CN1095373C - Medicine series for preventing and curing hypotension, angiocardiopathy and cerebrovascular disease and productive method thereof - Google Patents
Medicine series for preventing and curing hypotension, angiocardiopathy and cerebrovascular disease and productive method thereof Download PDFInfo
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- CN1095373C CN1095373C CN98108141A CN98108141A CN1095373C CN 1095373 C CN1095373 C CN 1095373C CN 98108141 A CN98108141 A CN 98108141A CN 98108141 A CN98108141 A CN 98108141A CN 1095373 C CN1095373 C CN 1095373C
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Abstract
The present invention relates to a medicine series for preventing and curing hypotension, and angiocarpy and cerebrovascular disease and a productive method thereof. The present invention is new medicine for preventing and curing hypotension, and angiocarpy and cerebrovascular disease, is prepared by that effective ingredients are extracted from spanishneedles herb plants, and belongs to the medicine field. The spanishneedles herb is processed with the productive technologies, such as cleanness, pulverization, immersion, decoction, extraction, filtering, concentration, spray-drying, etc., to be prepared into a medicament series having various preparations, such as injections, oral medicinal liquid, tablets, capsules, etc., a combination drug series which is prepared from the spanishneedles herb and other ingredients, and a created chemosynthesis, micro ecological benefit and gene medicine series. The present invention has the functions of preventing and curing hypotension, and angiocarpy and cerebrovascular disease, and has the advantages of obvious treating effect and no toxic or side effect.
Description
The present invention relates to a kind of medicament that is used to prevent and treat hypertension, cardiovascular and cerebrovascular disease, belong to medicine field.
Many weeks, hypertension, cardiovascular and cerebrovascular disease have become commonly encountered diseases and frequently-occurring disease, and also being that middle-aged and elderly people is modal disables and the cause of death.According to statistics, China has people up to a million every year approximately, and there is up to ten million people every year in the world approximately owing to hypertension, cardiovascular and cerebrovascular disease cause disabling, cause death, and hypertension, cardiovascular and cerebrovascular disease have now become the human maximum disease in the world.Influence along with various paathogenic factors, aging population constantly enlarges, hypertension, cardiovascular and cerebrovascular disease will become how much ladder situations to enlarge rapidly, existing now 1.2 hundred million people of hypertension, cardiovascular and cerebrovascular disease patient China, and annual newly-increased 1,600,000 people, human beings'health and life in serious threat.Threaten the human health and the hypertension of life, the brainstorm subject that cardiovascular and cerebrovascular disease has become the world medical circle maximum, hypertension, cardiovascular and cerebrovascular disease are in case captured, threaten human life's maximum disease can not exist, this will make the world human healthy and long-lived forever.But have direct instant effect at hypertension, cardiovascular and cerebrovascular disease now, effect is lasting, stable curative effect, remarkable, and cheap, the new drug that has no side effect is never succeeded in developing.
The purpose of this invention is to provide a kind of medicament that is used to prevent and treat hypertension, cardiovascular and cerebrovascular disease.Be the medicament of making by to Herba Bidentis Bipinnatae plant extract effective ingredient, have the effect of the hypertension of preventing and treating, cardiovascular and cerebrovascular disease, and direct instant effect, effect is lasting, and stable curative effect, significantly is cheap, and advantage such as have no side effect.
The Chinese medicine production craft step that elaboration prevents and treats hypertension, cardiovascular and cerebrovascular disease medicament is as follows;
1), Herba Bidentis Bipinnatae Herba Bidentis Bipinnatae (Bidens bipinnata L.) plant is cleaned.
2), the Herba Bidentis Bipinnatae after will cleaning is pulverized.
3), the Herba Bidentis Bipinnatae after will pulverizing adds a certain amount of purifying waste water and soaked 20-30 minute.
4), the Herba Bidentis Bipinnatae after will soaking decocts 30-40 minute (counting from boiling).
5), the solution after will decocting extracts filtration.
6), the solution after will filtering is through concentrating or drying is made Chinese medicine (liquid drugs injection; The powder pin).
7), will concentrate or exsiccant medicament becomes the injection finished product through packaged sterile.
Should in the purposes of Types of Medicine injection medicament have direct instant effect at hypertension, cardiovascular and cerebrovascular disease, effect is lasting, stable curative effect, significantly is cheap, advantage such as have no side effect.Can make hypertension, cardiovascular and cerebrovascular disease patient's blood pressure regulating reach normal range, play the effect of excellent prevention and treatment disease; This medicine can also improve cardiac function; Trinitroglycerin, beta Lipoprotein, cholesterol, blood viscosity all there are tangible reduction effect, prevent thrombosis effectively, prevent and treat cardiovascular and cerebrovascular diseases such as arteriosclerosis, cerebral thrombosis, coronary heart disease.
It is as follows that elaboration prevents and treats the little ecological medicament processing step of biotechnology of hypertension, cardiovascular and cerebrovascular disease:
1), Herba Bidentis Bipinnatae (Herba Bidentis Bipinnatae) pulverize is added in microorganism beneficial bacterium group lactobacillus with auxiliary facilitation, the Streptococcus lactis (Lister) Lohnis 1909.554..
2), with Herba Bidentis Bipinnatae according to the existing biotechnology catabolism that in fermentation tank, ferments.
3), with the purified oral liquid medicine of making of the solution behind the catabolism.
It is as follows that elaboration prevents and treats the biological gene medicine processing step of hypertension, cardiovascular and cerebrovascular disease:
1), on molecular level, effective genes of interest segment that the Herba Bidentis Bipinnatae plant has the hypertension of preventing and treating, cardiovascular and cerebrovascular disease is processed, separates, directionally obtained to the effective ingredient gene of selecting in its chromosome of Herba Bidentis Bipinnatae (Herba Bidentis Bipinnatae) plant to have the hypertension of preventing and treating, cardiovascular and cerebrovascular disease.
2), Herba Bidentis Bipinnatae is had effective genes of interest segment of the hypertension of preventing and treating, cardiovascular and cerebrovascular disease, external transfer to other can manually operated bio-carrier on, or the zooblast of antibacterial, yeast, artificial culture.Genes of interest segment and carrier are cut out with same restriction endonuclease, under the effect of ligase, both are linked up, realize reorganization.With transforming (being used for recombiant plasmid), transfection is transduceed (external phage packaging) then, and the recombinant vector that modes such as direct injection will be connected with genes of interest changes host cell over to, and recombinant molecule is selected, and selects the recombinant vector that can express fully.
3), the gene of Herba Bidentis Bipinnatae with effective ingredient of the hypertension of preventing and treating, cardiovascular and cerebrovascular disease can " program " in bio-carrier exactly, translate and express in large quantities.Produce have the hypertension of preventing and treating, the biological gene medicine of cardiovascular and cerebrovascular disease.
The characteristics that have the hypertension of preventing and treating, cardiovascular and cerebrovascular disease by Herba Bidentis Bipinnatae, the gene (in chromosome) in the Herba Bidentis Bipinnatae plant of Herba Bidentis Bipinnatae effective ingredient is separated, selected to obtain orientation with the technique for gene engineering means and prevent and treat the gene segment of hypertension, cardiovascular and cerebrovascular disease effective ingredient (obtaining needed genes of interest).On molecular level, bio-genetic material is processed, promptly cut off dna molecular with restricted enzyme; Under the effect of reverse transcriptase, obtain and the complementary dna single chain of messenger RNA sequence as template with messenger RNA, and then under the polymerase effect, be copied into double stranded rna molecule; With mechanical means such as ultrasound wave cut off dna molecular and make it for ease of the operation micromolecule; Obtain required gene (genes of interest) with methods such as chemical method synthetic.
Again the effective gene segment (genes of interest) that Herba Bidentis Bipinnatae is had the hypertension of preventing and treating, a cardiovascular and cerebrovascular disease external transfer to other can manually operated bio-carrier on (for example: the zooblast of antibacterial, yeast or artificial culture).Genes of interest and the carrier of choosing are cut out with same restriction endonuclease, under the effect of ligase, both are linked up, realize reorganization.Then with transforming (being used for recombiant plasmid), transfection, transduction (external phage packaging), the recombinant vector that modes such as direct injection will be connected with genes of interest changes host cell over to, and recombinant molecule is selected, and selects the carrier of the reorganization that can express.
The gene that Herba Bidentis Bipinnatae has the effective ingredient of the hypertension of preventing and treating, cardiovascular and cerebrovascular disease can " program " in bio-carrier exactly, makes the carrier of selecting reorganization obtain distinctive biological characteristic, carries out transcription and translation and expression in large quantities.Produce have the hypertension of preventing and treating, the bio-pharmaceutical of cardiovascular and cerebrovascular disease purposes, i.e. genetically engineered drug.
Dosage: come to amount according to taking dried person's 20 gram (add and purify waste water 1200 milliliters) the made medicaments of Herba Bidentis Bipinnatae plant every day.Dosage regimen: Chinese medicine (liquid drugs injection, powder pin) 2 times/day, 1 dose/time; Biological agent: 1～2 time/day.
Can obey Herba Bidentis Bipinnatae every day and do made dose, the purity that dosage regimen decides serial medicament and the quantity of taking medicine of person's 20 grams.
In sum, to be China prevent and treat the major progress that obtains aspect hypertension, the cardiovascular and cerebrovascular disease in vegetalitas in the present invention, for vast hypertension, cardiovascular and cerebrovascular disease patient provide a kind of new treatment weapon.Changed original releasing by limited medical treatment hypertension, cardiovascular and cerebrovascular disease and medicine and imitated slowly, it is not lasting to act on, and curative effect can not be stablized, and curative effect is not remarkable, costs an arm and a leg the history of toxic side effect.Empirical tests: the present invention has the effect of the hypertension of preventing and treating, cardiovascular and cerebrovascular disease, and direct instant effect, and effect is lasting, stable curative effect, remarkable, cheap, the advantage that has no side effect.
Claims (4)
1, a kind of injection that is used to prevent and treat the Chinese medicine purposes of hypertension, cardiovascular and cerebrovascular disease, it is characterized in that it is is the injection water injection that raw material is made according to conventional Chinese medicine technology with the Herba Bidentis Bipinnatae Herba Bidentis Bipinnatae, the purposes that is used to prevent and treat hypertension, cardiovascular and cerebrovascular disease.
2, according to the described a kind of injection that is used to prevent and treat the Chinese medicine purposes of hypertension, cardiovascular and cerebrovascular disease of claim 1, it is characterized in that and it can be made injectable powder, be used to prevent and treat the purposes of hypertension, cardiovascular and cerebrovascular disease.
3, a kind of microbial ecological agent that is used to prevent and treat hypertension, cardiovascular and cerebrovascular disease according to claim 2, it is characterized in that it with the Herba Bidentis Bipinnatae Herba Bidentis Bipinnatae be raw material according to existing little ecological technique in fermentation tank, be aided with the microorganism lactobacillus, Streptococcus lactis (Lister) Lohnis 1909.554. makes through fermentation catabolism, purification.
4, a kind of gene formulations that is used to prevent and treat hypertension, cardiovascular and cerebrovascular disease according to claim 3, it is characterized in that it is is genes of interest according to selecting to have the gene segment that can prevent and treat hypertension, cardiovascular and cerebrovascular disease in the Herba Bidentis Bipinnatae Herba Bidentis Bipinnatae chromosome, be transferred to bio-carrier according to existing technique for gene engineering, reorganization, express, make the gene formulations that forms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98108141A CN1095373C (en) | 1997-03-27 | 1998-03-19 | Medicine series for preventing and curing hypotension, angiocardiopathy and cerebrovascular disease and productive method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97101479 | 1997-03-27 | ||
| CN97101479.5 | 1997-03-27 | ||
| CN98108141A CN1095373C (en) | 1997-03-27 | 1998-03-19 | Medicine series for preventing and curing hypotension, angiocardiopathy and cerebrovascular disease and productive method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1198342A CN1198342A (en) | 1998-11-11 |
| CN1095373C true CN1095373C (en) | 2002-12-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98108141A Expired - Fee Related CN1095373C (en) | 1997-03-27 | 1998-03-19 | Medicine series for preventing and curing hypotension, angiocardiopathy and cerebrovascular disease and productive method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100353944C (en) * | 2004-06-24 | 2007-12-12 | 杨立新 | Urapidil large volume injection, its preparation method and application |
| CN101396495B (en) * | 2007-09-26 | 2011-03-30 | 王玉朝 | Traditional Chinese medicine for treating cardiovascular and cerebrovascular disease |
| CN101849997B (en) * | 2010-06-21 | 2012-06-20 | 南京中医药大学 | Traditional Chinese medicine composition capable of reducing blood pressure and tonifying kidney and preparation method and application thereof |
| CN102727530A (en) * | 2012-04-30 | 2012-10-17 | 威海康博尔生物药业有限公司 | Combination and application of probiotics and related prebiotics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1051300A (en) * | 1989-10-28 | 1991-05-15 | 李庆东 | A kind of method that Herba Bidentis Bipinnatae is manufactured oral liquid |
| CN1078120A (en) * | 1992-05-07 | 1993-11-10 | 李庆东 | A kind of method of making health instant powder of Herba Bidentis Bipinnatae |
-
1998
- 1998-03-19 CN CN98108141A patent/CN1095373C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1051300A (en) * | 1989-10-28 | 1991-05-15 | 李庆东 | A kind of method that Herba Bidentis Bipinnatae is manufactured oral liquid |
| CN1078120A (en) * | 1992-05-07 | 1993-11-10 | 李庆东 | A kind of method of making health instant powder of Herba Bidentis Bipinnatae |
Non-Patent Citations (1)
| Title |
|---|
| 《中西结合杂志》1989,9(1) 1989.2.1 李庆东，"鬼针草抗实验性高血及血栓形成的作用" * |
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| Publication number | Publication date |
|---|---|
| CN1198342A (en) | 1998-11-11 |
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