CN109550069A - 具有促愈合和皮肤抗炎功能的敷料及其制备方法 - Google Patents

具有促愈合和皮肤抗炎功能的敷料及其制备方法 Download PDF

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CN109550069A
CN109550069A CN201811635011.1A CN201811635011A CN109550069A CN 109550069 A CN109550069 A CN 109550069A CN 201811635011 A CN201811635011 A CN 201811635011A CN 109550069 A CN109550069 A CN 109550069A
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olibanum
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侯倩
付小兵
李美蓉
袁记方
陈德云
何文俊
仲苓芝
朱姿英
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Chinese PLA General Hospital
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Abstract

本发明涉及一种具有促愈合和皮肤抗炎功能的敷料包括仙鹤草、生藕节、乳香、蒲黄炭以及蚕丝蛋白,其中仙鹤草、生藕节、乳香、蒲黄炭的重量份均为0.5~500份。发明的目的是提供一种天然植物敷料,可以促进皮肤创伤的愈合,减轻炎症反应,性能稳定,安全无副作用。

Description

具有促愈合和皮肤抗炎功能的敷料及其制备方法
技术领域
本发明属于医药技术领域,涉及一种具有促愈合和皮肤抗炎功能的敷料及其制备方法。
背景技术
创伤早期的伤口愈合是一个多因素参与的复杂过程,组织渗液、炎性因子、各生长因子及微环境都参与创伤修复;针对创伤极早期以出血、渗液、易感染为特点,本研究将中药中的天然植物药组合物与敷料结合,实现创伤早期促愈合、抑制炎症。首先天然植物组合物为中药内服外用共用药物,现用于皮肤外用,具安全、色素沉着少、副作用小及清热解毒、抗感染疗效高等特点。现创伤早期植物药物干预的敷料较为少见,该发明为创面早期介入抗炎植物药治疗提供了可能。
发明内容
基于上述的技术问题,本发明的目的是提供一种天然植物敷料,可以抑制皮肤创伤感染的发生、发展,使皮肤较快愈合,性能稳定,安全无副作用,有可能为创面早期干预的植物药治疗填补空白。
本发明采用的技术方案是:
一种具有促愈合和皮肤抗感染功能的敷料,其特征在于:所述具有促愈合和皮肤抗炎功能的敷料包括仙鹤草、生藕节、乳香、蒲黄炭以及蚕丝蛋白液。
上述仙鹤草、生藕节、乳香、蒲黄炭的重量份为0.5~500份。
上述具有促愈合和皮肤抗炎功能的敷料的制备方法,包括以下步骤:
1)取一定重量份的仙鹤草、生藕节、乳香、蒲黄炭直接进行水煮,过滤,再进行氮吹,得到植物提取粉;或将仙鹤草、生藕节、乳香以及蒲黄炭经过55%-85%乙醇在常规密闭提取容器中提取,过滤,得到含有仙鹤草、生藕节、乳香、蒲黄炭的上清液;
2)将步骤1)得到的上清液与蚕丝蛋白液进行1:20混合;
3)将步骤2)得到的混合液,放置真空仪中干燥处理,即得到天然的片状海绵敷料。
上述蚕丝蛋白的质量浓度为5%。
本发明的技术特点是:本发明选择仙鹤草、生藕节、乳香、蒲黄炭的植物中药,具有止血、散瘀、凉血清热、消肿生肌、减轻炎症反应、不留瘢痕的功效,安全纯天然,可以很好的促进创伤愈合;同时选择蚕丝蛋白,将蚕丝蛋白的动物蛋白作用与植物纤维完美结合,并使植物纤维具有可塑形作用,成为敷料,促进肌肤的新陈代谢率,帮助修补受损的皮肤组织,共同实现促皮肤愈合。
附图说明
图1为本发明提供的蚕丝蛋白与不同比例时生成的敷料对比图。
具体实施方式
现结合附图以及实施例对本发明的具体实施做进一步的说明。
仙鹤草,性味苦、涩、平;功效收敛止血,截疟,止痢,清热解毒,补虚;主治用于咯血,吐血,崩漏下血,疟疾,血痢,痈肿疮毒,阴痒带下,脱力劳伤。
生藕节,甘涩、性平,既能收敛止血,又能散瘀血,具有止血不留瘀之特点,药力较缓,常作辅助止血药用。
乳香,性味辛、苦、温;具有活血行气止痛、消肿生肌的功效。
蒲黄炭,是一味化瘀止血的中药,味甘性平,能够止血同时不留瘀,中医上讲血见黑则止,所以止血药多会炒用,以增强止血功效。
蚕丝蛋白,天然蚕丝蛋白中的有效成份分层释放,10秒钟渗透肌肤真皮层,有效抑制黑色素生成,控制色素。促进胶原蛋白合成,活化细胞,提高细胞的免疫力,促进肌肤的新陈代谢率,从而控制炎症反应,帮助修补受损的皮肤组织,从而在较短时间内复原肌肤。作为动物蛋白可透过角质层与皮肤表皮细胞结合,并被细胞作为营养吸收,参与和促进细胞代谢,为其新陈代谢提供必需的养分,还能修复已损伤的皮肤,促进肌肤细胞修复的作用。
具有促愈合和皮肤抗炎功能的敷料包括仙鹤草、生藕节、乳香、蒲黄炭以及蚕丝蛋白。仙鹤草、生藕节、乳香、蒲黄炭的重量份为0.5~500份。仙鹤草、生藕节、乳香、蒲黄炭与蚕丝蛋白液的比例份数为0.1%-99%。
具有促愈合和皮肤再生功能的敷料的制备方法,包括以下步骤:
1)取一定重量份的仙鹤草、生藕节、乳香、蒲黄炭直接进行水提,过滤,再进行氮吹,得到植物提取粉;或将仙鹤草、生藕节、乳香、蒲黄炭经过55%-85%乙醇在常规密闭提取容器中提取,过滤,得到含有仙鹤草、生藕节、乳香、蒲黄炭的上清液;
2)将步骤1)得到的上清液制为冻干粉或步骤1)中的提取物与蚕丝蛋白液进行1:20混合;
3)将步骤2)得到的混合液,放置-20℃过夜,经真空仪干燥处理,即得到天然的片状海绵敷料。
实施例1
1)取不同重量份数的仙鹤草、生藕节、乳香、蒲黄炭配制成植物中药组合物,如下表所示:
按照上述实验1~实验23中所列的份数,取一定重量份的仙鹤草、生藕节、乳香、蒲黄炭直接进行水提取,过滤,再进行氮吹,得到植物提取粉;将提取粉与蚕丝蛋白液进行1:20混合;得到的混合液,在-20℃放置一夜,经真空仪干燥处理,即得到天然的片状海绵敷料。将实施例制成的23组天然敷料,随机用于23组、每组5人的烧伤患者处,每一种敷料对应治疗一组烧伤患者,敷料每天一次敷在伤患处,观察患处的创面,经过14天时间,患者的症状减轻、皮肤有明显的再生、表皮无痛苦,无瘙痒,炎症稀发。
实施例2
按照仙鹤草的重量份200份、生藕节的重量份155份、乳香的重量份210、蒲黄炭的重量份185配制组合物,将组合物在密闭容器中,经85%乙醇提取后,过滤,得到含有仙鹤草、生藕节、乳香、蒲黄炭的上清液与不同浓度的蚕丝蛋白液进行混合,其中,上清液的体积为50ml,蚕丝蛋白液的体积为1000ml,蚕丝蛋白液的浓度分别为1%、2%、5%、10%、20%;将得到的混合液,分别在-20℃放置一夜并经真空仪干燥处理,即得到五种天然的片状海绵敷料。
将五种敷料随机用于5组、每组5人的烧伤患者处,每一种敷料对应治疗一组烧伤患者,敷料每天一次敷在伤患处,观察患处的创面,经过14天时间,患者的症状明显减轻、皮肤有明显的再生、表皮无痛苦,无瘙痒,炎症少发。分析患者的症状变化可知当敷料中加入2%蚕丝蛋白时制成的敷料效果较好,安全经济。
实施例3
分别配置浓度为10%、20%、40%以及50%的含有仙鹤草、生藕节、乳香、蒲黄炭的混合液,取四组混合液50ml,并分别在中加入1000ml、2%的蚕丝蛋白液混合,将混合液在-20℃过夜并真空仪干燥后,得到四种海绵状的天然敷料;选择16位皮肤烧伤的患者,随机将患者分为四组,每组4人,四组患者对应地使用含仙鹤草、生藕节、乳香、蒲黄炭浓度为10%、20%、40%以及50%的四种敷料;每天一次敷在伤患处,观察伤患处的变化,经过7天时间,发现由2%的蚕丝蛋白与40%的ANBP溶液混合制成的敷料对伤口愈合以及皮肤的抗炎效果最佳,这是由于不同浓度比例制成的敷料其微观结构不同,参见图1,当选择2%的蚕丝蛋白与40%的ANBP溶液混合制得的敷料孔径较小,孔目较多,敷料与皮肤的接触面积大,吸附性强,药物作用面积广,炎症反应低。

Claims (6)

1.一种具有促愈合和皮肤抗炎功能的敷料,其特征在于:所述具有促愈合和皮肤抗炎功能的敷料包括仙鹤草、生藕节、乳香、蒲黄炭以及蚕丝蛋白;所述仙鹤草、生藕节、乳香、蒲黄炭的重量份均为0.5~500份。
2.如权利要求1所述的具有促愈合和皮肤抗炎功能的敷料的制备方法,其特征在于:所述制备方法包括以下步骤:
1)取一定重量份的仙鹤草、生藕节、乳香、蒲黄炭直接进行水提取,过滤,再进行氮吹,得到植物提取粉;
2)将步骤1)得到的植物提取粉与蚕丝蛋白液混合;
3)将步骤2)得到的混合液,置于-20℃中冷冻后,经真空干燥处理得成品。
3.根据权利要求2所述的具有促愈合和皮肤抗炎功能的敷料的制备方法,其特征在于:所述步骤2)中植物提取粉与蚕丝蛋白液的比例是1:20。
4.如权利要求1所述的具有促愈合和皮肤抗炎功能的敷料的制备方法,其特征在于:所述制备方法包括以下步骤:
1)取一定重量份的仙鹤草、生藕节、乳香、蒲黄炭经过乙醇在常规密闭提取容器中提取,过滤,得到含有仙鹤草、生藕节、乳香以及蒲黄炭的上清液;
2)将步骤1)得到的上清液与蚕丝蛋白液进行混合;
3)将步骤2)得到的混合液,置于-20℃中冷冻后,经真空干燥处理得成品。
5.根据权利要求4所述的具有促愈合和皮肤抗炎功能的敷料的制备方法,其特征在于:所述步骤2)中上清液与蚕丝蛋白的比例是1:20。
6.根据权利要求4或5所述的具有促愈合和皮肤抗炎功能的敷料的制备方法,其特征在于:所述乙醇的浓度是55%-85%。
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