CN109562087A - 软凝胶胶囊剂中β-羟基异戊酸制剂的稳定化 - Google Patents

软凝胶胶囊剂中β-羟基异戊酸制剂的稳定化 Download PDF

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Publication number
CN109562087A
CN109562087A CN201780031975.2A CN201780031975A CN109562087A CN 109562087 A CN109562087 A CN 109562087A CN 201780031975 A CN201780031975 A CN 201780031975A CN 109562087 A CN109562087 A CN 109562087A
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China
Prior art keywords
soft gel
gel capsule
capsule agent
liquid preparation
agent described
Prior art date
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Pending
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CN201780031975.2A
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English (en)
Chinese (zh)
Inventor
M·普尔普拉
R·耶格
J·顾
X·郑
Y·张
L·戴
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Jiyuan Group Co ltd
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TSI Group Ltd USA
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Application filed by TSI Group Ltd USA filed Critical TSI Group Ltd USA
Priority to CN202511046150.0A priority Critical patent/CN121177244A/zh
Publication of CN109562087A publication Critical patent/CN109562087A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201780031975.2A 2016-05-25 2017-05-25 软凝胶胶囊剂中β-羟基异戊酸制剂的稳定化 Pending CN109562087A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511046150.0A CN121177244A (zh) 2016-05-25 2017-05-25 包含3-羟基-3-甲基丁酸的软凝胶胶囊剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662341464P 2016-05-25 2016-05-25
US62/341,464 2016-05-25
PCT/US2017/034551 WO2017205673A1 (en) 2016-05-25 2017-05-25 Stabilization of beta-hydroxyisovaleric acid formulations in soft gel capsules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202511046150.0A Division CN121177244A (zh) 2016-05-25 2017-05-25 包含3-羟基-3-甲基丁酸的软凝胶胶囊剂

Publications (1)

Publication Number Publication Date
CN109562087A true CN109562087A (zh) 2019-04-02

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780031975.2A Pending CN109562087A (zh) 2016-05-25 2017-05-25 软凝胶胶囊剂中β-羟基异戊酸制剂的稳定化
CN202511046150.0A Pending CN121177244A (zh) 2016-05-25 2017-05-25 包含3-羟基-3-甲基丁酸的软凝胶胶囊剂

Family Applications After (1)

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CN202511046150.0A Pending CN121177244A (zh) 2016-05-25 2017-05-25 包含3-羟基-3-甲基丁酸的软凝胶胶囊剂

Country Status (12)

Country Link
US (3) US10959957B2 (enExample)
EP (1) EP3463327B1 (enExample)
JP (1) JP6929939B2 (enExample)
KR (1) KR102384266B1 (enExample)
CN (2) CN109562087A (enExample)
AU (1) AU2017270219B2 (enExample)
CA (1) CA3024584A1 (enExample)
CO (1) CO2018014085A2 (enExample)
MX (1) MX2018014407A (enExample)
MY (1) MY199597A (enExample)
RU (1) RU2018145520A (enExample)
WO (1) WO2017205673A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888325A (zh) * 2020-08-04 2020-11-06 瑞希(重庆)生物科技有限公司 一种卡拉胶凝胶、药物赋形剂和皮肤外用制剂

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7750505B2 (ja) * 2021-10-14 2025-10-07 中日本カプセル 株式会社 カプセル及びカプセルの製造方法

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US2870062A (en) * 1956-04-27 1959-01-20 Scherer Corp R P Gelatin composition for capsules
EP1105107B1 (en) * 1999-07-07 2006-11-15 R.P. Scherer Technologies, Inc. Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same
US20080031964A1 (en) * 2005-02-15 2008-02-07 Jallal Messadek Combination therapeutic compositions and method of use
CN101574146A (zh) * 2008-05-07 2009-11-11 北京康比特体育科技股份有限公司 一种含有hmb的运动营养补剂
WO2011075741A1 (en) * 2009-12-18 2011-06-23 Metabolic Technologies, Inc. Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb)
US20140080781A1 (en) * 2012-09-10 2014-03-20 Metabolic Technologies, Inc. Composition of HMB and ATP and Methods of Use
CN103889411A (zh) * 2011-07-15 2014-06-25 纽斯尔特科学公司 用于调节代谢途径的组合物和方法
WO2014152098A1 (en) * 2013-03-15 2014-09-25 Banner Pharmacaps Inc. Non-gelatin enteric soft capsules
WO2015094925A1 (en) * 2013-12-18 2015-06-25 Capsugel Belgium Nv Stable liquid filled hard capsule comprising beta-hydroxy-beta-methylbutyric acid

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US5200191A (en) 1991-09-11 1993-04-06 Banner Gelatin Products Corp. Softgel manufacturing process
US5569466A (en) 1995-05-17 1996-10-29 R. P. Scherer Corporation Fill compositions for soft elastic gel capsules
DE10064312C2 (de) 2000-12-22 2003-05-22 Degussa Cholinpyruvat-Hydrat, Verfahren zu dessen Herstellung, Cholinpyruvat-Hydrat enthaltende Formulierung sowie deren Verwendung
US7740878B2 (en) * 2001-10-22 2010-06-22 Danisco A/S Use of betaine to enhance exercise performance
EP1455763B1 (en) 2001-12-21 2007-10-03 Supernus Pharmaceuticals, Inc. Oral capsule formulation with increased physical stability
DE10208568A1 (de) 2002-02-27 2003-09-18 Degussa Bioactives Deutschland Verbindung, enthaltend Kreatin, eine Säure-Komponente und/oder einen Komplex-Bildner
DE10217557A1 (de) 2002-04-19 2003-11-06 Degussa Bioactives Gmbh Funktionsnahrungsmittel enthaltend eine Phospholipid-haltige stabile Matrix
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
US8231896B2 (en) * 2004-11-08 2012-07-31 R.P. Scherer Technologies, Llc Non-gelatin soft capsule system
DE102004060914A1 (de) 2004-12-17 2006-07-06 Bioghurt Biogarde Gmbh & Co. Kg Verwendung von Liponsäure-haltigen Cyclodextrin-Komplexen
DE102005061765A1 (de) 2005-05-19 2006-11-23 Degussa FreshTech Beverages LLC, Milwaukee Füllmaterial für einen Getränkebehälter
JP2009153529A (ja) 2009-04-17 2009-07-16 Tsujido Chemical Corp 食品組成物
CN103338658A (zh) 2010-12-22 2013-10-02 雅培制药有限公司 含有β-羟基-β甲基丁酸钙和共轭亚油酸的营养型产品
CN104918610B (zh) 2012-11-13 2018-04-10 纽斯尔特科学公司 用于增强能量代谢的组合物和方法
US20140272000A1 (en) 2013-03-14 2014-09-18 Metabolic Technologies, Inc. Liquids and Foodstuffs Containing beta-hydroxy-beta-methylbutyrate (HMB) in the Free Acid Form and Methods of Manufacturing or Producing the Same
HK1221609A1 (zh) 2013-05-01 2017-06-09 Abbott Laboratories 增强老化肌肉再生的方法
US20150366813A1 (en) * 2014-06-20 2015-12-24 Banner Life Sciences Llc Liquid-filled immediate release soft gelatin capsules
JP2018090504A (ja) * 2016-11-30 2018-06-14 株式会社東洋新薬 筋肉増強用組成物

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870062A (en) * 1956-04-27 1959-01-20 Scherer Corp R P Gelatin composition for capsules
EP1105107B1 (en) * 1999-07-07 2006-11-15 R.P. Scherer Technologies, Inc. Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same
US20080031964A1 (en) * 2005-02-15 2008-02-07 Jallal Messadek Combination therapeutic compositions and method of use
CN101574146A (zh) * 2008-05-07 2009-11-11 北京康比特体育科技股份有限公司 一种含有hmb的运动营养补剂
WO2011075741A1 (en) * 2009-12-18 2011-06-23 Metabolic Technologies, Inc. Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb)
CN103889411A (zh) * 2011-07-15 2014-06-25 纽斯尔特科学公司 用于调节代谢途径的组合物和方法
US20140080781A1 (en) * 2012-09-10 2014-03-20 Metabolic Technologies, Inc. Composition of HMB and ATP and Methods of Use
WO2014152098A1 (en) * 2013-03-15 2014-09-25 Banner Pharmacaps Inc. Non-gelatin enteric soft capsules
CN105263462A (zh) * 2013-03-15 2016-01-20 博纳生命科学有限公司 无明胶肠溶软胶囊
WO2015094925A1 (en) * 2013-12-18 2015-06-25 Capsugel Belgium Nv Stable liquid filled hard capsule comprising beta-hydroxy-beta-methylbutyric acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888325A (zh) * 2020-08-04 2020-11-06 瑞希(重庆)生物科技有限公司 一种卡拉胶凝胶、药物赋形剂和皮肤外用制剂

Also Published As

Publication number Publication date
EP3463327A1 (en) 2019-04-10
EP3463327A4 (en) 2020-01-22
WO2017205673A1 (en) 2017-11-30
KR20190021259A (ko) 2019-03-05
JP2019517576A (ja) 2019-06-24
CN121177244A (zh) 2025-12-23
RU2018145520A (ru) 2020-06-25
AU2017270219B2 (en) 2023-03-16
US12133920B2 (en) 2024-11-05
CO2018014085A2 (es) 2019-03-18
RU2018145520A3 (enExample) 2020-08-26
US20170340572A1 (en) 2017-11-30
KR102384266B1 (ko) 2022-04-06
BR112018073949A2 (pt) 2019-02-26
EP3463327B1 (en) 2024-04-17
BR112018073949A8 (pt) 2023-03-21
EP3463327C0 (en) 2024-04-17
AU2017270219A1 (en) 2018-11-29
MY199597A (en) 2023-11-08
US10959957B2 (en) 2021-03-30
CA3024584A1 (en) 2017-11-30
JP6929939B2 (ja) 2021-09-01
US20210212953A1 (en) 2021-07-15
US20250057773A1 (en) 2025-02-20
MX2018014407A (es) 2019-02-21

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