CN109528882A - A kind of formula and preparation method thereof for nerve contact dermatitis medicament - Google Patents
A kind of formula and preparation method thereof for nerve contact dermatitis medicament Download PDFInfo
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Abstract
The invention discloses a kind of formula for nerve contact dermatitis medicament, the constituent of the reagent combination includes purging croton leaf, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, polygonum cuspidate, Chinese honeylocust seed, safflower, indigo naturalis, duckweed and the fruit of summer cypress；Wherein, the parts by weight of the active ingredient raw materials of the reagent combination are formed are as follows: 30-80 parts of purging croton leaf, 30-80 parts of CORTEX AILANTHI, 30-100 parts of cacumen biotae, 30-100 parts of cortex dictamni, 30-100 parts of corter pseudolaricis, 30-120 parts of kuh-seng, 30-150 parts of raw rhubarb, 30-100 parts of polygonum cuspidate, 30-100 parts of Chinese honeylocust seed, 30-100 parts of safflower, 10-50 parts of indigo naturalis, -100 parts of duckweed, 30-100 parts of the fruit of summer cypress.
Description
Technical field
Prepare related fields the present invention relates to Chinese medicine, specially a kind of formula for nerve contact dermatitis medicament and
Preparation method.
Background technique
" psoriasis " of neurodermatitis and Chinese medicine, " neurodermatitis " etc. are similar.Because rheumatism accumulates skin, caused by stagnation of meridian-QI.
It is apt to occur in neck, four limbs, waist sacrum, plump with symmetry pachylosis, violent itch is the skin disease mainly showed, nerve
Dermatitis is also known as lichen simplex chronicus, this disease is the chronic dermatosis that feature is turned to paroxysmal pruitus and skin moss,
For common multiple cutaneous disease, it to be more common in young and adult, children and does not fall ill generally, summer is multiple or seasonal unobvious,
Preferably to be treated with the exterior-applied article of no hormone, neurodermatitis is a kind of skin function obstacle disease, there is apparent skin lesion,
It mostly occurs in nape or its two sides, fossa cubitalis, popliteal nest, forearm, thigh, shank and lumbosacral region etc..Often occur in flakes, is in triangle
Shape or polygonal flat-top papule, pachyderma, skin ridge protrusion, sulci of skin are deepened, and moss is similar to.Often in light red or filbert, play
Strong itch is its main symptom.As whole skin has more apparent impairer, also referred to as diffused neurodermatitis.Chinese medicine is recognized
Are as follows: within this disease is main because based on, since mind is bothered, inernal injuries caused by seven emotions, interior raw internal heat and cause.It is redder from the beginning of fash, itch compared with
Play, because of heart governing blood and vessels, heart-fire hyperactivity, volt generates blood-head, blood hot air wind producing, wind Sheng Ze is dry, belongs to blood-head wind-dryness in ying blood.It is sick long,
Skin lesion is plump, and unity and coherence in writing is big and heavy, is in mossization person, because of prolonged illness blood trouble, wind Sheng Ze is dry for this, belongs to blood-deficiency and wind-dry.
The following are two kinds of classification: local neurodermatitis: 90% or more is apt to occur in neck, secondly for elbow, sacrum, eyelid,
Popliteal nest etc. feels local itch first, after occur the grain grain of cluster to grain of rice color of the leather normal greatly or it is filbert, pale red is polygonal
The flat papule of shape, slightly has gloss, a small amount of chaff shape scales of skin that peel off is covered, and then papule merges into each other in flakes, because of often scratching stimulation skin of itching
The cumulative thickness of skin, forms lichenification, and boundary understands that skin lesions circumferece common scratch in affected part has scab to be formed.Eczema skin
Scorching: skin lesion performance is similar to local neurodermatitis but widely distributed, involves head, four limbs trunk etc., paroxysmal itching,
Especially be very, to influence to sleep with night, the course of disease is chronic, easy recurrent exerbation, due to often scratch can secondary eczema sample change or secondary
Epifolliculitis, dothienesis etc. occur for infection.
Currently, treatment neurodermatitis with take Western medicine or smear hormone ointment based on, oral western medicine on the one hand cannot root
It removes, the problem of another aspect side effect is big, and that there are the courses of disease is long for Chinese medicine treatment, weak curative effect.It therefore, can be effective with regard to how to find one kind
Thoroughly treat the drug of above-mentioned neurodermatitis disease, and can be effectively ensured cure restore after it is uneasy to recur, be we at present
Problem in urgent need to solve.
Summary of the invention
The purpose of the present invention is to provide a kind of formula and preparation method thereof for nerve contact dermatitis medicament, with
Solve the problems mentioned above in the background art.
To achieve the above object, the invention provides the following technical scheme:
A kind of formula for nerve contact dermatitis medicament, the constituent of the reagent combination include purging croton leaf, CORTEX AILANTHI,
Cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, polygonum cuspidate, Chinese honeylocust seed, safflower, indigo naturalis, duckweed and the fruit of summer cypress；Wherein, it forms
The parts by weight of the active ingredient raw materials of the reagent combination are as follows: 30-80 parts of purging croton leaf, 30-80 parts of CORTEX AILANTHI, cacumen biotae 30-
100 parts, 30-100 parts of cortex dictamni, 30-100 parts of corter pseudolaricis, 30-120 parts of kuh-seng, 30-150 parts of raw rhubarb, 30-100 parts of polygonum cuspidate,
30-100 parts of Chinese honeylocust seed, 30-100 parts of safflower, 10-50 parts of indigo naturalis, 30-100 parts of duckweed, 30-100 parts of the fruit of summer cypress.
As a preferred technical solution of the present invention, the parts by weight of the active ingredient raw materials of the reagent combination are formed
Are as follows: 50 parts of purging croton leaf, 50 parts of CORTEX AILANTHI, 70 parts of cacumen biotae, 70 parts of cortex dictamni, 70 parts of corter pseudolaricis, 90 parts of kuh-seng, raw rhubarb 120
Part, 70 parts of polygonum cuspidate, 70 parts of Chinese honeylocust seed, 70 parts of safflower, 40 parts of indigo naturalis, 70 parts of duckweed, 70 parts of the fruit of summer cypress.
As a preferred technical solution of the present invention, the parts by weight of the active ingredient raw materials of the reagent combination are formed
Are as follows: 55 parts of purging croton leaf, 55 parts of CORTEX AILANTHI, 65 parts of cacumen biotae, 65 parts of cortex dictamni, 65 parts of corter pseudolaricis, 75 parts of kuh-seng, raw rhubarb 90
Part, 65 parts of polygonum cuspidate, 65 parts of Chinese honeylocust seed, 65 parts of safflower, 30 parts of indigo naturalis, 65 parts of duckweed, 65 parts of the fruit of summer cypress.
As a preferred technical solution of the present invention, the parts by weight of the active ingredient raw materials of the reagent combination are formed
Are as follows: 40 parts of purging croton leaf, 40 parts of CORTEX AILANTHI, 50 parts of cacumen biotae, 50 parts of cortex dictamni, 50 parts of corter pseudolaricis, 60 parts of kuh-seng, raw rhubarb 75
Part, 50 parts of polygonum cuspidate, 50 parts of Chinese honeylocust seed, 50 parts of safflower, 25 parts of indigo naturalis, 50 parts of duckweed, 50 parts of the fruit of summer cypress.
As a preferred technical solution of the present invention, the parts by weight of the active ingredient raw materials of the reagent combination are formed
Are as follows: 60 parts of purging croton leaf, 60 parts of CORTEX AILANTHI, 70 parts of cacumen biotae, 70 parts of cortex dictamni, 70 parts of corter pseudolaricis, 100 parts of kuh-seng, raw rhubarb 110
Part, 70 parts of polygonum cuspidate, 70 parts of Chinese honeylocust seed, 70 parts of safflower, 35 parts of indigo naturalis, 70 parts of duckweed, 70 parts of the fruit of summer cypress.
The present invention also provides the preparation method of above-mentioned nerve contact dermatitis medicament, including the following steps:
S1, purging croton leaf, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, polygonum cuspidate, Chinese honey locust are taken in parts by weight
Son, safflower, indigo naturalis, duckweed and the fruit of summer cypress except dust is cleaned, and separate vacuum drying, spare；
S2, purging croton leaf in S1 is taken, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis pulverizes and sieves to obtain each crushed material respectively, then
Obtained each crushed material is extracted respectively with 50wt% ethanol water, extraction solid-liquid ratio is 1:4-1:9, and extraction time is
1-4h, extraction temperature are 45-65 DEG C, are centrifugated after extraction, supernatant liquor is concentrated again, are respectively purging croton leaf after concentration
50wt% ethyl alcohol water extract, CORTEX AILANTHI 50wt% ethyl alcohol water extract, cacumen biotae 50wt% ethyl alcohol water extract, cortex dictamni 50wt%
Ethyl alcohol water extract and corter pseudolaricis 50wt% ethyl alcohol water extract, it is spare；
S3, take kuh-seng in S1, with 75% ethyl alcohol heating and refluxing extraction 3 times, extraction time first time be 2 hours, second and
The extraction time of third time is 1.5 hours, respectively obtains an extracting solution, secondary raffinate and extracting solution three times, will be primary
Extracting solution, secondary raffinate and three times extracting solution filtering after merge, after vacuum distillation recovered solvent, be freeze-dried to obtain kuh-seng leaching
Cream；
S4, by the kuh-seng medicinal extract in step S3, be placed in vacuum oven, be dried under vacuum under the conditions of temperature is not more than 62 DEG C
Moisture content is ground into kuh-seng fine powder less than 5%, spare；
S5, raw rhubarb in S1, polygonum cuspidate, Chinese honeylocust seed and safflower are taken, is mixed to get mixture after pulverizing and sieving, which is set
In sealing container, 2-3 times of the said mixture 75% ethyl alcohol Mi Gai measured is added, impregnates 5, daily stirring 4-5 times later, is inclined
Supernatant is taken, the 2-3 times of 75% ethyl alcohol Mi Gai measured is added in raw medicine matter, is impregnated 3 with method, inclines and take supernatant, and with first
Secondary obtained supernatant merges, and obtains mixing supernatant, stands 24 hours, spare；
S6, indigo naturalis in S1, duckweed and the fruit of summer cypress are taken, pulverizes and sieves to obtain each crushed material respectively, then stirred with dehydrated alcohol
Extraction is mixed, the time for stirring extraction is 2-5h, and the feed liquid weight ratio for stirring extraction is 1:6-1:10, and the temperature for stirring extraction is
40-50 DEG C, be centrifugated after extraction, obtained after supernatant is concentrated in vacuo indigo naturalis ethanol extract, duckweed ethanol extract and
Fruit of summer cypress ethanol extract；
S7, by purging croton leaf 50wt% ethyl alcohol water extract obtained in S2, CORTEX AILANTHI 50wt% ethyl alcohol water extract, cacumen biotae
50wt% ethyl alcohol water extract, cortex dictamni 50wt% ethyl alcohol water extract and corter pseudolaricis 50wt% ethyl alcohol water extract, obtained in S4
Kuh-seng fine powder, with indigo naturalis ethanol extract, duckweed ethanol extract obtained in mixing supernatant obtained in S5 and S6 and
The mixing of fruit of summer cypress ethanol extract after concussion shakes up, is placed in the shady place that temperature is 0 ~ 28 DEG C and ferments 30 ~ 35 days, form tincture
For use.
Compared with prior art, the beneficial effects of the present invention are: the present invention is a kind of to be used for nerve contact dermatitis medicament
Formula and preparation method thereof, by using purging croton leaf, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, tiger
Cane, Chinese honeylocust seed, safflower, indigo naturalis, duckweed and fruit of summer cypress support medicament are applied with, and skin Transdermal absorption effect is more preferable, is eliminated with reaching
The effect of lesion, has therapeutic effect good, and cure rate is high, and treatment cycle is short, and the advantages of elimination lesion.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
Embodiment 1: the present invention provides a kind of technical solution: a kind of formula for nerve contact dermatitis medicament, should
The constituent of reagent combination includes purging croton leaf, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, polygonum cuspidate, soap
Pod, safflower, indigo naturalis, duckweed and the fruit of summer cypress；Wherein, the parts by weight of the active ingredient raw materials of the reagent combination are formed are as follows:
30-80 parts of purging croton leaf, 30-80 parts of CORTEX AILANTHI, 30-100 parts of cacumen biotae, 30-100 parts of cortex dictamni, 30-100 parts of corter pseudolaricis, kuh-seng
30-120 parts, 30-150 parts of raw rhubarb, 30-100 parts of polygonum cuspidate, 30-100 parts of Chinese honeylocust seed, 30-100 parts of safflower, 10-50 parts of indigo naturalis,
30-100 parts of duckweed, 30-100 parts of the fruit of summer cypress.
Form the parts by weight of the active ingredient raw materials of the reagent combination are as follows: 50 parts of purging croton leaf, 50 parts of CORTEX AILANTHI, arbor-vitae
70 parts of leaf, 70 parts of cortex dictamni, 70 parts of corter pseudolaricis, 90 parts of kuh-seng, 120 parts of raw rhubarb, 70 parts of polygonum cuspidate, 70 parts of Chinese honeylocust seed, safflower 70
Part, 40 parts of indigo naturalis, 70 parts of duckweed, 70 parts of the fruit of summer cypress.
A kind of preparation method for nerve contact dermatitis medicament, including the following steps:
S1, purging croton leaf, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, polygonum cuspidate, Chinese honey locust are taken in parts by weight
Son, safflower, indigo naturalis, duckweed and the fruit of summer cypress except dust is cleaned, and separate vacuum drying, spare；
S2, purging croton leaf in S1 is taken, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis pulverizes and sieves to obtain each crushed material respectively, then
Obtained each crushed material is extracted respectively with 50wt% ethanol water, extraction solid-liquid ratio is 1:4-1:9, and extraction time is
1-4h, extraction temperature are 45-65 DEG C, are centrifugated after extraction, supernatant liquor is concentrated again, are respectively purging croton leaf after concentration
50wt% ethyl alcohol water extract, CORTEX AILANTHI 50wt% ethyl alcohol water extract, cacumen biotae 50wt% ethyl alcohol water extract, cortex dictamni 50wt%
Ethyl alcohol water extract and corter pseudolaricis 50wt% ethyl alcohol water extract, it is spare；
S3, take kuh-seng in S1, with 75% ethyl alcohol heating and refluxing extraction 3 times, extraction time first time be 2 hours, second and
The extraction time of third time is 1.5 hours, respectively obtains an extracting solution, secondary raffinate and extracting solution three times, will be primary
Extracting solution, secondary raffinate and three times extracting solution filtering after merge, after vacuum distillation recovered solvent, be freeze-dried to obtain kuh-seng leaching
Cream；
S4, by the kuh-seng medicinal extract in step S3, be placed in vacuum oven, be dried under vacuum under the conditions of temperature is not more than 62 DEG C
Moisture content is ground into kuh-seng fine powder less than 5%, spare；
S5, raw rhubarb in S1, polygonum cuspidate, Chinese honeylocust seed and safflower are taken, is mixed to get mixture after pulverizing and sieving, which is set
In sealing container, 2-3 times of the said mixture 75% ethyl alcohol Mi Gai measured is added, impregnates 5, daily stirring 4-5 times later, is inclined
Supernatant is taken, the 2-3 times of 75% ethyl alcohol Mi Gai measured is added in raw medicine matter, is impregnated 3 with method, inclines and take supernatant, and with first
Secondary obtained supernatant merges, and obtains mixing supernatant, stands 24 hours, spare；
S6, indigo naturalis in S1, duckweed and the fruit of summer cypress are taken, pulverizes and sieves to obtain each crushed material respectively, then stirred with dehydrated alcohol
Extraction is mixed, the time for stirring extraction is 2-5h, and the feed liquid weight ratio for stirring extraction is 1:6-1:10, and the temperature for stirring extraction is
40-50 DEG C, be centrifugated after extraction, obtained after supernatant is concentrated in vacuo indigo naturalis ethanol extract, duckweed ethanol extract and
Fruit of summer cypress ethanol extract；
S7, by purging croton leaf 50wt% ethyl alcohol water extract obtained in S2, CORTEX AILANTHI 50wt% ethyl alcohol water extract, cacumen biotae
50wt% ethyl alcohol water extract, cortex dictamni 50wt% ethyl alcohol water extract and corter pseudolaricis 50wt% ethyl alcohol water extract, obtained in S4
Kuh-seng fine powder, with indigo naturalis ethanol extract, duckweed ethanol extract obtained in mixing supernatant obtained in S5 and S6 and
The mixing of fruit of summer cypress ethanol extract after concussion shakes up, is placed in the shady place that temperature is 0 ~ 28 DEG C and ferments 30 ~ 35 days, form tincture
For use.
Embodiment 2: one of the present embodiment is used for the formula of nerve contact dermatitis medicament, forms the medicament and matches
The parts by weight of the active ingredient raw materials of side are as follows: 55 parts of purging croton leaf, 55 parts of CORTEX AILANTHI, 65 parts of cacumen biotae, 65 parts of cortex dictamni, the native rose of Sharon
65 parts of skin, 75 parts of kuh-seng, 90 parts of raw rhubarb, 65 parts of polygonum cuspidate, 65 parts of Chinese honeylocust seed, 65 parts of safflower, 30 parts of indigo naturalis, 65 parts of duckweed, ground
65 parts of skin.
A kind of preparation method in the present embodiment in preparation method for nerve contact dermatitis medicament and embodiment 1
It is identical, it is not repeating to introduce herein, detailed content refers to the preparation method in embodiment 1.
Embodiment 3: one of the present embodiment is used for the formula of nerve contact dermatitis medicament, forms the medicament and matches
The parts by weight of the active ingredient raw materials of side are as follows: 40 parts of purging croton leaf, 40 parts of CORTEX AILANTHI, 50 parts of cacumen biotae, 50 parts of cortex dictamni, the native rose of Sharon
50 parts of skin, 60 parts of kuh-seng, 75 parts of raw rhubarb, 50 parts of polygonum cuspidate, 50 parts of Chinese honeylocust seed, 50 parts of safflower, 25 parts of indigo naturalis, 50 parts of duckweed, ground
50 parts of skin.
A kind of preparation method in the present embodiment in preparation method for nerve contact dermatitis medicament and embodiment 1
It is identical, it is not repeating to introduce herein, detailed content refers to the preparation method in embodiment 1.
Embodiment 4: one of the present embodiment is used for the formula of nerve contact dermatitis medicament, forms the medicament and matches
The parts by weight of the active ingredient raw materials of side are as follows: 60 parts of purging croton leaf, 60 parts of CORTEX AILANTHI, 70 parts of cacumen biotae, 70 parts of cortex dictamni, the native rose of Sharon
70 parts of skin, 100 parts of kuh-seng, 110 parts of raw rhubarb, 70 parts of polygonum cuspidate, 70 parts of Chinese honeylocust seed, 70 parts of safflower, 35 parts of indigo naturalis, 70 parts of duckweed,
70 parts of the fruit of summer cypress.
A kind of preparation method in the present embodiment in preparation method for nerve contact dermatitis medicament and embodiment 1
It is identical, it is not repeating to introduce herein, detailed content refers to the preparation method in embodiment 1.
In conclusion a kind of formula and preparation method thereof for nerve contact dermatitis medicament of the present invention, by adopting
With purging croton leaf, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, polygonum cuspidate, Chinese honeylocust seed, safflower, indigo naturalis, duckweed and
The fruit of summer cypress supports medicament to be applied with, and skin Transdermal absorption effect is more preferable, to reach the effect of eliminating lesion, has therapeutic effect good,
Cure rate is high, and treatment cycle is short, and the advantages of elimination lesion.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of formula for nerve contact dermatitis medicament, which is characterized in that the constituent of the reagent combination includes
Purging croton leaf, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, polygonum cuspidate, Chinese honeylocust seed, safflower, indigo naturalis, duckweed and ground
Skin；Wherein, the parts by weight of the active ingredient raw materials of the reagent combination are formed are as follows: 30-80 parts of purging croton leaf, CORTEX AILANTHI 30-
80 parts, 30-100 parts of cacumen biotae, 30-100 parts of cortex dictamni, 30-100 parts of corter pseudolaricis, 30-120 parts of kuh-seng, raw rhubarb 30-150
Part, 30-100 parts of polygonum cuspidate, 30-100 parts of Chinese honeylocust seed, 30-100 parts of safflower, 10-50 parts of indigo naturalis, 30-100 parts of duckweed, the fruit of summer cypress
30-100 parts.
2. a kind of formula for nerve contact dermatitis medicament according to claim 1, which is characterized in that composition institute
State the parts by weight of the active ingredient raw materials of reagent combination are as follows: 50 parts of purging croton leaf, 50 parts of CORTEX AILANTHI, 70 parts of cacumen biotae, cortex dictamni
It 70 parts, 70 parts of corter pseudolaricis, 90 parts of kuh-seng, 120 parts of raw rhubarb, 70 parts of polygonum cuspidate, 70 parts of Chinese honeylocust seed, 70 parts of safflower, 40 parts of indigo naturalis, floats
70 parts of duckweed, 70 parts of the fruit of summer cypress.
3. a kind of formula for nerve contact dermatitis medicament according to claim 1, which is characterized in that composition institute
State the parts by weight of the active ingredient raw materials of reagent combination are as follows: 55 parts of purging croton leaf, 55 parts of CORTEX AILANTHI, 65 parts of cacumen biotae, cortex dictamni
It 65 parts, 65 parts of corter pseudolaricis, 75 parts of kuh-seng, 90 parts of raw rhubarb, 65 parts of polygonum cuspidate, 65 parts of Chinese honeylocust seed, 65 parts of safflower, 30 parts of indigo naturalis, floats
65 parts of duckweed, 65 parts of the fruit of summer cypress.
4. a kind of formula for nerve contact dermatitis medicament according to claim 1, which is characterized in that composition institute
State the parts by weight of the active ingredient raw materials of reagent combination are as follows: 40 parts of purging croton leaf, 40 parts of CORTEX AILANTHI, 50 parts of cacumen biotae, cortex dictamni
It 50 parts, 50 parts of corter pseudolaricis, 60 parts of kuh-seng, 75 parts of raw rhubarb, 50 parts of polygonum cuspidate, 50 parts of Chinese honeylocust seed, 50 parts of safflower, 25 parts of indigo naturalis, floats
50 parts of duckweed, 50 parts of the fruit of summer cypress.
5. a kind of formula for nerve contact dermatitis medicament according to claim 1, which is characterized in that composition institute
State the parts by weight of the active ingredient raw materials of reagent combination are as follows: 60 parts of purging croton leaf, 60 parts of CORTEX AILANTHI, 70 parts of cacumen biotae, cortex dictamni
70 parts, 70 parts of corter pseudolaricis, 100 parts of kuh-seng, 110 parts of raw rhubarb, 70 parts of polygonum cuspidate, 70 parts of Chinese honeylocust seed, 70 parts of safflower, 35 parts of indigo naturalis,
70 parts of duckweed, 70 parts of the fruit of summer cypress.
6. a kind of preparation method for nerve contact dermatitis medicament described in -5 according to claim 1, which is characterized in that
Including the following steps:
S1, purging croton leaf, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis, kuh-seng, raw rhubarb, polygonum cuspidate, Chinese honey locust are taken in parts by weight
Son, safflower, indigo naturalis, duckweed and the fruit of summer cypress except dust is cleaned, and separate vacuum drying, spare；
S2, purging croton leaf in S1 is taken, CORTEX AILANTHI, cacumen biotae, cortex dictamni, corter pseudolaricis pulverizes and sieves to obtain each crushed material respectively, then
Obtained each crushed material is extracted respectively with 50wt% ethanol water, extraction solid-liquid ratio is 1:4-1:9, and extraction time is
1-4h, extraction temperature are 45-65 DEG C, are centrifugated after extraction, supernatant liquor is concentrated again, are respectively purging croton leaf after concentration
50wt% ethyl alcohol water extract, CORTEX AILANTHI 50wt% ethyl alcohol water extract, cacumen biotae 50wt% ethyl alcohol water extract, cortex dictamni 50wt%
Ethyl alcohol water extract and corter pseudolaricis 50wt% ethyl alcohol water extract, it is spare；
S3, take kuh-seng in S1, with 75% ethyl alcohol heating and refluxing extraction 3 times, extraction time first time be 2 hours, second and
The extraction time of third time is 1.5 hours, respectively obtains an extracting solution, secondary raffinate and extracting solution three times, will be primary
Extracting solution, secondary raffinate and three times extracting solution filtering after merge, after vacuum distillation recovered solvent, be freeze-dried to obtain kuh-seng leaching
Cream；
S4, by the kuh-seng medicinal extract in step S3, be placed in vacuum oven, be dried under vacuum under the conditions of temperature is not more than 62 DEG C
Moisture content is ground into kuh-seng fine powder less than 5%, spare；
S5, raw rhubarb in S1, polygonum cuspidate, Chinese honeylocust seed and safflower are taken, is mixed to get mixture after pulverizing and sieving, which is set
In sealing container, 2-3 times of the said mixture 75% ethyl alcohol Mi Gai measured is added, impregnates 5, daily stirring 4-5 times later, is inclined
Supernatant is taken, the 2-3 times of 75% ethyl alcohol Mi Gai measured is added in raw medicine matter, is impregnated 3 with method, inclines and take supernatant, and with first
Secondary obtained supernatant merges, and obtains mixing supernatant, stands 24 hours, spare；
S6, indigo naturalis in S1, duckweed and the fruit of summer cypress are taken, pulverizes and sieves to obtain each crushed material respectively, then stirred with dehydrated alcohol
Extraction is mixed, the time for stirring extraction is 2-5h, and the feed liquid weight ratio for stirring extraction is 1:6-1:10, and the temperature for stirring extraction is
40-50 DEG C, be centrifugated after extraction, obtained after supernatant is concentrated in vacuo indigo naturalis ethanol extract, duckweed ethanol extract and
Fruit of summer cypress ethanol extract；
S7, by purging croton leaf 50wt% ethyl alcohol water extract obtained in S2, CORTEX AILANTHI 50wt% ethyl alcohol water extract, cacumen biotae
50wt% ethyl alcohol water extract, cortex dictamni 50wt% ethyl alcohol water extract and corter pseudolaricis 50wt% ethyl alcohol water extract, obtained in S4
Kuh-seng fine powder, with indigo naturalis ethanol extract, duckweed ethanol extract obtained in mixing supernatant obtained in S5 and S6 and
The mixing of fruit of summer cypress ethanol extract after concussion shakes up, is placed in the shady place that temperature is 0 ~ 28 DEG C and ferments 30 ~ 35 days, form tincture
For use.
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Citations (2)
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| CN106344697A (en) * | 2016-10-25 | 2017-01-25 | 马国坚 | Prescription for treating disease with traditional Chinese herbal medicine pseudolarix amabilis and making method |
| CN108478647A (en) * | 2018-07-06 | 2018-09-04 | 彭石浓 | One kind is for dermopathic Chinese medicine composition and its preparation, preparation method and purposes |
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|---|---|---|---|---|
| CN106344697A (en) * | 2016-10-25 | 2017-01-25 | 马国坚 | Prescription for treating disease with traditional Chinese herbal medicine pseudolarix amabilis and making method |
| CN108478647A (en) * | 2018-07-06 | 2018-09-04 | 彭石浓 | One kind is for dermopathic Chinese medicine composition and its preparation, preparation method and purposes |
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