CN109528607A - Skin barrier remediation composition and skin barrier repair product - Google Patents
Skin barrier remediation composition and skin barrier repair product Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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Abstract
A kind of skin barrier remediation composition and skin barrier repair product, are related to daily chemicals field.This skin barrier remediation composition includes: the first effective component of 1-30 parts by weight, second effective component of 0-20 parts by weight, the pseudo-ginseng flower extract of 0.5-3 parts by weight, the Herba Lysimachiae foenumgraeci extract of 0.1-3 parts by weight, the Rhizoma Paridis extract of 0.01-2 parts by weight, first effective component is selected from least one of oil and fat of sacha inchi and oil and fat of sacha inchi microcapsule powder, second effective component is selected from least one of phytosterol and phytosterol microcapsule powder, pass through reasonable component selection and reasonable component proportion, with safely and effectively skin barrier repairing performance, it can effectively solve the reparation problem after skin barrier is damaged, also skin resistance can be improved.Include the skin barrier reparation product of skin barrier remediation composition, achievees the purpose that skin barrier is safely and effectively repaired by being used for purported skin position outside.
Description
Technical field
The present invention relates to daily chemicals fields, and in particular to a kind of skin barrier remediation composition and skin barrier reparation produce
Product.
Background technique
The structure basis of skin barrier is mainly cuticula and epidermis lipid, natural moisturizing factor etc..The skin of health
Barrier can resist extraneous nuisance, stimulant and daylight infringement skin, while have moisturizing and adjustment effect.However, environment,
The reasons such as the skin nursing of diet and mistake, skin barrier is easy to be damaged, so that skin self-defense scarce capacity, leads to skin
Sensitivity, aging, drying, furfur, while a variety of anaphylactogens pass through skin defence line, and then lead to eczema, atopic dermatitis, skin scabies
The disease incidence of disease etc. of itching gradually increases.
It is safe how to find use, and can effectively restore the product of skin barrier, becomes asking for people's growing interest
Topic.
Summary of the invention
The embodiment of the present invention provides a kind of skin barrier remediation composition, passes through reasonable component selection and reasonable group
Distribution ratio has safely and effectively skin barrier repairing performance, can effectively solve the reparation problem after skin barrier is damaged, also can
Improve skin resistance.
The embodiment of the present invention provides a kind of skin barrier reparation product, due to including skin barrier remediation composition,
Therefore by being used for purported skin position outside, it can achieve the purpose that skin barrier is safely and effectively repaired.
The present invention solves its technical problem and adopts the following technical solutions to realize.
In a first aspect, the present invention proposes a kind of skin barrier remediation composition comprising:
The sanchi flower of first effective component of 1-30 parts by weight, the second effective component of 0-20 parts by weight, 0.5-3 parts by weight
The Herba Lysimachiae foenumgraeci extract of extract, 0.1-3 parts by weight, the Rhizoma Paridis extract of 0.01-2 parts by weight.
Optionally, above-mentioned skin barrier remediation composition includes: the first effective component of 1-30 parts by weight, 1-20 parts by weight
The second effective component, the pseudo-ginseng flower extracts of 0.5-3 parts by weight, 0.1-3 parts by weight Herba Lysimachiae foenumgraeci extract, 0.01-2 weight
The Rhizoma Paridis extract of part.
For example, the first effective component of 2-27 parts by weight, the second effective component of 2-17 parts by weight, 0.55-2.7 parts by weight
Pseudo-ginseng flower extract, 0.1-2.7 parts by weight Herba Lysimachiae foenumgraeci extract, the Rhizoma Paridis extract of 0.02-1.9 parts by weight.
Wherein, the first effective component is selected from least one of oil and fat of sacha inchi and oil and fat of sacha inchi microcapsule powder, and second effectively
Ingredient be selected from least one of phytosterol and phytosterol microcapsule powder, such as the first effective component be oil and fat of sacha inchi or
For oil and fat of sacha inchi microcapsule powder or be oil and fat of sacha inchi and oil and fat of sacha inchi microcapsules mixture.Second effective component is plant steroid
Alcohol or for phytosterol microcapsule powder or be phytosterol and phytosterol microcapsule powder mixture.
Wherein, oil and fat of sacha inchi is a kind of natural green novel edible vegetable oil rouge extracted from U.S. rattan fruit kernel, can be straight
Purchase is connect in market.Oil and fat of sacha inchi is rich in the minerals such as protein, unsaturated fatty acid, vitamin E and calcium, phosphorus, iron.While its
Character such as water is easy to flow on skin, and energy hasty breaching skin barrier penetrates into subcutaneous tissue, and dry, work is prevented in moist moisturizing
Change subcutaneous microcirculation, promotes the absorption of grease and nutriment, and layer protecting film can be formed on surface, prevent moisture
And the loss of nutriment, and since it is rich in vitamin E etc., there is moisturizing, delay skin aging, prevent from staying scar etc.
Effect, but since it is rich in unsaturated fatty acid, when use, is oxidized easily.
Phytosterol is a kind of steroid compound containing hydroxyl being present in plant, is extracted from vegetable fat
To sterol, have the characteristics that nutritive value is high, physiological activity is strong.Phytosterol has the thermostabilization of good antioxidant, Liang Hai
Property, promote wound healing, to skin have mild permeability, promote skin metabolism, on the one hand can be with U.S. rattan fruit
Oil cooperation, the common moisture for keeping skin surface, prevents skin aging, provides skin-nourishing, on the other hand, with oil and fat of sacha inchi
Cooperation, can prevent oil and fat of sacha inchi to be oxidized, and improve the stability of skin barrier remediation composition.
Herba Lysimachiae foenumgraeci extract can be clearing heat and detoxicating, cleaning skin, and anti-oxidant, control oil promotes regeneration of damaged tissue extensive
Equal skin-protecting functions again, pseudo-ginseng flower extract and Rhizoma Paridis extract, further increase it is clearing heat and detoxicating, it is swelling and pain relieving, anti-inflammatory anti-infective,
Regeneration of damaged tissue is promoted to restore.Herba Lysimachiae foenumgraeci extract, pseudo-ginseng flower extract, Rhizoma Paridis extract and oil and fat of sacha inchi and phytosterol
Mixing promotes the suction of skin Herba Lysimachiae foenumgraeci extract, pseudo-ginseng flower extract, Rhizoma Paridis extract by oil and fat of sacha inchi and phytosterol
It receives, while oil and fat of sacha inchi can prevent phytosterol, Herba Lysimachiae foenumgraeci extract, pseudo-ginseng flower extract, Rhizoma Paridis extract in skin table
The loss in face extends the time of contact of a component and target position, further increases the efficiency of absorption, finally effectively improve skin
The effect of barrier reparation.Simultaneously because oil and fat of sacha inchi, phytosterol in use in ingress of air, receive the process of illumination
In it is easy to oxidize, and the addition of Herba Lysimachiae foenumgraeci extract, pseudo-ginseng flower extract etc. can also improve the stability of oil and fat of sacha inchi, slow down
Oxidation.Above-mentioned each component extracts from natural plants simultaneously, has green and natural type, and use is safer.
To sum up, by the reasonable cooperation of each ingredient, from cleaning skin, moisturizing skin care, antibacterial anti-inflammatory analgesic, healing is promoted to repair
Again and prevent from staying scar etc. after repairing, it is complete to carry out skin barrier reparation, it is more green and healthy effective.
With reference to first aspect, according to some embodiments of the present invention, above-mentioned first effective component is oil and fat of sacha inchi microcapsules
Powder；By the design of micro powder capsules, prevent oil and fat of sacha inchi ingress of air, by illumination during aoxidize, meanwhile, prevent water
Oil layer can make the quality of skin barrier remediation composition more uniform, that is to say that the outer wall of micro powder capsules is hydrophily, and
And during using product, microcapsules are opened by external force, do not influence using effect.
Some specific embodiments according to the present invention, above-mentioned oil and fat of sacha inchi microcapsule powder include that mass ratio is (30-45):
The oil and fat of sacha inchi of (65-70) and the first wall material, the first wall material are wrapped in oil and fat of sacha inchi.Such as oil and fat of sacha inchi microcapsule powder includes matter
Amount is than the oil and fat of sacha inchi and the first wall material for 30:65,30:70,33:68,35:69,40:66,45:65 or 45:70 etc., the ratio
In range, the oil and fat of sacha inchi that oil and fat of sacha inchi microcapsule powder contains is more, while being convenient for being easy to microcapsules by external force when subsequent use
Effect is opened, while the comfort that the first wall material will not influence using effect and use, and guarantees oil and fat of sacha inchi performance.
Optionally, the first wall material is selected from soybean protein isolate, maltodextrin, cyclodextrin, gelatin, Arabic gum, casein
At least one of sour sodium and sodium alginate, such as the first wall material is maltodextrin and Arabic gum or the first wall material is soybean
Protein isolate and gelatin etc., those skilled in the art can select according to the actual situation.
According to some embodiments of the present invention, above-mentioned first wall material includes that weight ratio is followed successively by (45-55): (1-4): (5-
12) soybean protein isolate, maltodextrin and Arabic gum, such as above-mentioned first wall material include that weight ratio is followed successively by 45:1:
5, the soybean protein isolate of 45:3:10,47:2:7,50:1:8,52:4:11 or 55:4:12 etc., maltodextrin and Arab
Glue, by the restriction of soybean protein isolate, maltodextrin and Arabic gum so that the first wall material hydrophily is good, can sufficiently with
Water mixing, guarantees the homogeneity of skin barrier remediation composition.
Optionally, maltodextrin is the maltodextrin that percent hydrolysis value is 20, and the effect of solubility and holding moisture is preferable,
Improve the cementability and toughness between the first wall material.In order to keep original property of optimal oil and fat of sacha inchi, the first wall material
In without using any emulsifier, and select to use soybean protein isolate, maltodextrin and Arabic gum, soybean protein isolate has
Good emulsifiability, but water solubility is not that very well, very well, the solution viscosity of formation is small, still for the water solubility of maltodextrin
Emulsifiability is very poor, and Arabic gum viscosity is high, and lowers by some time viscosity, three's interworking, can be complementary, is formed steady
Fixed homogeneous phase preferably embeds oil and fat of sacha inchi, while subsequent will not generate the problems such as viscosity is big.
It should be noted that oil and fat of sacha inchi microcapsule powder can directly be bought in market, can also voluntarily prepare.
Optionally, the preparation method of some specific embodiments according to the present invention, above-mentioned oil and fat of sacha inchi microcapsule powder includes
Following steps:
Soybean protein isolate is mixed with first part's water according to mass ratio for 4.5-6:2-3.5, is added in 80-85 DEG C of water-bath
Hot 10-20min, be added maltodextrin, Arabic gum, oil and fat of sacha inchi and surplus water, obtain the first mixed liquor, wherein the
The quality of one mixed liquor is 9-11 times of the quality of soybean protein isolate.
By the first mixed liquor emulsifying homogeneous, spray drying.
Optionally, emulsifying homogeneous includes that the first mixed liquor is placed on oscillator to vibrate 10-15h, crosses colloid mill at least 1
It is secondary, homogeneous at least 1 time under 45-55 DEG C, the pressure of 18-23MPa, and then makes respectively to divide equally and adequately mix.
Optionally, spray drying includes: by the first mixed liquor after emulsifying homogeneous at 150-160 DEG C of inlet air temperature, into
60-70 DEG C of material temperature degree is spray-dried under conditions of 60-70 DEG C of leaving air temp.
Oil and fat of sacha inchi microcapsule powder is applied in skin care item in order to prevent, generates stability influence for skin care item, spraying
The product obtained after dry crosses 70-100 mesh, can obtain the powdery microcapsule product of white uniformity.
With reference to first aspect, according to some embodiments of the present invention, above-mentioned second effective component is phytosterol microcapsules
Powder, by the design of micro powder capsules, prevent phytosterol ingress of air, by illumination during aoxidize, meanwhile, prevent water
Oil layer can make the quality of skin barrier remediation composition more uniform, that is to say that the outer wall of micro powder capsules is hydrophily, and
And during using product, microcapsules are opened by external force, do not influence using effect.
Some specific embodiments according to the present invention, above-mentioned phytosterol microcapsule powder include that weight ratio is followed successively by (50-
60): (5-7): the phytosterol of (120-140), the first emulsifier and the second wall material, the second wall material are wrapped in phytosterol and
One emulsifier.Such as it is 50:7:120,53:5:125,55:6:129,56:5.5 that phytosterol microcapsule powder, which includes mass ratio:
130, phytosterol part of 57:6.5:133,58:7:135 or 60:7:140 etc., the first emulsifier and the second wall material, the ratio
In range, the phytosterol that phytosterol microcapsule powder contains is more, while being convenient for being easy to microcapsules by external force when subsequent use
Effect is opened, while the comfort that the second wall material will not influence using effect and use, and guarantees phytosterol performance.And
And since phytosterol is also insoluble in water, and there is no emulsifiability, therefore the addition of the first emulsifier can promote phytosterol
Preferably embedding, enhances the water solubility of phytosterol, convenient for the absorption of subsequent phytosterol.
Optionally, the second wall material is selected from soybean protein isolate, maltodextrin, cyclodextrin, gelatin, Arabic gum, casein
At least one of sour sodium and sodium alginate, such as the second wall material is maltodextrin and Arabic gum or the second wall material is soybean
Protein isolate and gelatin etc., those skilled in the art can select according to the actual situation.
With reference to first aspect, according to some embodiments of the present invention, it is (11-14) that above-mentioned second wall material, which includes weight ratio:
The cyclodextrine and Arabic gum of (0.5-2)；Such as above-mentioned second wall material includes that weight ratio is followed successively by 11:0.5,12:1,13:
1.5, the cyclodextrine and Arabic gum of 14:2 or 14:1 etc., by the restriction of cyclodextrine and Arabic gum, so that
Two wall material hydrophilies are good, can sufficiently mix with water, guarantee the homogeneity of skin barrier remediation composition.
Optionally, cyclodextrine (β-cyclodextrin abbreviation β-CD) is the product that starch is generated through acidolysis cyclisation,
It can be increased by inclusion complex with the various compound molecules of envelope to the stability of photo-thermal, oxygen, appearance has hydrophily, interior table tool
There is lipophilicity, effectively improve the hydrophily of phytosterol, Arabic gum viscosity is high, and lowers by some time viscosity, two
Person's interworking, can be complementary, forms stable homogeneous phase, phytosterol is preferably embedded, while subsequent will not to generate viscosity big
The problems such as.
Optionally, the first emulsifier is in sucrose fatty ester, lecithin, glycerin monostearate (alias monoglyceride)
At least one, such as the first emulsifier is compound first emulsifier etc. that sucrose fatty ester and lecithin are constituted.
Some specific embodiments according to the present invention, above-mentioned first emulsifier are monoglyceride, not soluble in water and glycerol, energy
It is stable in hot water, there is lipophilicity, simultaneously because Arabic gum generally dissolves in hot water, therefore the selection of monoglyceride, make
Obtain the stability of phytosterol microcapsule powder more preferably.The water that hot water is 65-80 DEG C herein.
It should be noted that phytosterol microcapsule powder can directly be bought in market, can also voluntarily prepare.
Optionally, the preparation method of some specific embodiments according to the present invention, above-mentioned phytosterol microcapsule powder includes
Following steps:
Arabic gum is dissolved in 65-70 DEG C of water, is then added to by the lysate of cyclodextrine, phytosterol is added
With the first emulsifier, the second mixed liquor is obtained, wherein the quality of the second mixed liquor is 48-52 times of the quality of Arabic gum.
Mixed liquor emulsifying homogeneous, spray drying by the.
Optionally, emulsifying homogeneous include by the second mixed liquor under 45-55 DEG C, the pressure of 18-23MPa homogeneous at least 1
It is secondary, and then make respectively to divide equally and adequately mix.
Optionally, spray drying includes: by the second mixed liquor after emulsifying homogeneous at 150-160 DEG C of inlet air temperature, into
60-70 DEG C of material temperature degree is spray-dried under conditions of 60-70 DEG C of leaving air temp.
Phytosterol microcapsule powder is applied in skin care item in order to prevent, generates stability influence for skin care item, spraying
The product obtained after dry crosses 70-100 mesh, can obtain the powdered plant sterol microcapsule product of white uniformity.
With reference to first aspect, according to some embodiments of the present invention, above-mentioned pseudo-ginseng flower extract is selected from sanchi flower water and mentions
At least one of object, sanchi flower ultrasonic wave extraction object, sanchi flower supercritical extract are taken, can directly be bought in market,
Can also voluntarily prepare, but it is noted that pseudo-ginseng flower extract provided in an embodiment of the present invention be water base extract, be convenient for
Subsequent skin absorbs, and water base extract herein refers to using water as Extraction medium, extracts in conjunction with modes such as other ultrasonic waves
Extract, avoid the organic reagents such as ethyl alcohol as extract reagent when, be easy residual solvent, cause influence skin barrier reparation
The performance of composition.
Hold it is above-mentioned, optionally, preferably pseudo-ginseng flower extract be sanchi flower water mention extract.
With reference to first aspect, some specific embodiments according to the present invention, sanchi flower water mentions extract can be by following system
Preparation Method is made: being that sanchi flower is crushed powdering, the water measured with 8-12 times flows back in 85 DEG C of -90 DEG C of boilings, continuously extracts three
Secondary, each extraction time is followed successively by 1.3-2h, 0.8-1.2h, 0.3-0.7h, then filters extracting solution and merges, be concentrated under reduced pressure at
Medicinal extract or dry powdering.
According to some embodiments of the present invention, above-mentioned Herba Lysimachiae foenumgraeci extract is selected from lavender liquid to mention extract, lavender super
At least one of sound wave extract, lavender supercritical extract can directly be bought in market, can also voluntarily make
It is standby, but it is noted that Herba Lysimachiae foenumgraeci extract provided in an embodiment of the present invention is only water base extract, convenient for subsequent skin
When absorbing, while avoiding the organic reagents such as ethyl alcohol as reagent is extracted, it is easy residual solvent, causes to influence skin barrier reparation
The performance of composition.
Hold it is above-mentioned, optionally, preferably Herba Lysimachiae foenumgraeci extract be lavender liquid mention extract.Lavender liquid proposes the system of extract
Preparation Method proposes the preparation method of extract with sanchi flower water, does not illustrate herein.
With reference to first aspect, according to some embodiments of the present invention, above-mentioned Rhizoma Paridis extract be selected from Paris polyphylla water mention extract,
At least one of Paris polyphylla ultrasonic wave extraction object, Paris polyphylla supercritical extract can directly be bought in market, can also be voluntarily
Preparation, but it is noted that Rhizoma Paridis extract provided in an embodiment of the present invention is only water base extract, convenient for subsequent skin
When absorbing, while avoiding the organic reagents such as ethyl alcohol as reagent is extracted, it is easy residual solvent, causes to influence skin barrier reparation
The performance of composition.
Hold it is above-mentioned, optionally, preferably Rhizoma Paridis extract be Paris polyphylla water mention extract.Paris polyphylla water proposes the preparation method of extract
The preparation method that extract is mentioned with sanchi flower water, does not illustrate herein.
To sum up, skin barrier remediation composition directly mixes, and matches in use, can according to need with auxiliary material appropriate
Close, suitable for make an addition to skin care item, repair product it is medium use as skin barrier repair additive.
Second aspect, the embodiment of the present invention provide a kind of skin barrier reparation product, and it includes above-mentioned skin barrier reparations
Composition, while the content of skin barrier remediation composition is the 2.61wt%-58wt% that skin barrier repairs product quality, skin
The dosage form that skin barrier repairs product is exterior-applied formulation.
Wherein, optionally, the content of skin barrier remediation composition be skin barrier repair product quality 2.61wt%,
5wt%, 10wt%, 15wt%, 20wt%, 30wt%, 35wt%, 40wt%, 45wt% or 58wt% etc., within the scope of this, skin
Skin barrier repair is good, and external application repairing effect is good.
In conjunction with second aspect, according to some embodiments of the present invention, skin barrier reparation product is reparation water, reparation is newborn,
Repair cream, repair facial mask, repairing paste or repair gel, in addition to this, can be also used for facial cleanser etc. repair face cleaning product, with
And repair mouthwash, the toothpaste etc. of class.It is noted that facial mask herein includes the white shape or gel for being directly coated on face
Facial mask, or immersed with non-woven fabrics, silk of skin barrier remediation composition etc. have true form facial mask.
Optionally, in some specific embodiments according to the present invention, by mass percentage, skin barrier repairs product packet
Include the auxiliary material of 6%-40% and the deionized water of surplus.Wherein, auxiliary material is the acceptable customary adjuvant of cosmetic field or medicine
Acceptable customary adjuvant on, while the addition of deionized water further enhance the stability that skin barrier repairs product.
Optionally, auxiliary material includes at least one of the second emulsifier, moisturizer, preservative and surfactant, is needed
Illustrate, auxiliary material is not limited only to above-mentioned, can also add other customary adjuvants.Such as dispersing agent, thickener etc., this field skill
Art personnel can select according to practical situation.
Optionally, moisturizer is selected from lactic acid, glycerol, allantoin, Sodium Hyaluronate, trehalose and 1, in 3 butanediols extremely
Few one kind；Preferably, the second emulsifier is selected from stearine, cetostearyl alcohol, dimethyl silicone polymer, polyethylene glycol-
At least one of 14M, docosyl alcohol polyethers -25 and stereth -21；Preferably, preservative is selected from Phenoxyethanol, DMDM
At least one of hydantoins, methyl hydroxybenzoate, Nipasol, methylisothiazolinone and parahydroxyacet-ophenone.Above-mentioned moisturizing
Using safely and effectively, those skilled in the art can voluntarily be selected for agent, the second emulsifier and preservative.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Feature and performance of the invention are described in further detail with reference to embodiments.
It should be noted that embodiment 1-15 provided by the invention, pseudo-ginseng flower extract, Herba Lysimachiae foenumgraeci extract, Yi Jichong
Building extract is that water mentions extract.
The oil and fat of sacha inchi microcapsules that embodiment 1-15 provided by the invention is used are made with the following method:
The soybean protein isolate of 500 parts by weight is added in the water of 300 parts by weight and be uniformly mixed, in 80-85 DEG C of water-bath
The maltodextrin (DE value is 20) of 220 parts by weight, the Arabic gum of 80 parts by weight, the beauty of 500 parts by weight are added after holding 15min
Rattan fruit oil, adds water to the mixing of 5000 parts by weight, obtains the first mixed liquor.
First mixed liquor is placed on oscillator and vibrates 12h, is crossed colloid mill 2 times, under 50 DEG C, the pressure of 20MPa
It is spray-dried under conditions of 150-160 DEG C of inlet air temperature, 60-70 DEG C of feeding temperature, 60-70 DEG C of leaving air temp after matter 2 times, mistake
80 meshes obtain the powdery microcapsule product of white uniformity.
The pico- capsule of phytosterol that embodiment 1-15 provided by the invention is used is made with the following method:
The cyclodextrine of 1200 parts by weight is dissolved in the water of 1200 parts by weight and obtains cyclodextrine lysate, by 100 weights
Amount part Arabic gum dissolve in 65-70 DEG C of water and plus people into cyclodextrine lysate, be then added containing 1% list it is sweet
600 parts by weight of phytosterol of rouge add water to the mixing of 5000 parts by weight, obtain the second mixed liquor.
By the second mixed liquor homogeneous 2 times under 50 DEG C, the pressure of 20MPa, then at 150-155 DEG C of inlet air temperature, into
60-70 DEG C of material temperature degree is spray-dried under conditions of 45-50 DEG C of leaving air temp, is crossed 80 meshes, is obtained the powdered plant steroid of white uniformity
Alcohol microcapsule product.
Embodiment 1-5
Embodiment 1-5 provides a kind of reparation facial mask, the composition of raw materials and weight percent of the corresponding facial mask liquid of each embodiment
It is more as shown in table 1 than content.
The reparation facial mask liquid raw material of 1 embodiment 1-5 of table forms
Wherein, the manufacture craft of the reparation facial mask of embodiment 1-5 carries out in accordance with the following steps:
1) by load weighted oil and fat of sacha inchi microcapsules, phytosterol microcapsules, pseudo-ginseng flower extract, Herba Lysimachiae foenumgraeci extract,
The solids small powder such as Rhizoma Paridis extract is put into premixing tank, and stirring in load weighted water, which is added, makes material suck stirring after completely dissolution
In pot, starting blender is stirred 2-3 minutes.
2) load weighted hydroxyethyl cellulose is added in load weighted water to stir 5-10 minutes and makes material after completely dissolution,
It sucks in agitated kettle, starting blender stirs 2-3 minutes.
3) by load weighted hyaluronic acid, trehalose, propylene glycol sucking agitated kettle, starting blender is stirred evenly.
4) methylisothiazolinone, essence are put into agitated kettle together, and stirred 5-10 minutes, is allowed to mix completely,
It opens and is stirred under vacuum 10-15 minutes；Obtain repair surface film liquid.
5) facial mask liquid will be repaired to pour into the facial mask bag for having folded face paper.
Embodiment 6-10
Embodiment 6-10 provides a kind of reparation gel, the corresponding composition of raw materials and weight hundred for repairing gel of each embodiment
Divide more as shown in table 2 than content.
The raw material composition of the reparation gel of 2 embodiment 6-10 of table
Wherein, the manufacture craft of the reparation gel of embodiment 6-10 carries out in accordance with the following steps:
1) by load weighted oil and fat of sacha inchi microcapsules, phytosterol microcapsules, pseudo-ginseng flower extract, Herba Lysimachiae foenumgraeci extract,
The solids small powder such as Rhizoma Paridis extract is put into premixing tank, and stirring in load weighted water, which is added, makes material suck stirring after completely dissolution
In pot, starting blender is stirred 2-3 minutes；
2) load weighted hyaluronic acid, glycerine polyacrylate, 1,3 butanediols, the sucking of galactolipin araban are stirred
It mixes in pot, starting blender stirs evenly；
3) methylisothiazolinone, essence are put into agitated kettle together, and stirred 5-10 minutes, is allowed to mix completely,
It opens and is stirred under vacuum 10-15 minutes；It obtains repairing gel.
Embodiment 11-15
Embodiment 11-15 provides a kind of reparation cream, the corresponding composition of raw materials for repairing cream of each embodiment and weight percent
It is more as shown in table 3 than content.
The raw material composition of the reparation cream of 3 embodiment 11-15 of table
Wherein, the manufacture craft of the reparation cream of embodiment 11-15 carries out in accordance with the following steps:
1) by load weighted oil and fat of sacha inchi microcapsules, phytosterol microcapsules, pseudo-ginseng flower extract, Herba Lysimachiae foenumgraeci extract,
The solids small powder such as Rhizoma Paridis extract is put into premixing tank, is heated in 80 DEG C -85 DEG C, and stirring in load weighted water, which is added, makes material
After completely dissolution, the stirring of starting blender 2-3 minutes are A phase, spare；
2) load weighted Sodium Polyacrylate, PPG-5- laureth -5, dormant oil, jojoba seed oil are put into premixing tank
In, it is heated in 80 DEG C -85 DEG C, starting blender stirring 2-3 minutes are B phase, spare；
3) A phase is poured into emulsifying in B phase to stir, starts magnetic heating stirrer, control stirring rate is 3000r/
Min is slowly added to, and reacts 15min, is stopped heating, is kept stirring, and is C phase when slow cooling is to 50 DEG C.
3) Phenoxyethanol, essence are put into C phase to stir evenly together, homogeneous 2 minutes, continues to be cooled to 45 DEG C of dischargings, i.e.,
It obtains repairing essence cream.
Embodiment 16
The present embodiment provides a kind of reparation cream, the difference with embodiment 11 is only that:
Each ingredient in oil and fat of sacha inchi microscapsule powder are as follows: purification oil and fat of sacha inchi 80g, wall material (in its mass ratio, gelatin: Ah
Draw primary glue=2:1) 9.5g, stabilizer (sodium carboxymethylcellulose: xanthan gum=1:1) 0.13g, filler (maltodextrin) 23g,
Emulsifier (monoglyceride: sucrose ester=1:1) 2.5g.
Embodiment 17
The present embodiment provides a kind of reparation cream, the difference with embodiment 11 is only that:
In formula, directly adding is oil and fat of sacha inchi and phytosterol.
Comparative example 11 and embodiment 17, directly addition oil and fat of sacha inchi and phytosterol, obtained reparation cream is easily
It generates and is layered, and the shelf-life does not have embodiment 11 long, is easy failure, still, the reparation cream now provided with use, embodiment 17
Have effects that preferably to repair.
Test example
Transepidermal water loss rate (TEWL) is a kind of important indicator for reflecting skin barrier function, the increasing of transepidermal water loss rate (TEWL)
Add it is considered that related to skin barrier function decline.
Take non-invasive skin test method to tested area's transepidermal water loss rate (transdermallossofwater, TEWL) into
Row detection.Use UVB irradiation to establish rat light Ageing Model, the results show that the tested rat skin TEWL value of UVB irradiation group is bright
It is aobvious to be higher than blank control group.The case where product of the present invention is applied to the raised rat back of TEWL value, detects TEWL value, TEWL
It is effective to rat skin barrier function reparation that value, which reduces prompt product of the present invention,.
The product of embodiment 1, embodiment 3, embodiment 6, embodiment 9, embodiment 11, embodiment 15 is selected to be tested.
Select SPF grades of rats (Kunming animal institute) of 210 Healthy females, weight 180-200g.
210 healthy adult female rats are divided into blank control group and experimental group by table of random numbers method, every group 30.Rat
After carrying out adaptive feeding 1 week, started to receive UVB irradiation at the 2nd week, establish model.Each group SD rat back hair is wiped out
2cm × 2cm takes shaving to handle before rear irradiation every time.Modeling Success Flag is that rat skin light aging variation occurs (i.e.
There is situations such as furfur, erythema, wrinkle).
It is grouped respectively after modeling success in the rat back of experimental group and smears embodiment 1, embodiment 3, embodiment 6, implements
The product of example 9, embodiment 11, embodiment 15, blank group smear glycerol, smear 1h, 2h, 3h after to the tested area's skin of each group rat
TEWL value is measured using Tewameter instrument.Every rat carries out 3 repetitions and detects, and is then averaged.Test result such as table 4
It is shown:
4 experimental result of table
Difference is statistically significant (P < 0.05).
It can be obtained according to experimental result shown in table 4, external application product of the present invention can reduce rat skin light Ageing Model
TEWL value can generate repairing effect to skin barrier function.
Test example 2
The selection age 25 years old to 60 years old, there is the symptom of drying, skin aging, furfur in skin of face, while skin is without bright
Subject 60 of aobvious wound, are randomly divided into 3 groups, every group of 20 people, and the 1st group is repaired facial mask using embodiment 3, and 2-3 times weekly, the
After 2 groups wash one's face sooner or later daily, gel is repaired using embodiment 8, after the 3rd group washes one's face sooner or later daily, the reparation used is newborn.Use 1
The test of end in a month.
After the test, the 1st group, the 2nd group and the 3rd group of subject do not occur erythema and itch, nonirritant symptom
Occur, shows that skin barrier provided in an embodiment of the present invention repairs product and do not have the safety issues such as skin irritatin.
Simultaneously through the 1st group, the 2nd group and the 3rd group subject feedback, skin barrier reparation provided in an embodiment of the present invention is produced
Product have good moisturizing effect, and it is full to will increase skin water profit, keeps the smooth water of skin tender, and dry phenomenon of peeling is obviously improved,
Part has the subject of acne or small pox simultaneously, and inflammation is obviously improved, and has certain desalination wrinkle, makes skin smooth
Flexible effect.
To sum up, the skin barrier remediation composition of the embodiment of the present invention passes through reasonable component selection and reasonable group
Distribution ratio has safely and effectively skin barrier repairing performance, can effectively solve the reparation problem after skin barrier is damaged, also can
Improve skin resistance.Skin barrier comprising skin barrier remediation composition repairs product, by being used for purported skin position outside
It sets, achievees the purpose that skin barrier is safely and effectively repaired.
Embodiments described above is a part of the embodiment of the present invention, instead of all the embodiments.Reality of the invention
The detailed description for applying example is not intended to limit the range of claimed invention, but is merely representative of selected implementation of the invention
Example.Based on the embodiments of the present invention, obtained by those of ordinary skill in the art without making creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
Claims (10)
1. a kind of skin barrier remediation composition, characterized in that it comprises:
The sanchi flower extraction of the first effective component, the second effective component of 0-20 parts by weight, 0.5-3 parts by weight of 1-30 parts by weight
The Herba Lysimachiae foenumgraeci extract of object, 0.1-3 parts by weight, the Rhizoma Paridis extract of 0.01-2 parts by weight；
Wherein, first effective component be selected from least one of oil and fat of sacha inchi and oil and fat of sacha inchi microcapsule powder, described second
Effective component is selected from least one of phytosterol and phytosterol microcapsule powder.
2. skin barrier remediation composition according to claim 1, which is characterized in that first effective component is U.S. rattan
Fruit oil microcapsule powder；
Preferably, it is (30-45): the oil and fat of sacha inchi of (65-70) and the first wall that the oil and fat of sacha inchi microcapsule powder, which includes mass ratio,
Material, first wall material are wrapped in the oil and fat of sacha inchi.
3. skin barrier remediation composition according to claim 2, which is characterized in that first wall material includes weight ratio
It is followed successively by (45-55): (1-4): soybean protein isolate, maltodextrin and the Arabic gum of (5-12).
4. skin barrier remediation composition according to claim 1, which is characterized in that second effective component is plant
Sterol microcapsule powder；
Preferably, the phytosterol microcapsule powder includes that weight ratio is followed successively by (50-60): (5-7): the plant of (120-140)
Sterol, the first emulsifier and the second wall material, second wall material are wrapped in the phytosterol and first emulsifier.
5. skin barrier remediation composition according to claim 4, which is characterized in that second wall material includes weight ratio
For (11-14): the cyclodextrine and Arabic gum of (0.5-2)；
Preferably, first emulsifier is monoglyceride.
6. skin barrier remediation composition according to claim 1, which is characterized in that the pseudo-ginseng flower extract is selected from three
At least one of seven Hua Shuiti extracts, sanchi flower ultrasonic wave extraction object, sanchi flower supercritical extract, preferably sanchi flower
Water mentions extract；
Preferably, the Herba Lysimachiae foenumgraeci extract is selected from Herba Lysimachiae foenumgraeci extract water and mentions extract, Herba Lysimachiae foenumgraeci extract ultrasonic wave extraction
At least one of object, Herba Lysimachiae foenumgraeci extract supercritical extract, preferably lavender liquid mentions extract；
Preferably, Rhizoma Paridis extract is selected from Rhizoma Paridis extract water and proposes extract, Rhizoma Paridis extract ultrasonic wave extraction object, Paris polyphylla extraction
At least one of object supercritical extract, preferably Paris polyphylla water mention extract.
7. a kind of skin barrier repairs product, which is characterized in that it includes skin barriers as claimed in any one of claims 1 to 6
Remediation composition, the content of the skin barrier remediation composition are the 2.61wt%- that the skin barrier repairs product quality
58wt%, the dosage form that the skin barrier repairs product is exterior-applied formulation.
8. skin barrier according to claim 7 repairs product, which is characterized in that it is to repair that the skin barrier, which repairs product,
Rehydration repairs cream, repair cream, repairs facial mask, repairing paste or repairs gel.
9. skin barrier according to claim 7 or 8 repairs product, which is characterized in that by mass percentage, the skin
It includes the auxiliary material of 6%-40% and the deionized water of surplus that skin barrier, which repairs product,.
10. skin barrier according to claim 9 repairs product, which is characterized in that the auxiliary material include the second emulsifier,
At least one of moisturizer, preservative and surfactant；
Preferably, the moisturizer is selected from lactic acid, glycerol, allantoin, Sodium Hyaluronate, trehalose and 1, in 3 butanediols extremely
Few one kind；Preferably, second emulsifier is selected from stearine, cetostearyl alcohol, dimethyl silicone polymer, poly- second two
At least one of alcohol -14M, docosyl alcohol polyethers -25 and stereth -21；Preferably, the preservative is selected from benzene oxygen second
At least one of alcohol, DMDM hydantoin, methyl hydroxybenzoate, Nipasol, methylisothiazolinone and parahydroxyacet-ophenone.
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Application publication date: 20190329 |