CN109528349A - A kind of novel meiofauna uterine perfusion device - Google Patents

A kind of novel meiofauna uterine perfusion device Download PDF

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Publication number
CN109528349A
CN109528349A CN201910057553.3A CN201910057553A CN109528349A CN 109528349 A CN109528349 A CN 109528349A CN 201910057553 A CN201910057553 A CN 201910057553A CN 109528349 A CN109528349 A CN 109528349A
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CN
China
Prior art keywords
needle
conduit
meiofauna
novel
extension tube
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
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CN201910057553.3A
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Chinese (zh)
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CN109528349B (en
Inventor
杨华
杨一华
黄秋艳
覃爱平
刘博�
谢易冉
莫琳玲
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First Affiliated Hospital of Guangxi Medical University
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First Affiliated Hospital of Guangxi Medical University
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Priority to CN201910057553.3A priority Critical patent/CN109528349B/en
Publication of CN109528349A publication Critical patent/CN109528349A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04Macromolecular materials
    • A61L29/041Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A61L29/042Rubbers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04Macromolecular materials
    • A61L29/06Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The invention discloses a kind of novel meiofauna uterine perfusion devices, belong to the field of medical instrument technology.The novel meiofauna uterine perfusion device includes conduit, three-way connection, extension tube, batching pig and steel needle component, one end of the conduit and extension tube is connect with the two of them interface of the three-way connection respectively, the batching pig is set in another interface of the three-way connection, fixed device and tongs are equipped at intervals in the extension tube, one end far from the three-way connection of the fixed device and the movable connection of the extension tube, the extension tube is additionally provided with a syringe adapter;The needle tip of steel needle passes through the batching pig and is inserted into the conduit in the steel needle component, and the steel needle is equipped with protrusion.The present invention is able to guide conduit and reaches uterine cavity accurate location, is preferably bonded that reflux rate is few with uterus cavity tissue, and the local damage in uterus is small.

Description

A kind of novel meiofauna uterine perfusion device
Technical field
The present invention relates to the field of medical instrument technology, more particularly, to a kind of novel meiofauna uterine perfusion device.
Background technique
According to experiment needs, especially in the research of field of reproduction, need to simulate on animal clinically using drug into The method of row uterine cavity perfusion or the model that building disease is perfused by uterine cavity, and then carry out relative mechanism and grind Study carefully.As currently used experimental animal, rodent uterine cavity is narrow, and cervix opening diameter is small, double for single vagina uterus duplex Uterine neck there is no the effectively easy method and device for simulating clinically intrauterine perfusion at present in the research of above-mentioned basal animal, related Experiment need to prick uterus locally injecting after the cornua uteri of distal end using fu jie is opened, and similar approach fails to simulate clinically uterine perfusion completely Method, local injection of uterus damage endometrium and muscle layer, postoperative uterus local lump, infection and abdominal cavity adhesion rate compared with Height even results in mortality of animals raising, and the disturbing factor of scientific research increases, and finally reduces experimental reliability.
In presently relevant research frequently with through abdomen puncture mesometrium toward uterine cavity injection of medicine, this method have it is following not Foot: 1. are formed directly into mesometrium injection uterine cavity, fail the method for reproduction of reality clinically uterus intrauterine perfusion, use this method It carries out modeling and therapeutic effect is unreliable.2. injecting from uterine cavity, medical fluid can flow to vagina, and ligation distal end uterus is needed before injection Chamber increases the damage of uterus and peripheral vascular tissue, postoperative to may occur in which local hemorrhage, oedema, infection and Asherman's syndrom, intervenes Experiment effect.3. injecting mesometrium through abdomen, medical fluid can be oozed out from injection point, increase the loss of drug, while medical fluid extravasation increases Add the probability of adhesion and the pollution of abdominal viscera.Therefore, a kind of device for being effectively used for uterine perfusion need to be developed.
Summary of the invention
Regarding the issue above, the present invention provides a kind of novel meiofauna uterine perfusion device, the device In conduit can be preferably bonded with uterus cavity tissue, and local damage is small;Meanwhile anti-stab Hose Jacket can be adjusted rapidly setting Guan Shineng Steel needle reaches accurate location without damaging endometrium and muscle layer, and sustainable protection during setting pipe in whole conduit;On steel needle Protrusion identified as the withdraw of the needle, after can be used for instructing to set pipe success, the withdraw of the needle is accurately positioned to inject perfusion solution.
To achieve the goals above, The technical solution adopted by the invention is as follows:
A kind of novel meiofauna uterine perfusion device, including conduit, three-way connection, extension tube, batching pig and steel needle One end of component, the conduit and extension tube is connect with the two of them interface of the three-way connection respectively, and the batching pig is set In in another interface of the three-way connection, being equipped at intervals with fixed device and tongs, the fixed device in the extension tube A syringe adapter is additionally provided with one end far from the three-way connection of the movable connection of the extension tube, the extension tube; The needle tip of steel needle passes through the batching pig and is inserted into the conduit in the steel needle component, and the steel needle is equipped with protrusion.
Further, the steel needle component include steel needle, end set on the steel needle far from the needle tip first Needle stand and the second needle stand, first needle stand are connect with the steel needle, and second needle stand and first needle stand are far from described One end of steel needle connects, and is linked with the anti-stab Hose Jacket with opening, the anti-stab hose by a filament on first needle stand Set is elastic pipe sleeve, and the filament is elastica, and second needle stand is equipped with and holds needle handle.
Further, the three-way connection is transparent adapter of plastic.
Further, the fixed device includes the noose being connected and an equilateral triangle pedestal, the noose and institute State the movable connection of extension tube.
Further, the bottom of the equilateral triangle pedestal is equipped with and can be used for for the extension tube being fixed on station It pastes.
Further, the needle tip is triangle, and the needle handle of holding is fish dorsal fin type.
Further, the diameter of first needle stand is less than the diameter of second needle stand;The diameter of first needle stand For 4-5 mm, the diameter of second needle stand is 6-7mm;The diameter of the anti-stab Hose Jacket is 6-7mm, Bian Houwei 3mm.
Further, the length of the conduit is 3.5-4cm, and the diameter of the conduit is 1-1.5mm, the extension tube Length is 10cm.
Further, one end far from the three-way connection of the conduit is arc port.
Further, the conduit is mainly made of the component of following parts by weight: 12-18 parts of natural rubber, polyester fiber 10-15 parts, 5-10 parts of polyurethane elastomer, 3-7 parts of epoxy resin and 2-5 parts of dibutyl phthalate.
Due to the adoption of the above technical scheme, the invention has the following advantages:
1. catheter tip seat with inward arc of the invention, the anatomical features that animal cervical orifice can be overcome narrow make conduit It is inserted into and is easier to realize, conduit is small to local damage when being inserted into;Conduit caliber meets with animal caliber height, is not necessarily to after conduit insertion It is fixed, while ensuring medical fluid without backflowing.Catheter length 3.5-4cm can just meet from vagina and be inserted into internal cervical orifice Required distance, meanwhile, the intrauterine mechanical disturbance of antithetical phrase can be reduced.In addition, conduit material is soft and tough, can with uterus cavity tissue compared with Good fitting, and local damage is small.
2. anti-stab Hose Jacket of the invention reaches accurate location in conduit for fixing steel needle, makes to set Guan Shineng and preferably guide Conduit, while not damaging endometrium and muscle layer again;Protrusion on the steel needle is set for identifying as the withdraw of the needle for instructing After pipe success, the withdraw of the needle is accurately positioned to inject perfusion solution;The syringe interface can be external simultaneously with various model syringes Injection;The tongs can meet perfusion tensile requirements;Mobilizable fixed device can be adhered in station in the extension tube On, it plays fixed and branch and is referred to as use, anti-locking apparatus falls off.
3. the present invention is small-sized convenient, at low cost, routine experiment disinfection can be met, improve the efficiency of experiment and easy to operate, Perfusion finishes, and medical fluid can be recycled through external syringe, if medical fluid is needed to keep residual, quickly extracts conduit, because cervical orifice is narrow, Medical fluid can remain and continue to act in short time.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of novel meiofauna uterine perfusion device of the embodiment of the present invention;
Fig. 2 is the structural representation of steel needle component in a kind of novel meiofauna uterine perfusion device of the embodiment of the present invention Figure.
In attached drawing, 1- conduit, 2- three-way connection, 3- extension tube, 4- batching pig, 5- steel needle, the fixed device of 6-, 61- noose, 62- equilateral triangle pedestal, 7- tongs, 8- syringe adapter, 9- protrusion, the first needle stand of 10-, the second needle stand of 11-, 12- are anti-stab Hose Jacket, 13- filament, 14- hold needle handle.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that the described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.Based on this Embodiment in invention, every other reality obtained by those of ordinary skill in the art without making creative efforts Example is applied, shall fall within the protection scope of the present invention.
It should be noted that it can be directly on another component when component is referred to as " being fixed on " another component Or there may also be components placed in the middle.When a component is considered as " connection " another component, it, which can be, is directly connected to To another component or it may be simultaneously present component placed in the middle.When a component is considered as " being set to " another component, it It can be and be set up directly on another component or may be simultaneously present component placed in the middle.Term as used herein is " vertical ", " horizontal ", "left", "right" and similar statement for illustrative purposes only.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool The purpose of the embodiment of body, it is not intended that the limitation present invention.Term " and or " used herein includes one or more related Listed item any and all combinations.
Embodiment
Such as Fig. 1 and Fig. 2, a kind of novel meiofauna uterine perfusion device, including conduit 1, three-way connection 2, extension tube 3, one end of batching pig 4 and steel needle component, the conduit 1 and extension tube 3 two of them interface with the three-way connection 2 respectively Connection, the batching pig 4 are set in another interface of the three-way connection 2.The separate three-way connection 2 of the conduit 1 One end is arc port, so that the anatomical features that the present invention can overcome animal cervical orifice narrow, makes the insertion of conduit 1 be easier to realize, And it is small to local damage when the insertion of conduit 1.The three-way connection 2 is transparent adapter of plastic, in order to observe.The extension Fixed device 6 and tongs 7, the fixed device 6 and the movable connection of the extension tube 3, the extension are equipped at intervals on pipe 3 One end far from the three-way connection 2 of pipe 3 is additionally provided with a syringe adapter 8.The needle tip of steel needle 5 is worn in the steel needle component The batching pig 4 is crossed to be inserted into the conduit 1.
Further, the steel needle component includes steel needle 5, set on the of the end of the steel needle 5 far from the needle tip One needle stand 10 and the second needle stand 11, the needle point protrusion triangular in shape of the steel needle 5, the steel needle 5 are equipped with protrusion 9, and protrusion 9 is made The withdraw of the needle is accurately positioned to inject perfusion solution for instructing after setting pipe success for identification point.First needle stand 10 with it is described Steel needle 5 connects, and second needle stand 11 is connect with first needle stand 10 far from one end of the steel needle 5, first needle stand It by the diameter that a filament 13 is linked with band opening is the anti-stab Hose Jacket 12 of 6-7mm on 10, it is described anti-stab soft in the present embodiment Pipe sleeve 12 is elastic pipe sleeve, and the diameter of anti-stab Hose Jacket 12 is 6mm, wherein between the internal diameter and outer diameter of anti-stab Hose Jacket 12 Distance is 1mm, and the side thickness of anti-stab Hose Jacket 12 is 3mm (distance between the opposite end surface of i.e. anti-stab Hose Jacket 12), described thin Line 13 is elastica, and second needle stand 11 is equipped with and holds needle handle 14.The diameter of first needle stand 10 is less than second needle The diameter of seat 11;The diameter of first needle stand 10 is 4-5mm, and the diameter of second needle stand 11 is 6-7mm.The present embodiment In, the diameter of first needle stand 10 is 4mm, and the diameter of second needle stand 11 is 6mm.
When anti-stab Hose Jacket 12 to be placed on the first needle stand 10, anti-stab Hose Jacket 12 can be used for fixing steel needle 5, make to operate Person sets Guan Qianneng and steel needle 5 is fallen back on accurate location in conduit 1 rapidly, meanwhile, and can prevent in operation steel needle 5 from accidentally wearing damage Endometrium and muscle layer.When removing anti-stab Hose Jacket 12 from the first needle stand 10, the first needle stand 10 can be connected with three completely It is first-class to coincide, it when the needle point of steel needle 5 externally protrudes out in conduit, can be used when remaining needle, the arteriovenous for animal is taken a blood sample, and an object is reached Multi-purpose approach.
Further, the fixed device 6 includes the noose 61 and an equilateral triangle pedestal 62 being connected, the noose 61 with the movable connection of the extension tube 3, the bottom of the equilateral triangle pedestal 62, which is equipped with, can be used for consolidating the extension tube 3 Due to the stickup on station.
Further, the needle handle 14 of holding is fish dorsal fin type, and fish dorsal fin type holds needle handle 14 not merely with gripping, and there is no harm in Hinder the use of anti-stab Hose Jacket 12, while being conducive to set pipe (i.e. the merging of conduit 1).
Further, the length of the conduit 1 is 3.5-4cm, and the diameter of the conduit 1 is 1-1.5mm, can just be met The required distance of internal cervical orifice and the size requirements of orificium internUm isthmi are inserted into from vagina, meanwhile, it is intrauterine antithetical phrase can be reduced Mechanical disturbance.In the present embodiment, the length of the conduit 1 is preferably 3.5cm, and the diameter of the conduit 1 is preferably 1mm.It is described The length of extension tube 3 is 10cm, in order to installation, movement and the installation of tongs 7 etc. of fixed device 6.
Further, the conduit 1 is mainly made of the component of following parts by weight: 12-18 parts of natural rubber, polyester fiber 10-15 parts, 5-10 parts of polyurethane elastomer, 3-7 parts of epoxy resin and 2-5 parts of dibutyl phthalate.Natural rubber has Good flexibility and elasticity, polyester fiber can act on reinforcing material, and the addition of polyurethane elastomer further enhances rubber Elasticity and intensity, epoxy resin plays good bonding effect, and a certain amount of dibutyl phthalate can reinforced epoxy tree The viscosity of rouge, therefore, by using these materials make so that not only pliability is higher for conduit 1, elasticity is good, and toughness also compared with By force, it be bonded it can with uterus cavity tissue preferably, and small to the local damage in uterus.In the present embodiment, the conduit 1 mainly by The component of following parts by weight is made: 16 parts of natural rubber, 12 parts of polyester fiber, 8 parts of polyurethane elastomer, 5 parts of epoxy resin and 3 parts of dibutyl phthalate.The production method of conduit 1 is identical as general tubing production, no longer repeats herein.Other are implemented In example, the making material of anti-stab Hose Jacket 12 can also be identical as the making material of conduit 1.
The application method of apparatus of the present invention are as follows: will be drawn outside steel needle, anti-stab pipe sleeve is covered on small needle stand, adjustment distance is closed It is suitable, check that needle point has been retracted into 1-1.5mm or so in conduit;Steel needle is placed in vagina, while softly exploring uterine neck with catheter tip Collar extension and entrance of taking advantage of a situation maintain catheter tip at the joint of two palaces angle, gently extract the high spot (mark on steel needle to the needle body At knowledge), adjustment extends pipe fixing device and fixation, prevents apparatus of the present invention from falling off, syringe interface separately is accessed outside with syringe, Medical fluid is injected, that is, realizes the perfusion in uterus.In this course, it can need to adjust (clamp) tongs according to experiment and keep son Palace fills tension.
Above description is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair Bright patent claim, it is all the present invention suggested by technical spirit under completed same changes or modifications change, should all belong to In the covered the scope of the patents of the present invention.

Claims (10)

1. a kind of novel meiofauna uterine perfusion device, it is characterised in that: including conduit, three-way connection, extension tube, isolation One end of plug and steel needle component, the conduit and extension tube is connect with the two of them interface of the three-way connection respectively, described Batching pig is set in another interface of the three-way connection, and fixed device and tongs are equipped at intervals in the extension tube, described One end far from the three-way connection of fixed device and the movable connection of the extension tube, the extension tube is additionally provided with an injection Device connector;The needle tip of steel needle passes through the batching pig and is inserted into the conduit in the steel needle component, and the steel needle is equipped with Protrusion.
2. novel meiofauna uterine perfusion device as described in claim 1, it is characterised in that: the steel needle component includes Steel needle, the first needle stand and the second needle stand set on the end far from the needle tip of the steel needle, first needle stand and institute Steel needle connection is stated, second needle stand is connect with first needle stand far from one end of the steel needle, is led on first needle stand It crosses a filament and is linked with the anti-stab Hose Jacket with opening, the anti-stab Hose Jacket is elastic pipe sleeve, and the filament is elastica, institute State the second needle stand be equipped with hold needle handle.
3. novel meiofauna uterine perfusion device as described in claim 1, it is characterised in that: the three-way connection is Bright adapter of plastic.
4. novel meiofauna uterine perfusion device as described in claim 1, it is characterised in that: the fixed device includes The noose and an equilateral triangle pedestal being connected, the noose and the movable connection of the extension tube.
5. novel meiofauna uterine perfusion device as claimed in claim 4, it is characterised in that: the equilateral triangle pedestal Bottom be equipped with the stickup that can be used for being fixed on the extension tube on station.
6. novel meiofauna uterine perfusion device as claimed in claim 2, it is characterised in that: the needle tip of the steel needle For triangle, the needle handle of holding is fish dorsal fin type.
7. novel meiofauna uterine perfusion device as claimed in claim 2, it is characterised in that: first needle stand it is straight Diameter is less than the diameter of second needle stand;The diameter of first needle stand is 4-5mm, and the diameter of second needle stand is 6-7mm; The diameter of the anti-stab Hose Jacket is 6-7mm, Bian Houwei 3mm.
8. novel meiofauna uterine perfusion device as described in claim 1, it is characterised in that: the length of the conduit is 3.5-4cm, the diameter of the conduit are 1-1.5mm, and the length of the extension tube is 10cm.
9. novel meiofauna uterine perfusion device as described in claim 1, it is characterised in that: the separate institute of the conduit The one end for stating three-way connection is arc port.
10. novel meiofauna uterine perfusion device as described in claim 1, it is characterised in that: the conduit mainly by The component of following parts by weight is made: 12-18 parts of natural rubber, 10-15 parts of polyester fiber, 5-10 parts of polyurethane elastomer, epoxy 3-7 parts and dibutyl phthalate 2-5 parts of resin.
CN201910057553.3A 2019-01-22 2019-01-22 Novel small animal uterus perfusion device Active CN109528349B (en)

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CN109528349B CN109528349B (en) 2024-02-20

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Cited By (1)

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CN115191363A (en) * 2022-07-12 2022-10-18 广西医科大学第一附属医院 Joint movement testing system and testing method for experimental animals

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Publication number Priority date Publication date Assignee Title
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