CN109528587A - One kind is based on private gene customization cleawhite over-night essences and preparation method thereof - Google Patents

One kind is based on private gene customization cleawhite over-night essences and preparation method thereof Download PDF

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Publication number
CN109528587A
CN109528587A CN201811574913.9A CN201811574913A CN109528587A CN 109528587 A CN109528587 A CN 109528587A CN 201811574913 A CN201811574913 A CN 201811574913A CN 109528587 A CN109528587 A CN 109528587A
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Prior art keywords
acid
parts
glycerol
sodium
private
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CN201811574913.9A
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Inventor
黄惠先
卢健伟
林学智
易丹华
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Guangzhou Cohen Biotechnology Co Ltd
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Guangzhou Cohen Biotechnology Co Ltd
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Priority to CN201811574913.9A priority Critical patent/CN109528587A/en
Publication of CN109528587A publication Critical patent/CN109528587A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses one kind based on private gene customization cleawhite over-night essences and preparation method thereof, it is related to technical field of skin care, the technical issues of solution is how to improve skin-protection product melanin reduced rate, enhance white-skinned face function, raw material proportioning is carried out according to private genetic test, include following raw material: deionized water, two glycerol, acrylic acid (ester) class/C10~30 alkylol acrylamide acid esters cross-linked polymer, glycerol, Sodium Polyacrylate, butanediol, Sodium Hyaluronate, disodium ethylene diamine tetraacetate, parahydroxyacet-ophenone, decoyl hydroximic acid, niacinamide, Tujue's rose water, Gotu Kola P.E, succinic acid diethoxy ethyl ester, tranexamic acid, dried tremella extract, tremella polysaccharides, trehalose, turn round thorn Cactus Pedicel extract, tapioca, sodium hydroxide and fibronectin.Product of the present invention can be improved melanin reduced rate, and whitening effect is good.

Description

One kind is based on private gene customization cleawhite over-night essences and preparation method thereof
Technical field
The present invention relates to skin-protection product technical field, more particularly to it is a kind of based on private gene customization cleawhite over-night essences and its Preparation method.
Background technique
Whitening is always two big major function demands of the consumer to skin-protection product, especially domestic market, a white screening hundred Ugly traditional concept is even more that demand of the consumer to whitening product is allowed to reach ultimate attainment.With living standards of the people and aesthetical standard Raising, the pale skin with clean profit increasingly praised highly by most of women.By the use of Skin whitening care cosmetics, Asians can To obtain pale, bright and clean skin.Therefore, pouplarity is higher and higher in the market for whitening product.
It is influenced since modern people's life stress is larger, and by various living environments, causes the skin of people frequent Dry, intensely dark pool, the colour of skin are poor.With this condition, more beautiful jade sieve of whitening product in the market is met the eye on every side, but its is generally existing Melanin reduced rate is low, and whitening effect is unobvious, irritation is strong, unsafe feature.
Whitening and skin-protecting product category is various on the market, and feature is different, many consumers can not clearly according to itself Skin conditions choose the product for being suitble to oneself.Because the skin of people is had nothing in common with each other, there are Oily, dry skin, neutral skin Point of skin, combination and allergic skin, the whitening and skin-protecting product used according to the property of different skin are also just different Sample.In addition to this, the property feature of everyone skin depends on pathology, the skin of gene, the physiology of skin and skin Instantly the regulation of this seven big dimension of situation, territorial environment, age differences, seasonal variations, some high-end consumer groups are even each People is intended to obtain a cutaneous gene for oneself and the skin-protection product that developed, customizes skin care according to private gene and produces Product concept is gradually risen, and accurate skin care also becomes the preferred object of people's skin care.
Summary of the invention
In view of the deficiencies of the prior art, technical problem solved by the invention is how to improve the reduction of skin-protection product melanin Rate enhances white-skinned face function.
In order to solve the above technical problems, the technical solution adopted by the present invention is that a kind of customize whitening essence based on private gene Liquid carries out raw material proportioning according to private genetic test, is made of following material quality component:
60~100 parts of deionized water, 1~5 part of two glycerol, the crosslinking of acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 are poly- Close 0.1~1 part of object, 0~5 part of glycerol, 0.01~1 part of Sodium Polyacrylate, 0~10 part of butanediol, Sodium Hyaluronate 0.01~1 Part, 0.01~1 part of disodium ethylene diamine tetraacetate, 0.1~1 part of parahydroxyacet-ophenone, 0.1~1 part of decoyl hydroximic acid, niacinamide 0.1~5 part, 0.1~10 part of Tujue's rose water, 0.1~1 part of Gotu Kola P.E, succinic acid diethoxy ethyl ester 0.1~5 Part, 0.1~3 part of tranexamic acid, 0.1~3 part of dried tremella extract, 0.1~3 part of tremella polysaccharides, 0.1~2 part of trehalose turn round thorn celestial being People slaps 0.1~2 part of stem extraction, 0.1~1 part of tapioca, 0.01~0.5 part of sodium hydroxide, 0.01~5 part of fibronectin.
Another technical problem that the present invention solves, which is to provide one kind, can be improved melanin reduced rate, enhance white-skinned face function Skin care item preparation method.
In order to solve the above technical problems, the technical solution adopted by the present invention is that a kind of customize whitening essence based on private gene Liquid and preparation method thereof carries out raw material proportioning according to private genetic test, raw material components is made by formula, including following step It is rapid:
(1) by deionized water, two glycerol, acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 cross-linked polymer, sweet Oil, Sodium Polyacrylate, butanediol, Sodium Hyaluronate, disodium ethylene diamine tetraacetate, parahydroxyacet-ophenone, decoyl hydroximic acid, nicotinoyl Amine, Tujue's rose water, Gotu Kola P.E, succinic acid diethoxy ethyl ester, tranexamic acid, dried tremella extract, tremella polysaccharides, Trehalose, torsion thorn Cactus Pedicel extract, tapioca, sodium hydroxide, fibronectin have been weighed spare by formulation weight part;
(2) by acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 cross-linked polymer, Sodium Polyacrylate, hyaluronic acid Sodium, two glycerol, glycerol, butanediol, disodium ethylene diamine tetraacetate, parahydroxyacet-ophenone, 50~80 parts of deionized waters are heated to 80 ~85 DEG C, homogeneous uniform, dissolution obtain mixed solution completely, and mixed solution is kept the temperature 3 minutes;Preferably, the deionized water Number is 55 parts;
(3) when mixed solution is cooled to 60 DEG C, addition succinic acid diethoxy ethyl ester is divided in advance with remaining deionized water The niacinamide and tranexamic acid dissipated, is uniformly mixing to obtain new mixed solution;
(4) when new mixed solution is cooled to 45 DEG C, addition Tujue rose water, Gotu Kola P.E, tremella are extracted Object, tremella polysaccharides, trehalose, torsion thorn Cactus Pedicel extract, tapioca, sodium hydroxide, fibronectin stir evenly Obtain finished product.
Compared with prior art products, the invention has the benefit that
(1) niacinamide and tranexamic acid are added, the formation of melanin can be inhibited, while celestial using tremella, centella, torsion thorn People slaps the calm reparation skin of stem, fibronectin, and safety does not stimulate, and eliminates the trouble and worry of user;It is added to succinic acid diethyl Oxygroup ethyl ester can assign skin lubrication sense, moisturize the skin simultaneously;Tranexamic acid has the factor group for inhibiting melanin enhancing, from And thoroughly block and form the approach of melanin because of ultraviolet light irradiation, it allows blackspot no longer to thicken expansion, effectively prevent skin pigment Deposition;Niacinamide can inhibit to be transferred to horn cell from black cell to black corpusculum, and tremella, centella, turn round thorn celestial being The calm reparation skin of stem, fibronectin is slapped, keeps skin exquisiteness smooth, it is smooth penetrating.
(2) it can be improved melanin reduced rate, whitening effect is good;Preparation method simple process, production efficiency is higher, safety Effectively, nontoxic non-stimulated, it is suitble to the obscure person of all colours of skin to use.
Specific embodiment
A specific embodiment of the invention is further described below with reference to embodiment, but is not to limit of the invention It is fixed.
Embodiment:
One kind customizing cleawhite over-night essences based on private gene, raw material proportioning is carried out according to private genetic test, by following original Material quality component is made: 65 parts of deionized water, 2 parts of two glycerol, the crosslinking of acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 are poly- Close 0.5 part of object, 1 part of glycerol, 0.2 part of Sodium Polyacrylate, 5 parts of butanediol, 0.2 part of Sodium Hyaluronate, disodium ethylene diamine tetraacetate 0.1 part, 0.5 part of parahydroxyacet-ophenone, 0.4 part of decoyl hydroximic acid, 3 parts of niacinamide, 5 parts of Tujue's rose water, centella extraction 0.5 part of object, 2 parts of succinic acid diethoxy ethyl ester, 2 parts of tranexamic acid, 3 parts of dried tremella extract, 2 parts of tremella polysaccharides, trehalose 1 Part turns round thorn 1 part of Cactus Pedicel extract, 0.5 part of tapioca, 0.1 part of sodium hydroxide, 5 parts of fibronectin.
One kind customizing cleawhite over-night essences preparation method based on private gene, carries out raw material proportioning according to private genetic test, Raw material components are made by formula, comprising the following steps:
(1) by deionized water, two glycerol, acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 cross-linked polymer, sweet Oil, Sodium Polyacrylate, butanediol, Sodium Hyaluronate, disodium ethylene diamine tetraacetate, parahydroxyacet-ophenone, decoyl hydroximic acid, nicotinoyl Amine, Tujue's rose water, Gotu Kola P.E, succinic acid diethoxy ethyl ester, tranexamic acid, dried tremella extract, tremella polysaccharides, Trehalose, torsion thorn Cactus Pedicel extract, tapioca, sodium hydroxide, fibronectin have been weighed spare by formulation weight part;
(2) by acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 cross-linked polymer, Sodium Polyacrylate, hyaluronic acid Sodium, two glycerol, glycerol, butanediol, disodium ethylene diamine tetraacetate, parahydroxyacet-ophenone, 55 parts of deionized waters are heated to 80~85 DEG C, homogeneous uniform, dissolution obtain mixed solution completely, and mixed solution is kept the temperature 3 minutes;
(3) when mixed solution is cooled to 60 DEG C, addition succinic acid diethoxy ethyl ester is divided in advance with remaining deionized water The niacinamide and tranexamic acid dissipated, is uniformly mixing to obtain new mixed solution;
(4) when new mixed solution is cooled to 45 DEG C, addition Tujue rose water, Gotu Kola P.E, tremella are extracted Object, tremella polysaccharides, trehalose, torsion thorn Cactus Pedicel extract, tapioca, sodium hydroxide, fibronectin stir evenly Obtain finished product.
To embody the product of the present invention after-sun recovery impact of performance, it is provided with control experiment, selects 20 25~40 years old strong Health female volunteers, 10 one group of people are divided into two groups, and the 1st group uses product of the present invention, and the 2nd group uses commercial product, and subject is equal Without skin medical history, recipient site is normal, and tries out first 10 days and tested period does not smear any whitening and skin-protecting unrelated with experiment Product measure the content of melanin in human skin, evaluate the white-skinned face function of cleawhite over-night essences.
1 week, 2 weeks, 4 are tried out on the day before using Skin whitening care cosmetics and continuously using MEXAMETER MX18 skin pigment instrument The melanin content that its skin of face is measured after week takes its average value.It is higher to measure numerical value, illustrates that melanin content is got in skin It is high.
Melanin reduced rate=(use content-continuous use Skin whitening care cosmetics N weeks of melanin on the day before Skin whitening care cosmetics Melanin content afterwards) ÷ uses melanin content × 100% on the day before Skin whitening care cosmetics.
Melanin reduced rate is higher, illustrates that whitening effect is better.The whitening performance test data measured is as shown in the table:
The average value of the melanin reduced rate of the 1st group of volunteer using product of the present invention is high as can be seen from the above table Commercial product volunteer is used in the 2nd group, illustrates whitening effect of the invention better than commercial product.
Detailed description is made that embodiments of the present invention in conjunction with the embodiments above, but the present invention be not limited to it is described Embodiment.To those skilled in the art, without departing from the principles and spirit of the present invention, to these realities The mode of applying carries out various change, modification, replacement and variant are still fallen in protection scope of the present invention.

Claims (4)

1. one kind customizes cleawhite over-night essences based on private gene, which is characterized in that raw material proportioning is carried out according to private genetic test, It is made of following material quality component: 60~100 parts of deionized water, 1~5 part of two glycerol, acrylic acid (ester) alkane of class/C10~30 0.1~1 part of alcohol acrylate crosspolymers, 0~5 part of glycerol, 0.01~1 part of Sodium Polyacrylate, 0~10 part of butanediol, thoroughly Bright 0.01~1 part of matter acid sodium, 0.01~1 part of disodium ethylene diamine tetraacetate, 0.1~1 part of parahydroxyacet-ophenone, decoyl hydroximic acid 0.1~1 part, 0.1~5 part of niacinamide, 0.1~10 part of Tujue's rose water, 0.1~1 part of Gotu Kola P.E, succinic acid diethyl 0.1~5 part of oxygroup ethyl ester, 0.1~3 part of tranexamic acid, 0.1~3 part of dried tremella extract, 0.1~3 part of tremella polysaccharides, trehalose 0.1~2 part, 0.1~2 part of Cactus Pedicel extract of torsion thorn, 0.1~1 part of tapioca, 0.01~0.5 part of sodium hydroxide, fine company 0.01~5 part of albumen.
2. as described in claim 1 customize cleawhite over-night essences based on private gene, which is characterized in that by following material quality group Part is made: 65 parts of deionized water, 2 parts of two glycerol, acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 cross-linked polymer 0.5 It is part, 1 part of glycerol, 0.2 part of Sodium Polyacrylate, 5 parts of butanediol, 0.2 part of Sodium Hyaluronate, 0.1 part of disodium ethylene diamine tetraacetate, right 0.5 part of hydroxy acetophenone, 0.4 part of decoyl hydroximic acid, 3 parts of niacinamide, 5 parts of Tujue's rose water, 0.5 part of Gotu Kola P.E, 2 parts of succinic acid diethoxy ethyl ester, 3 parts of dried tremella extract, 2 parts of tremella polysaccharides, 1 part of trehalose, turns round thorn celestial being at 2 parts of tranexamic acid People slaps 1 part of stem extraction, 0.5 part of tapioca, 0.1 part of sodium hydroxide, 5 parts of fibronectin.
3. a kind of customize cleawhite over-night essences preparation method based on private gene as claimed in claim 1 or 2, which is characterized in that Raw material proportioning is carried out according to private genetic test, raw material components are made by formula, comprising the following steps:
(1) by deionized water, two glycerol, acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 cross-linked polymer, glycerol, poly- Sodium acrylate, Sodium Hyaluronate, disodium ethylene diamine tetraacetate, parahydroxyacet-ophenone, decoyl hydroximic acid, niacinamide, is dashed forward at butanediol It faints rose water, Gotu Kola P.E, succinic acid diethoxy ethyl ester, tranexamic acid, dried tremella extract, tremella polysaccharides, seaweed Sugar, torsion thorn Cactus Pedicel extract, tapioca, sodium hydroxide, fibronectin have been weighed spare by formulation weight part;
(2) by acrylic acid (ester) alkylol acrylamide acid esters of class/C10~30 cross-linked polymer, Sodium Polyacrylate, Sodium Hyaluronate, two Glycerol, glycerol, butanediol, disodium ethylene diamine tetraacetate, parahydroxyacet-ophenone, 50~80 parts of deionized waters are heated to 80~85 DEG C, homogeneous uniform, dissolution obtain mixed solution completely, and mixed solution is kept the temperature 3 minutes;
(3) when mixed solution is cooled to 60 DEG C, succinic acid diethoxy ethyl ester, pre-dispersed good with remaining deionized water is added Niacinamide and tranexamic acid, be uniformly mixing to obtain new mixed solution;
(4) when new mixed solution is cooled to 45 DEG C, Tujue rose water, Gotu Kola P.E, dried tremella extract, silver is added Fungus polysaccharides, trehalose, torsion thorn Cactus Pedicel extract, tapioca, sodium hydroxide, fibronectin are stirred evenly and be can be obtained into Product.
4. as claimed in claim 3 customize cleawhite over-night essences preparation method based on private gene, which is characterized in that step (2) In the deionized water number be 55 parts.
CN201811574913.9A 2018-12-21 2018-12-21 One kind is based on private gene customization cleawhite over-night essences and preparation method thereof Withdrawn CN109528587A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110302064A (en) * 2019-07-26 2019-10-08 嘉兴言肌草生物技术有限公司 A kind of skin whitening, moisturizing Essence and the whitening moisturizing face masque using its preparation
CN110664698A (en) * 2019-11-21 2020-01-10 樊瑞 Composition with whitening effect and preparation method thereof
CN113398031A (en) * 2021-07-09 2021-09-17 广州颜芝堡化妆品有限公司 Multifunctional mask liquid and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110302064A (en) * 2019-07-26 2019-10-08 嘉兴言肌草生物技术有限公司 A kind of skin whitening, moisturizing Essence and the whitening moisturizing face masque using its preparation
CN110302064B (en) * 2019-07-26 2022-06-07 嘉兴言肌草生物技术有限公司 Whitening and moisturizing essence and whitening and moisturizing mask prepared from same
CN110664698A (en) * 2019-11-21 2020-01-10 樊瑞 Composition with whitening effect and preparation method thereof
CN113398031A (en) * 2021-07-09 2021-09-17 广州颜芝堡化妆品有限公司 Multifunctional mask liquid and preparation method thereof

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