CN109567199A - A kind of health food compound combination and its preparation method and application with norcholesterol - Google Patents
A kind of health food compound combination and its preparation method and application with norcholesterol Download PDFInfo
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- CN109567199A CN109567199A CN201811588100.5A CN201811588100A CN109567199A CN 109567199 A CN109567199 A CN 109567199A CN 201811588100 A CN201811588100 A CN 201811588100A CN 109567199 A CN109567199 A CN 109567199A
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- norcholesterol
- health food
- compound combination
- cholesterol
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Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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Landscapes
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- Medicines Containing Plant Substances (AREA)
Abstract
Health food compound combination for having effects that norcholesterol the invention discloses a kind of and its preparation method and application, the combination primary raw material and corresponding mass part are as follows: 25-35 parts of whitewood spiceleaf, 10-20 parts of line leaf broom top, sorrow are escaped 5-15 parts careless, 20-30 parts of green brick tea, 10-20 parts of cassia seed, 5-15 parts of passion fruit；The preparation method is as follows: step 1, preparation whitewood spiceleaf, line leaf broom top, sorrow are escaped grass, green brick tea alcohol extracting thing: step 2, being processed cassia seed: step 3, being prepared passion fruit fruit juice；Step 4, will obtained by step 1 gained supernatant, step 2 processing liquid and step 3 gained fruit fruit juice be uniformly mixed, be concentrated, crushed after being dried, sterilizing to get.Application of the above-mentioned health food compound combination with norcholesterol in field of beverage.The composition inhibits cholesterol esterase activity using natural plant composition as raw material, reduces solubility of the cholesterol in small intestine micella, reduces absorption of the small intestine to cholesterol.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of health food compound with norcholesterol
Combination and its preparation method and application.
Background technique
People's eating and drinking without temperance system is the main reason for causing cholesterol levels excessively high at present, and cholesterol levels are excessively high to be will lead to
Coronary heart disease causes a series of complication such as hyperlipidemia, hyperglycemia and hypertension, seriously affects people's health.Therefore, gallbladder is maintained
Sterol is of great significance in the level for being suitable for for improving national health.The clinical drug for reducing cholesterol is mainly for he at present
The Western medicine such as spit of fland class, fibrates are easy to produce drug dependence, on the other hand can draw although having certain therapeutic effect
Play side effect, such as digestive tract reaction, flush and itch etc..Therefore a kind of safe and healthy green norcholesterol food is developed
Product, it is excessively high for prevention cholesterol, make people that good health states be kept to be of great significance.
Summary of the invention
For the deficiency of existing issue, has effects that the health care of norcholesterol the first purpose of the invention is to provide a kind of
The combination of food compound；Side effect and the single traditional Chinese medicine ingredients target for overcoming Western medicine are single, the unconspicuous feature of effect.This is green
Color healthy food maintains original effective component, has the characteristics of more targets, Small side effects, is conducive to people and keeps good body
Health status.
A second object of the present invention is to provide a kind of preparations of health food compound combination with norcholesterol
Method.
Third object of the present invention is to provide a kind of applications of health food compound combination with norcholesterol.
The technical solution used to solve the technical problems of the present invention is that:
A kind of health food compound combination with norcholesterol, primary raw material and corresponding parts by weight are as follows: whitewood
25-35 parts of spiceleaf, 10-20 parts of line leaf broom top, sorrow are escaped 5-15 parts careless, 20-30 parts of green brick tea, 10-20 parts of cassia seed, passion fruit
5-15 parts.
A kind of preparation method of the health food compound combination with norcholesterol, comprises the following specific steps that:
Step 1, whitewood spiceleaf is prepared, line leaf broom top, sorrow are escaped grass, green brick tea alcohol extracting thing:
By formula weigh whitewood spiceleaf, line leaf broom top, sorrow escape grass, green brick tea, be added ethyl alcohol, ultrasonic extraction 40min, mistake
Filter, obtains supernatant；
Step 2, cassia seed is processed:
Cassia seed is weighed by formula, distilled water is added, after decoction, filtering obtains supernatant i.e. cassia seed and processes liquid；
Step 3, passion fruit fruit juice:
After passion fruit deseeding, distilled water mashing is added in pulp, obtains passion fruit fruit juice；
Step 4, processing liquid and step 3 gained fruit juice obtained by step 1 gained supernatant, step 2 are uniformly mixed, are concentrated,
Crushed after being dried obtains extract powder, sterilizing to get.
As the optimal technical scheme of the application, in the step 1, whitewood spiceleaf, line leaf broom top, sorrow are weighed by formula
Escape grass, after green brick tea, first co-grinding, then the ethyl alcohol of 60%-80% volumetric concentration is added by solid-liquid ratio 1:5-10,50-80 DEG C
Ultrasonic extraction 40min；Ultrasonic power: 100-300W, filtering obtain supernatant.
As the optimal technical scheme of the application, in the step 2, the frying of cassia seed elder generation is decocted again, and when decoction presses
It takes care of liquor ratio 1:5-10 and distilled water is added, 80-100 DEG C of decoction 0.5-1h after filtering, obtains supernatant i.e. cassia seed and process liquid.
As the optimal technical scheme of the application, in the step 3, distilled water mashing is added according to solid-liquid ratio 1:3-5, obtains
To passion fruit fruit juice.
Application of the above-mentioned health food compound combination with norcholesterol in field of beverage.
Preferably, above-mentioned health food compound combination can be drunk separately as drink, can also be compound with other components
It is drunk as drink.
Beneficial effect
The present invention provides a kind of health food compound combination with norcholesterol, in compatibility each ingredient be food or
Integration of drinking and medicinal herbs substance takes nonhazardous effect for a long time.
Compound combination facilitates people and forms good eating habit, and cholesterol index is made to maintain growth level.
Each ingredient collaboration of compound reduces cholesterol: the cholesterol in food exists in the form of cholesteryl ester, cholesterol
Esterase can be hydrolyzed to cholesterol, just interior by small intestinal absorption into small intestine inner cholesterol micella.Whitewood spiceleaf, line leaf gold
Sparrow is colored, sorrow is escaped, and the careless flavones that is rich in can inhibit the activity of cholesterol esterase, so that the cholesteryl ester in food be inhibited to be hydrolyzed to
Free cholesterol；Green brick tea is rich in polyphenols, and tea polyphenols can reduce solubility of the cholesterol in micella, to press down
Small intestine processed is to cholesterol absorption.Cassia seed has the function of catharsis.Therefore the whitewood spiceleaf in compound, line leaf broom top, sorrow are escaped
Grass passes through the solubility for inhibiting cholesterol esterase and cholesterol in micella with green brick tea, cassia seed respectively, while it is solid to enhance gallbladder
Alcohol ester, which is led, lets out effect, reduces to concertedness absorption of the small intestine to cholesterol.The pleasant fragrance of passion fruit faint scent has the drink
There is strong fruity mouthfeel.
The present invention also provides a kind of preparation method of health food compound combination with norcholesterol, this method
The usage amount for reducing organic reagent, the effect of concentrating effect ingredient in raw material, enhance drink.
(1) whitewood spiceleaf: suspension culture of Aquilaria sinensis is Thymelaeceae agalloch eaglewood category aiphyllium, and resin lumber is used as medicine as agalloch eaglewood, is China
The exclusive source of traditional preciousness Chinese medicine agalloch eaglewood.With promoting qi circulation and relieving pain, the effect of warming middle energizer to arrest vomiting.Suspension culture of Aquilaria sinensis wild resource has been cited as
National second class protection wild plant.Whitewood spiceleaf is often used to treatment inflammation disease.It is listed in new raw-food material within 2018.In recent years
Come, whitewood spiceleaf is the dis-medicinal part of suspension culture of Aquilaria sinensis, and the teabag drink being made into is sold in the market.Flavones ingredient is in whitewood
Be distributed in fragrant leaf, fruit and trunk, be a kind of main ingredient in suspension culture of Aquilaria sinensis, have it is anti-oxidant, hypoglycemic, disappear
Scorching, reducing blood lipid and other effects.
(2) line leaf broom top: being classified as new raw-food material also known as South Africa tea by health ministry in line leaf broom top 2014,
Manufactured natural health drink line leaf broom top is decaffeinated after processing and oxalic acid, there is the effect of calm central nervous system；
Containing anti-oxidant flavonoids abundant and superoxide dismutase, to human free radical is removed, adjusts blood pressure lipid-loweringing and soften blood vessel, in advance
Prevent and control a variety of diseases to play significant curative effect, is a kind of natural, full plants organic products, is widely used.
(3) sorrow is escaped grass: scientific name crocodile mouth flower, is known as Sambucus thunbergiana in Hainan, and 2018 " new raw-food material, which terminates, examines catalogue "
Sorrow can be escaped grass as ordinary food and used by regulation.Be one kind be grown in equatorial low altitude area sparse woods or in shrubbery it is damp
Wild bush shape herbaceous plant in wet sandy soil, Flavonoid Content is abundant, inhibits growth of tumour cell.Enhance myocardial contraction
Ability improves blood pressure.Rich in a variety of nutrients needed by human, such as vitamin C, crude protein, dietary fiber, minerals.
With good medicinal or special medical value.
(4) green brick tea: green brick tea is using old green tea as raw material, and autoclave at high temperature forms after fermentation, rich in catechin, theanine and
Tea polysaccharide isoreactivity ingredient.Catechin can inhibit absorption of the enteron aisle to fat, reduce fat and accumulate in vivo, another aspect youngster
Cholesterol solubility in micella can be greatly lowered in theine, reduce absorption of the enteron aisle to cholesterol；Tea polysaccharide can inhibit
The activity of cholesterol esterase reduces enteron aisle inner cholesterol concentration；Body immunity can be enhanced in theanine.
(5) cassia seed: cassia seed is leguminous plant, sweet in flavor, bitter.With heat-clearing improving eyesight, the effect of relax bowel and defecation.Containing more
Sugar, protein, Chrysophanol and rheum emodin isoreactivity ingredient.Modern pharmacology shows that cassia seed can be reduced by leading the effect of letting out
Absorption of the enteron aisle to cholesterol, while adjustable immune, blood pressure lowering, adjusting blood lipid.
(6) passion fruit: Passifloraceae plant, it is sweet in flavor, sour, mild-natured；Fruit flesh many juice can add in the beverage, improve drink
The quality of material.Rich in 17 kinds of amino acid needed by human and multivitamin, exclusive active constituent " ultra-microfibers " can be with
Go deep into the discreet portions of stomach, harmful substance is cleared up in depths, improves intestinal microflora, has therapeutic effect to enteritis.Ultra micro is fine
Dimension can promote to drain, and prevent colon cancer, while can also inhibit absorption of the enteron aisle to metabolism of lipid and cholesterol, to play drop blood
Rouge reduces the effect of cholesterol.
Detailed description of the invention
Fig. 1 is the inhibitory effect of Examples 1 to 3 and blank control group to cholesterol esterase activity；
Fig. 2 is the inhibitory effect of Examples 1 to 3 and blank control group to cholesterol micella solubility.
Specific embodiment
The present invention is described in further details with reference to embodiments.Production is not specified in agents useful for same or instrument and equipment
Manufacturer, it is accordingly to be regarded as the conventional products that can be bought by market.
Embodiment 1
A kind of health food compound combination with norcholesterol, raw material and corresponding mass part are as follows: whitewood spiceleaf
25 parts, 18 parts of green brick tea, 18 parts of cassia seed, 10 parts of line leaf broom top, sorrow escape 5 parts, 7 parts of passion fruit of grass.
The preparation method comprises the following steps: take 25 parts of whitewood spiceleaf, 10 parts of line leaf broom top, sorrow escape grass 5 parts, 18 parts of green brick tea mixing, powder
After broken, in 1:5 times of ratio of solid-liquid ratio, 60% volume ethanol, 50 DEG C of ultrasounds extraction 40min, ultrasonic power 500w, filtering is added
Afterwards, supernatant is obtained.Cassia seed after frying is taken, in solid-liquid ratio 1:5 ratio, distilled water is added, 80 DEG C of decoction 1h after filtering, are obtained
Clear liquid, that is, cassia seed processes liquid.After passion fruit deseeding, pulp is added distilled water according to solid-liquid ratio 1:3 and is beaten, and obtains passion fruit fruit
Juice.Escape grass, green brick tea alcohol extract, cassia seed of whitewood spiceleaf, line leaf broom top, sorrow is processed liquid and passion fruit fruit juice and mixed
Afterwards, rotavapor under vacuum is concentrated under reduced pressure, and 50 DEG C of thickening temperature.Crushed after being dried obtains extract powder.Co60- gamma Rays go out
Bacterium obtains the powdered health food compound combination of sterile solid.
Compound combination can be drunk separately as drink, can also be drunk with the compound conduct drink of other components.
Embodiment 2
A kind of health food compound combination with norcholesterol, raw material and corresponding mass part are as follows: whitewood spiceleaf
30 parts, 15 parts of line leaf broom top, 15 parts of cassia seed, sorrow escape careless 15 parts, 25 parts of green brick tea, 10 parts of passion fruit.
The preparation method comprises the following steps: take 30 parts of whitewood spiceleaf, 15 parts of line leaf broom top, sorrow escape grass 15 parts, 25 parts of green brick tea mixing, powder
After broken, in solid-liquid ratio 1:7 ratio, 70% volume ethanol is added, 60 DEG C of ultrasounds extract 40min, ultrasonic power 400w, after filtering,
Obtain supernatant.Cassia seed after frying is taken, in solid-liquid ratio 1:7 ratio, distilled water is added, 90 DEG C of decoction 0.7h after filtering, obtain supernatant
Liquid, that is, cassia seed processes liquid.After passion fruit deseeding, pulp is added distilled water according to solid-liquid ratio 1:4 and is beaten, and obtains passion fruit fruit juice.
Whitewood spiceleaf, line leaf broom top, sorrow are escaped into grass and green brick tea alcohol extract and cassia seed process liquid and after passion fruit fruit juice mixes,
Rotavapor under vacuum is concentrated under reduced pressure, and 50 DEG C of thickening temperature.Crushed after being dried obtains extract powder.The sterilizing of Co60- gamma Rays, obtains
The health food compound combination powdered to sterile solid.
Compound combination can be drunk separately as drink, can also be drunk with the compound conduct drink of other components.
Embodiment 3
A kind of health food compound combination with norcholesterol, raw material and corresponding mass part are as follows: for suspension culture of Aquilaria sinensis
35 parts of leaf, 20 parts of line leaf broom top, 20 parts of cassia seed, sorrow are escaped careless 10 parts, 30 parts of green brick tea, 15 parts of passion fruit.
The preparation method comprises the following steps: take 35 parts of whitewood spiceleaf, 20 parts of line leaf broom top, sorrow escape grass 10 parts, 30 parts of green brick tea mixing, powder
After broken, in solid-liquid ratio 1:10 ratio, 80% volume ethanol is added, 70 DEG C of ultrasounds extract 40min, ultrasonic power 300w, after filtering,
Obtain supernatant.Cassia seed after frying is taken, in solid-liquid ratio 1:10 ratio, distilled water is added, 100 DEG C of decoction 0.5h after filtering, are obtained
Clear liquid, that is, cassia seed processes liquid.After passion fruit deseeding, pulp is added distilled water according to solid-liquid ratio 1:5 and is beaten, and obtains passion fruit fruit
Juice.Whitewood spiceleaf, line leaf broom top, sorrow are escaped grass and green brick tea alcohol extract and cassia seed process liquid and passion fruit fruit juice mixes
Afterwards, rotavapor under vacuum is concentrated under reduced pressure, and 50 DEG C of thickening temperature.Crushed after being dried obtains extract powder.Co60- gamma Rays go out
Bacterium obtains the powdered health food compound combination of sterile solid.
Compound combination can be drunk separately as drink, can also be drunk with the compound conduct drink of other components.
The combination is escaped the flavones that is rich in of grass using natural plant composition as raw material by whitewood spiceleaf, line leaf broom top, sorrow
Inhibit cholesterol esterase activity, green brick tea reduces solubility of the cholesterol in small intestine micella, and effect is let out in leading for cassia seed, respectively at
Concertedness effect is divided to reduce absorption of the small intestine to cholesterol.It is added to the pleasant fruit ingredient of fruity simultaneously, is reducing internal gallbladder
Sterol while maintaining cholesterol optimal level, improves drink mouthfeel.
Performance test
To the combination of health food compound obtained by Examples 1 to 3, with 70% ethyl alcohol, 80 DEG C of extraction 2h, filtering obtains supernatant,
Rotary Evaporators concentration, obtains powder after vacuum drying.
(1) cholesterol esterase activity
Test temperature is maintained at 25.0 DEG C.All reactions are containing NaCl (0.1mol/L), natrium taurocholicum
(5.16mmol/L), the sodium phosphate buffer (0.1mol/L pH 7.0) of p-nitrophenyl butyrate (PNPB, 0.2mmol/L)
Middle progress.Cholesterol esterase is first dissolved in high purity water in advance, concentration 20ug/mL；Substrate PNPB and inhibitor are first dissolved in advance
In acetonitrile, saved at -20 DEG C.Pig pancreatic cholesterol esterase (0.72U/mL) starting reaction is added, while Examples 1 to 3 is added
Health food compound combine alcohol extract, concentration is 3mg/mL (distilled water is added in blank, and other conditions are constant), 25.0 DEG C of reactions
5min, ultraviolet-uisible spectrophotometer detect absorbance in 405nm.
Inhibiting rate=(blank solution light absorption value-sample sets light absorption value)/blank solution light absorption value
As seen from Figure 1, compound combination can inhibit the activity of cholesterol esterase by force very much, reduce cholesterol in food
Ester is decomposed into free cholesterol, prevents absorption of the small intestine to free cholesterol.
(2) cholesterol micella solubility inhibiting rate effect
Compound combination is to the detection process of cholesterol micella solubility impact effect: 1L micellar solution is first configured,
In, taurocholate na concn is 10mmol/L, cholesterol 2mmol/L, oleic acid 5mmol/L, NaCl 132mmol/L, phosphorus
Acid buffer is 15mmol/L.37 DEG C of standings overnight.Then it is (empty that 0.1-0.8mg/ml galic essential oil is separately added into centrifuge tube
It is white to be not added), it is placed on 37 DEG C and shakes bed reaction 30min, and in 8000rpm centrifuge, be centrifuged 2min.Take supernatant in 2mL new
In centrifuge tube, while 100uL cholesterin detection reagent is drawn in same centrifuge tube with liquid-transfering gun, be sufficiently mixed, after 5min,
It is detected in the ultraviolet specrophotometer of 405nm, measures cholesterol level in micella.
The micellar solution inner cholesterol dissolution of health food compound combination alcohol extract (2mg/mL) of Examples 1 to 3 is added
Spend low, micellar solution inner cholesterol solubility height in blank centrifuge tube, the health food compound combination alcohol extract of Examples 1 to 3
Inhibit cholesterol interior dissolution in micella.
The inhibiting rate of galic essential oil is indicated with the formula of inhibiting rate.
Inhibiting rate=(cholesterol solubility-sample solution cholesterol solubility of blank solution)/blank solution gallbladder
Sterol solubility
As seen from Figure 2, compound combination can inhibit cholesterol to dissolve in micella very much by force, and free cholesterol is not
It can be dissolved in micella, small intestine cannot absorb cholesterol, and the cholesterol not dissolved finally is discharged with stool form from internal.
(3) zoopery
Using Wistar rat as experimental subjects, it is divided into 5 groups, 3 groups of embodiment, hyperlipidemia model group and blank control group, every group 8
Rat.Blank control group gives normal diet；High in fat group and embodiment group give high lipid food.Meanwhile blank control group and
High in fat group with water stomach-filling 4 weeks, embodiment 1-3 group gives the compound combination of preparation, continuous gavage 4 weeks, etherization execution rat,
Heart extracting blood measures triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low in serum
The concentration of density lipoprotein-cholesterol (LDL-C).The processing of spass software data, the results are shown in Table 1:
Influence of the 1. embodiment 1-3 of table to rat fat and cholesterol
As can be seen from Table 1, TG, TC, LDL-C value of embodiment 1,2,3 are lower than high in fat group, and HDL-C is higher than control group；It is real
It applies 1,2,3 excrement inner cholesterol content of example and is apparently higher than high in fat group.The combination of this compound can promote food inner cholesterol to be discharged, tool
There is reduction cholesterol, reduces the effect of blood lipid.
Protection content of the invention is not limited to above embodiments.Without departing from the spirit and scope of the invention, originally
Field technical staff it is conceivable that variation and advantage be all included in the present invention, and with the attached claims be protection
Range.
Claims (6)
1. a kind of health food compound combination with norcholesterol, which is characterized in that primary raw material and corresponding mass part
As follows: 25-35 parts of whitewood spiceleaf, 10-20 parts of line leaf broom top, sorrow are escaped 5-15 parts careless, 20-30 parts of green brick tea, cassia seed 10-20
Part, 5-15 parts of passion fruit.
2. the preparation method of the health food compound combination with norcholesterol described in claim 1, which is characterized in that
It comprises the following specific steps that:
Step 1, whitewood spiceleaf is prepared, line leaf broom top, sorrow are escaped grass, green brick tea alcohol extracting thing:
By formula weigh whitewood spiceleaf, line leaf broom top, sorrow escape grass, green brick tea, be added ethyl alcohol, 40 min of ultrasonic extraction, filtering,
Obtain supernatant；
Step 2, cassia seed is processed:
Cassia seed is weighed by formula, distilled water is added, after decoction, filtering obtains supernatant i.e. cassia seed and processes liquid；
Step 3, passion fruit fruit juice:
After passion fruit deseeding, distilled water mashing is added in pulp, obtains passion fruit fruit juice；
Step 4, processing liquid and step 3 gained fruit juice obtained by step 1 gained supernatant, step 2 are uniformly mixed, are concentrated, it is dry
After crush to obtain extract powder, sterilizing to get.
3. the preparation method of the health food compound combination with norcholesterol according to claim 2, feature
Be, in the step 1, by formula weigh whitewood spiceleaf, line leaf broom top, sorrow escape grass, after green brick tea, first co-grinding, then
The ethyl alcohol of 60%-80% volumetric concentration, 50-80 DEG C of 40 min of ultrasonic extraction are added by solid-liquid ratio 1:5-10；Ultrasonic power: 100-
300 W, filtering, obtain supernatant.
4. the preparation method of the health food compound combination with norcholesterol according to claim 2, feature
It is, in the step 2, the frying of cassia seed elder generation is decocted again, and distilled water, 80- is added according to solid-liquid ratio 1:5-10 when decoction
100 DEG C of decoction 0.5-1 h after filtering, obtain supernatant i.e. cassia seed and process liquid.
5. the preparation method of the health food compound combination with norcholesterol according to claim 2, feature
It is, in the step 3, distilled water mashing is added according to solid-liquid ratio 1:3-5, obtains passion fruit fruit juice.
6. the health food compound combination with norcholesterol described in claim 1 is in the application of field of beverage.
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