CN109528349B - Novel small animal uterus perfusion device - Google Patents
Novel small animal uterus perfusion device Download PDFInfo
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- CN109528349B CN109528349B CN201910057553.3A CN201910057553A CN109528349B CN 109528349 B CN109528349 B CN 109528349B CN 201910057553 A CN201910057553 A CN 201910057553A CN 109528349 B CN109528349 B CN 109528349B
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- 241001465754 Metazoa Species 0.000 title claims abstract description 26
- 230000010412 perfusion Effects 0.000 title claims abstract description 25
- 210000004291 uterus Anatomy 0.000 title claims abstract description 16
- 229910000831 Steel Inorganic materials 0.000 claims abstract description 50
- 239000010959 steel Substances 0.000 claims abstract description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000002955 isolation Methods 0.000 claims abstract description 6
- 238000000926 separation method Methods 0.000 claims abstract 4
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims description 10
- 210000000754 myometrium Anatomy 0.000 claims description 7
- 239000003822 epoxy resin Substances 0.000 claims description 6
- 229920000647 polyepoxide Polymers 0.000 claims description 6
- 244000043261 Hevea brasiliensis Species 0.000 claims description 5
- 210000004696 endometrium Anatomy 0.000 claims description 5
- 239000000835 fiber Substances 0.000 claims description 5
- 229920003052 natural elastomer Polymers 0.000 claims description 5
- 229920001194 natural rubber Polymers 0.000 claims description 5
- 229920000728 polyester Polymers 0.000 claims description 5
- 229920003225 polyurethane elastomer Polymers 0.000 claims description 5
- 229920003023 plastic Polymers 0.000 claims description 3
- 238000010241 blood sampling Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 description 15
- 238000000034 method Methods 0.000 description 13
- 239000007788 liquid Substances 0.000 description 10
- 238000011160 research Methods 0.000 description 5
- 210000001215 vagina Anatomy 0.000 description 5
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 3
- 210000003679 cervix uteri Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 206010000050 Abdominal adhesions Diseases 0.000 description 1
- 208000004145 Endometritis Diseases 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010062233 Uterine infection Diseases 0.000 description 1
- 206010062662 Uterine mass Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000012779 reinforcing material Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L29/042—Rubbers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Surgical Instruments (AREA)
Abstract
The invention discloses a novel small animal uterus perfusion device, and belongs to the technical field of medical appliances. The novel small animal uterus perfusion device comprises a catheter, a three-way joint, an extension tube, a separation plug and a steel needle assembly, wherein one ends of the catheter and the extension tube are respectively connected with two interfaces of the three-way joint, the separation plug is arranged in the other interface of the three-way joint, a fixing device and a water stop clamp are arranged on the extension tube at intervals, the fixing device is movably connected with the extension tube, and one end of the extension tube far away from the three-way joint is also provided with an injector joint; the needle tip of the steel needle in the steel needle assembly penetrates through the isolation plug and is inserted into the catheter, and the steel needle is provided with a bulge. The invention can guide the catheter to reach the accurate position of the uterine cavity, has good adhesion with the tissue of the uterine cavity, has little return flow rate and small local damage to the uterus.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a novel small animal uterus perfusion device.
Background
According to experimental needs, particularly in research in the reproductive field, a method for clinically using medicines for uterine cavity perfusion on animals is required to be simulated or a disease model is constructed through uterine cavity perfusion, so that mechanism research related to the method is carried out. As the experimental animal commonly used at present, the uterine cavity of the rodent is narrow, the cervical orifice diameter is small, the single vagina double uterus double cervix is small, in the basic animal research at present, no method and device for effectively and simply simulating clinical uterine cavity perfusion are available, the related experiment needs to adopt the method of local uterine injection after the abdomen opening ligation of the distal uterine horn, the similar method can not completely simulate the clinical uterine perfusion, the local uterine injection damages endometrium and myometrium, the postoperative local uterine mass, infection and abdominal adhesion rate are higher, even the death rate of the animal is increased, the interference factors of scientific research are increased, and finally the experimental reliability is reduced.
At present, the related research usually adopts the method of injecting medicines into uterine cavities by puncturing myometrium through abdomen, and the method has the following defects: 1. the method of directly penetrating into the myometrium to be injected into the uterine cavity can not faithfully reproduce the clinical uterine cavity perfusion, and the modeling and treatment effects by using the method are unreliable. 2. The liquid medicine can flow to vagina after being injected from the uterine cavity, the distal uterine cavity needs to be ligated before the injection, the damage of uterus and surrounding vascular tissues is increased, and the postoperative local bleeding, edema, infection and uterine cavity adhesion can occur, so that the experimental effect is interfered. 3. By injecting the medicine liquid into the myometrium via the abdomen, the medicine liquid can seep from the injection point, the loss of the medicine is increased, and meanwhile, the medicine liquid extravasation increases the adhesion and pollution probability of the visceral organs of the abdominal cavity. Thus, there is a need to develop an effective device for uterine perfusion.
Disclosure of Invention
The invention aims at solving the problems and provides a novel small animal uterus perfusion device, wherein a catheter in the device can be well attached to uterine cavity tissues, and local damage is small; meanwhile, the puncture-proof hose cover can quickly adjust the steel needle in the catheter to an accurate position when the catheter is placed, so that endometrium and muscular layer are not damaged, and the catheter is continuously protected in the process of placing the catheter; the bulges on the steel needles are used as needle withdrawal marks and can be used for guiding the needle withdrawal to be accurately positioned so as to inject and pour the liquid medicine after the tube placement is successful.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
the utility model provides a novel small-size animal uterus perfusion device, includes pipe, three way connection, extension pipe, isolation plug and steel needle subassembly, the one end of pipe and extension pipe respectively with two of them interface connection of three way connection, the isolation plug is located in the another interface of three way connection, the interval is equipped with fixing device and stagnant water clamp on the extension pipe, fixing device with but extension pipe swing joint, the one end of extension pipe keep away from three way connection still is equipped with a syringe joint; the needle tip of the steel needle in the steel needle assembly penetrates through the isolation plug and is inserted into the catheter, and the steel needle is provided with a bulge.
Further, the steel needle assembly comprises a steel needle, a first needle seat and a second needle seat, wherein the first needle seat and the second needle seat are arranged at the end part, far away from the tip end of the needle, of the steel needle, the first needle seat is connected with the steel needle, the second needle seat is connected with the first needle seat, one end, far away from the steel needle, of the first needle seat is hung with an anti-puncture hose cover with an opening through a thin line, the anti-puncture hose cover is an elastic hose cover, the thin line is an elastic line, and a needle holding handle is arranged on the second needle seat.
Further, the three-way joint is a transparent plastic joint.
Further, the fixing device comprises a cable sleeve and a regular triangle base which are connected, and the cable sleeve is movably connected with the extension tube.
Further, the bottom of the regular triangle base is provided with a paste which can be used for fixing the extension tube on the operation table.
Further, the needle tip is triangular, and the needle holding handle is in a fin shape.
Further, the diameter of the first needle seat is smaller than the diameter of the second needle seat; the diameter of the first needle seat is 4-5mm, and the diameter of the second needle seat is 6-7mm; the diameter of the stab-resistant hose cover is 6-7mm, and the edge thickness is 3mm.
Further, the length of the catheter is 3.5-4cm, the diameter of the catheter is 1-1.5mm, and the length of the extension tube is 10cm.
Further, one end of the conduit far away from the three-way joint is an arc-shaped opening.
Further, the catheter is mainly prepared from the following components in parts by weight: 12-18 parts of natural rubber, 10-15 parts of polyester fiber, 5-10 parts of polyurethane elastomer, 3-7 parts of epoxy resin and 2-5 parts of dibutyl phthalate.
By adopting the technical scheme, the invention has the following beneficial effects:
1. the top end of the catheter is in an arc-shaped closing-up, so that the anatomical characteristics of narrow external orifice of the cervix of an animal can be overcome, the catheter insertion is easy to realize, and the local damage is small during the catheter insertion; the pipe diameter of the catheter is in high conformity with the pipe diameter of the animal, the catheter is not required to be fixed after being inserted, and meanwhile, no backflow of the liquid medicine is ensured. The length of the catheter is 3.5-4cm, which can just meet the distance requirement from the vagina to the cervical orifice, and simultaneously, can reduce the mechanical interference to the uterine cavity. In addition, the catheter material is soft and tough, can be well attached to uterine cavity tissues, and has small local damage.
2. The puncture-proof hose sleeve is used for fixing the steel needle to the accurate position in the catheter, so that the catheter can be better guided when the catheter is placed, and the endometrium and the myometrium are not damaged; the bulge on the steel needle is used as a needle withdrawal mark for guiding the needle withdrawal to be accurately positioned so as to inject and pour the liquid medicine after the tube placement is successful; the injector interface can be externally connected with various types of injectors and is used for injecting medicine; the water stop clamp can meet the requirement of pouring tension; the movable fixing device on the extension tube can be adhered to the operation table for fixing and supporting, preventing the device from falling off, and the like.
3. The invention is small and convenient, has low cost, can meet the requirement of routine experiment disinfection, improves the experiment efficiency, is simple and convenient to operate, can recover the liquid medicine through the external syringe after the pouring, and can be used for continuously acting after the liquid medicine is required to remain, and the catheter is pulled out rapidly due to the narrow cervical outer opening.
Drawings
FIG. 1 is a schematic structural view of a novel small animal uterus perfusion apparatus according to an embodiment of the present invention;
fig. 2 is a schematic structural view of a steel needle assembly in a novel small animal uterus perfusion apparatus according to an embodiment of the present invention.
In the drawings, a 1-catheter, a 2-three-way joint, a 3-extension tube, a 4-isolation plug, a 5-steel needle, a 6-fixing device, a 61-cable sleeve, a 62-regular triangle base, a 7-water stop clamp, an 8-syringe joint, a 9-bulge, a 10-first needle seat, a 11-second needle seat, a 12-puncture-proof hose sleeve, a 13-thin wire and a 14-needle holding handle are arranged.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When a component is considered to be "connected" to another component, it can be directly connected to the other component or intervening components may also be present. When an element is referred to as being "disposed on" another element, it can be directly on the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Examples
Referring to fig. 1 and 2, a novel small animal uterus perfusion device comprises a catheter 1, a tee joint 2, an extension tube 3, a isolating plug 4 and a steel needle assembly, wherein one ends of the catheter 1 and the extension tube 3 are respectively connected with two interfaces of the tee joint 2, and the isolating plug 4 is arranged in the other interface of the tee joint 2. The end of the catheter 1 far away from the three-way joint 2 is an arc-shaped opening, so that the invention can overcome the anatomical characteristic of narrow external opening of the cervix of an animal, the insertion of the catheter 1 is easy to realize, and the local damage to the catheter 1 during the insertion is small. The three-way joint 2 is a transparent plastic joint so as to facilitate observation and the like. The extension pipe 3 is provided with a fixing device 6 and a water stop clamp 7 at intervals, the fixing device 6 is movably connected with the extension pipe 3, and one end of the extension pipe 3 far away from the three-way joint 2 is also provided with a syringe joint 8. The needle tip of the steel needle 5 in the steel needle assembly is inserted into the catheter 1 through the isolating plug 4.
Further, the steel needle assembly comprises a steel needle 5, a first needle seat 10 and a second needle seat 11 which are arranged at the end part of the steel needle 5, which is far away from the tip of the needle, wherein the tip of the steel needle 5 protrudes in a triangle shape, a bulge 9 is arranged on the steel needle 5, the bulge 9 is used as a marking point for guiding the successful tube placement, and the needle withdrawal is accurately positioned so as to inject the infusion liquid medicine. The first needle seat 10 is connected with the steel needle 5, the second needle seat 11 is connected with one end of the first needle seat 10, which is far away from the steel needle 5, an anti-puncture hose cover 12 with an opening and a diameter of 6-7mm is hung on the first needle seat 10 through a thin wire 13, in this embodiment, the anti-puncture hose cover 12 is an elastic sleeve, the diameter of the anti-puncture hose cover 12 is 6mm, wherein the distance between the inner diameter and the outer diameter of the anti-puncture hose cover 12 is 1mm, the edge thickness of the anti-puncture hose cover 12 is 3mm (i.e. the distance between the opposite end surfaces of the anti-puncture hose cover 12), the thin wire 13 is an elastic wire, and a needle holding handle 14 is arranged on the second needle seat 11. The diameter of the first needle seat 10 is smaller than the diameter of the second needle seat 11; the diameter of the first needle seat 10 is 4-5mm, and the diameter of the second needle seat 11 is 6-7mm. In this embodiment, the diameter of the first needle holder 10 is 4mm, and the diameter of the second needle holder 11 is 6mm.
When the puncture-proof hose sleeve 12 is sleeved on the first needle seat 10, the puncture-proof hose sleeve 12 can be used for fixing the steel needle 5, so that an operator can quickly withdraw the steel needle 5 to an accurate position in the catheter 1 before placing a tube, and meanwhile, the steel needle 5 can be prevented from being mistakenly penetrated to damage endometrium and myometrium during operation. When the puncture-proof hose cover 12 is removed from the first needle seat 10, the first needle seat 10 can be completely anastomosed with a three-way joint and the like, and when the needle tip of the steel needle 5 protrudes outwards from the catheter, the puncture-proof hose cover can be used as an indwelling needle for arterial and venous blood sampling of animals, thereby achieving a multi-purpose way.
Further, the fixing device 6 includes a cable bush 61 and a regular triangle base 62 connected with each other, the cable bush 61 is movably connected with the extension tube 3, and an adhesive for fixing the extension tube 3 on the operation table is provided at the bottom of the regular triangle base 62.
Further, the needle holder 14 is of a fin-shaped shape, and the fin-shaped needle holder 14 is not only held by hand, but also does not interfere with the use of the puncture-preventing hose cover 12, and facilitates the placement of the catheter (i.e., the placement of the catheter 1).
Further, the length of the catheter 1 is 3.5-4cm, the diameter of the catheter 1 is 1-1.5mm, the distance requirement from the vagina to the cervical orifice and the size requirement of the cervical orifice can be just met, and meanwhile, the mechanical interference to the uterine cavity can be reduced. In this embodiment, the length of the catheter 1 is preferably 3.5cm, and the diameter of the catheter 1 is preferably 1mm. The length of the extension pipe 3 is 10cm to facilitate the installation, movement of the fixing device 6, installation of the water stop clamp 7, etc.
Further, the catheter 1 is mainly prepared from the following components in parts by weight: 12-18 parts of natural rubber, 10-15 parts of polyester fiber, 5-10 parts of polyurethane elastomer, 3-7 parts of epoxy resin and 2-5 parts of dibutyl phthalate. The natural rubber has good flexibility and elasticity, the polyester fiber can be used as a reinforcing material, the addition of the polyurethane elastomer further enhances the elasticity and strength of the rubber, the epoxy resin has good bonding effect, and a certain amount of dibutyl phthalate can enhance the viscosity of the epoxy resin, so that the catheter 1 is high in softness, good in elasticity and strong in toughness by adopting the materials, can be better attached to uterine cavity tissues, and has small local damage to uterus. In this embodiment, the catheter 1 is mainly made of the following components in parts by weight: 16 parts of natural rubber, 12 parts of polyester fiber, 8 parts of polyurethane elastomer, 5 parts of epoxy resin and 3 parts of dibutyl phthalate. The method of manufacturing the catheter 1 is the same as that of a general tube and will not be repeated here. In other embodiments, the puncture resistant hose cover 12 may be made of the same material as the catheter 1.
The application method of the device comprises the following steps: pulling the steel needle outwards, sleeving the anti-puncture tube sleeve on the small needle seat, adjusting the distance appropriately, and checking that the needle tip is retracted into the catheter by about 1-1.5 mm; the method comprises the steps of placing a steel needle into a vagina, simultaneously gently exploring the external cervical orifice with the top end of a catheter and leading the cervical orifice to enter along the trend, maintaining the top end of the catheter at the joint of two uterine angles, slightly pulling out the steel needle to a bulge (mark) on a needle body, adjusting and fixing an extension tube fixing device to prevent the device from falling off, and externally connecting a syringe with a syringe interface and injecting liquid medicine to realize the perfusion of the uterus. During this process, the (jaw) water stop clamp can be adjusted according to the experimental needs to maintain the uterine filling tension.
The foregoing description is directed to the preferred embodiments of the present invention, but the embodiments are not intended to limit the scope of the invention, and all equivalent changes or modifications made under the technical spirit of the present invention should be construed to fall within the scope of the present invention.
Claims (8)
1. A novel small animal uterus perfusion device, which is characterized in that: the three-way joint comprises a guide pipe, a three-way joint, an extension pipe, a separation plug and a steel needle assembly, wherein one end of the guide pipe and one end of the extension pipe are respectively connected with two interfaces of the three-way joint, the separation plug is arranged in the other interface of the three-way joint, a fixing device and a water stop clamp are arranged on the extension pipe at intervals, the fixing device is movably connected with the extension pipe, and one end, far away from the three-way joint, of the extension pipe is also provided with an injector joint; the needle tip of the steel needle in the steel needle assembly penetrates through the isolation plug and is inserted into the catheter, and the steel needle is provided with a bulge;
the steel needle assembly comprises a steel needle, a first needle seat and a second needle seat, wherein the first needle seat and the second needle seat are arranged at the end part, far away from the tip end of the needle, of the steel needle, the first needle seat is connected with the steel needle, the second needle seat is connected with one end, far away from the steel needle, of the first needle seat, an anti-puncture hose cover with an opening is hung on the first needle seat through a thin wire, the anti-puncture hose cover is an elastic hose cover, the thin wire is an elastic wire, and a needle holding handle is arranged on the second needle seat;
when the puncture-proof hose sleeve is sleeved on the first needle seat, the puncture-proof hose sleeve can be used for fixing the steel needle, so that an operator can quickly withdraw the steel needle to an accurate position in the catheter before placing the catheter, and meanwhile, the steel needle can be prevented from being mistakenly penetrated to damage endometrium and myometrium during operation; when the puncture-proof hose cover is removed from the first needle seat, the first needle seat can be completely anastomosed with the three-way joint, and when the needle tip of the steel needle protrudes outside the catheter, the puncture-proof hose cover can be used as an indwelling needle for arterial and venous blood sampling of animals;
the fixing device comprises a cable sleeve and a regular triangle base which are connected, and the cable sleeve is movably connected with the extension tube.
2. The novel small animal uterine perfusion device of claim 1, wherein: the three-way joint is a transparent plastic joint.
3. The novel small animal uterine perfusion device of claim 1, wherein: the bottom of the regular triangle base is provided with a paste which can be used for fixing the extension tube on the operation table.
4. The novel small animal uterine perfusion device of claim 2, wherein: the needle tip of the steel needle is triangular, and the needle holding handle is a fish-ridge fin.
5. The novel small animal uterine perfusion device of claim 2, wherein: the diameter of the first needle seat is smaller than that of the second needle seat; the diameter of the first needle seat is 4-5mm, and the diameter of the second needle seat is 6-7mm; the diameter of the stab-resistant hose cover is 6-7mm, and the edge thickness is 3mm.
6. The novel small animal uterine perfusion device of claim 1, wherein: the length of the conduit is 3.5-4cm, the diameter of the conduit is 1-1.5mm, and the length of the extension tube is 10cm.
7. The novel small animal uterine perfusion device of claim 1, wherein: one end of the conduit far away from the three-way joint is an arc-shaped opening.
8. The novel small animal uterine perfusion device of claim 1, wherein: the catheter is mainly prepared from the following components in parts by weight: 12-18 parts of natural rubber, 10-15 parts of polyester fiber, 5-10 parts of polyurethane elastomer, 3-7 parts of epoxy resin and 2-5 parts of dibutyl phthalate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910057553.3A CN109528349B (en) | 2019-01-22 | 2019-01-22 | Novel small animal uterus perfusion device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910057553.3A CN109528349B (en) | 2019-01-22 | 2019-01-22 | Novel small animal uterus perfusion device |
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| CN109528349A CN109528349A (en) | 2019-03-29 |
| CN109528349B true CN109528349B (en) | 2024-02-20 |
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| CN115191363B (en) * | 2022-07-12 | 2023-05-26 | 广西医科大学第一附属医院 | Joint movement testing system and method for experimental animals |
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