CN108938137A - Transurethral bladder communication apparatus - Google Patents
Transurethral bladder communication apparatus Download PDFInfo
- Publication number
- CN108938137A CN108938137A CN201810666493.0A CN201810666493A CN108938137A CN 108938137 A CN108938137 A CN 108938137A CN 201810666493 A CN201810666493 A CN 201810666493A CN 108938137 A CN108938137 A CN 108938137A
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- CN
- China
- Prior art keywords
- cushion chamber
- medicine cavity
- communication apparatus
- bottom end
- animal
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/061—Bladder and/or urethra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Radiation-Therapy Devices (AREA)
- Laser Surgery Devices (AREA)
Abstract
The present invention is a kind of transurethral bladder communication apparatus, it is characterized in that, connection main body includes cushion chamber and to medicine cavity, the cushion chamber top is connect with animal catheter, bottom end is arranged cushion chamber and blocks rubber plug, the cushion chamber blocks rubber plug and centre bore is arranged, the cushion chamber annular wall is connect with connector bottom end, the connector top and one end of administration siphunculus are tightly connected, the other end is connect with the end sealing to medicine cavity, the bottom end to medicine cavity, which is arranged to block to medicine cavity, fills in, inner core includes metal inside, pedestal and handle, the pedestal is connected and fixed with the handle, a through-hole is arranged in the pedestal, the bottom end of the metal inside is inserted and fixed in through-hole, the present invention provides a kind of minimally invasive per urethras for the communication apparatus of perfusion solution and post laser irradiation treatment in laboratory animal, reach safety, have Effect and minimally invasive purpose.
Description
Technical field
The present invention relates to a kind of transurethral bladder communication apparatus, the experimental provision for animal's bladder basic research.
Background technique
At present for the research of bladder disease, scientific research personnel tests often through the animal model for establishing corresponding disease
And research, need for the biological agents such as drug and cell to be injected into the bladder of animal in experimentation, observe inflammation in bladder,
For the treatment condition of related disease, the research of biomaterial accelerates auxiliary experimental equipment for the formation and development of tumour and drug
Research and development, most biological materials, especially nano material its biological action of competence exertion only under laser irradiation is former
Reason is that the drug with light thermal property is generated photodynamic reaction after laser active, produces highly active singlet oxygen, singlet oxygen
Oxidation reaction occurs with adjacent large biological molecule, generates oxidation toxicity effect, and then leads to bacterium or cell damage or even dead
It dies, and adjacent tissue is not affected, but near-infrared laser penetration into tissue has certain limitation (penetration range
8mm), therefore most of material can be only applied to body surface disease, such as skin disease, skin neoplasin, and which greatly limits its experiments
With application study, bladder directly communicates because it passes through urethra with the external world, has natural dissection advantage, can clinically pass through urine
To drugs irrigation of bladder and by laser radiation, excitation biology performance achievees the purpose that treatment in turn in road, but at present
There has been no a kind of minimally invasive only urethra instruments for the communication apparatus of drug infusion and laser radiation in laboratory animal.
Summary of the invention
The object of the present invention is to provide a kind of transurethral bladder communication apparatus, warp minimally invasive there has been no one kind at present is solved
Urethra device, for drug infusion and laser irradiation in laboratory animal.
To achieve the above object, the technical solution adopted by the present invention:
A kind of transurethral bladder communication apparatus characterized by comprising connection main body and inner core；
The connection main body includes cushion chamber and connects to medicine cavity, cushion chamber top end surface center and animal catheter
It connects, the cushion chamber bottom end setting cushion chamber blocks rubber plug, and the cushion chamber blocks rubber plug central point and centre bore is arranged, described slow
It rushes chamber angular wall surfaces to connect with connector bottom end, one end of the connector top and administration siphunculus is tightly connected, described to give
The other end of medicine siphunculus is connect with the end sealing to medicine cavity, and the bottom end to medicine cavity, which is arranged to block to medicine cavity, fills in；
The inner core includes metal inside, pedestal and handle, and the pedestal is in cylinder type, outer surface and the handle
It is connected and fixed, a through-hole is arranged in the top end surface center of circle of the pedestal, and the bottom end of the metal inside is inserted and fixed in logical
In hole；
The top of the metal inside passes through the centre bore and is inserted into the animal catheter, the metal inside top
End is flushed with animal catheter top.
The transurethral bladder communication apparatus, in which: laser fiber pass through the centre bore, the animal catheter and
Urethra is inserted into bladder, and laser is irradiated in the front end of the laser fiber.
The transurethral bladder communication apparatus, in which: the steel needle of syringe passes through described block to medicine cavity and fills in and be inserted into
The administration is intracavitary, for the intracavitary injection medical fluid of administration.
The transurethral bladder communication apparatus, in which: anti-skid bulge object is arranged in the handle both side surface.
The beneficial effects of the present invention are: compared to the operation of abdomen bladder is opened, the present invention can not only be crossed and is effectively reduced in experimentation
The wound of animal simultaneously reduces postoperative death rate, saves experimental cost, improves conventional efficient, while being able to ascend therapeutic effect, and
The dosage that can control the dabbling drug into animal's bladder achievees the purpose that safely, effectively and minimally invasive.
Detailed description of the invention
Fig. 1 is transurethral bladder communication apparatus combination assumption diagram.
Fig. 2 is transurethral bladder communication apparatus decomposition chart.
Fig. 3 is that transurethral bladder communication apparatus carries out laser irradiation structure chart in bladder.
Description of symbols: 1- is connected to main body；2- inner core；3- animal catheter；4- cushion chamber；5- cushion chamber blocks glue
Plug；6- centre bore；Communicating pipe is administered in 7-；8- is to medicine cavity；9- is blocked to medicine cavity to be filled in；10- metal inside；11- pedestal；12- handle；
13- anti-skid bulge；14 laser fibers；15- syringe；16- urethra；17- laser；18- bladder；19- connector.
Specific embodiment
A kind of transurethral bladder communication apparatus as shown in Figure 1, Figure 2 and Figure 3 characterized by comprising connection main body 1 and interior
Core 2.
The connection main body 1 is including cushion chamber 4 and gives medicine cavity 8, the 4 top end surface center of cushion chamber and animal catheter
3 connections, 4 bottom end of the cushion chamber setting cushion chamber block rubber plug 5, and the cushion chamber blocks 5 central point of rubber plug and centre bore is arranged
6,4 angular wall surfaces of cushion chamber are connect with 19 bottom end of connector, and 19 top of connector and one end of administration siphunculus 7 are close
The other end of envelope connection, the administration siphunculus 7 is connect with the end sealing to medicine cavity 8, and administration is arranged in the bottom end to medicine cavity 8
Chamber blocks plug 9.
The inner core 2 includes metal inside 10, pedestal 11 and handle 12, and the pedestal 11 is in cylinder type, outer surface
It is connected and fixed with the handle 12, a through-hole, the bottom of the metal inside 10 is arranged in the top end surface center of circle of the pedestal 11
End is inserted and fixed in through-hole.
The top of the metal inside 10 passes through the centre bore 6 and is inserted into the animal catheter 3, in the metal
10 top of core is flushed with 3 top of animal catheter.
Laser fiber 14 passes through the centre bore 6, the animal catheter 3 and urethra 16, is inserted into bladder 18, described to swash
Laser 17 is irradiated in the front end of light optical fiber 14.
The steel needle of syringe 15 blocks described in plug 9 and insertion to medicine cavity in medicine cavity 8 across described, gives medicine cavity 8 for described
Interior injection medical fluid.
Anti-skid bulge object 13 is arranged in 12 both side surface of handle.
The top of metal inside 10 described in embodiment passes through the centre bore 6 and is inserted into the animal catheter 3, institute
It states 10 top of metal inside to flush with 3 top of animal catheter, and passes through urethra 16 together, be inserted into bladder 18, laser
Optical fiber 14 passes through the centre bore 6, the animal catheter 3 and urethra 16, is inserted into bladder 18, before the laser fiber 14
End irradiation laser 17 holds the handle 12 after the laser fiber 14 is inserted into bladder 18, the inner core 2 from described
It is exited in animal catheter 3 and the cushion chamber 4, the steel needle of syringe 15 passes through described block to medicine cavity and fills in described in 9 and insertion
To in medicine cavity 8, for described to medical fluid is injected in medicine cavity 8, medical fluid enters the cushion chamber 4 by the administration communicating pipe 7, and leads to
It crosses the animal catheter to enter in the bladder 18, drug irradiation of the front end of the laser fiber 14 into the bladder 18
The laser 17, the drug with light thermal property are generated photodynamic reaction after the laser 17 activation, are produced highly active
Singlet oxygen, and then achieve the purpose that treatment.
Advantages of the present invention:
Compared to the operation of abdomen bladder is opened, the present invention, which can not only cross, to be effectively reduced the wound of animal in experimentation and reduces postoperative
The death rate saves experimental cost, improves conventional efficient, while being able to ascend therapeutic effect, and can control and fill into animal's bladder
The dosage of injection object achievees the purpose that safely, effectively and minimally invasive.
Described above to be merely exemplary for the purpose of the present invention, and not restrictive, those of ordinary skill in the art understand,
Without departing from the spirit and scope defined by the claims, can many modifications may be made, variation or equivalent, but will all fall
Enter within protection scope of the present invention.
Claims (4)
1. a kind of transurethral bladder communication apparatus characterized by comprising connection main body (1) and inner core (2)；
The connection main body (1) includes cushion chamber (4) and to medicine cavity (8), and cushion chamber (4) the top end surface center is led with animal
Urinary catheter (3) connection, cushion chamber (4) the bottom end setting cushion chamber block rubber plug (5), and the cushion chamber blocks rubber plug (5) center
Point setting centre bore (6), cushion chamber (4) angular wall surfaces are connect with connector (19) bottom end, connector (19) top
End and one end of administration siphunculus (7) are tightly connected, and the other end of administration siphunculus (7) connects with the end sealing to medicine cavity (8)
It connects, the bottom end to medicine cavity (8), which is arranged, blocks plug (9) to medicine cavity；
The inner core (2) includes metal inside (10), pedestal (11) and handle (12), and the pedestal (11) is in cylinder type, outside
Side surface is connected and fixed with the handle (12), and a through-hole, the metal is arranged in the top end surface center of circle of the pedestal (11)
The bottom end of inner core (10) is inserted and fixed in through-hole；
The top of the metal inside (10) passes through the centre bore (6) and is inserted into the animal catheter (3), the metal
Inner core (10) top is flushed with animal catheter (3) top.
2. a kind of transurethral bladder communication apparatus as described in claim 1, it is characterised in that: laser fiber (14) passes through described
Centre bore (6), the animal catheter (3) and urethra (16), insertion bladder (18) is interior, and the front end of the laser fiber (14) is shone
Penetrate laser (17).
3. a kind of transurethral bladder communication apparatus as described in claim 1, it is characterised in that: the steel needle of syringe (15) passes through
It is described to block described in plug (9) and insertion to medicine cavity in medicine cavity (8), medicine cavity (8) interior injection medical fluid is given for described.
4. a kind of transurethral bladder communication apparatus as described in claim 1, it is characterised in that: handle (12) both side surface
It is arranged anti-skid bulge object (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810666493.0A CN108938137B (en) | 2018-06-25 | 2018-06-25 | Transurethral bladder communication device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810666493.0A CN108938137B (en) | 2018-06-25 | 2018-06-25 | Transurethral bladder communication device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108938137A true CN108938137A (en) | 2018-12-07 |
| CN108938137B CN108938137B (en) | 2021-02-23 |
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ID=64486875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810666493.0A Active CN108938137B (en) | 2018-06-25 | 2018-06-25 | Transurethral bladder communication device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108938137B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528349A (en) * | 2019-01-22 | 2019-03-29 | 广西医科大学第附属医院 | A kind of novel meiofauna uterine perfusion device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1623516A (en) * | 2003-12-06 | 2005-06-08 | 李黎波 | Light power therapy special puncture needle |
| CN101002698A (en) * | 2007-01-18 | 2007-07-25 | 郑成福 | Apparatus for treating prostate diseases, and its making method |
| CN201135707Y (en) * | 2007-01-15 | 2008-10-22 | 郑成福 | A device for treating prostatic disease and females urethra syndrome |
| CN201324233Y (en) * | 2008-09-12 | 2009-10-14 | 夏术阶 | Adjustable fiber urethrocystoscope |
| CN205759152U (en) * | 2016-04-20 | 2016-12-07 | 深圳市第二人民医院 | A kind of aciculiform optical dynamic therapy device |
| CN207220791U (en) * | 2017-01-23 | 2018-04-13 | 储传敏 | A kind of percutaneous nephrolithy of end bendable |
-
2018
- 2018-06-25 CN CN201810666493.0A patent/CN108938137B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1623516A (en) * | 2003-12-06 | 2005-06-08 | 李黎波 | Light power therapy special puncture needle |
| CN201135707Y (en) * | 2007-01-15 | 2008-10-22 | 郑成福 | A device for treating prostatic disease and females urethra syndrome |
| CN101002698A (en) * | 2007-01-18 | 2007-07-25 | 郑成福 | Apparatus for treating prostate diseases, and its making method |
| CN201324233Y (en) * | 2008-09-12 | 2009-10-14 | 夏术阶 | Adjustable fiber urethrocystoscope |
| CN205759152U (en) * | 2016-04-20 | 2016-12-07 | 深圳市第二人民医院 | A kind of aciculiform optical dynamic therapy device |
| CN207220791U (en) * | 2017-01-23 | 2018-04-13 | 储传敏 | A kind of percutaneous nephrolithy of end bendable |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528349A (en) * | 2019-01-22 | 2019-03-29 | 广西医科大学第附属医院 | A kind of novel meiofauna uterine perfusion device |
| CN109528349B (en) * | 2019-01-22 | 2024-02-20 | 广西医科大学第一附属医院 | Novel small animal uterus perfusion device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108938137B (en) | 2021-02-23 |
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