CN109602844A - 一种治疗近视和弱视的中药眼药膏及其制备方法 - Google Patents
一种治疗近视和弱视的中药眼药膏及其制备方法 Download PDFInfo
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Abstract
本发明公开一种治疗近视和弱视的中药眼药膏及其制备方法,属于中药制剂技术领域。所述治疗近视和弱视的中药眼药膏,由如下重量份数的原料制成:女贞子90‑120份、桑葚子80‑100份、菟丝子70‑110份、麦门冬60‑100份、密蒙花100‑200份、凌霄花60‑100份、红花50‑80份、茯神50‑80份、青葙子100‑150份、决明子80‑120份和凡士林600‑1000份。本发明还公开了上述治疗近视和弱视眼药膏的制备方法。本发明的治疗近视和弱视的中药眼药膏可以补肝,补肾,滋胃补脾,活血通络,补血明目,消障除翳,从而对近视、弱视、老花眼、视物不清、迎风流泪等眼部疾病有治疗效果。
Description
技术领域
本发明涉及一种治疗近视和弱视的中药眼药膏及其制备方法,属于中药制剂技术领域。
背景技术
近视、弱视和眼疾是青少年时期最常见的疾病,该病发病率高,占青少年总比例的2-3%。由于青少年时期是视觉的发育关键时期,青少年时期发生的这些眼病对青少年视力发育危害极大,许多眼部疾病如果不能在青少年时期治愈,将造成眼睛的终生残疾。
近视是一种病因多、类型多且难以治愈的眼病之一,近年来其发病率有逐年上升的趋势,尤其是青少年发病率更为明显,而目前在治疗方法上尚无较好的药物,多数采用佩戴眼镜、保健仪治疗,在严重的情况下采用手术治疗,目前市场上销售的眼保仪、近视理疗镜等保健仪器,虽然有些效果,但不能治愈,而且易复发及加重病情,也有的药物如近视明,不仅价格高,而且药放在眼部按摩,使用麻烦,药效不到位,治疗时间长,手术治疗后遗症较多,激光治疗视力不稳定。且手术激光禁忌较多,年龄要求在18岁以后。
弱视和眼疾,裸视力与矫正视力都达不到1.0者即为弱视和眼疾。弱视和眼疾多发生于儿童时期,中国4亿儿童中大约有1000多万弱视和眼疾患者,4~8岁的儿童为最佳康复期,超过12岁康复机会较渺茫。目前常用的康复方法有遮盖法、穿珠子、穿针、描图、戴眼镜、磁疗振动等,虽有一定的康复效果,但由于都是物理疗法,病灶没有直接给药,所以不能从根本上康复弱视和眼疾。
综上,亟需开发一种新的治疗近视和弱视的中药眼药膏及其制备方法,来弥补上述缺陷。
发明内容
本发明的目的之一,是提供一种治疗近视和弱视的中药眼药膏。本发明的治疗近视和弱视的中药眼药膏,为纯中药眼膏,不含任何防腐剂,主要用于治疗近视、弱视等眼部疾病,效果好、费用低、疗程短。
本发明解决上述技术问题的技术方案如下:一种治疗近视和弱视的中药眼药膏,由如下重量份数的原料制成:女贞子90-120份、桑葚子80-100份、菟丝子70-110份、麦门冬60-100份、密蒙花100-200份、凌霄花60-100份、红花50-80份、茯神50-80份、青葙子100-150份、决明子80-120份和凡士林600-1000份。
本发明选取的原料的功效:
女贞子:味苦、甘,性平,归肝、肾经,有补腰膝、壮筋骨、强阴肾之功效,主治眩晕耳鸣、腰膝酸软、须发早白、目暗不明等病症。
桑葚子:味甘、酸,性寒,归肝、肾、心经,有生津润燥、滋阴补血之功效,主治肝肾不足和血虚精亏的头晕目眩、腰酸耳鸣、须发早白、失眠多梦、津伤口渴、肠燥便秘等病症。
菟丝子:味甘,性温,归肝、肾经,有滋补肝肾、固精缩尿、安胎、明目、止泻之功效,主治阳痿遗精、尿有余沥、遗尿尿频、腰膝酸软、目昏耳鸣、肾虚胎漏、胎动不安、脾肾虚泻等病症。
麦门冬:味甘、微苦,性微寒,归肺、胃、心经,有滋阴润肺、益胃生津、清心除烦之功效,主治肺燥干咳、肺痈、阴虚劳嗽、津伤口渴、消渴、心烦失眠、咽喉疼痛、肠燥便秘、血热吐衄等病症。
密蒙花,味甘,性微寒,归肝经,有祛风、凉血、润肝、明目之功效,主治目赤肿痛、多泪羞明、青盲翳障、风弦烂眼等病症。
凌霄花,味甘,性酸,归肝、心包经,有活血化瘀、凉血祛风之功效,主治月经不调、经闭癓瘕、产后乳肿、皮肤瘙痒、痤疮等病症。
红花,味温,性辛,归心、肝经,有活血通经、散瘀止痛之功效,主治经闭、痛经、恶露不行、胸痹心痛、瘀滞腹痛、胸胁刺痛、跌打损伤、疮疡肿痛等病症。
茯神,味甘、淡,性平,归心、脾经,有宁心、安神、利水之功效,主治心虚惊悸、健忘、失眠、惊痫、小便不利等病症。
青葙子,味苦,性微寒,有清肝、明目、退翳之功效,主治肝热目赤、眼生翳膜、视物昏花、肝火眩晕等病症。
决明子,味甘、咸、苦,性微寒,归肝、肾、大肠经,有清热明目、润肠通便之功效,主治目赤涩痛、羞明多泪、头痛眩晕、目暗不明、大便秘结等病症。
中药方解:
本发明的药物原料配方中,青葙子、密蒙花具有清热养肝、泻火、明目退翳的功效,共为君药;女贞子、决明子、决明子具有益肝补肾、清热明目、利水通便的功效,是为臣药;桑葚子、红花、凌霄花具有祛瘀通络、活血行气、消肿止痛、行血去瘀、凉血祛风的功效,是为佐药;茯神、菟丝子、麦门冬具有宁心、安神、利水、心虚惊悸、健忘、失眠、惊痫、养阴生津、润肺清心的功效,是为使药。本发明的药材原料按中医理论的君、臣、佐、使的配伍原则,进行科学组方,使本发明中药药膏达到有效治疗青少儿弱视、散光、斜视、近视、视疲劳及屈光不正的目的。
中医认为窍开於肝门,属于肾脏,心肾不和,则血气停留不散,胆损肝虚,定然眼中受病。治疗眼疾,须益肝补肾,明目退翳。肝是肾之苗,肾是肝之本。补肝则神魂安静,补肾则精魄安和。精魄安和眼目自然明亮。肝肾虚损,血络瘀滞,心火过旺是导致眼部疾病的主要原因。故治疗上采用益肝补肾,补血活血,宁心、安神的方法。
以上药物经过配伍协同作用后可以补肝,补肾,滋胃补脾,活血通络,补血明目,消障除翳,从而对近视、弱视、老花眼、视物不清、迎风流泪等眼部疾病有治疗效果。采用本发明的药方不仅可扩张血管,增加眼血流量,改善微循环,解除平滑肌痉挛,同时具有极强穿透力,通过协调角膜、晶体和眼轴三者之间的关系,来达到改善视力的目的。
本发明的治疗近视和弱视的中药眼药膏的用法与疗程如下:
闭目,将眼膏外涂眼外周围,按摩睛明穴、瞳子髎、球后、四白、攒竹、鱼腰、丝竹空、印堂、医风、百会穴。按摩后做眼部保健操,远看绿色植物10分钟。每次用量2g-3g,30天为一个疗程,一般患者一个疗程即可显效,二至三个疗程方可治愈。用药间隔时间没有特别限制,患者可根据自身情况酌情选择用药次数,通常每隔三天使用一次,也可每天使用一次。
在上述技术方案的基础上,本发明还可以做如下改进。
进一步,由如下重量份数的原料制成:女贞子90份、桑葚子90份、菟丝子70份、麦门冬80份、密蒙花180份、凌霄花100份、红花50份、茯神80份、青葙子120份、决明子90份和凡士林700份。
进一步,由如下重量份数的原料制成:女贞子85份、桑葚子100份、菟丝子90份、麦门冬95份、密蒙花160份、凌霄花80份、红花65份、茯神65份、青葙子125份、决明子85份和凡士林800份。
进一步,由如下重量份数的原料制成:女贞子100份、桑葚子80份、菟丝子110份、麦门冬80份、密蒙花150份、凌霄花60份、红花80份、茯神50份、青葙子150份、决明子90份和凡士林1000份。
本发明的目的之二,是提供上述治疗近视和弱视的中药眼药膏的制备方法。本发明的治疗近视和弱视的中药眼药膏制备方法简单,成本低廉,市场前景广阔,适合规模化生产。
本发明解决上述技术问题的技术方案如下:一种治疗近视和弱视的中药眼药膏的制备方法,包括如下步骤:
步骤1:取如下重量份数的原料:女贞子90-120份、桑葚子80-100份、菟丝子70-110份、麦门冬60-100份、密蒙花100-200份、凌霄花60-100份、红花50-80份、茯神50-80份、青葙子100-150份、决明子80-120份和凡士林600-1000份。,取女贞子、桑葚子、菟丝子、麦门冬、密蒙花、凌霄花、红花、茯神、青葙子和决明子,加入上述药材5-8重量倍的水,浸泡2小时后,先煎煮1小时,待药液稍微冷却后,再煎煮45分钟,在煎煮的同时收集药液挥发油,得到蒸馏液;
步骤2:将步骤1蒸煮后的药液过滤,得到滤液;
步骤3:将步骤2得到的滤液浓缩,得到浸膏;
步骤4:将步骤3得到的浸膏密封,在30℃-35℃的温度下自然发酵24小时,得到发酵后的浸膏;
步骤5:将凡士林加热至80℃熔化后,降温至35℃-40℃,与步骤4得到的发酵后的浸膏混合搅拌混合均匀,得到半成品;
步骤6:将步骤1得到的蒸馏液加入到步骤5得到的半成品中,搅拌混合均匀,然后灌装、灭菌后,即得到所述治疗近视和弱视的中药眼药膏。
在上述技术方案的基础上,本发明还可以做如下改进。
进一步,步骤3中,所述浸膏在65℃-70℃相对密度为1.01。
进一步,步骤6中,所述灭菌采用钴60射线,剂量为8KGY-12KGY。
本发明的有益效果:
(1)本发明的治疗近视和弱视的中药眼药膏,可以补肝,补肾,滋胃补脾,活血通络,补血明目,消障除翳,从而对近视、弱视、老花眼、视物不清、迎风流泪等眼部疾病有治疗效果。采用本发明的中药眼药膏不仅可扩张血管,增加眼血流量,改善微循环,解除平滑肌痉挛,同时具有极强穿透力,通过协调角膜、晶体和眼轴三者之间的关系,来达到改善视力的目的。
(2)本发明的治疗近视和弱视的中药眼药膏制备方法简单,成本低廉,市场前景广阔,适合规模化生产。
具体实施方式
以下结合具体实施例对本发明的原理和特征进行描述,所举实例只用于解释本发明,并非用于限定本发明的范围。
实施例1
本实施例的治疗近视和弱视的中药眼药膏,由如下重量的原料制成:女贞子90kg、桑葚子90kg、菟丝子70kg、麦门冬80kg、密蒙花180kg、凌霄花100kg、红花50kg、茯神80kg、青葙子120kg、决明子90kg和凡士林700kg。
上述治疗近视和弱视的中药眼药膏的制备方法,包括如下步骤:
步骤1:取如下重量的原料:女贞子90kg、桑葚子90kg、菟丝子70kg、麦门冬80kg、密蒙花180kg、凌霄花100kg、红花50kg、茯神80kg、青葙子120kg、决明子90kg和凡士林700kg,取女贞子、桑葚子、菟丝子、麦门冬、密蒙花、凌霄花、红花、茯神、青葙子和决明子,加入上述药材5重量倍的水,浸泡2小时后,先煎煮1小时,待药液稍微冷却后,再煎煮45分钟,在煎煮的同时收集药液挥发油,得到蒸馏液;
步骤2:将步骤1蒸煮后的药液过滤,得到滤液;
步骤3:将步骤2得到的滤液浓缩,得到浸膏;所述浸膏在65℃相对密度为1.01;
步骤4:将步骤3得到的浸膏密封,在35℃的温度下自然发酵24小时,得到发酵后的浸膏;
步骤5:将凡士林加热至80℃熔化后,降温至40℃,与步骤4得到的发酵后的浸膏混合搅拌混合均匀,得到半成品;
步骤6:将步骤1得到的蒸馏液加入到步骤5得到的半成品中,搅拌混合均匀,然后灌装,采用剂量为8KGY的钴60射线灭菌后,即得到所述治疗近视和弱视的中药眼药膏。
实施例2
本实施例的治疗近视和弱视的中药眼药膏,由如下重量的原料制成:女贞子85kg、桑葚子100kg、菟丝子90kg、麦门冬95kg、密蒙花160kg、凌霄花80kg、红花65kg、茯神65kg、青葙子125kg、决明子85kg和凡士林800kg。
上述治疗近视和弱视的中药眼药膏的制备方法,包括如下步骤:
步骤1:取如下重量的原料:女贞子85kg、桑葚子100kg、菟丝子90kg、麦门冬95kg、密蒙花160kg、凌霄花80kg、红花65kg、茯神65kg、青葙子125kg、决明子85kg和凡士林800kg,取女贞子、桑葚子、菟丝子、麦门冬、密蒙花、凌霄花、红花、茯神、青葙子和决明子,加入上述药材6重量倍的水,浸泡2小时后,先煎煮1小时,待药液稍微冷却后,再煎煮45分钟,在煎煮的同时收集药液挥发油,得到蒸馏液;
步骤2:将步骤1蒸煮后的药液过滤,得到滤液;
步骤3:将步骤2得到的滤液浓缩,得到浸膏;所述浸膏在68℃相对密度为1.01;
步骤4:将步骤3得到的浸膏密封,在33℃的温度下自然发酵24小时,得到发酵后的浸膏;
步骤5:将凡士林加热至80℃熔化后,降温38℃,与步骤4得到的发酵后的浸膏混合搅拌混合均匀,得到半成品;
步骤6:将步骤1得到的蒸馏液加入到步骤5得到的半成品中,搅拌混合均匀,然后灌装,采用剂量为10KGY的钴60射线灭菌后,即得到所述治疗近视和弱视的中药眼药膏。
女贞子100份、桑葚子80份、菟丝子110份、麦门冬80份、密蒙花150份、凌霄花60份、红花80份、茯神50份、青葙子150份、决明子90份和凡士林1000份。
实施例3
本实施例的治疗近视和弱视的中药眼药膏,由如下重量的原料制成:女贞子100kg、桑葚子80kg、菟丝子110kg、麦门冬80kg、密蒙花150kg、凌霄花60kg、红花80kg、茯神50kg、青葙子150kg、决明子90kg和凡士林1000kg。
上述治疗近视和弱视的中药眼药膏的制备方法,包括如下步骤:
步骤1:取如下重量的原料:女贞子100kg、桑葚子80kg、菟丝子110kg、麦门冬80kg、密蒙花150kg、凌霄花60kg、红花80kg、茯神50kg、青葙子150kg、决明子90kg和凡士林1000kg,取女贞子、桑葚子、菟丝子、麦门冬、密蒙花、凌霄花、红花、茯神、青葙子和决明子,加入上述药材5-8重量倍的水,浸泡2小时后,先煎煮1小时,待药液稍微冷却后,再煎煮45分钟,在煎煮的同时收集药液挥发油,得到蒸馏液;
步骤2:将步骤1蒸煮后的药液过滤,得到滤液;
步骤3:将步骤2得到的滤液浓缩,得到浸膏;所述浸膏在70℃相对密度为1.01;
步骤4:将步骤3得到的浸膏密封,在33℃的温度下自然发酵24小时,得到发酵后的浸膏;
步骤5:将凡士林加热至80℃熔化后,降温至40℃,与步骤4得到的发酵后的浸膏混合搅拌混合均匀,得到半成品;
步骤6:将步骤1得到的蒸馏液加入到步骤5得到的半成品中,搅拌混合均匀,然后灌装,采用剂量为12KGY的钴60射线灭菌后,即得到所述治疗近视和弱视的中药眼药膏。
临床例1
胡某,8岁,男性,河南省郑州市郑东新区聚源路小学学生。近视,原裸视力0.6以上。采用本发明实施例1得到的治疗近视和弱视的中药眼药膏,每次用量2g-3g,每天使用一次,一个疗程后,裸视力达到1.2。二个疗程后,裸视力达到1.5,痊愈。
临床例2
武某,22岁,女性,河南省新乡市红太阳幼儿园老师。弱视,原裸视力0.4以上。采用本发明实施例2得到的治疗近视和弱视的中药眼药膏,每次用量2g-3g,每天使用一次,两个疗程后,裸视力达到1.2。三个疗程后,裸视力达到1.5,痊愈。
临床例3
刘某,14岁,女性,河南省郑州市86中学生。散光、斜视。采用本发明实施例2得到的治疗近视和弱视的中药眼药膏,每次用量2g-3g,每隔三天使用一次,两个疗程后,裸视力达到1.0。三个疗程后,裸视力达到1.5,痊愈。
临床例4
张某,16岁,男性,河南省管城区回民中学学生。近视,原裸视力0.6以上。采用本发明实施例3得到的治疗近视和弱视的中药眼药膏,每次用量2g-3g,每隔三天使用一次,三个疗程后,裸视力达到1.5,痊愈。
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (7)
1.一种治疗近视和弱视的中药眼药膏,其特征在于,由如下重量份数的原料制成:女贞子90-120份、桑葚子80-100份、菟丝子70-110份、麦门冬60-100份、密蒙花100-200份、凌霄花60-100份、红花50-80份、茯神50-80份、青葙子100-150份、决明子80-120份和凡士林600-1000份。
2.根据权利要求1所述的治疗近视和弱视的中药眼药膏,其特征在于,由如下重量份数的原料制成:女贞子90份、桑葚子90份、菟丝子70份、麦门冬80份、密蒙花180份、凌霄花100份、红花50份、茯神80份、青葙子120份、决明子90份和凡士林700份。
3.根据权利要求1所述的治疗近视和弱视的中药眼药膏,其特征在于,由如下重量份数的原料制成:女贞子85份、桑葚子100份、菟丝子90份、麦门冬95份、密蒙花160份、凌霄花80份、红花65份、茯神65份、青葙子125份、决明子85份和凡士林800份。
4.根据权利要求1所述的治疗近视和弱视的中药眼药膏,其特征在于,由如下重量份数的原料制成:女贞子100份、桑葚子80份、菟丝子110份、麦门冬80份、密蒙花150份、凌霄花60份、红花80份、茯神50份、青葙子150份、决明子90份和凡士林1000份。
5.一种治疗近视和弱视的中药眼药膏的制备方法,其特征在于,包括如下步骤:
步骤1:取如下重量份数的原料:女贞子80份、桑葚子100份、菟丝子90份、麦门冬100份、密蒙花180份、凌霄花80份、红花65份、茯神65份、青葙子125份、决明子85份,取女贞子、桑葚子、菟丝子、麦门冬、密蒙花、凌霄花、红花、茯神、青葙子和决明子,加入上述药材5-8重量倍的水,浸泡2小时后,先煎煮1小时,待药液稍微冷却后,再煎煮45分钟,在煎煮的同时收集药液挥发油,得到蒸馏液;
步骤2:将步骤1蒸煮后的药液过滤,得到滤液;
步骤3:将步骤2得到的滤液浓缩,得到浸膏;
步骤4:将步骤3得到的浸膏密封,在30℃-35℃的温度下自然发酵24小时,得到发酵后的浸膏;
步骤5:将凡士林加热至80℃熔化后,降温至35℃-40℃,与步骤4得到的发酵后的浸膏混合搅拌混合均匀,得到半成品;
步骤6:将步骤1得到的蒸馏液加入到步骤5得到的半成品中,搅拌混合均匀,然后灌装、灭菌后,即得到所述治疗近视和弱视的中药眼药膏。
6.根据权利要求5所述的治疗近视和弱视的中药眼药膏的制备方法,其特征在于,步骤3中,所述浸膏在65℃-70℃相对密度为1.01。
7.根据权利要求5所述的治疗近视和弱视的中药眼药膏的制备方法,其特征在于,步骤6中,所述灭菌采用钴60射线,剂量为8KGY-12KGY。
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