KR100701336B1 - Herb or alcohol for tonic or jeongjeong and its manufacturing method - Google Patents
Herb or alcohol for tonic or jeongjeong and its manufacturing method Download PDFInfo
- Publication number
- KR100701336B1 KR100701336B1 KR1020050051776A KR20050051776A KR100701336B1 KR 100701336 B1 KR100701336 B1 KR 100701336B1 KR 1020050051776 A KR1020050051776 A KR 1020050051776A KR 20050051776 A KR20050051776 A KR 20050051776A KR 100701336 B1 KR100701336 B1 KR 100701336B1
- Authority
- KR
- South Korea
- Prior art keywords
- tonic
- herbal
- glutathione
- herbal medicine
- ginseng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001256 tonic effect Effects 0.000 title claims abstract description 29
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title description 7
- 241000411851 herbal medicine Species 0.000 claims abstract description 34
- 235000014101 wine Nutrition 0.000 claims abstract description 27
- 235000008434 ginseng Nutrition 0.000 claims abstract description 21
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 20
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 20
- 241000675108 Citrus tangerina Species 0.000 claims abstract description 19
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 19
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims abstract description 19
- 244000223014 Syzygium aromaticum Species 0.000 claims abstract description 19
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 18
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 18
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 18
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims abstract description 18
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 18
- 235000008397 ginger Nutrition 0.000 claims abstract description 18
- 229940010454 licorice Drugs 0.000 claims abstract description 18
- 241000287828 Gallus gallus Species 0.000 claims abstract description 17
- 244000273928 Zingiber officinale Species 0.000 claims abstract description 16
- 235000006533 astragalus Nutrition 0.000 claims abstract description 16
- 235000013527 bean curd Nutrition 0.000 claims abstract description 16
- 241001061264 Astragalus Species 0.000 claims abstract description 14
- 210000004233 talus Anatomy 0.000 claims abstract description 14
- 240000002045 Guettarda speciosa Species 0.000 claims abstract description 12
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 12
- 241001116389 Aloe Species 0.000 claims abstract description 6
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 5
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract 4
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract 4
- 238000000855 fermentation Methods 0.000 claims description 16
- 230000004151 fermentation Effects 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 15
- 230000032683 aging Effects 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000009928 pasteurization Methods 0.000 claims description 4
- 238000009628 steelmaking Methods 0.000 claims 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract description 39
- 229960003180 glutathione Drugs 0.000 abstract description 19
- 108010024636 Glutathione Proteins 0.000 abstract description 18
- 239000003814 drug Substances 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 11
- 210000004185 liver Anatomy 0.000 abstract description 7
- 229940124595 oriental medicine Drugs 0.000 abstract description 5
- 238000001784 detoxification Methods 0.000 abstract description 4
- 208000019423 liver disease Diseases 0.000 abstract description 3
- 230000003908 liver function Effects 0.000 abstract description 2
- 238000011084 recovery Methods 0.000 abstract description 2
- 240000004371 Panax ginseng Species 0.000 description 17
- 239000000341 volatile oil Substances 0.000 description 15
- 241000202807 Glycyrrhiza Species 0.000 description 14
- 241000196324 Embryophyta Species 0.000 description 8
- 235000019441 ethanol Nutrition 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 206010047700 Vomiting Diseases 0.000 description 5
- 229930013930 alkaloid Natural products 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 230000008673 vomiting Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229910000831 Steel Inorganic materials 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000010959 steel Substances 0.000 description 4
- 241000208838 Asteraceae Species 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 208000005171 Dysmenorrhea Diseases 0.000 description 3
- 206010013935 Dysmenorrhoea Diseases 0.000 description 3
- 206010019133 Hangover Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 210000000554 iris Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 230000001568 sexual effect Effects 0.000 description 3
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N D-Maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 229920001202 Inulin Polymers 0.000 description 2
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
- 235000011613 Pinus brutia Nutrition 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 241000220222 Rosaceae Species 0.000 description 2
- 241000234314 Zingiber Species 0.000 description 2
- KGEKLUUHTZCSIP-HOSYDEDBSA-N [(1s,4s,6r)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Chemical compound C1C[C@]2(C)[C@H](OC(=O)C)C[C@H]1C2(C)C KGEKLUUHTZCSIP-HOSYDEDBSA-N 0.000 description 2
- 238000010564 aerobic fermentation Methods 0.000 description 2
- 235000013334 alcoholic beverage Nutrition 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 235000019568 aromas Nutrition 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- AKGGYBADQZYZPD-UHFFFAOYSA-N benzylacetone Chemical compound CC(=O)CCC1=CC=CC=C1 AKGGYBADQZYZPD-UHFFFAOYSA-N 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 235000001671 coumarin Nutrition 0.000 description 2
- 150000004775 coumarins Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 230000001856 erectile effect Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
- 229940029339 inulin Drugs 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000007102 metabolic function Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 239000009536 samultang Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- 239000007218 ym medium Substances 0.000 description 2
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 description 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- KIUMMUBSPKGMOY-UHFFFAOYSA-N 3,3'-Dithiobis(6-nitrobenzoic acid) Chemical compound C1=C([N+]([O-])=O)C(C(=O)O)=CC(SSC=2C=C(C(=CC=2)[N+]([O-])=O)C(O)=O)=C1 KIUMMUBSPKGMOY-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- JRJGKUTZNBZHNK-UHFFFAOYSA-N 3-phenylpropyl acetate Chemical compound CC(=O)OCCCC1=CC=CC=C1 JRJGKUTZNBZHNK-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241001143500 Aceraceae Species 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241001346320 Amomum villosum var. xanthioides Species 0.000 description 1
- 235000016500 Amomum xanthioides Nutrition 0.000 description 1
- 241001465677 Ancylostomatoidea Species 0.000 description 1
- 235000018865 Angelica gigas Nutrition 0.000 description 1
- 240000001810 Angelica gigas Species 0.000 description 1
- 241000271307 Aquilaria malaccensis Species 0.000 description 1
- DJHGAFSJWGLOIV-UHFFFAOYSA-N Arsenic acid Chemical compound O[As](O)(O)=O DJHGAFSJWGLOIV-UHFFFAOYSA-N 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 241000045403 Astragalus propinquus Species 0.000 description 1
- FBMORZZOJSDNRQ-GLQYFDAESA-N Atractylenolide III Chemical compound C=C([C@@H]1C2)CCC[C@]1(C)C[C@@]1(O)C2=C(C)C(=O)O1 FBMORZZOJSDNRQ-GLQYFDAESA-N 0.000 description 1
- 241000132011 Atractylodes lancea Species 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010048909 Boredom Diseases 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 241000533367 Cnidium officinale Species 0.000 description 1
- 206010009866 Cold sweat Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 description 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 description 1
- 235000009685 Crataegus X maligna Nutrition 0.000 description 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 description 1
- 235000009486 Crataegus bullatus Nutrition 0.000 description 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 description 1
- 235000009682 Crataegus limnophila Nutrition 0.000 description 1
- 240000000171 Crataegus monogyna Species 0.000 description 1
- 235000004423 Crataegus monogyna Nutrition 0.000 description 1
- 235000002313 Crataegus paludosa Nutrition 0.000 description 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- CUKSFECWKQBVED-INIZCTEOSA-N Decursin Chemical compound C1=CC(=O)OC2=C1C=C1C[C@H](OC(=O)C=C(C)C)C(C)(C)OC1=C2 CUKSFECWKQBVED-INIZCTEOSA-N 0.000 description 1
- BGXFQDFSVDZUIW-UHFFFAOYSA-N Decursinol Natural products O1C(=O)C=CC2=C1C=C1OC(C)(C)C(O)CC1=C2 BGXFQDFSVDZUIW-UHFFFAOYSA-N 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000266331 Eugenia Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010053070 Glutathione Disulfide Proteins 0.000 description 1
- 108010063907 Glutathione Reductase Proteins 0.000 description 1
- 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- CUKSFECWKQBVED-UHFFFAOYSA-N Grandivittin Natural products C1=CC(=O)OC2=C1C=C1CC(OC(=O)C=C(C)C)C(C)(C)OC1=C2 CUKSFECWKQBVED-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000002598 Inula helenium Nutrition 0.000 description 1
- 244000116484 Inula helenium Species 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 description 1
- HXCGUCZXPFBNRD-DNLMCPORSA-N Nodakenin Chemical compound CC(C)([C@@H]1OC2=CC=3OC(=O)C=CC=3C=C2C1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HXCGUCZXPFBNRD-DNLMCPORSA-N 0.000 description 1
- HXCGUCZXPFBNRD-QVYYAULWSA-N Nodakenin Natural products O(C(C)(C)[C@@H]1Oc2c(cc3c(OC(=O)C=C3)c2)C1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HXCGUCZXPFBNRD-QVYYAULWSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000736199 Paeonia Species 0.000 description 1
- 241000124501 Paeonia obovata var. japonica Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 244000220503 Persea thunbergii Species 0.000 description 1
- 235000004267 Persea thunbergii Nutrition 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 241001522232 Pinellia ternata Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 241000405911 Rehmannia glutinosa Species 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 241000208422 Rhododendron Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 206010041235 Snoring Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- BLGXFZZNTVWLAY-CCZXDCJGSA-N Yohimbine Natural products C1=CC=C2C(CCN3C[C@@H]4CC[C@@H](O)[C@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-CCZXDCJGSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003048 aphrodisiac agent Substances 0.000 description 1
- 230000002509 aphrodisiac effect Effects 0.000 description 1
- 229940000488 arsenic acid Drugs 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- BLGXFZZNTVWLAY-UHFFFAOYSA-N beta-Yohimbin Natural products C1=CC=C2C(CCN3CC4CCC(O)C(C4CC33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940115397 bornyl acetate Drugs 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 235000005300 cardamomo Nutrition 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- SERARPRVBWDEBA-GXDHUFHOSA-N chembl1994738 Chemical compound OC1=CC=CC=C1\C=N\NC1=CC=CC=C1 SERARPRVBWDEBA-GXDHUFHOSA-N 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 235000004634 cranberry Nutrition 0.000 description 1
- 235000021438 curry Nutrition 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- JXZWWIMXTVJNSF-UHFFFAOYSA-N decursin Natural products CC(=CC(=O)OC1Oc2cc3OC(=O)C=Cc3cc2CC1(C)C)C JXZWWIMXTVJNSF-UHFFFAOYSA-N 0.000 description 1
- BGXFQDFSVDZUIW-LBPRGKRZSA-N decursinol Chemical compound O1C(=O)C=CC2=C1C=C1OC(C)(C)[C@@H](O)CC1=C2 BGXFQDFSVDZUIW-LBPRGKRZSA-N 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 244000237330 gutta percha tree Species 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000010198 maturation time Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 description 1
- HXCGUCZXPFBNRD-UHFFFAOYSA-N nodakenine Natural products C1C2=CC=3C=CC(=O)OC=3C=C2OC1C(C)(C)OC1OC(CO)C(O)C(O)C1O HXCGUCZXPFBNRD-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000021090 palsy Diseases 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 235000010204 pine bark Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 208000018316 severe headache Diseases 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 230000035946 sexual desire Effects 0.000 description 1
- 230000035936 sexual power Effects 0.000 description 1
- 235000020083 shōchū Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000007103 stamina Effects 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- -1 thiol compound Chemical class 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
- 229960000317 yohimbine Drugs 0.000 description 1
- AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/02—Preparation of other alcoholic beverages by fermentation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
본 발명은 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향을 글루타치온 생성능을 갖고 있는 사카로마이세스 세레비지애(Saccharomyces cerevisiae) FF-8 KACC 93023P을 이용하여 발효시킨 강장 또는 강정용 한방주 및 이의 제조방법에 관한 것으로서, 상세하게는 본 발명의 한방주에서 이용되는 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향이 생약 건조 중량을 기준으로 4-5:4-5:2-3:4-5:2-3:2-3:4-5:2-3:4-5:2-3:2-3:4-5:4-5:4-5:2-3:2-3:4-5:2-3:2-3:1-2의 비율로 구성되어 글루타치온 생성능을 갖고 있는 사카로마이세스 세레비지애 FF-8 KACC 93023P을 이용하여 발효시킨 것으로서 강장 또는 강정용에 효과적인 한방주이다. 또한 글루타치온은 현재 의약분야에서 간질환 치료제, 간기능 회복 및 해독작용 등에 이용되고 있기에 본 발명의 한방주에서 사용하는 사카로마이세스 세리비지애 FF-8 KACC 93023P은 이러한 글루타치온을 생성할 수 있어 본 발명의 한방주는 간 보호에도 유용한 효과를 갖는다.The present invention is sakalo that has glutathione-producing ability of Angelica, Cheongung, Baekja, Baekjak, Astragalus, Broiler, Sukjihwang, Licorice, Baekbokyeong, Baekdugu, Barn, Baekchul, Tangerine Red, Ginseng, Aloe, Mokji, Tofu, Gakyu, Ginger and Clove. It relates to the tonic or gangjung herbal wine fermented with Saccharomyces cerevisiae FF-8 KACC 93023P, and a method for preparing the same. , Astragalus, Broiler, Sukjihwang, Licorice, Baekbokryeong, Baekdugu, Barn, Baekchul, Tangerine Red, Ginseng, Aroma, Mokji, Tofu, Gakcho, Ginger and Clove 4-5: 4-5: 2-3 : 4-5: 2-3: 2-3: 4-5: 2-3: 4-5: 2-3: 2-3: 4-5: 4-5: 4-5: 2-3: 2 Fermented with Saccharomyces cerevisiae FF-8 KACC 93023P, consisting of -3: 4-5: 2-3: 2-3: 1-2 and having glutathione production capacity Effective herbal medicine . In addition, since glutathione is currently used in the treatment of liver disease, liver function recovery, and detoxification in medicine, Saccharomyces cerevisiae FF-8 KACC 93023P used in the herbal medicine of the present invention can generate such glutathione. The herbal medicine of the present invention also has a useful effect in protecting the liver.
강장용, 강정용, 한방주, 당귀, 천궁, 글루타치온 Tonic, Gangjeong, Oriental Medicine, Angelica, Cheongung, Glutathione
Description
본 발명은 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향을 글루타치온 생성능을 갖는 사카로마이세스 세레비지애(Saccharomyces cerevisiae) FF-8 KACC 93023P을 이용하여 발효시킨 강장 또는 강정용 한방주 및 이의 제조방법에 관한 것이다.The present invention is Saccharomyc, Ginseng, Cheongung, Banja, Earl, Astragalus, Broiler, Sukjiwang, Licorice, Baekbokyeong, Baekdugu, Barn, Baekchul, Tangerine Hong, Ginseng, Aroma, Mokji, Tofu, Gurak, Ginger and Clove with saccharion production ability It relates to a tonic or gangbang herbal wine fermented using Saccharomyces cerevisiae FF-8 KACC 93023P and a method for producing the same.
술은 인류의 문명과 더불어 만들어지고 발전되어 온 것으로서, 그 제조방법 및 재료에 따라 여러 분류로 나뉘어 지고 있다. 특히 우리나라는 고대로부터 음식물의 발효와 숙성기술이 발달해 왔으므로, 전통주로 이를 이용하여 제조된 것이 거의 전부이다. 종래의 전통주는 제조방법에 따라 양조주, 증류주, 혼양주 및 혼성주로 구분되었으며, 사용되는 재료에 따라 순곡주와 약용가향곡주로 구분된다. 이 중, 순곡주는 제조공정에 따라 단양주, 이양주 및 삼양주로 나뉘며, 숙성기간에 따라 일반주와 속성주로 나뉜다. 이러한 전통주는 각 지방에 따라 가내수공업적인 방법으로 소량 제조되므로, 소주나 맥주 등과 같이 대량으로 값싸게 생산되는 주류나 비싼 외국산 수입주류에 제자리를 잃어가고 있다. 물론, 막걸리나 동동주처럼 대중적으로 널리 퍼진 것도 있으나, 전통주 본연의 풍미를 잃어가고 있어 이제는 전통주라고 할 수도 없는 실정이다.Alcohol has been made and developed along with human civilization, and is divided into several categories according to its manufacturing method and materials. In particular, since Korea has been developing fermentation and maturation of food from ancient times, almost all of them are manufactured using traditional liquor. Conventional traditional liquor was classified into brew, distilled liquor, mixed liquor and mixed liquor according to the manufacturing method, and divided into pure grain liquor and medicinal flavored liquor liquor according to the materials used. Among them, pure grain wine is divided into Danyangju, Leeyangju and Samyangju according to the manufacturing process, and is divided into general and fast-growing liquors depending on the ripening period. Since traditional liquor is produced in small quantities by domestic manufacturing methods according to each province, it is losing its place in large quantities of cheaply produced liquor such as shochu or beer or expensive foreign imported liquor. Of course, there are some that are popularly spread like makgeolli and Dongdongju, but the traditional flavor of the traditional liquor is being lost.
그러나 근래에 들어 생활수준의 향상과 더불어 주류를 찾는 소비자들은 주류를 즐기는 동시에 맛과 향이 독특하고 특별한 기능성을 갖는 술을 원하는 추세에 있는 바, 특히 건강 및 보양에 대한 관심의 증가로 음주와 더불어 약용기능을 기대할 수 있는 술의 개발이 절실히 요구되었으며, 전통주 중에서 약용가향곡주류가 특히 호평을 받게 되었다. 이들은 술을 제조하는 재료에 약용식물이나 가향재료 등을 첨가하여 제조된 술이므로, 제조된 술이 약리작용 또는 독특한 향미를 함유하게 된다. 이 중 일반적으로 널리 알려진 것으로는 오가피주, 두견주, 연엽주, 문배주 등이 있다.However, in recent years, consumers looking for alcoholic beverages along with the improvement of living standards tend to enjoy alcoholic beverages while having a unique taste and aroma and special functionalities. The development of alcohol that can be expected is urgently needed, and medicinal flavored alcoholic liquor is especially popular among traditional liquors. Since these are liquor made by adding medicinal plants or flavoring materials to the liquor making material, the liquor produced contains pharmacological action or unique flavor. Among these, generally widely known are organza wine, head wine, lotus wine, munbaeju and the like.
전기한 전통주는 제조방법에 따라 크게 전통 증류주와 전통 발효주로 나뉘어지며, 특히 전통발효주는 첨가된 재료에 따라 맛과 향이 독특하고 각기 개성적인 기능성을 함유하지만 전통발효주의 특성상 누룩을 사용하여 술을 제조하게 되므로 누룩 본연의 맛과 향을 지니게 되어 이에 익숙하지 않은 소비자들로부터 외면하고 있으며, 전통발효주의 특성상 숙성시간이 길수록 더욱 더 깊은 맛을 내지만, 밀폐되지 않은 술은 쉽게 변질될 가능성이 높아 유통기한이 짧다는 단점이 있다. 이런 단점을 극복하기 위하여 숙성된 전통발효주를 가공하기도 하지만, 이는 숙성된 전통발효주 특유의 향미 또는 각각의 개성적인 기능성을 일부 손실하는 결과를 초래하게 된다. 또한 전통발효주의 제조에 있어서 보당원 등의 화학물질을 첨가하거나 심지어는 각종 화학주를 혼합하는 경우도 있어 전통 발효주라는 말이 무색할 지경이다. The traditional liquor is divided into traditional distilled liquor and traditional fermented liquor according to the manufacturing method.In particular, traditional fermented liquor is unique in taste and aroma and contains unique functionalities depending on the ingredients added. Because it has the taste and aroma of yeast, it is neglected by consumers who are not familiar with it.In the nature of traditional fermentation, the longer the maturation time, the deeper the taste, but the unsealed liquor is easily changed. The disadvantage is that the deadline is short. In order to overcome this disadvantage, the traditional fermented liquor is processed, but this results in the loss of the unique flavor of each traditional fermented liquor. In addition, in the production of traditional fermented wine, the addition of chemicals such as Bodangwon or even mixed with various chemical wines, the term traditional fermented wine is about to be colorless.
당귀(Angelica gigas Nakai)는 쌍떡잎식물 산형화목 미나리과의 여러해살이풀로서, 뿌리에는 쿠마린성분 2-3%, 데쿠르신, 데쿠르시놀 등의 피라노쿠마린, 노다케네틴, 움벨리페론, 노다케닌, 정유, 수지 등이 함유되어 있다. 뿌리의 정유성분은 진정작용을 하며, 쿠마린 성분은 혈압강하작용을 하며, 당귀는 한방에서 월경불순, 월경아픔, 자궁발육부전 등에 이용되고 있다. Angelica gigas Nakai is a perennial herb of the dicotyledonous plant Asteraceae, whose roots include 2-3% coumarin, pyranokumarins such as decursin and decursinol, nodakenetine, umbeliferon, nodakenin, Essential oils, resins, and the like. Essential oils of the roots are sedating, coumarins are blood pressure-lowering, Angelica is used in menstruation, dysmenorrhea, dysmenorrhea and dysmenorrhea.
천궁(Cnidium officinale)은 쌍떡잎식물 이판화군 산형화목 미나리과의 여러해살이풀로서, 뿌리 및 뿌리줄기와 잎, 열매에는 정유, 쿠마린, 플라보노이드 등이 함유되어 있으며, 한방에서는 뿌리줄기를 진정, 진통에 효능이 있어 두통, 빈혈증, 부인병 등에 사용한다. Cnidium officinale is a perennial herb of the dicotyledonous foliaceae family Aceraceae, which contains essential oils, coumarins, and flavonoids in roots, roots, leaves, and fruits. It is used for headache, anemia, gynecology.
반하(Pinellia ternata)는 외떡잎식물 천남성목 천남성과의 여러해살이풀로서, 알뿌리에 독성이 있으나 한방에서는 거담·진해 등의 효능이 있어 구토, 설사, 임신중의 구토에 사용한다. Pinellia ternata is a perennial herb with a monocotyledonous plant, Chunnamseong Mok , Chunnamseong . It is toxic to roots, but it is used for vomiting, diarrhea and vomiting during pregnancy because it has the effect of expectoration and Jinhae.
백작약(Paeonia japonica)은 쌍떡잎식물 미나리아재비목 미나리아재비과의 여러해살이풀로서, 알칼로이드와 쿠마린, 아스파라긴 약 0.14%의 정유 5%의 안식향산, 살리찔산메틸에스테르, 살리찔산, 스테린, 탄닌질, 알콜, 수지가 함유되어 있으며, 뿌리를 진통·진경·부인병에 사용한다. Paeonia japonica is a perennial herb of the dicotyledonous plant of the genus Buttercupaceae, which is an alkaloid, coumarin, and asparagine. It is used for root pain, pain relief and women's diseases.
황기(Astragalus membranaceus)는 쌍떡잎식물 장미목 콩과의 여러해살이풀로서, 한국·일본·만주·중국 북동부·시베리아 동부 등지에 분포한다. 흔히 약초로 서 재배하며 한방에서는 가을에 채취하여 노두(蘆頭)와 잔뿌리를 제거하고 햇빛에 말린 것을 한약재의 황기라 하며, 지한(止汗)·이뇨(利尿)·소종(消腫) 등의 효능이 있어 신체허약·피로권태·기혈허탈(氣血虛脫)·탈항(脫肛)·자궁탈·내장하수·식은땀·말초신경 등에 처방한다. Astragalus membranaceus is a perennial herb of the dicotyledonous plant Rosaceae, distributed in Korea, Japan, Manchuria, northeastern China and eastern Siberia. It is often grown as a herb, and it is harvested in autumn in oriental medicine to remove outcrops and small roots, and dried in the sun. It is called Astragalus of Chinese herbal medicine. It is effective in physical weakness, fatigue, boredom, deprivation, deprivation, uterine deprivation, internal sewage, cold sweat, and peripheral nerves.
육계는 계피나무(Cinnamomum cassia Blume.)의 껍질을 의미하는 것으로서 정유 1-3.4%, 탄닌질 2-3%, 점액, 탄수화물 등이 함유되어 있으며, 정유의 주성분은 계피알데히드 75-90%, 찐나밀아세타트, 페닐프로필아세타트, 살리찔알데히드 등이다. 육계는 땀내기약, 열내림약, 진통제 등으로 사용된다.Broiler means the bark of Cinnamomum cassia Blume.It contains 1-3.4% of essential oils, 2-3% of tannins, mucus and carbohydrates.The main components of essential oils are 75-90% of cinnamon aldehyde and steamed namil. Acetate, phenylpropyl acetate, salicyaldehyde and the like. Broilers are used as sweating medicines, heat lowering medicines, and painkillers.
숙지황은 지황(Rehmannia glutinosa)의 뿌리를 쪄서 말린 한약재로서, 숙지황은 사물탕(四物湯)의 주요 약재이며 각종 만성병 중 몸이 허약하여 나타나는 내열(內熱), 인후건조(咽喉乾燥), 갈증 등의 증상에 쓰인다. 사물탕은 여성의 출산 후나 월경 등으로 인한 과다출혈, 허약, 어지럼증 등에 널리 쓰인다. 예로부터 허담(虛痰)을 치료하는 데 효과가 있어 차로 달여 마셨으며, 기침과 천식에 복령(茯笭)·반하(半夏) 등과 배합하여 사용한다.Sukjihwang is a Chinese herb dried from the roots of Rehmannia glutinosa . Sukjihwang is a major herb of Samul-tang, and it is heat-resistant, dry throat, and thirst caused by the weakness of various chronic diseases. Used for symptoms Samultang is widely used for women with excessive bleeding, weakness, and dizziness due to postpartum and menstruation. It has been effective in treating Hedam since ancient times, and it was drunk as a tea. It is used in combination with cough and asthma in Bokryeong and Banha.
감초(Glycyrrhiza uralensis)는 쌍떡잎식물 장미목 콩과의 여러해살이풀로서, 뿌리와 뿌리줄기에는 글리찌리진이 5-14%, 글라브라산 등이 함유되어 있다. 감초는 사탕의 약 40-50배의 단맛이 나며 거담작용이 있으며 호흡기도를 완화시키는 작용을 한다.Licorice ( Glycyrrhiza uralensis ) is a perennial herb of the dicotyledonous plant Rosaceae, with 5-14% glycirizine and glabraic acid in the root and root stem. Licorice is about 40-50 times sweeter than candy, has an expectorant effect and relieves respiratory tract.
백복령은 복령(Poria cocos Wolf.)의 균핵을 말린 것으로서, 흰솔풍령이라고도 한다. 벌목한지 3-4년 지난 소나무 뿌리에 기생하여 혹처럼 크게 자란 균핵으로 흔히 땅속 20-50cm깊이에 있다. 지름 30~50㎝ 쯤의 덩어리로 겉은 소나무 껍질처럼 거칠고 속은 희거나 분홍빛이 난다. 속이 흰 것은 백복령이라 하고 분홍빛인 것은 적복령이라고 하는데 백복령은 적송의 뿌리에 기생하고 적복령은 곰솔 뿌리에 기생한다. 그리고 솔뿌리를 둘러싼 것을 복신이라고 한다. 맛은 달고 심심하며 성질이 평(平)하여 보(補)하는 작용이 있고 이뇨작용을 하지만 강하지 않다. 폐경(肺經)·비경(脾經)·심경(心經)·신경(腎經)·방광경(膀胱經)에 작용하여 비장을 보하고 가래를 삭이며 정신을 안정시킨다. 약리실험 결과에 의하면 이뇨작용과 혈당량을 낮추는 작용, 진정작용 등을 하는 것으로 밝혀졌으며 면역 부활작용을 하는 것으로도 알려져 있다. 비장이 허(虛)하여 몸이 붓는 경우와 담음병에 사용한다. Baekbokyeong is the dried core of Poria cocos Wolf. It is a fungus that grows like a hump and grows in pine roots 3-4 years after harvesting and is usually 20-50cm deep in the ground. It is a mass about 30 ~ 50㎝ in diameter, rough on the outside like pine bark, white or pink inside. The white inside is called Baekbok-ryeong, and the pink one is called Red Bok-Ryeong. Baek-Bok-Ryeong is parasitic on the root of Red Song and Red-Bok-Ryeong is parasitic on the root of Gomsol. And what surrounds the pine root is called blessed. Taste is sweet and boring, and the nature of the flat (보) has a working effect and diuretic, but not strong. It works on menopause, parenteral, heart, nerve, and bladder to protect the spleen, sputum, and stabilize the mind. The results of pharmacological experiments have been shown to act as a diuretic, lowering blood sugar, sedation, and also known as an immune resurrection. Spleen swelling (虛) is used when the body swelling and Damyeong disease.
백두구(Amomum cardamomum L.)는 사철푸른 여러해살이풀로서, 그 열매를 약재로 사용하며 열매의 씨에는 2.4%의 정유가 함유되어 있으며, 정유의 주성분은 d-보르네올과 d-캄파이며, 방향성건위구풍약으로 소화불량, 토할 때, 위아픔 등에 사용된다.Baekdu ( Amomum cardamomum L.) is a evergreen perennial herb, whose fruit is used as a medicinal herb. The seeds of the fruit contain 2.4% of essential oils, and the main components of essential oils are d-bornone and d-campa, aromatic It is a dry stomach medicine used for indigestion, vomiting and stomach ache.
축사(Amomum xanthioides Wallich.)는 여러해살이풀로서, 씨에는 1.7-3%의 정유가 들어있으며, 정유에는 보르네올, 보르닐아세타트, 리날롤, 네롤리돌 등이 함유되어 있으며, 씨를 방향성건위약, 설사멎이약으로 사용하고 있다.Barn ( Amomum xanthioides Wallich.) Is a perennial herb, seed contains 1.7-3% essential oil, essential oil contains Borneol, bornylacetate, linalol, nerolidol, etc. , Diarrhea is used as a medicine.
백출은 삽주(Atractylodes japonica)의 뿌리를 일컫는 말로서, 삽주는 산지의 건조한 곳에서 자라는 국화과의 다년초이다. 삽주의 뿌리에는 약 1.5%의 정유, 카로틴, 이눌린, 고무질, 알칼로이드 등을 함유하고 있다. 소화관 및 피하조직에서 일어나는 수분대사(水分代謝)의 부전(不全)에 대하여 이뇨(利尿) ·발한(發汗) 작 용을 하며, 동통 ·위장염 ·부종에 효험이 있다. 민간에서는 혈압강하제로도 쓰인다.Eukchul refers to the root of the Atractylodes japonica , which is a perennial of the Asteraceae, which grows in dry places in the mountains. The root of the shovel contains about 1.5% essential oils, carotene, inulin, gum, and alkaloids. Diuresis, sweating, and dysfunction of water metabolism in the gastrointestinal tract and subcutaneous tissue are effective, and it is effective in pain, gastroenteritis and edema. It is also used as a blood pressure lowering agent in the private sector.
귤홍은 귤껍질의 안쪽에 있는 흰 부분을 벗겨 낸 껍질을 약재로 이르는 말이다.Tangerine red is a medicinal herb that peels off the white part of the tangerine peel.
인삼(Panax ginseng)은 쌍떡잎식물 산형화목 두릅나무과의 여러해살이풀로서, 깊은 산의 숲속에서 자라며 약용식물로 재배한다. 뿌리를 약용으로 사용하며 그 형태가 사람 형상이므로 인삼이라 하며, 배당체, 정유, 기름, 아미노산, 알칼로이드, 탄수화물, 수지, 미량원소 등이 함유되어 있다. 인삼은 예로부터 불로·장생·익기(益氣)·경신(輕身)의 명약으로 일컬어진다.Ginseng ( Panax ginseng ) is a perennial herb of the dicotyledonous hawthorn arboraceae , grows in deep mountain forests and grows as medicinal plants. The root is used for medicinal purposes and is called ginseng because it is a human form. It contains glycosides, essential oils, oils, amino acids, alkaloids, carbohydrates, resins and trace elements. Ginseng is said to be the old medicine of Buddha, Jangsaeng, Ikgi, and Shinshin.
침향(Aquilaria agallocha)은 쌍떡잎식물 도금양목 팥꽃나무과의 상록교목에 속하는 것으로서, 침향을 알칼리로 비누화한 다음 수증기증류를 하면 13%의 정유가 수득되며, 정유의 26%는 벤질아세톤, 53%는 p-메톡시벤질아세톤, 11%는 테르펜알콜로 되어 있다. 한방에서는 줄기를 약재로 사용하며, 진정·건위·통기 작용이 있으며 소화불량·식욕부진·구토·기관지천식 등에 효과가 있다. Aquilaria agallocha belongs to the evergreen arboreal of the dicotyledonous azaleas , which is 13% of essential oils obtained by saponifying with alkali and steam distillation. 26% of essential oils are benzyl acetone and 53% of p. -Methoxybenzyl acetone, 11% of terpene alcohol. In oriental medicine, the stem is used as a medicinal herb, and it has soothing, dry, breathing effects, and it is effective for indigestion, anorexia, vomiting, and bronchial asthma.
목향(Inula helenium)은 쌍떡잎식물 초롱꽃목 국화과의 여러해살이풀로서, 뿌리와 뿌리줄기에는 1-5%의 정유, 이눌린, 프세우도이눌린, 이눌레닌, 사포닌, 색소, 알칼로이드 등이 함유되어 있으며, 항염증작용, 혈압강하작용을 하며 정유는 방부작용, 항염증작용, 구충작용 등을 한다. Inula helenium is a perennial plant of the dicotyledonous plant, the Asteraceae, which contains 1-5% of essential oils, inulin, pseudoinulin, inulinen, saponin, pigments and alkaloids. Inflammation, blood pressure lowering action, essential oils are antiseptic, anti-inflammatory, hookworm action.
두충은 두충나무(Eucommia ulmoides Oliver)의 껍질을 의미하는 것으로서, 껍질에는 고무질과 유기산, 클로로겐산과 비타민 C, 적은량의 알칼로이드, 7%의 수 지, 2%의 쓴맛물질이 함유되어 있으며, 혈압강하작용이 강하다.Toothworm is the bark of Eucommia ulmoides Oliver, which contains rubbery and organic acids, chlorogenic acid and vitamin C, a small amount of alkaloids, 7% resin, and 2% bitter substances. This is strong.
후박나무(Machilus thunbergii)는 쌍떡잎식물 미나리아재비목 녹나무과의 상록교목으로서 나무껍질은 회황색이며 비늘처럼 떨어진다. 나무껍질과 잎을 분말로 하여 물로 적시면 점성이 강해지므로 선향(線香)의 결합제로 한다. 나무껍질을 염료로 사용하기도 한다. 한방에서는 나무껍질을 후박피(厚朴皮)라고 하며 천식과 위장병에 쓴다. Machilus thunbergii is an evergreen tree of the dicotyledonous plant of the genus Amphitaceae, and the bark is grayish yellow and scales like a scale. When the bark and leaves are powdered and wetted with water, the viscosity becomes stronger, so it is a binder of incense. Bark may also be used as a dye. In oriental medicine, the bark is called bakbakpi (厚朴 皮) and is used for asthma and stomach diseases.
생강(Zingiber officinale)은 외떡잎식물 생강목 생강과의 여러해살이풀로서, 뿌리줄기는 말려 갈아서 빵·과자·카레·소스·피클 등에 향신료로 사용하고, 껍질을 벗기고 끊인 후 시럽에 넣어 절이기도 하며 생강차와 생강주 등을 만들기도 한다. 한방에서는 뿌리줄기 말린 것을 건강(乾薑)이라는 약재로 쓰는데, 소화불량·구토·설사에 효과가 있고, 혈액 순환을 촉진하며, 항염증과 진통 효과가 있다.Ginger ( Zingiber officinale ) is a perennial herb of a monocotyledonous plant, Ginger tree, Ginger, which is dried and used as a spice in bread, cookies, curry, sauces, and pickles. And ginger wine. In oriental medicine, dried root stem is used as a health medicine, which is effective for indigestion, vomiting and diarrhea, promotes blood circulation, and has anti-inflammatory and analgesic effects.
정향(Eugenia aromaticum)은 쌍떡잎식물 도금양목 도금양과의 상록 소교목으로서, 정향은 매우 향기로우므로 그대로 또는 분말로 사용하고, 물이나 증기로 빼낸 정향유를 활용한다. 식품·약품·방부제 등에 쓰거나, 발작증을 비롯하여 치과에서 진통제 등으로 사용된다. 정향은 그 산출량이 적기 때문에 꽃봉오리뿐만 아니라 꽃대와 열매까지도 모두 이용하고 있다. Cloves ( Eugenia aromaticum ) is an evergreen small arborescent of dicotyledonous plated cranberry plated sheep. Cloves are very fragrant, so they are used as is or as powder, and clove oil extracted with water or steam is used. It is used in food, medicine, and preservatives, or as a painkiller in dentistry, including seizures. Cloves are low in yield, so they use not only buds but also flower beds and fruits.
강정제란 최음제라고도 하며, 남성의 음위 치료에 사용되는 약제로서 성욕, 성행위 능력의 강화를 기대하는 약물로 4가지 약제의 총칭이다. 첫째, 발기중추흥분제는 요힘빈, 스트리키닌 등이 있으는데, 흥분작용이 너무 강하여 신장장애를 일으킬 위험성이 있다. 둘째, 자극성 물질의 경우는 내복하면 소변으로 배출되는데, 그 때 요도를 자극하여 충혈을 일으키고, 또 지각신경을 자극하여 발기를 촉진한다. 휘발유, 수지, 칸다리딘 등이 있으며 이것들은 배설할 때 신장을 자극하여 신장염을 일으킬 위험이 있어 현재는 별로 사용되지 않는다. 셋째, 성호르몬 제제는 남성과 여성 호르몬의 화합물로 성기의 발육을 촉진하는 작용이 있는데, 잘못 사용하면 큰 해가 되므로 의사의 지시에 따라야 한다. 마지막으로 민간약으로 한방에서 유명한 팔미탕이 있다. 신체 냉통, 하복부 마비, 음위, 위축신, 전립선비대, 유뇨, 노쇠병에 사용된다. 또한 육미탕도 옛날부터 음위의 특효약으로 알려져 있다.Gangjeong, also known as aphrodisiac, is a drug used in the treatment of men's genitals and is expected to enhance sexual desire and sexual performance. First, erectile stimulants include yohimbine, strikinin, etc., the excitement is too strong, there is a risk of kidney failure. Second, in the case of irritant substance is discharged into the urine when the underwear, then stimulate the urethra to cause hyperemia, and stimulate the perceptual nerve to promote erection. There are gasoline, resins, and candaridine, and these are not currently used because they excrete the kidneys and cause a risk of nephritis. Third, sex hormone preparations are male and female hormone compounds that promote the development of the penis, and if used incorrectly will be a great harm, so you should follow your doctor's instructions. Lastly, there is Palmi-tang, which is famous for Chinese medicine. It is used for body cold, lower abdominal palsy, vulva, atrophy, prostate hypertrophy, urination, and senile disease. Yukmi-tang is also known as a potent medicine for the stomach.
강장제란 병약체를 개선하여 신진대사 기능을 회복하는 약제를 의미하는 것으로, 아비산제는 보혈강장제 변질제이고, 인 및 인산염은 인산 공여제, 키나제는 위액의 분비를 촉진하는 쓴맛의 강장제이다. 이러한 약제는 정상세포가 손상을 입지 않는 분량으로 병약세포를 파괴하여 그 흡수를 촉진한다. 자양강장제는 영양에 의해 기능회복을 꾀하는 것으로 각종 비타민제를 비롯하여 단백질제, 탄수화물, 미네랄, 필수아미노산 등이 있다.Tonic means a drug that improves the pathogen and restores metabolic function, arsenic acid is a blood tonic tonic denaturer, phosphorus and phosphate is a phosphate donor, and kinase is a bitter tonic that promotes secretion of gastric juice. These agents destroy the diseased cells in an amount that does not damage normal cells and promotes their absorption. Nutritious tonic is to restore the function by nutrition, including various vitamins, protein, carbohydrates, minerals, essential amino acids.
그러나 상기 강정제의 경우 약효보다는 부작용의 위험이 더 크기에 의사의 처방전없이 사용할 경우 위험할 수 있으며, 강장제 역시 과하게 복용할 경우 오히려 건강에 해를 끼치게 되는 문제점이 있다.However, in the case of the medicinal tablets, the risk of side effects is greater than the medicinal effects, so it may be dangerous if used without a doctor's prescription, and the tonic is also harmful to health if excessively taken.
글루타치온은 트리펩티드(γ-L-glutamyl-cysteinyl-glycine)의 비단백질성 티올(thiol) 화합물로, 간에서 만들어지는 아미노산의 일종으로 매우 강력한 항산화 물질이다. 세포내에서 산화형(GSSG)과 환원형(GSH)으로 존재하면서 세포벽의 보호와 세포증식, 아세타미노펜(acetaminophen)과 같은 독성물질의 해독 등 생체내에 서 중요한 생리활성을 나타내고 있다. 이와 같이 글루타치온은 생체내에서 여러가지 생리 및 대사에 관여하고 있기 때문에 부족하게 되면 용혈작용, 중추신경 작용의 영향, 용혈성 빈혈 및 백내장 등의 증상을 나타내기도 한다. 체내에서 글루타치온을 가장 많이 저장하고 있는 곳은 간이며 여러가지 음식을 통해서도 간에 저장된다. 따라서 현재는 글루타치온을 의학분야에서 간질환 치료제, 간기능 회복 및 해독작용 등의 질병치료에 널리 사용되고 있으며, 독성물질의 해독작용에 의한 생체내 산화를 억제시킴으로서 이와 관련한 각종 질환의 유발을 예방할 수 있다.Glutathione is a nonprotein thiol compound of tripeptide (γ-L-glutamyl-cysteinyl-glycine), a type of amino acid produced in the liver and is a very powerful antioxidant. It exists in oxidized form (GSSG) and reduced form (GSH) in cells, and shows important physiological activities in vivo, such as cell wall protection, cell proliferation, and detoxification of toxic substances such as acetaminophen. As such, glutathione is involved in various physiology and metabolism in vivo, and when it is deficient, hemolysis, central nervous system effects, hemolytic anemia and cataracts may be present. The most stored glutathione in the body is the liver, which is also stored in the liver through various foods. Therefore, glutathione is widely used in the medical field for the treatment of diseases such as liver disease treatment, liver function recovery and detoxification, and by inhibiting in vivo oxidation by detoxification of toxic substances, it is possible to prevent the occurrence of various related diseases. .
이에 따라 본 발명자들은 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향을 이용하여 약제로서보다는 일반 사람들의 접근이 용이한 술을 이용하여 사람들의 기호도와 함께 기능성을 갖춤과 동시에 술의 발효효모로서 글루타치온을 생성할 수 있는 사카로마이세스 세레비지애 FF-8 KACC 93023P를 사용함으로서 간을 보호할 수 있는 강장 또는 강정용 한방주인 본 발명을 완성하였다.Accordingly, the inventors of the present invention using the Angelica, Cheonggung, Banja, Baekjak, Astragalus, Broiler, Sukjihwang, licorice, Baekbokryeong, Baekdugu, Barn, Baekchul, Tangerine Hong, Ginseng, Incense, Mohyang, Tofu, Huyak, Ginger and Clove, rather than as a general medicine The saccharomyces cerevisiae FF-8 KACC 93023P, which can make glutathione as fermented yeast of alcohol, can be used by using liquor that is accessible to people, and at the same time, it can protect the liver. The present invention has been completed as a tonic or gangbang for herbal medicine.
본 발명의 목적은 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향을 글루타치온 생성능을 갖는 사카로마이세스 세레비지애(Saccharomyces cerevisiae) FF-8 KACC 93023P를 이용하여 발효시킨 강장 또는 강정용 한방주 및 이의 제조방법을 제공하는 것이다.An object of the present invention is sakura, cheonggung, hwangjak, baekryak, astragalus, broiler, sukjihwang, licorice, baekbokyeong, baekdugu, barn, baekchul, tangerine, ginseng, aroma, cedar, tofu, hindu, ginger and clove saccha having glutathione producing ability It is to provide a tonic or gangbang herbal wine fermented using Saccharomyces cerevisiae FF-8 KACC 93023P and a method for producing the same.
상기 목적을 달성하기 위하여, 본 발명은 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향의 한약재 추출액을 추출하는 제1단계;In order to achieve the above object, the present invention, Angelica, Cheonggung, Banja, Baekak, Astragalus, Broiler, Sukjihwang, Licorice, Baekbokryeong, Baekdugu, Barn, Baekchul, Tangerine Red, Ginseng, Incense, Mokyang, Tofu, Hubak, Ginger and Clove A first step of extracting the herbal medicine extract;
상기 한약재 추출액를 여과하는 제2단계;A second step of filtering the herbal medicine extract;
상기 제2단계에서 여과된 여과액을 사카로마이세스 세레비지애(Saccharomyces cerevisiae) FF-8 KACC 93023P를 접종하여 20-40℃에서 4-10일동안 1차 발효시키는 제3단계;A third step of inoculating the filtrate filtered in the second step with Saccharomyces cerevisiae FF-8 KACC 93023P and first fermenting at 20-40 ° C. for 4-10 days;
상기 제3단계의 발효후 여과하여 10-20℃에서 10-20일 동안 2차 발효시키는 제4단계;A fourth step of filtration after the fermentation of the third step and a second fermentation at 10-20 ° C. for 10-20 days;
상기 제4단계의 2차 발효액을 5-15℃에서 80-120일 동안 숙성시키는 제5단계;A fifth step of aging the second fermentation broth of the fourth step at 5-15 ° C. for 80-120 days;
상기 제5단계의 숙성시킨 후 50-80℃에서 저온 살균하는 제6단계로 구성된 강장 또는 강정용 한방주의 제조방법을 제공한다.After the aging of the fifth step provides a tonic or gangbang herbal wine manufacturing method consisting of a sixth step of pasteurization at 50-80 ℃.
상기 제1단계의 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향의 비율은 생약 건조 중량을 기준으로 4-5:4-5:2-3:4-5:2-3:2-3:4-5:2-3:4-5:2-3:2-3:4-5:4-5:4-5:2-3:2-3:4-5:2-3:2-3:1-2의 비율을 의미한다.The ratio of Angelica, Cheongung, Banja, Baekjak, Astragalus, Broiler, Sukjihwang, Licorice, Baekbokryeong, Baekdugu, Barn, Baekchul, Tangerine Hong, Ginseng, Aroma, Mokji, Tofu, Ghuak, Ginger and Clove of the first step is the dry weight of herbal medicine 4-5: 4-5: 2-3: 4-5: 2-3: 2-3: 4-5: 2-3: 4-5: 2-3: 2-3: 4-5 : 4-5: 4-5: 2-3: 2-3: 4-5: 2-3: 2-3: 1-2.
또한 상기의 제조방법에 의해 제조된 강장 또는 강정용 한방주를 제공한다.It also provides a tonic or steel herbal medicine prepared by the above manufacturing method.
이하, 본 발명을 한방주의 제조방법에 따라 상세히 설명한다.Hereinafter, the present invention will be described in detail according to the manufacturing method of herbal wine.
당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향의 한약재 추출액 추출하는 제1단계;The first step of extracting the herbal medicine extract of Angelica, Cheonggung, Banja, Baekjak, Astragalus, Broiler, Sukjihwang, Licorice, Baekbokyeong, Baekdugu, Barn, Baekchul, Tangerine, Ginseng, Aloe, Mokji, Tofu, Hubak, Ginger and Clove extract;
당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향 중에서 육계, 숙지황, 감초, 백복령, 축사, 백출 및 귤홍은 껍질을 벗겨서 사용하며, 침향, 목향 및 두충은 60-110℃, 바람직하게는 70-90℃에서 5-60분동안, 바람직하게는 5-20분동안 볶아서 사용하며, 후박은 잔뿌리를 제거하여 사용할 수 있다.Dongguk, Cheongung, Banja, Earl of Peony, Astragalus, Broiler, Sukjihwang, Licorice, Baekboknyeong, Baekdugu, Barn, Baekchul, Tangerine, Ginseng, Aloe, Mokji, Tofu, Huyak, Ginger, Clove and Clove Baekchul and tangerine are peeled and used, and aromas, throat and tofu are roasted at 60-110 ° C, preferably 70-90 ° C for 5-60 minutes, preferably 5-20 minutes. Can be used after removing.
상기에서 준비한 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향은 생약건조중량을 기준으로 4-5:4-5:2-3:4-5:2-3:2-3:4-5:2-3:4-5:2-3:2-3:4-5:4-5:4-5:2-3:2-3:4-5:2-3:2-3:1-2의 비율, 바람직하게는 5:5:2.5:5:2.5:2.5:5:2.5:5:2.5:2.5:5:5:5:2.5:2.5:5:2.5:2.5:1의 비율로 사용할 수 있다.Angelica, Cheongung, Banja, Baekjak, Astragalus, Broiler, Sukjihwang, Licorice, Baekbokryeong, Baekdugu, Barn, Baekchul, Tangerine Hong, Ginseng, Aloe, Mokheung, Tofu, Gakcho, Ginger and Clove prepared on the basis of the dry weight of herbal medicine -5: 4-5: 2-3: 4-5: 2-3: 2-3: 4-5: 2-3: 4-5: 2-3: 2-3: 4-5: 4-5 The ratio of: 4-5: 2-3: 2-3: 4-5: 2-3: 2-3: 1-2, preferably 5: 5: 2.5: 5: 2.5: 2.5: 5: 2.5: It can be used in a ratio of 5: 2.5: 2.5: 5: 5: 5: 2.5: 2.5: 5: 2.5: 2.5: 1.
상기의 비율로 준비한 한약재들의 추출액를 준비하기 위하여, 벌꿀 1-3ℓ, 바람직하게는 1.5-2.5ℓ 및 맥아당 3-6ℓ, 바람직하게는 3.5-4.5ℓ를 90-160℃, 바람직하게는 100-130℃에서 10-60분동안, 바람직하게는 30-40분동안 가열하고 가열하는 동안 발생하는 거품을 제거한 후 물 15-30ℓ, 바람직하게는 18-22ℓ를 첨가하고 상기의 비율로 혼합한 한약재를 첨가하여 90-160℃, 바람직하게는 100-130℃에서 30-120분동안, 바람직하게는 60-90분동안, 전체 13-18ℓ, 바람직하게는 14-16ℓ 가 될때 까지 가열하여 혼합 한약재의 추출액를 제조할 수 있다.In order to prepare the extract of herbal medicines prepared in the above ratio, 1-3-l honey, preferably 1.5-2.5 l and malt sugar 3-6 l, preferably 3.5-4.5 l, 90-160 ℃, preferably 100-130 ℃ Heat for 10-60 minutes, preferably 30-40 minutes, remove the bubbles generated during heating, add 15-30L of water, preferably 18-22L, and add the mixed herbal medicine An extract of the mixed herbal medicine is prepared by heating at 90-160 ° C., preferably 100-130 ° C., for 30-120 minutes, preferably 60-90 minutes, to a total of 13-18 L, preferably 14-16 L. Can be.
상기 한약재 추출액를 여과하는 제2단계;A second step of filtering the herbal medicine extract;
상기에서 준비한 혼합 한약재의 추출액를 20-50℃, 바람직하게는 30-40℃까지 냉각시킨 후 여과하여 혼합 한약재의 추출액 여과액을 준비할 수 있다.The extract of the mixed herbal medicine prepared above may be cooled to 20-50 ° C., preferably 30-40 ° C., and then filtered to prepare an extract of the mixed herbal medicine.
상기 제2단계에서 여과된 여과액을 사카로마이세스 세레비지애(Sacchromyces cerevisiae) FF-8 KACC 93023P를 접종하여 20-40℃에서 4-10일동안 1차 발효시키는 제3단계;A third step of inoculating the filtrate filtered in the second step with Sacchromyces cerevisiae FF-8 KACC 93023P and first fermenting at 20-40 ° C. for 4-10 days;
사카로마이세스 세레비지애 FF-8 KACC 93023P는 YM 배지에서 초기 pH 5-6, 바람직하게는 pH 6으로 조정하고, 온도는 20-40℃, 바람직하게는 25-35℃에서 교반속도는 80-120rpm, 바람직하게는 90-100rpm으로 하여 60-80시간동안, 바람직하게는 70-75시간동안 배양한다.Saccharomyces cerevisiae FF-8 KACC 93023P is adjusted to an initial pH of 5-6, preferably pH 6 in YM medium, the temperature is 20-40 ° C., preferably 25-35 ° C., the stirring speed is 80 Incubate at -120 rpm, preferably 90-100 rpm for 60-80 hours, preferably 70-75 hours.
상기 제2단계에서 제조한 혼합 한약재 추출액의 여과액에 상기에서 배양한 사카로마이세스 세레비지애 FF-8 KACC 93023P를 접종하고 20-40℃에서, 바람직하게는 30-35℃에서 4-10일동안, 바람직하게는 5-6일동안 호기성 발효를 시킨다.Inoculated with Saccharomyces cerevisiae FF-8 KACC 93023P cultured in the filtrate of the mixed medicinal herb extract prepared in the second step and 4-10 at 20-40 ℃, preferably 30-35 ℃ For days, preferably aerobic fermentation is carried out for 5-6 days.
상기 제3단계의 발효 후 여과하여 10-20℃에서 10-20일 동안 2차 발효시키는 제4단계;A fourth step of filtration after the fermentation of the third step and a second fermentation at 10-20 ° C. for 10-20 days;
상기 제3단계에서 발효된 액을 여과하여 10-20℃, 바람직하게는 13-15℃에서 10-20일동안, 바람직하게는 15-16일동안 2차 발효를 한다.The liquid fermented in the third step is filtered and subjected to secondary fermentation for 10-20 days, preferably 15-16 days, at 10-20 ° C, preferably 13-15 ° C.
상기 제4단계의 2차 발효액을 5-15℃에서 80-120일 동안 숙성시키는 제5단계;A fifth step of aging the second fermentation broth of the fourth step at 5-15 ° C. for 80-120 days;
상기 제4단계의 2차 발효액은 5-15℃, 바람직하게는 9-12℃에서 80-120일 동안, 바람직하게는 90-100일동안 숙성시킨다.The secondary fermentation broth of the fourth step is aged at 5-15 ° C., preferably at 9-12 ° C., for 80-120 days, preferably 90-100 days.
상기 제5단계의 숙성시킨 후 50-80℃에서 저온 살균하는 제6단계;A sixth step of pasteurization at 50-80 ° C. after aging of the fifth step;
상기 제5단계의 숙성된 후 50-80℃, 바람직하게는 60-70℃에서 저온살균하면 강장 또는 강정용 한방주가 제조된다.After aging in the fifth step, pasteurization at 50-80 ° C., preferably at 60-70 ° C., produces a tonic or steel herbal medicine.
상기의 방법으로 제조된 강장 또는 강정용 한방주의 알콜도수는 10-20도, 바람직하게는 13-15도의 알콜도수를 나타낸다.The alcohol content of the tonic or steel tablets prepared by the above method represents an alcohol content of 10-20 degrees, preferably 13-15 degrees.
이하, 본 발명의 하기의 실시예 및 실험예에 의하여 더욱 상세히 설명한다. 다만, 본 발명은 하기의 실시예 및 실험예에 의하여 본 발명의 범위가 한정되지는 않는다.Hereinafter, the following Examples and Experimental Examples of the present invention will be described in more detail. However, the present invention is not limited to the scope of the present invention by the following examples and experimental examples.
실시예 1. 한약재의 준비Example 1 Preparation of Herbal Medicine
당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향을 서울 경동시장에서 구입하여 육계, 숙지황, 감초, 백복령, 축사, 백출 및 귤홍은 껍질을 벗겨놓고, 침향, 목향 및 두충은 90℃에서 20분동안 볶아서 준비하고, 후박은 잔뿌리를 제거하여 준비하였다.Dongguk, Cheonggung, Banja, Baekjak, Hwanggi, Broiler, Sukjihwang, Licorice, Baekbokyeong, Baekdugu, Barn, Baekchul, Tangerine Hong, Ginseng, Aloe, Mokyang, Dougong, Hubak, Ginger and Clove from Seoul Gyeongdong Market. Licorice, baekbokyeong, barn, baekchul and tangerine were peeled off, and the aromas, throats, and tofu were roasted at 90 ° C. for 20 minutes, and bakbak was prepared by removing small roots.
실시예 2. 사카로마이세스 세레비지애 FF-8 KACC 93023P 배양Example 2 Saccharomyces cerevisiae FF-8 KACC 93023P Culture
사카로마이세스 세레비지애(Sacchromyces cerevisiae) FF-8 KACC 93023P는 YM배지(글루코스 1.0%, 펩톤 0.5%, 효모 추출액 0.3%, 맥아 추출액 0.3%)에서 초기 pH6으로 조정하고, 온도는 30℃에서 교반속도는 100rpm으로 하여 72시간동안 배양하였다.Sacchromyces cerevisiae FF-8 KACC 93023P YM medium (glucose 1.0%, peptone 0.5%, yeast extract 0.3%, malt extract 0.3%) was adjusted to initial pH6, the temperature was incubated for 72 hours at 30 ℃ stirring rate was 100rpm.
실시예 3. 강장 또는 강정용 한방주의 제조Example 3. Preparation of Tonic or Steel Tablets
벌꿀 2ℓ와 맥아당 4ℓ를 130℃에서 30분동안 가열하고 가열하는 동안 발생한 거품을 제거한 후 물 20ℓ를 첨가하고 상기 실시예 1에서 준비한 한약재를 당귀 100g, 천궁 100g, 반하 50g, 백작약 100g, 황기 50g, 육계 50g, 숙지황 100g, 감초 50g, 백복령 100g, 백두구 50g, 축사 50g, 백출 100g, 귤홍 100g, 인삼 100g, 침향 50g, 목향 50g, 두충 100g, 후박 50g, 생강 50g, 정향 20g을 첨가하여 전체 15ℓ정도가 될때까지 120℃에서 80분동안 가열하여 혼합 한약재의 추출액을 제조하였다.Honey 2 L and malt 4 L at 130 ° C. for 30 minutes, remove bubbles generated during heating, add 20 L of water, and add the herbal medicine prepared in Example 1 to Angelica 100g, Cheongung 100g, Half 50g, 100g of Baekjak, 50g, Broiler 50g, Sookjihwang 100g, Licorice 50g, Baekbokyeong 100g, Baekdugu 50g, Barn 50g, Baekchul 100g, Tangerine red 100g, Ginseng 100g, Aroma 50g, Mokjang 50g, Tofu 100g, Thick 50g, Ginger 50g, Clove 20g An extract of the mixed herbal medicines was prepared by heating at 120 ° C. for 80 minutes until it became.
상기 한약재 추출액은 30℃까지 냉각시킨 후 삼베를 이용하여 여과하였고, 상기 여과된 액은 깨끗한 독에 넣고 상기 실시예 2에서 배양한 사카로마이세스 세레비지애(Sacchromyces cerevisiae) FF-8 KACC 93023P를 접종하여 30℃에서 5일동안 1차적으로 호기성 발효를 수행하였다.The medicinal herb extract was cooled to 30 ° C. and then filtered using burlap. The filtered solution was placed in a clean poison and Sacchromyces cerevisiae FF-8 KACC 93023P cultured in Example 2 was used. Inoculation was performed primarily at aerobic fermentation for 5 days at 30 ℃.
상기에서 1차 발효된 액은 부드러운 헝겁을 이용하여 재여과하여 다시 다른 독으로 옮긴 후 13℃에서 15일동안 2차 발효를 수행하였다.The primary fermented liquor was refiltered using a soft cloth and transferred to another poison, followed by secondary fermentation at 13 ° C. for 15 days.
상기 2차 발효를 수행한 것을 새로운 용기에 담아 10℃에서 100일동안 숙성시킨 후, 60℃에서 저온살균하여 알콜도수가 15인 강장 또는 강정용 한방주를 제조하였다.The secondary fermentation was carried out in a new container and aged at 10 ° C. for 100 days, and then pasteurized at 60 ° C. to prepare a tonic or Gangjung herbal liquor having an alcohol content of 15.
실험예 1. 사카로마이세스 세레비지애 FF-8 KACC 93023P의 글루타치온 생성량Experimental Example 1. Glutathione production amount of Saccharomyces cerevisiae FF-8 KACC 93023P
상기 실시예 2에서 배양시킨 사카로마이세스 세레비지애 FF-8 KACC 93023P의 글루타치온 생성량을 분석하였다.Glutathione production of Saccharomyces cerevisiae FF-8 KACC 93023P cultured in Example 2 was analyzed.
오웬과 베체르의 방법을 응용하여(Owens, C.W.I. and Belcher, R.V., A colorimetric micro-method for the determination of glutathione. Biochem. J., 94, pp705-711, 1965),0.2M 인삼염 완충액(pH 7.1) 2.5㎖, 1.0mM EDTA 0.8㎖, 0.6mM DTNB 0.03㎖, 글루타치온 환원효소(5 unit)와 전처리한 시료 0.2㎖를 혼합한 후 412nm에서 흡광도를 측정하고 0.2mM NADPH 용액 0.1㎖를 첨가하여 30℃에서 5분동안 방치한 후 412nm에서 흡광도를 측정하였다. NADPH 용액첨가 전후의 흡광도 차이를 구하여 작성된 표준곡선으로부터 글루타치온 함량을 정량하였다.Applied by Owen and Becher (Owens, CWI and Belcher, RV, A colorimetric micro-method for the determination of glutathione. Biochem. J. , 94 , pp705-711, 1965), 0.2M ginseng buffer (pH 7.1) After mixing 2.5 ml, 1.0 mM EDTA 0.8 ml, 0.6 mM DTNB 0.03 ml, glutathione reductase (5 unit) and 0.2 ml of pretreated sample, absorbance was measured at 412 nm, and 0.1 ml of 0.2 mM NADPH solution was added. After standing at 5 ° C. for 5 minutes, the absorbance was measured at 412 nm. The glutathione content was quantified from the standard curve prepared by determining the difference in absorbance before and after adding NADPH solution.
상기 사카로마이에스 세레비지애 FF-8의 글루타치온의 양을 측정한 결과 글루타치온 생산량은 72.0㎎/ℓ임을 확인할 수 있었다.As a result of measuring the amount of glutathione of the Saccharomyces cerevisiae FF-8, it was confirmed that the glutathione production amount was 72.0 mg / L.
실험예 2. 관능검사Experimental Example 2. Sensory Test
2-1. 물리화학적 특성 및 후유증 검사2-1. Physical and chemical properties and sequelae test
상기 실시예 3에서 제조한 본 발명의 한방주와 일반 시판중인 한방주를 애머린(Amerine)의 포도주 관능검사법인 A-20 포인트카드법에 따라서, 맛 12점, 향 4 점, 외관(색도) 4점으로 하고 관능검사 대상인원을 20대 내지 60대 남성 50명으로 하여 관능검사를 실시하여 본 발명의 한방주의 물리화학적 특성을 실험하였으며, 또한 술을 마신 뒤의 후유증 검사를 실시하였으며, 검사결과의 평균값으로 기재하였다.According to the herbal wine of the present invention prepared in Example 3 and commercially available herbal wine according to A-20 point card method of Amerine (Amerine's wine sensory test), taste 12 points, flavor 4 points, appearance (color) A sensory test was performed with 4 points and 50 males in their 20s to 60s were tested for the physical and chemical properties of the herbal medicine of the present invention, and the sequelae test after drinking alcohol was performed. It was described as an average value of.
상기 실험 수행의 결과, 본 발명의 한방주의 물리화학적 특성이 시중에서 판매되는 일반 한방주에 비하여 회관, 향, 맛의 면에서 모두 탁월하였으며, 총점은 본 발명이 16.6으로 일반 한방주인 10에 비하여 현저히 탁월함을 확인할 수 있었다(표 1 참조). 또한, 술을 마신뒤의 후유증 여부에 대하여 검사한 결과, 일반 한방주가 두통, 속거부감, 복부 팽만감 및 숙취가 심한 경우가 각각 9, 23, 1, 6명으로 본 발명의 한방주는 심하다고 느낀 패널이 한명도 없은 것과 비교될 정도로 많았으며, 본 발명의 한방주를 마신 경우는 대부분의 패널이 모두 숙취 등 후유증이 거의 없음을 확인할 수 있었다(표 2 참조).As a result of the experiment, the physical and chemical properties of the herbal wine of the present invention were superior in terms of hall, aroma, and taste compared to general herbal wines sold in the market, and the total score of the present invention was 16.6. Excellence could be confirmed (see Table 1). In addition, as a result of testing after drinking alcohol as a result, the general herbal medicine is headache, snoring, abdominal bloating and severe hangover each 9, 23, 1, 6 patients, the panel of the present invention felt that the herbal medicine was severe There was a lot compared to not having one, and when drinking the herbal wine of the present invention, it was confirmed that most of the panels have almost no sequelae such as hangover (see Table 2).
2-2. 강장 또는 강정 효과 실험2-2. Tonic or elongation effect experiment
본 발명의 한방주의 강장 또는 강정 효과를 확인하기 위하여, 30대 내지 50대 남성 20명을 패널로 하여 본 발명의 한방주를 하루 1잔을 2달동안 시음하게 하고, 대조군으로서 일반적으로 강정에 효과가 있다고 알려진 창포주를 30대 내지 50대 남성 20명에서 하루 1잔을 2달동안 시음하게 함으로서 강장 또는 강정효과를 관찰하였다.In order to confirm the tonic or tonic effect of the herbal medicine of the present invention, 20 males in their 30s to 50s were used as a panel for tasting the herbal medicine of the present invention for 2 months a day, and as a control, it was generally effective for jeongjeong. Twenty males in their thirties to fifties who were known to have had a tonic or tonic effect by tasting one cup per day for two months.
그 결과, 하기 표 3에서 보는 바와 같이 일반적으로 강정에 효과가 있는 것으로 알려진 창포주의 경우 발기빈도수가 증가하였다는 패널은 7명, 성교 횟수가 증가하였다는 패널은 5명, 성교 만족도가 증가하였다는 패널은 8명에 불과하나, 본 발명의 한방주의 경우는 각각 15명, 14명, 16명으로서, 창포주에 비하여 2-3배의 효과가 탁월함을 확인할 수 있었다. 하기 표 3의 결과를 유추해 볼때 본 발명의 한방주는 신진대사 기능을 회복하여 체력을 증진시켜 주어 강장의 효과로 인하여 강정의 효과도 함께 나타나는 것으로 판단된다.As a result, as shown in Table 3 below, in the case of irises generally known to be effective in Gangjeong, seven panelists reported increased erectile frequency, five panelists reported increased number of sexual intercourse, and satisfaction with sexual intercourse increased. There are only eight panels, but in the case of herbal wines of the present invention, 15, 14, and 16 people, respectively, it was confirmed that the effect of 2-3 times as compared to the iris wine. Inferring the results of the following Table 3, the herbal medicine of the present invention is to restore the metabolic function to improve stamina to give the effect of Gangjeong due to the effect of tonic.
상술한 바와 같이, 본 발명은 당귀, 천궁, 반하, 백작약, 황기, 육계, 숙지황, 감초, 백복령, 백두구, 축사, 백출, 귤홍, 인삼, 침향, 목향, 두충, 후박, 생강 및 정향을 글루타치온 생성능을 갖고 있는 사카로마이세스 세레비지애(Saccharomyces cerevisiae) FF-8 KACC 93023P을 이용하여 발효시킨 강장 또는 강정용 한방주 및 이의 제조방법을 제공한다. 20가지 한약재를 원료로 하여 강장 또는 강정의 효과를 가지고 있으며, 또한 본 발명에서 사용한 효모인 사카로마이세스 세레비지애 FF-8 KACC 93023P은 간 질환의 예방에 많이 이용되는 효소인 글루타치온을 생성하므로 본 발명의 한방주 역시 간을 보호할 수 있는 효과를 갖는다. 따라서 본 발명의 한방주는 강장 또는 강정이라는 기능성과 함께 간을 보호할 수 있는 성분의 함유로 인한 건강주로서 소비자들의 기호도를 높일 수 있다.As described above, the present invention is glutathione-generating ability of Angelica, Cheonggung, Baekja, Baekjak, Astragalus, Broiler, Sukjihwang, Licorice, Baekbokryeong, Baekdugu, Barn, Baekchul, Tangerine Hong, Ginseng, Incense, Mokyang, Tofu, Huak, Ginger and Clove. It provides a tonic or gangjeong herbal wine fermented with Saccharomyces cerevisiae ( Saccharomyces cerevisiae ) FF-8 KACC 93023P and a method for producing the same. Since 20 kinds of herbal medicines are used as raw materials, they have the effect of tonic or gangjeong, and the yeast Saccharomyces cerevisiae FF-8 KACC 93023P used in the present invention produces glutathione, an enzyme that is used for the prevention of liver disease. The herbal wine of the present invention also has the effect of protecting the liver. Therefore, the herbal liquor of the present invention can increase the preference of consumers as a health liquor due to the content of ingredients that can protect the liver with the functionality of tonic or gangjeong.
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020050051776A KR100701336B1 (en) | 2005-06-16 | 2005-06-16 | Herb or alcohol for tonic or jeongjeong and its manufacturing method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020050051776A KR100701336B1 (en) | 2005-06-16 | 2005-06-16 | Herb or alcohol for tonic or jeongjeong and its manufacturing method |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20060131374A KR20060131374A (en) | 2006-12-20 |
KR100701336B1 true KR100701336B1 (en) | 2007-03-29 |
Family
ID=37811448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020050051776A Expired - Fee Related KR100701336B1 (en) | 2005-06-16 | 2005-06-16 | Herb or alcohol for tonic or jeongjeong and its manufacturing method |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR100701336B1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101178025B1 (en) | 2011-12-09 | 2012-08-29 | 하창현 | Tonic food |
CN103571704A (en) * | 2012-07-31 | 2014-02-12 | 苗丽荣 | Preparation method of agilawood health-care wine and agilawood wine thereof |
CN103740566A (en) * | 2013-12-27 | 2014-04-23 | 兴义市东泰天然果蔬开发有限公司 | Rosa roxbunghii medicinal liquor and preparation method thereof |
CN104673613A (en) * | 2015-03-31 | 2015-06-03 | 劲牌有限公司 | Health care wine for expelling wind-damp and enhancing immunity and preparation method thereof |
CN105623968A (en) * | 2016-04-05 | 2016-06-01 | 贵州省果树科学研究所 | Hylocereus polyrhizus mixed-fermentation fruit wine and brewage method thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110184159A (en) * | 2019-05-29 | 2019-08-30 | 吴世龙 | The method of one Yeasts compound and saccharomycete compound honey brewing wine |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS592680A (en) | 1982-06-28 | 1984-01-09 | Sapporo Breweries Ltd | Preparation of ratafia of ume (japanese apricot) |
JPS6012967A (en) | 1983-07-05 | 1985-01-23 | Taiyo Hakko Kk | Honey flower wine |
-
2005
- 2005-06-16 KR KR1020050051776A patent/KR100701336B1/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS592680A (en) | 1982-06-28 | 1984-01-09 | Sapporo Breweries Ltd | Preparation of ratafia of ume (japanese apricot) |
JPS6012967A (en) | 1983-07-05 | 1985-01-23 | Taiyo Hakko Kk | Honey flower wine |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101178025B1 (en) | 2011-12-09 | 2012-08-29 | 하창현 | Tonic food |
CN103571704A (en) * | 2012-07-31 | 2014-02-12 | 苗丽荣 | Preparation method of agilawood health-care wine and agilawood wine thereof |
CN103740566A (en) * | 2013-12-27 | 2014-04-23 | 兴义市东泰天然果蔬开发有限公司 | Rosa roxbunghii medicinal liquor and preparation method thereof |
CN104673613A (en) * | 2015-03-31 | 2015-06-03 | 劲牌有限公司 | Health care wine for expelling wind-damp and enhancing immunity and preparation method thereof |
CN105623968A (en) * | 2016-04-05 | 2016-06-01 | 贵州省果树科学研究所 | Hylocereus polyrhizus mixed-fermentation fruit wine and brewage method thereof |
Also Published As
Publication number | Publication date |
---|---|
KR20060131374A (en) | 2006-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101176590B1 (en) | Herbal Composition for Removing Hangover and Beverage Containing the Same | |
KR102136052B1 (en) | Composition for Liver Protection Containing Hub Extract and Beverage Thereof | |
KR101431417B1 (en) | The method of oriental composite for treatment of atopy and cancer | |
KR101663379B1 (en) | MANUFACTURE OF FERMENTED Allium hookeri FROM YEASTS AND NATURAL ENZYME AND PREPARATION OF COMBINED BEVERAGE FOR QUENCHING THIRST | |
CN110564570A (en) | agilawood-flavor liquor formula and method | |
KR100701336B1 (en) | Herb or alcohol for tonic or jeongjeong and its manufacturing method | |
CN106235318A (en) | The method preparing ferment for primary raw material with Flos Lonicerae, Rhizoma Curcumae Longae | |
KR100549286B1 (en) | Citron wine production method | |
CN106720727A (en) | A kind of trollflower herbal tea and preparation method thereof | |
KR20200114246A (en) | Manufacturing method of Overcooked Rice using Atractylodis Rhizoma Alba, Poria cocos Wolf, Astragali Radix, Malt and Massa Medicata Fermentata | |
CN104383412A (en) | Depression-resolving health traditional Chinese medicine liquor and preparation method thereof | |
KR100391819B1 (en) | A functional Doenjang preventing hypertension and kidney trouble and process for preparation thereof | |
KR101788253B1 (en) | Composition for improving male sexual function comprising the extract of Alpinia Officinarum, Smilacina Japonica & Black Garlic | |
CN105056096A (en) | Wine capable of tonifying kidney and promoting blood circulation to remove meridian obstruction, and preparation method thereof | |
KR102202852B1 (en) | Method for producing ssangwha tee and ssangwha tee produced by using same | |
KR20110080817A (en) | Health drink composition and preparation method thereof | |
CN103749839A (en) | Lucid ganoderma-pawpaw tea | |
CN106701410A (en) | Healthcare wine capable of strengthening stomach and tonifying qi and production method thereof | |
CN106805235A (en) | A kind of full nutrition formula food suitable for respiratory disease patient | |
CN106070783A (en) | A kind of production technology of Semen Coicis damp eliminating tea | |
KR102452902B1 (en) | Herbal medicinal liquor and its manufacturing method | |
CN107384680B (en) | Passion fruit and longan fruit wine and brewing method thereof | |
CN109908259A (en) | A kind of Phellinus drink and preparation method thereof for preventing, treating cancer | |
KR20100016684A (en) | Tea making method | |
KR20200007323A (en) | Manufacturing method for samgyetang using black ginseng and samgyetang using black ginseng manufactured by the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 20050616 |
|
PA0201 | Request for examination | ||
N231 | Notification of change of applicant | ||
PN2301 | Change of applicant |
Patent event date: 20060719 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
|
E902 | Notification of reason for refusal | ||
PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20060927 Patent event code: PE09021S01D |
|
PG1501 | Laying open of application | ||
E701 | Decision to grant or registration of patent right | ||
PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20070104 |
|
GRNT | Written decision to grant | ||
PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20070322 Patent event code: PR07011E01D |
|
PR1002 | Payment of registration fee |
Payment date: 20070323 End annual number: 3 Start annual number: 1 |
|
PG1601 | Publication of registration | ||
PR1001 | Payment of annual fee |
Payment date: 20100927 Start annual number: 4 End annual number: 4 |
|
FPAY | Annual fee payment |
Payment date: 20110323 Year of fee payment: 5 |
|
PR1001 | Payment of annual fee |
Payment date: 20110323 Start annual number: 5 End annual number: 5 |
|
LAPS | Lapse due to unpaid annual fee | ||
PC1903 | Unpaid annual fee |
Termination category: Default of registration fee Termination date: 20130209 |