing width d (z) with length z is made according to (12) formula, and transmitance can be realized according to (11) formula
The slit of change, so that output intensity is remained unchanged along length z.
Embodiment 4
It is L=10mm, internal diameter r=200um, outer diameter r=according to length on the basis of any one above-mentioned embodiment
The metal hollow pipe of 250um constitutes pipe sleeve 11 as shown in Figure 3, and optical transmission direction is the direction z shown in Fig. 3 arrow.In the z-direction
Be cut by laser to form a gap, gap width according to the formula in embodiment 1 1. (formula (12) i.e. in embodiment 3)
Distribution forms transmitance variation as shown in FIG. 6.
It can be 10 nodes by L=10mm points, the gap width of each node is counted according to theory during actual fabrication
It calculates according to shown in 1 secondary series of table.Formula (12) will appear the situation of transmitance infinity or slit width infinity in z=L, referring to
Shown in Fig. 6, therefore in transmitance T >=1, then gap width d (z) is the perimeter of entire pipeline or is greater than perimeter, this is obviously not
Rationally, it therefore needs to be modified practical slit width.Modification method: simulation calculating is carried out (such as to optical output field by simulation softward
Using optical modeling software: LightTools), practical slit width is corrected according to calculated result, reaches the optical output field uniformity most
It is good.In addition, 6 result progress simple modifications or attached drawing 6 can be also modified with reference to the accompanying drawings in conjunction with optical modeling software, separately
Outside, the amendment of suitability can also rule of thumb be carried out.As long as being corrected very simple using above-mentioned formula.
In this example, the slit width and practical slit width calculated according to formula (12) compares as shown in the table.According to 1 third of table
The slit for arranging (i.e. the width d (z) of actual fabrication) data creating is as shown in Figure 3 and Figure 4.Fig. 7 is placed outside slit 1mm
Screen on light intensity Two dimensional Distribution, Fig. 8 is intensity distribution of the light intensity along central axes, by Fig. 7-8 it is found that the different length in gap
In, distribution of light intensity is almost the same, and the uniformity is very high.
1 gap molded breadth of table and developed width control
, can also be with without modification when z is the random length in 1-8mm in upper table 1, i.e. formula institute through the invention
The gap width d (z) of calculating can use light and keep almost the same, sometimes for more accurate or when making width integer, understand into
The change or modification of row slightly.
In practical applications, in general, formula molded breadth d (z) calculated is equal to or more than radius through the invention
When half (in such as table 1 when z=9-10mm), goes out luminous intensity and need to carry out modification slightly, especially as T >=1, amendment side
Method can refer to optical simulation software progress, and the present embodiment uses LightTools software.
Embodiment 5
On the basis of any one above-mentioned embodiment, a kind of production method of light uniforming device, the method are as follows: if (a) is led
Electro-optical device is hollow pipe sleeve, i.e., pipe sleeve 1. described in embodiment 1, then preparation method can are as follows: prepares the pipe of tubular structure
Then set, such as metal pipe sleeve make the slit on pipe sleeve；It is preferred that preparing inner wall polishing and/or plating highly reflecting films (such as gold
Film or silverskin) pipeline, as inner wall polishes and plate silverskin or golden film；If (b) guiding device is the structure containing transparent rods, i.e., such as
2. guiding device described in embodiment 1, then preparation method are as follows: prepare the transparent rods made of the materials such as quartz, polymer,
High reflecting metal film is plated by plated film mode outside transparent rods again and constitutes reflection-type light guide structure, the metal film plated constitutes
The pipe sleeve of metal material.
Embodiment 6
On the basis of any one above-mentioned embodiment, a kind of production method that slit is, the method are as follows: filled in leaded light
The slit 12 of the production inside and outside pipe sleeve, the width of slit the methods of are cut by laser or etched on the pipe sleeve 11 set
Spend d be by formula 1. (i.e.) calculate resulting width numerical value.If 2. according to formula, containing the feelings of T >=1
Condition can then carry out modification slightly.By slit obtained by this method, the optical power penetrated everywhere is almost the same.
Embodiment 7
On the basis of any one above-mentioned embodiment, the shape of the slit 12 includes bar shaped, helical form or hole shape.
(1) slit of bar shaped is as shown in figs. 34；(2) slit of spiral refers to Fig. 9 and 10, for Fig. 9, by the spiral shell for changing helix
Away from duty ratio change transmittivity T；(3) slit of described hole shape be the bar shaped being made of multiple holes 14 or helical form
Slit, the slit for the bar shaped being made of hole 14 is as shown in Figure 10, is changed by changing circular diameter and distribution density
Become projection ratio T；The spiral helicine slit being made of hole is to substitute in the gap in Fig. 9 or 10 using hole.In addition,
Pipe sleeve can be the pipe sleeve of constant radius, can also be the pipe sleeve of radius variable, i.e. radius r (z) can be changed with z, such as be formed
Taper shown in Figure 12.But the whatsoever whether constant pipe sleeve of the slit and radius of type, any place z in slit
It is all satisfied the transmitance and width of formula (11) and (12).
Embodiment 8
Any one above-mentioned embodiment on the basis of, such as Figure 13-15, the optical fiber further includes head 1, the head
1 rear end and 8 integrally connected of main part are fixedly connected, and the front end (i.e. head free end) on head 1 is provided with the even light
Device 2.The head 1 is wrapped with metal-coating 4,4 tight of metal-coating head 1 periphery so that optical fiber head
Portion 1 and metal-coating 4 are connected as one.
There is dentalation, as illustrated in figs. 13-15, such structure has very little when advancing on the metal-coating 4
Resistance, when retreating, resistance is larger, so as to be punctured, effectively reduced in a manner of progressive to apply in a manner of weak impact
Puncture the pressure needed.
As further preferred embodiment, as illustrated in figs. 13-15, the metal-coating 4 is outside spiral helicine metal
Set, the metal-coating 4 are to carry out laser cutting on metal tube to form the helical structure of helical form joint-cutting to make it have centainly
Intensity increases certain flexibility simultaneously；Then the flight between two neighboring joint-cutting can be runcinate sheet metal, such as scheme
Shown in 12-14.
As further preferred embodiment, as shown in figures 13-16, the sheet metal 41 for constituting metal-coating 4 is in front end
Thickness be less than rear end thickness fall dentalation so that optical fiber puncture needle more easily walks forward and is not easy to retreat.
It is highly preferred that as shown in figure 16, since the thickness c of sheet metal front end is too thin, being not easy to indicate its thickness in the accompanying drawings
Degree, therefore the position of c is only denoted in attached drawing, do not provide its thickness relationship.In falling in dentalation for metal-coating 4, i.e. structure
In structure of the thickness less than the thickness of rear end at the front end of the sheet metal of metal-coating, the thickness c of sheet metal front end is 50-70
μm, the thickness d of sheet metal rear end is 90-110 μm, and the thickness difference of front-end and back-end is 30-50 μm.The control of the thickness for
Effectively smoothly transmission is advanced important, and thickness difference is too big then or to be will increase metal-coating outer diameter or need to reduce gold
The internal diameter for belonging to housing, then be affected to integrated piercing needle tubing, and thickness difference is big, the thickness of sheet metal trailing flank increase compared with
Greatly, it will increase whole advance resistance instead, and for minute blood vessel, also will increase the degree of injury to blood vessel.
If if thickness difference is too small, not having helps to advance, prevents that falls back most to use.
It is highly preferred that in metal-coating 4, as shown in figure 16, the width a of joint-cutting is 0.1-0.2mm, as 0.1mm,
0.15mm, 0.2mm etc., constitute the sheet metal 41 of helical structure width b be 0.2-1mm, as 0.2mm, 0.4mm, 0.6mm,
0.8mm, 1mm etc.；The width a of joint-cutting and the data of width b of sheet metal 41 and the matching relationship of the two directly affect
Blood vessel and the smoothness across blood vessel can be passed through, but also affects the thorn for penetrating into another blood vessel from a blood vessel
Enter intensity.Width a and width b it is too wide it is too narrow can all affect its flexibility and intensity, intensity can not then pass through by force very much blood vessel
Knee, and it is very big to the injury tolerance of blood vessel；It is flexible too strong, then it can not be within the longer blood vessel of length, 1 meter
Length is easier to, but 1 meter or more of blood vessel is difficult across and user bad control and direction in vitro, from a blood
When pipe penetrates into another blood vessel, due to the too low also bad puncture of intensity, the too strong and flexible too intensity of intensity can not be real
It now reaches in the blood vessel or organ of depth into the human body, in liver neoplasm.Only suitable width a cooperates the suitable width side b
Good effect can be achieved.
As further preferred embodiment, the optical fiber, which punctures needle tubing and stays in external one end and be connected with, to be able to carry out
The power device of front and back vibration is so that it can puncture one forward pressure of needle tubing to optical fiber while vibration.
The power device is preferably acoustic vibration motor, and the front and back Oscillation Amplitude of the power device is 10um-500um,
Vibration frequency is 10Hz-1000Hz.
Such as: when puncturing, needle tubing will be punctured and connect acoustic vibration motor, vibration frequency 100Hz, Oscillation Amplitude is
50um.As shown in figure 17, in puncture needle tube vibration, puncture needle tubing overall structure deformation occurs conduction vibration, when vibration forward
When puncture needle miniature deformation occurs, as shown in A, including puncturing the bending of needle tubing and the contraction of screw pitch in metal-coating 4, the bullet
Property deformation promotes needle point to travel forward, and resistance is overcome to puncture forward；When vibrating backward, as indicated atb, due to metal-coating 4
With dentalation, much larger than travelling forward, needle point tends to motionless and puncture needle tubing is pulled integrally to travel forward frictional force.
Under the action of repeatedly vibrating while applying extra pressure, punctures needle tubing and continue to puncture forward.Apply needed for such puncture mode
Pressure is less than traditional puncture needle, therefore it is thinner more soft to allow optical fiber puncture needle, while can complete to puncture effect.
As further preferred embodiment, when being emitted in optical fiber without light, i.e., laser and optical fiber puncture needle tubing
External one end connection, when laser is not turned on, the temperature of point petaloid syringe needle transmitted in vivo is T0, is divided in petaloid syringe needle
Each conical lobe closes up for needle-shaped or cone shape；When optical fiber has light outgoing, i.e., the laser opening connecting with optical fiber makes light
After being transferred to optical fiber, due to the fuel factor of optical fiber, i.e., when light is emitted by conical fiber and is radiated on memory metal, so that by
Point temperature after being illuminated by the light of petaloid syringe needle 3 that memory metal is constituted gradually rises as T1, then divides each taper in petaloid syringe needle
Valve is opened, that is, is more than its phase transition temperature and is generated outside prefabricated deformation, is in open shape, and light uniforming device exposes, and light is from even light
Uniform in the slit of device, and can be emitted simultaneously from the end of pipe sleeve front end.
Temperature T0 can be 37 DEG C, and temperature T1 can be 50 DEG C；Such as: at temperature T0 (such as 37 DEG C), petaloid syringe needle 3 will be divided
Be made as in advance it is close-shaped, temperature be T1 (such as 50 DEG C) when, point petaloid syringe needle 3 in advance is made as open shape.Then puncture in vivo
When, light passing, head do not divide 3 temperature of petaloid syringe needle to be body temperature T0 (37 DEG C) in optical fiber, and point closure of petaloid syringe needle 3 realizes that transmission is worn
Thorn.Leading to 100mW wavelength after being punctured to the predetermined area, in optical fiber is 650nm laser, is radiated by optical fiber light uniforming device by remembering
What metal was constituted divides on petaloid syringe needle 3；As shown in figure 18, Figure 18 is that have 500W/ (m2.K) right in the outside on puncture needle head
Conductance enthusiasm condition (the typical rate of heat dissipation of liquid convection), temperature can be increased to 70.5 DEG C under 100mW laser action, more than T1 temperature
It spends (50 DEG C), generates deformation and open.
As further preferred embodiment, the conical lobe 31 be thereon each equal curvature of point it is consistent, by arc
The conical lobe that face is constituted then makes entirety walk effect more preferable.
The shapes and sizes of all conical lobes 31 are consistent, then the power being distributed on each conical lobe 31 is more evenly, whole
Physical strength degree is bigger.
Divide and contains 2-5 conical lobe, preferably 2 conical lobes or 3 conical lobes in valvular structure；Valve number then each cone too much
Shape valve is too small, and intensity is inadequate.
As further preferred embodiment, the length l on the head is 2.5-10mm, such as 5mm, as shown in figure 13.
The length L of point petaloid syringe needle 3 is 5-30mm, such as 12mm, more slightly longer than light uniforming device, divide petaloid syringe needle 3 or conical lobe 31 with a thickness of
0.06-0.12mm.When its closure, be wrapped in the outside of light uniforming device 2 just, preferable light uniforming device 2 with divide petaloid syringe needle 3 it
Between it is seamless, then light uniforming device 2 then cooperates the cone of specific thicknesses for dividing petaloid syringe needle 3 to have the function of that auxiliary enhances its intensity
Shape valve 31 is conducive to transmission, the piercing etc. that puncture needle tubing, has synergistic effect.
As further preferred embodiment, the length of the main body tube 9 is 1-2m, such as 1.8m, fiber body portion 8 with
The length of main body tube 9 is consistent, and main body tube tight is outer in the main part 8 of optical fiber so that the two is integrally formed, and facilitates transmission.
The main part 8 of optical fiber and the diameter on head 1 can be 400 μm, can be silica fibre, the metal-coating 4 and master
The outer diameter of body pipe 9 can be 600 μm, and internal diameter can be 400 μm.
Phase as further preferred embodiment, when each conical lobe 31 closure, in two neighboring conical lobe 31
Mutually two close close closings in side, this divides valvular structure to constitute totally enclosed cone shape structure, preferably protects light
Fine light uniforming device, light uniforming device are contaminated in transmission process, are influenced the later period and are gone out the exposure rate of light, to will affect tumor locus
The effect of upper photosensitizer.
In the present embodiment, it in use, head end is pierced into blood vessel first, then transmits in the blood vessel, punctures needle tubing
External one end can connect vibrating motor, assist to puncture needle tubing predetermined position reached by blood vessel, such as intracorporal tumour (such as liver
Tumour) it is medium.
Embodiment 9
On the basis of embodiment 8, the main body tube 9 is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is
The helical structure of helical form joint-cutting is formed using laser cutting.
As shown in figure 19, based on Figure 19 pipe section schematic diagram, and be the view seen from inside to outside from main body tube；The master
In body pipe 9, the width a of joint-cutting is 0.02-0.2mm, such as 0.05mm, 0.1mm, 0.15mm, constitutes helical structure in body pipe 9
The width d of flight is 0.5-3mm, such as 1mm, with a thickness of 0.05-0.1mm, such as 0.08mm.Nearly 2 meters of the length of main body tube 9,
It, which penetrates human body, usually just a 1-1.8m, and human vas thickness it is different, there are also certain curvature, such long distance, such as
This special vascular environment, it is very high to its intensity and flexibility requirements, therefore the width d of the width a of joint-cutting, flight and its thickness
Can the data and matching relationship of degree directly affect pass through blood vessel and the smoothness across blood vessel, or even have an effect on head
The intensity of portion's piercing tumor vessel wall.Width a and width d it is too wide it is too narrow can all affect its flexibility and intensity, only close
Suitable width a cooperates the suitable width side d that can realize good effect.
The main body tube 9 is biomedical metallic material, and including but not limited to stainless steel, synthetic fibers, carbon fiber, titanium close
One of gold, Jin Heyin, preferably stainless steel, see on the whole, which wrapped up simultaneously by a stainless steel wire in fact
It is helically wound around the wrapping wire layer of 8 periphery of main part of optical fiber, can also be two or more wrapping wire windings certainly.
As shown in Figure 19-20, the main body tube 9 is externally provided with overcoat polymer 106 to increase the leakproofness of main body tube 9 and subtract
Slight drag；The material of overcoat polymer 106 can be polyamide or polypropylene etc., and other many polymer are ok.It is described poly-
The outside for closing beyond the region of objective existence set 106 is coated with hydrophilic coating 107 to increase blood compatibility.The hydrophilic coating 107 is using chemistry
Stable material is made, including but not limited to polytetrafluoroethylene (PTFE), silicon rubber, polyethylene, polyvinyl chloride, fluorocarbon polymer and poly- ammonia
Ester.Hydrophilic coating is coated, reduces resistance in the blood vessel, the long blood vessel of interior environment complexity can be passed through.
Hydrophobic coating substitution can be used in hydrophilic coating 107 in the present embodiment.
Embodiment 10
On the basis of embodiment 8 or 9, as shown in fig. 21-22, in conical lobe 31, it is used for and adjacent conical valve closing
Or separated side is inclined-plane 105, i.e. there are two sides for a conical lobe 31, and each side is bevel structure.And all cones
105 direction of inclined-plane in shape valve 31 is consistent, i.e., consistent by direction clockwise or counterclockwise, then ensures two neighboring taper
In valve two inclined-planes of mutual closing can just to being combined, i.e., one gradually to tilt from the inside, one for from
Outside slopes inwardly, then the two can be combined together just, so that being smooth to its inner surface and the outer surface after being combined
Arcwall face.
It is designed as bevel structure, the width for being equivalent to side broadens, then makes mutual closing in two neighboring conical lobe 31
When contact area increase, then divide petaloid syringe needle 3 be closed after, the bond strength between each conical lobe 31 is bigger, is showed
The puncture effect of acicular texture out is more preferable.Importantly, since side is designed as inclined-plane 105, so that two neighboring cone
Contact width when shape 31 mutual closing of valve increases, better tightness, therefore in the blood vessel in transmission process, it is not easy to make inside
Optical fiber light uniforming device 2 is disseminated, to influence final light out.
It is by taking pintongs conical lobe 31 as an example in the attached drawing 21-22 of the present embodiment, in fact, two valves, three valves are ok.
Embodiment 11
On the basis of any one of embodiment 8-10, in conical lobe 31, and 31 closing of adjacent conical valve or separate
Side or inclined-plane 105 be equipped with the first flexible layer so that the bonding strength more high leakproofness between conical lobe 31 is more preferable, sealing
Property more preferably can the liquid preferably in anti-hemostatic tube etc. pollute light uniforming device, and better tightness also can help to improve closure
Divide the intensity of petaloid syringe needle.
Preferably, the medial surface at the tip of the conical lobe is equipped with the second flexible layer so that taper when valvular structure being divided to be closed
It is higher by resultant force intensity between valve, better tightness.
The thickness of first flexible layer and the second flexible layer can be 0.005-0.04mm, the first flexible layer and the second flexible layer
Material can be polytetrafluoroethylene (PTFE), polyamide or polypropylene etc..
Embodiment 12
It is a kind of it is even go out light memory metal optical fiber puncture needle application, in human body it is intravascular walking, vascular wall puncture,
The puncture and the application in tumor photodynamic of intravascular obturator；The application method is as follows: temperature T0 can be 37 DEG C, temperature
Spending T1 can be 50 DEG C；
(1) needle tubing is punctured in optical fiber and stay in external one end connection acoustic vibration motor, due in temperature T0 (such as 37
DEG C), divide petaloid syringe needle to be closed, the light uniforming device of optical fiber is closed in point petaloid syringe needle, be then pierced into blood vessel, in the blood vessel into
Every trade is walked；
(2) when encountering the position wait pierce through, such as obturator or vascular wall, then it is pierced into wherein.
(3) when making optical fiber issue the light of certain wavelength to optical fiber connecting laser, such as logical 100mW wavelength swashs for 650nm
Light, then the temperature of light uniforming device increases, and temperature, which passes to a point petaloid syringe needle, increases its temperature also, when temperature reaches T1 (such as 50 DEG C)
When, divide petaloid syringe needle to open, light uniforming device 2 exposes, then light uniforming device can treat irradiated site and efficiently be irradiated.
If the optical fiber, which punctures needle tubing, to be used in photodynamic tumor-treatment, if interventional therapy is liver neoplasm, light
Fibre punctures needle tubing and enters liver artery by femoral artery puncture, finally enters blood vessel in liver neoplasm, laser is opened, temperature
It increases, petaloid syringe needle is divided to open, the light on light uniforming device is radiated at the tumour knurl for having injected photosensitive drug, keeps tumor intracorporal photosensitive
Drug (such as PHOTOFRINR) occurs photochemical reaction and generates necrosis and apoptosis that singlet oxygen then causes tumour knurl, thus
Achieve the purpose that treat tumour.
Light extraction efficiency of the invention is high, and light-out effect is good, and therapeutic efficiency is high.Using the optical fiber puncture needle in the present invention,
Intravascular walking is easy, is smooth, substantially can be within 10 minutes or left and right from femoral artery enters liver artery, finally enters liver
Intratumoral vasculature.The illumination efficiency of its optical fiber is high, light comprehensive utilization ratio is high, the illumination of same duration, the treatment rate of the application
Height has slit ratio not have the high 2-5% of its treatment rate of slit in rat experiment.In addition, the puncture needle in the present invention is also pierceable
The realizations such as vascular wall preferably across blood vessel walking etc..
The above description is only a preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For, the invention can have various changes and changes.All any modifications made within the spirit and principles of the present invention are equal
Replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of optical fiber puncture needle of even light out comprising optical fiber, it is characterised in that: the optical fiber includes main part, the main body
Portion is connect with the light uniforming device that can uniformly go out light；
The light uniforming device is the guiding device being made of tubular structure or club shaped structure, which includes that its inner wall has instead
The pipe sleeve of effect is penetrated, the side of the pipe sleeve is equipped with the slit that can go out inside and outside pipe sleeve and uniformly light；
The size of the slit are as follows: 1. slit width meets formula with length variationWherein, d (z) is slit
Width；L is the length of pipe sleeve；Z is the transmission direction along light, measures the slit length at certain point；R is the interior of guiding device
Diameter；Width by controlling slit can be such that the light of outgoing is uniformly distributed；
The periphery of the main part is enclosed with main body tube, and the periphery of the light uniforming device is enclosed with point petaloid being made of memory metal
Syringe needle, the heating under illumination effect of point petaloid syringe needle, which generates deformation, makes front end and side of the light of optical fiber from pipe sleeve to open
Slit project；This point of petaloid syringe needle is made of multiple conical lobes；
When temperature is T0, each conical lobe closure in point petaloid syringe needle being made of memory metal, this divides valve after being closed
Shape syringe needle is in cone shape structure, and is closed this point of petaloid syringe needle later and is wrapped in outside light uniforming device just；
When temperature is T1, each conical lobe in point petaloid syringe needle being made of memory metal is opened, the light uniforming device exposure
Outside so that light is uniformly exported from light uniforming device.
2. the optical fiber puncture needle of even light out according to claim 1, it is characterised in that: the structure of the guiding device are as follows:
The guiding device is the internal pipe sleeve with cavity, and light is transmitted by the reflection of pipe sleeve inner wall, and from slit uniformly
Output.
3. the optical fiber puncture needle of even light out according to claim 1, it is characterised in that: the structure of the guiding device can also
It is enough are as follows: the guiding device includes transparent rods and pipe sleeve, and the pipe sleeve is sleeved on outside transparent rods, and light is under the reflex of pipe sleeve
It transmits along transparent rods, and is uniformly exported from the slit of pipe sleeve.
4. the optical fiber puncture needle of even light out according to claim 1, it is characterised in that: the optical fiber further includes head, institute
The rear end for stating head is connect with main part, and the front end on head is equipped with the light uniforming device；
The head is wrapped with metal-coating；The metal-coating is equipped with dentalation so that its resistance when advancing is small
Resistance is big when retrogressing, to effectively reduce the thrust for puncturing and needing.
5. it is according to claim 3 it is even go out light optical fiber puncture needle, it is characterised in that: the length of the guiding device is
5mm-20mm, the internal diameter of guiding device are 0.1-2mm；
The pipe sleeve inner wall has polishing and/or metal-plated membrane layer so that its inner wall light transmissioning efficiency is promoted；
The transparent rods are that club shaped structure is constituted using transparent material, and the transparent material includes quartz or polymer；It is described
The refractive index of bright stick is 1.5；
The main body tube is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is to form helical form using laser cutting to cut
The helical structure of seam；The length of main body tube is 1-2m.
6. the optical fiber puncture needle of even light out according to claim 2 or 3, it is characterised in that: the inner wall of the pipe sleeve is tool
The reflective type inner wall or first polishing treatment for having metallic diaphragm reflector are coated with the metallic diaphragm with reflecting effect again；
The shape of the slit includes bar shaped, helical form or hole shape, and the slit of described hole shape is made of multiple holes
Bar shaped or spiral helicine slit.
7. the optical fiber puncture needle of even light out according to claim 1, it is characterised in that: the outgoing transmitance of the slit is full
Sufficient formula is 2.Wherein, T (z) is the transmitance that light is emitted out of slit at z.
8. the optical fiber puncture needle of even light out according to claim 7, it is characterised in that: when transmitance T (z) < 1, slit at z
Width and formula 1. in d (z) equivalent width；
As transmitance T (z) > 1, the width of slit needs to be repaired on the basis of formula 1. middle calculating resulting d (z) at z
Just.
9. a kind of production method of slit, which is characterized in that the production method of slit described in any one of claim 1-8
Are as follows: it is capable of the slit of even light out, the slit by machining or lithographic method production on the guiding device of tubulose
Width d meet claim 1 formula and 1. calculate resulting width, by slit obtained by this method, light is saturating everywhere
It is almost the same to cross rate.
10. a kind of production method of light uniforming device, which is characterized in that the method are as follows: if A. guiding device is in claim 2
The pipe sleeve, then preparation method are as follows: prepare pipe sleeve as described in claim 2, then production can be even on pipe sleeve
The slit of light out；If B. guiding device is structure described in claim 3, preparation method are as follows: described in preparing
Transparent rods, then high reflecting metal film is plated by plated film mode outside transparent rods and constitutes reflection-type light guide structure, the metal plated
Film constitutes the pipe sleeve of metal material.
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| CN201811332047.2A CN109603010B (en) | 2018-11-09 | 2018-11-09 | A kind of preparation method of even the optical fiber puncture needle of light and slit and light uniforming device out |
| PCT/CN2019/074254 WO2020093616A1 (en) | 2018-11-09 | 2019-01-31 | Optical fiber puncture needle capable of uniformly emitting light, and method for preparing slit and light homogenizer |
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| CN201811332047.2A CN109603010B (en) | 2018-11-09 | 2018-11-09 | A kind of preparation method of even the optical fiber puncture needle of light and slit and light uniforming device out |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN203107075U (en) * | 2013-03-01 | 2013-08-07 | 重庆医科大学 | Visual puncturing system |
| CN105520783A (en) * | 2015-11-30 | 2016-04-27 | 李昭中 | High-temperature vaporizing tumor therapy equipment |
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| US7274847B2 (en) * | 2004-11-16 | 2007-09-25 | Biotex, Inc. | Light diffusing tip |
| TWI442111B (en) * | 2011-05-23 | 2014-06-21 | Kinpo Elect Inc | Light guide element, light module and display |
| CN202843727U (en) * | 2012-02-15 | 2013-04-03 | 浙江海洋学院 | Angle variable tine bifurcating needle core |
| CN108143469B (en) * | 2016-12-02 | 2020-05-26 | 潘湘斌 | Puncture sheath |
| CN106963992B (en) * | 2017-03-22 | 2019-02-22 | 尚华 | A kind of marmem hypotube and its application in blood vessel optical fiber seal wire |
| CN107376132B (en) * | 2017-07-17 | 2020-02-04 | 尚华 | Novel optical fiber catheter and preparation method thereof |
| CN108671415B (en) * | 2018-05-22 | 2020-11-10 | 西安雅泽泰克医疗科技有限公司 | Medical optical fiber and laser therapeutic apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203107075U (en) * | 2013-03-01 | 2013-08-07 | 重庆医科大学 | Visual puncturing system |
| CN105520783A (en) * | 2015-11-30 | 2016-04-27 | 李昭中 | High-temperature vaporizing tumor therapy equipment |
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