CN107753145A - Simple machine for zoopery perfusion - Google Patents
Simple machine for zoopery perfusion Download PDFInfo
- Publication number
- CN107753145A CN107753145A CN201711119361.8A CN201711119361A CN107753145A CN 107753145 A CN107753145 A CN 107753145A CN 201711119361 A CN201711119361 A CN 201711119361A CN 107753145 A CN107753145 A CN 107753145A
- Authority
- CN
- China
- Prior art keywords
- needle
- syringe
- straight tube
- perfusion
- zoopery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000010412 perfusion Effects 0.000 title claims abstract description 32
- 210000003128 head Anatomy 0.000 claims description 16
- 230000000977 initiatory effect Effects 0.000 claims description 6
- 238000001467 acupuncture Methods 0.000 claims description 5
- 210000004761 scalp Anatomy 0.000 claims description 5
- 239000007788 liquid Substances 0.000 abstract description 10
- 210000005003 heart tissue Anatomy 0.000 abstract description 4
- 230000002572 peristaltic effect Effects 0.000 abstract description 4
- 230000001105 regulatory effect Effects 0.000 abstract description 4
- 239000003182 parenteral nutrition solution Substances 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 2
- 241001465754 Metazoa Species 0.000 description 6
- 210000005240 left ventricle Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 238000005452 bending Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000004088 pulmonary circulation Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a kind of simple machine for zoopery perfusion, it is related to biological experiment equipment technical field.The equipment includes syringe needle, straight tube and syringe；Syringe needle includes needle tubing, circular baffle plate, needle hub；The head of needle tubing is tack needle point, and the afterbody of needle tubing is arranged with needle hub；Circular baffle plate is movably set on needle tubing outer wall；Straight tube includes straight tube tube head, straight tube body and straight tube pipe tail successively；Straight tube tube head has the structure being adapted with needle hub, and closely can be entrenched in needle hub；Straight tube pipe tail is to close connection syringe.For example and without limitation, scheme provided by the invention, its advantage are：Depth of needle can be regulated and controled by the setting of circular baffle plate, reduced using tack pin to damage to cardiac tissue；Coming off for syringe needle effectively prevent using straight tube conveying perfusion liquid；Peristaltic pump is substituted using syringe, and the speed of parenteral solution can be adjusted according to scale；It is easy to assembly, it is easy to use.
Description
Technical field
The invention belongs to biological experiment equipment technical field, more particularly to a set of simply setting for zoopery perfusion
It is standby.
Background technology
Perfusion fixation is blood circulation in a kind of removing animal body, tissue is preserved the knot close to life state as far as possible
Structure, fixed intracellular various composition, after death itself enzyme decomposition is avoided self-dissolving occur, or external microbe intrusion breeding causes carefully
The ultra microstructure of born of the same parents is widely used in the scientific research of the nervous system disease by a kind of infrastest method destroyed.Generally,
It is that first will open chest after Animal Anesthesia that the perfusion of experimental animal, which is fixed, exposes heart, catheter needle then is inserted into left ventricle, simultaneously
Right auricle of heart is broken, the physiological saline for first filling close with the weight of animals volume rinses the blood in body circulation, typically with from the right side
The limpid liquid of auricle outflow is standard, 4% paraformaldehyde of rear re perfusion volume close with the weight of animals, whole perfusion fixation
Process just complete.
At present, the conventional catheter needle in laboratory is the disposable vein blood taking needle clinically used, the vein blood taking needle
Needle point Duan Weiyue 3mm inclined-plane, though so that inserting needle blood vessel is easier, because the left ventricle capacity of mouse is small, it is easily pricked deeply simultaneously
Left ventricle is penetrated into right ventricle so as to causing pulmonary circulation to irrigate, the swelling that lung is filled is shown as and turns white, and body circulation then without
Effectively perfusion.If cross shallow inserting needle, it is likely that cause the syringe needle inserting needle on inclined-plane incomplete, cause perfusion liquid not enter ventricle, portion entirely
Exceptionally flow so as to cause perfusion incomplete.Secondly, the bending shape of vein blood taking needle flexible pipe so that syringe needle after left ventricle is inserted again
Easily spin, so as to cause needle position to change or be come off from heart.Inserting needle again is difficult often to find at original inserting needle,
Many places inserting needle mouth caused by so, part perfusion liquid will flow out directly at other pin mouths when perfusion.
The content of the invention
It is an object of the present invention to overcome the deficiencies in the prior art, solves the defects of clinically existing catheter needle, there is provided one
Kind is used for the simple machine of zoopery perfusion, the controllable depth of needle of the equipment, effectively holds the inserting needle degree of accuracy, and can reduce
To damage to cardiac tissue, and simple operation.
In order to realize above-mentioned target, the invention provides following technical scheme：
A kind of simple machine for zoopery perfusion, it is characterised in that：Including syringe needle, straight tube and syringe；It is described
Syringe needle includes needle tubing, circular baffle plate, needle hub；The head of the needle tubing is tack needle point, and the afterbody of needle tubing is arranged with syringe needle
Interface；The circular baffle plate is movably set on needle tubing outer wall；The straight tube successively include straight tube tube head, straight tube body and
Straight tube pipe tail；The straight tube tube head has the structure being adapted with needle hub, and closely can be entrenched in needle hub；Institute
State head of the straight tube pipe tail to close connection syringe.
Preferably, it is provided with screw thread on the outer wall of the needle tubing；The spiral shell with needle tubing outer wall is offered in the circular baffle plate
The screwed hole that line matches；The circular baffle plate is movably set in by the screwed hole on the screw thread of needle tubing outer wall.
Preferably, the distance of the initiating terminal anomaly scalp acupuncture point of the screw thread is 4mm-5mm.
Further preferably, the distance of the initiating terminal anomaly scalp acupuncture point of the screw thread is 3mm.
Further, the syringe includes syringe interface, injector syringe and piston component；The syringe interface position
Connected in the head of injector syringe, and with injector syringe；And the syringe interface has what is be adapted with straight tube pipe tail
Structure, and can closely be entrenched in straight tube pipe tail；The piston component has the chi adaptable with the internal diameter of injector syringe
Very little, it loads in injector syringe from the afterbody of injector syringe, and can be moved in injector syringe.
Preferably, the injector syringe is transparent, and is provided with scale on its outer wall.
The above technical scheme that the present invention uses, compared with prior art, for example and without limitation, have beneficial below
Effect：(1) depth of needle can be regulated and controled by the setting of circular baffle plate, is reduced using tack pin to damage to cardiac tissue；
(2) coming off for syringe needle effectively prevent using straight tube conveying perfusion liquid；(3) peristaltic pump is substituted using syringe, and can root
The speed of parenteral solution is adjusted according to scale；(4) it is easy to assembly, it is easy to use.
Brief description of the drawings
Fig. 1 is the schematic diagram of the simple machine of the present invention for zoopery perfusion；
Fig. 2 is the schematic diagram of syringe needle of the present invention；
Fig. 3 is the schematic diagram of straight tube of the present invention；
Fig. 4 is the schematic diagram of syringe of the present invention.
Description of reference numerals
1 syringe needle, 11 needle tubings, 12 circular baffle plates, 13 needle hubs, 14 screw threads；
2 straight tubes, straight tube tube head 21, straight tube body 22, straight tube pipe tail 23；
3 syringes, syringe interface 31, injector syringe 32, piston component 33.
Embodiment
Below in conjunction with specific embodiment and its accompanying drawing to the simple machine that is irrigated provided by the present invention for zoopery
Technical scheme be described further.With reference to following explanation, advantages and features of the invention will be apparent from.
It should be noted that embodiments of the invention have preferable implementation, it is not to any type of limit of the present invention
It is fixed.The combination of technical characteristic or technical characteristic described in the embodiment of the present invention is not construed as isolated, and they can
Reach superior technique effect to be mutually combined.The scope of the preferred embodiment for the present invention can also include other reality
It is existing, and this should be understood by person of ordinary skill in the field of the embodiment of the present invention.
It may be not discussed in detail for technology, method and apparatus known to person of ordinary skill in the relevant, but suitable
In the case of, the technology, method and apparatus should be considered as authorizing part for specification.Institute that is shown here and discussing
Have in example, any occurrence should be construed as merely exemplary, not as restriction.Therefore, exemplary embodiment
Other examples can have different values.
The accompanying drawing of the present invention uses using very simplified form and non-accurately ratio, only to convenient, apparent
Ground aids in illustrating the purpose of the embodiment of the present invention, is not to limit the enforceable qualifications of the present invention.The modification of any structure,
The change of proportionate relationship or the adjustment of size, in the case where not influenceing the effect of the invention that can be generated and the purpose that can reach,
It should fall in the range of disclosed technology contents can be covered.And the identical label appeared in each accompanying drawing of the present invention
Identical feature or part are represented, can be applied in different embodiments.
The present invention provides a kind of simple machine for zoopery perfusion.
As shown in figure 1, the simple machine for being used for zoopery perfusion includes syringe needle 1, straight tube 2 and syringe 3.
Further, as shown in Fig. 2 syringe needle 1 includes needle tubing 11, circular baffle plate 12, needle hub 13.Wherein, needle tubing 11
Head is tack needle point, and screw thread 14 is provided with the outer wall of needle tubing 11, and the afterbody of needle tubing 11 is arranged with needle hub 13；Circle gear
Offer the screwed hole to match with the screw thread 14 of the outer wall of needle tubing 11 in plate 12, circular baffle plate 12 by the screwed hole movably
It is set on the screw thread 14 of the outer wall of needle tubing 11, by adjusting position of the circular veneer 12 on screw thread 14 inserting needle can be controlled deep
Spend (length of needle tubing 11 before circular baffle plate 12 is inserting needle degree).
In a preferred embodiment, the initiating terminal of screw thread 14 is 4mm-5mm apart from tack needle point, more preferably
3mm.Because 3mm is depth of needle when being irrigated relative to mouse, the heart of rat or other animals is larger, corresponding
Depth of needle it is also longer, therefore, the initiating terminal of screw thread 14 can be 3mm apart from the minimum range of tack needle point.
In the present invention, the needle tubing 11 of syringe needle 1 employs tack syringe needle；For the hollow organs such as heart, tack pin
Inserting needle resistance is also little, and the damage to tissue is also small, and effective depth of needle of tack pin is longer than bevel needle, is less susceptible to pierce through
Left ventricle., can be according to the different adjustment depth of needle of animal varieties, such as mouse inserting needle left ventricle 3- in actual mechanical process
4mm, then can be with back rotation circular baffle plate 12 if rat, and adjustment depth of needle is 5-6mm.
Further, as shown in figure 3, straight tube 2 includes straight tube tube head 21, straight tube body 22 and straight tube pipe tail 23 successively.Wherein,
Straight tube tube head 21 has the structure adaptable with the needle hub 13 of syringe needle 1, and can closely be entrenched in needle hub 13, with
Prevent leakage；Straight tube body 22 is conveying perfusion liquid；Straight tube pipe tail 23 is used to connect syringe 3.
For example and without limitation, the structure of straight tube tube head 21 and needle hub 13 can use the note of clinically injection
The syringe of emitter and the construction of needle cap；And both are closely fitted together to no leakage.
In the present invention, the effect of straight tube 2 is to convey perfusion liquid, and the perfusion liquid in syringe 3 passes through again after flowing through straight tube 2
Syringe needle 1 enters heart.Because perfusion is a process slowly infused, it can avoid bending as flexible pipe using straight tube 2, make
Come off into injection needle 1.Meanwhile after syringe needle 1 connects straight tube 2, straight tube 2 slightly can apply a power forward to circular baffle plate 12, make
It is more firm to obtain syringe needle 1；Namely syringe 3 somewhat toward sinciput once, thus give 1 one, syringe needle equivalent to by straight tube 2
Power forward, can be more firm so as to promote circular baffle plate 12 to be bonded heart.
Further, as shown in figure 4, syringe 3 includes syringe interface 31, injector syringe 32 and piston component 33.Its
In, syringe interface 31 is located at the head of injector syringe 32, and is connected with injector syringe 32；Meanwhile adaptable structure,
And can closely be entrenched in straight tube pipe tail 23, to prevent leak-stopping liquid；Piston component 33 has the internal diameter phase with injector syringe 32
The size of adaptation, it loads in injector syringe 32 from the afterbody of injector syringe 32, and can be moved in injector syringe 32；
Injector syringe 32 is provided with scale to be transparent on its outer wall, can be regulating and controlling the speed of perfusion.
For example and without limitation, syringe interface 31 can be using clinically injection with the structure of straight tube pipe tail 23
The needle cap of syringe and the construction of syringe；And both are closely fitted together to no leakage.
The present invention is relative, and some do not have the experimental place of peristaltic pump, and the utilization of syringe 3 greatly solves shortage and wriggled
The problem of pump.
The above technical scheme that the present invention uses, compared with prior art, for example and without limitation, have beneficial below
Effect：(1) depth of needle can be regulated and controled by the setting of circular baffle plate, is reduced using tack pin to damage to cardiac tissue；
(2) coming off for syringe needle effectively prevent using straight tube conveying perfusion liquid；(3) peristaltic pump is substituted using syringe, and can root
The speed of parenteral solution is adjusted according to scale；(4) it is easy to assembly, it is easy to use.
Foregoing description is only the description to present pre-ferred embodiments, is not any restriction to the scope of the invention.Appoint
Any change or modification what those skilled in the art makes according to the technology contents of the disclosure above should regard
For equivalent effective embodiment, the scope that technical solution of the present invention is protected is belonged to.
Claims (6)
- A kind of 1. simple machine for zoopery perfusion, it is characterised in that：Including syringe needle (1), straight tube (2) and syringe (3)；The syringe needle (1) includes needle tubing (11), circular baffle plate (12), needle hub (13)；The head of the needle tubing (11) is flat Scalp acupuncture point, the afterbody of needle tubing (11) are arranged with needle hub (13)；The circular baffle plate (12) is movably set in needle tubing (11) on outer wall；The straight tube (2) includes straight tube tube head (21), straight tube body (22) and straight tube pipe tail (23) successively；The straight tube tube head (21) there is the structure being adapted with needle hub (13), and can closely be entrenched in needle hub (13)；The straight tube pipe Tail (23) is to the close head for connecting syringe (3).
- 2. the simple machine according to claim 1 for zoopery perfusion, it is characterised in that：The needle tubing (11) Screw thread (14) is provided with outer wall；Offer what is matched with the screw thread (14) of needle tubing (11) outer wall in the circular baffle plate (12) Screwed hole；The circular baffle plate (12) is movably set in by the screwed hole on the screw thread (14) of needle tubing (11) outer wall.
- 3. the simple machine according to claim 1 for zoopery perfusion, it is characterised in that：The screw thread (14) The distance of initiating terminal anomaly scalp acupuncture point is 4mm-5mm.
- 4. the simple machine according to claim 3 for zoopery perfusion, it is characterised in that：The screw thread (14) The distance of initiating terminal anomaly scalp acupuncture point is 3mm.
- 5. the simple machine according to claim 1 for zoopery perfusion, it is characterised in that：The syringe (3) Including syringe interface (31), injector syringe (32) and piston component (33)；The syringe interface (31) is located at the head of injector syringe (32), and is connected with injector syringe (32)；It is and described Syringe interface (31) has the structure being adapted with straight tube pipe tail (23), and can closely be entrenched in straight tube pipe tail (23)； The piston component (33) has the size adaptable with the internal diameter of injector syringe (32), its tail from injector syringe (32) Portion loads in injector syringe (32), and can be moved in injector syringe (32).
- 6. the simple machine according to claim 5 for zoopery perfusion, it is characterised in that：The injector syringe (32) to be transparent, and scale is provided with its outer wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711119361.8A CN107753145A (en) | 2017-11-14 | 2017-11-14 | Simple machine for zoopery perfusion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711119361.8A CN107753145A (en) | 2017-11-14 | 2017-11-14 | Simple machine for zoopery perfusion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107753145A true CN107753145A (en) | 2018-03-06 |
Family
ID=61272847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711119361.8A Pending CN107753145A (en) | 2017-11-14 | 2017-11-14 | Simple machine for zoopery perfusion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107753145A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528349A (en) * | 2019-01-22 | 2019-03-29 | 广西医科大学第附属医院 | A kind of novel meiofauna uterine perfusion device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934105A (en) * | 2009-06-30 | 2011-01-05 | 王立祥 | Disposable intra-bone marrow injection device |
| CN105561421A (en) * | 2015-12-22 | 2016-05-11 | 河南诺沃组织工程有限公司 | Heart and brain perfusion injection needle for rats |
| CN106377338A (en) * | 2016-10-25 | 2017-02-08 | 苏州大学 | Syringe needle head and use method of syringe |
| CN206007400U (en) * | 2016-07-07 | 2017-03-15 | 齐齐哈尔医学院 | Experiment mice heart irrigator |
| CN209360983U (en) * | 2017-11-14 | 2019-09-10 | 上海市杨浦区中心医院 | Simple machine for zoopery perfusion |
-
2017
- 2017-11-14 CN CN201711119361.8A patent/CN107753145A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934105A (en) * | 2009-06-30 | 2011-01-05 | 王立祥 | Disposable intra-bone marrow injection device |
| CN105561421A (en) * | 2015-12-22 | 2016-05-11 | 河南诺沃组织工程有限公司 | Heart and brain perfusion injection needle for rats |
| CN206007400U (en) * | 2016-07-07 | 2017-03-15 | 齐齐哈尔医学院 | Experiment mice heart irrigator |
| CN106377338A (en) * | 2016-10-25 | 2017-02-08 | 苏州大学 | Syringe needle head and use method of syringe |
| CN209360983U (en) * | 2017-11-14 | 2019-09-10 | 上海市杨浦区中心医院 | Simple machine for zoopery perfusion |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528349A (en) * | 2019-01-22 | 2019-03-29 | 广西医科大学第附属医院 | A kind of novel meiofauna uterine perfusion device |
| CN109528349B (en) * | 2019-01-22 | 2024-02-20 | 广西医科大学第一附属医院 | Novel small animal uterus perfusion device |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| WD01 | Invention patent application deemed withdrawn after publication | ||
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Application publication date: 20180306 |