CN109528535A - 用于光稳定丁基甲氧基二苯甲酰基甲烷的防晒剂的组合物和组合 - Google Patents
用于光稳定丁基甲氧基二苯甲酰基甲烷的防晒剂的组合物和组合 Download PDFInfo
- Publication number
- CN109528535A CN109528535A CN201811197157.2A CN201811197157A CN109528535A CN 109528535 A CN109528535 A CN 109528535A CN 201811197157 A CN201811197157 A CN 201811197157A CN 109528535 A CN109528535 A CN 109528535A
- Authority
- CN
- China
- Prior art keywords
- weight
- composition
- bmdbm
- bemt
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 81
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 title claims abstract description 60
- 229960005193 avobenzone Drugs 0.000 title claims abstract description 60
- 239000000516 sunscreening agent Substances 0.000 title abstract description 10
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229960004101 bemotrizinol Drugs 0.000 claims abstract description 35
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 claims abstract description 18
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960003055 bisoctrizole Drugs 0.000 claims abstract description 11
- 239000002537 cosmetic Substances 0.000 claims abstract description 9
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229960000601 octocrylene Drugs 0.000 claims abstract description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 7
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 40
- -1 Diethylhexyl Butamido Chemical group 0.000 claims description 11
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 11
- 230000003711 photoprotective effect Effects 0.000 claims description 9
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims description 6
- 239000004305 biphenyl Substances 0.000 claims description 6
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 claims description 6
- 229960000655 ensulizole Drugs 0.000 claims description 6
- 229940068171 ethyl hexyl salicylate Drugs 0.000 claims description 6
- HRGXTYVIVADAHN-UHFFFAOYSA-N 5-methoxy-4-phenyltriazine;phenol Chemical compound OC1=CC=CC=C1.COC1=CN=NN=C1C1=CC=CC=C1 HRGXTYVIVADAHN-UHFFFAOYSA-N 0.000 claims description 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims 1
- VTQVLCXOOIFPBB-UHFFFAOYSA-N 4-ethyl-5-hexyl-1H-triazin-6-one Chemical compound C(C)C1=C(C(NN=N1)=O)CCCCCC VTQVLCXOOIFPBB-UHFFFAOYSA-N 0.000 claims 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 210000003491 skin Anatomy 0.000 description 9
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000001228 spectrum Methods 0.000 description 6
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 description 5
- 229960004050 aminobenzoic acid Drugs 0.000 description 5
- 230000000475 sunscreen effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000001993 wax Substances 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- YUXBNNVWBUTOQZ-UHFFFAOYSA-N 4-phenyltriazine Chemical compound C1=CC=CC=C1C1=CC=NN=N1 YUXBNNVWBUTOQZ-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 229960004881 homosalate Drugs 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 238000001259 photo etching Methods 0.000 description 2
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- LCZVSXRMYJUNFX-UHFFFAOYSA-N 2-[2-(2-hydroxypropoxy)propoxy]propan-1-ol Chemical compound CC(O)COC(C)COC(C)CO LCZVSXRMYJUNFX-UHFFFAOYSA-N 0.000 description 1
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- NCIAZCLIFWUDPR-UHFFFAOYSA-N 2-butyl-3,4,5,6-tetramethylphenol Chemical compound CCCCC1=C(C)C(C)=C(C)C(C)=C1O NCIAZCLIFWUDPR-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 239000001836 Dioctyl sodium sulphosuccinate Substances 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 238000001720 action spectrum Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012042 active reagent Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000012164 animal wax Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000578 anorexic effect Effects 0.000 description 1
- 239000000058 anti acne agent Substances 0.000 description 1
- 229940124340 antiacne agent Drugs 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- 150000007516 brønsted-lowry acids Chemical class 0.000 description 1
- 150000007528 brønsted-lowry bases Chemical class 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- OVSVTCFNLSGAMM-KGBODLQUSA-N cis-phytofluene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/C=C/C=C(C)/CCC=C(/C)CCC=C(C)C)C)C)C)C OVSVTCFNLSGAMM-KGBODLQUSA-N 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 description 1
- 229960005215 dichloroacetic acid Drugs 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 229940043237 diethanolamine Drugs 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000007046 ethoxylation reaction Methods 0.000 description 1
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003682 fluorination reaction Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- OVSVTCFNLSGAMM-UZFNGAIXSA-N phytofluene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=C\C=C(/C)\C=C\C=C(C)CCC=C(C)CCC=C(C)C OVSVTCFNLSGAMM-UZFNGAIXSA-N 0.000 description 1
- 235000002677 phytofluene Nutrition 0.000 description 1
- ZYSFBWMZMDHGOJ-SGKBLAECSA-N phytofluene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)C=CC=C(/C)CCC=C(C)C)C)C)C)C ZYSFBWMZMDHGOJ-SGKBLAECSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000006254 rheological additive Substances 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- ZIUDAKDLOLDEGU-UHFFFAOYSA-N trans-Phytofluen Natural products CC(C)=CCCC(C)CCCC(C)CC=CC(C)=CC=CC=C(C)C=CCC(C)CCCC(C)CCC=C(C)C ZIUDAKDLOLDEGU-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 229940061629 trideceth-9 Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
本发明涉及用于光稳定丁基甲氧基二苯甲酰基甲烷的防晒剂的组合物和组合。具体地,本发明涉及一种含有丁基甲氧基二苯甲酰基甲烷(BMDBM)、双‑乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和亚甲基双‑苯并三唑基四甲基丁基苯酚(MBBT)的经光稳定化的组合和药物可接受或化妆品可接受的赋形剂的组合物,其中:(i)‑BEMT/BMDBM质量比大于或等于1,且优选大于或等于1.5;(ii)‑所含BMDBM的含量以组合物的总重量计在1重量%和5重量%之间;(iii)‑所含MBBT的量以组合物的总重量计在3重量%和7重量%之间,所述组合不含氰双苯丙烯酸辛酯、PABA或乙基己基甲氧基肉桂酸酯。
Description
本申请是申请号为201380007218.3,申请日为2013年01月30日,发明名称为“用于光稳定丁基甲氧基二苯甲酰基甲烷(BMDBM)的防晒剂的组合物和组合”的中国专利申请的分案申请。
技术领域
本发明涉及一种用于丁基甲氧基二苯甲酰基甲烷(BMDBM)的光稳定的防晒剂的组合。
背景技术
对抗UVA(320-400nm)的保护必须实质上限制与可导致皮肤的变化、光老化的加速、皮肤弹性的损失等的长时暴露相关的损害。
首先,回顾本发明的范围中涉及的主要滤光剂的命名和缩写:
-丁基甲氧基二苯甲酰基甲烷(BMDBM)=阿伏苯宗=CAS注册号:70356-09-1,所述滤光剂以DSM商标销售,
-2,4-双[4-(2-乙基己氧基)-2-羟基苯基]-6-(4-甲氧基苯基)-1,3,5-三嗪=双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)=Bemotrizinol=CAS注册号:187393-00-6,所述滤光剂以BASF商标Tinosorb 销售,
-2,2'-亚甲基-双-(6-(2H-苯并三唑-2-基)-4-(1,1,3,3-四甲基丁基)-苯酚=亚甲基双-苯并三唑基四甲基丁基苯酚(MBBT)=Bisoctrizole=CAS注册号:103597-45-1,所述滤光剂以BASF商标Tinosorb 销售。
丁基甲氧基二苯甲酰基甲烷(BMDBM)不是UV辐射稳定滤光剂。分子发生分裂,其分解成不具有吸收剂活性的各种化学元素。
当与其他滤光剂(例如乙基己基甲氧基肉桂酸酯)组合时,BMDBM仍然可分解并损失其光防护性质。
BMDBM通常与使其光稳定的氰双苯丙烯酸辛酯,或甚至PABA(对氨基苯甲酸)组合。然而,氰双苯丙烯酸辛酯具有这样的缺陷:其作为强大的变应原,在儿童中导致接触性湿疹,并与酮洛芬交叉过敏。
最近,现有技术包括文献US20110212040,所述文献教导了通过添加合成或天然八氢番茄红素或六氢番茄红素而稳定BMDBM。
本发明的目的在于提供用于光稳定BMDBM,并同时根据目前的规定而开发光防护体系的新的替代方案。
发明内容
本发明涉及一种含有丁基甲氧基二苯甲酰基甲烷(BMDBM)、双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和亚甲基双-苯并三唑基四甲基丁基苯酚(MBBT)的组合,其特征在于:
-BEMT/BMDBM质量比大于或等于1,且优选大于或等于1.5,且
-所述组合不含有氰双苯丙烯酸辛酯。
本发明涉及一种含有丁基甲氧基二苯甲酰基甲烷(BMDBM)、双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和亚甲基双-苯并三唑基四甲基丁基苯酚(MBBT)的经光稳定化的组合和药物可接受或化妆品可接受的赋形剂的组合物,其中:
i.BEMT/BMDBM质量比大于或等于1,且优选大于或等于1.5,且
ii.所含BMDBM的含量以组合物的总重量计在1重量%和5重量%之间,
iii.所含MBBT的量以组合物的总重量计在3重量%和7重量%之间,
所述组合不含氰双苯丙烯酸辛酯、PABA或乙基己基甲氧基肉桂酸酯。
在本发明的一个特定实施方案中,BEMT/BMDBM质量比小于或等于5,优选小于或等于4,甚至更优先小于或等于3。
优先地,BEMT/BMDBM质量比选择为在1至5,优先1.5至5,甚至更优先1.5至3的范围内。
根据本发明的另一特性,所含BEMT含量以组合物的总重量计在2重量%和6重量%之间。
在本发明的框架中,必须将BEMT/BMDBM质量比考虑为主要特性特征。这意味着必须在每个浓度比率内调节不同的太阳滤光剂BEMT、BMDBM和MBBT的浓度,以首先且最重要地遵守所述质量比例。
本发明的另一主题涉及一种含有BMDBM、BEMT和MBBT的组合的组合物,其特征在于:
-BEMT/BMDBM质量比大于或等于1,且优选大于或等于1.5,且
-所述组合不含有氰双苯丙烯酸辛酯,
-所含MBBT的量以组合物的总重量计在3重量%和7重量%之间,
-具有药物可接受或化妆品可接受的赋形剂。
本发明的另一主题涉及一种含有BMDBM、BEMT和MBBT的组合的组合物,其特征在于:
-BEMT/BMDBM质量比大于或等于1,且优选大于或等于1.5,
-所述组合不含氰双苯丙烯酸辛酯、PABA或乙基己基甲氧基肉桂酸酯。
-所含MBBT的量以组合物的总重量计在3重量%和7重量%之间,
-并具有药物可接受或化妆品可接受的赋形剂。
根据本发明的另一特性,如上组合物也具有含量以组合物的总重量计在2和6重量%之间的双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)。
根据本发明的另一特性,如上组合物也具有含量以组合物的总重量计在1和5重量%之间的丁基甲氧基二苯甲酰基甲烷(BMDBM)。
最后,根据本发明的另一特性,如上组合物也具有优选以组合物的总重量计在1和10重量%之间的另一滤光剂。
根据另一方面,本发明也涉及丁基甲氧基二苯甲酰基甲烷(BMDBM)、双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和亚甲基双-苯并三唑基四甲基丁基苯酚(MBBT)的组合在不存在氰双苯丙烯酸辛酯、PABA和乙基己基甲氧基肉桂酸酯的情况下用以光稳定光防护组合物中的BMDBM的用途,其中BEMT/BMDBM质量比大于或等于1,且优选大于或等于1.5。
“光稳定化、光稳定或光稳定性”就本发明的意义上说意指在照射5MED,优选10MED之后,保持如下:
-总SPF(290至400nm)的至少80%,优选至少85%,甚至更优先至少90%;和
-总SPF的UVA部分(320至400nm)的至少80%,优选至少85%,甚至更优先至少90%。
优选地,根据本发明的组合或组合物也不含
根据本发明的组合代表光稳定光防护体系,所述光稳定光防护体系组合完全且均匀分布于皮肤上的有机脂溶性滤光剂(如BMDBM和BEMT)以及分散于水相中以获得更好的吸收响应并因此获得更好的功效的有机防晒剂(如MBBT)。
优选地,调节根据本发明的组合物,以获得如下光防护体系:
-具有最广可能UV吸收光谱(290至400nm的最大光谱覆盖)
-遵守目前的规定,即具有大于或等于370nm的临界波长λc和小于或等于3的SPF/UVA比。
更优先地,根据本发明的组合物可对应于就防晒而言最大的类别,即具有SPF 50+。
可将如下UVB滤光剂中的一种或多种添加至根据本发明的组合物中:
●水杨酸酯:胡莫柳酯、乙基己基水杨酸酯
●苯基苯并咪唑磺酸
●乙基己基三嗪酮、二乙基己基丁酰胺基三嗪酮
●TiO2
●三-联苯三嗪。
如上所述的UVB滤光剂就耐受性、毒性、光稳定和UV吸收方面而言被认为是令人满意的UVB滤光剂。因此,作为有关胡莫柳酯的预防措施,优选地,优选如下一种或多种UVB滤光剂:
●乙基己基水杨酸酯
●苯基苯并咪唑磺酸
●乙基己基三嗪酮、二乙基己基丁酰胺基三嗪酮
●TiO2
●三-联苯三嗪。
此外,所述组合物优先对光、空气、湿气和温度稳定。
本发明的另一主题涉及一种含有经光稳定化的组合和药物可接受或化妆品可接受的赋形剂的组合物,所述经光稳定化的组合包含
-丁基甲氧基二苯甲酰基甲烷(BMDBM)、双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和亚甲基双-苯并三唑基四甲基丁基苯酚(MBBT),其中:
i.BEMT/BMDBM质量比大于或等于1,且优选大于或等于1.5,且
ii.所含的BMDBM的含量以组合物的总重量计在1重量%和5重量%之间,
iii.所含的MBBT的量以组合物的总重量计在3重量%和7重量%之间,
-另外,一种或多种UVB滤光剂选自如下滤光剂:
●乙基己基水杨酸酯
●苯基苯并咪唑磺酸
●乙基己基三嗪酮、二乙基己基丁酰胺基三嗪酮
●TiO2
●三-联苯三嗪。
在本发明的一个特定实施方案中,所含的一种或多种UVB滤光剂的量以组合物的重量计总共在1和10重量%之间。
在本发明的另一实施方案中,所述组合物含有以组合物的重量计1重量%至10重量%的量,优选以组合物的重量计1重量%至5重量%的量的单个另外的UVB滤光剂。
在本发明的一个特定实施方案中,所述组合物含有选自如下滤光剂的单个UVB滤光剂:
●乙基己基水杨酸酯
●苯基苯并咪唑磺酸
●乙基己基三嗪酮、二乙基己基丁酰胺基三嗪酮
●TiO2
●三-联苯三嗪
本发明最后涉及含有如下的组合用以光稳定光防护组合物中的BMDBM的用途:
-丁基甲氧基二苯甲酰基甲烷(BMDBM)、双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和亚甲基双-苯并三唑基四甲基丁基苯酚(MBBT),其中BEMT/BMDBM质量比大于或等于1,且优选大于或等于1.5,
-选自如下滤光剂的一种或多种UVB滤光剂,优选选自如下滤光剂的仅1种UVB滤光剂:
●乙基己基水杨酸酯
●苯基苯并咪唑磺酸
●乙基己基三嗪酮、二乙基己基丁酰胺基三嗪酮
●TiO2
●三-联苯三嗪。
“药物可接受的或化妆品可接受的赋形剂”意指用于制造、保存或施用所述组合物的任何佐剂或赋形剂。
根据本发明的组合物可更特别地为防晒组合物。它们特别地旨在保护皮肤(面部和/或身体)和/或毛发免于紫外辐射。
本发明也涉及一种用于保护皮肤(面部和/或身体)和/或毛发免于紫外辐射的方法,所述方法包括将之前描述的组合物施用至皮肤(面部和/或身体)和/或毛发上。
根据本发明的组合物也可包含特别地选自如下的常规化妆品或药物佐剂:脂肪、有机溶剂、增稠剂、软化剂、不透明剂、稳定剂、润肤剂、消泡剂、保湿剂、芳香剂、防腐剂、聚合物、填料、螯合剂、杀菌剂、气味吸收剂、碱化或酸化剂、表面活性剂、自由基清除剂、抗氧化剂、维生素E和C、α-羟基酸,或通常用于化妆品或药物中,特别是用于制造防晒组合物的任何其他成分。
脂肪可由油、蜡或它们的混合物组成,它们也可包括脂肪酸、脂肪醇和脂肪酸酯。油可选自动物油、植物油、矿物油或合成油,特别是凡士林油、石蜡油、挥发性或非挥发性硅油、异链烷烃、聚烯烃,和氟化及全氟化的油。同样地,蜡可选自动物蜡、地蜡、植物蜡或合成蜡,如蜂蜡、小烛树蜡、巴西棕榈蜡、石油蜡(或微晶蜡)、石蜡,和它们的混合物。
所述组合物还可包含在室温下(大约25℃)水可溶混的多元醇,所述多元醇特别地选自具有2至20个碳原子,优选具有2至10个碳原子,优选具有2至6个碳原子的多元醇,如甘油;二醇衍生物,如丙二醇、丁二醇、戊二醇、己二醇、二丙二醇和二乙二醇;二醇醚,如一丙二醇、二丙二醇或三丙二醇的C1-C4烷基醚、一乙二醇、二乙二醇或三乙二醇的C1-C4烷基醚,和它们的混合物。
所述组合物也可包含增稠剂或流变改性剂,例如非离子乙氧基化的疏水改性的氨基甲酸酯、聚羧酸增稠剂,如丙烯酸酯/硬脂醇聚醚20甲基丙烯酸酯共聚物、卡波姆(carbomer)、交联丙烯酸酯共聚物,和它们的混合物。
所述组合物也可包含酸和碱以调节所述组合物的pH区。碱可为无机的(氢氧化钠、氢氧化钾、氨等)或有机的,如单乙醇胺、二乙醇胺或三乙醇胺、氨基甲基丙二醇、N-甲基葡糖胺、碱性氨基酸(如精氨酸和赖氨酸),以及它们的混合物。
组合物也可包含皮肤调节剂。皮肤调节剂的例子包括但不限于阴离子、阳离子和非离子表面活性剂,如月桂基硫酸钠、二辛基磺基琥珀酸钠、硬脂酸钠、酯脱水山梨糖醇、乙氧基化的脂肪酸、乙氧基化的脂肪醇(如十三烷醇聚醚-9和PEG-5乙基己酸酯);本领域技术人员已知的任何其他乳化剂和调节剂,以及它们的混合物。
根据本发明的组合物还可包含特别地选自如下的另外的活性剂:保湿剂、剥离溶解剂(desquamating agent)、用于改进阻挡功能的试剂、脱色剂、抗氧化剂、皮肤紧致剂、抗糖化剂、刺激真皮和/或表皮大分子的合成和/或防止它们的降解的试剂、刺激成纤维细胞或角化细胞增殖和/或角化细胞分化的试剂、NO合成酶抑制剂、增加皮脂腺的活性的试剂、张力调节剂、脂肪重构剂(lipo-restructuring agents)、减肥剂(slimming agent)、促进皮肤微循环的试剂、安抚剂和/或刺激剂、皮脂调节或抗皮脂溢剂、收敛剂、伤口愈合剂、抗炎剂、抗痤疮剂,和它们的混合物。
根据本发明的组合物可以以用于局部施用(尤其是在皮肤和/或毛发上)的任何适当的形式呈现。特别地,它们可为通过将脂肪相分散于水相中而获得的乳状液(emulsion)的形式(例如一种或多种水包油或油包水乳状液),或为凝胶或无水液体、糊状或固体产品的形式,或为在小球的存在下的分散体的形式。根据本发明的组合物也可为更少的流体,并可为白色或有色霜剂、软膏、乳状物(milk)、乳液、浆液、糊剂、面膜、粉剂、固体棒或任选的气溶胶、泡沫或喷剂的形式。这些组合物也可为耐水的。
具体实施方式
评价总体UV和UVA光稳定性的体外方法
A)材料
-UV分光光度计:
分光光度计测量在表面上具有和不具有防晒组合物的层的情况下通过板的光谱透射率。
分光光度计应该允许在290nm和400nm之间的测量。为了降低测量读数之间的变化性,并弥补产品层的均匀性的缺乏,推荐的是位点的读数区域为至少0.5cm2。
用于这些测量的分光光度计为UV-1000S或2000S。
-板:
板为其上施用防晒组合物的材料。该材料必须对UV透明、非荧光的、光稳定的且相对于所测试的组合物的配混物为惰性的。对于此方案,聚甲基丙烯酸甲酯(PMMA)板经证实为理想的。
-UV源:
UV源为具有传播可见光+UVA+UVB光谱的氙弧灯的太阳模拟器。用于所述研究的UV源为Suntest CPS+(Atlas)
B)方法:
-测量通过未经处理的板的透射率:
首先,必须确定通过对照板的UV透射率。这通过铺展数微升甘油,从而完全覆盖板的表面而制得。
-样品施用:
将待测试的样品以1.3mg/cm2的量(保持在板上的实际量)施用至PMMA板上。为了确保量的准确性和结果的再现性,施用区域大于10cm2。
待测试的样品以分布于板的整个表面上的相同体积的大量小滴的形式施用。
为了确保产品的量正确,必须采用验证施用的产品的量的方法(例如:对在施用产品之前和之后板称量)。
在使用限定量的样品之后,应该尽可能快地(小于30秒)在整个板上铺展样品。
然后将样品置于室温下黑暗中15分钟,以促进形成均匀的膜。
-测量通过用样品处理的板的透射率:
使用分光光度计分析用样品处理的板,对于从290nm至400nm的每个波长,确定通过样品的UV辐射透射率的平均值(使用在板的不同区域上测得的单色吸光度数据)。
-测量次数:
对于每个样品,应该制备至少三个PMMA板。每个板应该在至少九个不同的区域中进行测量,除非几乎整个表面通过分光光度法测量。
C)光稳定性的计算:
来自用5和10MED的剂量照射之前和之后吸光度数据Α(λ)的体外SPF和UVA(PPD)的计算。
其中:
-E(λ)=红斑效力光谱
-S(λ)=太阳光谱辐照度
-Α(λ)=样品吸光度
-dλ=波长变化(1nm)
其中:
P(λ)=PPD作用光谱(持续性色素变黑)
I(λ)=太阳光谱辐照度
Α(λ)=样品吸光度
dλ=波长变化(1nm)
由下式计算光稳定性:
组合物实施例
组合物1
成分 | % |
丁基甲氧基二苯甲酰基甲烷 | 1-5 |
双-乙基己基氧基苯酚甲氧基苯基三嗪 | 2-6 |
亚甲基双-苯并三唑基四甲基丁基苯酚 | 3-7 |
甘油 | 10.0 |
脱矿质水 | QSP 100 |
Na2EDTA | 0.1 |
黄原胶 | 0.3 |
苯甲酸C12-C15烷基酯 | 25.0 |
防腐剂 | qs |
硬脂醇 | 2.5 |
单硬脂酸甘油酯 | 2.5 |
十六烷基磷酸钾 | 1.8 |
组合物2
成分 | % |
丁基甲氧基二苯甲酰基甲烷 | 1-5 |
双-乙基己基氧基苯酚甲氧基苯基三嗪 | 2-6 |
亚甲基双-苯并三唑基四甲基丁基苯酚 | 3-7 |
UVB滤光剂 | 1-10 |
甘油 | 10.0 |
脱矿质水 | QSP 100 |
Na2EDTA | 0.1 |
黄原胶 | 0.3 |
苯甲酸C12-C15烷基酯 | 25.0 |
防腐剂 | qs |
硬脂醇 | 2.5 |
单硬脂酸甘油酯 | 2.5 |
十六烷基磷酸钾 | 1.8 |
光稳定性结果
光稳定性: | 组合物1 | 组合物2 |
总UV-5MED | 96% | 93% |
UVA-5MED | 95% | 92% |
总UV-10MED | 92% | 90% |
UVA-10MED | 91% | 89% |
Claims (4)
1.一种组合物,其含有药物可接受或化妆品可接受的赋形剂和UV滤光剂的光稳定化的组合,所述UV滤光剂的光稳定化的组合由丁基甲氧基二苯甲酰基甲烷(BMDBM)、双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)、亚甲基双-苯并三唑基四甲基丁基苯酚(MBBT)和单个另外的UVB滤光剂组成,所述UVB滤光剂选自乙基己基水杨酸酯、苯基苯并咪唑磺酸、乙基己基三嗪酮、二乙基己基丁酰胺基三嗪酮、TiO2、和三-联苯三嗪,其中:
i)BEMT含量以组合物的总重量计在2重量%和6重量%之间,
ii)BMDBM的含量以组合物的总重量计在1重量%和5重量%之间,
iii)BEMT/BMDBM质量比大于或等于1.5,
iv)MBBT的量以组合物的总重量计在3重量%和7重量%之间,
v)单个另外的UVB滤光剂以组合物的重量计以总共1重量%至10重量%的量存在。
2.根据权利要求1所述的组合物,其特征在于,单个另外的UVB滤光剂以组合物的重量计以1重量%至5重量%的量存在。
3.根据权利要求1或2所述的组合物,其用作光防护体系。
4.丁基甲氧基二苯甲酰基甲烷(BMDBM)、双-乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和亚甲基双-苯并三唑基四甲基丁基苯酚(MBBT)的组合用以光稳定光防护组合物中的BMDBM的用途,其中:
i)BEMT含量以组合物的总重量计在2重量%和6重量%之间,
ii)BMDBM的含量以组合物的总重量计在1重量%和5重量%之间,
iii)BEMT/BMDBM质量比大于或等于1.5,
iv)MBBT的量以组合物的总重量计在3重量%和7重量%之间,
v)单个另外的UVB滤光剂以组合物的重量计以总共1重量%至10重量%的量存在,
所述组合物,不含有氰双苯丙烯酸辛酯、PABA和乙基己基甲氧基肉桂酸酯。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/FR2012/050202 WO2013114004A1 (fr) | 2012-01-31 | 2012-01-31 | Composition et association de filtres solaires photostabilisatrices de bmdbm |
FRPCT/FR2012/050202 | 2012-01-31 | ||
CN201380007218.3A CN104080437A (zh) | 2012-01-31 | 2013-01-30 | 用于光稳定丁基甲氧基二苯甲酰基甲烷(bmdbm)的防晒剂的组合物和组合 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380007218.3A Division CN104080437A (zh) | 2012-01-31 | 2013-01-30 | 用于光稳定丁基甲氧基二苯甲酰基甲烷(bmdbm)的防晒剂的组合物和组合 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109528535A true CN109528535A (zh) | 2019-03-29 |
Family
ID=47631430
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811197157.2A Pending CN109528535A (zh) | 2012-01-31 | 2013-01-30 | 用于光稳定丁基甲氧基二苯甲酰基甲烷的防晒剂的组合物和组合 |
CN201380007218.3A Pending CN104080437A (zh) | 2012-01-31 | 2013-01-30 | 用于光稳定丁基甲氧基二苯甲酰基甲烷(bmdbm)的防晒剂的组合物和组合 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380007218.3A Pending CN104080437A (zh) | 2012-01-31 | 2013-01-30 | 用于光稳定丁基甲氧基二苯甲酰基甲烷(bmdbm)的防晒剂的组合物和组合 |
Country Status (19)
Country | Link |
---|---|
US (1) | US9814660B2 (zh) |
EP (2) | EP3299009A1 (zh) |
JP (2) | JP6385283B2 (zh) |
KR (1) | KR102107864B1 (zh) |
CN (2) | CN109528535A (zh) |
AR (1) | AR089850A1 (zh) |
AU (1) | AU2013214294B2 (zh) |
BR (1) | BR112014018888B1 (zh) |
CA (1) | CA2863278C (zh) |
DK (1) | DK2809295T3 (zh) |
ES (1) | ES2658363T3 (zh) |
HK (2) | HK1200344A1 (zh) |
MX (1) | MX351047B (zh) |
NO (1) | NO2809295T3 (zh) |
PL (1) | PL2809295T3 (zh) |
PT (1) | PT2809295T (zh) |
RU (1) | RU2651451C2 (zh) |
TW (1) | TWI645859B (zh) |
WO (2) | WO2013114004A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3023718B1 (fr) * | 2014-07-16 | 2018-10-12 | Pierre Fabre Medicament | Compositions pharmaceutique et/ou cosmetique decontaminees par haute pression |
DE102015208855A1 (de) | 2015-05-13 | 2016-11-17 | Beiersdorf Ag | Octocrylenfreies Sonnenschutzmittel mit Diethylhexylbutanidotriazon |
JP6143914B2 (ja) * | 2015-09-30 | 2017-06-07 | 株式会社 資生堂 | 日焼け止め化粧料 |
KR20210072793A (ko) * | 2018-10-05 | 2021-06-17 | 바스프 에스이 | 직물 착색 감소를 위한 메틸렌 비스-벤조트리아졸릴 테트라메틸부틸페놀 |
FR3091816B1 (fr) * | 2019-01-18 | 2022-08-05 | Fabre Pierre Dermo Cosmetique | Dispositif pour la caractérisation et la comparaison de zones érythémales |
EP4176936A1 (en) | 2021-11-08 | 2023-05-10 | Martiderm, SL | Cosmetic composition for protecting the skin and hair against solar radiation |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6419908B1 (en) * | 1999-10-22 | 2002-07-16 | Societe L'oreal | UV-photostabilization of dibenzoylmethane sunscreens by compounding with micronized insoluble screening agents |
CN1406578A (zh) * | 2001-09-07 | 2003-04-02 | 巴斯福股份公司 | 包含氨基取代的羟基二苯甲酮的o/w乳液形式的化妆品和皮肤用制剂 |
JP2003532665A (ja) * | 2000-05-12 | 2003-11-05 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | ジベンゾイルメタン誘導体の光安定化 |
US20050013782A1 (en) * | 2001-12-20 | 2005-01-20 | Beiersdorf Ag | Cosmetic or dermatological light-protective formulation comprising a bisresorcinyl triazine derivative and a benzoxazole derivative |
CN101095648A (zh) * | 2006-06-23 | 2008-01-02 | 莱雅公司 | 含二苯甲酰甲烷衍生物和芳烷基酰胺或酯化合物的美容组合物及光稳定二苯甲酰甲烷衍生物方法 |
CN101267801A (zh) * | 2005-09-15 | 2008-09-17 | 考格尼斯知识产权管理有限责任公司 | 化妆用油物质 |
CN101365412A (zh) * | 2005-12-09 | 2009-02-11 | 帝斯曼知识产权资产管理有限公司 | 包含经修饰的二氧化钛颗粒的化妆品组合物或皮肤护理组合物 |
CN101711151A (zh) * | 2007-01-25 | 2010-05-19 | 西巴控股公司 | Uv-敏感活性成分的稳定作用 |
CN102186452A (zh) * | 2008-10-17 | 2011-09-14 | 巴斯夫欧洲公司 | 包含无规三元共聚物的防晒剂和个人护理组合物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002219804A1 (en) * | 2000-11-28 | 2002-06-11 | Avon Products Inc. | Water-in-oil insect repellent composition and method of application to the skin |
DE10063343A1 (de) | 2000-12-19 | 2002-06-20 | Beiersdorf Ag | Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an unsymmetrisch substitutierten Triazinderivaten und oberflächenaktiven Zitronensäureestern |
DE10135258A1 (de) * | 2001-07-19 | 2003-02-06 | Beiersdorf Ag | Insektenabwehrende Sonnenschutzmittel |
DE10154111A1 (de) * | 2001-11-03 | 2003-05-22 | Beiersdorf Ag | Insektenabwehrende Sonnenschutzmittel mit Benztriazolderivaten als Lichtschutzfilter |
DE10155963A1 (de) * | 2001-11-09 | 2003-05-22 | Beiersdorf Ag | Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Hydroxybenzophenonen, Triazin- und/oder Benzotriazol-Derivaten |
DE10307468A1 (de) | 2003-02-21 | 2004-09-02 | Beiersdorf Ag | Kosmetische und dermatologische Emulsionen |
DE10307467A1 (de) * | 2003-02-21 | 2004-09-02 | Beiersdorf Ag | Kosmetische und dermatologische Emulsionen |
EP1764081A1 (en) * | 2005-08-29 | 2007-03-21 | Johnson & Johnson Consumer France SAS | Sunscreen composition comprising a dibenzoylmethane, an aminohydroxybenzophenone, a triazine and a triazole as UV filters |
GB2439618A (en) * | 2006-06-14 | 2008-01-02 | Reckitt & Colmann Prod Ltd | Skincare composition |
US20110212040A1 (en) | 2010-02-28 | 2011-09-01 | Von Oppen Bezalel Lea | Stabilized sunscreen compositions |
-
2012
- 2012-01-31 WO PCT/FR2012/050202 patent/WO2013114004A1/fr active Application Filing
-
2013
- 2013-01-30 ES ES13702214.1T patent/ES2658363T3/es active Active
- 2013-01-30 EP EP17195513.1A patent/EP3299009A1/en active Pending
- 2013-01-30 US US14/375,731 patent/US9814660B2/en active Active
- 2013-01-30 PT PT137022141T patent/PT2809295T/pt unknown
- 2013-01-30 TW TW102103506A patent/TWI645859B/zh active
- 2013-01-30 AR ARP130100278A patent/AR089850A1/es active IP Right Grant
- 2013-01-30 CA CA2863278A patent/CA2863278C/en active Active
- 2013-01-30 CN CN201811197157.2A patent/CN109528535A/zh active Pending
- 2013-01-30 WO PCT/EP2013/051777 patent/WO2013113746A2/en active Application Filing
- 2013-01-30 CN CN201380007218.3A patent/CN104080437A/zh active Pending
- 2013-01-30 NO NO13702214A patent/NO2809295T3/no unknown
- 2013-01-30 RU RU2014133694A patent/RU2651451C2/ru active
- 2013-01-30 AU AU2013214294A patent/AU2013214294B2/en active Active
- 2013-01-30 PL PL13702214T patent/PL2809295T3/pl unknown
- 2013-01-30 JP JP2014555186A patent/JP6385283B2/ja active Active
- 2013-01-30 MX MX2014009263A patent/MX351047B/es active IP Right Grant
- 2013-01-30 BR BR112014018888A patent/BR112014018888B1/pt active IP Right Grant
- 2013-01-30 DK DK13702214.1T patent/DK2809295T3/en active
- 2013-01-30 EP EP13702214.1A patent/EP2809295B1/en not_active Revoked
- 2013-01-30 KR KR1020147023633A patent/KR102107864B1/ko active IP Right Grant
-
2015
- 2015-01-27 HK HK15100894.0A patent/HK1200344A1/zh unknown
-
2018
- 2018-04-19 JP JP2018080691A patent/JP2018135358A/ja active Pending
- 2018-09-21 HK HK18112246.7A patent/HK1252899A1/zh unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6419908B1 (en) * | 1999-10-22 | 2002-07-16 | Societe L'oreal | UV-photostabilization of dibenzoylmethane sunscreens by compounding with micronized insoluble screening agents |
JP2003532665A (ja) * | 2000-05-12 | 2003-11-05 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | ジベンゾイルメタン誘導体の光安定化 |
CN1406578A (zh) * | 2001-09-07 | 2003-04-02 | 巴斯福股份公司 | 包含氨基取代的羟基二苯甲酮的o/w乳液形式的化妆品和皮肤用制剂 |
US20050013782A1 (en) * | 2001-12-20 | 2005-01-20 | Beiersdorf Ag | Cosmetic or dermatological light-protective formulation comprising a bisresorcinyl triazine derivative and a benzoxazole derivative |
CN101267801A (zh) * | 2005-09-15 | 2008-09-17 | 考格尼斯知识产权管理有限责任公司 | 化妆用油物质 |
CN101365412A (zh) * | 2005-12-09 | 2009-02-11 | 帝斯曼知识产权资产管理有限公司 | 包含经修饰的二氧化钛颗粒的化妆品组合物或皮肤护理组合物 |
CN101095648A (zh) * | 2006-06-23 | 2008-01-02 | 莱雅公司 | 含二苯甲酰甲烷衍生物和芳烷基酰胺或酯化合物的美容组合物及光稳定二苯甲酰甲烷衍生物方法 |
CN101711151A (zh) * | 2007-01-25 | 2010-05-19 | 西巴控股公司 | Uv-敏感活性成分的稳定作用 |
CN102186452A (zh) * | 2008-10-17 | 2011-09-14 | 巴斯夫欧洲公司 | 包含无规三元共聚物的防晒剂和个人护理组合物 |
Non-Patent Citations (1)
Title |
---|
ERIC CHATELAIN,等: "Photostabilization of Butyl methoxydibenzoylmethane (Avobenzone) and Ethylhexyl methoxycinnamate by Bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a New UV Broadband Filter", 《PHOTOCHEMISTRY AND PHOTOBIOLOGY》 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104093395B (zh) | 光保护系统 | |
CN109528535A (zh) | 用于光稳定丁基甲氧基二苯甲酰基甲烷的防晒剂的组合物和组合 | |
JP7490674B2 (ja) | 4つの日焼け止め物質からなる光防護システム |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40006867 Country of ref document: HK |