CN109331346B - A kind of memory metal optical fiber puncture needle tubing - Google Patents
A kind of memory metal optical fiber puncture needle tubing Download PDFInfo
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- CN109331346B CN109331346B CN201811364074.8A CN201811364074A CN109331346B CN 109331346 B CN109331346 B CN 109331346B CN 201811364074 A CN201811364074 A CN 201811364074A CN 109331346 B CN109331346 B CN 109331346B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N2005/0612—Apparatus for use inside the body using probes penetrating tissue; interstitial probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
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Abstract
The present invention relates to a kind of memory metal optical fiber to puncture needle tubing comprising optical fiber, the optical fiber include main part and head, and the head includes straight type head and bores the drawing conehead that the diameter that technique is formed is tapered using drawing；The periphery of the main part is enclosed with main body tube, the straight type head is wrapped with metal-coating, the periphery for drawing conehead is enclosed with point petaloid syringe needle being made of memory metal, and the metal-coating is fixedly connected with a point petaloid syringe needle, and described point of petaloid syringe needle is made of multiple conical lobes.The puncture needle tubing passes through the mutual synergistic effect of all parts, can be realized the purpose transmitted in long blood vessel faster, as can smoothly walking nearly 2 meters of length of vessel；And can be realized higher light extraction efficiency and therapeutic effect, there is important application value and meaning in photodynamic tumor-treatment.And the puncture needle tubing can also be applied in other fields, such as eliminate blood vessel occlusion or carry out vascular puncture.
Description
Technical field
The present invention relates to a kind of the field of medical instrument technology, and in particular to a kind of memory metal optical fiber puncture needle tubing.
Background technique
Photodynamic therapy (Photodynamic Therapy, PDT) is to carry out medical diagnosis on disease using photodynamic effect and control
A kind of new technology treated.Its exposure basis is photodynamic effect.This is a kind of light of adjoint biological effect for having oxygen molecule to participate in
Sensitized reaction.Its process is that the laser irradiation of specific wavelength excites the photosensitizer of tissue resorption, and excitation state is photosensitive
Agent generates highly active singlet oxygen, oxygen occurs for singlet oxygen and adjacent large biological molecule again energy transmission to the oxygen of surrounding
Change reaction, generates cytotoxic effect, and then lead to cell damage or even death.Compared to traditional remedies, photodynamic therapy has
Wound is small, targeting is good, without drug resistance and the advantages of toxic side effect.But since the main wavelength of photodynamic therapy concentrates on more than 600
The red spectral band of nanometer, this wave band is big in the loss of people's body absorption, can only generally transmit several millimeters to tens of milliseconds magnitude, for
Some deep tumors can not play the role of effective optical dynamic therapy.By optical fiber, endoscope and other interventional techniques, can incite somebody to action
Laser aiming is treated to internal deep, the wound and pain caused by operation such as avoids out chest, opens abdomen.It uses and contains at present
The puncture needle of optical fiber can introduce light into vivo, but due to needing to export light from optical fiber, needle point needs to have sufficiently large
Small hole increases the diameter of syringe needle so that light appears.To overcome penetration Resistance, optical fiber is wrapped up by hard metal material,
Needle tubing is thicker, needs to make its puncture using very big pressure in puncture process, be easy to cause biggish wound, destroy normal blood
Tubing causes bleeding.Therefore, in response to this series of problems, the application has studied a kind of memory metal optical fiber puncture needle tubing.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of memory metal optical fiber to puncture needle tubing, solve in the prior art
Existing deficiency.
The purpose of the present invention is be achieved through the following technical solutions:
A kind of memory metal optical fiber puncture needle tubing comprising optical fiber, the optical fiber include main part and head, the head
Including straight type head and the drawing conehead being tapered using the diameter for drawing cone technique to be formed；The periphery of the main part is enclosed with main body
Pipe, the straight type head are wrapped with metal-coating, and the periphery for drawing conehead is enclosed with point petaloid needle being made of memory metal
Head, the metal-coating are fixedly connected with a point petaloid syringe needle, and described point of petaloid syringe needle is made of multiple conical lobes；
When temperature is T0, each conical lobe closure in point petaloid syringe needle being made of memory metal, closure later should
Dividing petaloid syringe needle is in cone shape structure, and is closed this point of petaloid syringe needle later and is wrapped in outside the drawing conehead of optical fiber just；
When temperature is T1, each conical lobe in point petaloid syringe needle being made of memory metal is opened, the optical fiber
Drawing conehead to be exposed to outside, allow it to will be on light direct irradiation to tumour.Further, the metal-coating is equipped with
Dentalation so that its when advancing, resistance is big when resistance small retrogressing, to effectively reduce the thrust for puncturing and needing.
Further, the main body tube is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is to be cut using laser
Cut the helical structure to form helical form joint-cutting；The length of main body tube is 1-2m.
Further, the metal-coating tight is in the periphery in fiber body portion so that optical fiber is connected with metal-coating
It is integrated, the metal-coating is the structure that spiral helicine metal-coating or its outer surface are equipped with joint-cutting, if spiral helicine
Metal-coating, then metal-coating is to carry out laser cutting on metal tube to form the helical structure of helical form joint-cutting to make it have
Some strength increases certain flexibility simultaneously；
Further, the conical lobe is that each equal curvature of point is consistent thereon, the conical lobe that is made of arcwall face.
Further, the shapes and sizes of all conical lobes are consistent.
Further, the pawl shape knot that the sheet metal of the metal-coating is less than the thickness of rear end for the thickness of front end is constituted
Structure is so that optical fiber puncture needle more easily walks forward and is not easy to retreat；
Further, the optical fiber puncture needle stays in external one end and is connected with the power device for being able to carry out front and back vibration
So that it can give one forward pressure of optical fiber puncture needle while vibration.
Further, the power device is acoustic vibration motor, and the front and back Oscillation Amplitude of the power device is 10um-
500um, vibration frequency 10Hz-1000Hz.
Further, when being emitted in optical fiber without light, the temperature of point petaloid syringe needle transmitted in vivo is T0, divides petaloid
Each conical lobe in syringe needle closes up for needle-shaped or cone shape；When optical fiber has light outgoing, since the fuel factor of optical fiber makes
Point petaloid syringe needle temperature after being illuminated by the light being made of memory metal gradually rises as T1, then divides each taper in petaloid syringe needle
Valve is opened, and the exposed light made on optical fiber of drawing conehead of optical fiber is directly projected from open point petaloid syringe needle.
Further, the main part packet for preventing the light in optical fiber from projecting from side is coated with outside the main part of the optical fiber
Layer；It is 1.45-1.55 that optical fiber, which draws the refractive index of conehead,.
Further, the cone angle beta for drawing conehead 2 is 7-25 °.
Further, temperature T0 is 37 DEG C, and temperature T1 is 50 DEG C；It is made as closed in advance in temperature T0 time-division petaloid syringe needle
Shape, when temperature is T1, each conical lobe in point petaloid syringe needle is made as opening shape in advance；When puncturing, not light passing in optical fiber,
Dividing petaloid syringe needle temperature is T0, and closure realizes transmission puncture；After being punctured to the predetermined area, laser is led in optical fiber, optical fiber draws cone
In light radiation to memory metal on head, temperature is increased to T1 or more, and petaloid syringe needle is divided to open.
Further, the length on the head is 7-10mm, wherein the length for dividing petaloid syringe needle is 2.5-4mm；Institute
The length for stating metal-coating is 4.5-6mm.
Further, in metal-coating, the width a of joint-cutting is 0.1-0.2mm, constitutes the helical structure of metal-coating
The width of sheet metal is 0.2-1mm；In dentalation, sheet metal front end with a thickness of 50-70 μm, the thickness of sheet metal rear end
Degree is 90-110 μm, and the thickness difference of front-end and back-end is 30-50 μm.
Further, described point of petaloid syringe needle includes tail end and tip, and the conical lobe is by its width of tail end to tip
It is sequentially reduced, when each conical lobe closure, the diameter of tail end is greater than the diameter at tip；The tail end of each conical lobe integrally connects
The annular ring for foring cirque structure is connect, which is fixedly connected with metal-coating.
Further, when each conical lobe is closed, close to each other two side in two neighboring conical lobe is close
Closing, this point of petaloid syringe needle constitute totally enclosed cone shape structure.
Further, in the conical lobe, for being inclined-plane with the closing of adjacent conical valve or the side separated, and it is all
Bevel direction in conical lobe is consistent.
The present invention provides a kind of memory metal optical fiber to puncture needle tubing, main to have the beneficial effect that the puncture needle tubing is logical
The mutual synergistic effect for crossing all parts, can be realized the purpose transmitted in long blood vessel faster, as can smoothly wearing
It is about to nearly 2 meters of length of vessel；And can be realized higher light extraction efficiency and therapeutic effect, have in photodynamic tumor-treatment
Important application value and meaning.And the puncture needle tubing can also be applied in other fields, such as eliminate blood vessel occlusion or into
Row vascular puncture etc..
The present invention cleverly uses the characteristic of memory metal, and creative with fuel factor etc. that is walking temperature, light in vivo
It being combined, realizes in transmission process, optical fiber head is protected, and a point petaloid syringe needle for closure can also be punctured,
It is stronger to be conducive to across blood vessel walking, practicability during walking；And by the heating effect of light, so that valve will be divided in illumination
Shape syringe needle is opened, and so that the light in optical fiber is shone directly into purpose position and is realized treatment etc..And it is drawn by using optical fiber head
Cone technique forms the increasingly thinner drawing conehead of diameter and is conducive to illumination and photosensitizer so that effective exposure rate of light greatly promotes
Effective cooperation, the waste for reducing light or photosensitizer reduces cost to increase therapeutic effect.In addition, the present invention is drawing conehead
It can also carry out going out light on a small quantity simultaneously from metal-coating joint-cutting while light out, then assist that conehead is drawn to realize to entire tumour etc.
Effective treatment at position.
Then the present invention cooperates vibrating motor by designing pawl shape structure outside metal-coating, realize advance it is convenient,
It is not easy the effective transmission retreated, is conducive to smoothly walk in the blood vessel.And the specific structure setting of metal-coating can not only
Proof strength and flexibility are just their ability to cooperate and regular can smile with vibrating motor there are one important function
Deformation helps to move ahead in the blood vessel.
Generally speaking, clinical good application effect, it is practical, there is biggish application value.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of optical fiber puncture needle tubing when point petaloid syringe needle described in the embodiment of the present invention is closed；
Fig. 2 is the structural schematic diagram of head end when point petaloid syringe needle described in the embodiment of the present invention is opened；
Fig. 3 is the structural schematic diagram for the head end that optical fiber described in the embodiment of the present invention punctures needle tubing；
Fig. 4 is the sectional view for the head end that optical fiber described in the embodiment of the present invention punctures needle tubing；
Fig. 5 is structural schematic diagram when point petaloid syringe needle described in the embodiment of the present invention is opened；
Fig. 6 is structural schematic diagram when point petaloid syringe needle described in the embodiment of the present invention is closed；
Fig. 7 is the partial structure diagram of spiral helicine metal-coating described in the embodiment of the present invention；
Fig. 8 is that optical fiber described in the embodiment of the present invention punctures malformation signal of the needle tubing under the driving of vibrating motor
Figure；
Fig. 9 is Temperature Distribution schematic diagram when a point petaloid syringe needle described in the embodiment of the present invention has light irradiation；
Figure 10 is the structural schematic diagram of the outer surface of metal-coating described in the embodiment of the present invention 3；
Figure 11 is the structural schematic diagram of the outer surface of metal-coating described in the embodiment of the present invention 3；
Figure 12 is the section structural schematic diagram (seeing from inside to outside) of main body tube described in the embodiment of the present invention；
Figure 13 is the cross-sectional structure signal for the main body tube being wrapped in outside fiber body portion described in the embodiment of the present invention
Figure；
Figure 14 is cross-sectional view when point petaloid syringe needle described in the embodiment of the present invention 5 is closed together；
Figure 15 is cross-sectional view when point petaloid syringe needle described in the embodiment of the present invention 5 is opened；
Figure 16 is the range schematic diagram that the light emission on drawing conehead described in the embodiment of the present invention 4 goes out；
Figure 17 is the emergent light spot schematic diagram that conehead is drawn described in the embodiment of the present invention.
In figure, straight type head 1 draws conehead 2, divides petaloid syringe needle 3, metal-coating 4, main part 8, main body tube 9, conical lobe 31,
Annular ring 32, tip 33, tail end 34, sheet metal 41, joint-cutting 42, inclined-plane 105, overcoat polymer 106, hydrophilic coating 107.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
It is a part of the embodiment of the present invention, instead of all the embodiments.The detailed description of the embodiment of the present invention presented below is simultaneously
It is not intended to be limiting the range of claimed invention, but is merely representative of selected embodiment of the invention.Based in the present invention
Embodiment, this field commonsense method personnel every other embodiment obtained without creative efforts,
It shall fall within the protection scope of the present invention.
Embodiment 1
A kind of memory metal optical fiber puncture needle tubing, shown in 1-4 comprising optical fiber, the optical fiber include main part 8 and head
Portion, the head include straight type head 1 and bore the drawing conehead 2 that the diameter that technique is formed is tapered, one end of straight type head 1 using drawing
Be fixedly connected or be integrally formed with 8 integrally connected of main part, the other end with draw conehead larger diameter end be fixedly connected or one at
Type.
The periphery of the main part 8 is enclosed with main body tube 9, and the straight type head 1 is wrapped with metal-coating 4, the metal
4 tight of housing is in the periphery of straight type head 1 so that the straight type head 1 and metal-coating 4 of optical fiber are connected as one；The drawing conehead
2 periphery is enclosed with point petaloid syringe needle 3 being made of memory metal, divide petaloid syringe needle illumination effect under heating generate deformation and
Opening appears the light of optical fiber；The metal-coating 4 is fixedly connected with point tail end of petaloid syringe needle 3 or larger diameter end, and described point
Petaloid syringe needle 3 is made of multiple conical lobes 31, as seen in figs. 5-6；The head of optical fiber and the metal-coating 4 outside head and divide petaloid
Syringe needle 3 can be collectively referred to as head end.
When temperature is T0, as shown in figs. 1 and 3, each conical lobe 31 in point petaloid syringe needle 3 being made of memory metal
Closure, this divides petaloid syringe needle 3 to be in cone shape structure after being closed, and this point of petaloid syringe needle 3 is wrapped in light just after closure
Outside fine drawing conehead 2；Optical fiber is wrapped in point valvular structure, protects optical fiber, and during walking in the blood vessels, cone
Type divides valvular structure is convenient to walk in the blood vessel, and advance resistance is small, and backing resistance is big, convenient to move ahead.
When temperature is T1, as shown in Fig. 2, each conical lobe 31 in point petaloid syringe needle 3 being made of memory metal is beaten
It opens, then the drawing conehead 2 of the optical fiber is exposed to outside allow it to will be on light direct irradiation to tumour.
There is dentalation, as shown in Figs 1-4, such structure has very little resistance when advancing on the metal-coating 4
Power, when retreating, resistance is larger, so as to be punctured, effectively reduced in a manner of progressive to apply in a manner of weak impact
Puncture the pressure needed.
As further preferred embodiment, as shown in Figs 1-4, the metal-coating is spiral helicine metal-coating,
The metal-coating is to carry out laser cutting on metal tube to form the helical structure of helical form joint-cutting to make it have some strength
Increase certain flexibility simultaneously.
As further preferred embodiment, picture 1-4, shown in 7, the sheet metal 41 of metal-coating 4 is constituted in front end
Thickness be less than rear end thickness fall dentalation so that optical fiber puncture needle more easily walks forward and is not easy to retreat.
It is highly preferred that being not easy to indicate its thickness in the accompanying drawings as shown in fig. 7, the thickness c due to sheet metal front end is too thin
Degree, therefore the position of c is only denoted in attached drawing, do not provide its thickness relationship.In falling in dentalation for metal-coating 4, i.e. structure
In structure of the thickness less than the thickness of rear end at the front end of the sheet metal of metal-coating, the thickness c of sheet metal front end is 50-70
μm, the thickness d of sheet metal rear end is 90-110 μm, and the thickness difference of front-end and back-end is 30-50 μm.The control of the thickness for
Effectively smoothly transmission is advanced important, and thickness difference is too big then or to be will increase metal-coating outer diameter or need to reduce gold
The internal diameter for belonging to housing, then be affected to integrated piercing needle tubing, and thickness difference is big, the thickness of sheet metal trailing flank increase compared with
Greatly, it will increase whole advance resistance instead, and for minute blood vessel, also will increase the degree of injury to blood vessel.
If if thickness difference is too small, not having helps to advance, prevents that falls back most to use.
It is highly preferred that in metal-coating 4, as shown in fig. 7, the width a of joint-cutting is 0.1-0.2mm, as 0.1mm,
0.15mm, 0.2mm etc., constitute the sheet metal of helical structure width b be 0.2-1mm, as 0.2mm, 0.4mm, 0.6mm,
0.8mm, 1mm etc.；The width a of joint-cutting and the data of width b of sheet metal and the matching relationship of the two directly affect energy
It is no to pass through blood vessel and the smoothness across blood vessel, but also affect the piercing that another blood vessel is penetrated into from a blood vessel
Intensity.Width a and width b it is too wide it is too narrow can all affect its flexibility and intensity, intensity can not then pass through by force very much blood vessel
Knee, and it is very big to the injury tolerance of blood vessel；It is flexible too strong, then it can not pass through the longer blood vessel of length, the length within 1 meter
Degree is easier to, but 1 meter or more of blood vessel is difficult across and user bad control and direction in vitro, from a blood vessel
When penetrating into another blood vessel, due to the too low also bad puncture of intensity, the too strong and flexible too intensity of intensity cannot achieve
Up in the blood vessel or organ of depth into the human body, in liver neoplasm.Only suitable width a cooperates the suitable width side b can
Realize good effect.
As further preferred embodiment, the optical fiber, which punctures needle tubing and stays in external one end and be connected with, to be able to carry out
The power device of front and back vibration is so that it can puncture one forward pressure of needle tubing to optical fiber while vibration.
The power device is preferably acoustic vibration motor, and the front and back Oscillation Amplitude of the power device is 10um-500um,
Vibration frequency is 10Hz-1000Hz.
Such as: when puncturing, needle tubing will be punctured and connect acoustic vibration motor, vibration frequency 100Hz, Oscillation Amplitude is
50um.As shown in figure 8, in puncture needle tube vibration, puncture needle tubing overall structure deformation occurs conduction vibration, when vibration forward when
Miniature deformation occurs for puncture needle, as shown in A, the contraction of screw pitch, the elasticity in bending and metal-coating 4 including puncturing needle tubing
Deformation promotes needle point to travel forward, and resistance is overcome to puncture forward；When vibrating backward, as indicated atb, since metal-coating 4 has
There is down dentalation, much larger than travelling forward, needle point tends to motionless and puncture needle tubing is pulled integrally to travel forward frictional force.?
Under the action of repeatedly vibrating while applying extra pressure, punctures needle tubing and continue to puncture forward.Apply pressure needed for such puncture mode
Power is less than traditional puncture needle, therefore it is thinner more soft to allow optical fiber puncture needle, while can complete to puncture effect.
As further preferred embodiment, when being emitted in optical fiber without light, i.e., laser and optical fiber puncture needle tubing
External one end connection, when laser is not turned on, the temperature of point petaloid syringe needle transmitted in vivo is T0, is divided in petaloid syringe needle
Each conical lobe closes up for needle-shaped or cone shape；When optical fiber has light outgoing, i.e., the laser opening connecting with optical fiber makes light
After being transferred to optical fiber, due to the fuel factor of optical fiber, i.e., when light is emitted by conical fiber and is radiated on memory metal, so that by
Point temperature after being illuminated by the light of petaloid syringe needle 3 that memory metal is constituted gradually rises as T1, then divides each taper in petaloid syringe needle
Valve is opened, that is, is more than its phase transition temperature and is generated outside prefabricated deformation, is in open shape；Light is emitted by opening, i.e. the drawing of optical fiber
The exposed light made on optical fiber of conehead is directly projected from open point petaloid syringe needle.
Temperature T0 can be 37 DEG C, and temperature T1 can be 50 DEG C；Such as: at temperature T0 (such as 37 DEG C), petaloid syringe needle 3 will be divided
Be made as in advance it is close-shaped, temperature be T1 (such as 50 DEG C) when, point petaloid syringe needle 3 in advance is made as open shape.Then puncture in vivo
When, light passing, head do not divide 3 temperature of petaloid syringe needle to be body temperature T0 (37 DEG C) in optical fiber, and point closure of petaloid syringe needle 3 realizes that transmission is worn
Thorn.Leading to 100mW wavelength after being punctured to the predetermined area, in optical fiber is 650nm laser, draws conehead to be radiated by remembering by optical fiber
What metal was constituted divides on petaloid syringe needle 3；As shown in figure 9, Fig. 9 is that have 500W/ (m2.K) convection current in the outside on puncture needle head
Thermally conductive situation (the typical rate of heat dissipation of liquid convection), temperature can be increased to 70.5 DEG C under 100mW laser action, more than T1 temperature
(50 DEG C) generate deformation and open.
As further preferred embodiment, the conical lobe 31 be thereon each equal curvature of point it is consistent, by arc
The conical lobe that face is constituted then makes entirety walk effect more preferable.
The shapes and sizes of all conical lobes 31 are consistent, then the power being distributed on each conical lobe 31 is more evenly, whole
Physical strength degree is bigger.
Divide and contains 2-5 conical lobe, preferably 2 conical lobes or 3 conical lobes in valvular structure；Valve number then each cone too much
Shape valve is too small, and intensity is inadequate.
As further preferred embodiment, the length on the head is 7-10mm, wherein described to divide petaloid syringe needle 3
Length L be 2.5-4mm.Such as 3mm；The length l of the metal-coating 4 or straight type head 1 is 4.5-6mm, such as 5mm；Such as Fig. 1 and 6
It is shown.Point petaloid syringe needle 3 or conical lobe 31 with a thickness of 0.06-0.12mm.When its closure, it is wrapped in just and draws conehead 2
Outside, preferably draw conehead 2 and divide it is seamless between petaloid syringe needle, then draw conehead 2 for point petaloid syringe needle 3 have auxiliary increase
The effect of its strong intensity, then cooperate the conical lobe 31 of specific thicknesses, be conducive to transmission, the piercing etc. that puncture needle tubing, there is synergy
Effect.
As further preferred embodiment, drawing the diameter at the most advanced place of conehead is 10-50 μm, such as 20 μm, 30 μm, 40
μm。
As further preferred embodiment, the length of the main body tube 9 is 1-2m, such as 1.8m, fiber body portion 8 with
The length of main body tube 9 is consistent, and main body tube tight is outer in the main part 8 of optical fiber so that the two is integrally formed, and facilitates transmission.
The diameter of the main part 8 of optical fiber and straight type head 1 can be 400 μm, can be silica fibre, 4 He of metal-coating
The outer diameter of main body tube 9 can be 600 μm, and internal diameter can be 400 μm.
It is described that petaloid syringe needle 3 is divided to include tail end 34 and tip 33 as further preferred embodiment, as shown in fig. 6,
The conical lobe 31 is that its width is sequentially reduced by tail end to tip, when each conical lobe 31 closure, the diameter of tail end 34
Greater than the diameter at tip 33；The tail end integrally connected of each conical lobe forms the annular ring 32 of cirque structure, the annular ring
32 are fixedly connected with metal-coating 4.
Phase as further preferred embodiment, when each conical lobe 31 closure, in two neighboring conical lobe 31
Mutually two close close closings in side, this divides valvular structure to constitute totally enclosed cone shape structure, preferably protects light
Fine drawing conehead draws conehead to be contaminated in transmission process, influences the later period and goes out the exposure rate of light, to will affect tumor locus
The effect of upper photosensitizer.
In the present embodiment, it in use, head one end is pierced into blood vessel first, then transmits in the blood vessel, puncture needle
External one end of pipe can connect vibrating motor, assist puncture needle tubing to reach predetermined position by blood vessel, such as intracorporal tumour (such as liver
Dirty tumour) it is medium.
Embodiment 2
On the basis of embodiment 1, the main body tube 9 is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is
The helical structure of helical form joint-cutting is formed using laser cutting.
As shown in figure 12, based on Figure 12 pipe section schematic diagram, and be the view seen from inside to outside from main body tube；The master
In body pipe 9, the width a of joint-cutting is 0.02-0.2mm, such as 0.05mm, 0.1mm, 0.15mm, constitutes helical structure in body pipe 9
The width d of flight is 0.5-3mm, such as 1mm, with a thickness of 0.05-0.1mm, such as 0.08mm.Nearly 2 meters of the length of main body tube 9,
It, which penetrates human body, usually just a 1-1.8m, and human vas thickness it is different, there are also certain curvature, such long distance, such as
This special vascular environment, it is very high to its intensity and flexibility requirements, therefore the width d of the width a of joint-cutting, flight and its thickness
Can the data and matching relationship of degree directly affect pass through blood vessel and the smoothness across blood vessel, or even have an effect on head
The intensity of portion's piercing tumor vessel wall.Width a and width d it is too wide it is too narrow can all affect its flexibility and intensity, only close
Suitable width a cooperates the suitable width side d that can realize good effect.
The main body tube 9 is biomedical metallic material, and including but not limited to stainless steel, synthetic fibers, carbon fiber, titanium close
One of gold, Jin Heyin, preferably stainless steel, see on the whole, which wrapped up simultaneously by a stainless steel wire in fact
It is helically wound around the wrapping wire layer of 8 periphery of main part of optical fiber, can also be two or more wrapping wire windings certainly.
As illustrated by figs. 12-13, the main body tube 9 is externally provided with overcoat polymer 106 to increase the leakproofness of main body tube 9 and subtract
Slight drag；The material of overcoat polymer 106 can be polyamide or polypropylene etc., and other many polymer are ok.It is described poly-
The outside for closing beyond the region of objective existence set 106 is coated with hydrophilic coating 107 to increase blood compatibility.The hydrophilic coating 107 is using chemistry
Stable material is made, including but not limited to polytetrafluoroethylene (PTFE), silicon rubber, polyethylene, polyvinyl chloride, fluorocarbon polymer and poly- ammonia
Ester.Hydrophilic coating is coated, reduces resistance in the blood vessel, the long blood vessel of interior environment complexity can be passed through.
Hydrophobic coating substitution can be used in hydrophilic coating 107 in the present embodiment.
Embodiment 3
Metal-coating 4 or its outer surface are equipped with the structure of multiple joint-cuttings 42 in embodiment 2, such as Figure 10-11 institute
Show, i.e. the joint-cutting 42 in the outer surface of metal tube laser cutting wedge shape, i.e., the inclined direction of joint-cutting 42 is to tilt backwards, such as
Shown in Figure 10, the width of joint-cutting 41 is by lateral surface one end to close to medial surface one end, and thickness successively reduces.
Preferably, the metal-coating 4 in the present embodiment can be for by tail end to front end, i.e., its diameter be sequentially reduced from back to front
Structure, facilitate advance, as shown in figs. 10-11.
Embodiment 4
On the basis of embodiment 2, optical fiber draws the refractive index of conehead 2 for 1.45-1.55, and preferably 1.5, then draw conehead 2
Cone angle beta be 7-25 °, as shown in figure 4, can guarantee substantially draw conehead go out light be to emit light within the scope of 60-120 °, angle
Degree is as shown in the α in Figure 16.Specifically, by optical analog it is found that cone angle beta be 22 °, then the angle of divergence alpha of light within 120 °,
If cone angle beta is 7.6 °, the angle of divergence alpha of light is within 60 °.Therefore, it when drawing the cone angle beta of conehead 2 to be 7-25 °, draws on conehead
Light can effective directive destination locations, in such as tumour containing photosensitizer, then can efficiently use luminous energy, greatly increase out
Light rate.
The refractive index of entire optical fiber can be 1.5, it is preferable, however, that being coated with covering, the refractive index of covering outside fiber body portion 8
It lower than optical fibre refractivity, such as can be 1.2,1.3, so that the light in the main part 8 of optical fiber will not be projected from main part, constrain
Light issue light can only from head, facilitate light direct irradiation to the tumour containing photosensitizer.The main component of the covering is usual
It is also silica, referring specifically to the prior art.
It is preferred that outside the straight type head of the optical fiber at spiral sleeve, i.e. optical fiber at the joint-cutting of spiral sleeve 1 without package covering or
The refractive index of covering type head 1 more straight than optical fiber is smaller, then can by a part light pass through spiral sleeve joint-cutting at carry out out light, reality
Now to the irradiations at other auxiliary positions, then effectively to be irradiated by drawing conehead to attack keypoint part directly, straight type head 1 is to extension
Position carries out auxiliary irradiation, realizes effective irradiation to whole position to be illuminated, such as irradiates the tumor tissues containing photosensitizer,
The drug effect that photosensitizer can be effectively increased plays, and finally increases its therapeutic effect.
In the present embodiment, Fig. 9 is the optical transmission property simulation that optical fiber draws cone, if a length of 650nm of input optical fibre light wave,
When input power is 1W, drawing conehead outgoing optical power from optical fiber is 0.94W, and emergent power is very high, and the angle of divergence is about 60 degree,
Effectively it can be irradiated or be treated for keypoint part；Light spot shape is as shown in figure 17.
Embodiment 5
In embodiment 1-4 any one on the basis of, as shown in figs. 14-15, in conical lobe 31, be used for and adjacent cone
The closing of shape valve or separated side are inclined-plane 105, i.e. there are two sides for a conical lobe 31, and each side is bevel structure.
And 105 direction of inclined-plane in all conical lobes 31 is consistent, i.e., it is consistent by direction clockwise or counterclockwise, then it ensures adjacent
Two inclined-planes of mutual closing can be just to being combined in two conical lobes, i.e., one is gradually to tilt from the inside,
One for externally to tilted, then can both be combined together, so as to its inner surface and the outer surface after being combined just
It is smooth arcwall face.
It is designed as bevel structure, the width for being equivalent to side broadens, then makes mutual closing in two neighboring conical lobe 31
When contact area increase, then divide petaloid syringe needle 3 be closed after, the bond strength between each conical lobe 31 is bigger, is showed
The puncture effect of acicular texture out is more preferable.Importantly, since side is designed as inclined-plane 105, so that two neighboring cone
Contact width when shape 31 mutual closing of valve increases, better tightness, therefore in the blood vessel in transmission process, it is not easy to make inside
Optical fiber draws conehead 2 to be disseminated, to influence final light out.
It is by taking pintongs conical lobe 31 as an example in the attached drawing 14-15 of the present embodiment, in fact, two valves, three valves are ok.
Embodiment 6
On the basis of any one of embodiment 1-5, in conical lobe 31, and adjacent conical valve 31 closing or separate
Side or inclined-plane 105 are equipped with the first flexible layer so that the bonding strength more high leakproofness between conical lobe 31 is more preferable, leakproofness
More preferably can the liquid pollution preferably in anti-hemostatic tube etc. draw conehead, and better tightness also can help to improve point of closure
The intensity of petaloid syringe needle.
As further preferred embodiment, the medial surface at the tip of the conical lobe is equipped with the second flexible layer so as to divide
It is higher by resultant force intensity between conical lobe when valvular structure is closed, better tightness.
The thickness of first flexible layer and the second flexible layer can be 0.005-0.04mm, the first flexible layer and the second flexible layer
Material can be polytetrafluoroethylene (PTFE), polyamide or polypropylene etc..
Embodiment 7: application
A kind of memory metal optical fiber punctures the application of needle tubing, and intravascular walking, vascular wall puncture, are intravascular in human body
The puncture and the application in tumor photodynamic of obturator；The application method is as follows: temperature T0 can be 37 DEG C, and temperature T1 can
It is 50 DEG C；
(1) needle tubing is punctured in optical fiber and stay in external one end connection acoustic vibration motor, due in temperature T0 (such as 37
DEG C), divide petaloid syringe needle to be closed, the drawing conehead of optical fiber is closed in point petaloid syringe needle, be then pierced into blood vessel, in the blood vessel into
Every trade is walked；
(2) when encountering the position wait pierce through, such as obturator or vascular wall, then it is pierced into wherein.
(3) when making optical fiber issue the light of certain wavelength to optical fiber connecting laser, such as logical 100mW wavelength swashs for 650nm
Light then draws the temperature of conehead to increase, and temperature, which passes to a point petaloid syringe needle, increases its temperature also, when temperature reaches T1 (such as 50 DEG C)
When, divide petaloid syringe needle to open, draws conehead 2 to expose, then draw conehead that can treat irradiated site and efficiently irradiated.
If the optical fiber, which punctures needle tubing, to be used in photodynamic tumor-treatment, if interventional therapy is liver neoplasm, light
Fibre punctures needle tubing and enters liver artery by femoral artery puncture, finally enters blood vessel in liver neoplasm, laser is opened, temperature
It increases, petaloid syringe needle is divided to open, draw the light on conehead to be radiated at the tumour knurl for having injected photosensitive drug, keep tumor intracorporal photosensitive
Drug (such as PHOTOFRINR) occurs photochemical reaction and generates necrosis and apoptosis that singlet oxygen then causes tumour knurl, thus
Achieve the purpose that treat tumour.
Light extraction efficiency of the invention is high, and light-out effect is good, and therapeutic efficiency is high.
Embodiment 8
In order to further study the practical function that the optical fiber in the present invention punctures needle tubing, the applicant is from the blood vessel passed through
Multiple latitudes such as type and length, crossing time, the dynamics at tip, radiation response, therapeutic efficiency and piercing precision carry out
Research.
Method: enter for liver neoplasm sampling biopsy: by Seldinger arteriopuncture technology, in irradiation image
Under guidance, at a temperature of T0 (such as 37 degrees Celsius), optical fiber is punctured into needle tubing under the booster action of vibrating motor, via femoral artery
Enter liver vessel into liver artery, then from liver artery, eventually enters into inside tumor blood vessel；It swells to joined photosensitizer
Tumor tissue is irradiated, treats.
The length of vessel passed through: 1.6 meters.
Puncture needle tubing in embodiment 2,4 and 5 is tested as experimental group 1-3.
Comparative example 1: without petaloid syringe needle is divided, drawing conehead exposed, other consistent with embodiment 2.
Comparative example 2: other consistent with embodiment 2 optical fiber head diameter and other places without drawing conehead structure.
Comparative example 3: without 4 structure of spiral sleeve, also without tooth type structures are fallen, i.e., directly conehead is drawn in succession main part 8, Qi Tajun
It is consistent with embodiment 2.
Comparative example 4: without conehead is drawn, without petaloid syringe needle is divided, the structure for puncturing needle tubing front end is what metal-coating 4 wrapped up
The structure of straight type head 1, it is other consistent with embodiment 2.
Comparative example 5: the main body tube in embodiment 2 is become into spring.
Comparative example 6: the spiral sleeve 4 in embodiment 2 is become into spring.
For being summarized as follows shown in table for the above test group.
In upper table, 1) it reaches before the tumor vascular time refers to tumor vessel, required for walking in the blood vessel
Time.2) light extraction efficiency of optical fiber refers to the head of the light actually exposed on tumour photosensitizer and optical fiber by normal illumination extremely
The percentage of light on photosensitizer.3) the effective quantity of illumination on the photosensitizer for exposing to tumour that the illumination efficiency of optical fiber refers to,
It is proportional with absorption efficiency of the photosensitizer to light；4) it when tip dynamics refers to being pierced into tumor vessel inner wall when being pierced into, punctures
Power possessed by needle section.
The result of above-mentioned experimental group and contrast groups is described as follows shown:
Experimental group 1: the light loss rate on optical fiber head is less, and light emission rate is higher, can expose in tumour as required substantially,
I.e. on photosensitizer.But since dispersion angle that it goes out light is uncertain, cause the cover of light emphasis to effect somewhere slightly
It is micro- to be inferior to experimental group 2 and 3.
Experimental group 2: intravascular walking is easy, and light emission rate, the illumination efficiency of optical fiber, puncture effect and therapeutic effect etc. are equal
It is relatively good.
Experimental group 3: intravascular walking is easy, and light emission rate, the illumination efficiency of optical fiber, puncture effect and therapeutic effect etc. are equal
It is relatively good.
Comparative example 1: it due to drawing conehead exposed, with certain brittleness, therefore needs carefully, to influence to walk when walking.Due to
Draw conehead exposed, in transmission process, intravascular environment, which has it, to be had a certain impact, and in the process of walking, thereon
It is easy to attach influence light refractive index and light emission rate substance, therefore cause its optical fiber of destination locations light extraction efficiency compared with
It is low.Since its light extraction efficiency is lower, therefore the illumination efficiency of its optical fiber is leveraged, that is, exposes to effective light drop on photosensitizer
It is low.Its tip dynamics when piercing through is substantially reduced.
Comparative example 2: due to without draw conehead, then the specific aim for making it go out light is not strong so that some light can not effectively according to
It is mapped on photosensitizer, and there may be the few places of light requirement to irradiate more light instead, and needs the place of emphasis illumination
Exposure is less instead, therefore its irradiation blindness is larger, and the illumination efficiency of optical fiber is low, leverages its therapeutic efficiency.
Comparative example 3: without dentalation, then under the action of vibrating motor, its whole forward speed can be largely effected on.
Light is only from drawing conehead to project, then the universal face of its irradiation is small, is only capable of exposing to certain key regions, for other auxiliary places
Almost no light then leverages its whole illumination efficiency, to leverage its therapeutic efficiency.
Comparative example 4: it will affect its walking in the process of walking due to that can not puncture, because some are needed across blood
The place that tube wall is walked in another blood vessel is needed to be cooperated using other way, therefore largely effects on its total time walked.
Whole light extraction efficiency is lower.And light only goes out light from the joint-cutting of optical fiber top face and spiral sleeve, leads to its quantity of illumination
It substantially reduces, as comparative example 2, equally exists more blindness, prevent the light issued is from being utilized effectively,
Therefore the illumination efficiency of optical fiber is low, leverages its therapeutic efficiency.It cannot achieve puncture due to no cutting-edge structure.
Comparative example 5: the bad control of spring and direction, therefore leverage the total time walked.Since dynamics is bad
Control, therefore the puncture effect dynamics of certain point is substantially reduced.
Comparative example 6: if selection intensity and the consistent spring of the intensity of spiral sleeve, flexibility, elasticity etc. and this hair
Bright spiral sleeve is had any different, and the bad control in its direction, and the dynamics for causing its whole tip to show is less than experimental group.And
And when the spring and vibrating motor cooperation, curvature, deformation effects etc. are different from the present invention, therefore its entirety is in vibrating motor
Forward speed under effect is also much not as good as the embodiment of the present invention or experimental group.
Embodiment 9
Tumor rat model is established, the rat for taking tumor size almost the same only adds photosensitive as experimental subjects, control group
Agent is treated, and experimental group adds photosensitizer and carries out illumination using method of the present invention.
Experimental group is that puncture needle tubing as described in example 4 is irradiated laser.
Contrast groups 1-3 is the contrast groups 1-3 in embodiment 8, and laser irradiating method is consistent with experimental group.
Method: after treatment 10 days, dissecting rat, and do coronal incision by the surface seeding point of puncture of rat, by vertical and
Horizontal direction measures tumor size, gross tumor volume=a2Π/6 b (a is the minor axis of tumour, and b is the major diameter of tumour).Tumour growth
Inhibiting rate=[(control group tumor average volume-experimental group tumor average volume/control group tumor average volume) × 100%
To indicate.Then the inhibiting rate of resulting tumour growth is as shown in the table.
| Experimental group | Contrast groups 1 | Contrast groups 2 | Contrast groups 3 | |
| The inhibiting rate of tumour growth | 86.34% | 65.82% | 61.47% | 52.98% |
Therefore, in photodynamic tumor-treatment, the efficiency of light extraction efficiency and illumination has final therapeutic effect straight
Connect influence.The therapeutic effect of experimental group of the invention is apparently higher than the effect in contrast groups.
In the present invention, memory metal includes but is not limited to Nitinol, corronil, albronze, ormolu etc..
The above description is only a preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For, the invention can have various changes and changes.All any modifications made within the spirit and principles of the present invention are equal
Replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of memory metal optical fiber punctures needle tubing comprising optical fiber, it is characterised in that: the optical fiber includes main part and head
Portion, the head include straight type head and bore the drawing conehead that the diameter that technique is formed is tapered using drawing；Outside the main part
It encloses and is enclosed with main body tube, the straight type head is wrapped with metal-coating, and the periphery for drawing conehead is enclosed with by memory metal structure
At divide petaloid syringe needle, the metal-coating is fixedly connected with a point petaloid syringe needle, described to divide petaloid syringe needle by multiple conical lobe structures
At；
When temperature is T0, each conical lobe closure in point petaloid syringe needle being made of memory metal, this divides valve after being closed
Shape syringe needle is in cone shape structure, and is closed this point of petaloid syringe needle later and is wrapped in outside the drawing conehead of optical fiber just；
When temperature is T1, each conical lobe in point petaloid syringe needle being made of memory metal is opened, the drawing cone of the optical fiber
Head is exposed to outside, and allow it to will be on light direct irradiation to tumour.
2. memory metal optical fiber according to claim 1 punctures needle tubing, it is characterised in that: the metal-coating is equipped with
Dentalation so that its when advancing, resistance is big when resistance small retrogressing, to effectively reduce the thrust for puncturing and needing；
The main body tube is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is to form helical form using laser cutting to cut
The helical structure of seam；The length of main body tube is 1-2m.
3. memory metal optical fiber according to claim 2 punctures needle tubing, it is characterised in that: the metal-coating tight
In the periphery of the straight type head of optical fiber so that optical fiber and metal-coating are connected as one, the metal-coating is spiral helicine metal-coating
Or its outer surface is equipped with the structure of joint-cutting, if spiral helicine metal-coating, then metal-coating is to be swashed on metal tube
Light cuts the helical structure to form helical form joint-cutting to make it have some strength while increase certain flexibility；
The conical lobe is the conical lobe that each equal curvature of point is consistent thereon, is made of arcwall face；
The shapes and sizes of all conical lobes are consistent.
4. memory metal optical fiber according to claim 3 punctures needle tubing, it is characterised in that: constitute the gold of the metal-coating
Category piece is that the thickness of front end is less than the dentalation of the thickness of rear end so that optical fiber puncture needle is more easily walked and do not allowed forward
Easily retreat；
The optical fiber puncture needle stays in external one end and is connected with the power device for being able to carry out front and back vibration so that it is shaking
While can give one forward pressure of optical fiber puncture needle.
5. memory metal optical fiber according to claim 4 punctures needle tubing, it is characterised in that: the power device is sound wave vibration
Dynamic motor, the front and back Oscillation Amplitude of the power device are 10um-500um, vibration frequency 10Hz-1000Hz；
When being emitted in optical fiber without light, the temperature of point petaloid syringe needle transmitted in vivo is T0, is divided each in petaloid syringe needle
Conical lobe closes up for needle-shaped or cone shape；When optical fiber has light outgoing, since the fuel factor of optical fiber makes by memory metal structure
At point petaloid syringe needle temperature after being illuminated by the light gradually rise as T1, then each conical lobe divided in petaloid syringe needle is opened, optical fiber
The exposed light made on optical fiber of drawing conehead directly projected from open point of petaloid syringe needle.
6. memory metal optical fiber according to claim 5 punctures needle tubing, it is characterised in that: the main part of the optical fiber applies outside
It is covered with the main body wrap for preventing the light in optical fiber from projecting from side；It is 1.45-1.55 that optical fiber, which draws the refractive index of conehead,；
The cone angle beta for drawing conehead 2 is 7-25 °.
7. memory metal optical fiber according to claim 1 punctures needle tubing, it is characterised in that: temperature T0 is 37 DEG C, temperature T1
It is 50 DEG C；Be made as in advance in temperature T0 time-division petaloid syringe needle it is close-shaped, temperature be T1 when, divide each taper in petaloid syringe needle
Valve is made as opening shape in advance；When puncturing, not light passing in optical fiber, dividing petaloid syringe needle temperature is T0, and closure realizes that transmission punctures；?
After being punctured to the predetermined area, in optical fiber lead to laser, optical fiber draw conehead on light radiation to memory metal on, temperature be increased to T1 with
On, divide petaloid syringe needle to open.
8. memory metal optical fiber according to claim 7 punctures needle tubing, it is characterised in that: the length on the head is 7-
10mm, wherein the length for drawing conehead is 2.5-4mm；The length of the metal-coating is 4.5-6mm；
In metal-coating, the width a of joint-cutting is 0.1-0.2mm, and the width for constituting the sheet metal of metal-coating helical structure is
0.2-1mm；In falling in dentalation for metal-coating, sheet metal front end with a thickness of 50-70 μm, sheet metal rear end with a thickness of
90-110 μm, and the thickness difference of front-end and back-end is 30-50 μm.
9. memory metal optical fiber according to claim 8 punctures needle tubing, it is characterised in that: described point of petaloid syringe needle includes tail
End and tip, the conical lobe be by tail end to tip, its width is sequentially reduced, when each conical lobe closure when, tail end it is straight
Diameter is greater than the diameter at tip；The tail end integrally connected of each conical lobe forms the annular ring of cirque structure, the annular ring with
Metal-coating is fixedly connected；
When each conical lobe closure, the close closing in close to each other two side in two neighboring conical lobe, this divides petaloid
Syringe needle constitutes totally enclosed cone shape structure.
10. memory metal optical fiber according to claim 9 punctures needle tubing, it is characterised in that: in the conical lobe, be used for
It is inclined-plane with the closing of adjacent conical valve or the side separated, and the inclined-plane in all conical lobes is by direction clockwise or counterclockwise
It is consistent；
In the main body tube, with a thickness of 0.05-0.1mm, the width for constituting the joint-cutting of helical structure is 0.02-0.2mm, is constituted
The width d of the flight of helical structure is 0.5-3mm；
The main body tube is one of stainless steel, synthetic fibers, titanium alloy, Jin Heyin；
The main body tube is externally provided with overcoat polymer to increase the leakproofness of main body tube and reduce resistance；The overcoat polymer
Outside is coated with hydrophilic coating or hydrophobic coating.
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| WO2008096561A1 (en) * | 2007-02-08 | 2008-08-14 | Fujikura Ltd. | Optical fiber, optical fiber device, and bundle fiber |
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| JP2000354626A (en) * | 1999-06-15 | 2000-12-26 | Shingo Takezawa | Medical puncture needle and medical puncture needle unit |
| JP2009066104A (en) * | 2007-09-12 | 2009-04-02 | Toppan Printing Co Ltd | Microneedle structure and microneedle structure device |
| CN202843727U (en) * | 2012-02-15 | 2013-04-03 | 浙江海洋学院 | Angle variable tine bifurcating needle core |
| CN203208058U (en) * | 2013-03-01 | 2013-09-25 | 杨西群 | Nickel-titanium memory alloy needle cannula for surgery |
| US20140277039A1 (en) * | 2013-03-15 | 2014-09-18 | Acclarent, Inc. | Apparatus and method for treatment of ethmoid sinusitis |
| CN106963992B (en) * | 2017-03-22 | 2019-02-22 | 尚华 | A kind of marmem hypotube and its application in blood vessel optical fiber seal wire |
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| WO2021083465A1 (en) * | 2019-11-01 | 2021-05-06 | Richard Wolf Gmbh | Light applicator |
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