CN109528938A - A kind of Chinese medicine that treating chronic kidney and its oral preparation - Google Patents

A kind of Chinese medicine that treating chronic kidney and its oral preparation Download PDF

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CN109528938A
CN109528938A CN201811431060.3A CN201811431060A CN109528938A CN 109528938 A CN109528938 A CN 109528938A CN 201811431060 A CN201811431060 A CN 201811431060A CN 109528938 A CN109528938 A CN 109528938A
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parts
radix
chinese medicine
peach kernel
chronic kidney
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李建国
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/75Rutaceae (Rue family)
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    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention belongs to field of traditional Chinese medicine preparations, especially a kind of Chinese medicine for treating chronic kidney and its oral preparation, including the raw material of following parts by weight: 3-6 parts of radix bupleuri, 1-1.5 parts of the dried immature fruit of citron orange, 3-6 parts of radix paeoniae rubra, 3-6 parts of Radix Glycyrrhizae, 5-10 parts of Radix Angelicae Sinensis, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of Radix Rehmanniae, 5-10 parts of peach kernel, 20-30 parts of safflower, 10-15 parts of radix achyranthis bidentatae, 1-1.5 parts of Verbena officinalis, 10-15 parts of motherwort, 5-10 parts of rhizoma imperatae, fine powder is worn into peach kernel peeling, by safflower, radix achyranthis bidentatae, radix bupleuri, the dried immature fruit of citron orange, radix paeoniae rubra, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong etc. is cleaned, it adds water to cook three times, it obtains decocting mixed extract, mixed extract will be decocted and stand 12 hours, extracting solution Chinese medicine slag is filtered, obtain concentrate, it is in mixing medicine that preparation in concentrate, which is added, in peach kernel powder Agent obtains medicinal preparation for oral administration.Clearing heat and cooling blood of the present invention, enriching yin, cooling and activating blood, the effect of activating microcirculation and removing stasis medicinal can be realized.

Description

A kind of Chinese medicine that treating chronic kidney and its oral preparation
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation more particularly to a kind of Chinese medicine for treating chronic kidney and its oral systems Agent.
Background technique
Chronic kidney disease (Chronic Kidney Disease, CKD) is clinically comprehensive including chronic glomerulonephritis, nephrosis Simulator sickness, membranous nephropathy, diabetic nephropathy, hypertensive nephropathy and various secondary nephrosis etc. have disease incidence height, suffer from blood of making up one's mind The feature that pipe disease illness rate is high, case fatality rate is high, in addition society is not high to the awareness of chronic kidney disease, and control rate is low, and trouble is made up one's mind The awareness of angiosis is low, has become the open health problem in the whole world at present.Chronic kidney disease illness rate rises year by year, serious shadow National life quality is rung, for chronic kidney disease as do not controlled in time, patient will progress into end-stage renal disease, need throughout one's life Row renal replacement therapies, consume a large amount of medical insurance funds, cause serious commercial to bear to individual, family, society, for chronic kidney Disease, doctor trained in Western medicine is mostly to control primary disease (glomerulonephritis, diabetes, hypertension etc.) at present, anticoagulant, platelet aggregation-against treatment Based on, though can delay the progress of part disease, most of patients curative effect is poor, is unable to control disease complications, while long-term Liver caused by oral western medicine preparation, renal damage and hemorrhage of digestive tract are difficult to avoid that traditional Chinese medical science great master Zheng Xin is proposed, kidney network numbness Resistance, accumulate in turbid poison be chronic kidney disease basic pathogenesis, so with " the more stasis of bloods of prolonged illness " argument, with this disease of activating blood and resolving stasis and treating, It is recorded according to Chinese medicine, safflower, radix achyranthis bidentatae, Radix Rehmanniae, Radix Rehmanniae etc. just have the effect of preferable activating microcirculation and removing stasis medicinal, and motherwort has sharp spleen The effect of kidney-nourishing, but existing not yet discovery uses safflower, radix achyranthis bidentatae, Radix Rehmanniae, Radix Rehmanniae and motherwort in the treatment of chronic kidney disease, More not it has been found that medicament is made in the cooperation of safflower, radix achyranthis bidentatae, Radix Rehmanniae, Radix Rehmanniae and motherwort, we design a kind of treat slowly thus The Chinese medicine of property kidney and its oral preparation solve the above problems.
Summary of the invention
The purpose of the present invention is to solve disadvantage existing in the prior art, and what is proposed a kind of treats chronic kidney Chinese medicine and its oral preparation.
To achieve the goals above, present invention employs following technical solutions:
A kind of Chinese medicine for treating chronic kidney, the raw material including following parts by weight: 3-6 parts of radix bupleuri, 1-1.5 parts of the dried immature fruit of citron orange, red 3-6 parts of Chinese herbaceous peony, 3-6 parts of Radix Glycyrrhizae, 5-10 parts of Radix Angelicae Sinensis, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of Radix Rehmanniae, 5-10 parts of peach kernel, 20-30 parts of safflower, ox 10-15 parts of knee, 1-1.5 parts of Verbena officinalis, 10-15 parts of motherwort, 5-10 parts of rhizoma imperatae.
Preferably, the raw material of following parts by weight: 40 parts of radix bupleuri, 1-1.5 parts of the dried immature fruit of citron orange, 3-6 parts of radix paeoniae rubra, 3-6 parts of Radix Glycyrrhizae, when Return 5-10 parts, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of Radix Rehmanniae, 5-10 parts of peach kernel, 20-30 parts of safflower, 10-15 parts of radix achyranthis bidentatae, Verbena officinalis 1-1.5 Part, 10-15 parts of motherwort, 5-10 parts of rhizoma imperatae.
Preferably, the raw material of following parts by weight: 4.5 parts of radix bupleuri, 1.25 parts of the dried immature fruit of citron orange, 4.5 parts of radix paeoniae rubra, 4.5 parts of Radix Glycyrrhizae, when Return 7.5 parts, 4.5 parts of Rhizoma Chuanxiong, 7.5 parts of Radix Rehmanniae, 7.5 parts of peach kernel, 25 parts of safflower, 12.5 parts of radix achyranthis bidentatae, 1.25 parts of Verbena officinalis, benefit mother 12.5 parts, 7.5 parts of Radix Rehmanniae of grass.
Preferably, the peach kernel uses powdered peach kernel powder.
Preferably, the weight ratio of the safflower, motherwort, rhizoma imperatae, radix achyranthis bidentatae and peach kernel is 6-10:5:3:5:3.
A kind of preparation method of oral preparation of Chinese traditional medicinal that treating chronic kidney, comprising the following steps:
S1 after removing the peel peach kernel, is put into grinding device, is fully ground into fine powder, spare;
S2, by safflower, radix achyranthis bidentatae, radix bupleuri, the dried immature fruit of citron orange, radix paeoniae rubra, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae, Verbena officinalis, motherwort, cogongrass It after root cleans up, adds water to cook three times, 3 hours for the first time, second 2 hours, third time 1 hour, obtains decoction mixing and mention Take liquid;
Extracting solution Chinese medicine slag is filtered, is concentrated behind the cooling and standings of decoction mixed extract 12 hours in S2 by S3 Liquid;
S4, it is in confection that preparation in the concentrate in S3, which is added, in the peach kernel powder in S1, obtains medicinal preparation for oral administration.
Compared with prior art, the beneficial effects of the present invention are: in the present invention, by radix bupleuri, the dried immature fruit of citron orange, radix paeoniae rubra, Radix Glycyrrhizae, when Return, Rhizoma Chuanxiong, Radix Rehmanniae, peach kernel, safflower, radix achyranthis bidentatae, Verbena officinalis, motherwort, rhizoma imperatae is to blood urine patient clearing heat and cooling blood, enriching yin, cool blood The effect of invigorating blood circulation, activating microcirculation and removing stasis medicinal can be realized.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiment of the present invention, instead of all the embodiments.
Embodiment one
A kind of Chinese medicine for treating chronic kidney, the raw material including following parts by weight: 3-6 parts of radix bupleuri, 1-1.5 parts of the dried immature fruit of citron orange, red 3-6 parts of Chinese herbaceous peony, 3-6 parts of Radix Glycyrrhizae, 5-10 parts of Radix Angelicae Sinensis, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of Radix Rehmanniae, 5-10 parts of peach kernel, 20-30 parts of safflower, ox 10-15 parts of knee, 1-1.5 parts of Verbena officinalis, 10-15 parts of motherwort, 5-10 parts of rhizoma imperatae.
A kind of preparation method of oral preparation of Chinese traditional medicinal that treating chronic kidney, comprising the following steps:
S1 after removing the peel peach kernel, is put into grinding device, is fully ground into fine powder, spare;
S2, by safflower, radix achyranthis bidentatae, radix bupleuri, the dried immature fruit of citron orange, radix paeoniae rubra, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae, Verbena officinalis, motherwort, cogongrass It after root cleans up, adds water to cook three times, 3 hours for the first time, second 2 hours, third time 1 hour, obtains decoction mixing and mention Take liquid;
Extracting solution Chinese medicine slag is filtered, is concentrated behind the cooling and standings of decoction mixed extract 12 hours in S2 by S3 Liquid;
S4, it is in confection that preparation in the concentrate in S3, which is added, in the peach kernel powder in S1, obtains medicinal preparation for oral administration.
Embodiment two
A kind of Chinese medicine for treating chronic kidney, the raw material including following parts by weight: 3-6 parts of radix bupleuri, 1 part of the dried immature fruit of citron orange, radix paeoniae rubra 3 Part, 3 parts of Radix Glycyrrhizae, 5 parts of Radix Angelicae Sinensis, 3 parts of Rhizoma Chuanxiong, 5 parts of Radix Rehmanniae, 5 parts of peach kernel, 20 parts of safflower, 10 parts of radix achyranthis bidentatae, 1 part of Verbena officinalis, motherwort 10 parts, 5 parts of rhizoma imperatae.
Embodiment three
A kind of Chinese medicine for treating chronic kidney, the raw material including following parts by weight: 3-6 parts of radix bupleuri, 1.5 parts of the dried immature fruit of citron orange, radix paeoniae rubra 6 Part, 6 parts of Radix Glycyrrhizae, 10 parts of Radix Angelicae Sinensis, 6 parts of Rhizoma Chuanxiong, 10 parts of Radix Rehmanniae, 10 parts of peach kernel, 30 parts of safflower, 15 parts of radix achyranthis bidentatae, 1.5 parts of Verbena officinalis, 15 parts of motherwort, 10 parts of rhizoma imperatae.
Example IV
A kind of Chinese medicine for treating chronic kidney, the raw material including following parts by weight: 3-6 parts of radix bupleuri, 1.25 parts of the dried immature fruit of citron orange, radix paeoniae rubra 4.5 parts, 4.5 parts of Radix Glycyrrhizae, 7.5 parts of Radix Angelicae Sinensis, 4.5 parts of Rhizoma Chuanxiong, 7.5 parts of Radix Rehmanniae, 7.5 parts of peach kernel, 25 parts of safflower, 12.5 parts of radix achyranthis bidentatae, 1.25 parts of Verbena officinalis, 12.5 parts of motherwort, 7.5 parts of rhizoma imperatae.
Experimental result is as in the table below
Patient uses blood content detection case in five weeks urines of oral agents
By upper table it is found that the oral agents that the present invention makes have preferable matter to Patients with Chronic Renal Disease (blood urine patient) Dose-effect fruit can effectively reduce the blood content of Urine in Patients.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (6)

1. a kind of Chinese medicine for treating chronic kidney, which is characterized in that the raw material including following parts by weight: 3-6 parts of radix bupleuri, dried immature fruit of citron orange 1- 1.5 parts, 3-6 parts of radix paeoniae rubra, 3-6 parts of Radix Glycyrrhizae, 5-10 parts of Radix Angelicae Sinensis, 3-6 parts of Rhizoma Chuanxiong, 5-10 parts of Radix Rehmanniae, 5-10 parts of peach kernel, safflower 20- 30 parts, 10-15 parts of radix achyranthis bidentatae, 1-1.5 parts of Verbena officinalis, 10-15 parts of motherwort, 5-10 parts of rhizoma imperatae.
2. a kind of Chinese medicine for treating chronic kidney according to claim 1 and its oral preparation, which is characterized in that including with The raw material of lower parts by weight: 40 parts of radix bupleuri, 1-1.5 parts of the dried immature fruit of citron orange, 3-6 parts of radix paeoniae rubra, 3-6 parts of Radix Glycyrrhizae, 5-10 parts of Radix Angelicae Sinensis, 3-6 parts of Rhizoma Chuanxiong, It is 5-10 parts of Radix Rehmanniae, 5-10 parts of peach kernel, 20-30 parts of safflower, 10-15 parts of radix achyranthis bidentatae, 1-1.5 parts of Verbena officinalis, 10-15 parts of motherwort, white 5-10 parts of lalang grass rhizome.
3. a kind of Chinese medicine for treating chronic kidney according to claim 1 and its oral preparation, which is characterized in that including with The raw material of lower parts by weight: 4.5 parts of radix bupleuri, 1.25 parts of the dried immature fruit of citron orange, 4.5 parts of radix paeoniae rubra, 4.5 parts of Radix Glycyrrhizae, 7.5 parts of Radix Angelicae Sinensis, 4.5 parts of Rhizoma Chuanxiong, 7.5 parts of Radix Rehmanniae, 7.5 parts of peach kernel, 25 parts of safflower, 12.5 parts of radix achyranthis bidentatae, 1.25 parts of Verbena officinalis, 12.5 parts of motherwort, rhizoma imperatae 7.5 Part.
4. a kind of Chinese medicine for treating chronic kidney according to claim 1 and its oral preparation, which is characterized in that the peach Benevolence uses powdered peach kernel powder.
5. a kind of Chinese medicine for treating chronic kidney according to claim 1 and its oral preparation, which is characterized in that described red Flower, motherwort, rhizoma imperatae, radix achyranthis bidentatae and peach kernel weight ratio be 6-10:5:3:5:3.
6. a kind of preparation method for the oral preparation of Chinese traditional medicinal for treating chronic kidney, which comprises the following steps:
S1 after removing the peel peach kernel, is put into grinding device, is fully ground into fine powder, spare;
S2 is clear by safflower, radix achyranthis bidentatae, radix bupleuri, the dried immature fruit of citron orange, radix paeoniae rubra, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae, Verbena officinalis, motherwort, rhizoma imperatae It after wash clean, adds water to cook three times, 3 hours for the first time, second 2 hours, third time 1 hour obtains decocting mixed extract;
Extracting solution Chinese medicine slag is filtered behind the cooling and standings of decoction mixed extract 12 hours in S2, obtains concentrate by S3;
S4, it is in confection that preparation in the concentrate in S3, which is added, in the peach kernel powder in S1, obtains medicinal preparation for oral administration.
CN201811431060.3A 2018-11-28 2018-11-28 A kind of Chinese medicine that treating chronic kidney and its oral preparation Pending CN109528938A (en)

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CN103977106A (en) * 2014-05-15 2014-08-13 山东大学 Traditional Chinese medicine preparation for treating nephrotic syndrome and preparation method thereof

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CN1524567A (en) * 2003-09-12 2004-09-01 北京同仁堂医药科技发展有限公司 Xuefu Zhuyu soft capsule and its preparation method
CN102048975A (en) * 2011-01-10 2011-05-11 南方医科大学 Traditional Chinese medicine composition for treating nephritic hematuria
CN103977106A (en) * 2014-05-15 2014-08-13 山东大学 Traditional Chinese medicine preparation for treating nephrotic syndrome and preparation method thereof

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Application publication date: 20190329