CN104288597A - 一种治疗带状疱疹的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗带状疱疹的中药组合物，其特征是包括以下重量份的原料药：当归12-20份、绿萼梅8-12份、玄参8-12份、连翘12-18份、秋葵全株25-40份、月见草3-8份、薏米5-15份、鱼腥草10-20份、瓜蒌40-50份、黄芪15-25份、甘草3-10份。本发明药物组合物根据带状疱疹的致病机理研发而得，配方中各原料药协同起效，疗效显著，具有活血化瘀、疏肝散结、清热除湿、补脾益气、消肿止痛功效，能从根本上解除病因，对带状疱疹以及带状疱疹后遗神经痛有很好的治疗作用。
Description
技术领域
本发明涉及一种中药组合物，具体涉及一种能够治疗带状疱疹的中药组合物，属于中药技术领域。
背景技术
带状疱疹是由水痘-带状疱疹病毒HSV引起的急性感染性皮肤病，病毒经呼吸道黏膜进入血液形成病毒血症，发生水痘或呈隐性感染，以后病毒可长期潜伏在脊髓后根神经节或者颅神经感觉神经节内，当机体受到某种刺激（如创伤、疲劳、恶性肿瘤或病后虚弱等）导致机体抵抗力下降时，潜伏病毒被激活，沿感觉神经轴索下行到达该神经所支配区域的皮肤内复制产生水疱，同时受累神经发生炎症、坏死，产生神经痛。这种病毒侵犯后遗留炎症或神经受损所导致的神经痛统称为带状疱疹后遗神经痛，这种神经痛的自我恢复常常需要半年以上时间，因此不加干预的话这种后遗疼痛是比较顽固的，且有一些病人因长期疼痛而出现精神紧张、情绪激动、失眠等现象，进一步加剧了内分泌和神经系统的功能紊乱，导致神经恢复减慢甚至抵抗力下降，疱疹复发，疼痛经久不愈。
西医治疗通常用抗病毒药物和抗神经痛药物，一般治疗时间长，疗效不是很理想。中医认为本病多由情志内伤，肝气郁结化火，火毒外泛肌肤，或脾失健运，蕴湿化热，湿热蕴结皮肤所致；老年人血虚肝旺，湿热毒盛，气滞血瘀，肌肤失养，也可导致本病。因此，对患者施加活血化瘀、疏肝散结、清热除湿、补脾益气、消肿止痛的药物配伍将从根本上治疗本病症，且快速起效。
发明内容
本发明的目的是提供一种治疗带状疱疹的中药组合物，该中药组合物能够对带状疱疹及其后遗神经痛起到很好的治疗作用，疗效显著。
本发明具体技术方案如下：
一种治疗带状疱疹的中药组合物，其特征是包括以下重量份的原料药：当归12-20份、绿萼梅8-12份、玄参8-12份、连翘12-18份、秋葵全株25-40份、月见草3-8份、薏米5-15份、鱼腥草10-20份、瓜蒌40-50份、黄芪15-25份、甘草3-10份。
上述中药组合物中，优选包括以下重量份的原料药：当归15份、绿萼梅10份、玄参10份、连翘15份、秋葵全株30份、月见草5份、薏米10份、鱼腥草15份、瓜蒌45份、黄芪20份、甘草5份。
发明人经过多年临床研究，几经修改，得到了本发明配方，通过配方中各原料的协同配合，起到了活血化瘀、疏肝散结、清热除湿、补脾益气、消肿止痛的功效，经反复验证，对带状疱疹以及其后遗神经痛作用迅速，疗效显著。各原料药功效如下：
当归，具有补血、活血、调经止痛的功效，能够护肤美容，抗炎镇痛，保肝利胆。
绿萼梅，疏肝，和胃，化痰。治梅核气，肝胃气痛，食欲不振，头晕，瘰疬。
玄参，具有清热凉血、滋阴降火、解毒散结的功效。
连翘，具有清热解毒，消肿散结，疏散风热。主治痈肿疮毒，痰核瘰疬，外感风热，温病初起，热淋涩痛等。
秋葵，又名羊角豆、咖啡黄葵、毛茄，其全株包括秋葵的根、叶和果荚，秋葵富含丰富的维生素，具有清热利湿、保护肝脏、营养皮肤的作用。
月见草，具有活血通络、息风平肝、消肿敛疮的作用。
薏苡仁，具有健脾止泻、除痹止痛、清热排脓、清热利湿的作用。
鱼腥草，具有清热解毒，利尿消肿的作用。
瓜蒌，又名栝楼，清热涤痰，宽胸散结，润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满；乳痈，肺痈，肠痈肿痛，大便秘结。
黄芪，具有补气固表、利尿托毒、排脓、敛疮生肌的功效。
甘草，具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药的作用。
进一步的，在此基础上加入干月季花、鱼鳔、板蓝根。月季花祛瘀行气、活血止痛、消肿解毒；鱼鳔补肾益精、滋养筋脉、散瘀消肿、止血、美肤；板蓝根清热解毒。加入这三种原料药，可以提高疗效，形成的配方如下（重量份）：当归12-20份、绿萼梅8-12份、玄参8-12份、连翘12-18份、秋葵全株25-40份、月见草3-8份、薏米5-15份、鱼腥草10-20份、瓜蒌40-50份、黄芪15-25份、甘草3-10份、干月季花10-18份、鱼鳔22-30份、板蓝根3-8份。优选：当归15份、绿萼梅10份、玄参10份、连翘15份、秋葵全株30份、月见草5份、薏米10份、鱼腥草15份、瓜蒌45份、黄芪20份、甘草5份、干月季花15份、鱼鳔25份、板蓝根5份。
本发明中药组合物制备方法简单，可以将各原料药直接用水煎成汤剂服用，也可以将煎成的汤剂浓缩除水，按照现有方法制成丸剂、颗粒剂、片剂等剂型。
本发明药物组合物根据带状疱疹的致病机理研发而得，配方中各原料药协同起效，疗效显著，具有活血化瘀、疏肝散结、清热除湿、补脾益气、消肿止痛的功效，能从根本上解除病因，对带状疱疹以及带状疱疹后遗神经痛有很好的治疗作用。
具体实施方式
下面，通过具体实施例对本发明进行进一步的说明，应该明白的是，下述说明仅是为了解释本发明，并不对其内容进行限定。
实施例1
本发明组合物原料药配方为：当归15g、绿萼梅10g、玄参10g、连翘15g、秋葵全株30g、月见草5g、薏米10g、鱼腥草15g、瓜蒌45g、黄芪20g、甘草5g。
制备方法为：取上述各原料药，加水没过原料药，浸泡30min后大火煎煮，水开后转中火再煮30min；按此方法水煎两次，将所得汤剂合并混匀，每天早晚各服用一半。
实施例2
本发明组合物原料药配方为：当归12g、绿萼梅8 g、玄参12g、连翘12g、秋葵全株40g、月见草3g、薏米15g、鱼腥草10g、瓜蒌50g、黄芪15g、甘草10g。
按照实施例1的方法将各原料药煎成汤剂，早晚服用。
实施例3
本发明组合物原料药配方为：当归20g、绿萼梅12 g、玄参8g、连翘18g、秋葵全株25g、月见草8g、薏米5g、鱼腥草20g、瓜蒌40g、黄芪25g、甘草3g。
按照实施例1的方法将各原料药煎成汤剂，早晚服用。
实施例4
本发明组合物原料药配方为：当归15g、绿萼梅10 g、玄参10g、连翘15g、秋葵全株30g、月见草5g、薏米10g、鱼腥草15g、瓜蒌45g、黄芪20g、甘草5g、干月季花15g、鱼鳔25g、板蓝根5g。
按照实施例1的方法将各原料药煎成汤剂，早晚服用。
实施例5
本发明组合物原料药配方为：当归12g、绿萼梅8 g、玄参12g、连翘12g、秋葵全株40g、月见草3g、薏米15g、鱼腥草10g、瓜蒌50g、黄芪15g、甘草10g、干月季花10g、鱼鳔30g、板蓝根3g。
按照实施例1的方法将各原料药煎成汤剂，早晚服用。
实施例6
本发明组合物原料药配方为：当归20g、绿萼梅12 g、玄参8g、连翘18g、秋葵全株25g、月见草8g、薏米5g、鱼腥草20g、瓜蒌40g、黄芪25g、甘草3g、干月季花18g、鱼鳔22g、板蓝根8g。
按照实施例1的方法将各原料药煎成汤剂，早晚服用。
本发明中药组合物针对带状疱疹研发，通过全面调整各脏器功能，能够从根本上除去病因。经过临床验证，本发明组合物起效迅速，疗效显著。
临床实验
一、治疗带状疱疹临床实验
1、病例来源
从本市某医院选取228名带状疱疹患者进行实验，其中男性134名，女性94名，年龄18-65岁，平均年龄42.3岁。所有患者均确诊为带状疱疹，病程在10天以内。 根据疱疹侵犯神经部分分：三叉神经区域 58人，肋间神经区域 74人，臂丛神经区域42人， 坐骨神经区域54人。
2、治疗方法
将上述患者平均分为4组，各组患者之间年龄、性别、疱疹区域大小、神经痛疼状况无显著性差异。
将各组患者分别使用实施例1、2、4、5的药物进行治疗，药物煎成汤剂服用，连煎两次，药液混合均匀分早晚两次服用。
3、疗效评定
治愈：疱疹结痂脱落，痛疼完全缓解；
显效：疱疹干瘪结痂30%以上，疼痛明显减轻；
无效：疱疹干瘪结痂30%以下，疼痛未能明显缓解。
4、实验结果
连续治疗7天后，各组患者病情变化如下表1所示：
二、治疗带状疱疹后遗神经痛临床实验
1、从本市某医院选取有带状疱疹病史，皮损消失4周后仍遗留原皮疹分布区域的针刺、灼烧疼痛等后移神经痛的患者。患者共124名，其中男性60例，女性64例，患者年龄18-60岁，平均40.1岁。患者后遗神经痛病程3个月～10个月，平均5.8个月。
2、治疗方法
将上述患者平均分为4组，各组患者之间无统计学差异。
将各组患者分别使用实施例1、2、4、5的药物进行治疗，药物煎成汤剂服用，连煎两次，药液混合均匀分早晚两次服用。
3、疗效评定
治愈：临床体征消失，无痛疼后遗症；
显效：疼痛明显减轻；
无效：疼痛无缓解。
4、实验结果
连续治疗10天后，各组患者病情变化如下表3所示：
从上述实验数据可以看出，本发明各实施例对带状疱疹及其引起的后遗神经痛有很好的治疗作用，作用迅速，见效快，疗效显著，其中实施例4的药物效果最佳。
Claims (4)
1.一种治疗带状疱疹的中药组合物，其特征是包括以下重量份的原料药：当归12-20份、绿萼梅8-12份、玄参8-12份、连翘12-18份、秋葵全株25-40份、月见草3-8份、薏米5-15份、鱼腥草10-20份、瓜蒌40-50份、黄芪15-25份、甘草3-10份。
2.根据权利要求1所述的中药组合物，其特征是包括以下重量份的原料药：当归15份、绿萼梅10份、玄参10份、连翘15份、秋葵全株30份、月见草5份、薏米10份、鱼腥草15份、瓜蒌45份、黄芪20份、甘草5份。
3.根据权利要求1或2所述的中药组合物，其特征是还包括以下重量份的原料药：干月季花10-18份、鱼鳔22-30份、板蓝根3-8份。
4.根据权利要求3所述的中药组合物，其特征是还包括以下重量份的原料药：干月季花15份、鱼鳔25份、板蓝根5份。
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