CN109528950A - 一种驱寒通痹片及其制备方法 - Google Patents
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Abstract
本发明属于医药技术领域，公开了一种驱寒通痹片及其制备方法；所述的驱寒通痹片按照重量由雷公藤10‑500g、制川乌10‑100g、制草乌10‑100g、制附子10‑100g、细辛10‑100g、木瓜10‑100g、桂枝10‑100g、蜈蚣10‑100g、薏苡仁10‑100g、麸炒白术10‑100g和防风10‑100g组成。本发明具有温经散寒，活血通络的功效；用于类风湿性关节炎寒湿痹阻型；本发明中雷公藤生物碱及甲素、乙素、乌头类生物碱等具有抗炎及中枢性镇痛作用；本发明具有免疫抑制作用；调整血液循环，有利于散热发汗；有镇静及轻微降压作用。
Description
技术领域
本发明属于医药技术领域，尤其涉及一种驱寒通痹片及其制备方法。
背景技术
目前，业内常用的现有技术是这样的：
类风湿关节炎(RA)是一种病因未明的慢性、以炎性滑膜炎为主的系统性疾病。其特征是四肢大小关节的多关节、对称性、侵噬性关节炎，常伴有血清类风湿因子阳性及抗黄胍氨酸肽抗体阳性，如控制不佳可出现关节畸形功能丧失，甚者脏器受累危及生命。
目前类风湿关节炎的治疗以抗炎止痛、免疫抑制延缓病情发展，预防关节骨质破坏畸形，但长时间口服，副作用较大，常常引起脏器功能损伤；在使用消炎止痛药的过程中(非甾体消炎药、激素)，往往会带来比较明显的毒副作用，导致肝肾功能受损、血液系统受累、骨质疏松、消化性溃疡等新的问题。
现有技术存在的问题是：
1、在长期使用非甾体消炎药或激素过程中，患者往往会出现消化系统症状(恶心、呕吐、纳呆)，甚者严重可出现消化性溃疡。
2、目前RA的控制主要依靠免疫抑制剂(甲氨喋呤片、来氟米特片)，长期使用，患者会出现免疫力低下，特别容易诱发各种感染。
3、目前使用的中药制剂如白芍总苷胶囊、正清风痛宁胶囊虽然有一定的疗效，但是没有对病症分型治疗，用药宽泛，不能针对性治疗。
4、RA患者除疼痛可以使用抗炎止痛药缓解症状以外，晨僵、怕冷、肢凉等症状不能很好得到解决。
解决缺陷：
1、在长期治疗过程中能够缓解疼痛，最大程度较少对消化道的毒副作用，而且对胃黏膜具有保护作用；
2、对于服用免疫抑制剂导致免疫力低下者，可以对免疫力进行双向调节；
3、整体治疗，除疼痛可以控制外，也可以兼顾合并症。
意义：
1、功补兼施，可长期口服：驱寒通痹片为复方制剂，除川乌、草乌、雷公藤等具有祛寒邪、通经络外，还配伍有白术、薏苡仁、木瓜等健脾益气化湿药物；长期口服攻划之药，可以耗伤气血，在使用过程中配伍健脾益气之品，以补后天气血，使驱邪而不伤正，相得益彰。
2、辩证施治，达到精准治疗：辨明寒热、虚实是施治的基础，中药的使用是以中医理论为指导原则，才能做到精准治疗。
发明内容
针对现有技术存在的问题，本发明提供了一种驱寒通痹片及其制备方法。
本发明是这样实现的，一种驱寒通痹片由雷公藤10-500g、制川乌10-100g、制草乌10-100g、制附子10-100g、细辛10-100g、木瓜10-100g、桂枝10-100g、蜈蚣10-100g、薏苡仁10-100g、麸炒白术10-100g和防风10-100g组成。除川乌、草乌、雷公藤等具有祛寒邪、通经络外，还配伍有白术、薏苡仁、木瓜等健脾益气化湿药物；长期口服攻划之药，可以耗伤气血，在使用过程中配伍健脾益气之品，以补后天气血，使驱邪而不伤正，相得益彰。
本发明的另一目的在于提供一种驱寒通痹片的制备方法，具体包括以下步骤：
步骤一：选取优质的雷公藤、制川乌、制草乌、制附子、细辛、木瓜、桂枝、蜈蚣、薏苡仁、麸炒白术和防风，进行除杂、杀菌；
步骤二：取上述雷公藤(6％的量)和其他十味药各三分之一量干燥后利用粉碎机依次进行粉碎，过100目筛，备用；
步骤三：剩余药材加水煎煮两次，每次2小时，合并煎液，滤过，滤液浓缩至适宜程度，加入上述细粉，混匀，制成颗粒，干燥，压制成1000片；
步骤四：制片后包糖衣，经杀菌、包装，制得清热通痹片。
进一步，步骤一中，杀菌，通过喷洒75％的酒精对药材进行杀菌处理。
进一步，粉碎机选用超微粉碎机。
进一步，步骤五中，糖衣为普通药用糖衣。
综上所述，本发明的优点及积极效果为：
本发明具有温经散寒，活血通络的功效；用于类风湿性关节炎寒湿痹阻型。
(1)功补兼施，可长期口服：驱寒通痹片为复方制剂，除川乌、草乌、雷公藤等具有祛寒邪、通经络外，还配伍有白术、薏苡仁、木瓜等健脾益气化湿药物；长期口服攻划之药，可以耗伤气血，在使用过程中配伍健脾益气之品，以补后天气血，使驱邪而不伤正，相得益彰。
(2)辩证施治，达到精准治疗：辨明寒热、虚实是施治的基础，中药的使用是以中医理论为指导原则，才能做到精准治疗。
附图说明
图1是本发明实施例提供的驱寒通痹片的制备方法流程图。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
本发明实施例提供的驱寒通痹片按照重量由雷公藤10-500g、制川乌10-100g、制草乌10-100g、制附子10-100g、细辛10-100g、木瓜10-100g、桂枝10-100g、蜈蚣10-100g、薏苡仁10-100g、麸炒白术10-100g和防风10-100g组成。
下面结合附图对本发明的应用原理做详细描述。
本发明实施例提供的驱寒通痹片的制备方法，具体包括以下步骤：
S101：选取优质的雷公藤、制川乌、制草乌、制附子、细辛、木瓜、桂枝、蜈蚣、薏苡仁、麸炒白术和防风，进行除杂、杀菌；
S102：取上述雷公藤(6％的量)和其他十味药各三分之一量干燥后利用粉碎机依次进行粉碎，过100目筛，备用；
S103：剩余药材加水煎煮两次，每次2小时，合并煎液，滤过，滤液浓缩至适宜程度，加入上述细粉，混匀，制成颗粒，干燥，压制成1000片；
S104：制片后包糖衣，经杀菌、包装，制得清热通痹片。
步骤S101中，本发明实施例提供的杀菌，通过喷洒75％的酒精对药材进行杀菌处理。
本发明实施例提供的粉碎机选用超微粉碎机。
步骤S104中，本发明实施例提供的糖衣为普通药用糖衣。
本发明实施例提供的性状为：本品为糖衣片；除去糖衣后显棕褐色，味苦微甜。
下面结合具有的药理作用对本发明的应用原理进行进一步详细说明；
雷公藤，性味苦、辛，凉。有大毒。功能主治祛风，解毒，杀虫。用于治疗风湿性关节炎和类风湿关节炎，外用治疗皮肤发痒。
制川乌，性味辛、苦，热；归心、肝、肾、脾经；功能主治同川乌。祛风除湿，温经止痛。用于风寒湿痹，关节疼痛，心腹冷痛，寒疝作痛，麻醉止痛。
制草乌，辛、苦，热；归心、肝、肾、脾经；功能主治祛风除湿，温经止痛。用于风寒湿痹，关节疼痛，心腹冷痛,寒疝作痛，麻醉止痛。
制附子，辛、甘，大热；有毒。归心、肾、脾经。具有回阳救逆，补火助阳，逐风寒湿邪的功效。用于亡阳虚脱，肢冷脉微，阳痿，宫冷，心腹冷痛，虚寒吐泻，阴寒水肿，阳虚外感，寒湿痹痛
细辛，性味辛，温。归心、肺、肾经。功能主治祛风散寒，通窍止痛，温肺化饮。用于风寒感冒，头痛，牙痛，鼻塞鼻渊，风湿痹痛，痰饮喘咳。
木瓜，性味酸，温。归肝、脾经。功能主治平肝舒筋，和胃化湿。用于湿痹拘挛，腰膝关节酸重疼痛，吐泻转筋，脚气水肿。
桂枝，性味辛、甘，温。归心、肺、膀胱经。功能主治发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。
蜈蚣，性味辛，温；归肝经。功能主治息风镇痉，功毒散结，通络止痛。用于小儿惊风，抽搐痉挛，中风口歪，半身不遂，破伤风，风湿顽痹，疮疡，瘰疬，毒蛇咬伤。
薏苡仁，性味甘、淡，凉。归脾、胃、肺经。功能主治健脾渗湿，除痹止泻，清热排浓。用于水肿，脚气，小便不利，湿痹拘挛，脾虚泄泻，肺痈，肠痈；扁平疣。
麸炒白术，具有能缓和燥性，借麸入中，增强健脾、消肿的作用。
防风，辛、甘，微温。归膀胱、肝、脾经。功与主治：祛风解表，胜湿止痛，止痉。用于感冒头痛，风湿痹痛，风疹瘙痒，破伤风。
方中川乌、草乌、雷公藤等祛寒邪、通经络，另配伍有白术、薏苡仁、木瓜等健脾益气化湿药物；使驱邪而不伤正，相得益彰
下面结合具体实施例对本发明的应用原理进行进一步详细说明；
实施例1；
本发明实施例提供的驱寒通痹片按照重量由雷公藤10g、制川乌10g、制草乌10g、制附子10g、细辛10g、木瓜10g、桂枝10g、蜈蚣10g、薏苡仁10-100g、麸炒白术10g和防风10g组成。
实施例2；
本发明实施例提供的驱寒通痹片按照重量由雷公藤500g、制川乌100g、制草乌100g、制附子100g、细辛100g、木瓜1100g、桂枝100g、蜈蚣10-100g、薏苡仁100g、麸炒白术100g和防风100g组成。
实施例3；
本发明实施例提供的驱寒通痹片按照重量由雷公藤55g、制川乌55g、制草乌55g、制附子55g、细辛55g、木瓜55g、桂枝55g、蜈蚣55g、薏苡仁55g、麸炒白术55g和防风55g组成。
下面结合临床实施例对本发明的应用效果作详细的描述。
临床实施例一：黄某，男，45岁。
于2018年10月18日因四肢关节肿痛入院。中医诊断：尪痹，寒湿痹阻型；西医诊断：类风湿关节炎。
结果：中医治温经散寒、通络止痛为法，方用乌头汤加减配合驱寒通痹片(每日3次，每次3片)、活血壮筋片治疗。患者四肢关节肿痛较前减轻，病情好转出院。
临床实施例二：选取风湿寒性关节痛患者共计60例，随机分成两组，即治疗组和对照组。治疗组30例中，男性12例，女性18例；年龄31～65岁，平均年龄41.4岁；病程最短者1个月，最长者达30年，平均6.5年。对照组30例中，男性12例，女性18例；年龄22～69岁，平均42.8岁；病程最短者1.5月，最长者达28年，平均为6.3年。
治疗：两组均采用外用中药熏洗常规治疗。治疗组：每日中药熏洗一次，另加祛寒通痹片(由我院制剂室提供，主要成份包含雷公藤、川乌、草乌、制附片、黄芪、鸡血藤、木瓜、桂枝、蜈蚣、薏苡仁、白术、防风)，每次4片，每日三次。20天为1疗程，根据病情可连续服用1～2个疗程，治疗期间停用其他药物。对照组：每日中药熏洗一次，另加小活络丸，每次1丸，每日2次。15天为1疗程，根据病情可连续服用1～2个疗程，治疗期间停用其他药物。
结果：
实验室指标变化，包括：
血沉：治疗组30例中增高者6例，恢复正常4例，恢复正常率66.7％；对照组30例中增高者5例，恢复正常者2例，恢复正常率40％。
治疗结果，包括：
治疗组30例患者，近期治愈者16例，显效者10例，有效者3例，无效者1例，总有效率96.66％；
对照组30例患者，近期治愈者7例，显效者6例，有效者12例，无效者5例，总有效率83.33％；
综上，祛寒通痹片治疗风湿寒性关节痛有显著疗效。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
Claims (5)
1.一种驱寒通痹片，其特征在于，所述的驱寒通痹片由雷公藤10-500g、制川乌10-100g、制草乌10-100g、制附子10-100g、细辛10-100g、木瓜10-100g、桂枝10-100g、蜈蚣10-100g、薏苡仁10-100g、麸炒白术10-100g和防风10-100g组成。
2.一种如权利要求1所述驱寒通痹片的制备方法，其特征在于，所述驱寒通痹片的制备方法包括以下步骤：
步骤一：选取雷公藤、制川乌、制草乌、制附子、细辛、木瓜、桂枝、蜈蚣、薏苡仁、麸炒白术和防风，进行除杂、杀菌；
步骤二：取上述雷公藤6％的量和其他十味药各三分之一量干燥后利用粉碎机依次进行粉碎，过100目筛，备用；
步骤三：剩余药材加水煎煮两次，每次2小时，合并煎液，滤过，滤液浓缩至适宜程度，加入细粉，混匀，制成颗粒，干燥，压制成1000片；
步骤四：制片后包糖衣，经杀菌、包装，制得清热通痹片。
3.如权利要求2所述的驱寒通痹片的制备方法，其特征在于，所述步骤一中，杀菌，通过喷洒75％的酒精对药材进行杀菌处理。
4.如权利要求2所述的驱寒通痹片的制备方法，其特征在于，所述粉碎机选用超微粉碎机。
5.如权利要求2所述的驱寒通痹片的制备方法，其特征在于，所述步骤四中，糖衣为普通药用糖衣。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103310A (zh) * | 1994-04-27 | 1995-06-07 | 王德志 | 蠲络痛胶丸 |
| CN101024050A (zh) * | 2006-02-23 | 2007-08-29 | 秦永河 | 一种治疗风湿类风湿性关节炎的药物组合物 |
| CN106039109A (zh) * | 2016-07-11 | 2016-10-26 | 张绪伟 | 防治寒湿阻络型的类风湿性关节炎的中药药酒 |
-
2018
- 2018-12-13 CN CN201811524730.6A patent/CN109528950A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103310A (zh) * | 1994-04-27 | 1995-06-07 | 王德志 | 蠲络痛胶丸 |
| CN101024050A (zh) * | 2006-02-23 | 2007-08-29 | 秦永河 | 一种治疗风湿类风湿性关节炎的药物组合物 |
| CN106039109A (zh) * | 2016-07-11 | 2016-10-26 | 张绪伟 | 防治寒湿阻络型的类风湿性关节炎的中药药酒 |
Non-Patent Citations (5)
| Title |
|---|
| 乐文博 等: "桂枝附子汤加味配合外用药治疗风湿寒性关节炎60例" * |
| 刘天骥 等: "反药配伍运用二则" * |
| 李拥: "以寒热为纲辨证治疗类风湿关节炎148例报告" * |
| 李梅梅 等: "中药熏蒸合驱寒通痹片治疗风湿寒痹60例临床观察" * |
| 杨祎: "驱寒通痹片治疗尪痹（寒湿痹阻证）50例临床观察" * |
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Application publication date: 20190329 |