CN109528985A - It is a kind of for treating the Chinese materia medica preparation and preparation method of fibroid and lobular hyperplasia - Google Patents
It is a kind of for treating the Chinese materia medica preparation and preparation method of fibroid and lobular hyperplasia Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of for treating the Chinese materia medica preparation of fibroid and lobular hyperplasia, it is to belong to Chinese medicine invention field using olibanum, myrrh, ground beetle, rhizoma cyperi, Fructus Liquidambaris, honeycomb, mountain rib, curcuma zedoary, Radix Aconiti, saltcake, leech as raw material.According to the different characteristics of every taste Chinese medicine, after cleaning stripping and slicing pretreatment, prepares, made through specific process in proportion, have the function of promoting qi circulation and removing obstruction in the collateral, dispelling stasis of blood and stimulating the menstrual flow, antalgic, promoting blood circulation dehumidifying, product of the present invention combination and production method are unique, and according to clinical verification, the medicine therapeutic effect is significant, treatment cycle is short, it is cheap, it has no adverse reaction and any toxic side effect, has a vast market application prospect.
Description
Technical field
The present invention relates to a kind of Chinese materia medica preparations, and in particular to a kind of for treating the Chinese medicine system of fibroid and lobular hyperplasia
Agent, the invention further relates to the preparation methods of the Chinese materia medica preparation.
Background technique
Fibroid be in female sex organ in one of the most common type benign tumour and human body the most common tumour it
One, also known as fibromyoma, fibroid.Since fibroid is mainly formed by Uterine Smooth Cell hyperplasia；Leaflet increases
Sick change is the pathologic process based on body of gland leaflet and the expansion of breast duct tip, hyperplasia and Cystic changes.Its generation and
Development is related with Function of Ovary disorder, mostly since Progesterone Secretion deficiency and estrogen are opposite or absolutely excessive, causes
The hyperplasia of breast tissue and restoration of old ways process get muddled and fall ill in menstrual cycle.
The reason of traditional Chinese medicine thinks, causes the proliferation of mammary gland or mammary gland fibroma is stagnation of QI due to depression of the liver and disharmony of Chong and Conception Channels, is needed
Soothing liver-qi stagnation adjusts punching and appoints.
Currently, fibroid and lobular hyperplasia there is no specific short.Mifepristone, tamoxifen (tamoxifen), rush property
Glandular hormone releasing hormone agonist (GnRH-a) etc. has certain curative effect.But the long-term or short time is treated using these drugs,
It can cause obesity, crinosity, acne, hypertension, oedema, Nausea and vomiting, dizziness etc. a series of side effects symptom, and to hormone
The dependence produced, primary affection knock-on aggravates to control with secondary side effect, the pain that patient's generation can be made very big after drug withdrawal
Again and again, effect is unobvious for treatment process, costly etc., causes biggish pressure at heart and ailing pressure to patient.
Summary of the invention
The purpose of the present invention is to provide a kind of for treating the Chinese materia medica preparation of fibroid and lobular hyperplasia, the Chinese medicine system
Agent has therapeutic effect significant treatment fibroid and lobular hyperplasia, and healing time is short, cheap, have no adverse reaction and
The characteristics of secondary toxic action.
Inventor is in the clinical treatment practice of many years, according to the rule of development of the illness and the combination principle of Chinese medicine,
And by a large amount of clinical verification, Exploration and conclusion goes out to be used to treat newly matching for the Chinese materia medica preparation of fibroid and lobular hyperplasia repeatedly
Side.The characteristics of present invention has therapeutic effect significant, and healing time is short, cheap, has no adverse reaction with secondary toxic action.
The effect of drug in the present invention:
Wherein:
Olibanum: for Burseraceae Boswellia carterii platymiscium Boswellia carterii Boswellia carterii Birdw. [B. sacra
Fluek.], medicine glue perfume (or spice) tree B. bhawdajiana Birdw. and open country Boswellia carterii B. neglecta M. Moore etc., trunk
The oleo-gum-resin of skin zone's wound exudation.Nature and flavor: pungent, bitter, temperature.Effect: promoting blood circulation and stopping pain.For all pains of trusted subordinate, muscle arteries and veins contraction, bruise
Damage, sore, carbuncle and painful swelling；Externally used detumescence myogenic.Record in " detailed outline ": " all poison of the ulcer that disappears, Tuoli shield heart, analgesic therapy of invigorating blood circulation, stretch muscle, control
Married woman's difficult labour, injured.
Myrrh: for Burseraceae myrrh platymiscium myrrh Commiphora myrrha Engl. [C. molmol Engl.]
And it belongs to him and plants the oleo-gum-resin of the trunk skin zone exudation of plant.Nature and flavor: it is bitter, it is pungent, it puts down.Returns spleen, kidney, liver, the heart channel of Hang-Shaoyin.Effect: it dissipates
Blood stasis eliminatings, detumescence ding-tong.Cure mainly chest and abdomen stasis caused pain, dysmenorrhea, menostasis, abdominal mass, traumatic injury, carbuncle swells sore, acute appendicitis, red eye, swell pain.
There are promoting blood circulation and stopping pain, detumescence and promoting granulation and other effects.
Ground beetle: for Corydiidae eupolyphagasinensis walker Eupolyphaga sinensis Walker or polyphagaplancyi
Steleophaga plancyi(Boleny) female adult hirudo leech.Nature and flavor: it is salty, it trembles with fear；It is slightly poisonous.Return liver warp.Effect: broken stasis of blood blood,
Continuous muscles and bones.For injured bone, blood stasis closed, abdominal mass lump in the abdomen.
Rhizoma cyperi: for the dry rhizome of sedge nutgrass flatsedge Cyperus rotundus L..Nature and flavor: pungent, slight bitter, micro-
Sweet and neutral.Return liver, spleen, tri-jiao channel.Effect: promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, digestion
It is bad, chest gastral cavity ruffian, cold hernia stomachache, swollen breasts, irregular menstruation, amenorrhea and algomenorrhea.It is recorded in " detailed outline ": the cold epidemic disease of gas, benefit when dissipating
Three is burnt, Xie Liuyu, and the diet that disappears accumulation, phlegm retention feeling of fullness, instep is swollen, abdominal distension, tinea pedis, only trusted subordinate, limbs, head, mesh, tooth, all pains of ear, carbuncle
Subcutaneous ulcer sore is spitted blood, lower blood, hematuria, married woman's metrorrhagia and metrostaxis leukorrhagia, waits uncomfortable, postpartum all kinds of diseases and ailments before tire by the moon.
Fructus Liquidambaris: for the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum Liquidambar formosana Hance.
Nature and flavor: it is bitter, it puts down.Return liver and kidney channel.Effect: dispelling, collateral-activating, Li Shui stimulates the menstrual flow.For arthralgia, numbness contracture, edema swelling, cream
Few menostasis.It is recorded in " detailed outline is picked up any lost article from the road ": warding off miasma but pest, improving eyesight, dehumidifying, relaxing muscles and tendons network muscular constricture, whole body numbness pain, trick and pain in the loins, burn
Its flue gas of smelling all be cured.
Honeycomb: for Vespidae insect hornet or the nest of nearly edge insect is belonged to.Nature and flavor: sweet and neutral, it is toxic.Return liver, lung channel.
Effect: poison, desinsection are attacked in wind-dispelling.Control frightened epilepsy, wandering arthritis, urticaria itch, acute mastitis, serious case of furuncle, scrofula, anal fistula, acute toothache, favus of the scalp, bee
Sting swollen pain.It is recorded in Shennong's Herbal: main frightened epilepsy Chi Zong, fever and chills perverse trend, insane disease, perianal abscess.
Mountain rib: also known as trigone, it is Sparganiaceae plant rhizoma scirpi Sparganium stoloniferum Buch.-Ham.
Dry tuber.Nature and flavor: it is pungent, bitter, it puts down.Return liver, the spleen channel.Effect: breaking blood and promoting the circulation of qi, clearing stagnation and killing pain.For abdominal mass lump in the abdomen, hemostasis warp
It closes, dyspepsia distending pain.It records in " Japan hanako materia medica ": controlling that married woman's blood vessels are uncomfortable, and pain in the chest and abdomen falls tire, disappear extravesated blood, mends labor, lead to menstruation,
Control inflatable, disappear and flutter damage hemostasis, postpartum abdominal pain, blood fortune and place blood not under.
Curcuma zedoary: for zingiberaceous plant zedoary Curcuma phaeocaulis Val., Guangxi zedoary Curcuma
Kwangsiensis S. G.Lee et C. F. Liang or RADIX CURCUMAE Curcuma wenyujin Y.H. Chen et C.
The dry rhizome of Ling.Nature and flavor: pungent, bitter, temperature.Return liver, the spleen channel.Effect: promoting the circulation of qi blood-breaking, clearing stagnation and killing pain.For Dan lump in the abdomen lump in the abdomen, the stasis of blood
Blood menostasis, dyspepsia distending pain；Early cervical carcinoma.
Radix Aconiti: for dry female root of ranunculaceae plant rhizome of Chinese monkshood Aconitum carmichaelii Debx..Nature and flavor: pungent,
Hardship, heat；It is very toxic.Return heart, liver,kidney,spleen warp.Cure mainly dispelling wind and eliminating dampness, antalgic.It is used for treating arthralgia due to cold and dampness, arthralgia, trusted subordinate
Crymodynia, cold hernia is had a pain and narcotic analgesic.
Saltcake: being mineral saltcake through refining crystallization obtained by boiling-off.Nature and flavor: working hard salty, trembles with fear.Return stomach, large intestine channel.Effect:
It purges heat, moisturizes, softening hard masses.It is stagnant to control real heat, abdominal distention constipation stops phlegm accumulation, and mouth is red to hide from view, erysipelas, carbuncle swells.Note in " book on Chinese herbal medicine is new again "
Carry: it is damp and hot to wash three burnt stomach, weeding through the old to new, typhoid fever fulminant dysentery, and accumulation knot addiction is stopped phlegm leaching and closed, and scrofula sore swells, hot eyes is hidden from view, promoting menstruation
Induced abortion.
Leech: for Hirudinidae animal whitmania Whitmania pigra Whitman, leech Hirudo nipponica
The hirudo leech of Whitman or willow leaf leech Whit-mania acranulata Whitman.Nature and flavor: it is salty, bitter, it puts down；It is slightly poisonous.
Return liver warp.Effect: blood-breaking, by the stasis of blood, promoting menstruation.For abdominal mass lump in the abdomen, blood stasis, injury from falling down.
Square solution of the invention is: myrrh dissipates blood stasis eliminatings, detumescence ding-tong, ground beetle blood stasis closed, abdominal mass lump in the abdomen, rhizoma cyperi promoting the circulation of qi
Relieve stagnation, menstruction regulating and pain relieving, leech dispelling stasis of blood and stimulating the menstrual flow, the above four traditional Chinese medicine have promoting qi circulation and removing obstruction in the collateral, by the stasis of blood as monarch drug in a prescription in side, equal return liver warp
The effect of promoting menstruation.Traditional Chinese medicine thinks that Chinese medicine thinks, fibroid and lobular hyperplasia pathogenic factor are because healthy energy is insufficient or exopathogen
Invasion, inside there is seven feelings, chamber diet, and then leads to internal organs dysfunction, qi-blood disharmony, mechanism of qi retardance, so that extravasated blood is exercised, it is wet
Turbid product is caused in the positions such as underbelly or mammary gland without dissipating.The people of the liver and spleen of lesion internal organs duty, especially spleen soil weakness or overfeeding
Pungent delicious food savoury, damage spleen soil, and cause spleen soil transportation capabilities not normal, gathering wet is phlegm or cause liver dysfunction, and Yu Ercheng phlegm etc. is led
Cause phlegm wet knot poly-, qi and blood stagnation and form lump.So promoting qi circulation and removing obstruction in the collateral, dispelling stasis of blood and stimulating the menstrual flow are treatment fibroid and lobular hyperplasia
Basis, the above four traditional Chinese medicine are monarch drug in a prescription, fundamentally carry out promoting qi circulation and removing obstruction in the collateral, dispelling stasis of blood and stimulating the menstrual flow to disease in claim 1 first, make
Illness obtains basic control.Olibanum promoting blood circulation and stopping pain, Fructus Liquidambaris dispelling, collateral-activating, Li Shui stimulates the menstrual flow, mountain rib breaking blood and promoting the circulation of qi, disperse accumulation are stopped
Bitterly, curcuma zedoary promoting the circulation of qi blood-breaking, clearing stagnation and killing pain, Radix Aconiti dispelling wind and eliminating dampness, antalgic, the above five kinds of Chinese medicine are ministerial drug in side, pass through tune
Reason liver and spleen kidney punching appoints uterus function to reach vegetative nerve function, reproductive endocrine system and the immune function for adjusting disorder, thus
Dual regulation is played to women neuroendocrine-immune system.On the one hand the function of monarch drug in a prescription promoting qi circulation and removing obstruction in the collateral, dispelling stasis of blood and stimulating the menstrual flow is assisted
Effect；On the other hand have effects that antalgic, promoting blood circulation dehumidifying as ministerial drug.Poison is attacked in honeycomb wind-dispelling, and saltcake softening mass and moistening dryness is above
Two taste medicines cause the inducement of fibroid and lobular hyperplasia as adjutant, from pathologically treatment, can promote the monarch and his subjects as adjutant
The effect of promotings qi circulation and removings obstruction in the collateral of two medicines, dispelling stasis of blood and stimulating the menstrual flow, but can two medicine of using corrigent the monarch and his subjects promote the work of body antalgic, promoting blood circulation dehumidifying
With.Being used as simultaneously has effects that wind-dispelling is moisturized.This side's all medicines share, the monarch and his subjects pull together, minister assistant altogether it is auxiliary, have promoting qi circulation and removing obstruction in the collateral, by
The effect of stasis of blood promoting menstruation, antalgic, promoting blood circulation dehumidifying, it can effectively treat fibroid and lobular hyperplasia.
Medicine material dosage of the present invention is to carry out largely groping to summarize to obtain through inventor, and each raw material dosage is following
Parts by weight range all has having a better effect: olibanum 50-70g, myrrh 50-70g, ground beetle 50-70g, rhizoma cyperi 60-80g, Lu Lu
Logical 50-70g, honeycomb 60-80g, mountain rib 50-70g, curcuma zedoary 50-70g, Radix Aconiti 30-50g, saltcake 150-170g, leech 50-
70g。
Wherein preferably are as follows: olibanum 60g, myrrh 60g, ground beetle 60g, rhizoma cyperi 70g, Fructus Liquidambaris 60g, honeycomb 70g, mountain rib
60g, curcuma zedoary 60g, Radix Aconiti 40g, saltcake 160g, leech 60g.
An important feature of the invention is nutrition rich in and vitamin in Chinese materia medica preparation, wherein dimension life
The content of plain B, C are 0.1%-0.3%, and considerably beyond the content of vitamin in vegetable and fruit, vitamin B, C can alleviate spiritual pressure
Power is big, fatiguability, stress, is conducive to the recovery of the patient of fibroid and lobular hyperplasia, and egg in Chinese medicine preparation
White matter and the content of cellulose are also very much, and patient's constitution can be enhanced in protein, cellulose, accelerate the recovery of patient.
The present invention is Chinese materia medica preparation nutritional ingredient rich in there are also another important feature, has 17 rich in amino acid
Kind or more, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylpropyl alcohol
Propylhomoserin has iron, chromium, copper, boron, manganese, strontium and zinc containing the essential trace elements of the human body, and several human bodies of another calcic, potassium, magnesium, phosphorus are macro
Secondary element.The above nutritional ingredient is all substance needed by human, can effectively be enhanced human immunity.
It is a kind of for treat the Chinese materia medica preparation of fibroid and lobular hyperplasia the preparation method is as follows:
Step 1: pressing weight of the present invention, takes olibanum, and myrrh, saltcake cross 200 meshes, spare；
Step 2: pressing weight of the present invention, ground beetle, honeycomb, Radix Aconiti, leech medicinal material taken to be placed in casserole, is added 3 times
The water of volume intense fire infusion 20-30 minutes, turns mild fire infusion 30-40 minutes, filter liquor, and infusion three times, merges three times repeatedly
Filtrate is spare；
Step 3: weight proportion of the present invention is pressed, takes curcuma zedoary, mountain rib, Fructus Liquidambaris, rhizoma cyperi medicinal material to be placed in casserole, 3 times of volumes is added
Water, after intense fire infusion 20-30 minutes, addition turn mild fire infusion 30 ~ 40 minutes filtrate, repeatedly infusion merges three times gained filter
Liquid, it is spare；
Step 4: merge Step 2: step 3 obtained by filtrate and with step 1 obtained by powder, mixing, stir evenly, by medicine soup carry out it is dense
75 ° of alcohol are added according to 20:1 ratio in contracting, put the auxiliary materials such as Chinese wax into and receive cream, emplastrum is made.Both treatment of the present invention
The paste of palace myomata and lobular hyperplasia.
Application method of the present invention: take cream agent is externally applied to the midpoint that pubis upper limb is connect with navel.It changes within 24 hours primary.
Drug of the present invention has the function of promoting qi circulation and removing obstruction in the collateral, dispelling stasis of blood and stimulating the menstrual flow, antalgic, promoting blood circulation dehumidifying, and good analgesic effect,
It is cheap, it has no toxic side effect, easy to use, which treats by the way of can reduce Western medicine to patient body
Injury, mitigates the slight illness of patient, according to clinical 200 patient views statistics, uses one course for the treatment of total effective rate of drug of the present invention
85%, two course for the treatment of total effective rates 95%.
Specific embodiment
Embodiment one: olibanum 60g, myrrh 60g, ground beetle 60g, rhizoma cyperi 70g, Fructus Liquidambaris 60g, honeycomb 70g, mountain rib 60g,
Curcuma zedoary 60g, Radix Aconiti 40g, saltcake 160g, leech 60g.
Embodiment two: olibanum 70g, myrrh 70g, ground beetle 60g, rhizoma cyperi 70g, Fructus Liquidambaris 60g, honeycomb 80g, mountain rib 50g,
Curcuma zedoary 80g, Radix Aconiti 50g, saltcake 140g, leech 50g.
Embodiment three: olibanum 80g, myrrh 60g, ground beetle 60g, rhizoma cyperi 80g, Fructus Liquidambaris 60g, honeycomb 60g, mountain rib 70g,
Curcuma zedoary 60g, Radix Aconiti 50g, saltcake 150g, leech 70g.
Here is clinical statistics data of the patient using drug of the present invention:
One, general information
It accepts out-patient 200 for medical treatment, patient is randomly divided into observation group and control group each 100, max age 50 years old, most off year
Age 20 years old, course of disease some months was differed by several years.The items basic document such as two groups of patient ages, courses of disease is essentially identical, and difference is without system
Meter learns meaning (P > 0.05).
Two, diagnostic criteria
1, there are the varied history of the moon, pressure symptom, hyper-menorrhea or menstruation extend；
2, gynaecological examination uterus increases, and matter is hard or surface imperfection；
3, laboratory, which checks, anaemia；
4,5-7 days before menstrual onset, breast fullness pain, menstrual onset swollen breasts are alleviated, or even disappear.
5, ultrasound diagnosis shows solid tumor mass.
Three, treatment method:
1, observation group weighs bulk pharmaceutical chemicals and treats by invention implementation method, take cream agent is externally applied to according to Medications Example one of the present invention
The midpoint that pubis upper limb is connect with navel.It changes within 24 hours once, 7 days as a course for the treatment of.
2, control group uses conventional western medicine mifepristone in treating, 7 days as one therapeutic course.
Four, efficacy assessment standard:
1, cure: clinical symptoms disappear, and ultrasound diagnosis is without solid tumor mass；
2, improve: clinical symptom relief, ultrasound diagnosis solid tumor mass are obviously reduced；
3, invalid: clinical symptoms are not felt any better person, and ultrasound diagnosis solid tumor mass is constant or becomes larger.
Five, treatment results count:
Control group result statistics
Use the situation of effect comparison of the Chinese materia medica preparation two courses for the treatment of, two groups of patients
| Group | Number of cases | It cures [n (%)] | It improves [n (%)] | [n (%)] in vain | Total effective rate (%) |
| Observation group | 100 | 68(68) | 27(27) | 5(5) | 95 |
| Control group | 100 | 50(50) | 34(34) | 16(16) | 84 |
Wherein: total effective rate=cure rate+improvement rate
Treatment total effective rate by comparing two groups of patients can be found that observation group is apparently higher than control group, thus illustrates, this hair
Bright Chinese medicine has good clinical effectiveness in treatment fibroid and lobular hyperplasia, can effectively improve the cure rate for the treatment of, imitates
Fruit is significant, cheap, has no adverse reaction and any toxic side effect, has a vast market application prospect.
Typical case and curative effect:
Case one, patient Mr. Wang, female, 36 years old, it is medical to come here on March 20th, 2018 by people from Shanghai City.: there was stream of people's history in main suit,
Nearest half a year hyper-menorrhea, menostaxis one week or so, has clot, and go to hospital to do ultrasound diagnosis with aching with underbelly, examine
Break as fibroid.Then carry out here treatment, using made preparation in the embodiment of the present invention one and selected preparation method, use
After medicine 7 days, pain disappears, and restores good, continues medication 7 days, and ultrasound diagnosis is normal range (NR), other clinical symptoms disappear, uterus
Myomata recovery from illness, Effect of follow-up visit by telephone half a year do not recur.
Case two, patient Lee, female, 31 years old, people from Zhejiang.It is medical to come here on May 20th, 2018, symptom is such as after diagnosing
Under: 1 youngster is given birth to, nearest 7 months, occasionally there were extension one week in hyper-menorrhea, menstrual period, and menstrual period abdomen aches, 5-7 before menstrual onset
It, breast fullness pain, gynaecological examination uterus increases, and B ultrasound detection is diagnosed as fibroid and lobular hyperplasia.Using the embodiment of the present invention
Made preparation and selected preparation method in two, after medication 7 days, symptom decline, pain disappears, and restores good, continues medication
7 days, clinical normal disappearance, ultrasound diagnosis was normal, thoroughly cures, and Effect of follow-up visit by telephone half a year does not recur.
Claims (4)
1. a kind of for treating the Chinese materia medica preparation of fibroid and lobular hyperplasia, which is characterized in that the Chinese materia medica preparation is by following
The drug of parts by weight is made: olibanum 50-70g, myrrh 50-70g, ground beetle 50-70g, rhizoma cyperi 60-80g, Fructus Liquidambaris 50-70g,
Honeycomb 60-80g, mountain rib 50-70g, curcuma zedoary 50-70g, Radix Aconiti 30-50g, saltcake 150-170g, leech 50-70g.
2. according to claim 1 for treating the Chinese materia medica preparation of fibroid and lobular hyperplasia, which is characterized in that by with
The drug of lower parts by weight is made: olibanum 60g, myrrh 60g, ground beetle 60g, rhizoma cyperi 70g, Fructus Liquidambaris 60g, honeycomb 70g, mountain rib
60g, curcuma zedoary 60g, Radix Aconiti 40g, saltcake 160g, leech 60g.
3. according to claim 1 or 2 for treating the Chinese materia medica preparation of fibroid and lobular hyperplasia, it is characterised in that:
The Chinese materia medica preparation is paste.
4. a kind of for treating the preparation method of the Chinese materia medica preparation of fibroid and lobular hyperplasia, which is characterized in that preparation method
It is as follows:
Step 1: pressing weight of the present invention, takes olibanum, and myrrh, saltcake cross 200 meshes, spare；
Step 2: pressing weight of the present invention, ground beetle, honeycomb, Radix Aconiti, leech medicinal material taken to be placed in casserole, is added 3 times
The water of volume intense fire infusion 20-30 minutes, turns mild fire infusion 30-40 minutes, filter liquor, and infusion three times, merges three times repeatedly
Filtrate is spare；
Step 3: weight proportion of the present invention is pressed, takes curcuma zedoary, mountain rib, Fructus Liquidambaris, rhizoma cyperi medicinal material to be placed in casserole, 3 times of volumes is added
Water, after intense fire infusion 20-30 minutes, addition turn mild fire infusion 30 ~ 40 minutes filtrate, repeatedly infusion merges three times gained filter
Liquid, it is spare；
Step 4: merge Step 2: step 3 obtained by filtrate and with step 1 obtained by powder, mixing, stir evenly, by medicine soup carry out it is dense
75 ° of alcohol are added according to 20:1 ratio in contracting, put the auxiliary materials such as Chinese wax into and receive cream, emplastrum is made, both treatment of the present invention is sub
The paste of palace myomata and lobular hyperplasia.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939523A (en) * | 2006-09-23 | 2007-04-04 | 吉慧文 | Chinese-medicinal preparation for treating hysteromyoma and its making method |
| CN101129901A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Traditional Chinese medicine composition for treating hysteromyoma |
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- 2019-01-28 CN CN201910079046.XA patent/CN109528985A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939523A (en) * | 2006-09-23 | 2007-04-04 | 吉慧文 | Chinese-medicinal preparation for treating hysteromyoma and its making method |
| CN101129901A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Traditional Chinese medicine composition for treating hysteromyoma |
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| Title |
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| 王艳萍: "子宫肌瘤的中医药治疗策略", 《中国社区医师》 * |
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Application publication date: 20190329 |