CN109528900A - A kind of Chinese medicine composition that treating Granulomatous mastitis, Chinese materia medica preparation and preparation method thereof - Google Patents
A kind of Chinese medicine composition that treating Granulomatous mastitis, Chinese materia medica preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions for treating Granulomatous mastitis, Chinese materia medica preparation and preparation method thereof, which comprises the following components in parts by weight: 15-26 parts of Radix Paeoniae Alba, 12-18 parts of Fructus Aurantii, 5-12 parts of rhizoma cyperi, 4-12 parts of hawthorn, 8-14 parts of corydalis tuber, 16-25 parts of cordate houttuynia, 5-10 parts of raw rhubarb, 10-15 parts of Radix Astragali, 12-25 parts of dandelion, 8-14 parts of olibanum, 6-14 parts of myrrh, 6-12 parts of Fructus Liquidambaris, 3-9 parts of schizonepeta, 5-13 parts of Herba Epimedii, 5-13 parts of the fruit of glossy privet, 15-30 parts of motherwort, 6-12 parts of Radix Polygalae and 3-9 parts of Radix Notoginseng.The dosage form of Chinese materia medica preparation includes oral solution, capsule and granule.The Chinese materia medica preparation can effectively solve the problem of that existing drug existing therapeutic effect when treating Granulomatous mastitis is poor, treatment time long Chinese materia medica preparation is easy recurrence after can also solving Granulomatous mastitis operation.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of Chinese traditional medicine composition for treating Granulomatous mastitis
Object, Chinese materia medica preparation and preparation method thereof.
Background technique
Granulomatous mastitis is confined to lobule of mammary gland using non-caseous necrosis and forms granuloma as main feature.Granulation
Swollen property mazoitis category Chinese medicine " galactorrhea ", " acute mastitis " scope.
The Granulomatous mastitis interpretation of the cause, onset and process of an illness is solidifying for stagnation of liver-QI with deficiency of the spleen phlegm.Galactosis is adjusted in nipple category Liver Channel, main catharsis.Liver
Obstruction of the circulation of vital energy knot causes qi-blood-body fluid dysfunction of the spleen in transportation and transformation and resolving sputum ties at wet, life in phlegm wet and forms lump in breast in newborn network.The long Yu Erhua of disease
Heat, heat toxin consume functional activities of the body fluid at purulence, and deficiency of qi and yin is delayed refractory.
Currently, the formula of the treatment proliferation of mammary gland, mazoitis, specifically includes that 1. Chinese medicines: there is JIAWEI XIAOYAOWAN, Xiaoyao San, small
Golden ball, Ru Pi Ling", newborn block disappear, and function is to activate blood circulation and disperse blood clots, is resolving hard lump, clearing heat and detoxicating.Be used in combination Xiaoyao San (ball) and
Xiaojin pill or 'rukuaixiao ' tablet, 3 times a day, to dredge strongly fragrant menstruation regulating, disappear knot analgesic, can obtain certain effect；2. vitamin drug, main
If B family vitamin, A family vitamin has vitamin A content in report cyclomastopathy blood samples of patients to significantly reduce, another party
Think that vitamin A can promote inactive peroxide androsterone and ketopregnene hormone to be changed into active androsterone and progesterone in face.
The two can inhibit reaction of the mammary gland to estradiol afterwards, therefore certain effect can be obtained with vitaminization.It is tieed up and is given birth to using B race
Element, high-protein diet and beneficial hepar carry out 1-3 months liver protecting therapies, to correct high estrogen syndrome, to analgesic dissipating bind
Also there is certain curative effect；3. non-sex hormones medicine.Idodine (potassium iodide or Dobell's solution): can reduce pain, improve symptom.
Because low dose of idodine can Stimulation of Pituitary Gland frontal lobe, generate luteotropic hormone, promote follicular cyst of ovary luteinization, thus it is female swash
Plain horizontal reduction, and restore the normal function of ovary；4. sex hormones medicine.Such medicine have emerald green ball ketone, progesterone, tamoxifen,
Smell Yin Ting, it is red that etc.；5. improving the adjuvant therapy medicaments of symptom.
But the therapeutic effect of drug pair and Granulomatous mastitis currently used for treatment mazoitis, the proliferation of mammary gland is not
Obviously.The basic method for treating Granulomatous mastitis is operative treatment, by removal of lesions of performing the operation, but performs the operation removal of lesions
Afterwards, it is easy to recur, bring secondary injury to patient.Therefore, developing one kind has treatment very well for Granulomatous mastitis
The drug of effect is particularly important.
Summary of the invention
For above-mentioned deficiency in the prior art, the present invention provides a kind of Chinese traditional medicine compositions for treating Granulomatous mastitis
Object, Chinese materia medica preparation and preparation method thereof, the Chinese materia medica preparation can effectively solve existing drug when treating Granulomatous mastitis
The problem that existing therapeutic effect is poor, treatment time is long, the Chinese materia medica preparation are easy after can also solving Granulomatous mastitis operation
The problem of recurrence.
To achieve the above object, the technical solution adopted by the present invention to solve the technical problems is:
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: 15-26 parts of Radix Paeoniae Alba,
12-18 parts of Fructus Aurantii, 5-12 parts of rhizoma cyperi, 4-12 parts of hawthorn, 8-14 parts of corydalis tuber, 16-25 parts of cordate houttuynia, 5-10 parts of raw rhubarb, Radix Astragali
10-15 parts, 12-25 parts of dandelion, 8-14 parts of olibanum, 6-14 parts of myrrh, 6-12 parts of Fructus Liquidambaris, 3-9 parts of schizonepeta, Herba Epimedii 5-13
Part, 5-13 parts of the fruit of glossy privet, 15-30 parts of motherwort, 6-12 parts of Radix Polygalae and 3-9 parts of Radix Notoginseng.
Further, it comprises the following components in parts by weight: 18-22 parts of Radix Paeoniae Alba, 12-14 parts of Fructus Aurantii, 5-8 parts of rhizoma cyperi, hawthorn
4-8 parts, 8-10 parts of corydalis tuber, 16-20 parts of cordate houttuynia, 5-7 parts of raw rhubarb, 13-15 parts of Radix Astragali, 12-18 parts of dandelion, olibanum 8-10
Part, 6-10 parts of myrrh, 6-10 parts of Fructus Liquidambaris, 7-9 parts of schizonepeta, 9-13 parts of Herba Epimedii, 5-9 parts of the fruit of glossy privet, 20-25 parts of motherwort,
7-10 parts and Radix Notoginseng 3-7 parts of Radix Polygalae.
Further, it comprises the following components in parts by weight: 18 parts of Radix Paeoniae Alba, 13 parts of Fructus Aurantii, 5 parts of rhizoma cyperi, 6 parts of hawthorn, corydalis tuber 8
Part, 20 parts of cordate houttuynia, 5 parts of raw rhubarb, 15 parts of Radix Astragali, 17 parts of dandelion, 10 parts of olibanum, 10 parts of myrrh, 10 parts of Fructus Liquidambaris, schizonepeta
9 parts, 12 parts of Herba Epimedii, 9 parts of the fruit of glossy privet, 25 parts of motherwort, 10 parts of Radix Polygalae and 4 parts of Radix Notoginseng.
A kind of Chinese materia medica preparation for treating Granulomatous mastitis, including above-mentioned Chinese medicine composition and auxiliary material.
Further, auxiliary material is sucrose, dextrin and starch.
Further, Chinese materia medica preparation dosage form is oral solution, granule and capsule.
The preparation method of the Chinese materia medica preparation of above-mentioned treatment Granulomatous mastitis, comprising the following steps: (1) take Radix Paeoniae Alba,
Fructus Aurantii, rhizoma cyperi, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, fruit of glossy privet Radix Polygalae and Radix Notoginseng are added in extractor, 3-8 are added thereto
The water of times medicinal material weight impregnates 2h, then in 80-100 DEG C of extractions 5-8h, then remaining medicinal material is added in extractor, continuation
1-2h is extracted, filtering obtains the first extracting solution and filter residue；
(2) ethyl alcohol of the 70-90% of 3-8 times of filter residue volume is added into the filter residue of step (1), continues at 60-80 DEG C
3-6h is extracted, filtering obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), extracting solution is concentrated under reduced pressure, be concentrated as dry leaching
The clear cream that cream or relative density are 1.10-1.25, it is spare；
(4) by the dry extract and dextrin and starch in step (3), granule or capsule is made；By clear cream and sucrose,
Oral solution is made.
Further, the water of 6 times of medicinal material weight is added in step (1) into extractor, impregnates 2h, is then mentioned in 100 DEG C
6h is taken, then remaining medicinal material is added in extractor, continues to extract 2h, filtering obtains the first extracting solution and filter residue；
Further, 90% ethyl alcohol of 5 times of filter residue volumes is added in step (2) into filter residue, continues to mention at 80 DEG C
4h is taken, filters, obtains the second extracting solution.
It is had the beneficial effect that caused by above scheme
1, Chinese medicine composition of the invention have dispersing stagnated hepatoqi, benefiting qi and nourishing blood, activating microcirculation and removing stasis medicinal, clearing heat and detoxicating, cooling blood and relieving pain,
The effect of anti-inflammation and sterilization and detumescence and apocenosis inherently improves the body of patient, improves the constitution of patient, and then realize
Cure and reduce the probability of recurrence；Chinese medicine composition of the invention also has cheap, and raw material is easy to get, and instant edible and takes
The advantage of band.
2, Radix Paeoniae Alba, rhizoma cyperi, hawthorn and the equal return liver warp of corydalis tuber in the present invention has calming the liver, soothing the liver, qi-regulating, analgesic and dissipates
The effect of the stasis of blood acts synergistically between each other, can enhance the function and effect of dispersing stagnated hepatoqi, inherently solves patient due to hepatic depression
The problem of lump, pain caused by tying；Olibanum and myrrh also have the function of analgesic therapy and blood-activating and qi-promoting, with Radix Paeoniae Alba, rhizoma cyperi and member
It acts synergistically recklessly, the feeling of pain of patient can be reduced, it is frightened to patient's bring to mitigate pain；Radix Notoginseng has dissipating stasis and stanching bleeding, detumescence
The effect of analgesic therapy, the therapeutic effect of above-mentioned medicinal material can be further enhanced by being added into we, reduce the feeling of pain of patient；
Cordate houttuynia, raw rhubarb, dandelion and the fruit of glossy privet have clearing heat and detoxicating, the effect of cool blood detumescence, between them mutually
Synergistic effect can improve the hot constitution of patient, and affected part is accelerated to restore；Cordate houttuynia, dandelion, Fructus Liquidambaris, motherwort and Radix Polygalae etc.
Medicinal material also has detumescence and apocenosis, accelerates the discharge of affected part running sore, promotes skin newborn；Meanwhile Radix Astragali, motherwort, cordate houttuynia and excessive
The sheep leaves of pulse plants also has the function of tonifying Qi, enhancing immunity of organisms, fundamentally improves patient's constitution, mammary gland affected part is accelerated to repair, drop
Low mammitis recurs probability；Chinese medicine composition in the present invention is an entirety, is acted synergistically between each other, overall co-ordination,
Achieve the purpose that treat Granulomatous mastitis.And Chinese medicine composition of the invention also has treatment plasma cell mastitis
It has certain effect.
Specific embodiment
Embodiment 1
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: 15 parts of Radix Paeoniae Alba, Fructus Aurantii
12 parts, 5 parts of rhizoma cyperi, 4 parts of hawthorn, 8 parts of corydalis tuber, 16 parts of cordate houttuynia, 5 parts of raw rhubarb, 10 parts of Radix Astragali, 12 parts of dandelion, olibanum 8
Part, 6 parts of myrrh, 6 parts of Fructus Liquidambaris, 3 parts of schizonepeta, 5 parts of Herba Epimedii, 5 parts of the fruit of glossy privet, 15 parts of motherwort, 6 parts of Radix Polygalae and 3 parts of Radix Notoginseng.
Chinese materia medica preparation comprising above-mentioned Chinese medicine composition, when dosage form is oral solution, comprising the following steps:
(1) Radix Paeoniae Alba, Fructus Aurantii, rhizoma cyperi, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, fruit of glossy privet Radix Polygalae and Radix Notoginseng are taken, is added and extracts
In tank, the water of 3 times of medicinal material weight is added thereto, impregnates 2h, then in 100 DEG C of extraction 5h, then proposes the addition of remaining medicinal material
It takes in tank, continues to extract 1h, filtering obtains the first extracting solution and filter residue；
(2) 70% ethyl alcohol of 3 times of filter residue volumes is added into the filter residue of step (1), continues to extract 3h, mistake at 60 DEG C
Filter, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), relative density is concentrated under reduced pressure into extracting solution
It is spare for 1.10 clear cream；
(4) to sucrose and water will be added in the clear cream of step (3), oral solution is made.
Embodiment 2
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: 26 parts of Radix Paeoniae Alba, Fructus Aurantii
18 parts, 12 parts of rhizoma cyperi, 12 parts of hawthorn, 14 parts of corydalis tuber, 25 parts of cordate houttuynia, 10 parts of raw rhubarb, 15 parts of Radix Astragali, 25 parts of dandelion, cream
Fragrant 14 parts, 14 parts of myrrh, 12 parts of Fructus Liquidambaris, 9 parts of schizonepeta, 13 parts of Herba Epimedii, 13 parts of the fruit of glossy privet, 30 parts of motherwort, 12 parts of Radix Polygalae
With 9 parts of Radix Notoginseng.
Chinese materia medica preparation comprising above-mentioned Chinese medicine composition, when dosage form is granule, comprising the following steps:
(1) Radix Paeoniae Alba, Fructus Aurantii, rhizoma cyperi, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, fruit of glossy privet Radix Polygalae and Radix Notoginseng are taken, is added and extracts
In tank, the water of 8 times of medicinal material weight is added thereto, impregnates 2h, then in 100 DEG C of extraction 8h, then proposes the addition of remaining medicinal material
It takes in tank, continues to extract 2h, filtering obtains the first extracting solution and filter residue；
(2) 90% ethyl alcohol of 8 times of filter residue volumes is added into the filter residue of step (1), continues to extract 6h, mistake at 80 DEG C
Filter, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), extracting solution be concentrated under reduced pressure as dry extract, it is standby
With；
(4) dry extract in step (3) is crushed, and dextrin and starch is added thereto, granule is made.
Embodiment 3
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: 18 parts of Radix Paeoniae Alba, Fructus Aurantii
12 parts, 5 parts of rhizoma cyperi, 4 parts of hawthorn, 8 parts of corydalis tuber, 16 parts of cordate houttuynia, 5 parts of raw rhubarb, 13 parts of Radix Astragali, 12 parts of dandelion, olibanum 8
Part, 6 parts of myrrh, 6 parts of Fructus Liquidambaris, 7 parts of schizonepeta, 9 parts of Herba Epimedii, 5 parts of the fruit of glossy privet, 20 parts of motherwort, 7 parts of Radix Polygalae and 5 parts of Radix Notoginseng.
Chinese materia medica preparation comprising above-mentioned Chinese medicine composition, when dosage form is capsule, comprising the following steps:
(1) Radix Paeoniae Alba, Fructus Aurantii, rhizoma cyperi, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, fruit of glossy privet Radix Polygalae and Radix Notoginseng are taken, is added and extracts
In tank, the water of 4 times of medicinal material weight is added thereto, impregnates 2h, then in 90 DEG C of extraction 7h, then remaining medicinal material is added and is extracted
In tank, continue to extract 2h, filtering obtains the first extracting solution and filter residue；
(2) 80% ethyl alcohol of 3 times of filter residue volumes is added into the filter residue of step (1), continues to extract 6h, mistake at 70 DEG C
Filter, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), by extracting solution be concentrated under reduced pressure for dry extract it is standby
With；
(4) dry extract in step (3) is crushed, and dextrin is added thereto, filled capsule, capsule is made.
Embodiment 4
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: 22 parts of Radix Paeoniae Alba, Fructus Aurantii
14 parts, 8 parts of rhizoma cyperi, 8 parts of hawthorn, 10 parts of corydalis tuber, 20 parts of cordate houttuynia, 7 parts of raw rhubarb, 15 parts of Radix Astragali, 18 parts of dandelion, olibanum 10
Part, 10 parts of myrrh, 10 parts of Fructus Liquidambaris, 9 parts of schizonepeta, 13 parts of Herba Epimedii, 9 parts of the fruit of glossy privet, 25 parts of motherwort, 10 parts of Radix Polygalae and Radix Notoginseng
7 parts.
Chinese materia medica preparation comprising above-mentioned Chinese medicine composition, when dosage form is granule, comprising the following steps:
(1) Radix Paeoniae Alba, Fructus Aurantii, rhizoma cyperi, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, fruit of glossy privet Radix Polygalae and Radix Notoginseng are taken, is added and extracts
In tank, the water of 7 times of medicinal material weight is added thereto, impregnates 2h, then in 90 DEG C of extraction 8h, then remaining medicinal material is added and is extracted
In tank, continue to extract 2h, filtering obtains the first extracting solution and filter residue；
(2) 90% ethyl alcohol of 7 times of filter residue volumes is added into the filter residue of step (1), continues to extract 6h, mistake at 80 DEG C
Filter, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), extracting solution be concentrated under reduced pressure as dry extract, it is standby
With；
(4) dry extract in step (3) is crushed, and dextrin and starch is added thereto, granule is made.
Embodiment 5
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: 18 parts of Radix Paeoniae Alba, Fructus Aurantii
13 parts, 5 parts of rhizoma cyperi, 6 parts of hawthorn, 8 parts of corydalis tuber, 20 parts of cordate houttuynia, 5 parts of raw rhubarb, 15 parts of Radix Astragali, 17 parts of dandelion, olibanum 10
Part, 10 parts of myrrh, 10 parts of Fructus Liquidambaris, 9 parts of schizonepeta, 12 parts of Herba Epimedii, 9 parts of the fruit of glossy privet, 25 parts of motherwort, 10 parts of Radix Polygalae and Radix Notoginseng
4 parts.
Chinese materia medica preparation comprising above-mentioned Chinese medicine composition, when dosage form is oral solution, comprising the following steps:
(1) Radix Paeoniae Alba, Fructus Aurantii, rhizoma cyperi, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, the fruit of glossy privet and Radix Polygalae are taken, extractor is added
It is interior, the water of 6 times of medicinal material weight is added thereto, impregnates 2h, then in 100 DEG C of extraction 6h, then remaining medicinal material is added and is extracted
In tank, continue to extract 2h, filtering obtains the first extracting solution and filter residue；
(2) 90% ethyl alcohol of 5 times of filter residue volumes is added into the filter residue of step (1), continues to extract 4h, mistake at 80 DEG C
Filter, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), relative density is concentrated under reduced pressure into extracting solution
It is spare for 1.10 clear cream；
(4) to sucrose and water will be added in the clear cream of step (3), oral solution is made.
Comparative example 1
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: 13 parts of Fructus Aurantii, hawthorn
6 parts, 8 parts of corydalis tuber, 5 parts of raw rhubarb, 15 parts of Radix Astragali, 17 parts of dandelion, 10 parts of olibanum, 10 parts of myrrh, 10 parts of Fructus Liquidambaris, schizonepeta 9
Part, 12 parts of Herba Epimedii, 9 parts of the fruit of glossy privet and 10 parts of Radix Polygalae.
Chinese materia medica preparation comprising above-mentioned Chinese medicine composition, when dosage form is oral solution, comprising the following steps:
(1) take Fructus Aurantii, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, the fruit of glossy privet and Radix Polygalae, be added in extractor, thereto plus
Enter the water of 6 times of medicinal material weight, impregnate 2h, then in 100 DEG C of extraction 6h, then remaining medicinal material is added in extractor, continues to mention
2h is taken, filters, obtains the first extracting solution and filter residue；
(2) 90% ethyl alcohol of 5 times of filter residue volumes is added into the filter residue of step (1), continues to extract 4h, mistake at 80 DEG C
Filter, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), relative density is concentrated under reduced pressure into extracting solution
It is spare for 1.10 clear cream；
(4) to sucrose and water will be added in the clear cream of step (3), oral solution is made.
Comparative example 2
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: including following weight
The component of part: 18 parts of Radix Paeoniae Alba, 5 parts of rhizoma cyperi, 8 parts of corydalis tuber, 20 parts of cordate houttuynia, 5 parts of raw rhubarb, 15 parts of Radix Astragali, 10 parts of olibanum, myrrh
10 parts, 9 parts of schizonepeta, 12 parts of Herba Epimedii, 9 parts of the fruit of glossy privet, 25 parts of motherwort, 10 parts of Radix Polygalae and 4 parts of Radix Notoginseng.
Chinese materia medica preparation comprising above-mentioned Chinese medicine composition, when dosage form is oral solution, comprising the following steps:
(1) Radix Paeoniae Alba, rhizoma cyperi, corydalis tuber, raw rhubarb, the fruit of glossy privet, Radix Polygalae and Radix Notoginseng are taken, is added in extractor, 6 is added thereto
The water of times medicinal material weight impregnates 2h, then in 100 DEG C of extractions 6h, then by remaining medicinal material addition extractor, continues to extract
2h, filtering, obtains the first extracting solution and filter residue；
(2) 90% ethyl alcohol of 5 times of filter residue volumes is added into the filter residue of step (1), continues to extract 4h, mistake at 80 DEG C
Filter, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), relative density is concentrated under reduced pressure into extracting solution
It is spare for 1.10 clear cream；
(4) to sucrose and water will be added in the clear cream of step (3), oral solution is made.
Comparative example 3
A kind of Chinese medicine composition for treating Granulomatous mastitis, comprises the following components in parts by weight: 18 parts of Radix Paeoniae Alba, Fructus Aurantii
13 parts, 5 parts of rhizoma cyperi, 6 parts of hawthorn, 8 parts of corydalis tuber, 20 parts of cordate houttuynia, 5 parts of raw rhubarb, 15 parts of Radix Astragali, 17 parts of dandelion, olibanum 10
Part, 10 parts of myrrh, 10 parts of Fructus Liquidambaris, 9 parts of schizonepeta, 12 parts of Herba Epimedii, 9 parts of the fruit of glossy privet, 25 parts of motherwort, 10 parts of Radix Polygalae and Radix Notoginseng
4 parts.
Chinese materia medica preparation comprising above-mentioned Chinese medicine composition, when dosage form is oral solution, comprising the following steps:
(1) Radix Paeoniae Alba, Fructus Aurantii, rhizoma cyperi, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, the fruit of glossy privet, Radix Polygalae and Radix Notoginseng are taken, addition mentions
It takes in tank, the water of 6 times of medicinal material weight is added thereto, impregnate 2h, then in 70 DEG C of extraction 6h, then propose the addition of remaining medicinal material
It takes in tank, continues to extract 2h, filtering obtains the first extracting solution and filter residue；
(2) 60% ethyl alcohol of 5 times of filter residue volumes is added into the filter residue of step (1), continues to extract 4h, mistake at 60 DEG C
Filter, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), relative density is concentrated under reduced pressure into extracting solution
It is spare for 1.10 clear cream；
(4) to sucrose and water will be added in the clear cream of step (3), oral solution is made.
Test example
1, mouse experiment
(1) the anti-inflammatory effect experiment of Chinese medicine composition paraxylene induced mice auricle edema
By animal subject female healthy mice 90,9 groups are randomly divided by weight, it may be assumed that embodiment 1-5 group, comparative example 1-3
Group and physiological saline group, every group 10.
Medication and processing: by above-mentioned dosage to animal subject gastric infusion, successive administration 10 days, 1 time a day, volume
It is 20ml/kg；1 hour after the last administration, animal subject was anesthetized with ether, and two sides is coated with proinflammatory agent diformazan before and after auris dextra
Benzene, every mouse 0.02ml, left ear is with no treatment.After 4 hours, animal is put to death, cuts ears 8mm diameter punch
Round auricle, electronic balance weighing are laid at same position respectively.
Swelling is according to the following formula: swelling=auris dextra sheet weight-left auricle weight, continuous data using mean ±
Standard deviation indicates that comparison among groups use one-way analysis of variance, the results are shown in Table 1.
Table 1: the anti-inflammatory effect experimental result of mouse paraxylene induced mice auricle edema
| Size of animal | Dosage (g/kg) | Swelling | |
| Embodiment 1 | 10 | 20ml/kg | 4.51±1.2 |
| Embodiment 2 | 10 | 20ml/kg | 4.34±1.1 |
| Embodiment 3 | 10 | 20ml/kg | 4.31±1.3 |
| Embodiment 4 | 10 | 20ml/kg | 4.29±1.2 |
| Embodiment 5 | 10 | 20ml/kg | 4.11±1.2 |
| Comparative example 1 | 10 | 20ml/kg | 6.21±1.1 |
| Comparative example 2 | 10 | 20ml/kg | 6.14±1.2 |
| Comparative example 3 | 10 | 20ml/kg | 6.10±1.3 |
| Physiological saline group | 10 | 20ml/kg | 7.92±1.3 |
It is learnt by table 1, the Chinese materia medica preparation of embodiment 1-5 and comparative example 1-3 are to mice auricle swelling compared with physiological saline
It significantly inhibits, the inhibiting effect of embodiment 1-5 is strong compared with comparative example 1-3, and especially the inhibiting effect of embodiment 5 is most
By force.
(2) influence experiment of the Chinese medicine composition to mice pain writhing response
Mouse 90 are taken, random point 9 groups, i.e. blank control group (physiological saline 0.2ml/10g), embodiment 1-5 group and right
Ratio 1-3 group, each group 10, half male and half female.By the above each group mouse by only pressing dosage gastric infusion 3 days of 2.0g/kg, administration
Volume is 20ml/kg, 2 times/day, is injected intravenously within 30 minutes after last gastric infusion 0.6% glacial acetic acid 0.2ml/ again only.With
It is pain reaction indicator that writhing, which occurs, in upper mouse.Each group is by only mouse writhing number in record 10 minutes.It examines, the results are shown in Table through t
2。
Table 2: mouse is to pain Body writhing test result
| Size of animal (only) | Pain writhing response number (10min) | |
| Embodiment 1 | 10 | 17.3±5.6 |
| Embodiment 2 | 10 | 17.8±5.1 |
| Embodiment 3 | 10 | 16.4±4.9 |
| Embodiment 4 | 10 | 14.6±5.2 |
| Embodiment 5 | 10 | 11.6±3.4 |
| Comparative example 1 | 10 | 19.5±6.2 |
| Comparative example 2 | 10 | 21.3±6.5 |
| Comparative example 3 | 10 | 24.4±5.2 |
| Blank control group | 10 | 28.4±6.5 |
It is learnt by table 2, the Chinese materia medica preparation of embodiment 1-5 and comparative example 1-3 cause mice pain writhing response to glacial acetic acid
Number has apparent antagonism compared with physiological saline, and the antagonism of embodiment 1-5 is strong compared with comparative example 1-3, especially
The antagonism of embodiment 5 is most strong.
2, the experiment of Granulomatous mastitis is treated
Experimental material:
Select mazoitis patient 200 to hospital, the age 24~42 years old, multipara 121；2~7d of the course of disease, clinical table
Existing lump in breast, distending pain, quality is harder, tenderness is obvious, and nipple occludes or flows out yellow and purulent secretion, or with ipsilateral armpit
Nest enlargement of lymph nodes.It is randomly divided into control group and each 100 for the treatment of group.Two groups of patient ages, final recognition, the course of disease, clinical manifestations
Etc. equal no difference of science of statistics.
Diagnostic criteria:
Diagnostic criteria: (1) patient is mostly Women in menopause or multipara；(2) from the beginning of there is lump in breast, morbidity is prominent
So or lump increases suddenly, and rubefaction forms microabscess after a few days, and fester is few after ulceration, long disunion；(3) patient is ipsilateral
The enlargement of axillary lymph knot is with pain.
Treatment method:
Treatment group: giving 5 oral solution of the embodiment of the present invention, and 3 times a day, each 10ml, 10 days as a treatment course treat 3-
5 courses for the treatment of.
Control group: xiaojin pill, lot number 160301, manufacturer are given are as follows: nine Zhi Tangjin ancient cooking vessel pharmaceutcal corporation, Ltds；Daily
2 times, each 1.2-3g, 10 days as one therapeutic course treats the 3-5 course for the treatment of.
Efficacy determination:
(1) fully recover: mammary swelling, pain, lump tenderness, surface is red and swollen, and the symptoms such as fever totally disappeared mistake.
(2) improve: high fever has been moved back, and galactapostema softening, side axillary gland becomes smaller.
(3) invalid: symptom is same to treat preceding no significant difference.
Treatment results:
After two groups are treated 3 courses for the treatment of respectively, statistical result is referring to table 3.Track record is carried out 2 years to this 200 patients, note
The recurrence of Granulomatous mastitis is recorded, concrete outcome is shown in Table 4.
Table 3: treatment results of the Chinese materia medica preparation of embodiment 5 for Granulomatous mastitis
| Group | It cures | It improves | In vain | It is efficient |
| Treatment group | 94 | 2 | 4 | 96% |
| Control group | 40 | 5 | 55 | 45% |
It is learnt by table 3, the Chinese materia medica preparation of embodiment 5 has good therapeutic effect for Granulomatous mastitis, controls
More rate is up to 96%.
Table 4: the recurrence statistical result after treatment 2 years
| Group | Treatment | It does not recur | Recurrence | Recurrence rate |
| Treatment group | 100 | 100 | 0 | 0 |
| Control group | 100 | 86 | 14 | 14% |
It is learnt by table 4, after being treated using the drug of embodiment 5 in the present invention, the probability recurred in two years is 0, and
After being treated using xiaojin pill, the probability of recurrence is 14%, it is known that, granulomatous cream can be effectively suppressed in the preparation in the present invention
The recurrence of adenositis.
4, the experiment of plasma cell mastitis is treated
Experimental material:
Select mazoitis patient 200 to hospital, the age 24~42 years old, clinical manifestation mammary areola scale inner skin is red, it is swollen,
Fever, tenderness, the accessible enlargement in oxter lymph node and have tenderness, whole body can have shiver with cold, high fever etc. performance.It is formed around mammary areola
Lump, mass edge is unclear, and like abscess of breast, Tumor size is different, and pus etc. can often be extracted out by puncturing swollen object.It is randomly divided into control
Group and each 100 for the treatment of group.The equal no difference of science of statistics such as two groups of patient ages, the course of disease, clinical manifestations.
Diagnostic criteria:
Treatment method:
Treatment group: giving 5 oral solution of the embodiment of the present invention, and 3 times a day, each 10ml, 10 days as a treatment course treat 3-
5 courses for the treatment of.
Control group: Ru Repair-in capsule for eliminating, lot number 170301, manufacturer are given are as follows: Guangdong Leiyunshang Pharmaceutical Co., Ltd.；
3 times a day, 5-6 each, 10 days as one therapeutic course treats the 3-5 course for the treatment of.
Efficacy determination:
(1) fully recover: mammary areola scale inner skin is red, swollen, fever, tenderness, the accessible enlargement in oxter lymph node and have tenderness,
Abscess of breast, whole body can have the symptoms such as shiver with cold, high fever to totally disappeared mistake.
(2) improve: high fever has been moved back, and galactapostema softening, side axillary gland becomes smaller.
(3) invalid: symptom is same to treat preceding no significant difference.
Treatment results:
After two groups are treated 3 courses for the treatment of respectively, statistical result is referring to table 5.Track record is carried out 2 years to this 200 patients, note
The recurrence of Granulomatous mastitis is recorded, concrete outcome is shown in Table 6.
Table 5: treatment results of the Chinese materia medica preparation of embodiment 5 for plasma cell mastitis
| Group | It cures | It improves | In vain | It is efficient |
| Treatment group | 90 | 5 | 5 | 95% |
| Control group | 37 | 3 | 60 | 40% |
It is learnt by table 5, the Chinese materia medica preparation of embodiment 5 has good therapeutic effect for Granulomatous mastitis, controls
More rate is up to 95%.
Table 6: the recurrence statistical result after treatment 2 years
| Group | Treatment | It does not recur | Recurrence | Recurrence rate |
| Treatment group | 100 | 100 | 0 | 0 |
| Control group | 100 | 90 | 10 | 10% |
It is learnt by table 6, after being treated using the drug of embodiment 5 in the present invention, the probability recurred in two years is 0, and
After being treated using xiaojin pill, the probability of recurrence is 10%, it is known that, plasmacytic cream can be effectively suppressed in the preparation in the present invention
The recurrence of adenositis.
Claims (9)
1. a kind of Chinese medicine composition for treating Granulomatous mastitis, which is characterized in that comprise the following components in parts by weight: Radix Paeoniae Alba
15-26 parts, 12-18 parts of Fructus Aurantii, 5-12 parts of rhizoma cyperi, 4-12 parts of hawthorn, 8-14 parts of corydalis tuber, 16-25 parts of cordate houttuynia, raw rhubarb 5-10
It is part, 10-15 parts of Radix Astragali, 12-25 parts of dandelion, 8-14 parts of olibanum, 6-14 parts of myrrh, 6-12 parts of Fructus Liquidambaris, 3-9 parts of schizonepeta, excessive
5-13 parts of the sheep leaves of pulse plants, 5-13 parts of the fruit of glossy privet, 15-30 parts of motherwort, 6-12 parts of Radix Polygalae and 3-9 parts of Radix Notoginseng.
2. the Chinese medicine composition for the treatment of Granulomatous mastitis as described in claim 1, which is characterized in that including following weight
The component of part: 18-22 parts of Radix Paeoniae Alba, 12-14 parts of Fructus Aurantii, 5-8 parts of rhizoma cyperi, 4-8 parts of hawthorn, 8-10 parts of corydalis tuber, cordate houttuynia 16-20
Part, 5-7 parts of raw rhubarb, 13-15 parts of Radix Astragali, 12-18 parts of dandelion, 8-10 parts of olibanum, 6-10 parts of myrrh, 6-10 parts of Fructus Liquidambaris,
7-9 parts of schizonepeta, 9-13 parts of Herba Epimedii, 5-9 parts of the fruit of glossy privet, 20-25 parts of motherwort, 7-10 parts of Radix Polygalae and 4-7 parts of Radix Notoginseng.
3. the Chinese medicine composition for the treatment of Granulomatous mastitis as claimed in claim 1 or 2, which is characterized in that including following
The component of parts by weight: 18 parts of Radix Paeoniae Alba, 13 parts of Fructus Aurantii, 5 parts of rhizoma cyperi, 6 parts of hawthorn, 8 parts of corydalis tuber, 20 parts of cordate houttuynia, 5 parts of raw rhubarb,
15 parts of Radix Astragali, 17 parts of dandelion, 10 parts of olibanum, 10 parts of myrrh, 10 parts of Fructus Liquidambaris, 9 parts of schizonepeta, 12 parts of Herba Epimedii, the fruit of glossy privet 9
Part, 25 parts of motherwort, 10 parts of Radix Polygalae and 4 parts of Radix Notoginseng.
4. a kind of Chinese materia medica preparation for treating Granulomatous mastitis, which is characterized in that described in any item including claim 1-2
Chinese medicine composition and auxiliary material.
5. the Chinese materia medica preparation for the treatment of Granulomatous mastitis according to claim 4, which is characterized in that the auxiliary material is sugarcane
At least one of sugar, dextrin and starch.
6. the Chinese materia medica preparation for the treatment of Granulomatous mastitis according to claim 5, which is characterized in that the agent of Chinese materia medica preparation
Type is oral solution, granule and capsule.
7. it is as claimed in claim 6 treatment Granulomatous mastitis Chinese materia medica preparation preparation method, which is characterized in that including with
Lower step: (1) taking Radix Paeoniae Alba, Fructus Aurantii, rhizoma cyperi, hawthorn, corydalis tuber, raw rhubarb, Fructus Liquidambaris, the fruit of glossy privet, Radix Polygalae and Radix Notoginseng, is added and extracts
In tank, the water of 3-8 times of medicinal material weight is added thereto, 2h is impregnated, then in 80-100 DEG C of extraction 5-8h, then by remaining medicinal material
It is added in extractor, continues to extract 1-2h, filtering obtains the first extracting solution and filter residue；
(2) ethyl alcohol of the 70-90% of 3-8 times of filter residue volume is added into the filter residue of step (1), continues to extract at 60-80 DEG C
3-6h, filtering, obtains the second extracting solution；
(3) merge extracting solution obtained in step (1) and step (2), extracting solution be concentrated under reduced pressure, be concentrated as dry extract or
Person's relative density is the clear cream of 1.10-1.25, spare；
(4) by the dry extract and dextrin and starch in step (3), granule or capsule is made；By clear cream and sucrose, it is made
Oral solution.
8. the preparation method of the Chinese materia medica preparation for the treatment of Granulomatous mastitis as claimed in claim 7, which is characterized in that step
(1) water of 6 times of medicinal material weight is added in into extractor, impregnates 2h and then adds remaining medicinal material then in 100 DEG C of extraction 6h
Enter in extractor, continues to extract 2h, filtering obtains the first extracting solution and filter residue.
9. the preparation method of the Chinese materia medica preparation for the treatment of Granulomatous mastitis as claimed in claim 7, which is characterized in that step
(2) 90% ethyl alcohol of 5 times of filter residue volumes is added in into filter residue, continues to extract 4h at 80 DEG C, filtering obtains the second extraction
Liquid.
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| CN112220899A (en) * | 2020-12-01 | 2021-01-15 | 云南苗心康生物科技有限公司 | Traditional Chinese medicine composition for breast health care and breast collateral dredging and preparation method thereof |
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| CN112220899A (en) * | 2020-12-01 | 2021-01-15 | 云南苗心康生物科技有限公司 | Traditional Chinese medicine composition for breast health care and breast collateral dredging and preparation method thereof |
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