CN109589399A - A kind of ageratum-liquid and preparation method thereof for treating tinea pedis - Google Patents

A kind of ageratum-liquid and preparation method thereof for treating tinea pedis Download PDF

Info

Publication number
CN109589399A
CN109589399A CN201910109698.3A CN201910109698A CN109589399A CN 109589399 A CN109589399 A CN 109589399A CN 201910109698 A CN201910109698 A CN 201910109698A CN 109589399 A CN109589399 A CN 109589399A
Authority
CN
China
Prior art keywords
parts
tinea pedis
ageratum
liquid
mixed liquor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910109698.3A
Other languages
Chinese (zh)
Inventor
周治国
曲来志
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wuhan Taifu Pharmaceutical Co Ltd
Original Assignee
Wuhan Taifu Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wuhan Taifu Pharmaceutical Co Ltd filed Critical Wuhan Taifu Pharmaceutical Co Ltd
Priority to CN201910109698.3A priority Critical patent/CN109589399A/en
Publication of CN109589399A publication Critical patent/CN109589399A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

The invention proposes a kind of ageratum-liquids and preparation method thereof for treating tinea pedis, with a kind of ageratum-liquid for treating tinea pedis prepared by the present invention, compared to traditional medicament, added with peppermint, ginger, the medicinal materials such as balsamine, makes product free from extraneous odour, action temperature and, easily absorb and it is small to human body irritation；A kind of ageratum-liquid for treating tinea pedis prepared by the present invention, directly acquires the extracting solution of each medicinal material, enhances the antibacterial action of product, and does not allow easy to recur after curing, and can fundamentally treat tinea pedis；Various raw materials of the invention are prepared by reasonable, while giving full play to the distinctive performance of each raw material itself and effect, have also taken into account mutual complementation, drug effect complements each other.

Description

A kind of ageratum-liquid and preparation method thereof for treating tinea pedis
Technical field
The present invention relates to drug preparation technical field more particularly to a kind of ageratum-liquid for treating tinea pedis and its preparation sides Method.
Background technique
Tinea pedis, also referred to as tinea pedis are the foot dermatosis as caused by pathogenic fungus, have infectiousness, tinea pedis is in the whole world Popular, more universal in subtropical and tropical zones, in China, the disease incidence of tinea pedis is also quite high.The vola of people and toe Between without sebaceous glands, thus lack inhibit skin filamentous fungi fatty acid, physiological defense mechanism is poor, and the skin at these positions Skin sweat gland is but very abundant, perspires relatively more, then due to sole since air circulation is poor, and perspiration leads to the moist temperature in part It is warm, be conducive to the growth of filamentous fungi, in addition, bottom of the foot keratoderma is thicker, the keratin in cuticula is in fungi Nutriment, be conducive to the growth of fungi.
Women during gestation, due to endocrine variation, can also cause skin to decline to antimycotic ability, be easy to suffer from Tinea pedis；Overweight people is because moist between toe, and sweat dipping is also easy to suffer from tinea pedis, and pedal skin is destroyed skin defense function by wound, It is also one of the factor for inducing tinea pedis；Diabetic leads to metabolism disorder due to lacking insulin, and skin sugar content increases Adding causes resistivity to decline, and is also easy to cause the generation of tinea pedis；Corticosteroid hormone is used for a long time in abuse of antibiotics With immunosuppressor etc., so that skin normal flora is lacked of proper care, also will increase the infectibility of tinea pedis.
It is wet soft that clinical manifestation plays blister, decortication or skin whitening between toe, can also occur rotten to the corn or pachyderma, Coarse, cracking, and vola pedis and edge can be spread to, and itch along with huge, it can be with local suppuration, red and swollen, pain and abdomen stock Ditch enlargement of lymph nodes, or even form the secondary infections such as shank erysipelas and cellulitis.Due to being scratched place with hand, often infect extremely Hand, thus the tinea manuum is also easily caused, fungi grows on nail, is easy to cause onychomycosis, brings and feels embarrassed to mention to people's lives Worry, the harm of tinea pedis can not be ignored, and when morbidity not only influences daily life, but also influences personal image, and may cause after Hair sexuality dye, infects and arrives other positions of body, brings huge pain and worry to patient.
The method for being traditionally used for treatment tinea pedis is so that drug is passed through Cutaneous permeation by the way that drug is directly applied to affected part outside It is treated, common are on the market various for treating the infection of the anti-dermatophytes such as tinea pedis into the tissue of human body Drug, there are also for treating tinea pedis shoes, insole, socks etc., these methods can not kill corium due to its antimicrobial component deficiency The defects of layer germ infection, and there are the courses for the treatment of long, weak curative effect, illness high recurrence rate, clinical effectiveness is not especially desirable；And Some products have certain irritation to skin and volatilize the smell of not smelling good；Although treating beri-beri medicine currently on the market Object is varied, emerges one after another, and still, Western medicine has toxic side effect more, and palliative, for controlling for intractable beriberi Treatment is easily recurred.And though Chinese materia medica preparation in the market can control that it is basic, and some traditional Chinese medicine ingredients itself have biggish poison Property, the efficacy of a drug is excessively powerful, damages other functions of patient body.
Summary of the invention
It is low in cost and make in view of this, without side-effects, drug effect is powerful, and curative effect is obvious the invention proposes no rebound A kind of ageratum-liquid and preparation method thereof for treating tinea pedis of standby simple flow.
The technical scheme of the present invention is realized as follows:
On the one hand, the present invention provides a kind of ageratum-liquid for treating tinea pedis, the components including following mass fraction: the leaves of pulse plants 40-100 parts fragrant, 30-50 parts of purple perilla, 30-50 parts of rhizoma atractylodis, 10-20 parts of hickory nut, 10-30 parts of frutus cnidii, 10-15 parts of the fruit of summer cypress, 5-10 parts of alumen, 3-10 parts of peppermint, 5-15 parts of Cortex Phellodendri, brave 3-10 parts of nurse root, 3-10 parts of balsamine, 5-10 parts of Golden Larch Bark, radix paeoniae rubra 1-10 parts, 3-9 parts of Chinese prickly ash, 5-10 parts of ginger.
On the basis of above technical scheme, it is preferred that the component including following mass fraction: 50-60 parts of wrinkled giant hyssop, purple perilla 35-45 parts, 35-45 parts of rhizoma atractylodis, 15-18 parts of hickory nut, 15-25 parts of frutus cnidii, 11-13 parts of the fruit of summer cypress, 6-8 parts of alumen, peppermint 5-8 parts, 6-12 parts of Cortex Phellodendri, brave 6-8 parts of nurse root, 6-8 parts of balsamine, 6-8 parts of Golden Larch Bark, 3-8 parts of radix paeoniae rubra, 5-8 parts of Chinese prickly ash, ginger 6-8 parts.
On the other hand, the present invention provides a kind of preparation methods of ageratum-liquid for treating tinea pedis, comprising the following steps:
S1, it is celestial with wrinkled giant hyssop, purple perilla, rhizoma atractylodis, hickory nut, frutus cnidii, the fruit of summer cypress, alumen, peppermint, Cortex Phellodendri, brave nurse root, phoenix Flower, Golden Larch Bark, radix paeoniae rubra, Chinese prickly ash, ginger are raw material；
S2 cleans the step S1 raw material chosen, and crushes, and lard is added and stir-fries, obtains mixture；
S3, the mixture that step S2 is obtained impregnate 30-60d with ethyl alcohol, obtain mixed liquor 1；
S4 filters the mixed liquor 1 that step S3 is obtained, and obtains filtrate, and salt, light-coloured vinegar is added, and stirring obtains mixed liquor 2；
S5, by the filling filtering of mixed liquor 2, sterilizing.
On the basis of above technical scheme, it is preferred that in the step S1, with 55 parts of wrinkled giant hyssop, 40 parts of purple perilla, rhizoma atractylodis 40 Part, 16 parts of hickory nut, 22 parts of frutus cnidii, 12 parts of the fruit of summer cypress, 7 parts of alumen, 7 parts of peppermint, 10 parts of Cortex Phellodendri, brave 7 parts of nurse root, balsamine 7 parts, 7 parts of Golden Larch Bark, 5 parts of radix paeoniae rubra, 6 parts of Chinese prickly ash, 7 parts of ginger be raw material.
On the basis of above technical scheme, it is preferred that in the step S2, raw material quality hundred that step S1 is chosen Divide the physiology salt that concentration is 0.5-1% to wash 3-5 times, be crushed to 40-50 sieve, lard stir-frying 30-45min is added.
On the basis of above technical scheme, it is preferred that in the step S3, mixture quality that step S2 is obtained The mass ratio of the ethyl alcohol immersion 35-45d that percentage concentration is 45-60%, mixture and ethyl alcohol is 1:(3-5), obtain mixed liquor 1.
On the basis of above technical scheme, it is preferred that in the step S3, mixture concentration that step S2 is obtained For 55% ethyl alcohol immersion 40d, the mass ratio of mixture and ethyl alcohol is 1:4, obtains mixed liquor 1.
On the basis of above technical scheme, it is preferred that in the step S4,1 vacuum of mixed liquor that step S3 is obtained Filtering obtains filtrate, and the mass ratio that salt and filtrate is added is (0.05-0.1): 1, it is 4-6%'s that mass percentage concentration, which is added, The mass ratio of light-coloured vinegar, light-coloured vinegar and filtrate is (0.05-0.3): 1,50-60 DEG C of stirring 30-45min obtains mixed liquor 2.
On the basis of above technical scheme, it is preferred that in the step S4,1 vacuum of mixed liquor that step S3 is obtained Filtering obtains filtrate, and the mass ratio that salt and filtrate is added is 0.08:1, and the light-coloured vinegar that mass percentage concentration is 5%, light-coloured vinegar is added Mass ratio with filtrate is 0.1:1, and 55 DEG C of stirring 40min obtain mixed liquor 2.
On the basis of above technical scheme, it is preferred that in the step S5, the in-depth filtration film of mixed liquor 2 is filtered, It is filling, 110-130 DEG C of sterilizing 30-45min.
A kind of ageratum-liquid for treating tinea pedis of the invention and preparation method thereof has with following compared with the existing technology Beneficial effect:
(1) a kind of ageratum-liquid for treating tinea pedis prepared by the present invention is used, compared to traditional medicament, added with thin Lotus, ginger, the medicinal materials such as balsamine make product free from extraneous odour, action temperature and, easily absorb and small to human body irritation；
(2) a kind of ageratum-liquid for treating tinea pedis prepared by the present invention is used, the extracting solution of each medicinal material is directly acquired, makes The antibacterial action of product enhances, and does not allow easy to recur after curing, and can fundamentally treat tinea pedis；
(3) a kind of various raw materials of ageratum-liquid for treating tinea pedis provided by the invention are prepared by reasonable, sufficiently While playing the distinctive performance of each raw material itself and effect, mutual complementation is also taken into account, drug effect complements each other.
Specific embodiment
Below in conjunction with embodiment of the present invention, the technical solution in embodiment of the present invention is carried out clearly and completely Description, it is clear that described embodiment is only some embodiments of the invention, rather than whole embodiments.Base Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts all Other embodiments shall fall within the protection scope of the present invention.
Embodiment one
A kind of preparation method of ageratum-liquid that treating tinea pedis, comprising the following steps:
S1, with wrinkled giant hyssop 40g, purple perilla 30g, rhizoma atractylodis 30g, hickory nut 10g, frutus cnidii 10g, fruit of summer cypress 10g, alumen 5g, thin Lotus 3g, Cortex Phellodendri 5g, brave nurse root 3g, balsamine 3g, Golden Larch Bark 5g, radix paeoniae rubra 1g, Chinese prickly ash 3g, ginger 5g are raw material；
S2, the physiology salt that the raw material mass percentage concentration that step S1 is chosen is 0.5% are washed 3 times, and 40 sieves are crushed to, Lard stir-frying 30min is added, obtains mixture；
S3, the ethyl alcohol that the mixture mass percentage concentration that step S2 is obtained is 45% impregnate 35d, mixture and ethyl alcohol Mass ratio be 1:3, obtain mixed liquor 1；
S4,1 vacuum filter of mixed liquor that step S3 is obtained obtain filtrate, and the mass ratio that salt and filtrate is added is 0.05:1, is added the light-coloured vinegar that mass percentage concentration is 4%, and the mass ratio of light-coloured vinegar and filtrate is 0.05:1,50 DEG C of stirring 30min, Obtain mixed liquor 2；
S5 filters the in-depth filtration film of mixed liquor 2, filling, 110 DEG C of sterilizing 30min.
In order to more preferably illustrate the invention effect of embodiment one, 25 males are organized, 25 women suffer from the volunteer of tinea pedis, Respectively take the ageratum-liquid of 2 tanks treatment tinea pedis prepared by the present invention in the morning, afternoon and evening daily, for 2 weeks, investigation uses knot after 2 weeks Fruit, as shown in the table:
Group Number of cases Recovery from illness Effectively In vain Cure rate It is efficient
Male 25 20 3 2 80% 92%
Women 25 22 2 1 88% 96%
Embodiment two
A kind of preparation method of ageratum-liquid that treating tinea pedis, comprising the following steps:
S1, with wrinkled giant hyssop 55g, purple perilla 40g, rhizoma atractylodis 40g, hickory nut 16g, frutus cnidii 22g, fruit of summer cypress 12g, alumen 7g, thin Lotus 7g, Cortex Phellodendri 10g, brave nurse root 7g, balsamine 7g, Golden Larch Bark 7g, radix paeoniae rubra 5g, Chinese prickly ash 6g, ginger 7g are raw material；
S2, the physiology salt that the raw material mass percentage concentration that step S1 is chosen is 0.8% are washed 4 times, and 45 sieves are crushed to, Lard stir-frying 40min is added, obtains mixture；
S3, the ethyl alcohol that the mixture mass percentage concentration that step S2 is obtained is 55% impregnate 40d, mixture and ethyl alcohol Mass ratio be 1:4, obtain mixed liquor 1；
S4,1 vacuum filter of mixed liquor that step S3 is obtained obtain filtrate, and the mass ratio that salt and filtrate is added is Mass percentage concentration is added as 5% light-coloured vinegar in 0.08:1, and the mass ratio of light-coloured vinegar and filtrate is 0.1:1, and 55 DEG C of stirring 40min are obtained Mixed liquor 2；
S5 filters the in-depth filtration film of mixed liquor 2, filling, 120 DEG C of sterilizing 40min.
In order to more preferably illustrate the invention effect of embodiment two, 25 males are organized, 25 women suffer from the volunteer of tinea pedis, Respectively take the ageratum-liquid of 2 tanks treatment tinea pedis prepared by the present invention in the morning, afternoon and evening daily, for 2 weeks, investigation uses knot after 2 weeks Fruit, as shown in the table:
Group Number of cases Recovery from illness Effectively In vain Cure rate It is efficient
Male 25 22 3 0 88% 100%
Women 25 22 2 1 88% 96%
Embodiment three
A kind of preparation method of ageratum-liquid that treating tinea pedis, comprising the following steps:
S1, with wrinkled giant hyssop 100g, purple perilla 50g, rhizoma atractylodis 50g, hickory nut 20g, frutus cnidii 30g, fruit of summer cypress 15g, alumen 10g, Peppermint 10g, Cortex Phellodendri 15g, brave nurse root 10g, balsamine 10g, Golden Larch Bark 10g, radix paeoniae rubra 10g, Chinese prickly ash 9g, ginger 10g are raw material；
S2, the physiology salt that the raw material mass percentage concentration that step S1 is chosen is 1% wash 5 times, are crushed to 50 sieves, add Enter lard stir-frying 45min, obtains mixture；
S3, the ethyl alcohol that the mixture mass percentage concentration that step S2 is obtained is 60% impregnate 45d, mixture and ethyl alcohol Mass ratio be 1:5, obtain mixed liquor 1；
S4,1 vacuum filter of mixed liquor that step S3 is obtained obtain filtrate, and the mass ratio that salt and filtrate is added is Mass percentage concentration is added as 6% light-coloured vinegar in 0.1:1, and the mass ratio of light-coloured vinegar and filtrate is 0.3:1, and 60 DEG C of stirring 45min are obtained Mixed liquor 2；
S5 filters the in-depth filtration film of mixed liquor 2, filling, 130 DEG C of sterilizing 45min.
In order to more preferably illustrate the invention effect of embodiment three, 25 males are organized, 25 women suffer from the volunteer of tinea pedis, Respectively take the ageratum-liquid of 2 tanks treatment tinea pedis prepared by the present invention in the morning, afternoon and evening daily, for 2 weeks, investigation uses knot after 2 weeks Fruit, as shown in the table:
Group Number of cases Recovery from illness Effectively In vain Cure rate It is efficient
Male 25 20 4 1 80% 96%
Women 25 21 3 1 84% 96%
The foregoing is merely better embodiments of the invention, are not intended to limit the invention, all of the invention Within spirit and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of ageratum-liquid for treating tinea pedis, it is characterised in that: the component including following mass fraction: wrinkled giant hyssop 40-100 Part, 30-50 parts of purple perilla, 30-50 parts of rhizoma atractylodis, 10-20 parts of hickory nut, 10-30 parts of frutus cnidii, 10-15 parts of the fruit of summer cypress, alumen 5-10 Part, 3-10 parts of peppermint, 5-15 parts of Cortex Phellodendri, brave 3-10 parts of nurse root, 3-10 parts of balsamine, 5-10 parts of Golden Larch Bark, 1-10 parts of radix paeoniae rubra, flower 3-9 parts of green pepper, 5-10 parts of ginger.
2. a kind of ageratum-liquid for treating tinea pedis as described in claim 1, it is characterised in that: including following mass fraction Component: 50-60 parts of wrinkled giant hyssop, 35-45 parts of purple perilla, 35-45 parts of rhizoma atractylodis, 15-18 parts of hickory nut, 15-25 parts of frutus cnidii, the fruit of summer cypress 11-13 parts, it is 6-8 parts of alumen, 5-8 parts of peppermint, 6-12 parts of Cortex Phellodendri, brave 6-8 parts of nurse root, 6-8 parts of balsamine, 6-8 parts of Golden Larch Bark, red 3-8 parts of Chinese herbaceous peony, 5-8 parts of Chinese prickly ash, 6-8 parts of ginger.
3. a kind of preparation method for the ageratum-liquid for treating tinea pedis, it is characterised in that: the following steps are included:
S1, with wrinkled giant hyssop, purple perilla, rhizoma atractylodis, hickory nut, frutus cnidii, the fruit of summer cypress, alumen, peppermint, Cortex Phellodendri, brave nurse root, balsamine, soil Chaste tree skin, radix paeoniae rubra, Chinese prickly ash, ginger are raw material；
S2 cleans the step S1 raw material chosen, and crushes, and lard is added and stir-fries, obtains mixture；
S3, the mixture that step S2 is obtained impregnate 30-60d with ethyl alcohol, obtain mixed liquor 1；
S4 filters the mixed liquor 1 that step S3 is obtained, and obtains filtrate, and salt, light-coloured vinegar is added, and stirring obtains mixed liquor 2；
S5 filters mixed liquor 2, filling, sterilizing.
4. a kind of preparation method for the ageratum-liquid for treating tinea pedis as claimed in claim 3, it is characterised in that: the step In S1, with 55 parts of wrinkled giant hyssop, 40 parts of purple perilla, 40 parts of rhizoma atractylodis, 16 parts of hickory nut, 22 parts of frutus cnidii, 12 parts of the fruit of summer cypress, 7 parts of alumen, thin 7 parts of lotus, 10 parts of Cortex Phellodendri, brave 7 parts of nurse root, 7 parts of balsamine, 7 parts of Golden Larch Bark, 5 parts of radix paeoniae rubra, 6 parts of Chinese prickly ash, 7 parts of ginger be raw material.
5. a kind of preparation method for the ageratum-liquid for treating tinea pedis as claimed in claim 3, it is characterised in that: the step In S2, the raw material that step S1 chooses is washed 3-5 times with the physiology salt that mass percentage concentration is 0.5-1%, is crushed to 40-50 Lard stir-frying 30-45min is added in sieve.
6. a kind of preparation method for the ageratum-liquid for treating tinea pedis as claimed in claim 3, it is characterised in that: the step In S3, the mixture that step S2 is obtained is impregnated into 35-45d, mixture and ethyl alcohol with the ethyl alcohol that mass percentage concentration is 45-60% Mass ratio be 1:(3-5), obtain mixed liquor 1.
7. a kind of preparation method for the ageratum-liquid for treating tinea pedis as claimed in claim 6, it is characterised in that: the step In S3, the ethyl alcohol that the mixture mass percentage concentration that step S2 is obtained is 55% impregnates 40d, the quality of mixture and ethyl alcohol Than obtaining mixed liquor 1 for 1:4.
8. a kind of preparation method for the ageratum-liquid for treating tinea pedis as claimed in claim 3, it is characterised in that: the step In S4,1 vacuum filter of mixed liquor that step S3 is obtained obtains filtrate, and the mass ratio that salt and filtrate is added is (0.05- 0.1): 1, mass percentage concentration is added as the light-coloured vinegar of 4-6%, the mass ratio of light-coloured vinegar and filtrate is (0.05-0.3): 1,50-60 DEG C 30-45min is stirred, mixed liquor 2 is obtained.
9. a kind of preparation method for the ageratum-liquid for treating tinea pedis as claimed in claim 8, it is characterised in that: the step In S4,1 vacuum filter of mixed liquor that step S3 is obtained obtains filtrate, and the mass ratio that salt and filtrate is added is 0.08:1, adds Enter mass percentage concentration for 5% light-coloured vinegar, the mass ratio of light-coloured vinegar and filtrate is 0.1:1, and 55 DEG C of stirring 40min obtain mixed liquor 2.
10. a kind of preparation method for the ageratum-liquid for treating tinea pedis as claimed in claim 3, it is characterised in that: the step In rapid S5, the in-depth filtration film of mixed liquor 2 is filtered, filling, 110-130 DEG C of sterilizing 30-45min.
CN201910109698.3A 2019-01-18 2019-01-18 A kind of ageratum-liquid and preparation method thereof for treating tinea pedis Pending CN109589399A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910109698.3A CN109589399A (en) 2019-01-18 2019-01-18 A kind of ageratum-liquid and preparation method thereof for treating tinea pedis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910109698.3A CN109589399A (en) 2019-01-18 2019-01-18 A kind of ageratum-liquid and preparation method thereof for treating tinea pedis

Publications (1)

Publication Number Publication Date
CN109589399A true CN109589399A (en) 2019-04-09

Family

ID=65967203

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910109698.3A Pending CN109589399A (en) 2019-01-18 2019-01-18 A kind of ageratum-liquid and preparation method thereof for treating tinea pedis

Country Status (1)

Country Link
CN (1) CN109589399A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102988934A (en) * 2012-10-30 2013-03-27 严中明 Prescription of traditional Chinese medicine for treating beriberi and use method thereof
CN103705617A (en) * 2014-01-09 2014-04-09 修世平 Liquid medicine for treating beriberi
CN105816668A (en) * 2016-05-24 2016-08-03 孝感市奇思妙想文化传媒有限公司 Traditional Chinese medicine for treating beriberi

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102988934A (en) * 2012-10-30 2013-03-27 严中明 Prescription of traditional Chinese medicine for treating beriberi and use method thereof
CN103705617A (en) * 2014-01-09 2014-04-09 修世平 Liquid medicine for treating beriberi
CN105816668A (en) * 2016-05-24 2016-08-03 孝感市奇思妙想文化传媒有限公司 Traditional Chinese medicine for treating beriberi

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王震: "《外用妇保洗剂的制备和临床应用》", 《中国中医药科技》 *

Similar Documents

Publication Publication Date Title
CN102091203B (en) External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof
CN108310222A (en) The fine and soft hemostatic traditional Chinese medicine composition of saw, preparation method and applications
CN1879601B (en) Prescription of hair-blackening formulation and preparation method thereof
CN110368339A (en) Face mask of traditional Chinese medicine composition and preparation method thereof, application method
CN101095799A (en) Liquor preparations for removing dandruff and method for preparing the same
CN106668294A (en) Salvia miltiorrhiza leaf composite healthcare tea having efficacies for reducing blood glucose, reducing blood fat and lowering blood pressure and preparation method and use of salvia miltiorrhiza composite leaf healthcare tea
KR101913536B1 (en) Method of making Natural Hair Restorer
CN105999010A (en) Compound tea seed powder foot bath agent and preparation method thereof
CN104324310B (en) It is a kind of to be used to treat Chinese medicine composition of fungal keratitis and preparation method thereof after immunosupress
CN109589399A (en) A kind of ageratum-liquid and preparation method thereof for treating tinea pedis
CN106177192B (en) Bi-component compound medicine for treating head oil and dandruff and preparation method thereof
CN104138499B (en) A kind of Chinese medicine composition, its preparation method and its application for treating tinea of feet and hands and onychomycosis
CN107050209A (en) For treating alopecia areata Chinese medicine composition, leaching liquor and preparation method and medicated soap
CN104524479B (en) A kind of Chinese medicine composition for treating premenstrual syndrome and preparation method thereof
CN105997741A (en) Traditional Chinese medicine mask for treating acne and preparation method of traditional Chinese medicine mask
CN108686107B (en) Chinese herbal medicine composition for promoting hair growth, preparation method and application thereof
CN109924553A (en) A kind of Chinese herbal medicine socks for preventing and treating tinea pedis
CN109528865A (en) It is a kind of for treating the Chinese materia medica preparation and preparation method thereof of person in middle and old age's ophthalmology disease
CN109288947A (en) A kind of strong skin water formula and preparation method with detumescence removing miliaria and relieving itching function
CN108619410A (en) A kind of Mt. Ai spirit Ai Aicao essential oils and its extraction process
CN108524886A (en) A kind of tinea of feet and hands drug paste and preparation method thereof
CN113559195B (en) Externally-applied hemorrhoid medicine, hemorrhoid steam lotion and preparation method thereof
CN107198689A (en) Tetraodotoxin pharmaceutical composition and externally applied drug for treating antalgesic
KR101988010B1 (en) Composition of fumigation apparatus for treating female disease and method for manufacturing thereof
CN105326754A (en) Food grade additive-free acne-removal nourishing mung bean mask and green production method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20190409

RJ01 Rejection of invention patent application after publication